Chlamydia trachomatis D/UW-3/CX

Summary

Alias: Chlamydia trachomatis str. D/UW-3/CX, Chlamydia trachomatis strain D/UW-3/CX

Top Publications

  1. Fahr M, Douglas A, Xia W, Hatch T. Characterization of late gene promoters of Chlamydia trachomatis. J Bacteriol. 1995;177:4252-60 pubmed
    ..These results suggest that the transcription of at least some chlamydial late-stage genes is dependent on sigma 66, which is homologous to the major sigma factors of other eubacteria. ..
  2. Hackstadt T, Scidmore Carlson M, Shaw E, Fischer E. The Chlamydia trachomatis IncA protein is required for homotypic vesicle fusion. Cell Microbiol. 1999;1:119-30 pubmed
    ..trachomatis, but not C. psittaci, IncA interactions. Despite the inhibition of homotypic fusion of C. trachomatis inclusions, fusion of sphingomyelin-containing vesicles with the inclusion was not suppressed. ..
  3. Fields K, Mead D, Dooley C, Hackstadt T. Chlamydia trachomatis type III secretion: evidence for a functional apparatus during early-cycle development. Mol Microbiol. 2003;48:671-83 pubmed
    ..Mid-cycle expression of type III genes would then replenish secretion apparatus on vegetative RBs and serve as a source of secretion pores for subsequently formed EBs. ..
  4. Thalmann J, Janik K, May M, Sommer K, Ebeling J, Hofmann F, et al. Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. PLoS ONE. 2010;5:e9887 pubmed publisher
    ..Our data strongly suggest CT166's participation as an effector protein during host-cell entry, ensuring a balanced uptake into host-cells by interfering with Rac-dependent cytoskeletal changes. ..
  5. Hackstadt T, Baehr W, Ying Y. Chlamydia trachomatis developmentally regulated protein is homologous to eukaryotic histone H1. Proc Natl Acad Sci U S A. 1991;88:3937-41 pubmed
  6. Stothard D, Toth G, Batteiger B. Polymorphic membrane protein H has evolved in parallel with the three disease-causing groups of Chlamydia trachomatis. Infect Immun. 2003;71:1200-8 pubmed
    ..PmpE showed a high degree of diversity in the ocular strains compared to the other strains. Finally, the evolution of PmpH shows three groups that reflect disease groups, suggesting this protein may play a role in pathogenesis. ..
  7. Gomes J, Bruno W, Borrego M, Dean D. Recombination in the genome of Chlamydia trachomatis involving the polymorphic membrane protein C gene relative to ompA and evidence for horizontal gene transfer. J Bacteriol. 2004;186:4295-306 pubmed
  8. Gomes J, Bruno W, Nunes A, Santos N, Florindo C, Borrego M, et al. Evolution of Chlamydia trachomatis diversity occurs by widespread interstrain recombination involving hotspots. Genome Res. 2007;17:50-60 pubmed
  9. Lad S, Li J, da Silva Correia J, Pan Q, Gadwal S, Ulevitch R, et al. Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia. Proc Natl Acad Sci U S A. 2007;104:2933-8 pubmed
    ..The data presented here demonstrate that chlamydiae have the ability to convert a regulatory molecule of host inflammatory response to a dominant negative inhibitor of the same pathway potentially to minimize inflammation. ..

More Information

Publications102 found, 100 shown here

  1. Hower S, Wolf K, Fields K. Evidence that CT694 is a novel Chlamydia trachomatis T3S substrate capable of functioning during invasion or early cycle development. Mol Microbiol. 2009;72:1423-37 pubmed publisher
    ..These data indicate that CT694 is a novel T3S-dependent substrate unique to C. trachomatis, and that its interaction with host proteins such as AHNAK may be important for aspects of invasion or development particular to this species. ..
  2. Lad S, Yang G, Scott D, Wang G, Nair P, Mathison J, et al. Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response. J Bacteriol. 2007;189:6619-25 pubmed
    ..Together, the study demonstrates that CT441 is a tail-specific protease that is capable of interfering with the NF-kappaB pathway of host antimicrobial and inflammatory responses. ..
  3. Koo I, Walthers D, Hefty P, Kenney L, Stephens R. ChxR is a transcriptional activator in Chlamydia. Proc Natl Acad Sci U S A. 2006;103:750-5 pubmed
    ..Both proteins could bind simultaneously to their nonoverlapping binding sites. This report identifies a stage-specific transcriptional regulator and some of its target genes in Chlamydia...
