Neisseria meningitidis MC58

Summary

Alias: Neisseria meningitidis serogroup B strain MC58

Top Publications

  1. Radstrom P, Fermer C, Kristiansen B, Jenkins A, Skold O, Swedberg G. Transformational exchanges in the dihydropteroate synthase gene of Neisseria meningitidis: a novel mechanism for acquisition of sulfonamide resistance. J Bacteriol. 1992;174:6386-93 pubmed
    ..The origin of the resistance-mediating segment of the gene is unknown, but hybridization results showed the presence of homologous dhps genes in Neisseria gonorrhoeae and N. lactamica but not in N. subflava or Branhamella catarrhalis. ..
  2. Pettersson A, van der Ley P, Poolman J, Tommassen J. Molecular characterization of the 98-kilodalton iron-regulated outer membrane protein of Neisseria meningitidis. Infect Immun. 1993;61:4724-33 pubmed
    ..However, the antibodies were not bactericidal in an in vitro assay with human complement. ..
  3. Maiden M, Bygraves J, Feil E, Morelli G, Russell J, Urwin R, et al. Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A. 1998;95:3140-5 pubmed
  4. Sacchi C, Whitney A, Popovic T, Beall D, Reeves M, Plikaytis B, et al. Diversity and prevalence of PorA types in Neisseria meningitidis serogroup B in the United States, 1992-1998. J Infect Dis. 2000;182:1169-76 pubmed
    ..Studies are needed to fully evaluate the extent of cross-protection in humans among the variants and prototypes in each PorA VR family. ..
  5. Prince S, Feron C, Janssens D, Lobet Y, Achtman M, Kusecek B, et al. Expression, refolding and crystallization of the OpcA invasin from Neisseria meningitidis. Acta Crystallogr D Biol Crystallogr. 2001;57:1164-6 pubmed
    ..9, b = 46.3, c = 74.0 A. Complete data sets of reflections were collected from native and refolded OpcA to 2.0 A resolution. ..
  6. Mellin J, Goswami S, Grogan S, Tjaden B, Genco C. A novel fur- and iron-regulated small RNA, NrrF, is required for indirect fur-mediated regulation of the sdhA and sdhC genes in Neisseria meningitidis. J Bacteriol. 2007;189:3686-94 pubmed
    ..This study is the first report of small RNAs in N. meningitidis and the first to use a bioinformatics approach to identify, a priori, regulatory targets of a small RNA. ..
  7. Schielke S, Huebner C, Spatz C, Nägele V, Ackermann N, Frosch M, et al. Expression of the meningococcal adhesin NadA is controlled by a transcriptional regulator of the MarR family. Mol Microbiol. 2009;72:1054-67 pubmed publisher
    ..Hence NmFarR has gained control over a meningococcus-specific gene involved in host colonization and thus contributed to divergent niche adaptation in pathogenic Neisseriae. ..
  8. van der Ley P, Heckels J, Virji M, Hoogerhout P, Poolman J. Topology of outer membrane porins in pathogenic Neisseria spp. Infect Immun. 1991;59:2963-71 pubmed
    ..These results suggest that the longest loops are immunodominant, provide the binding sites for bactericidal antibodies, and display the greatest variation among different strains. ..
  9. Elkins C, Thomas C, Seifert H, Sparling P. Species-specific uptake of DNA by gonococci is mediated by a 10-base-pair sequence. J Bacteriol. 1991;173:3911-3 pubmed
    ..We show that the presence of various forms of this 10-bp sequence results in increased uptake of double-stranded DNA into a DNase-resistant state and allows genetic transformation by an otherwise nontransformable plasmid. ..

More Information

Publications155 found, 100 shown here

  1. Fermer C, Kristiansen B, Skold O, Swedberg G. Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origin in other species. J Bacteriol. 1995;177:4669-75 pubmed
    ..This observation supports the idea of an interspecies transfer of genetic material in Neisseria species as a mechanism for the development of chromosomally mediated resistance. ..
  2. Merker P, Tommassen J, Kusecek B, Virji M, Sesardic D, Achtman M. Two-dimensional structure of the Opc invasin from Neisseria meningitidis. Mol Microbiol. 1997;23:281-93 pubmed
    ..The results thus confirm important predictions of the model and define five permissive sites within surface-exposed loops which can be used to insert foreign epitopes. ..
