Genomes and Genes
Candida albicans SC5314
Publications139 found, 100 shown here
- Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cellsQuynh T Phan
Department of Medicine, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, United States of America
PLoS Biol 5:e64. 2007..These results uncover the first known fungal invasin and provide evidence that C. albicans Als3 is a molecular mimic of human cadherins...
- The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophilsAnke Hornbach
Institute of Hygiene and Microbiology, University of Wurzburg, 97080 Wurzburg, Germany
Infect Immun 77:5216-24. 2009..albicans. These data clearly implicate Sap9 protease activity in the initiation of protective innate immunity and suggest novel molecular mechanisms in C. albicans-host interaction leading to neutrophil activation...
- Heterogeneous distribution of Candida albicans cell-surface antigens demonstrated with an Als1-specific monoclonal antibodyDavid A Coleman
Department of Pathobiology, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
Microbiology 156:3645-59. 2010..albicans cell surface, and the differences in Als1 localization that occur in vitro and in vivo...
- Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulencePatricia L Carlisle
Department of Microbiology and Immunology, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7758, San Antonio, TX 78229 3900, USA
Proc Natl Acad Sci U S A 106:599-604. 2009..These findings suggest that a common transcriptional regulatory mechanism functions to specify both pseudohyphal and hyphal morphologies in a dosage-dependent manner...
- Candida albicans adhesin Als3p is dispensable for virulence in the mouse model of disseminated candidiasisIan A Cleary
Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
Microbiology 157:1806-15. 2011..Finally, in a murine model of haematogenously disseminated candidiasis the mutant als3Δ remained as virulent as the wild-type parent strain...
- Iron deprivation induces EFG1-mediated hyphal development in Candida albicans without affecting biofilm formationSaif Hameed
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
FEMS Yeast Res 8:744-55. 2008..albicans cells. Our study, for the first time, establishes a link between cellular iron, Efg1p and hyphal development of C. albicans cells that is independent of biofilm formation...
- A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicansAlix Coste
Institute of Microbiology, University Hospital Lausanne, Switzerland
Genetics 172:2139-56. 2006....
- The Yak1 kinase is involved in the initiation and maintenance of hyphal growth in Candida albicansSophie Goyard
Unité Biologie et Pathogénicité Fongiques, Institut National de la Recherche Agronomique USC2019, Paris, France
Mol Biol Cell 19:2251-66. 2008....
- The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicansFrancisco J Alvarez
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
Mol Biol Cell 19:5214-25. 2008....
- Candida albicans cells lacking CaMCA1-encoded metacaspase show resistance to oxidative stress-induced death and change in energy metabolismYingying Cao
School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China
Fungal Genet Biol 46:183-9. 2009..Our results suggest that CaMCA1 might mediate the sensitiveness to oxidative stress by affecting energy metabolism in C. albicans...
- Candida albicans Cyr1, Cap1 and G-actin form a sensor/effector apparatus for activating cAMP synthesis in hyphal growthHao Zou
Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore
Mol Microbiol 75:579-91. 2010..Furthermore, G-actin's regulatory role in this apparatus may prove to be the missing link whereby cellular actin status knowingly influences cAMP-mediated cellular processes...
- Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombinationEun Young Yu
Department of Microbiology and Immunology, W R Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Ave, New York, New York 10021, USA
Mol Cell Biol 30:1254-68. 2010..Our findings provide insights on the evolution and mechanistic plasticity of a widely conserved and functionally critical telomere component...
- A contact-activated kinase signals Candida albicans invasive growth and biofilm developmentCarol A Kumamoto
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 102:5576-81. 2005..Because responding to contact appropriately allows coordinated cellular behavior in a metazoan, commensal C. albicans cells behave like a part of the host, using contact-activated signaling to regulate fungal behavior...
- Carbon Source-dependent assembly of the Snf1p kinase complex in Candida albicansCarsten Corvey
Institute for Microbiology, Johann Wolfgang Goethe University of Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
J Biol Chem 280:25323-30. 2005..Yeast two-hybrid analysis confirmed the interaction partners, and these results showed an activator domain for the CaKis2 protein that has not been reported for S. cerevisiae scaffold subunits...
- Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicansDonika Kunze
Robert Koch Institut, Nordufer 20, D 13353, Berlin, Germany
Microbiology 151:3381-94. 2005..These data suggest that C. albicans contains two different classes of phospholipases C which are involved in cellular processes but which have no specific functions in pathogenicity...
- The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicansElvira Roman
Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s n, E 28040 Madrid, Spain
Mol Cell Biol 25:10611-27. 2005..These results reveal a role for the Sho1 protein in linking oxidative stress, cell wall biogenesis, and morphogenesis in this important human fungal pathogen...
- Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivoClarissa J Nobile
Department of Microbiology, Columbia University, New York, New York, USA
PLoS Pathog 2:e63. 2006..Known adhesins Als1 and Hwp1 also contribute to biofilm formation, as does the novel protein Ece1...
- Regulation of Cdc42 GTPase activity in the formation of hyphae in Candida albicansHelen Court
Department of Molecular Biology and Biotechnology, Sheffield University, Sheffield S10 2TN, United Kingdom
Mol Biol Cell 18:265-81. 2007..These results suggest the development of hyphal-specific characteristics is promoted by Cdc42-GTP in a process that also requires the intrinsic GTPase activity of Cdc42...
- Mutual dependence of Candida albicans Est1p and Est3p in telomerase assembly and activationMin Hsu
Department of Microbiology and Immunology, W R Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Eukaryot Cell 6:1330-8. 2007..We also developed an affinity isolation and an in vitro reconstitution protocol for the telomerase complex that will facilitate future mechanistic studies...
- Ribosomal protein genes in the yeast Candida albicans may be activated by a heterodimeric transcription factor related to Ino2 and Ino4 from S. cerevisiaeJens Hoppen
Institut für Genetik und Funktionelle Genomforschung, Ernst Moritz Arndt Universitat Greifswald, Jahnstr 15a, 17487 Greifswald, Germany
Mol Genet Genomics 278:317-30. 2007..Since we failed to obtain homozygous deletion mutations for CaINO2 and CaINO4, we conclude that CaIno2 and CaIno4 acquired new essential target genes among which may be ribosomal protein genes...
- The role of Candida albicans FAR1 in regulation of pheromone-mediated mating, gene expression and cell cycle arrestPierre Cote
Genetics Group, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec, Canada H4P 2R2
Mol Microbiol 68:392-404. 2008..Thus the C. albicans FAR1 gene is a dosage-dependent regulator of the pheromone response, and is critically required for all aspects of mating process of this pathogenic fungus...
- Regulation of the Candida albicans cell wall damage response by transcription factor Sko1 and PAS kinase Psk1Jason M Rauceo
Department of Microbiology and Institute of Cancer Research, Columbia University, New York, NY 10032, USA
Mol Biol Cell 19:2741-51. 2008..Our results show that protein kinase Psk1 is required for expression of SKO1 and of Sko1-dependent genes in response to caspofungin. Thus Psk1 and Sko1 lie in a newly described signal transduction pathway...
- Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicansYang Lu
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, SIBS, Chinese Academy of Sciences, Shanghai 200031, China
Mol Biol Cell 19:4260-72. 2008....
- Uptake of the antifungal cationic peptide Histatin 5 by Candida albicans Ssa2p requires binding to non-conventional sites within the ATPase domainJianing N Sun
Department of Oral Biology, School of Dental Medicine, Public Health and Health Professions and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
Mol Microbiol 70:1246-60. 2008..Thus, C. albicans Ssa2p binds Hst 5 at a surface-localized epitope in a subunit of the ATPase domain; and this region is required for intracellular translocation and killing functions of Hst 5...
- Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicansAdnane Sellam
Biotechnology Research Institute, National Research Council of Canada, Montreal, QC, H4P 2R2, Canada
Mol Biol Cell 20:2389-400. 2009..Furthermore, ADA2 deletion causes a decrease in H3K9 acetylation levels of target genes, thus illustrating its importance for histone acetyl transferase activity...
- Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicansDeming Xu
Center of Fungal Genetics, Merck Frosst Canada Ltd, Montreal, Quebec H9H 3L1, Canada
J Biol Chem 284:19754-64. 2009....
- Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genesAllen Wang
Department of Biological Chemistry, University of California, Irvine, CA 92697 1700, USA
Mol Cell Biol 29:4406-16. 2009..Efg1 also displays preferential association with Ace2 target gene promoters during hyphal growth. We show that convergent regulation of Ace2 and Efg1 defines the transcriptional program of cell chain formation...
- Role of Ndt80p in sterol metabolism regulation and azole resistance in Candida albicansAdnane Sellam
Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
Eukaryot Cell 8:1174-83. 2009..albicans...
- Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicansElvira Roman
Departamento de Microbiologia II, Universidad Complutense de Madrid, Spain
Eukaryot Cell 8:1235-49. 2009..albicans and suggest the divergence and specialization of this signaling pathway in filamentous fungi...
- Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulenceJennifer L Reedy
Department of Molecular Genetics and Microbiology, Duke University, Box 3546 Research Drive, 322 CARL Bldg, Durham, NC 27710, USA
Fungal Genet Biol 47:107-16. 2010..These studies extend our understanding of the C. albicans calcineurin signaling cascade and its host-niche specific role in virulence...
- Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animalsSusan Nicholls
Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK
Mol Microbiol 74:844-61. 2009..albicans. Therefore, the main role of Hsf1 in this pathogen might be the homeostatic modulation of chaperone levels in response to growth temperature, rather than the activation of acute responses to sudden thermal transitions...
- Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface proteinShanshan Luo
Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
Mol Immunol 47:541-50. 2009..As a released protein, Pra1 enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack...
- Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesisJessica Lopes da Rosa
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Proc Natl Acad Sci U S A 107:1594-9. 2010..We conclude that Rtt109 is particularly important for fungal pathogenicity, suggesting a unique target for therapeutic antifungal compounds...
- Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicansYing Lien Chen
Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
Mol Microbiol 75:1112-32. 2010..Cho1p is conserved in fungi, but not mammals, so fungal PS synthase is a potential novel antifungal drug target...
- Role of the homologous recombination genes RAD51 and RAD59 in the resistance of Candida albicans to UV light, radiomimetic and anti-tumor compounds and oxidizing agentsFátima García-Prieto
Departamento de Microbiologia, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain
Fungal Genet Biol 47:433-45. 2010..cerevisiae, RAD52 plays a more prominent role than RAD51 in the repair of DSBs in C. albicans and suggest the existence of at least two Rad52-dependent HR pathways, one dependent and one independent of Rad51...
- The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicansRebeca Alonso-Monge
Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s n, E 28040 Madrid, Spain
Fungal Genet Biol 47:587-601. 2010..Collectively, these results implicate Sko1 as an important mediator of the oxidative stress response in C. albicans...
- Candida albicans Hyr1p confers resistance to neutrophil killing and is a potential vaccine targetGuanpingsheng Luo
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90502, USA
J Infect Dis 201:1718-28. 2010..albicans, mediating resistance to phagocyte killing. Hyr1p is a promising target for vaccine or other immunological or small molecule intervention to improve the outcomes of disseminated candidiasis...
- Mds3 regulates morphogenesis in Candida albicans through the TOR pathwayLucia F Zacchi
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Mol Cell Biol 30:3695-710. 2010..Finally, we found that Mds3 and Sit4 coimmunoprecipitate. Thus, Mds3 is a new member of the TOR pathway that contributes to morphogenesis in C. albicans as a regulator of this key morphogenetic pathway...
- The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicansDenes Hnisz
Medical University Vienna, Christian Doppler Laboratory for Infection Biology, Max F Perutz Laboratories, Vienna, Austria
PLoS Pathog 6:e1000889. 2010..Hence, our work supports a paradigm for manipulating morphogenesis in C. albicans through alternative antifungal therapeutic strategies...
- Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicansAlessandra da Silva Dantas
Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH, United Kingdom
Mol Cell Biol 30:4550-63. 2010..albicans systemic infection. Collectively, our data indicate that Trx1 has a multifaceted role in H(2)O(2) signaling and promotes C. albicans survival in the host...
- The transcriptional regulator Nrg1p controls Candida albicans biofilm formation and dispersionPriya Uppuluri
Department of Biology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, USA
Eukaryot Cell 9:1531-7. 2010..Our results demonstrate that manipulation of NRG1 gene expression has a profound influence on biofilm formation and biofilm dispersal, thus identifying Nrg1p as a key regulator of the C. albicans biofilm life cycle...
- PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90Shantelle L LaFayette
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
PLoS Pathog 6:e1001069. 2010....
- Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10Lydia Schild
Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
Eukaryot Cell 10:98-109. 2011..albicans by human macrophages. We propose that Sap9 and Sap10 influence distinct cell wall functions by proteolytic cleavage of covalently linked cell wall proteins...
- CaMtw1, a member of the evolutionarily conserved Mis12 kinetochore protein family, is required for efficient inner kinetochore assembly in the pathogenic yeast Candida albicansBabhrubahan Roy
Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India
Mol Microbiol 80:14-32. 2011..We propose that Mis12/Mtw1 proteins also have important co-dependent interactions with inner kinetochore proteins and that these interactions may increase the fidelity of kinetochore formation...
- Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicansPilar D Cantero
Institut fur Mikrobiologie, Molekulare Mykologie, Heinrich Heine Universitat Dusseldorf, Universitätsstr 1 26 12, 40225 Dusseldorf, Germany
Mol Microbiol 80:715-25. 2011..We propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes...
- Ferric reductase genes involved in high-affinity iron uptake are differentially regulated in yeast and hyphae of Candida albicansRose E Jeeves
Department of Genetics, University of Leicester, UK
Yeast 28:629-44. 2011..This demonstrates that the regulation of two virulence determinants, the reductive iron uptake system and the morphological form of C. albicans, are linked...
- An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesisChangbin Chen
Department of Medicine, Division of Infectious Diseases, University of California San Francisco, USA
Cell Host Microbe 10:118-35. 2011..Thus, C. albicans can alternate between genetic programs conferring resistance to iron depletion in the bloodstream versus iron toxicity in the gut, and this may represent a fundamental attribute of gastrointestinal commensal-pathogens...
- Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteinsRohitashw Kumar
Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York 14214, USA
J Biol Chem 286:43748-58. 2011..Understanding of polyamine transporter-mediated internalization of Hst 5 provides new insights into the uptake mechanism for C. albicans toxicity, and further suggests design for targeted fungal therapeutic agents...
- Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesisXinde Zheng
Institute of Molecular and Cell Biology, Singapore, Singapore
EMBO J 23:1845-56. 2004..C. albicans seems to have adapted a conserved strategy to control specifically hyphal morphogenesis...
- Candida albicans Spt23p controls the expression of the Ole1p Delta9 fatty acid desaturase and regulates unsaturated fatty acid biosynthesisChan Seok Oh
Department of Cell Biology and Neuroscience, Nelson Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854 8082, USA
J Biol Chem 281:7030-9. 2006..In addition we show caSPT23 is essential for the expression of one of the two Delta9 desaturase homologues in Candida and potentially other functions associated with fatty acid metabolism...
- A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicansJill Cheetham
Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
Mol Biol Cell 18:4603-14. 2007..Collectively, our data show that Ssk2 is the sole MAPKKK to relay stress signals to Hog1 in C. albicans and that the MAPK signaling network in C. albicans has diverged significantly from the corresponding network in S. cerevisiae...
- Identification and characterization of a Jem1p ortholog of Candida albicans: dissection of Jem1p functions in karyogamy and protein quality control in Saccharomyces cerevisiaeTadashi Makio
Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
Genes Cells 13:1015-26. 2008..Since the interaction of CaJem1p with Nep98p is weaker than that of ScJem1p, the Nep98p-ScJem1p interaction is likely important for promoting karyogamy in S. cerevisiae...
- Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicansYunkyoung Song
Department of Microbiology, School of Bioscience and Biotechnology, Chungnam National University, Daejeon 305 764, Korea
Mol Biol Cell 19:5456-77. 2008..Collectively, these results demonstrate that the RAM network is critically required for hyphal growth as well as normal vegetative growth in C. albicans...
- Evolutionary tinkering with conserved components of a transcriptional regulatory networkHugo Lavoie
Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada
PLoS Biol 8:e1000329. 2010....