  4. Brinkworth A, Malcolm D, Pedrosa A, Roguska K, Shahbazian S, Graham J, et al. Chlamydia trachomatis Slc1 is a type III secretion chaperone that enhances the translocation of its invasion effector substrate TARP. Mol Microbiol. 2011;82:131-44 pubmed publisher
    ..Also, coexpression of Slc1 specifically enhanced host cell translocation of TARP by a heterologous Yersinia enterocolitica T3SS. Taken together, we propose Slc1 as a chaperone of the C. trachomatis T3SS effector TARP...
  5. Gloeckl S, Ong V, Patel P, Tyndall J, Timms P, Beagley K, et al. Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis. Mol Microbiol. 2013;89:676-89 pubmed publisher
  6. Jiang W, Hoffart L, Krebs C, Bollinger J. A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase. Biochemistry. 2007;46:8709-16 pubmed publisher
  7. Akers J, Hodac H, Lathrop R, Tan M. Identification and functional analysis of CT069 as a novel transcriptional regulator in Chlamydia. J Bacteriol. 2011;193:6123-31 pubmed publisher
    ..These results provide evidence that CT069 is a negative regulator of the ytg operon, which encodes a putative metal ion transporter in C. trachomatis. ..
  8. Hackstadt T, Brickman T, Barry C, Sager J. Diversity in the Chlamydia trachomatis histone homologue Hc2. Gene. 1993;132:137-41 pubmed
    ..psittaci. The variation in Hc2 size among C. trachomatis serovars was found to be due to internal deletions from a region of the hctB gene encoding lysine- and alanine-rich pentameric repeats...
  9. Halse T, Musser K, Limberger R. A multiplexed real-time PCR assay for rapid detection of Chlamydia trachomatis and identification of serovar L-2, the major cause of Lymphogranuloma venereum in New York. Mol Cell Probes. 2006;20:290-7 pubmed publisher
    ..This assay represents the first real-time PCR method capable of detecting C. trachomatis DNA, and of simultaneously identifying C. trachomatis infection as serovar L-2...
  10. Ong V, Marsh J, Lawrence A, Allan J, Timms P, Huston W. The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence. Front Cell Infect Microbiol. 2013;3:100 pubmed publisher
    ..Thus, CtHtrA is an essential protease with both replicative phase and stress condition functions for Chlamydia trachomatis. ..
  11. Yao J, Abdelrahman Y, Robertson R, Cox J, Belland R, White S, et al. Type II fatty acid synthesis is essential for the replication of Chlamydia trachomatis. J Biol Chem. 2014;289:22365-76 pubmed publisher
    ..These results demonstrate that FASII activity is essential for C. trachomatis proliferation within its eukaryotic host and validate CtFabI as a therapeutic target against C. trachomatis. ..
  12. Hackstadt T. Purification and N-terminal amino acid sequences of Chlamydia trachomatis histone analogs. J Bacteriol. 1991;173:7046-9 pubmed
    ..The N terminus of the variable histone was conserved among C. trachomatis serotypes L2, D, and B and was distinct from that of Hc1. ..
  13. Jia T, Liu D, Luo J, Zhong G. [Localization of the hypothetical protein CT249 in the Chlamydia trachomatis inclusion membrane]. Wei Sheng Wu Xue Bao. 2007;47:645-8 pubmed
    ..Given the potentially important role of inclusion membrane proteins in chlamydial interactions with host cells, this finding has provided a useful tool for further understanding the mechanisms of chlamydial intracellular parasitism. ..
  14. Gong S, Lei L, Chang X, Belland R, Zhong G. Chlamydia trachomatis secretion of hypothetical protein CT622 into host cell cytoplasm via a secretion pathway that can be inhibited by the type III secretion system inhibitor compound 1. Microbiology. 2011;157:1134-44 pubmed publisher
    ..These results suggest that CT621 and CT622 may fulfil different functions during chlamydial intracellular growth. Further characterization of these proteins may generate important information for understanding chlamydial pathogenesis...
  15. Kemege K, Hickey J, Lovell S, Battaile K, Zhang Y, Hefty P. Ab initio structural modeling of and experimental validation for Chlamydia trachomatis protein CT296 reveal structural similarity to Fe(II) 2-oxoglutarate-dependent enzymes. J Bacteriol. 2011;193:6517-28 pubmed publisher
    ..Additionally, functional analyses did not support prior reports that CT296 has properties shared with divalent cation repressors such as Fur. ..
  16. Cousineau B, Cerpa C, Lefebvre J, Cedergren R. The sequence of the gene encoding elongation factor Tu from Chlamydia trachomatis compared with those of other organisms. Gene. 1992;120:33-41 pubmed
    ..Further peculiarities of the chlamydial and eubacterial sequences have been mapped to the X-ray crystallographic structure of the protein. ..