  3. Pizza M, Scarlato V, Masignani V, Giuliani M, Arico B, Comanducci M, et al. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science. 2000;287:1816-20 pubmed
  4. Prince S, Achtman M, Derrick J. Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis. Proc Natl Acad Sci U S A. 2002;99:3417-21 pubmed
    ..The structure, therefore, suggests a model for how adhesion of this important human pathogen to proteoglycan is mediated at the molecular level. ..
  5. Delany I, Grifantini R, Bartolini E, Rappuoli R, Scarlato V. Effect of Neisseria meningitidis fur mutations on global control of gene transcription. J Bacteriol. 2006;188:2483-92 pubmed
    ..We began to dissect the regulatory networks of Fur and the heat shock (stress) response in N. meningitidis, and the observed interlink between the two circuits is discussed. ..
  6. Carpenter E, Corbett A, Thomson H, Adacha J, Jensen K, Bergeron J, et al. AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis. EMBO J. 2007;26:1363-72 pubmed
    ..meningitidis under oxidative stress and during bloodstream infection. The novel functional pairing of NExo and NApe is widespread among bacteria and appears to have evolved independently on several occasions. ..
  7. Ieva R, Roncarati D, Metruccio M, Seib K, Scarlato V, Delany I. OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms. Mol Microbiol. 2008;70:1152-65 pubmed publisher
    ..In addition, our results provide an explanation for the altered OS resistance phenotypes seen in Neisseria mutant strains where, paradoxically, the oxyR mutants are more resistant than the wild type in oxidative killing assays. ..
  8. Fantappiè L, Metruccio M, Seib K, Oriente F, Cartocci E, Ferlicca F, et al. The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression. Infect Immun. 2009;77:1842-53 pubmed publisher
    ..Moreover, this study suggests that in meningococcus there is a large Hfq-mediated sRNA network which so far is largely unexplored. ..
  9. Pannekoek Y, Huis In t Veld R, Hopman C, Langerak A, Speijer D, van der Ende A. Molecular characterization and identification of proteins regulated by Hfq in Neisseria meningitidis. FEMS Microbiol Lett. 2009;294:216-24 pubmed publisher
    ..These results show that in N. meningitidis Hfq is involved in the regulation of a variety of components contributing to the survival and establishment of meningococcal disease. ..
  10. Achtman M, Neibert M, Crowe B, Strittmatter W, Kusecek B, Weyse E, et al. Purification and characterization of eight class 5 outer membrane protein variants from a clone of Neisseria meningitidis serogroup A. J Exp Med. 1988;168:507-25 pubmed
  11. Carbonnelle E, Helaine S, Prouvensier L, Nassif X, Pelicic V. Type IV pilus biogenesis in Neisseria meningitidis: PilW is involved in a step occurring after pilus assembly, essential for fibre stability and function. Mol Microbiol. 2005;55:54-64 pubmed
  12. Sa E Cunha C, Griffiths N, Murillo I, Virji M. Neisseria meningitidis Opc invasin binds to the cytoskeletal protein alpha-actinin. Cell Microbiol. 2009;11:389-405 pubmed publisher
    ..meningitidis Opc invasin. Since alpha-actinin is a modulator of a variety of signalling pathways and of cytoskeletal functions, its targeting by Opc may enable bacteria to survive/translocate across endothelial barriers. ..
  13. Goodman S, Scocca J. Identification and arrangement of the DNA sequence recognized in specific transformation of Neisseria gonorrhoeae. Proc Natl Acad Sci U S A. 1988;85:6982-6 pubmed
    ..This regulatory function might account for the origin and maintenance of recognition sequences in the chromosomes of Gram-negative transformable bacteria...
  14. Facius D, Meyer T. A novel determinant (comA) essential for natural transformation competence in Neisseria gonorrhoeae and the effect of a comA defect on pilin variation. Mol Microbiol. 1993;10:699-712 pubmed
    ..The results are in agreement with previous observations supporting the notion that multiple recombination pathways contribute to the variability of pilE...
  15. Fussenegger M, Facius D, Meier J, Meyer T. A novel peptidoglycan-linked lipoprotein (ComL) that functions in natural transformation competence of Neisseria gonorrhoeae. Mol Microbiol. 1996;19:1095-105 pubmed
    ..Homologous counterparts of the comL gene are found in Neisseria meningitidis as well as in several nonpathogenic Neisseria species...
