chlamydia muridarum nigg

Summary

Alias: chlamydia muridarum str. nigg, chlamydia muridarum strain nigg, chlamydia trachomatis mopn strain nigg

Top Publications

  1. ncbi In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance
    Andrea J McCoy
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Bacteriol 185:1218-28. 2003
  2. ncbi Sulfur-rich proteins of Chlamydia trachomatis: developmentally regulated transcription of polycistronic mRNA from tandem promoters
    P R Lambden
    Department of Microbiology, University Medical School, Southampton General Hospital, U K
    Gene 87:105-12. 1990
  3. ncbi Identification by sequence analysis of two-site posttranslational processing of the cysteine-rich outer membrane protein 2 of Chlamydia trachomatis serovar L2
    J E Allen
    Department of Biomedical and Environmental Health Science, University of California, Berkeley 94720
    J Bacteriol 171:285-91. 1989
  4. ncbi Identification and characterization of promoters regulating tuf expression in Chlamydia trachomatis serovar F
    L Shen
    Evans Biomedical Research Center, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    Arch Biochem Biophys 379:46-56. 2000
  5. ncbi Elongation factor Ts of Chlamydia trachomatis: structure of the gene and properties of the protein
    Y Zhang
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Massachusetts 02118, USA
    Arch Biochem Biophys 344:43-52. 1997
  6. ncbi Sequencing of gyrase and topoisomerase IV quinolone-resistance-determining regions of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained In vitro
    S Dessus-Babus
    Laboratoire de Bacteriologie, Universite Bordeaux 2, 33076 Bordeaux Cedex, France
    Antimicrob Agents Chemother 42:2474-81. 1998
  7. ncbi The sequence of the groES and groEL genes from the mouse pneumonitis agent of Chlamydia trachomatis
    Y Ho
    Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine, MA 02118
    Gene 141:143-4. 1994
  8. ncbi Interrelationship between polymorphisms of incA, fusogenic properties of Chlamydia trachomatis strains, and clinical manifestations in patients in The Netherlands
    Yvonne Pannekoek
    Dept of Medical Microbiology, Academic Medical Center, University of Amsterdam, Room L1 115, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    J Clin Microbiol 43:2441-3. 2005
  9. ncbi Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial species
    B Kaltenboeck
    Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803
    J Bacteriol 175:487-502. 1993
  10. ncbi Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism
    K L Millman
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 94609, USA
    J Bacteriol 183:5997-6008. 2001

Scientific Experts

  • Y Pannekoek
  • V V Demkin
  • Andrei Kutlin
  • You-Xun Zhang
  • Guifeng Sun
  • Amit Balakrishnan
  • Andrea J McCoy
  • Emma Griffiths
  • K L Millman
  • L Shen
  • G S Myers
  • J Tjaden
  • Etsuko Sugawara
  • Luis M de la Maza
  • Hiroshi Nikaido
  • Sukumar Pal
  • Annahita K Sarcon
  • Ellena M Peterson
  • Melanie J Cocco
  • Soyoun Kim
  • Stephan A Sieber
  • Huizhou Fan
  • Niseema Pachikara
  • S Dessus-Babus
  • Ding Chen
  • Bhairavi Patel
  • Benjamin F Cravatt
  • Guangming Zhong
  • J N Engel
  • N S Thomas
  • D LaVerda
  • Anthony T Maurelli
  • Robin C Sandlin
  • M Tan
  • Radhey S Gupta
  • F M De La Vega
  • S Tavare
  • D Dean
  • S Booth
  • J M Chen
  • K S Sriprakash
  • T P Hatch
  • Y Shi
  • S I Hutton
  • I N Clarke
  • A L Douglas
  • R Grinvalds
  • C M O'Connell
  • D J Kemp
  • M Binks
  • H H Winkler
  • T Möhlmann
  • C Schwöppe
  • M van der Laan
  • H E Neuhaus
  • C Bebear
  • A Charron
  • B de Barbeyrac
  • C M Bebear
  • Y Ho
  • G I Byrne
  • C C Storey
  • M Lusher
  • G Guarneros
  • I G Old
  • D Ganem
  • B Wong
  • J M Galindo
  • B Kaltenboeck
  • E Perara
  • L M de la Maza
  • T J Fielder
  • E M Peterson
  • J Storz
  • K G Kousoulas
  • P R Lambden
  • J E Allen
  • B A Markoff
  • L M Sardinia
  • A M Coles
  • J Pollack
  • M E Ward
  • S Pal
  • F Malik
  • I Allan
  • J S Everson
  • R S Stephens
  • X Cheng
  • J H Pearce
  • E J Carlson