  17. Wagar E, Pang M. The gene for the S7 ribosomal protein of Chlamydia trachomatis: characterization within the chlamydial str operon. Mol Microbiol. 1992;6:327-35 pubmed
    ..Related findings and possible resistance mechanisms for the newly recognized tetracycline-resistant clinical isolates of C. trachomatis are discussed. ..
  18. Gray G, Kaul R, Roy K, Wenman W. Isolation and molecular characterization of the ribosomal protein L6 homolog from Chlamydia trachomatis. J Bacteriol. 1991;173:1663-9 pubmed
    ..Immunoblotting of purified ribosomes revealed functional, as well as antigenic, homology between the E. coli and C. trachomatis ribosomal L6 proteins. ..
  19. Birkelund S, Lundemose A, Christiansen G. The 75-kilodalton cytoplasmic Chlamydia trachomatis L2 polypeptide is a DnaK-like protein. Infect Immun. 1990;58:2098-104 pubmed
    ..This mixed promoter was recognized in E. coli...
  20. Gu L, Wenman W, Remacha M, Meuser R, Coffin J, Kaul R. Chlamydia trachomatis RNA polymerase alpha subunit: sequence and structural analysis. J Bacteriol. 1995;177:2594-601 pubmed
    ..coli RNA polymerase holoenzyme rather than its truncated variant lacking the amino terminus suggests the existence of structural conservation among alpha subunits from distantly related genera. ..
  21. Kahane S, Weinstein Y, Sarov I. Cloning, characterization and sequence of a novel 59-kDa protein of Chlamydia trachomatis. Gene. 1990;90:61-7 pubmed
    ..The cloned 59-kDa protein is neither related to the 60-kDa heat-shock protein found in many strains of bacteria, nor to the Cys-rich sarcosylinsoluble protein described in other studies of chlamydia. ..
  22. Bothe M, Dutow P, Pich A, Genth H, Klos A. DXD motif-dependent and -independent effects of the chlamydia trachomatis cytotoxin CT166. Toxins (Basel). 2015;7:621-37 pubmed publisher
    ..Taken together, CT166 affects various fundamental cellular processes, strongly suggesting its importance for the intracellular survival of chlamydia. ..
  23. Kaul R, Gray G, Koehncke N, Gu L. Cloning and sequence analysis of the Chlamydia trachomatis spc ribosomal protein gene cluster. J Bacteriol. 1992;174:1205-12 pubmed
    ..trachomatis r-proteins. Also, the intrinsic aminoglycoside resistance in C. trachomatis is unlikely to be mediated by CtrL6e since E. coli expressing CtrL6e remained susceptible to gentamicin (MIC less than 0.5 micrograms/ml). ..
  24. Raulston J, Davis C, Schmiel D, Morgan M, Wyrick P. Molecular characterization and outer membrane association of a Chlamydia trachomatis protein related to the hsp70 family of proteins. J Biol Chem. 1993;268:23139-47 pubmed
    ..R., Partin, J. S., and Lennarz, W. J. (1993) Science 259, 1421-1425). The potential involvement of an hsp70 protein in attachment may provide new insight on adherence mechanisms by obligate intracellular pathogens...
  25. Wylie J, Iliffe E, Wang L, McClarty G. Identification, characterization, and developmental regulation of Chlamydia trachomatis 3-deoxy-D-manno-octulosonate (KDO)-8-phosphate synthetase and CMP-KDO synthetase. Infect Immun. 1997;65:1527-30 pubmed
    ..Transcription of kdsA and kdsB in C. trachomatis was evident within 4 h of initiation of the C. trachomatis infection process and continued throughout the chlamydial life cycle. ..
  26. Scidmore Carlson M, Shaw E, Dooley C, Fischer E, Hackstadt T. Identification and characterization of a Chlamydia trachomatis early operon encoding four novel inclusion membrane proteins. Mol Microbiol. 1999;33:753-65 pubmed
  27. Scidmore M, Hackstadt T. Mammalian 14-3-3beta associates with the Chlamydia trachomatis inclusion membrane via its interaction with IncG. Mol Microbiol. 2001;39:1638-50 pubmed
    ..psittaci or C. pneumoniae inclusions. 14-3-3beta is the first eukaryotic protein found to interact with the chlamydial inclusion; however, its unique role in C. trachomatis pathogenesis remains to be determined...
