Helicobacter pylori 26695

Summary

Alias: Helicobacter pylori (strain 26695), Helicobacter pylori KE26695, Helicobacter pylori ATCC 700392, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695

Top Publications

  1. Bury Moné S, Skouloubris S, Labigne A, De Reuse H. The Helicobacter pylori UreI protein: role in adaptation to acidity and identification of residues essential for its activity and for acid activation. Mol Microbiol. 2001;42:1021-34 pubmed
    ..UreI behaves like a novel type of urea transporter, and the identification of residues essential for its function in H. pylori provides new insight into the unusual molecular mechanism of low pH activation. ..
  2. Skouloubris S, Thiberge J, Labigne A, De Reuse H. The Helicobacter pylori UreI protein is not involved in urease activity but is essential for bacterial survival in vivo. Infect Immun. 1998;66:4517-21 pubmed
    ..2) in the presence of 10 mM urea. UreI is predicted to be an integral membrane protein and may therefore be involved in a transport process essential for H. pylori survival in vivo. ..
  3. Kang J, Blaser M. UvrD helicase suppresses recombination and DNA damage-induced deletions. J Bacteriol. 2006;188:5450-9 pubmed
    ..pylori that face high-level genotoxic stress in vivo. ..
  4. Bereswill S, Lichte F, Vey T, Fassbinder F, Kist M. Cloning and characterization of the fur gene from Helicobacter pylori. FEMS Microbiol Lett. 1998;159:193-200 pubmed
    ..pylori strain NCTC11638 with the recently published genomic DNA sequence of another strain (26695) confirmed the identity of the fur homologue and revealed that the fur locus is highly conserved in both strains. ..
  5. Namavar F, Sparrius M, Veerman E, Appelmelk B, Vandenbroucke Grauls C. Neutrophil-activating protein mediates adhesion of Helicobacter pylori to sulfated carbohydrates on high-molecular-weight salivary mucin. Infect Immun. 1998;66:444-7 pubmed
    ..Sequence analysis of the protein proved that it was identical to the N-terminal amino acid sequence of neutrophil-activating protein. Moreover, this adhesin was able to bind to Lewis x blood group antigen. ..
  6. Ilver D, Arnqvist A, Ogren J, Frick I, Kersulyte D, Incecik E, et al. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science. 1998;279:373-7 pubmed
    ..pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori. ..
  7. Han K, Park S, Jang S, Son W, Lee B. Solution structure of conserved hypothetical protein HP0894 from Helicobacter pylori. Proteins. 2005;61:1114-6 pubmed
  8. Skouloubris S, Labigne A, De Reuse H. The AmiE aliphatic amidase and AmiF formamidase of Helicobacter pylori: natural evolution of two enzyme paralogues. Mol Microbiol. 2001;40:596-609 pubmed
    ..pylori paralogous amidases have evolved to achieve enzymatic specialization after ancestral gene duplication; and (ii) the production of these enzymes is regulated to maintain intracellular nitrogen balance in H. pylori. ..
  9. Zhou Y, Coleman W, Yang Z, Yang Y, Hodgson N, Chen F, et al. Regulation of cell growth during serum starvation and bacterial survival in macrophages by the bifunctional enzyme SpoT in Helicobacter pylori. J Bacteriol. 2008;190:8025-32 pubmed publisher
    ..The unique role of (p)ppGpp in cell growth during serum starvation, in the stress response, and in the persistence of H. pylori is discussed. ..

More Information

Publications90

  1. Phadnis S, Ilver D, Janzon L, Normark S, Westblom T. Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect Immun. 1994;62:1557-65 pubmed
    ..We further show that in at least one cytotoxin-negative but vacA-positive strain (MO19), there are variations in the length of the vacA gene that could explain the cytotoxin-negative phenotype in this strain. ..
  2. Falush D, Kraft C, Taylor N, Correa P, Fox J, Achtman M, et al. Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal age. Proc Natl Acad Sci U S A. 2001;98:15056-61 pubmed
    ..Thus, the panmictic population structure of H. pylori results from very frequent recombination during mixed colonization by unrelated strains. ..
  3. Suganuma M, Kurusu M, Suzuki K, Nishizono A, Murakami K, Fujioka T, et al. New tumor necrosis factor-alpha-inducing protein released from Helicobacter pylori for gastric cancer progression. J Cancer Res Clin Oncol. 2005;131:305-13 pubmed
    ..Tipalpha is a new carcinogenic factor released from H. pylori mediated through NF-kappaB activation. ..