Detail Information

Publications33

  1. ncbi In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance
    Andrea J McCoy
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Bacteriol 185:1218-28. 2003
    ..Elucidating the existence of PG in Chlamydia spp. is of significance for the development of novel antibiotics targeting the chlamydial cell wall...
  2. ncbi Sulfur-rich proteins of Chlamydia trachomatis: developmentally regulated transcription of polycistronic mRNA from tandem promoters
    P R Lambden
    Department of Microbiology, University Medical School, Southampton General Hospital, U K
    Gene 87:105-12. 1990
    ..Analysis of the upstream sequences, around the tsp for these mRNAs, revealed the presence of three inverted repeat structures that might act as binding domain(s) for a regulatory protein...
  3. ncbi Identification by sequence analysis of two-site posttranslational processing of the cysteine-rich outer membrane protein 2 of Chlamydia trachomatis serovar L2
    J E Allen
    Department of Biomedical and Environmental Health Science, University of California, Berkeley 94720
    J Bacteriol 171:285-91. 1989
    ..The mature proteins had a net positive charge and contained 24 cysteine residues...
  4. ncbi Identification and characterization of promoters regulating tuf expression in Chlamydia trachomatis serovar F
    L Shen
    Evans Biomedical Research Center, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    Arch Biochem Biophys 379:46-56. 2000
    ..coli or the in vitro transcription system. Our data suggest that multiple processes play a role in the regulation of tuf gene expression during the developmental cycle...
  5. ncbi Elongation factor Ts of Chlamydia trachomatis: structure of the gene and properties of the protein
    Y Zhang
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Massachusetts 02118, USA
    Arch Biochem Biophys 344:43-52. 1997
    ..coli elongation factor Tu (EF-Tu). These data show that the second gene of the identified cluster is tsf. Unlike EF-Ts from any other species, its activity was comparable to that of E. coli EF-Ts in exchange reaction with E. coli EF-Tu...
  6. ncbi Sequencing of gyrase and topoisomerase IV quinolone-resistance-determining regions of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained In vitro
    S Dessus-Babus
    Laboratoire de Bacteriologie, Universite Bordeaux 2, 33076 Bordeaux Cedex, France
    Antimicrob Agents Chemother 42:2474-81. 1998
    ..The gyrB, parC, and parE QRDRs of the resistant strains were identical to those of the reference strain. These results suggest that in C. trachomatis, DNA gyrase is the primary target of ofloxacin and sparfloxacin...
  7. ncbi The sequence of the groES and groEL genes from the mouse pneumonitis agent of Chlamydia trachomatis
    Y Ho
    Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine, MA 02118
    Gene 141:143-4. 1994
    ..At the amino-acid level, the MoPn Hsp60 shows a 99% identity with those from C. trachomatis human strains. In a mouse model, MoPn Hsp60 could prove useful in deciphering the pathogenesis of human chlamydial diseases...
  8. ncbi Interrelationship between polymorphisms of incA, fusogenic properties of Chlamydia trachomatis strains, and clinical manifestations in patients in The Netherlands
    Yvonne Pannekoek
    Dept of Medical Microbiology, Academic Medical Center, University of Amsterdam, Room L1 115, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    J Clin Microbiol 43:2441-3. 2005
    ..Among these 96 strains, nine IncA sequence types were found, of which the three most frequently encountered (88% of the strains) were randomly distributed among symptomatic and asymptomatic patients...
  9. ncbi Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial species
    B Kaltenboeck
    Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803
    J Bacteriol 175:487-502. 1993
    ..trachomatis through biochemical characteristics. These data demonstrate that chlamydial ompA allelic relationships, except for human serovars of C. trachomatis, are cognate with chromosomal phylogenies...
  10. ncbi Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism
    K L Millman
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 94609, USA
    J Bacteriol 183:5997-6008. 2001
    ..We provide examples of how genetic diversity generated by repeated recombination in these regions may be associated with evasion of immune surveillance, serovar-specific differences in tissue tropism, and persistence...