  28. Fehlner Gardiner C, Roshick C, Carlson J, Hughes S, Belland R, Caldwell H, et al. Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase. J Biol Chem. 2002;277:26893-903 pubmed publisher
    ..coli and Salmonella TrpBs in displaying an absolute requirement for full-length TrpA. Taken together our data indicate that genital, but not ocular, serovars are capable of utilizing exogenous indole for the biosynthesis of tryptophan...
  29. Schwarzenbacher R, Stenner Liewen F, Liewen H, Robinson H, Yuan H, Bossy Wetzel E, et al. Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis. J Biol Chem. 2004;279:29320-4 pubmed publisher
    ..We conclude that CADD is a novel redox protein toxin unique to Chlamydia species and propose that both its redox activity and death domain binding ability are required for its biological activity...
  30. Borth N, Massier J, Franke C, Sachse K, Saluz H, H nel F. Chlamydial protease CT441 interacts with SRAP1 co-activator of estrogen receptor alpha and partially alleviates its co-activation activity. J Steroid Biochem Mol Biol. 2010;119:89-95 pubmed publisher
    ..This has clinical relevance as it has been proposed that disturbance of the balance between SRAP1-coding and non-coding SRA1 RNAs in breast tumor tissues might be involved in breast tumorigenesis...
  31. Barta M, Hickey J, Anbanandam A, Dyer K, Hammel M, Hefty P. Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding. PLoS ONE. 2014;9:e91760 pubmed publisher
    ..In combination with prior analysis of the essential location of specific nucleotides for ChxR recognition of DNA, a model of the full-length ChxR dimer bound to its cognate cis-acting element was generated. ..
  32. Rosario C, Hanson B, Tan M. The transcriptional repressor EUO regulates both subsets of Chlamydia late genes. Mol Microbiol. 2014;94:888-97 pubmed publisher
    ..We thus propose that EUO is the master regulator of late gene expression in the chlamydial developmental cycle. ..
  33. Zhang Y, Shi Y, Zhou M, Petsko G. Cloning, sequencing, and expression in Escherichia coli of the gene encoding a 45-kilodalton protein, elongation factor Tu, from Chlamydia trachomatis serovar F. J Bacteriol. 1994;176:1184-7 pubmed
    ..coli elongation factor Ts (EF-Ts). The GDP binding was specifically inhibited by the monoclonal antibody GP-45. These data suggest that the 45K is a chlamydial EF-Tu, and it forms a functional complex with E. coli EF-Ts protein. ..
  34. Myers G, Grinvalds R, Booth S, Hutton S, Binks M, Kemp D, et al. Expression of two novel proteins in Chlamydia trachomatis during natural infection. Microb Pathog. 2000;29:63-72 pubmed
    ..trachoImatic, collected from a Chlamydia -endemic population. These results suggest that the mvi -homologue and ctr48 are expressed by C. trachomatis during natural infection. ..
  35. Demkin V, Zimin A. A new amplification target for PCR-RFLP detection and identification of Chlamydiaceae species. Arch Microbiol. 2005;183:169-75 pubmed
  36. Danilition S, Maclean I, Peeling R, Winston S, Brunham R. The 75-kilodalton protein of Chlamydia trachomatis: a member of the heat shock protein 70 family?. Infect Immun. 1990;58:189-96 pubmed
    ..The 75-kDa protein appears to be a chlamydial homolog of hsp70, is immunoaccessible on native elementary bodies, and is a target for neutralization...
  37. Sayada C, Vretou E, Orfila J, Elion J, Denamur E. Heterogeneity within the first constant segment of the major outer membrane protein gene in Chlamydia trachomatis serovar D/Da distinguishes 2 lineages. C R Acad Sci III. 1995;318:943-9 pubmed
    ..The observed ompl genetic diversity of serovar D/Da strains in regions involved in T- and B-cell responses might add another level of complexity to the design of a subunit vaccine. ..
  38. Rosario C, Tan M. The early gene product EUO is a transcriptional repressor that selectively regulates promoters of Chlamydia late genes. Mol Microbiol. 2012;84:1097-107 pubmed publisher
    ..Thus, we propose that EUO is a master regulator that prevents the terminal differentiation of the replicating form of chlamydiae into the infectious form until sufficient rounds of replication have occurred...
  39. Engel J, Pollack J, Malik F, Ganem D. Cloning and characterization of RNA polymerase core subunits of Chlamydia trachomatis by using the polymerase chain reaction. J Bacteriol. 1990;172:5732-41 pubmed
    ..Immunoblots with this antibody demonstrated that the beta subunit appeared early in infection. ..