  4. Evans D, Evans D, Lampert H, Nakano H. Identification of four new prokaryotic bacterioferritins, from Helicobacter pylori, Anabaena variabilis, Bacillus subtilis and Treponema pallidum, by analysis of gene sequences. Gene. 1995;153:123-7 pubmed
    ..Genes Dev. 6 (1992) 2646-2654] is clearly a HPNAP/Bfr homologue, a significant part of its Frx center is missing. It is unlikely that the intracellular function of HPNAP is related to its ability to activate neutrophils. ..
  5. Blomstergren A, Lundin A, Nilsson C, Engstrand L, Lundeberg J. Comparative analysis of the complete cag pathogenicity island sequence in four Helicobacter pylori isolates. Gene. 2004;328:85-93 pubmed
    ..Finally, a novel gene was identified in the cag PAI in three of the sequenced strains at the position of HP0521. This gene, HP0521B, is present in approximately half of Swedish H. pylori isolates. ..
  6. Mao Y, Yan J. Construction of prokaryotic expression system of ureB gene from a clinical Helicobacter pylori strain and identification of the recombinant protein immunity. World J Gastroenterol. 2004;10:977-84 pubmed
    ..High frequencies of UreB expression in different H pylori isolates and specific antibody against UreB in sera of H pylori infected patients indicate that UreB is an excellent antigen candidate for developing H pylori vaccine. ..
  7. Marsin S, Mathieu A, Kortulewski T, Guerois R, Radicella J. Unveiling novel RecO distant orthologues involved in homologous recombination. PLoS Genet. 2008;4:e1000146 pubmed publisher
    ..These results provide insight into the mechanisms that this successful pathogen uses to generate genetic diversity and adapt to changing environments and new hosts. ..
  8. Jang J, Yoon H, Yoon J, Kim H, Lee S, Kim K, et al. Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activity. J Mol Biol. 2009;392:191-7 pubmed publisher
    ..A positively charged surface patch formed across the two monomers of the Tipalpha dimer by the loop between helices alpha1 and alpha2 may be important in DNA binding. ..
  9. O Rourke E, Chevalier C, Boiteux S, Labigne A, Ielpi L, Radicella J. A novel 3-methyladenine DNA glycosylase from Helicobacter pylori defines a new class within the endonuclease III family of base excision repair glycosylases. J Biol Chem. 2000;275:20077-83 pubmed
    ..MagIII is thus a novel bacterial member of the endonuclease III family, which displays biochemical properties not described for any of the members of this group until now. ..
  10. Dunn B, Campbell G, Perez Perez G, Blaser M. Purification and characterization of urease from Helicobacter pylori. J Biol Chem. 1990;265:9464-9 pubmed
    ..pylori proteins at distinguishing sera from persons known either to be infected with H. pylori or not. ..
  11. Tonello F, Dundon W, Satin B, Molinari M, Tognon G, Grandi G, et al. The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure. Mol Microbiol. 1999;34:238-46 pubmed
    ..We therefore conclude that HP-NAP is an unusual, small, ferritin that folds into a four-helix bundle that oligomerizes into dodecamers with a central hole capable of binding up to 500 iron atoms per oligomer. ..
  12. O Rourke E, Pinto A, Petroni E, Tolmasky M, Ielpi L. Evidence for the active role of a novel nuclease from Helicobacter pylori in the horizontal transfer of genetic information. J Bacteriol. 2004;186:2586-93 pubmed
  13. Thompson S, Blaser M. Isolation of the Helicobacter pylori recA gene and involvement of the recA region in resistance to low pH. Infect Immun. 1995;63:2185-93 pubmed
    ..This difference occurred in the presence or absence of urea, implying the involvement of a gene in the recA region in an acid resistance mechanism distinct from that mediated by urease. ..
  14. Tsuda M, Karita M, Morshed M, Okita K, Nakazawa T. A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach. Infect Immun. 1994;62:3586-9 pubmed
    ..There was no gastritis in the HPT73-challenged stomachs, and we could not recover H. pylori from them. These results indicated that H. pylori urease is essential for colonizing the nude mouse stomach. ..
