Aspergillus nidulans FGSC A4

Summary

Alias: Emericella nidulans FGSC A4

Top Publications

  1. Koukaki M, Vlanti A, Goudela S, Pantazopoulou A, Gioule H, Tournaviti S, et al. The nucleobase-ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway. J Mol Biol. 2005;350:499-513 pubmed
    ..Our results show that the NAT signature motif defines the function of the UapA purine translocation pathway and strongly suggest that this might occur by determining the interactions of UapA with the imidazole part of purines. ..
  2. Krappmann S, Jung N, Medic B, Busch S, Prade R, Braus G. The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis. Mol Microbiol. 2006;61:76-88 pubmed
  3. Wang J, Hu H, Wang S, Shi J, Chen S, Wei H, et al. The important role of actinin-like protein (AcnA) in cytokinesis and apical dominance of hyphal cells in Aspergillus nidulans. Microbiology. 2009;155:2714-25 pubmed publisher
    ..nidulans. This is the first report, to our knowledge, of the function of an actinin-like protein in filamentous fungi. ..
  4. Edgerton Morgan H, Oakley B. ?-Tubulin plays a key role in inactivating APC/C(Cdh1) at the G(1)-S boundary. J Cell Biol. 2012;198:785-91 pubmed publisher
  5. Seo J, Guan Y, Yu J. FluG-dependent asexual development in Aspergillus nidulans occurs via derepression. Genetics. 2006;172:1535-44 pubmed
    ..Genetic analyses demonstrated that SfgA functions downstream of FluG but upstream of transcriptional activators (FlbD, FlbC, FlbB, and BrlA) necessary for normal conidiation. ..
  6. Vlanti A, Amillis S, Koukaki M, Diallinas G. A novel-type substrate-selectivity filter and ER-exit determinants in the UapA purine transporter. J Mol Biol. 2006;357:808-19 pubmed
    ..The presence of any of the TMS12 tested was necessary for ER-exit while their specific amino acid composition affected the kinetics of chimeras. ..
  7. Zhuang L, Zhang J, Xiang X. Point mutations in the stem region and the fourth AAA domain of cytoplasmic dynein heavy chain partially suppress the phenotype of NUDF/LIS1 loss in Aspergillus nidulans. Genetics. 2007;175:1185-96 pubmed
    ..The fact that a mutation in the end of AAA4 negatively regulates dynein's ATPase activity but partially compensates for NUDF loss indicates the importance of the AAA4 domain in dynein regulation in vivo. ..
  8. Papageorgiou I, Gournas C, Vlanti A, Amillis S, Pantazopoulou A, Diallinas G. Specific interdomain synergy in the UapA transporter determines its unique specificity for uric acid among NAT carriers. J Mol Biol. 2008;382:1121-35 pubmed publisher
    ..We finally show that intramolecular synergy among UapA domains is highly specific and propose that it forms the basis for the evolution of the unique specificity of UapA for uric acid, a property not present in other NAT members. ..
  9. Son S, Osmani S. Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1. Eukaryot Cell. 2009;8:573-85 pubmed publisher
    ..The mitotic defects of the Anfcp1(ts) cdk1F double mutant suggests a previously unrealized function for AnFCP1 in regulating mitotic progression, perhaps counteracting Cdk1-mediated phosphorylation. ..
  10. Nayak T, Edgerton Morgan H, Horio T, Xiong Y, De Souza C, Osmani S, et al. Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase. J Cell Biol. 2010;190:317-30 pubmed publisher
    ..Thus, gamma-tubulin functions to regulate this key mitotic and cell cycle regulatory complex. ..

Detail Information

Publications104 found, 100 shown here

  1. Koukaki M, Vlanti A, Goudela S, Pantazopoulou A, Gioule H, Tournaviti S, et al. The nucleobase-ascorbate transporter (NAT) signature motif in UapA defines the function of the purine translocation pathway. J Mol Biol. 2005;350:499-513 pubmed
    ..Our results show that the NAT signature motif defines the function of the UapA purine translocation pathway and strongly suggest that this might occur by determining the interactions of UapA with the imidazole part of purines. ..
  2. Krappmann S, Jung N, Medic B, Busch S, Prade R, Braus G. The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis. Mol Microbiol. 2006;61:76-88 pubmed
  3. Wang J, Hu H, Wang S, Shi J, Chen S, Wei H, et al. The important role of actinin-like protein (AcnA) in cytokinesis and apical dominance of hyphal cells in Aspergillus nidulans. Microbiology. 2009;155:2714-25 pubmed publisher
    ..nidulans. This is the first report, to our knowledge, of the function of an actinin-like protein in filamentous fungi. ..
  4. Edgerton Morgan H, Oakley B. ?-Tubulin plays a key role in inactivating APC/C(Cdh1) at the G(1)-S boundary. J Cell Biol. 2012;198:785-91 pubmed publisher
  5. Seo J, Guan Y, Yu J. FluG-dependent asexual development in Aspergillus nidulans occurs via derepression. Genetics. 2006;172:1535-44 pubmed
    ..Genetic analyses demonstrated that SfgA functions downstream of FluG but upstream of transcriptional activators (FlbD, FlbC, FlbB, and BrlA) necessary for normal conidiation. ..