  16. Comanducci M, Bambini S, Brunelli B, Adu Bobie J, Aric B, Capecchi B, et al. NadA, a novel vaccine candidate of Neisseria meningitidis. J Exp Med. 2002;195:1445-54 pubmed
    ..NadA induces strong bactericidal antibodies and is protective in the infant rat model suggesting that this protein may represent a novel antigen for a vaccine able to control meningococcal disease caused by three hypervirulent lineages...
  17. Jose J, Otto G, Meyer T. The integration site of the iga gene in commensal Neisseria sp. Mol Genet Genomics. 2003;269:197-204 pubmed publisher
    ..gonorrhoeae and N. meningitidis rather than being distributed by horizontal gene transfer. N. lactamica, which is more closely related to N. gonorrhoeae than other commensals, may have lost iga by deletion...
  18. Sacchi C, Lemos A, Brandt M, Whitney A, Melles C, Solari C, et al. Proposed standardization of Neisseria meningitidis PorA variable-region typing nomenclature. Clin Diagn Lab Immunol. 1998;5:845-55 pubmed
    ..This scheme will be useful in future classification and applied epidemiologic studies of N. meningitidis, being a systematic way of selecting PorA vaccine candidates and analyzing vaccine coverage and failure...
  19. Collins R, Saleem M, Derrick J. Purification and three-dimensional electron microscopy structure of the Neisseria meningitidis type IV pilus biogenesis protein PilG. J Bacteriol. 2007;189:6389-96 pubmed
  20. Hoehn G, Clark V. Isolation and nucleotide sequence of the gene (aniA) encoding the major anaerobically induced outer membrane protein of Neisseria gonorrhoeae. Infect Immun. 1992;60:4695-703 pubmed
  21. Drazek E, Stein D, Deal C. A mutation in the Neisseria gonorrhoeae rfaD homolog results in altered lipooligosaccharide expression. J Bacteriol. 1995;177:2321-7 pubmed
    ..6-kDa LOS component contains a conformational change or altered saccharide composition that interferes with immunoreactivity. ..
  22. Zhou J, Bowler L, Spratt B. Interspecies recombination, and phylogenetic distortions, within the glutamine synthetase and shikimate dehydrogenase genes of Neisseria meningitidis and commensal Neisseria species. Mol Microbiol. 1997;23:799-812 pubmed
  23. Mosimann S, Gilbert M, Dombroswki D, To R, Wakarchuk W, Strynadka N. Structure of a sialic acid-activating synthetase, CMP-acylneuraminate synthetase in the presence and absence of CDP. J Biol Chem. 2001;276:8190-6 pubmed publisher
    ..g. Neisseria, Haemophilus, group B streptococci, etc.). As such, the identification of the bacterial CMP-NeuAc synthetase active site can serve as a starting point for rational drug design strategies...
  24. Welsch J, Rossi R, Comanducci M, Granoff D. Protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a Neisseria meningitidis candidate vaccine. J Immunol. 2004;172:5606-15 pubmed
    ..meningitidis strains expressing GNA1870 subvariant 1 proteins. The data support GNA1870 as a promising vaccine candidate for prevention of meningococcal group B disease caused by GNA1870 variant 1 strains...
  25. Snyder L, Jarvis S, Saunders N. Complete and variant forms of the 'gonococcal genetic island' in Neisseria meningitidis. Microbiology. 2005;151:4005-13 pubmed publisher
    ..In N. meningitidis, a dif site is present in this location and also serves as the point of chromosomal integration of the GGI in this species...
  26. Maharjan S, Saleem M, Feavers I, Wheeler J, Care R, Derrick J. Dissection of the function of the RmpM periplasmic protein from Neisseria meningitidis. Microbiology. 2016;162:364-75 pubmed publisher
  27. Jennings M, Virji M, Evans D, Foster V, Srikhanta Y, Steeghs L, et al. Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidis. Mol Microbiol. 1998;29:975-84 pubmed
  28. Takahashi H, Tanaka H, Inouye H, Kuroki T, Watanabe Y, Yamai S, et al. Isolation from a healthy carrier and characterization of a Neisseria meningitidis strain that is deficient in gamma-Glutamyl aminopeptidase activity. J Clin Microbiol. 2002;40:3035-7 pubmed
    ..meningitidis isolate which lacked the activity due to the insertional mutation of the ggt gene, suggesting that naturally occurring N. meningitidis isolates do not always possess GGT activity...