  15. Schmitt W, Haas R. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol Microbiol. 1994;12:307-19 pubmed
  16. Loh J, Cover T. Requirement of histidine kinases HP0165 and HP1364 for acid resistance in Helicobacter pylori. Infect Immun. 2006;74:3052-9 pubmed
    ..These results indicate that intact HP0165 and HP1364 histidine kinases are required for acid resistance in H. pylori. ..
  17. Akada J, Shirai M, Takeuchi H, Tsuda M, Nakazawa T. Identification of the urease operon in Helicobacter pylori and its control by mRNA decay in response to pH. Mol Microbiol. 2000;36:1071-84 pubmed
    ..We are tempted to speculate that the ureE" transcript present in acidic pH may contribute to produce an active product that can proceed the nickel incorporation to the active centre, the final step of urease biosynthesis. ..
  18. Cao P, Cover T. High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori. J Bacteriol. 1997;179:2852-6 pubmed
    ..5-kb DNA segments, which were both unrelated to vapD. The presence of vapD was not associated with any specific family of vacA alleles. These findings are consistent with a recombinational population structure for H. pylori. ..
  19. Akopyants N, Clifton S, Kersulyte D, Crabtree J, Youree B, Reece C, et al. Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol. 1998;28:37-53 pubmed
    ..Our results are discussed in terms of how cag-encoded proteins might help trigger the damaging inflammatory responses in the gastric epithelium and possible contributions of DNA rearrangements to genome evolution. ..
  20. Evans D, Evans D, Takemura T, Nakano H, Lampert H, Graham D, et al. Characterization of a Helicobacter pylori neutrophil-activating protein. Infect Immun. 1995;63:2213-20 pubmed
    ..pylori isolates tested; however, there was considerable strain variation in the level of expression of HP-NAP activity in vitro. HP-NAP could play an important role in the gastric inflammatory response to H. pylori infection. ..
  21. Rain J, Selig L, De Reuse H, Battaglia V, Reverdy C, Simon S, et al. The protein-protein interaction map of Helicobacter pylori. Nature. 2001;409:211-5 pubmed
    ..6% of the proteome. The determination of a reliability score for every single protein-protein interaction and the identification of the actual interacting domains permitted the assignment of unannotated proteins to biological pathways. ..
  22. Pinto A, Mathieu A, Marsin S, Veaute X, Ielpi L, Labigne A, et al. Suppression of homologous and homeologous recombination by the bacterial MutS2 protein. Mol Cell. 2005;17:113-20 pubmed
    ..Finally, we show that HpMutS2 inhibits DNA strand exchange reactions in vitro. Thus, MutS2 proteins are candidates for controlling recombination and therefore genetic diversity in bacteria. ..
  23. Cover T, Tummuru M, Cao P, Thompson S, Blaser M. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem. 1994;269:10566-73 pubmed
    ..8% amino acid identity with the corresponding region from tox+ strain 60190. Thus, sequence divergence in vacA genes may explain the lack of functionally active cytotoxin production by some H. pylori isolates. ..
  24. Ishiyama N, Creuzenet C, Miller W, Demendi M, Anderson E, Harauz G, et al. Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity. J Biol Chem. 2006;281:24489-95 pubmed
    ..Guided by evidence from site-directed mutagenesis and computational simulations, a three-step reaction mechanism is proposed that involves Lys-133 functioning as both a catalytic acid and base. ..
  25. Marsin S, Lopes A, Mathieu A, Dizet E, Orillard E, Guerois R, et al. Genetic dissection of Helicobacter pylori AddAB role in homologous recombination. FEMS Microbiol Lett. 2010;311:44-50 pubmed publisher
    ..However, neither of these complexes participates in the RecA-dependent process of transformation of these naturally competent bacteria. ..
  26. Tsuge H, Tsurumura T, Utsunomiya H, Kise D, Kuzuhara T, Watanabe T, et al. Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein. Biochem Biophys Res Commun. 2009;388:193-8 pubmed publisher
    ..del-Tipalpha's unique mode of dimer formation provides important insight into protein-protein interactions and into the mechanism underlying the carcinogenicity of H. pylori infection. ..
  27. Luthy L, Grutter M, Mittl P. The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein. J Biol Chem. 2002;277:10187-93 pubmed
    ..The putative penicillin binding site is located in an amphipathic groove on the concave side of the molecule. ..