  6. Vlanti A, Amillis S, Koukaki M, Diallinas G. A novel-type substrate-selectivity filter and ER-exit determinants in the UapA purine transporter. J Mol Biol. 2006;357:808-19 pubmed
    ..The presence of any of the TMS12 tested was necessary for ER-exit while their specific amino acid composition affected the kinetics of chimeras. ..
  7. Zhuang L, Zhang J, Xiang X. Point mutations in the stem region and the fourth AAA domain of cytoplasmic dynein heavy chain partially suppress the phenotype of NUDF/LIS1 loss in Aspergillus nidulans. Genetics. 2007;175:1185-96 pubmed
    ..The fact that a mutation in the end of AAA4 negatively regulates dynein's ATPase activity but partially compensates for NUDF loss indicates the importance of the AAA4 domain in dynein regulation in vivo. ..
  8. Papageorgiou I, Gournas C, Vlanti A, Amillis S, Pantazopoulou A, Diallinas G. Specific interdomain synergy in the UapA transporter determines its unique specificity for uric acid among NAT carriers. J Mol Biol. 2008;382:1121-35 pubmed publisher
    ..We finally show that intramolecular synergy among UapA domains is highly specific and propose that it forms the basis for the evolution of the unique specificity of UapA for uric acid, a property not present in other NAT members. ..
  9. Son S, Osmani S. Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1. Eukaryot Cell. 2009;8:573-85 pubmed publisher
    ..The mitotic defects of the Anfcp1(ts) cdk1F double mutant suggests a previously unrealized function for AnFCP1 in regulating mitotic progression, perhaps counteracting Cdk1-mediated phosphorylation. ..
  10. Nayak T, Edgerton Morgan H, Horio T, Xiong Y, De Souza C, Osmani S, et al. Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase. J Cell Biol. 2010;190:317-30 pubmed publisher
    ..Thus, gamma-tubulin functions to regulate this key mitotic and cell cycle regulatory complex. ..
  11. Eigentler A, Pocsi I, Marx F. The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans. Arch Microbiol. 2012;194:427-37 pubmed publisher
    ..We therefore conclude that the secreted protein Anisin1 contributes to the optimal development of A. nidulans and we further propose that it has a sensing/signaling function for elevated H(2)O(2) levels. ..
  12. Hernández Rodríguez Y, Hastings S, Momany M. The septin AspB in Aspergillus nidulans forms bars and filaments and plays roles in growth emergence and conidiation. Eukaryot Cell. 2012;11:311-23 pubmed publisher
    ..AspE orthologs are only found in filamentous fungi, suggesting that this class of septins might be required for stability of septin bars and filaments in highly polar cells. ..
  13. Virag A, Harris S. Functional characterization of Aspergillus nidulans homologues of Saccharomyces cerevisiae Spa2 and Bud6. Eukaryot Cell. 2006;5:881-95 pubmed
    ..We propose that the core function of the polarisome in polarized growth is maintained but with different contributions of polarisome components to the process. ..
  14. Calcagno Pizarelli A, Negrete Urtasun S, Denison S, Rudnicka J, Bussink H, Múnera Huertas T, et al. Establishment of the ambient pH signaling complex in Aspergillus nidulans: PalI assists plasma membrane localization of PalH. Eukaryot Cell. 2007;6:2365-75 pubmed
  15. Zhang J, Wang L, Zhuang L, Huo L, Musa S, Li S, et al. Arp11 affects dynein-dynactin interaction and is essential for dynein function in Aspergillus nidulans. Traffic. 2008;9:1073-87 pubmed publisher
    ..We suggest that loss of the pointed-end proteins alters the Arp1 filament in a way that affects the conformation of p150 required for its proper interaction with the dynein motor. ..
  16. Zhang J, Yao X, Fischer L, Abenza J, Peñalva M, Xiang X. The p25 subunit of the dynactin complex is required for dynein-early endosome interaction. J Cell Biol. 2011;193:1245-55 pubmed publisher
    ..These results indicate that p25, in conjunction with the rest of the dynactin complex, is important for dynein-early endosome interaction. ..
  17. Hynes M, Murray S, Khew G, Davis M. Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans. Genetics. 2008;178:1355-69 pubmed publisher
    ..The mitochondrial pathway is not required for growth on valerate or for long-chain fatty acid utilization. ..
  18. Govindaraghavan M, Lad A, Osmani S. The NIMA kinase is required to execute stage-specific mitotic functions after initiation of mitosis. Eukaryot Cell. 2014;13:99-109 pubmed publisher
    ..This study shows that NIMA is required not only for mitotic entry but also sequentially for successful completion of stage-specific mitotic events. ..
  19. Sanchez J, Somoza A, Keller N, Wang C. Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep. 2012;29:351-71 pubmed publisher
    ..Activating these pathways has been met with some success, but many more dormant genes remain to be awakened...