  29. Collins R, Frye S, Kitmitto A, Ford R, T njum T, Derrick J. Structure of the Neisseria meningitidis outer membrane PilQ secretin complex at 12 A resolution. J Biol Chem. 2004;279:39750-6 pubmed publisher
  30. Zhang Q, Li Y, Tang C. The role of the exopolyphosphatase PPX in avoidance by Neisseria meningitidis of complement-mediated killing. J Biol Chem. 2010;285:34259-68 pubmed publisher
    ..Instead, expression of PPX modifies the interaction of N. meningitidis with the alternative pathway of complement activation...
  31. Wang X, Yang X, Yang C, Wu Z, Xu H, Shen Y. Crystal structure of outer membrane protein NMB0315 from Neisseria meningitidis. PLoS ONE. 2011;6:e26845 pubmed publisher
    ..Our studies improve the understanding of the catalytic mechanism of M23 metallopeptidases. ..
  32. Khairalla A, Omer S, Mahdavi J, Aslam A, Dufailu O, Self T, et al. Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters. Cell Microbiol. 2015;17:1008-20 pubmed publisher
    ..Finally, we show that App and MspA induce a dose-dependent increase in DC death via caspase-dependent apoptosis. Our data provide novel insights into the roles of App and MspA in meningococcal infection. ..
  33. Li M, Langford P, Kroll J. Inactivation of NMB0419, Encoding a Sel1-Like Repeat (SLR) Protein, in Neisseria meningitidis Is Associated with Differential Expression of Genes Belonging to the Fur Regulon and Reduced Intraepithelial Replication. Infect Immun. 2017;85: pubmed publisher
  34. Feil E, Carpenter G, Spratt B. Electrophoretic variation in adenylate kinase of Neisseria meningitidis is due to inter- and intraspecies recombination. Proc Natl Acad Sci U S A. 1995;92:10535-9 pubmed
    ..Recombination may, therefore, play a major role in the generation of electrophoretically detectable variation in housekeeping enzymes of some bacterial species...
  35. Jennings M, van der Ley P, Wilks K, Maskell D, Poolman J, Moxon E. Cloning and molecular analysis of the galE gene of Neisseria meningitidis and its role in lipopolysaccharide biosynthesis. Mol Microbiol. 1993;10:361-9 pubmed
    ..These results are consistent with an essential role for galE in the incorporation of galactose into meningococcal lipopolysaccharide...
  36. Karkhoff Schweizer R, Schryvers A, Schweizer H. Cloning and sequence analysis of the fur gene encoding an iron-regulatory protein of Neisseria meningitidis. Gene. 1994;141:139-40 pubmed
    ..The fur gene, encoding an iron-regulatory protein in Neisseria meningitidis strain B16B6, has been cloned and sequenced. Its product showed a high degree of homology to known Fur sequences. ..
  37. Legrain M, Mazarin V, Irwin S, Bouchon B, Quentin Millet M, Jacobs E, et al. Cloning and characterization of Neisseria meningitidis genes encoding the transferrin-binding proteins Tbp1 and Tbp2. Gene. 1993;130:73-80 pubmed
    ..These comparisons should be extended to other Neisseria strains in order to evaluate further this genetic divergence further...
  38. Jennings M, Hood D, Peak I, Virji M, Moxon E. Molecular analysis of a locus for the biosynthesis and phase-variable expression of the lacto-N-neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis. Mol Microbiol. 1995;18:729-40 pubmed
  39. Silva R, Menendez T, Alonso L, Iglesias E, Musacchio A, Leal M, et al. Characterisation of the lpdA gene from Neisseria meningitidis by polymerase chain reaction, restriction fragment length polymorphism and sequencing. FEMS Microbiol Lett. 1999;174:191-9 pubmed
    ..Although a total of five different PCR-RFLP patterns were present, nucleotide sequence determination showed that identity levels were as high as 93-99% among the N. meningitidis strains analysed. ..