  40. Tipples G, McClarty G. Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase. J Biol Chem. 1995;270:7908-14 pubmed
    ..coli enzyme in that it is sensitive to inhibition by CTP, requires UTP, ATP, Mg2+, GTP, and glutamine for activity, and can also utilize ammonia as an amidogroup donor. ..
  41. Iliffe Lee E, McClarty G. Glucose metabolism in Chlamydia trachomatis: the 'energy parasite' hypothesis revisited. Mol Microbiol. 1999;33:177-87 pubmed
    ..In summary, identification and characterization of these glucose-catabolizing enzymes indicate that chlamydia contains the functional capacity to produce its own ATP and reducing power...
  42. Koehler J, Burgess R, Thompson N, Stephens R. Chlamydia trachomatis RNA polymerase major sigma subunit. Sequence and structural comparison of conserved and unique regions with Escherichia coli sigma 70 and Bacillus subtilis sigma 43. J Biol Chem. 1990;265:13206-14 pubmed
    ..Because the ability to study the genetics of C. trachomatis is currently limited, this work provides a tool for more detailed study of chlamydial promoter structure and of coordinate gene expression during the developmental cycle...
  43. Schmiel D, Wyrick P. Another putative heat-shock gene and aminoacyl-tRNA synthetase gene are located upstream from the grpE-like and dnaK-like genes in Chlamydia trachomatis. Gene. 1994;145:57-63 pubmed
    ..The other ORF has no significant homology to reported genes. We also examined the codon usage bias for these newly identified chlamydial ORFs and for previously reported chlamydial genes, and found them to be different from E. coli. ..
  44. Rockey D, Viratyosin W, Bannantine J, Suchland R, Stamm W. Diversity within inc genes of clinical Chlamydia trachomatis variant isolates that occupy non-fusogenic inclusions. Microbiology. 2002;148:2497-505 pubmed publisher
    ..trachomatis isolates. No change in the structure or the fusogenicity of the inclusions was associated with the presence or absence of CT223p...
  45. Gervassi A, Grabstein K, Probst P, Hess B, Alderson M, Fling S. Human CD8+ T cells recognize the 60-kDa cysteine-rich outer membrane protein from Chlamydia trachomatis. J Immunol. 2004;173:6905-13 pubmed
    ..The subcellular localization of OmcB to the cytosol of infected cells, as determined by conventional MHC class I Ag processing and presentation, suggests the possibility of an additional, cytosolic-associated function for this protein...
  46. Buetow L, Smith T, Dawson A, Fyffe S, Hunter W. Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis. Proc Natl Acad Sci U S A. 2007;104:4321-6 pubmed publisher
    ..The placement of UDP-N-acetylglucosamine and the FA provides details of N-acyltransferase ligand interactions and allows for a description of structure and reactivity at an early stage of LPS assembly...
  47. Rao X, Deighan P, Hua Z, Hu X, Wang J, Luo M, et al. A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary sigma subunit. Genes Dev. 2009;23:1818-29 pubmed publisher
    ..The strategy used here is generally applicable in cases where genetic tools are unavailable...
  48. Pais S, Milho C, Almeida F, Mota L. Identification of novel type III secretion chaperone-substrate complexes of Chlamydia trachomatis. PLoS ONE. 2013;8:e56292 pubmed publisher
    ..Overall, this indicated that in C. trachomatis Slc1 is a chaperone of multiple T3S substrates and that CT584 is a chaperone of the newly identified T3S substrate CT082...
  49. Belunis C, Mdluli K, Raetz C, Nano F. A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope. J Biol Chem. 1992;267:18702-7 pubmed
    ..Given the similarities of these two Kdo transferases and the essentiality of Kdo in Gram-negative bacteria, lipopolysaccharide biosynthesis may be a target for development of novel drugs effective against chlamydiae...
  50. Lundemose A, Rouch D, Birkelund S, Christiansen G, Pearce J. Chlamydia trachomatis Mip-like protein. Mol Microbiol. 1992;6:2539-48 pubmed
  51. Hayes L, Pickett M, Conlan J, Ferris S, Everson J, Ward M, et al. The major outer-membrane proteins of Chlamydia trachomatis serovars A and B: intra-serovar amino acid changes do not alter specificities of serovar- and C subspecies-reactive antibody-binding domains. J Gen Microbiol. 1990;136:1559-66 pubmed publisher
    ..Within a given serovar, however, limited interchange of functionally related amino acids may occur without impairing the binding of serovar-specific antibody...
  52. Tao S, Kaul R, Wenman W. Identification and nucleotide sequence of a developmentally regulated gene encoding a eukaryotic histone H1-like protein from Chlamydia trachomatis. J Bacteriol. 1991;173:2818-22 pubmed
    ..This protein appears to represent one of the few eukaryotic histonelike proteins described to date in prokaryotes...