  20. Wartenberg D, Vödisch M, Kniemeyer O, Albrecht Eckardt D, Scherlach K, Winkler R, et al. Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin. J Proteomics. 2012;75:4038-49 pubmed publisher
    ..nidulans and describe a farnesol-inducible dehydrin-like protein that contributes to the high tolerance of resting conidia against oxidative and heat stress...
  21. Kosti V, Papageorgiou I, Diallinas G. Dynamic elements at both cytoplasmically and extracellularly facing sides of the UapA transporter selectively control the accessibility of substrates to their translocation pathway. J Mol Biol. 2010;397:1132-43 pubmed publisher
    ..Our results strongly suggest that distinct domains at both sides of UapA act as selective dynamic gates controlling substrate access to their translocation pathway...
  22. Amillis S, Kosti V, Pantazopoulou A, Mikros E, Diallinas G. Mutational analysis and modeling reveal functionally critical residues in transmembrane segments 1 and 3 of the UapA transporter. J Mol Biol. 2011;411:567-80 pubmed publisher
    ..Our results are in agreement with a topological model of UapA built on the recently published structure of UraA, a bacterial homolog of UapA...
  23. Dilokpimol A, Nakai H, Gotfredsen C, Baumann M, Nakai N, Abou Hachem M, et al. Recombinant production and characterisation of two related GH5 endo-?-1,4-mannanases from Aspergillus nidulans FGSC A4 showing distinctly different transglycosylation capacity. Biochim Biophys Acta. 2011;1814:1720-9 pubmed publisher
    The glycoside hydrolase family 5 (GH5) endo-?-1,4-mannanases ManA and ManC from Aspergillus nidulans FGSC A4 were produced in Pichia pastoris X33 and purified in high yields of 120 and 145mg/L, respectively, from the culture supernatants...
  24. Abenza J, Galindo A, Pinar M, Pantazopoulou A, de los Ríos V, Peñalva M. Endosomal maturation by Rab conversion in Aspergillus nidulans is coupled to dynein-mediated basipetal movement. Mol Biol Cell. 2012;23:1889-901 pubmed publisher
    ..Genetic studies establish that endosomal maturation is essential, whereas homotypic vacuolar fusion is not...
  25. Herv s Aguilar A, Rodr guez J, Tilburn J, Arst H, Pe alva M. Evidence for the direct involvement of the proteasome in the proteolytic processing of the Aspergillus nidulans zinc finger transcription factor PacC. J Biol Chem. 2007;282:34735-47 pubmed publisher
    ..Wild-type PacC(53) becomes multiply phosphorylated upon alkaline pH exposure. Processing-impaired 4K-->R PacC(53) becomes excessively phosphorylated...
  26. Karlsson M, Stenlid J. Comparative evolutionary histories of the fungal chitinase gene family reveal non-random size expansions and contractions due to adaptive natural selection. Evol Bioinform Online. 2008;4:47-60 pubmed
    ..Unicellular growth is correlated with a reduction of chitinase gene copy numbers which emphasizes the requirement of the combined action of several chitinases for filamentous growth...
  27. Wong K, Hynes M, Todd R, Davis M. Deletion and overexpression of the Aspergillus nidulans GATA factor AreB reveals unexpected pleiotropy. Microbiology. 2009;155:3868-80 pubmed publisher
    ..Deletion of either the DNA-binding domain or the leucine zipper domain results in loss of both nitrogen and developmental phenotypes. ..
  28. Liu Z, Gay L, Tuveng T, Agger J, Westereng B, Mathiesen G, et al. Structure and function of a broad-specificity chitin deacetylase from Aspergillus nidulans FGSC A4. Sci Rep. 2017;7:1746 pubmed publisher
    ..We describe the structural and functional characterization of a 237 residue deacetylase (AnCDA) from Aspergillus nidulans FGSC A4. AnCDA acts on chito-oligomers, crystalline chitin, chitosan, and acetylxylan, but not on peptidoglycan...
  29. Kinghorn J, Pateman J. NAD and NADP l-glutamate dehydrogenase activity and ammonium regulation in Aspergillus nidulans. J Gen Microbiol. 1973;78:39-46 pubmed
  30. Pieniazek N, Kowalska I, Stepien P. Deficiency in methionine adenosyltransferase resulting in limited repressibility of methionine biosynthetic enzymes in Aspergillus nidulans. Mol Gen Genet. 1973;126:367-74 pubmed
  31. Scazzocchio C, Darlington A. The induction and repression of the enzymes of purine breakdown in Aspergillus nidulans. Biochim Biophys Acta. 1968;166:557-68 pubmed
  32. Osmani S, Scrutton M. The sub-cellular localisation of pyruvate carboxylase and of some other enzymes in Aspergillus nidulans. Eur J Biochem. 1983;133:551-60 pubmed
    ..A scheme is proposed on the basis of these data to describe the organisation of lipid and amino acid synthesis from glucose in an organism which possesses a cytosolic pyruvate carboxylase. ..