  28. Phadnis S, Parlow M, Levy M, Ilver D, Caulkins C, Connors J, et al. Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysis. Infect Immun. 1996;64:905-12 pubmed
    ..pylori is an important phenomenon to recognize since it likely exerts significant effects on the behavior of H. pylori. Furthermore, the surface properties of H. pylori must be unique in promoting adsorption of cytoplasmic proteins. ..
  29. Ernst F, Homuth G, Stoof J, Mäder U, Waidner B, Kuipers E, et al. Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by Fur. J Bacteriol. 2005;187:3687-92 pubmed
    ..In conclusion, H. pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization, including superoxide stress defense. ..
  30. Tummuru M, Sharma S, Blaser M. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol. 1995;18:867-76 pubmed
  31. Olson J, Mehta N, Maier R. Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pylori. Mol Microbiol. 2001;39:176-82 pubmed
  32. Teneberg S, Miller Podraza H, Lampert H, Evans D, Evans D, Danielsson D, et al. Carbohydrate binding specificity of the neutrophil-activating protein of Helicobacter pylori. J Biol Chem. 1997;272:19067-71 pubmed
    ..pylori preferentially recognizes glycoconjugates with a terminally unsubstituted NeuAcalpha3Galbeta4GlcNAcbeta3Galbeta4GlcNAcbeta sequence. ..
  33. Wen Y, Feng J, Scott D, Marcus E, Sachs G. The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori. J Bacteriol. 2009;191:449-60 pubmed publisher
  34. Mathieu A, O Rourke E, Radicella J. Helicobacter pylori genes involved in avoidance of mutations induced by 8-oxoguanine. J Bacteriol. 2006;188:7464-9 pubmed
    ..pylori cell extracts. Disruption of HP1526, a putative xth homolog, confirmed that this gene is responsible for the AP endonuclease activity. The lack of evidence for an Fpg/OGG1 functional homolog is also discussed. ..
  35. Azuma T, Yamakawa A, Yamazaki S, Ohtani M, Ito Y, Muramatsu A, et al. Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in Japan. J Clin Microbiol. 2004;42:2508-17 pubmed
    ..These results suggest that a distinct diversity of the cag PAI of H. pylori is present among Japanese strains and that this diversity may be involved in the development of atrophic gastritis and may increase the risk for gastric cancer. ..
  36. van Vliet A, Kuipers E, Waidner B, Davies B, de Vries N, Penn C, et al. Nickel-responsive induction of urease expression in Helicobacter pylori is mediated at the transcriptional level. Infect Immun. 2001;69:4891-7 pubmed
    ..These data demonstrate nickel-responsive regulation of H. pylori urease, a phenomenon likely to be of importance during the colonization and persistence of H. pylori in the gastric mucosa. ..
  37. Weeks D, Eskandari S, Scott D, Sachs G. A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Science. 2000;287:482-5 pubmed
    ..UreI functions as a H+-gated urea channel regulating cytoplasmic urease that is essential for gastric survival and colonization. ..
  38. Schmitt W, Odenbreit S, Heuermann D, Haas R. Cloning of the Helicobacter pylori recA gene and functional characterization of its product. Mol Gen Genet. 1995;248:563-72 pubmed
    ..pylori which is crucial for its function. The potential modification seems not to occur when the protein is produced in E. coli, giving rise to a smaller but inactive protein. ..
  39. Spiegelhalder C, Gerstenecker B, Kersten A, Schiltz E, Kist M. Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene. Infect Immun. 1993;61:5315-25 pubmed
    ..There was no leader sequence detectable. Cloning of the H. pylori SOD gene is one of the prerequisites to investigation of its pathophysiological role in the defense against antimicrobial mechanisms of polymorphonuclear granulocytes. ..
  40. Goodwin A, Kersulyte D, Sisson G, Veldhuyzen van Zanten S, Berg D, Hoffman P. Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase. Mol Microbiol. 1998;28:383-93 pubmed
  41. Owen R, Xerry J. Tracing clonality of Helicobacter pylori infecting family members from analysis of DNA sequences of three housekeeping genes (ureI, atpA and ahpC), deduced amino acid sequences, and pathogenicity-associated markers (cagA and vacA). J Med Microbiol. 2003;52:515-24 pubmed
    ..Analysis of these three housekeeping genes provides unique evidence for precise tracing of clonal descent in isolates of H. pylori in family groups. ..