  53. Cerrone M, Ma J, Stephens R. Cloning and sequence of the gene for heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of the protein. Infect Immun. 1991;59:79-90 pubmed
    ..trachomatis infections who may develop damaging sequelae, as well as providing tools for the study of immunopathogenic mechanisms of Chlamydia-induced disease...
  54. Lundemose A, Birkelund S, Fey S, Larsen P, Christiansen G. Chlamydia trachomatis contains a protein similar to the Legionella pneumophila mip gene product. Mol Microbiol. 1991;5:109-15 pubmed publisher
  55. Stephens R, Wagar E, Edman U. Developmental regulation of tandem promoters for the major outer membrane protein gene of Chlamydia trachomatis. J Bacteriol. 1988;170:744-50 pubmed
    ..Mapping of the initiating nucleotide for each transcript suggested that this gene is regulated by differential transcription from tandem promoters...
  56. Watson M, Lambden P, Ward M, Clarke I. Chlamydia trachomatis 60 kDa cysteine rich outer membrane protein: sequence homology between trachoma and LGV biovars. FEMS Microbiol Lett. 1989;53:293-7 pubmed
    ..Sequence analysis demonstrated a very high level of homology between the Jali 20/OT 60 kDa CrP and the previously published serovar L1 60 kDa CrP with only 8 out of 507 amino acid substitutions between the two proteins...
  57. Stephens R, Sanchez Pescador R, Wagar E, Inouye C, Urdea M. Diversity of Chlamydia trachomatis major outer membrane protein genes. J Bacteriol. 1987;169:3879-85 pubmed
    ..The molecular basis of omp1 gene diversity among C. trachomatis serovars was observed to be clustered nucleotide substitutions for closely related serovars and insertions or deletions for distantly related serovars...
  58. Dean D, Millman K. Molecular and mutation trends analyses of omp1 alleles for serovar E of Chlamydia trachomatis. Implications for the immunopathogenesis of disease. J Clin Invest. 1997;99:475-83 pubmed publisher
    ..Understanding the mutation trends, phylogeny, and molecular epidemiology of E variants is essential for designing public health control interventions and a vaccine...
  59. Stothard D, Boguslawski G, Jones R. Phylogenetic analysis of the Chlamydia trachomatis major outer membrane protein and examination of potential pathogenic determinants. Infect Immun. 1998;66:3618-25 pubmed
    ..Therefore, the role of MOMP in disease pathogenesis and infection may be passive, and it may not be the major ligand responsible for directing infection of various human cell types...
  60. Lister N, Tabrizi S, Fairley C, Smith A, Janssen P, Garland S. Variability of the Chlamydia trachomatis omp1 gene detected in samples from men tested in male-only saunas in Melbourne, Australia. J Clin Microbiol. 2004;42:2596-601 pubmed publisher
    ..trachomatis elsewhere. No significant genetic variants were found, as most variable positions were silent and were detected only in single samples...
  61. Delevoye C, Nilges M, Dautry Varsat A, Subtil A. Conservation of the biochemical properties of IncA from Chlamydia trachomatis and Chlamydia caviae: oligomerization of IncA mediates interaction between facing membranes. J Biol Chem. 2004;279:46896-906 pubmed publisher
  62. McCoy A, Adams N, Hudson A, Gilvarg C, Leustek T, Maurelli A. L,L-diaminopimelate aminotransferase, a trans-kingdom enzyme shared by Chlamydia and plants for synthesis of diaminopimelate/lysine. Proc Natl Acad Sci U S A. 2006;103:17909-14 pubmed publisher
  63. Qi M, Lei L, Gong S, Liu Q, DeLisa M, Zhong G. Chlamydia trachomatis secretion of an immunodominant hypothetical protein (CT795) into host cell cytoplasm. J Bacteriol. 2011;193:2498-509 pubmed publisher
    ..The above characterizations of CT795 have provided important information for further understanding the potential roles of CT795 in C. trachomatis pathogenesis...
  64. Zhang D, Fan H, McClarty G, Brunham R. Identification of the Chlamydia trachomatis RecA-encoding gene. Infect Immun. 1995;63:676-80 pubmed
    ..trachomatis suggests that homologous recombination may occur in this organism. The cloned C. trachomatis RecA-encoding gene will be useful for the construction of a recA mutant once a gene transfer system is developed for chlamydiae...