  33. Karachaliou M, Amillis S, Evangelinos M, Kokotos A, Yalelis V, Diallinas G. The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals. Mol Microbiol. 2013;88:301-17 pubmed publisher
  34. De Souza C, Hashmi S, Osmani A, Osmani S. Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans. PLoS ONE. 2014;9:e90911 pubmed publisher
    ..We propose that SepH regulates the septation initiation network (SIN) specifically at SPBs in the basal region of G1 cells and that localized gradients of SIN activity promote asymmetric septation. ..
  35. Govindaraghavan M, McGuire Anglin S, Shen K, Shukla N, De Souza C, Osmani S. Identification of interphase functions for the NIMA kinase involving microtubules and the ESCRT pathway. PLoS Genet. 2014;10:e1004248 pubmed publisher
    ..These insights extend the roles of NIMA both spatially and temporally and indicate that this conserved protein kinase could help integrate cell cycle progression with polarized cell growth...
  36. Yang Y, El Ganiny A, Bray G, Sanders D, Kaminskyj S. Aspergillus nidulans hypB encodes a Sec7-domain protein important for hyphal morphogenesis. Fungal Genet Biol. 2008;45:749-59 pubmed publisher
    ..As has been shown previously for hypA1 mutants, shifting established hypB5 mutant hyphae from a growth temperature of 28-42 degrees C caused septation in and death of tip cells and growth activation of basal cells...
  37. Pinar M, Arst H, Pantazopoulou A, Tagua V, de los Ríos V, Rodríguez Salarichs J, et al. TRAPPII regulates exocytic Golgi exit by mediating nucleotide exchange on the Ypt31 ortholog RabERAB11. Proc Natl Acad Sci U S A. 2015;112:4346-51 pubmed publisher
    ..Thus, TRAPPII marks, and possibly determines, the Golgi-to-post-Golgi transition. ..
  38. Huber E, Scharf D, Hortschansky P, Groll M, Brakhage A. DNA minor groove sensing and widening by the CCAAT-binding complex. Structure. 2012;20:1757-68 pubmed publisher
    ..The herein-described mode of transcription factor binding answers the question of how histone proteins gained sequence specificity for the CCAAT box...
  39. Kinghorn J, Sloan J, Kana n G, Dasilva E, Rouch D, Unkles S. Missense mutations that inactivate the Aspergillus nidulans nrtA gene encoding a high-affinity nitrate transporter. Genetics. 2005;169:1369-77 pubmed publisher
    ..Finally, the study of a strain with a conversion of Trp481 (Tm 12) to a stop codon suggests that all 12 transmembrane domains and/or the C-terminal tail are required for membrane insertion and/or stability of NrtA...
  40. Hernández González M, Peñalva M, Pantazopoulou A. Conditional inactivation of Aspergillus nidulans?sarA(SAR1) uncovers the morphogenetic potential of regulating endoplasmic reticulum (ER) exit. Mol Microbiol. 2015;95:491-508 pubmed publisher
    ..Incubation of sarA6 cells at 37°C led to the formation of apical balloons resembling specialized fungal structures. The formation of these balloons highlights the morphogenetic consequences of impairing ER exit. ..
  41. Park D, Yu Y, Kim Y, Maeng P. Negative regulation of the vacuole-mediated resistance to K(+) stress by a novel C2H2 zinc finger transcription factor encoded by aslA in Aspergillus nidulans. J Microbiol. 2015;53:100-10 pubmed publisher
  42. Takeshita N, Wernet V, Tsuizaki M, Grün N, Hoshi H, Ohta A, et al. Transportation of Aspergillus nidulans Class III and V Chitin Synthases to the Hyphal Tips Depends on Conventional Kinesin. PLoS ONE. 2015;10:e0125937 pubmed publisher
    ..KinA co-immunoprecipitated with ChsB and CsmA. Co-localization and association of CsmA with KinA did not depend on the MMD. These findings indicate that ChsB and CsmA are transported along microtubules to the subapical region by KinA. ..
  43. Stevens L, McKinnon I. The effect of 1,4-diaminobutanone on the stability of ornithine decarboxylase from Aspergillus nidulans. Biochem J. 1977;166:635-7 pubmed
    ..It also protects ornithine decarboxylase against proteolysis by chymotrypsin in vitro. ..
  44. Hoang V, Jaklitsch W, Scrutton M. Adenylate kinase isoenzymes in Aspergillus nidulans. FEMS Microbiol Lett. 1991;62:133-7 pubmed
    ..The isoenzymes have similar Km values for AMP, ADP and MgATP2- but may differ in the mechanism used for internucleotide phosphate transfer. ..
  45. Flipphi M, Robellet X, Dequier E, Leschelle X, Felenbok B, Vélot C. Functional analysis of alcS, a gene of the alc cluster in Aspergillus nidulans. Fungal Genet Biol. 2006;43:247-60 pubmed
    ..Basic Local Alignment Search Tool analysis against the A. nidulans genome led to the identification of two novel ethanol- and ethylacetate-induced genes encoding other members of the GPR1/FUN34/YaaH family, AN5226 and AN8390. ..