  40. Boulanger M, Murphy M. Crystal structure of the soluble domain of the major anaerobically induced outer membrane protein (AniA) from pathogenic Neisseria: a new class of copper-containing nitrite reductases. J Mol Biol. 2002;315:1111-27 pubmed publisher
    ..A unique combination of structural effectors surrounding the type I copper site of sAnia contribute to a unusual visible absorption spectra with components observed previously in either green or blue type I copper sites...
  41. Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, et al. Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat Biotechnol. 2002;20:914-21 pubmed publisher
  42. Ieva R, Alaimo C, Delany I, Spohn G, Rappuoli R, Scarlato V. CrgA is an inducible LysR-type regulator of Neisseria meningitidis, acting both as a repressor and as an activator of gene transcription. J Bacteriol. 2005;187:3421-30 pubmed publisher
    ..The role of CrgA in the regulation of gene expression during the infectious cycle of N. meningitidis is discussed...
  43. Frosch M, M ller D, Bousset K, M ller A. Conserved outer membrane protein of Neisseria meningitidis involved in capsule expression. Infect Immun. 1992;60:798-803 pubmed
    ..Secondary structure analysis revealed that CtrA is anchored in the outer membrane by eight membrane-spanning amphipathic beta strands, a structure of proteins that function as porins...
  44. Mietzner T, Bolan G, Schoolnik G, Morse S. Purification and characterization of the major iron-regulated protein expressed by pathogenic Neisseriae. J Exp Med. 1987;165:1041-57 pubmed
    ..While the precise function of the MIRP is not known, the availability of this protein in pure and biologically relevant quantities will allow further studies to elucidate its pathobiologic function. ..
  45. Yang Q, Tinsley C, Gotschlich E. Novel lipoprotein expressed by Neisseria meningitidis but not by Neisseria gonorrhoeae. Infect Immun. 1995;63:1631-6 pubmed
    ..The significance of the remarkable conservation of these gonococcal genes is discussed. ..
  46. Brooks J, Fallon R, Heckels J. Sequence variation in class 1 outer membrane protein in Neisseria meningitidis isolated from patients with meningococcal infection and close household contacts. FEMS Microbiol Lett. 1995;128:145-50 pubmed
    ..These data demonstrate that it is possible to use sequence information to differentiate between potential sources of infection which appear identical using conventional serological methods. ..
  47. Perez Castillo A, Perez Castillo A, Saez Nieto J. Sequence of the penicillin-binding protein 2-encoding gene (penA) of Neisseria perflava/sicca. Gene. 1994;146:91-3 pubmed
    ..perflava/sicca. ..
  48. van der Ley P, Kramer M, Steeghs L, Kuipers B, Andersen S, Jennings M, et al. Identification of a locus involved in meningococcal lipopolysaccharide biosynthesis by deletion mutagenesis. Mol Microbiol. 1996;19:1117-25 pubmed
    ..The affected gene probably encodes the glycosyltransferase necessary for adding N-acetylglucosamine to heptose. ..
  49. Jennings M, Bisercic M, Dunn K, Virji M, Martin A, Wilks K, et al. Cloning and molecular analysis of the Isi1 (rfaF) gene of Neisseria meningitidis which encodes a heptosyl-2-transferase involved in LPS biosynthesis: evaluation of surface exposed carbohydrates in LPS mediated toxicity for human endothelial cells. Microb Pathog. 1995;19:391-407 pubmed
  50. Ropp P, Nicholas R. Cloning and characterization of the ponA gene encoding penicillin-binding protein 1 from Neisseria gonorrhoeae and Neisseria meningitidis. J Bacteriol. 1997;179:2783-7 pubmed
  51. Shih G, Kahler C, Carlson R, Rahman M, Stephens D. gmhX, a novel gene required for the incorporation of L-glycero-D-manno-heptose into lipooligosaccharide in Neisseria meningitidis. Microbiology. 2001;147:2367-77 pubmed
    ..GmhX is a novel enzyme required for the incorporation of L-glycero-D-manno-heptose into meningococcal LOS, and is a candidate for the 2-D-glycero-manno-heptose phosphatase of the heptose biosynthesis pathway. ..
  52. Edwards J, Entz D, Apicella M. Gonococcal phospholipase d modulates the expression and function of complement receptor 3 in primary cervical epithelial cells. Infect Immun. 2003;71:6381-91 pubmed
    ..Collectively, our data indicate that PLD augments CR3-mediated gonococcus invasion of and survival within cervical epithelia...