  65. Bannantine J, Stamm W, Suchland R, Rockey D. Chlamydia trachomatis IncA is localized to the inclusion membrane and is recognized by antisera from infected humans and primates. Infect Immun. 1998;66:6017-21 pubmed
    ..psittaci IncA and is also localized to the inclusion membrane. Immunoblot analysis demonstrated that sera from C. trachomatis-infected patients and from experimentally infected monkeys both recognized C. trachomatis IncA...
  66. Suchland R, Rockey D, Bannantine J, Stamm W. Isolates of Chlamydia trachomatis that occupy nonfusogenic inclusions lack IncA, a protein localized to the inclusion membrane. Infect Immun. 2000;68:360-7 pubmed
    ..trachomatis isolates that form nonfusing inclusions; the variant phenotype is associated with the absence of detectable IncA and with an altered incA sequence that modifies the characteristic hydrophobic domain of the IncA protein...
  67. Bannantine J, Griffiths R, Viratyosin W, Brown W, Rockey D. A secondary structure motif predictive of protein localization to the chlamydial inclusion membrane. Cell Microbiol. 2000;2:35-47 pubmed
  68. G rard H, Krausse Opatz B, Wang Z, Rudy D, Rao J, Zeidler H, et al. Expression of Chlamydia trachomatis genes encoding products required for DNA synthesis and cell division during active versus persistent infection. Mol Microbiol. 2001;41:731-41 pubmed
    ..These data explain, at least in part, the observed attenuation of new EB production during chlamydial persistence...
  69. Fields K, Fischer E, Hackstadt T. Inhibition of fusion of Chlamydia trachomatis inclusions at 32 degrees C correlates with restricted export of IncA. Infect Immun. 2002;70:3816-23 pubmed
    ..The data are consistent with a requirement for IncA in fusions of C. trachomatis inclusions and suggest that the effect of incubation at 32 degrees C is manifested by restricted export of IncA to the inclusion membrane...
  70. Hsu M, Tsai P, Chen K, Li L, Chiang C, Tsai J, et al. Genotyping of Chlamydia trachomatis from clinical specimens in Taiwan. J Med Microbiol. 2006;55:301-8 pubmed publisher
    ..018) between northern and southern Taiwan. Sequence mutation analysis by blast searching against GenBank reference sequences identified 12 genetic variants from a total of 102 omp1 gene sequences...
  71. Akers J, Tan M. Molecular mechanism of tryptophan-dependent transcriptional regulation in Chlamydia trachomatis. J Bacteriol. 2006;188:4236-43 pubmed publisher
  72. Jorgensen I, Valdivia R. Pmp-like proteins Pls1 and Pls2 are secreted into the lumen of the Chlamydia trachomatis inclusion. Infect Immun. 2008;76:3940-50 pubmed publisher
    ..Because Pls proteins lack classical sec-dependent secretion signals, we propose that Pls proteins are secreted into the inclusion lumen by a novel mechanism to regulate events important for chlamydial replication and inclusion expansion...
  73. Kiselev A, Skinner M, Lampe M. Analysis of pmpD expression and PmpD post-translational processing during the life cycle of Chlamydia trachomatis serovars A, D, and L2. PLoS ONE. 2009;4:e5191 pubmed publisher
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    ..Finally, CT153 localized to a distinct population of reticulate bodies, some of which were in contact with the inclusion membrane...
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    ..Since hydroxyurea inhibits ribonucleotide reductase and reduces intracellular deoxyribonucleotide levels, these results suggest that NrdR activity is modulated by a deoxyribonucleotide corepressor...
  77. Tattersall J, Rao G, Runac J, Hackstadt T, Grieshaber S, Grieshaber N. Translation inhibition of the developmental cycle protein HctA by the small RNA IhtA is conserved across Chlamydia. PLoS ONE. 2012;7:e47439 pubmed publisher
    ..As biolayer interferometry studies indicate that IhtA interacts directly with hctA message for all species tested, we predict that conserved sequences of IhtA are necessary for function and/or binding...
  78. Tjaden J, Winkler H, Schw ppe C, van der Laan M, M hlmann T, Neuhaus H. Two nucleotide transport proteins in Chlamydia trachomatis, one for net nucleoside triphosphate uptake and the other for transport of energy. J Bacteriol. 1999;181:1196-202 pubmed
    ..We conclude that Npt1Ct provides chlamydiae with energy whereas Npt2Ct catalyzes the net uptake of ribonucleoside triphosphates required for anabolic reactions...
  79. Bannantine J, Rockey D. Use of primate model system to identify Chlamydia trachomatis protein antigens recognized uniquely in the context of infection. Microbiology. 1999;145 ( Pt 8):2077-85 pubmed
    ..Collectively, these studies identify two C. trachomatis proteins that are under-represented in EBs and are recognized uniquely in the context of infection...