  46. Lee D, Kim L, Kim J, Han K, Han D. Isolation and characterization of self-fertile suppressors from the sterile nsdD deletion mutant of Aspergillus nidulans. J Microbiol. 2011;49:1054-7 pubmed publisher
    ..The common phenotype of the suppressor mutants suggested the involvement of the snd genes in the negative regulation of sexual development in response to the environmental factors. ..
  47. Etxebeste O, Herrero Garcia E, Cortese M, Garzia A, Oiartzabal Arano E, de los Ríos V, et al. GmcA is a putative glucose-methanol-choline oxidoreductase required for the induction of asexual development in Aspergillus nidulans. PLoS ONE. 2012;7:e40292 pubmed publisher
    ..Overall, the results obtained in this work support a role for GmcA at early stages of conidiophore initiation. ..
  48. Kosti V, Lambrinidis G, Myrianthopoulos V, Diallinas G, Mikros E. Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family. PLoS ONE. 2012;7:e41939 pubmed publisher
  49. Colabardini A, Brown N, Savoldi M, Goldman M, Goldman G. Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK. PLoS ONE. 2013;8:e57630 pubmed publisher
    ..Transcriptional profiling of ypkA overexpression and down-regulation revealed several putative YpkA targets associated with the observed phenotypes...
  50. Dalrymple S, Ko J, Sheoran I, Kaminskyj S, Sanders D. Elucidation of substrate specificity in Aspergillus nidulans UDP-galactose-4-epimerase. PLoS ONE. 2013;8:e76803 pubmed publisher
    ..Docking studies designed to probe active site affinity corroborate the experimentally determined activity profiles and support the kinetic inhibition results. ..
  51. Egan M, McClintock M, Hollyer I, Elliott H, Reck Peterson S. Cytoplasmic dynein is required for the spatial organization of protein aggregates in filamentous fungi. Cell Rep. 2015;11:201-9 pubmed
    ..Finally, we find that impaired clearance of these inclusions negatively impacts retrograde trafficking of endosomes, a conventional dynein cargo, indicating that microtubule-based transport can be overwhelmed by chronic cellular stress. ..
  52. Alguel Y, Amillis S, Leung J, Lambrinidis G, Capaldi S, Scull N, et al. Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity. Nat Commun. 2016;7:11336 pubmed publisher
    ..We postulate that UapA uses an elevator transport mechanism likely to be shared with other structurally homologous transporters including anion exchangers and prestin. ..
  53. Paszewski A, Grabski J. Enzymatic lesions in methionine mutants of Aspergillus nidulans: role and regulation of an alternative pathway for cysteine and methionine synthesis. J Bacteriol. 1975;124:893-904 pubmed
    ..Homocysteine synthesized by this pathway serves as precursor for cysteine and methionine synthesis. A mutant with altered homocysteine synthase is a prototroph, indicating that this enzyme is not essential for the fungus. ..
  54. Bauer S, Vasu P, Persson S, Mort A, Somerville C. Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls. Proc Natl Acad Sci U S A. 2006;103:11417-22 pubmed publisher
    ..The analysis revealed a decrease in the abundance of xylan in the mutant, indicating that the IRX9 gene, which encodes a putative family 43 glycosyltransferase, is required for xylan synthesis...
  55. Katz M, Bernardo S, Cheetham B. The interaction of induction, repression and starvation in the regulation of extracellular proteases in Aspergillus nidulans: evidence for a role for CreA in the response to carbon starvation. Curr Genet. 2008;54:47-55 pubmed publisher
    ..This increase was XprG-dependent indicating that the effect of these genes may be through modulation of XprG activity...
  56. Ramamoorthy V, Shantappa S, Dhingra S, Calvo A. veA-dependent RNA-pol II transcription elongation factor-like protein, RtfA, is associated with secondary metabolism and morphological development in Aspergillus nidulans. Mol Microbiol. 2012;85:795-814 pubmed publisher
    ..This is the first study of an Rtf1 like gene in filamentous fungi. We found rtfA putative orthologues extensively conserved in numerous fungal species...
  57. Diallinas G. Allopurinol and xanthine use different translocation mechanisms and trajectories in the fungal UapA transporter. Biochimie. 2013;95:1755-64 pubmed publisher
    ..Our results are in line with recently accumulating evidence revealing atypical and complex mechanisms underlying transport systems...
  58. Lee J, Kim L, Kim H, Park J, Han K, Han D. A putative APSES transcription factor is necessary for normal growth and development of Aspergillus nidulans. J Microbiol. 2013;51:800-6 pubmed publisher
    ..However, the rgdA gene affected brlA and abaA expression, which function as key regulators of asexual sporulation, suggesting that rgdA functions upstream of those genes. ..
  59. Kellner N, Heimel K, Obhof T, Finkernagel F, Kämper J. The SPF27 homologue Num1 connects splicing and kinesin 1-dependent cytoplasmic trafficking in Ustilago maydis. PLoS Genet. 2014;10:e1004046 pubmed publisher
    ..As the num1 deletion also affects cytoplasmic mRNA transport, the protein may constitute a novel functional interconnection between the two disparate processes of splicing and trafficking. ..