  11. ncbi A polymerase chain reaction-based approach to cloning sigma factors from eubacteria and its application to the isolation of a sigma-70 homolog from Chlamydia trachomatis
    J N Engel
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    J Bacteriol 172:2447-55. 1990
    ..trachomatis. This PCR-based approach will be broadly applicable to the cloning of major sigma factors from other eubacteria...
  12. ncbi Transcriptional organization and regulation of the dnaK and groE operons of Chlamydia trachomatis
    M Tan
    Department of Medicine, University of California, San Francisco, 94143 0654, USA
    J Bacteriol 178:6983-90. 1996
    ..trachomatis RNA polymerase demonstrated that the regions containing the putative promoter elements of the dnaK and groE operons are functional, although heat shock-regulated expression could not be demonstrated...
  13. ncbi Use of monoclonal antibodies to facilitate identification, cloning, and purification of Chlamydia trachomatis hsp10
    D LaVerda
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison 53706, USA
    J Clin Microbiol 35:1209-15. 1997
    ..Purified chsp10 and specific anti-chsp10 monoclonal antibodies will be useful for investigating the biological and immunological roles of hsp10 in chlamydial infections...
  14. ncbi Protein signatures distinctive of chlamydial species: horizontal transfers of cell wall biosynthesis genes glmU from archaea to chlamydiae and murA between chlamydiae and Streptomyces
    Emma Griffiths
    Department of Biochemistry, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5
    Microbiology 148:2541-9. 2002
    ..These signatures are also potentially useful for screening of the chlamydiae species...
  15. ncbi The nucleotide and derived amino acid sequence of the omp2 gene of Chlamydia trachomatis serovar E
    A M Coles
    Microbial Molecular Genetics and Cell Biology Group, School of Biological Sciences, University of Birmingham, UK
    Nucleic Acids Res 18:6713. 1990
  16. ncbi Two nucleotide transport proteins in Chlamydia trachomatis, one for net nucleoside triphosphate uptake and the other for transport of energy
    J Tjaden
    Pflanzenphysiologie, Universitat Osnabruck, D 49069 Osnabruck, Germany
    J Bacteriol 181:1196-202. 1999
    ..We conclude that Npt1Ct provides chlamydiae with energy whereas Npt2Ct catalyzes the net uptake of ribonucleoside triphosphates required for anabolic reactions...
  17. ncbi Cloning and characterization of RNA polymerase core subunits of Chlamydia trachomatis by using the polymerase chain reaction
    J N Engel
    Department of Microbiology, University of California, San Francisco, 94143
    J Bacteriol 172:5732-41. 1990
    ..Immunoblots with this antibody demonstrated that the beta subunit appeared early in infection...
  18. ncbi Cloning, sequencing, and expression in Escherichia coli of the gene encoding a 45-kilodalton protein, elongation factor Tu, from Chlamydia trachomatis serovar F
    Y X Zhang
    Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine, Massachusetts 02118
    J Bacteriol 176:1184-7. 1994
    ..coli elongation factor Ts (EF-Ts). The GDP binding was specifically inhibited by the monoclonal antibody GP-45. These data suggest that the 45K is a chlamydial EF-Tu, and it forms a functional complex with E. coli EF-Ts protein...
  19. ncbi Comparison of the major outer-membrane protein (MOMP) gene of mouse pneumonitis (MoPn) and hamster SFPD strains of Chlamydia trachomatis with other Chlamydia strains
    Y X Zhang
    Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine, Massachusetts
    Mol Biol Evol 10:1327-42. 1993
    ..The branching pattern of this evolutionary tree is generally consistent with current classification based on serological, morphological, and other biological characteristics...
  20. ncbi Chlamydial gene encoding a 70-kilodalton antigen in Escherichia coli: analysis of expression signals and identification of the gene product
    L M Sardinia
    Department of Microbiology and Immunology, University of California Medical Center, San Francisco 94143
    J Bacteriol 171:335-41. 1989
    ..coli...
  21. ncbi A new amplification target for PCR-RFLP detection and identification of Chlamydiaceae species
    Vladimir V Demkin
    Laboratory of Molecular Diagnostics, Institute of Molecular Genetics RAS, Kurchatov sq 2, Moscow 123182, Russia
    Arch Microbiol 183:169-75. 2005
    ....
  22. ncbi Molecular cloning and sequence analysis of a developmentally regulated cysteine-rich outer membrane protein from Chlamydia trachomatis
