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Genomes and GenesSpecies | chlamydia muridarum niggSummaryAlias: chlamydia muridarum str. nigg, chlamydia muridarum strain nigg, chlamydia trachomatis mopn strain nigg Top Publications
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In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistanceAndrea J McCoy
Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
J Bacteriol 185:1218-28. 2003..Elucidating the existence of PG in Chlamydia spp. is of significance for the development of novel antibiotics targeting the chlamydial cell wall...- Sulfur-rich proteins of Chlamydia trachomatis: developmentally regulated transcription of polycistronic mRNA from tandem promotersP R Lambden
Department of Microbiology, University Medical School, Southampton General Hospital, U K
Gene 87:105-12. 1990..Analysis of the upstream sequences, around the tsp for these mRNAs, revealed the presence of three inverted repeat structures that might act as binding domain(s) for a regulatory protein... - Identification by sequence analysis of two-site posttranslational processing of the cysteine-rich outer membrane protein 2 of Chlamydia trachomatis serovar L2J E Allen
Department of Biomedical and Environmental Health Science, University of California, Berkeley 94720
J Bacteriol 171:285-91. 1989..The mature proteins had a net positive charge and contained 24 cysteine residues... - Identification and characterization of promoters regulating tuf expression in Chlamydia trachomatis serovar FL Shen
Evans Biomedical Research Center, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
Arch Biochem Biophys 379:46-56. 2000..coli or the in vitro transcription system. Our data suggest that multiple processes play a role in the regulation of tuf gene expression during the developmental cycle... - Elongation factor Ts of Chlamydia trachomatis: structure of the gene and properties of the proteinY Zhang
Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Massachusetts 02118, USA
Arch Biochem Biophys 344:43-52. 1997..coli elongation factor Tu (EF-Tu). These data show that the second gene of the identified cluster is tsf. Unlike EF-Ts from any other species, its activity was comparable to that of E. coli EF-Ts in exchange reaction with E. coli EF-Tu... - Sequencing of gyrase and topoisomerase IV quinolone-resistance-determining regions of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained In vitroS Dessus-Babus
Laboratoire de Bacteriologie, Universite Bordeaux 2, 33076 Bordeaux Cedex, France
Antimicrob Agents Chemother 42:2474-81. 1998..The gyrB, parC, and parE QRDRs of the resistant strains were identical to those of the reference strain. These results suggest that in C. trachomatis, DNA gyrase is the primary target of ofloxacin and sparfloxacin... - The sequence of the groES and groEL genes from the mouse pneumonitis agent of Chlamydia trachomatisY Ho
Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine, MA 02118
Gene 141:143-4. 1994..At the amino-acid level, the MoPn Hsp60 shows a 99% identity with those from C. trachomatis human strains. In a mouse model, MoPn Hsp60 could prove useful in deciphering the pathogenesis of human chlamydial diseases... - Interrelationship between polymorphisms of incA, fusogenic properties of Chlamydia trachomatis strains, and clinical manifestations in patients in The NetherlandsYvonne Pannekoek
Dept of Medical Microbiology, Academic Medical Center, University of Amsterdam, Room L1 115, P O Box 22660, 1100 DD Amsterdam, The Netherlands
J Clin Microbiol 43:2441-3. 2005..Among these 96 strains, nine IncA sequence types were found, of which the three most frequently encountered (88% of the strains) were randomly distributed among symptomatic and asymptomatic patients... - Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial speciesB Kaltenboeck
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803
J Bacteriol 175:487-502. 1993..trachomatis through biochemical characteristics. These data demonstrate that chlamydial ompA allelic relationships, except for human serovars of C. trachomatis, are cognate with chromosomal phylogenies... - Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organismK L Millman
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 94609, USA