  60. Shen K, Osmani A, Govindaraghavan M, Osmani S. Mitotic regulation of fungal cell-to-cell connectivity through septal pores involves the NIMA kinase. Mol Biol Cell. 2014;25:763-75 pubmed publisher
    ..The study provides insights into how and why cytoplasmically connected Aspergillus cells maintain mitotic autonomy. ..
  61. Park B, Park Y, Yi S, Choi Y, Kang E, Park H. Transcriptional regulation of fksA, a ?-1,3-glucan synthase gene, by the APSES protein StuA during Aspergillus nidulans development. J Microbiol. 2014;52:940-7 pubmed publisher
    ..Taken together, these data suggest that StuA plays an important role in cell wall biogenesis during the development of A. nidulans, by controlling the transcription level of fksA. ..
  62. Alam M, Kamlangdee N, Kelly J. The CreB deubiquitinating enzyme does not directly target the CreA repressor protein in Aspergillus nidulans. Curr Genet. 2017;63:647-667 pubmed publisher
    ..These results open up new questions regarding the molecular mechanism of CreA repressing activity, and how the ubiquitination pathway involving CreB interacts with this regulatory network. ..
  63. Eades C, Gilbert A, Goodman C, Hintz W. Identification and analysis of a class 2 alpha-mannosidase from Aspergillus nidulans. Glycobiology. 1998;8:17-33 pubmed
    ..29). These three enzymes were found to be distantly related to other Class 2 sequences, and compose a third subgroup of Class 2 alpha-mannosidases, as shown by ClustalW sequence alignment...
  64. Peña Montes C, Lange S, Flores I, Castro Ochoa D, Schmid R, Cruz García F, et al. Molecular characterization of StcI esterase from Aspergillus nidulans. Appl Microbiol Biotechnol. 2009;84:917-26 pubmed publisher
    ..We also detected the presence of this additional N-terminal region using reverse-transcriptase polymerase chain reaction. The complete protein (NStcI) was cloned and successfully expressed in Pichia pastoris. ..
  65. de Souza W, Morais E, Krohn N, Savoldi M, Goldman M, Rodrigues F, et al. Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans. PLoS ONE. 2013;8:e62088 pubmed publisher
    ..The data suggested an intimate relationship among different G-protein coupled receptors, fine-tune regulation of secondary and amino acid metabolisms, and fungal development. ..
  66. Alam M, Kelly J. Proteins interacting with CreA and CreB in the carbon catabolite repression network in Aspergillus nidulans. Curr Genet. 2017;63:669-683 pubmed publisher
    ..nidulans or human background analyses. Hir3 was present in repressing conditions for CreA and in both growth conditions for CreB, suggesting that Hir3, or proteins interacting with Hir3, could be a possible target of CreB. ..
  67. Fitzgibbon G, Morozov I, Jones M, Caddick M. Genetic analysis of the TOR pathway in Aspergillus nidulans. Eukaryot Cell. 2005;4:1595-8 pubmed publisher
    ..Unlike the situation in Saccharomyces cerevisiae, there is only a single Tor kinase, as in plant and animal systems, and mutant phenotypes suggest that the TOR pathway plays only a minor role in regulating nitrogen metabolism...
  68. Maggio Hall L, Lyne P, Wolff J, Keller N. A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans. Fungal Genet Biol. 2008;45:180-9 pubmed publisher
  69. Kriangkripipat T, Momany M. Aspergillus nidulans protein O-mannosyltransferases play roles in cell wall integrity and developmental patterning. Eukaryot Cell. 2009;8:1475-85 pubmed publisher
    ..nidulans Pmts modify proteins in the cell wall integrity pathway. The altered developmental patterns in Deltapmt mutants suggest that A. nidulans Pmts modify proteins that serve as spatial cues...
  70. Wang C, Shim W, Shaw B. Aspergillus nidulans striatin (StrA) mediates sexual development and localizes to the endoplasmic reticulum. Fungal Genet Biol. 2010;47:789-99 pubmed publisher
    ..By co-labeling with FM4-64 and co-localization with nuclear localized StuA(NLS)::DsRed or CxnA (an endoplasmic reticulum marker), we determined that StrA mainly localizes to endoplasmic reticulum and the nuclear envelope...
  71. Gournas C, Oestreicher N, Amillis S, Diallinas G, Scazzocchio C. Completing the purine utilisation pathway of Aspergillus nidulans. Fungal Genet Biol. 2011;48:840-8 pubmed publisher
    ..The identification of these additional genes confirms the complete absence of clustering of the genes involved in purine utilisation in A. nidulans...
  72. McGrath A, Mithieux S, Collyer C, Bakhuis J, van den Berg M, Sein A, et al. Structure and activity of Aspergillus nidulans copper amine oxidase. Biochemistry. 2011;50:5718-30 pubmed publisher
    ..The active site is the most open of any of those of the structurally characterized enzymes in the family and provides a ready explanation for its lysine oxidase-like activity...