  42. van Vliet A, Stoof J, Poppelaars S, Bereswill S, Homuth G, Kist M, et al. Differential regulation of amidase- and formamidase-mediated ammonia production by the Helicobacter pylori fur repressor. J Biol Chem. 2003;278:9052-7 pubmed
    ..These roles of Fur in regulation of the H. pylori amidases suggest that the H. pylori Fur regulator may have acquired extra functions to compensate for the absence of other regulatory systems. ..
  43. Wang W, Ding J, Zhang Y, Hu Y, Wang D. Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA. Nucleic Acids Res. 2014;42:3478-91 pubmed publisher
  44. Lee M, Huang C, Sun Y, Huang H. Cloning and characterization of spermidine synthase and its implication in polyamine biosynthesis in Helicobacter pylori strain 26695. Protein Expr Purif. 2005;43:140-8 pubmed publisher
    The HP0832 (speE) gene of Helicobacter pylori strain 26695 codes for a putative spermidine synthase, which belongs to the polyamine biosynthetic pathway...
  45. McGee D, May C, Garner R, Himpsl J, Mobley H. Isolation of Helicobacter pylori genes that modulate urease activity. J Bacteriol. 1999;181:2477-84 pubmed
    ..Thus, flagellar biosynthesis and urease activity may be linked in H. pylori. These results suggest that H. pylori genes may modulate urease activity...
  46. Kumar R, Mukhopadhyay A, Rao D. Characterization of an N6 adenine methyltransferase from Helicobacter pylori strain 26695 which methylates adjacent adenines on the same strand. FEBS J. 2010;277:1666-83 pubmed publisher
    ..pylori. Collectively, these findings provide impetus for exploring the role(s) of this conserved DNA methyltransferase in the cellular processes of H. pylori...
  47. Yu C, Wang C, Chew Y, Wang P, Yin H, Kao M. Functional characterization of Helicobacter pylori 26695 sedoheptulose 7-phosphate isomerase encoded by hp0857 and its association with lipopolysaccharide biosynthesis and adhesion. Biochem Biophys Res Commun. 2016;477:794-800 pubmed publisher
    ..In conclusion, we demonstrated that HP0857 protein is essential for inner core biosynthesis of H. pylori LPS and is a potential target for developing new antimicrobial agents against H. pylori infection. ..
  48. Ding H, Zeng H, Huang L, Dong Y, Duan Y, Mao X, et al. Helicobacter pylori chaperone-like protein CagT plays an essential role in the translocation of CagA into host cells. J Microbiol Biotechnol. 2012;22:1343-9 pubmed
    ..These results suggest that CagT is expressed on both the inner and outer bacterial membranes, where it serves as a unique type IV secretion system component that is involved in CagA secretion and cag PAI apparatus assembly...
  49. Nishikawa H, Hayashi T, Arisaka F, Senda T, Hatakeyama M. Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b. Sci Rep. 2016;6:30031 pubmed publisher
    ..pylori infection, including gastric cancer. ..
  50. Sim D, Lee Y, Kim J, Seo M, Lee B, Won H. HP0902 from Helicobacter pylori is a thermostable, dimeric protein belonging to an all-beta topology of the cupin superfamily. BMB Rep. 2009;42:387-92 pubmed
    ..The results revealed that HP0902 would adopt a compactly folded, all-beta topology with 11 beta-strands. All of the results clearly support the notion that HP0902 belongs to the cupin superfamily of proteins. ..
  51. Vitale S, Fauquant C, Lascoux D, Schauer K, Saint Pierre C, Michaud Soret I. A ZnS(4) structural zinc site in the Helicobacter pylori ferric uptake regulator. Biochemistry. 2009;48:5582-91 pubmed publisher
    ..Furthermore, the redox state of the cysteines and the zinc binding are essential to hold the H. pylori Fur in a dimeric state...
  52. Wang G, Maier R. A RecB-like helicase in Helicobacter pylori is important for DNA repair and host colonization. Infect Immun. 2009;77:286-91 pubmed publisher
    ..In a mouse infection model, the HP1553 mutant strain displayed a greatly reduced ability to colonize the host stomachs, indicating that HP1553 plays a significant role in H. pylori survival/colonization in the host...
  53. Godlewska R, Bujnicki J, Ostrowski J, Jagusztyn Krynicka E. The hppA gene of Helicobacter pylori encodes the class C acid phosphatase precursor. FEBS Lett. 2002;525:39-42 pubmed
  54. Lee B, Suh S. Crystal structure of the schiff base intermediate prior to decarboxylation in the catalytic cycle of aspartate alpha-decarboxylase. J Mol Biol. 2004;340:1-7 pubmed publisher
    ..Thus our study provides direct structural evidence for the reaction mechanism of ADC...
