Aspergillus flavus NRRL3357



Top Publications

  1. Chang P, Scharfenstein L, Li R, Arroyo Manzanares N, De Saeger S, Diana Di Mavungu J. Aspergillus flavus aswA, a gene homolog of Aspergillus nidulans oefC, regulates sclerotial development and biosynthesis of sclerotium-associated secondary metabolites. Fungal Genet Biol. 2017;104:29-37 pubmed publisher
    ..Impairment in aswA gene function stalls normal sclerotial development, which in turn prevents biosynthesis and accumulation of sclerotium-specific metabolites. ..
  2. Zhi Q, Li J, Liu Q, He Z. A cytosine methyltransferase ortholog dmtA is involved in the sensitivity of Aspergillus flavus to environmental stresses. Fungal Biol. 2017;121:501-514 pubmed publisher
    ..Our results indicate that the dmtA gene is important in regulation of aflatoxin biosynthesis and for A. flavus to adapt to stressful environments and for survival, although it may hold no apparent function in DNA methylation. ..
  3. Inamdar S, Joshi S, Bapat V, Jadhav J. Purification and characterization of RNA allied extracellular tyrosinase from Aspergillus species. Appl Biochem Biotechnol. 2014;172:1183-93 pubmed publisher
    ..Copper sulphate and magnesium chloride enhanced the activity whereas in contrast FeCl? inhibited the activity completely. Purified tyrosinase transformed L-tyrosine (5 mM) to L-DOPA within 5 h. ..
  4. Colloc h N, Prangé T. Functional relevance of the internal hydrophobic cavity of urate oxidase. FEBS Lett. 2014;588:1715-9 pubmed publisher
    ..This cavity would act as a connecting vessel to give flexibility to the neighboring active site, and its expansion under pure oxygen pressure reveals that it might serve as a transient reservoir on its pathway to the active site. ..
  5. Satterlee T, Cary J, Calvo A. RmtA, a Putative Arginine Methyltransferase, Regulates Secondary Metabolism and Development in Aspergillus flavus. PLoS ONE. 2016;11:e0155575 pubmed publisher
  6. Yang K, Liang L, Ran F, Liu Y, Li Z, Lan H, et al. The DmtA methyltransferase contributes to Aspergillus flavus conidiation, sclerotial production, aflatoxin biosynthesis and virulence. Sci Rep. 2016;6:23259 pubmed publisher
    ..Thus, our findings suggest that DmtA, apart from being a C-5 cytosine methyltransferase in A. flavus, contributes to asexual development, aflatoxin biosynthesis, sclerotial production and virulence. ..
  7. Cary J, Han Z, Yin Y, Lohmar J, Shantappa S, Harris Coward P, et al. Transcriptome Analysis of Aspergillus flavus Reveals veA-Dependent Regulation of Secondary Metabolite Gene Clusters, Including the Novel Aflavarin Cluster. Eukaryot Cell. 2015;14:983-97 pubmed publisher
    ..Interestingly, our results indicate that the cluster is expressed mainly in sclerotia. Chemical analysis of sclerotial extracts revealed that cluster 39 is responsible for the production of aflavarin. ..
  8. Tanaka T, Tanabe H, Uehara K, Takahashi T, Abe K. Involvement of hydrophobic amino acid residues in C7-C8 loop of Aspergillus oryzae hydrophobin RolA in hydrophobic interaction between RolA and a polyester. Biosci Biotechnol Biochem. 2014;78:1693-9 pubmed publisher
    ..QCM analysis revealed that mutants with replacements in the Cys7-Cys8 loop had lower affinity than wild-type RolA for PBSA, suggesting that this loop is involved in RolA adsorption on PBSA. ..
  9. Cary J, Harris Coward P, Ehrlich K, Di Mavungu J, Malysheva S, De Saeger S, et al. Functional characterization of a veA-dependent polyketide synthase gene in Aspergillus flavus necessary for the synthesis of asparasone, a sclerotium-specific pigment. Fungal Genet Biol. 2014;64:25-35 pubmed publisher
    ..To our knowledge this is the first report on the genes involved in the biosynthesis of pigments important for sclerotial survival. ..