J Bacteriol 183:5997-6008. 2001..We provide examples of how genetic diversity generated by repeated recombination in these regions may be associated with evasion of immune surveillance, serovar-specific differences in tissue tropism, and persistence... - A polymerase chain reaction-based approach to cloning sigma factors from eubacteria and its application to the isolation of a sigma-70 homolog from Chlamydia trachomatisJ N Engel
Department of Microbiology and Immunology, University of California, San Francisco 94143
J Bacteriol 172:2447-55. 1990..trachomatis. This PCR-based approach will be broadly applicable to the cloning of major sigma factors from other eubacteria... - Transcriptional organization and regulation of the dnaK and groE operons of Chlamydia trachomatisM Tan
Department of Medicine, University of California, San Francisco, 94143 0654, USA
J Bacteriol 178:6983-90. 1996..trachomatis RNA polymerase demonstrated that the regions containing the putative promoter elements of the dnaK and groE operons are functional, although heat shock-regulated expression could not be demonstrated... - Use of monoclonal antibodies to facilitate identification, cloning, and purification of Chlamydia trachomatis hsp10D LaVerda
Department of Medical Microbiology and Immunology, University of Wisconsin, Madison 53706, USA
J Clin Microbiol 35:1209-15. 1997..Purified chsp10 and specific anti-chsp10 monoclonal antibodies will be useful for investigating the biological and immunological roles of hsp10 in chlamydial infections... - Protein signatures distinctive of chlamydial species: horizontal transfers of cell wall biosynthesis genes glmU from archaea to chlamydiae and murA between chlamydiae and StreptomycesEmma Griffiths
Department of Biochemistry, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5
Microbiology 148:2541-9. 2002..These signatures are also potentially useful for screening of the chlamydiae species... - The nucleotide and derived amino acid sequence of the omp2 gene of Chlamydia trachomatis serovar EA M Coles
Microbial Molecular Genetics and Cell Biology Group, School of Biological Sciences, University of Birmingham, UK
Nucleic Acids Res 18:6713. 1990 - Two nucleotide transport proteins in Chlamydia trachomatis, one for net nucleoside triphosphate uptake and the other for transport of energyJ Tjaden
Pflanzenphysiologie, Universitat Osnabruck, D 49069 Osnabruck, Germany
J Bacteriol 181:1196-202. 1999..We conclude that Npt1Ct provides chlamydiae with energy whereas Npt2Ct catalyzes the net uptake of ribonucleoside triphosphates required for anabolic reactions... - Cloning and characterization of RNA polymerase core subunits of Chlamydia trachomatis by using the polymerase chain reactionJ N Engel
Department of Microbiology, University of California, San Francisco, 94143
J Bacteriol 172:5732-41. 1990..Immunoblots with this antibody demonstrated that the beta subunit appeared early in infection... - Cloning, sequencing, and expression in Escherichia coli of the gene encoding a 45-kilodalton protein, elongation factor Tu, from Chlamydia trachomatis serovar FY X Zhang
Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine, Massachusetts 02118
J Bacteriol 176:1184-7. 1994..coli elongation factor Ts (EF-Ts). The GDP binding was specifically inhibited by the monoclonal antibody GP-45. These data suggest that the 45K is a chlamydial EF-Tu, and it forms a functional complex with E. coli EF-Ts protein... - Comparison of the major outer-membrane protein (MOMP) gene of mouse pneumonitis (MoPn) and hamster SFPD strains of Chlamydia trachomatis with other Chlamydia strainsY X Zhang
Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine, Massachusetts
Mol Biol Evol 10:1327-42. 1993..The branching pattern of this evolutionary tree is generally consistent with current classification based on serological, morphological, and other biological characteristics... - Chlamydial gene encoding a 70-kilodalton antigen in Escherichia coli: analysis of expression signals and identification of the gene productL M Sardinia
Department of Microbiology and Immunology, University of California Medical Center, San Francisco 94143
J Bacteriol 171:335-41. 1989..coli... - A new amplification target for PCR-RFLP detection and identification of Chlamydiaceae speciesVladimir V Demkin
Laboratory of Molecular Diagnostics, Institute of Molecular Genetics RAS, Kurchatov sq 2, Moscow 123182, Russia