  55. Tsugawa H, Mori H, Matsuzaki J, Masaoka T, Hirayama T, Nagasawa H, et al. Nordihydroguaiaretic Acid Disrupts the Antioxidant Ability of Helicobacter pylori through the Repression of SodB Activity In Vitro. Biomed Res Int. 2015;2015:734548 pubmed publisher
  56. Tavares R, Pathak S. Helicobacter pylori Secreted Protein HP1286 Triggers Apoptosis in Macrophages via TNF-Independent and ERK MAPK-Dependent Pathways. Front Cell Infect Microbiol. 2017;7:58 pubmed publisher
    ..pylori infection. Considering the ability of HP1286 to induce macrophage apoptosis, the protein could possibly help in the bacterial escape from the activated macrophages and persistence in the stomach. ..
  57. Morrow A, Williams K, Sand A, Boanca G, Barycki J. Characterization of Helicobacter pylori gamma-glutamyltranspeptidase reveals the molecular basis for substrate specificity and a critical role for the tyrosine 433-containing loop in catalysis. Biochemistry. 2007;46:13407-14 pubmed publisher
  58. Suerbaum S, Kraft C, Dewhirst F, Fox J. Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pylori. Int J Syst Evol Microbiol. 2002;52:437-9 pubmed publisher
    ..nemestrinae ATCC 49396T is really a strain of H. pylori and that H. nemestrinae Bronsdon et al. 1991 is a junior heterotypic synonym of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989...
  59. Brand L, Strauss E. Characterization of a new pantothenate kinase isoform from Helicobacter pylori. J Biol Chem. 2005;280:20185-8 pubmed publisher
    ..Taken together, these results point to the identification of a third distinct isoform of PanK that accounts for the only known activity of the enzyme in pathogens such as H. pylori and P. aeruginosa...
  60. Boanca G, Sand A, Okada T, Suzuki H, Kumagai H, Fukuyama K, et al. Autoprocessing of Helicobacter pylori gamma-glutamyltranspeptidase leads to the formation of a threonine-threonine catalytic dyad. J Biol Chem. 2007;282:534-41 pubmed publisher
    ..Substrate docking studies in combination with homology modeling studies of the human homologue reveal additional mechanistic details of enzyme maturation and activation, substrate recognition, and catalysis...
  61. Paul R, Postius S, Melchers K, Sch fer K. Mutations of the Helicobacter pylori genes rdxA and pbp1 cause resistance against metronidazole and amoxicillin. Antimicrob Agents Chemother. 2001;45:962-5 pubmed publisher
    ..pylori...
  62. Altman E, Chandan V, Larocque S, Aubry A, Logan S, Vinogradov E, et al. Effect of the HP0159 ORF mutation on the lipopolysaccharide structure and colonizing ability of Helicobacter pylori. FEMS Immunol Med Microbiol. 2008;53:204-13 pubmed publisher
    ..Colonization studies with HP0159 mutants of two mouse-colonizing strains, SS1 and M6, confirmed their inability to successfully colonize the murine stomach...
  63. Chaput C, Ecobichon C, Cayet N, Girardin S, Werts C, Guadagnini S, et al. Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape. PLoS Pathog. 2006;2:e97 pubmed publisher
    ..pylori infection...
  64. Scott D, Marcus E, Wen Y, Singh S, Feng J, Sachs G. Cytoplasmic histidine kinase (HP0244)-regulated assembly of urease with UreI, a channel for urea and its metabolites, CO2, NH3, and NH4(+), is necessary for acid survival of Helicobacter pylori. J Bacteriol. 2010;192:94-103 pubmed publisher
    ..Assembly of a pH-regulatory complex of active urease with UreI provides an advantage for periplasmic buffering...
  65. Kwon D, Dore M, Kim J, Kato M, Lee M, Wu J, et al. High-level beta-lactam resistance associated with acquired multidrug resistance in Helicobacter pylori. Antimicrob Agents Chemother. 2003;47:2169-78 pubmed
    ..pylori is mediated by combination strategies including alterations of PBP 1A and decreased membrane permeability...
