Aspergillus niger CBS 513.88



Top Publications

  1. Liao J, Okuyama M, Ishihara K, Yamori Y, Iki S, Tagami T, et al. Kinetic properties and substrate inhibition of α-galactosidase from Aspergillus niger. Biosci Biotechnol Biochem. 2016;80:1747-52 pubmed publisher
    ..A sequence comparison suggested that AglB had a shallow active-site pocket, and it can allow to hydrolyze the branched α-galactosides, but not linear raffinose family oligosaccharides. ..
  2. Kwon M, Jørgensen T, Nitsche B, Arentshorst M, Park J, Ram A, et al. The transcriptomic fingerprint of glucoamylase over-expression in Aspergillus niger. BMC Genomics. 2012;13:701 pubmed publisher
    ..niger. The consistent up-regulation of a gene encoding the acetyl-coenzyme A transporter suggests a possible role for transient acetylation to ensure correct folding of secreted proteins. ..
  3. Mrázek H, Benada O, Man P, Vaněk O, Křen V, Bezouška K, et al. Facile production of Aspergillus niger α-N-acetylgalactosaminidase in yeast. Protein Expr Purif. 2012;81:106-114 pubmed publisher
    ..N-Glycosylation was confirmed at six of the eight potential N-glycosylation sites in both wild type and recombinant α-GalNAc-ase. ..
  4. Walvekar A, Choudhury R, Punekar N. Mixed disulfide formation at Cys141 leads to apparent unidirectional attenuation of Aspergillus niger NADP-glutamate dehydrogenase activity. PLoS ONE. 2014;9:e101662 pubmed publisher
    ..In sum, although Cys141 is catalytically not essential, its covalent modification provides a striking example of converting the biosynthetic AnGDH into a catabolic enzyme. ..
  5. Dinarvand M, Rezaee M, Masomian M, Jazayeri S, Zareian M, Abbasi S, et al. Effect of C/N ratio and media optimization through response surface methodology on simultaneous productions of intra- and extracellular inulinase and invertase from Aspergillus niger ATCC 20611. Biomed Res Int. 2013;2013:508968 pubmed publisher
    ..2 to 1.3 times greater than in the medium optimized by one-factor-at-a-time, respectively. The results of bioprocesses optimization can be useful in the scale-up fermentation and food industry. ..
  6. Liu L, Sun X, Yan P, Wang L, Chen H. Non-structured amino-acid impact on GH11 differs from GH10 xylanase. PLoS ONE. 2012;7:e45762 pubmed publisher
    ..The impact of non-structured residues on GH11 xylanase was different from that of similar residues on GH10 xylanase, and the difference is attributed to structural difference between GH11 jelly-roll and GH10 (?/?)(8). ..
  7. Keni S, Punekar N. Contribution of arginase to manganese metabolism of Aspergillus niger. Biometals. 2016;29:95-106 pubmed publisher
    ..The relevance of arginase to cellular Mn[II] pool and homeostasis was evaluated and the results suggest that arginase regulation could occur via manganese availability. ..
  8. Prakash P, Walvekar A, Punekar N, Bhaumik P. Purification, crystallization and preliminary X-ray diffraction analysis of NADP-dependent glutamate dehydrogenase from Aspergillus niger. Acta Crystallogr F Struct Biol Commun. 2014;70:1508-12 pubmed publisher
    ..0%) and had only one molecule in the asymmetric unit. Initial phases were obtained by molecular replacement, and model building and structure refinement of AnGDH are in progress. ..
  9. Dilokpimol A, Mäkelä M, Mansouri S, Belova O, Waterstraat M, Bunzel M, et al. Expanding the feruloyl esterase gene family of Aspergillus niger by characterization of a feruloyl esterase, FaeC. N Biotechnol. 2017;37:200-209 pubmed publisher
    ..This may increase the efficiency of the degradation of diverse plant biomass. ..