  73. Wang S, Cao J, Liu X, Hu H, Shi J, Zhang S, et al. Putative calcium channels CchA and MidA play the important roles in conidiation, hyphal polarity and cell wall components in Aspergillus nidulans. PLoS ONE. 2012;7:e46564 pubmed publisher
    ..Our findings suggest that the high-affinity Ca(2+) channel may represent a viable and completely unexplored avenue to reduce conidiation in the Aspergilli...
  74. Yao X, Wang X, Xiang X. FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus. Mol Biol Cell. 2014;25:2181-9 pubmed publisher
    ..However, in the absence of HookA or FtsA, FhipA protein level is significantly reduced. Our results indicate that all three proteins in the FtsA/HookA/FhipA complex are important for dynein-mediated early endosome movement...
  75. Kinghorn J, Pateman J. Mutants of Aspergillus nidulans lacking nicotinamide adenine dinucleotide-specific glutamate dehydrogenase. J Bacteriol. 1976;125:42-7 pubmed
    ..The properties are described of the double mutants bearing the mutations gdhB1 and gdhA1 or tamA119, which have low NADP-GDH activity...
  76. Han S, Navarro J, Greve R, Adams T. Translational repression of brlA expression prevents premature development in Aspergillus. EMBO J. 1993;12:2449-57 pubmed
    ..Removing the microORF initiation codon leads to deregulated brlA expression, resulting in an inappropriate activation of development. We propose that one mechanism for developmental induction in A.nidulans involves translational control...
  77. Efimov V, Morris N. The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. J Cell Biol. 2000;150:681-8 pubmed
    ..In addition, NUDF coprecipitates with an epitope-tagged NUDE. The fact that NUDF and LIS1 interact with the same protein domain strengthens the notion that these two proteins are functionally related...
  78. Oberegger H, Zadra I, Schoeser M, Abt B, Parson W, Haas H. Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization. Biochem Soc Trans. 2002;30:781-3 pubmed
    ..The functional characterization of these genes will help to unravel the pathways involved in siderophore biosynthesis and uptake...
  79. Bruggeman J, Debets A, Hoekstra R. Selection arena in Aspergillus nidulans. Fungal Genet Biol. 2004;41:181-8 pubmed
    ..The selection arena ensures that reproductive energy is invested mainly in dikaryons and thus sexual spores of good genetic quality...
  80. Bauer S, Vasu P, Mort A, Somerville C. Cloning, expression, and characterization of an oligoxyloglucan reducing end-specific xyloglucanobiohydrolase from Aspergillus nidulans. Carbohydr Res. 2005;340:2590-7 pubmed publisher
    ..The enzyme has a specific activity of 7 U/mg at the pH optimum of 3 and at the temperature optimum of 42 degrees C...
  81. Malavazi I, Semighini C, Kress M, Harris S, Goldman G. Regulation of hyphal morphogenesis and the DNA damage response by the Aspergillus nidulans ATM homolog AtmA. Genetics. 2006;173:99-109 pubmed publisher
    ..Our results suggest that AtmA regulates the function and/or localization of landmark proteins required for the formation of a polarity axis. We propose that a similar function may contribute to the establishment of neuronal polarity...
  82. Semighini C, Savoldi M, Goldman G, Harris S. Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA. Genetics. 2006;173:87-98 pubmed publisher
    ..Collectively, our results provide a gateway for probing the diverse functions of PARP in a sophisticated microbial genetic system...
  83. Mogensen J, Nielsen H, Hofmann G, Nielsen J. Transcription analysis using high-density micro-arrays of Aspergillus nidulans wild-type and creA mutant during growth on glucose or ethanol. Fungal Genet Biol. 2006;43:593-603 pubmed publisher
  84. Bernreiter A, Ramon A, Fern ndez Mart nez J, Berger H, Ara jo Bazan L, Espeso E, et al. Nuclear export of the transcription factor NirA is a regulatory checkpoint for nitrate induction in Aspergillus nidulans. Mol Cell Biol. 2007;27:791-802 pubmed publisher
  85. Kim Y, Nandakumar M, Marten M. Proteome map of Aspergillus nidulans during osmoadaptation. Fungal Genet Biol. 2007;44:886-95 pubmed publisher
    ..There also was an increased expression of heat shock proteins and Shp1-like protein degradation protein, implicating increased protein turnover. Five novel osmoadaptation proteins of unknown functions were also identified...
  86. Belaish R, Sharon H, Levdansky E, Greenstein S, Shadkchan Y, Osherov N. The Aspergillus nidulans cetA and calA genes are involved in conidial germination and cell wall morphogenesis. Fungal Genet Biol. 2008;45:232-42 pubmed publisher
    ..nidulans conidial germination. We show that CETA and CALA are secreted proteins that together play an essential role in early conidial germination...
  87. Paukstelis P, Lambowitz A. Identification and evolution of fungal mitochondrial tyrosyl-tRNA synthetases with group I intron splicing activity. Proc Natl Acad Sci U S A. 2008;105:6010-5 pubmed publisher
    ..The unique group I intron splicing activity of these fungal enzymes may provide a new target for antifungal drugs...