  80. Millman K, Tavar S, Dean D. Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism. J Bacteriol. 2001;183:5997-6008 pubmed publisher
    ..We provide examples of how genetic diversity generated by repeated recombination in these regions may be associated with evasion of immune surveillance, serovar-specific differences in tissue tropism, and persistence...
  81. Griffiths E, Gupta R. Protein signatures distinctive of chlamydial species: horizontal transfers of cell wall biosynthesis genes glmU from archaea to chlamydiae and murA between chlamydiae and Streptomyces. Microbiology. 2002;148:2541-9 pubmed publisher
    ..These signatures are also potentially useful for screening of the chlamydiae species...
  82. McCoy A, Sandlin R, Maurelli A. In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance. J Bacteriol. 2003;185:1218-28 pubmed
    ..Elucidating the existence of PG in Chlamydia spp. is of significance for the development of novel antibiotics targeting the chlamydial cell wall...
  83. Kutlin A, Kohlhoff S, Roblin P, Hammerschlag M, Riska P. Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis. Antimicrob Agents Chemother. 2005;49:903-7 pubmed publisher
    ..This is the first description of antibiotic resistance-associated mutations in C. pneumoniae and of rifampin resistance in C. trachomatis not associated with mutations in the rpoB gene...
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    ..Taken together, our results suggest that the metalloprotease inhibitors suppress chlamydial growth by targeting the bacterial PDF. These findings have important biochemical and medical implications...
  85. de la Maza L, Fielder T, Carlson E, Markoff B, Peterson E. Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis. Infect Immun. 1991;59:1196-201 pubmed
    ..When compared with the L3 serovar, the C and E serovars had 14 and 16 amino acid differences, respectively...
  86. Lambden P, Everson J, Ward M, Clarke I. Sulfur-rich proteins of Chlamydia trachomatis: developmentally regulated transcription of polycistronic mRNA from tandem promoters. Gene. 1990;87:105-12 pubmed
    ..Analysis of the upstream sequences, around the tsp for these mRNAs, revealed the presence of three inverted repeat structures that might act as binding domain(s) for a regulatory protein...
  87. Allen J, Stephens R. Identification by sequence analysis of two-site posttranslational processing of the cysteine-rich outer membrane protein 2 of Chlamydia trachomatis serovar L2. J Bacteriol. 1989;171:285-91 pubmed
    ..The mature proteins had a net positive charge and contained 24 cysteine residues...
  88. Clarke I, Ward M, Lambden P. Molecular cloning and sequence analysis of a developmentally regulated cysteine-rich outer membrane protein from Chlamydia trachomatis. Gene. 1988;71:307-14 pubmed
    ..Southern-blot analysis revealed that the cloned fragment is conserved in ten serovars of C. trachomatis and that a strongly cross-hybridising fragment is also present in Chlamydia psittaci...
  89. Mamat U, L bau S, Persson K, Brade H. Nucleotide sequence variations within the lipopolysaccharide biosynthesis gene gseA (Kdo transferase) among the Chlamydia trachomatis serovars. Microb Pathog. 1994;17:87-97 pubmed publisher
    ..Thus, although gseA was found to be highly conserved among C. trachomatis, the obtained TGGE profiles of the tested strains tended to correlate with their specific site of infection...
  90. Dessus Babus S, B b ar C, Charron A, B b ar C, de Barbeyrac B. Sequencing of gyrase and topoisomerase IV quinolone-resistance-determining regions of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained In vitro. Antimicrob Agents Chemother. 1998;42:2474-81 pubmed
    ..The gyrB, parC, and parE QRDRs of the resistant strains were identical to those of the reference strain. These results suggest that in C. trachomatis, DNA gyrase is the primary target of ofloxacin and sparfloxacin...
  91. Shen L, Shi Y, Douglas A, Hatch T, O Connell C, Chen J, et al. Identification and characterization of promoters regulating tuf expression in Chlamydia trachomatis serovar F. Arch Biochem Biophys. 2000;379:46-56 pubmed publisher
    ..coli or the in vitro transcription system. Our data suggest that multiple processes play a role in the regulation of tuf gene expression during the developmental cycle...
  92. Pannekoek Y, van der Ende A, Eijk P, Van Marle J, de Witte M, Ossewaarde J, et al. Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation. Infect Immun. 2001;69:4654-6 pubmed publisher
    ..Isolates representing the four sequence types expressed IncA in the membrane of one large single inclusion. In conclusion, the incA I47T mutation is not associated with the nonfusogenic phenotype...