More Information


  1. Zhang J, Zhu L, Chen H, Li M, Zhu X, Gao Q, et al. A Polyketide Synthase Encoded by the Gene An15g07920 Is Involved in the Biosynthesis of Ochratoxin A in Aspergillus niger. J Agric Food Chem. 2016;64:9680-9688 pubmed publisher
    ..niger but also provide necessary information for the development of effective diagnostic, preventive, and control strategies to reduce the risk of OTA contamination in foods. ..
  2. Sakaki Y, Tashiro M, Katou M, Sakuma C, Hirano T, Hakamata W, et al. Enzymatic synthesis of novel oligosaccharides from N-acetylsucrosamine and melibiose using Aspergillus niger ?-galactosidase, and properties of the products. Biosci Biotechnol Biochem. 2016;80:1836-42 pubmed publisher
    ..These results indicate that the physicochemical properties and steric structure of RafNAc differ considerably from those of Raf. ..
  3. Jin H, OuYang X, Hu Z. Enhancement of epoxide hydrolase production by 60 Co gamma and UV irradiation mutagenesis of Aspergillus niger ZJB-09103. Biotechnol Appl Biochem. 2017;64:392-399 pubmed publisher
    ..This phenomenon was probably explained by the higher Vmax for hydrolysis of racemic epichlorohydrin by C2-44 compared with Aspergillus niger ZJB-09103. ..
  4. Noorbatcha I, Sultan A, Salleh H, Amid A. Understanding thermostability factors of Aspergillus niger PhyA phytase: a molecular dynamics study. Protein J. 2013;32:309-16 pubmed publisher
    ..The results also show that salt bridges may have stabilizing or destabilizing effect on the enzyme and influence its thermostability accordingly...
  5. van Munster J, Nitsche B, Krijgsheld P, van Wijk A, Dijkhuizen L, W sten H, et al. Chitinases CtcB and CfcI modify the cell wall in sporulating aerial mycelium of Aspergillus niger. Microbiology. 2013;159:1853-67 pubmed publisher
    ..niger cell walls during sporulation. These novel insights in the sporulation process in aspergilli are of strong scientific relevance, and also may aid industrial strain engineering...
  6. Kotaka M, Johnson C, Lamb H, Hawkins A, Ren J, Stammers D. Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA. J Mol Biol. 2008;381:373-82 pubmed publisher
    ..Thus, any regulatory effects on AreA function mediated by the binding of oxidised nicotinamide dinucleotides to NmrA in the NmrA-AreA ZF complex appear not to be modulated via protein conformational rearrangements...
  7. Gruben B, Zhou M, de Vries R. GalX regulates the D-galactose oxido-reductive pathway in Aspergillus niger. FEBS Lett. 2012;586:3980-5 pubmed publisher
    ..Phenotypic and gene expression analysis of a wild type and a galX disruptant revealed that GalX regulates the d-galactose oxido-reductive pathway, but not the Leloir pathway in A. niger...
  8. Mojzita D, Herold S, Metz B, Seiboth B, Richard P. L-xylo-3-hexulose reductase is the missing link in the oxidoreductive pathway for D-galactose catabolism in filamentous fungi. J Biol Chem. 2012;287:26010-8 pubmed publisher
    ..0 ± 0.5 mm and a V(max) = 5.5 ± 1.0 units/mg. We also confirmed that the product of the LXR4 reaction is D-sorbitol...
  9. Schachtschabel D, Arentshorst M, Lagendijk E, Ram A. Vacuolar H(+)-ATPase plays a key role in cell wall biosynthesis of Aspergillus niger. Fungal Genet Biol. 2012;49:284-93 pubmed publisher
    ..Our results indicate that the ATP-driven transport of protons and acidification of the vacuole is crucial for the strength of the fungal cell wall and that reduced activity of the V-ATPase induces the cell wall stress response pathway...
  10. Oakley A. The structure of Aspergillus niger phytase PhyA in complex with a phytate mimetic. Biochem Biophys Res Commun. 2010;397:745-9 pubmed publisher
    ..The new structures of A. niger PhyA are discussed in the context of protein engineering studies aimed at modulating pH preference and stability...
  11. Reetz M, Bocola M, Wang L, Sanchis J, Cronin A, Arand M, et al. Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage. J Am Chem Soc. 2009;131:7334-43 pubmed publisher
    ..Predictions regarding substrate scope and enantioselectivity of the best mutant are shown to be possible...
  12. Wadman M, de Vries R, Kalkhove S, Veldink G, Vliegenthart J. Characterization of oxylipins and dioxygenase genes in the asexual fungus Aspergillus niger. BMC Microbiol. 2009;9:59 pubmed publisher
    ..nidulans. Their presence could point towards the existence of sexual reproduction in A. niger or a broader role for the gene products in physiology, than just sexual development...