- A Candida albicans cell wall-linked protein promotes invasive filamentation into semi-solid mediumPaola C Zucchi
Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
Mol Microbiol 76:733-48. 2010..Some Dfi1p molecules become cross-linked to the carbohydrate polymers of the cell wall. Thus, Dfi1p is capable of linking the cell wall to the plasma membrane and cytoplasm...
- A CUG codon adapted two-hybrid system for the pathogenic fungus Candida albicansBram Stynen
Laboratory of Molecular Cell Biology, Department of Molecular Microbiology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, VIB, Kasteelpark Arenberg 31, B 3001 Leuven Heverlee, Flanders, Belgium
Nucleic Acids Res 38:e184. 2010..We conclude that this system can be used to enhance our knowledge of protein-protein interactions in C. albicans...
- Rad52 function prevents chromosome loss and truncation in Candida albicansE Andaluz
Departamento de Ciencias Biomedicas, Area Microbiologia, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain
Mol Microbiol 79:1462-82. 2011..We took advantage of the heterozygosity of HIS4 in the Candida albicans SC5314 lineage to study the role of Rad52 in the genomic stability of this important fungal pathogen...
- Sch9 kinase integrates hypoxia and CO2 sensing to suppress hyphal morphogenesis in Candida albicansCatrin Stichternoth
Institut fur Mikrobiologie, Molekulare Mykologie, Heinrich Heine Universitat Dusseldorf, Universitatsstr, Dusseldorf, Germany
Eukaryot Cell 10:502-11. 2011..albicans, which suppresses hypha formation but also allows efficient nutrient uptake, metabolism, and virulence...
- Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicansJulie Bonhomme
Institut Pasteur, Unité Biologie et Pathogénicité Fongiques, Département Génomes et Génétique, F 75015 Paris, France
Mol Microbiol 80:995-1013. 2011..Thus, adaptation to hypoxia is an integral component of biofilm formation in C. albicans...
- Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicansWataru Aoki
Japan Society for the Promotion of Science, Sakyo ku, Kyoto 606 8502, Japan
J Biochem 150:431-8. 2011..Interestingly, Sap4-6, which are coproduced in the hyphal form, were clustered as the same group, indicating that they may target similar host proteins. These results will lead to further understanding of C. albicans pathogenicity...
- Zap1 control of cell-cell signaling in Candida albicans biofilmsShantanu Ganguly
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Eukaryot Cell 10:1448-54. 2011..In addition, our results indicate that Zap1 is a positive regulator of farnesol accumulation...
- MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicansJill Cheetham
Institute for Cell and Molecular Biosciences, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
J Biol Chem 286:42002-16. 2011..This indicates that Hog1 mediates C. albicans virulence by conferring stress resistance rather than regulating morphogenesis...
- Protein phosphatase CaPpz1 is involved in cation homeostasis, cell wall integrity and virulence of Candida albicansCsaba Adám
Department of Medical Chemistry, Faculty of Medicine, Research Centre for Molecular Medicine, University of Debrecen, Debrecen, Hungary
Microbiology 158:1258-67. 2012..albicans. In addition, the germ tube growth rate, and virulence in the BALB/c mouse model, were reduced in the null mutant, suggesting a novel function for CaPpz1 in the yeast to hypha transition that may have medical relevance...
- Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic proteaseWataru Aoki
Japan Society for the Promotion of Science, Sakyo ku, Kyoto, Japan
PLoS ONE 7:e32513. 2012..Thus, it is important to elucidate their biochemical properties for better understanding of the molecular mechanisms that how Sap isozymes damage host tissues...
- The β-arrestin-like protein Rim8 is hyperphosphorylated and complexes with Rim21 and Rim101 to promote adaptation to neutral-alkaline pHJonathan Gómez-Raja
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, USA
Eukaryot Cell 11:683-93. 2012..Our analyses provide some insights into potential roles...
- The Tlo proteins are stoichiometric components of Candida albicans mediator anchored via the Med3 subunitAnda Zhang
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, USA
Eukaryot Cell 11:874-84. 2012..This study of caMediator structure provides initial clues to the mechanism of action of the Tlo genes and a platform for further mechanistic studies of caMediator's involvement in gene regulatory patterns that underlie pathogenesis...
- Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeastMichelle D Leach
Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
PLoS Pathog 8:e1003069. 2012..Therefore Hsp90 modulates the short term Hsf1-mediated activation of the classic heat shock response, coordinating this response with long term thermal adaptation via Mkc1- Hog1- and Cek1-mediated cell wall remodelling...
- Tandem affinity purification of the Candida albicans septin protein complexAki Kaneko
Department of Bioactive Molecules, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Yeast 21:1025-33. 2004..The successful application of TAP to the purification and analysis of the C. albicans septin complex indicates that this technology will have much wider application to proteomic studies of this pathogenic fungus...
- The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicansCarol A Munro
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Mol Microbiol 63:1399-413. 2007..Therefore, at least three pathways co-ordinately regulate chitin synthesis and activation of chitin synthesis operates at both transcriptional and post-transcriptional levels...
- Stimulation of chitin synthesis rescues Candida albicans from echinocandinsLouise A Walker
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
PLoS Pathog 4:e1000040. 2008..However, echinocandins and chitin synthase inhibitors synergized strongly, highlighting the potential for combination therapies with greatly enhanced cidal activity...
- Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strainsNico Dunkel
Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Wurzburg, Germany
Mol Microbiol 69:827-40. 2008..albicans...
- Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicansTithira T Wimalasena
School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Fungal Genet Biol 45:1235-47. 2008..albicans and in the expression of genes encoding cell surface proteins during ER stress, factors that are important in virulence of this fungal pathogen...
- A toolbox for epitope-tagging and genome-wide location analysis in Candida albicansHugo Lavoie
Biotechnology Research Institute, National Research Council, Montreal, Quebec, H4P 2R2, Canada
BMC Genomics 9:578. 2008..Understanding aspects of the regulation of its biological functions and the assembly of its protein complexes would lead to further insight into the biology of this common disease-causing microbial agent...
- UME6 is a crucial downstream target of other transcriptional regulators of true hyphal development in Candida albicansUte Zeidler
Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, Austria
FEMS Yeast Res 9:126-42. 2009..The expression of all hyphae-specific genes investigated depended on UME6 expression. A model for transcriptional regulation of hyphal development and the role of Ume6p is proposed...
- Efficacy of Rhodotorula glutinis and Spirulina platensis carotenoids in immunopotentiation of mice infected with Candida albicans SC5314 and Pseudomonas aeruginosa 35M M el-Sheekh
Botany Department, Faculty of Science, Tanta University, Tanta 31527, Egypt
Folia Microbiol (Praha) 55:61-7. 2010..Adding the carotenoids, phycocyanin and polysaccharides to food as additives might therefore enhance the human immune response against microbial infections...
- Antituberculosis agents and an inhibitor of the para-aminobenzoic acid biosynthetic pathway from Hydnocarpus anthelminthica seedsJun Feng Wang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P R China
Chem Biodivers 7:2046-53. 2010..3 microM, representing a new example of pAba inhibitor isolated from a natural source. All compounds were not toxic to Candida albicans SC5314 at a concentration up to 100 microM.
- Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissueShaoji Cheng
The University of Florida College of Medicine, Gainesville, FL, USA
Cell Microbiol 9:492-501. 2007After five serial passages of Candida albicans SC5314 through murine spleens by intravenous inoculation, we recovered a respiratory mutant (strain P5) that exhibited reduced colony size, stunted growth in glucose-deficient media, ..
- IL-1alpha, IL-1ra and IL-8 are differentially induced by Candida in experimental oral candidiasisJ A M S Jayatilake
Oral Bio Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong
Oral Dis 13:426-33. 2007..To investigate the expression of interleukin-1alpha (IL-1alpha), IL-1ra and IL-8 by the oral epithelium challenged by various Candida species...
- A single SNP, G929T (Gly310Val), determines the presence of a functional and a non-functional allele of HIS4 in Candida albicans SC5314: detection of the non-functional allele in laboratory strainsJonathan Gómez-Raja
Departamento de Ciencias Biomedicas, Area Microbiologia, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain
Fungal Genet Biol 45:527-41. 2008..HIS4 analysis of five commonly used laboratory strains is reported. This study provides a new, easily measured nutritional marker that can be used in future genetic studies in C. albicans...