    I N Clarke
    Department of Microbiology, University Medical School, Southampton General Hospital, U K
    Gene 71:307-14. 1988
    ..Southern-blot analysis revealed that the cloned fragment is conserved in ten serovars of C. trachomatis and that a strongly cross-hybridising fragment is also present in Chlamydia psittaci...
  23. ncbi Sequence of the gene encoding the major outer membrane protein of the mouse pneumonitis biovar of Chlamydia trachomatis
    T J Fielder
    Department of Pathology, University of California, Irvine 92717
    Gene 106:137-8. 1991
    ..This protein may be an ideal candidate for a vaccine in chlamydia-infected mouse experimental models...
  24. ncbi Heat shock response of murine Chlamydia trachomatis
    J N Engel
    Department of Microbiology and Immunology, University of California Medical Center, San Francisco 94143
    J Bacteriol 172:6959-72. 1990
    ..Thus, C. trachomatis utilizes at least two different pathways to induce the transcription of mRNAs encoding proteins induced in the heat shock response...
  25. ncbi Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies
    E M Peterson
    Department of Pathology, University of California, Irvine 92717
    Infect Immun 59:4147-53. 1991
    ..Therefore, the neutralizable domain of the epitope recognized by MAb E4 is contiguous and may be an important candidate for inclusion in a subunit vaccine...
  26. ncbi Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatis
    Guifeng Sun
    Department of Pathology and Laboratory Medicine, Medical Sciences, Room D440, University of California, Irvine, Irvine, CA 92697 4800, USA
    J Bacteriol 189:6222-35. 2007
    ..In conclusion, these results show that the native conformation of the MOMP of C. trachomatis is a trimer with predominantly a beta-sheet structure and porin function...
  27. ncbi Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatis
    L M de la Maza
    Department of Pathology, University of California, Irvine 92717
    Infect Immun 59:1196-201. 1991
    ..When compared with the L3 serovar, the C and E serovars had 14 and 16 amino acid differences, respectively...
  28. ncbi Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis
    Andrei Kutlin
    Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 49, Brooklyn, NY 11203, USA
    Antimicrob Agents Chemother 49:903-7. 2005
    ..This is the first description of antibiotic resistance-associated mutations in C. pneumoniae and of rifampin resistance in C. trachomatis not associated with mutations in the rpoB gene...
  29. ncbi Plasmid diversity in Chlamydia
    N S Thomas
    University of Southampton Medical School, Southampton General Hospital, UK
    Microbiology 143:1847-54. 1997
    ..The disruption of ORF 1 is the only significant variation identified amongst the chlamydial plasmids and could prove important for future vector development studies...
  30. ncbi A developmentally regulated chlamydial gene with apparent homology to eukaryotic histone H1
    E Perara
    Department of Microbiology and Immunology, University of California Medical Center, San Francisco 94143 0502
    Proc Natl Acad Sci U S A 89:2125-9. 1992
    ..These properties are consistent with a role either in the regulation of late gene expression or in the compaction of the chlamydial genome...
  31. ncbi Microbial genes homologous to the peptidyl-tRNA hydrolase-encoding gene of Escherichia coli
    F M De La Vega
    Departamento de Genetica y Biologia Molecular, Centro de Investigacion y Estudios Avanzados del I P N, Mexico
    Gene 169:97-100. 1996
    ..Previously known Ec pth mutations were located in highly conserved residues...
  32. ncbi Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium
    Amit Balakrishnan
    Graduate School of Biomedical Sciences, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
    J Biol Chem 281:16691-9. 2006
    ..Taken together, our results suggest that the metalloprotease inhibitors suppress chlamydial growth by targeting the bacterial PDF. These findings have important biochemical and medical implications...
  33. ncbi Expression of two novel proteins in Chlamydia trachomatis during natural infection
    G S Myers
    Menzies School of Health Research, Darwin, NT, Australia
    Microb Pathog 29:63-72. 2000
    ..trachoImatic, collected from a Chlamydia -endemic population. These results suggest that the mvi -homologue and ctr48 are expressed by C. trachomatis during natural infection...