More Information


  1. Mahmud A, Hattori K, Hongwen C, Kitamoto N, Suzuki T, Nakamura K, et al. NAD?-dependent xylitol dehydrogenase (xdhA) and L-arabitol-4-dehydrogenase (ladA) deletion mutants of Aspergillus oryzae for improved xylitol production. Biotechnol Lett. 2013;35:769-77 pubmed publisher
    ..xdhA, ladA, and the double-deletion mutant produced, respectively, 12.4 g xylitol/l with a yield of 0.24 g/g D-xylose, 12.4 g/l with a yield of 0.33 g/g D-xylose, and 8.6 g/l at a yield of 0.26 g/g D-xylose. ..
  2. Collings I, Watier Y, Giffard M, Dagogo S, Kahn R, Bonneté F, et al. Polymorphism of microcrystalline urate oxidase from Aspergillus flavus. Acta Crystallogr D Biol Crystallogr. 2010;66:539-48 pubmed publisher
    ..The outcome of our analysis verifies previously reported results as well as demonstrating polymorphs that have altered unit-cell dimensions with respect to known structural models. ..
  3. Chang P, Scharfenstein L, Ehrlich K, Diana Di Mavungu J. The Aspergillus flavus fluP-associated metabolite promotes sclerotial production. Fungal Biol. 2016;120:1258-68 pubmed publisher
    ..These results suggest that FluP polyketide synthase is involved in the synthesis of a diffusible metabolite that could serve as a signal molecule to regulate sclerotiogenesis. ..
  4. Seshime Y, Juvvadi P, Tokuoka M, Koyama Y, Kitamoto K, Ebizuka Y, et al. Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid. Bioorg Med Chem Lett. 2009;19:3288-92 pubmed publisher
    ..This CpaA expression system provides us an ideal platform for PKS-NRPS functional analysis, such as adenylation domain selectivity and product releasing mechanism...
  5. Baidya S, Duran R, Lohmar J, Harris Coward P, Cary J, Hong S, et al. VeA is associated with the response to oxidative stress in the aflatoxin producer Aspergillus flavus. Eukaryot Cell. 2014;13:1095-103 pubmed publisher
    ..Our study also revealed that veA positively influences the expression of the transcription factor gene atfB and that normal formation of DNA-protein complexes in the cat1 promoter is dependent on AtfB...
  6. Cary J, Harris Coward P, Ehrlich K, Mack B, Kale S, Larey C, et al. NsdC and NsdD affect Aspergillus flavus morphogenesis and aflatoxin production. Eukaryot Cell. 2012;11:1104-11 pubmed publisher
    ..Our results support previous studies showing that there is a strong association between conidiophore and sclerotium development and aflatoxin production in A. flavus...
  7. Marassio G, Prang T, David H, Santos J, Gabison L, Delcroix N, et al. Pressure-response analysis of anesthetic gases xenon and nitrous oxide on urate oxidase: a crystallographic study. FASEB J. 2011;25:2266-75 pubmed publisher
  8. Liu X, Walsh C. Characterization of cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase in cyclopiazonic acid biosynthesis: substrate promiscuity and site directed mutagenesis studies. Biochemistry. 2009;48:11032-44 pubmed publisher
    ..Subsequent site-directed mutagenesis studies identified five polar/charged residues and five tyrosine residues within these motifs that are critical for CpaD activity...
  9. Liu X, Walsh C. Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan. Biochemistry. 2009;48:8746-57 pubmed publisher
    ..It is likely that cyclization of beta-ketoacylaminoacyl-S-pantetheinyl intermediates to released tetramates represents a default cyclization/release route for redox-incompetent R* domains embedded in NRPS assembly lines...