  88. Berger H, Basheer A, B ck S, Reyes Dominguez Y, Dalik T, Altmann F, et al. Dissecting individual steps of nitrogen transcription factor cooperation in the Aspergillus nidulans nitrate cluster. Mol Microbiol. 2008;69:1385-98 pubmed publisher
    ..Continuous nitrate assimilation leads to self-nitrogen metabolite repression but nitrate-activated NirA is partially compensating for lowered AreA activities under these conditions...
  89. Panagiotou G, Grotkjaer T, Hofmann G, Bapat P, Olsson L. Overexpression of a novel endogenous NADH kinase in Aspergillus nidulans enhances growth. Metab Eng. 2009;11:31-9 pubmed publisher
    ..This conclusion may impact the design of new strains capable of generating reducing power in the form of NADPH, which is crucial for efficient production of many industrially important metabolites and enzymes...
  90. Perales Clemente E, Bayona Bafaluy M, P rez Martos A, Barrientos A, Fern ndez Silva P, Enriquez J. Restoration of electron transport without proton pumping in mammalian mitochondria. Proc Natl Acad Sci U S A. 2008;105:18735-9 pubmed publisher
  91. Oestreicher N, Scazzocchio C. Phenotypes of mutations in the 5'-UTR of a limiting transcription factor in Aspergillus nidulans can be accounted for by translational inhibition and leaky scanning. Genetics. 2009;181:1261-72 pubmed publisher
    ..The first-AUG rule and the phenomena of translational inhibition and leaky scanning provide a coherent explanation of the results presented in this article...
  92. Bok J, Chiang Y, Szewczyk E, Reyes Dominguez Y, Davidson A, Sanchez J, et al. Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol. 2009;5:462-4 pubmed publisher
    ..Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters...
  93. De Groot P, Brandt B, Horiuchi H, Ram A, de Koster C, Klis F. Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans. Fungal Genet Biol. 2009;46 Suppl 1:S72-81 pubmed
    ..nidulans, including ten predicted GPI proteins, most of which belong to carbohydrate-active enzyme families that are also found in the walls of ascomycetous yeasts...
  94. Gournas C, Amillis S, Vlanti A, Diallinas G. Transport-dependent endocytosis and turnover of a uric acid-xanthine permease. Mol Microbiol. 2010;75:246-60 pubmed publisher
    ..Finally, we demonstrate that in the presence of substrates, non-functional UapA versions can be endocytosed in trans if expressed in the simultaneous presence of active UapA versions, even if the latter cannot be endocytosed themselves...
  95. Fekete E, Karaffa L, Seiboth B, Fekete E, Kubicek C, Flipphi M. Identification of a permease gene involved in lactose utilisation in Aspergillus nidulans. Fungal Genet Biol. 2012;49:415-25 pubmed publisher
    ..The effect of lacpA gene deletion on lactose uptake was exacerbated at lower substrate concentrations, evidence for the existence of a second transport system with a lower affinity for this disaccharide in A. nidulans...
  96. Bromann K, Toivari M, Viljanen K, Vuoristo A, Ruohonen L, Nakari Set l T. Identification and characterization of a novel diterpene gene cluster in Aspergillus nidulans. PLoS ONE. 2012;7:e35450 pubmed publisher
    ..These results identify the first Aspergillus nidulans diterpene gene cluster and suggest a biosynthetic pathway for ent-pimara-8(14),15-diene...
  97. Ahuja M, Chiang Y, Chang S, Praseuth M, Entwistle R, Sanchez J, et al. Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans. J Am Chem Soc. 2012;134:8212-21 pubmed publisher
    ..This has allowed us to determine the products of eight NR-PKSs of Aspergillus nidulans, including seven novel compounds, as well as the NR-PKS genes required for the synthesis of the toxins alternariol (8) and cichorine (19)...
  98. Bayram z, Bayram z, Ahmed Y, Maruyama J, Valerius O, Rizzoli S, et al. The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. PLoS Genet. 2012;8:e1002816 pubmed publisher
    ..Our data suggest that not only Fus3, but even the entire MAPK module complex of four physically interacting proteins, can migrate from plasma membrane to nuclear envelope...
  99. Lee S, Shaw B. A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis. Mol Microbiol. 2007;63:1039-53 pubmed publisher
    ..This is the first report linking N-myristoylation and ubiquitin-proteasome-dependent proteolysis during morphogenesis...
  100. Helmstaedt K, Laubinger K, Vosskuhl K, Bayram O, Busch S, Hoppert M, et al. The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies. Eukaryot Cell. 2008;7:1041-52 pubmed publisher
    ..These results show that the conserved NUDF and NUDC proteins play a concerted role at SPBs at different stages of the cell cycle and that NUDF recruits additional proteins specifically to the dynein complex at SPBs...
  101. Shimizu M, Fujii T, Masuo S, Takaya N. Mechanism of de novo branched-chain amino acid synthesis as an alternative electron sink in hypoxic Aspergillus nidulans cells. Appl Environ Microbiol. 2010;76:1507-15 pubmed publisher
    ..These indicated that hypoxic branched-chain amino acid synthesis is a unique alternative mechanism that functions in the absence of glucose-to-ethanol/lactate fermentation and oxygen respiration...