- Proteomics of RAW 264.7 macrophages upon interaction with heat-inactivated Candida albicans cells unravel an anti-inflammatory responseLaura Martínez-Solano
Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
Proteomics 9:2995-3010. 2009Murine macrophages (RAW 264.7) were allowed to interact with heat-inactivated cells of Candida albicans SC5314 during 45 min. The proteomic response of the macrophages was then analyzed using 2-D gel electrophoresis...
- Proposal of a low-cost protocol for colorimetric semi-quantification of secretory phospholipase by Candida albicans grown in planktonic and biofilm phasesLisa Taniguchi
Laboratory of Stomatology, Faculty of Dentistry, The Pontifical Catholic University of Paraná, Rua Imaculada Conceição 1155, Curitiba, Brazil
J Microbiol Methods 78:171-4. 2009..This study evaluated the differential phospholipasic activity of Candida albicans SC5314 grown in planktonic phase and in biofilm...
- Purification and characterization of a catechol 1,2-dioxygenase from a phenol degrading Candida albicans TL3San Chin Tsai
Department of Applied Chemistry, National Chiao Tung University, 1001 Ta Hseh Rd, Hsinchu, Taiwan
Arch Microbiol 187:199-206. 2007..sequences for BLAST analysis, the outcome of the BLAST revealed that this eukaryotic 1,2-CTD has high identity with a hypothetical protein, CaO19_12036, from Candida albicans SC5314. We conclude that the hypothetical protein is 1,2-CTD.
- Influence of cigarette smoke condensate on cariogenic and candidal biofilm formation on orthodontic materialsFernanda Brasil Baboni
Graduate Program in Dentistry Orthodontics, Pontifical Catholic University of Parana, Curitiba, Parana, Brazil
Am J Orthod Dentofacial Orthop 138:427-34. 2010..analysis was made to quantify the adherence rates and the biofilm formation capacity of Streptococcus mutans ATCC25175 and Candida albicans SC5314 on orthodontic material surfaces in the presence of cigarette smoke condensate (CSC).
- Monopolin recruits condensin to organize centromere DNA and repetitive DNA sequencesLaura S Burrack
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455 Department of Molecular Microbiology and Biotechnology, George Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
Mol Biol Cell 24:2807-19. 2013..We propose that the key function of monopolin is to recruit condensin in order to promote the assembly of higher-order structure at centromere and repetitive DNA. ..
- Convergent Regulation of Candida albicans Aft2 and Czf1 in Invasive and Opaque FilamentationNing Xu
Key Laboratory of Molecular Microbiology and Technology for Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China
J Cell Biochem 116:1908-18. 2015....
- Role of the Vps34p-interacting protein Ade5,7p in hyphal growth and virulence of Candida albicansSusann Jezewski
Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Beutenbergstrasse 11, D 07745 Jena, Germany
Microbiology 153:2351-62. 2007..In summary, Ade5,7p interacts with the multifunctional virulence regulator PtdIns 3-kinase Vps34p, and ade5,7 and vps34 null mutant strains show similar phenotypes regarding sensitivity to metal ions, hyphal growth and virulence...
- Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol responseAmy E Piispanen
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
Eukaryot Cell 10:1473-84. 2011..Our findings imply that Ras1 is farnesylated and palmitoylated, and that the Ras1 stimulation of adenylate cyclase-dependent phenotypes can occur in the absence of these lipid modifications...
- A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesisNike Bharucha
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Genet 7:e1002058. 2011..albicans and support a model in which these two pathways regulate a common set of genes at different stages of filamentation...
- Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5Ori Braten
Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Efron Street, P O Box 9649, Haifa 31096, Israel
Biochem J 444:611-7. 2012..However, it appears that the stress-induced synthesis of free chains is catalyzed by a different ligase, HUL5 (HECT ubiquitin ligase 5), which is also a HECT domain E3...
- The histone acetyltransferase Hat1 facilitates DNA damage repair and morphogenesis in Candida albicansMichael Tscherner
Medical University of Vienna, Christian Doppler Laboratory for Infection Biology, Max F Perutz Laboratories, Campus Vienna Biocenter, A 1030 Vienna, Austria
Mol Microbiol 86:1197-214. 2012..Hence, we propose that targeting this class of histone acetyltransferases in fungal pathogens may have potential in antifungal therapy...
- Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicansJ B Anderson
Department of Botany, University of Toronto, Mississauga, Ontario, Canada L5L 1C6
J Bacteriol 183:865-72. 2001....
- Identification and functional characterization of a novel Candida albicans gene CaMNN5 that suppresses the iron-dependent growth defect of Saccharomyces cerevisiae aft1Delta mutantChen Bai
Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore
Biochem J 389:27-35. 2005..We propose that CaMnn5p promotes iron uptake and usage along the endocytosis pathway under iron-limiting conditions, a novel function that might have evolved in C. albicans...
- Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulenceSteven Bates
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
J Biol Chem 280:23408-15. 2005..In a murine model of systemic infection, the null mutant was severely attenuated in virulence. These results demonstrate the importance of glycosylation for cell wall structure and virulence of C. albicans...
- Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patientsChung Yeng Looi
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
FEMS Microbiol Lett 249:283-9. 2005..This finding provides new information on point mutations in the promoter region which may be responsible for the overexpression of CDR1 in drug-resistant isolates...
- New tools for phenotypic analysis in Candida albicans: the WAR1 gene confers resistance to sorbateKarine Lebel
Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
Yeast 23:249-59. 2006..albicans orf19.1035 gene results in sensitivity to the weak acid sorbate, while its overexpression increases resistance to this compound. We named it WAR1, in analogy to its S. cerevisiae orthologue...
- Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysisVersha Rai
Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
Biochemistry 45:14726-39. 2006....
- Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicansDonghak Kim
Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158 2517, USA
Biochemistry 45:14772-80. 2006..Hmx1 and CaHmx1 are the first fungal heme oxygenases to be heterologously overexpressed and characterized. Their heme degradation activity is consistent with a role in iron acquisition...
- Characterization of prostaglandin E2 production by Candida albicansJohn R Erb-Downward
Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Infect Immun 75:3498-505. 2007..This work demonstrates that the synthesis of PGE(2) in C. albicans proceeds via novel pathways...
- Promoter heterozygosity at the Candida albicans CHS7 gene is translated into differential expression between allelesMaria Sanz
Instituto de Microbiología Bioquímica y Departamento de Microbiología y Genética, CSIC Universidad de Salamanca, Salamanca, Spain
FEMS Yeast Res 7:993-1003. 2007..However, sequence comparison between strains indicated that this region is prone to genetic divergence, which is probably responsible for the reported allelic heterozygosity of CaCHS7...
- The Candida albicans gene HGT12 (orf19.7094) encodes a hexose transporterLin Luo
Institute of Molecular Biosciences, Massey University, New Zealand
FEMS Immunol Med Microbiol 51:14-7. 2007....
- Plasma-membrane Cnh1 Na+/H+ antiporter regulates potassium homeostasis in Candida albicansOlga Kinclova-Zimmermannova
Department of Membrane Transport, Institute of Physiology AS CR, v v i, Videnska 1083, 142 20 Prague 4 Krc, Czech Republic
Microbiology 153:2603-12. 2007..albicans revealed that this antiporter plays a significant role in C. albicans physiology. It ensures potassium and rubidium tolerance and participates in the regulation of intracellular potassium content of C. albicans cells...
- Switching and Candida Pathogenesis-A Molecular AnalysisDavid Soll; Fiscal Year: 2005..The first three aims have been formulated so that they provide several independent starting points for a reverse genetic approach for elucidating switch loci and the switching mechanism. ..
- Regulation of Fungal Invasive GrowthCarol Kumamoto; Fiscal Year: 2006..cerevisiae. Experiments are proposed to identify interactors that bind to the gene products of interest and to elucidate the pathways in which these gene products participate. ..
- SWITCHING IN THE ORAL COMMENSAL CANDIDA GLABRATADavid Soll; Fiscal Year: 2006..abstract_text> ..
- Regulation of Drug Resistance Genes in C. AlbicansCarol Kumamoto; Fiscal Year: 2007..The long-term goal of these studies is to contribute to a more informed use of fluconazole with respect to prophylaxis, drug dosage regimens and the development of fluconazole resistant strains. [unreadable] [unreadable] [unreadable]..
- Intestinal colonization by C.albicans and enteric bacteriaCarol Kumamoto; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
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