Arch Microbiol 183:169-75. 2005.... - Molecular cloning and sequence analysis of a developmentally regulated cysteine-rich outer membrane protein from Chlamydia trachomatisI N Clarke
Department of Microbiology, University Medical School, Southampton General Hospital, U K
Gene 71:307-14. 1988..Southern-blot analysis revealed that the cloned fragment is conserved in ten serovars of C. trachomatis and that a strongly cross-hybridising fragment is also present in Chlamydia psittaci... - Sequence of the gene encoding the major outer membrane protein of the mouse pneumonitis biovar of Chlamydia trachomatisT J Fielder
Department of Pathology, University of California, Irvine 92717
Gene 106:137-8. 1991..This protein may be an ideal candidate for a vaccine in chlamydia-infected mouse experimental models... - Heat shock response of murine Chlamydia trachomatisJ N Engel
Department of Microbiology and Immunology, University of California Medical Center, San Francisco 94143
J Bacteriol 172:6959-72. 1990..Thus, C. trachomatis utilizes at least two different pathways to induce the transcription of mRNAs encoding proteins induced in the heat shock response... - Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodiesE M Peterson
Department of Pathology, University of California, Irvine 92717
Infect Immun 59:4147-53. 1991..Therefore, the neutralizable domain of the epitope recognized by MAb E4 is contiguous and may be an important candidate for inclusion in a subunit vaccine... - Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatisGuifeng Sun
Department of Pathology and Laboratory Medicine, Medical Sciences, Room D440, University of California, Irvine, Irvine, CA 92697 4800, USA
J Bacteriol 189:6222-35. 2007..In conclusion, these results show that the native conformation of the MOMP of C. trachomatis is a trimer with predominantly a beta-sheet structure and porin function... - Sequence diversity of the 60-kilodalton protein and of a putative 15-kilodalton protein between the trachoma and lymphogranuloma venereum biovars of Chlamydia trachomatisL M de la Maza
Department of Pathology, University of California, Irvine 92717
Infect Immun 59:1196-201. 1991..When compared with the L3 serovar, the C and E serovars had 14 and 16 amino acid differences, respectively... - Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatisAndrei Kutlin
Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 49, Brooklyn, NY 11203, USA
Antimicrob Agents Chemother 49:903-7. 2005..This is the first description of antibiotic resistance-associated mutations in C. pneumoniae and of rifampin resistance in C. trachomatis not associated with mutations in the rpoB gene... - Plasmid diversity in ChlamydiaN S Thomas
University of Southampton Medical School, Southampton General Hospital, UK
Microbiology 143:1847-54. 1997..The disruption of ORF 1 is the only significant variation identified amongst the chlamydial plasmids and could prove important for future vector development studies... - A developmentally regulated chlamydial gene with apparent homology to eukaryotic histone H1E Perara
Department of Microbiology and Immunology, University of California Medical Center, San Francisco 94143 0502
Proc Natl Acad Sci U S A 89:2125-9. 1992..These properties are consistent with a role either in the regulation of late gene expression or in the compaction of the chlamydial genome... - Microbial genes homologous to the peptidyl-tRNA hydrolase-encoding gene of Escherichia coliF M De La Vega
Departamento de Genetica y Biologia Molecular, Centro de Investigacion y Estudios Avanzados del I P N, Mexico
Gene 169:97-100. 1996..Previously known Ec pth mutations were located in highly conserved residues... - Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacteriumAmit Balakrishnan
Graduate School of Biomedical Sciences, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
J Biol Chem 281:16691-9. 2006..Taken together, our results suggest that the metalloprotease inhibitors suppress chlamydial growth by targeting the bacterial PDF. These findings have important biochemical and medical implications... - Expression of two novel proteins in Chlamydia trachomatis during natural infectionG S Myers
Menzies School of Health Research, Darwin, NT, Australia
Microb Pathog 29:63-72. 2000..trachoImatic, collected from a Chlamydia -endemic population. These results suggest that the mvi -homologue and ctr48 are expressed by C. trachomatis during natural infection...