  66. Stead C, Zhao J, Raetz C, Trent M. Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface. Mol Microbiol. 2010;78:837-52 pubmed publisher
    ..Taken together, we have demonstrated that loss of Kdo hydrolase activity affects all three domains of H. pylori LPS, thus highlighting its role in the maintenance of the bacterial surface...
  67. Thibonnier M, Thiberge J, De Reuse H. Trans-translation in Helicobacter pylori: essentiality of ribosome rescue and requirement of protein tagging for stress resistance and competence. PLoS ONE. 2008;3:e3810 pubmed publisher
    ..Finally, the essential trans-translation machinery of H. pylori is an excellent specific target for the development of novel antibiotics...
  68. Tran A, Karbarz M, Wang X, Raetz C, McGrath S, Cotter R, et al. Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. J Biol Chem. 2004;279:55780-91 pubmed
    ..pylori lipid A. In summary, we demonstrate that modification of the 1-phosphate group of H. pylori lipid A requires two enzymatic steps...
  69. Davis G, Mobley H. Contribution of dppA to urease activity in Helicobacter pylori 26695. Helicobacter. 2005;10:416-23 pubmed
    ..The predicted Dpp polypeptides DppA, DppC, and DppD of H. pylori share approximately 40%, 53%, and 56% amino acid sequence identity with their respective E. coli homologs...
  70. Valvano M, Messner P, Kosma P. Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides. Microbiology. 2002;148:1979-89 pubmed publisher
  71. Choi Y, Kim J, Park B, Kim B. Solubilization and Iterative Saturation Mutagenesis of α1,3-fucosyltransferase from Helicobacter pylori to enhance its catalytic efficiency. Biotechnol Bioeng. 2016;113:1666-75 pubmed publisher
    ..1,3-FucT from Helicobacter pylori 26695 (FutA) accepts lactose and LacNAc as glycan acceptors and has a very low level of expression in ..
  72. Covacci A, Rappuoli R. Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell. J Exp Med. 2000;191:587-92 pubmed
  73. Sim D, Kim J, Kim H, Jang J, Lee W, Kim E, et al. Structural identification of the lipopolysaccharide-binding capability of a cupin-family protein from Helicobacter pylori. FEBS Lett. 2016;590:2997-3004 pubmed publisher
    ..pylori. Furthermore, identification of the ability of HP0902 to bind LPS uncovers a putative role for this protein in H. pylori pathogenicity. ..
  74. Hendricks J, Mobley H. Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity. J Bacteriol. 1997;179:5892-902 pubmed
    ..0001]). Synthesis of urease apoenzyme, however, was unaffected by mutations in any of the abc genes. We conclude that the abc gene cluster, in addition to nixA, is involved in production of a catalytically active urease...
  75. Linpisarn S, Suwan W, Lertprasertsuk N, Koosirirat C, Steger H, Prommuangyong K, et al. Helicobacter pylori cagA, vacA and iceA genotypes in northern Thai patients with gastric disease. Southeast Asian J Trop Med Public Health. 2007;38:356-62 pubmed
    ..cagA positive and mixed vacA s1a and s1c strains were found in significantly more cases of duodenal ulcer than gastritis (p < 0.05). For iceA, subtype iceA1 reached a frequency of 60%, whereas subtype iceA2 was only 24%...
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    ..1.7 subgroup of the Major Facilitator Superfamily, constituting the route for entry of sugar nutrients into H. pylori. A model is derived of its three-dimensional structure as a paradigm of the family. ..
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    ..Furthermore, inactivation of iceA did not affect the apoptotic cell death of SGC7901. Our findings indicate that iceA may contribute to the pathogenicity of H. pylori by modulating the production of IL-8 by host epithelial cells...
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    ..We also showed that the amino-terminal domain of HU is relevant to DNA-protein complex formation and that the flexible arm of HU is involved in the bending and compaction activities of HU. ..
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    ..pylori may have evolved a spacer region of the sigma factor to modulate total transcription and to quickly respond to microenvironmental changes...
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    ..pylori. ..
  81. Guo L, Zhang J, Cui L, Liu D, Ma B, Wang S, et al. Crystallization and X-ray analysis of the extracellular adhesion domain of Helicobacter pylori adhesin A: the significance of the cation composition in the crystallization precipitant. Acta Crystallogr F Struct Biol Commun. 2017;73:202-208 pubmed publisher
    ..01, b = 190.56, c = 106.31?Å. The collection of diffraction data has established a solid basis for structure determination. ..