  53. Oomen C, van Ulsen P, van Gelder P, Feijen M, Tommassen J, Gros P. Structure of the translocator domain of a bacterial autotransporter. EMBO J. 2004;23:1257-66 pubmed publisher
  54. Rouquette Loughlin C, Balthazar J, Hill S, Shafer W. Modulation of the mtrCDE-encoded efflux pump gene complex of Neisseria meningitidis due to a Correia element insertion sequence. Mol Microbiol. 2004;54:731-41 pubmed publisher
    ..We conclude that the mtr efflux system in meningococci is subject to transcriptional regulation by IHF and post-transcriptional regulation by cleavage in the inverted repeat of the Correia element...
  55. Helm R, Seifert H. Frequency and rate of pilin antigenic variation of Neisseria meningitidis. J Bacteriol. 2010;192:3822-3 pubmed publisher
    ..Strain MC58 underwent pilin Av at a rate similar to that of N. gonorrhoeae strain MS11 but lower than that of N. gonorrhoeae strain FA1090. Pilin Av was undetectable in strain FAM18...
  56. Frye S, LÃ¥ng E, Beyene G, Balasingham S, Homberset H, Rowe A, et al. The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation. PLoS ONE. 2015;10:e0134954 pubmed publisher
    ..N-terminal PilG also interacted with the N-terminal region of PilQ, which previously was shown to bind DNA. Collectively, these data suggest that PilG and PilQ in concert bind DNA during Tfp-mediated transformation. ..
  57. Goodman S, Scocca J. Factors influencing the specific interaction of Neisseria gonorrhoeae with transforming DNA. J Bacteriol. 1991;173:5921-3 pubmed
    ..The average frequency of targets in chromosomal DNA of N. gonorrhoeae appears to be approximately one per 1,000 bp...
  58. Baccanari D, Tansik R, Paterson S, Stone D. Characterization and amino acid sequence of Neisseria gonorrhoeae dihydrofolate reductase. J Biol Chem. 1984;259:12291-8 pubmed
    ..Most of these identities are residues that have been implicated in the binding of NADPH and methotrexate to the E. coli and Lactobacillus casei reductases. ..
  59. Gotschlich E. Genetic locus for the biosynthesis of the variable portion of Neisseria gonorrhoeae lipooligosaccharide. J Exp Med. 1994;180:2181-90 pubmed
    ..It is likely that these structural features are responsible for the high-frequency genetic variation of gonococcal LOS...
  60. Swartley J, Stephens D. Co-transcription of a homologue of the formamidopyrimidine-DNA glycosylase (fpg) and lysophosphatidic acid acyltransferase (nlaA) in Neisseria meningitidis. FEMS Microbiol Lett. 1995;134:171-6 pubmed
    ..We further show that the meningococcal fpg is co-transcribed with nlaA, encoding a lysophosphatidic acid acyltransferase, and suggest that the DNA repair enzyme may be involved in the regulation of nlaA or its gene product...
  61. Mellies J, Jose J, Meyer T. The Neisseria gonorrhoeae gene aniA encodes an inducible nitrite reductase. Mol Gen Genet. 1997;256:525-32 pubmed
    ..Finally, we report investigations to determine whether AniA protein is involved in gonococcal pathogenesis...
  62. Cantalupo G, Bucci C, Salvatore P, Pagliarulo C, Roberti V, Lavitola A, et al. Evolution and function of the neisserial dam-replacing gene. FEBS Lett. 2001;495:178-83 pubmed
    ..This is associated with the presence of GATmeC, suggesting an alternative restriction-modification system (RM) specific for 5'-GATC-3', similar to Sau3AI-RM of Staphylococcus aureus 3A, Lactococcus lactis KR2 and Listeria monocytogenes...
  63. Ray T, Lewis L, Gulati S, Rice P, Ram S. Novel blocking human IgG directed against the pentapeptide repeat motifs of Neisseria meningitidis Lip/H.8 and Laz lipoproteins. J Immunol. 2011;186:4881-94 pubmed publisher
    ..We also propose that outer membrane vesicle-containing meningococcal vaccines may be more efficacious if purged of subversive immunogens such as H.8...
  64. Fazio C, Neri A, Renna G, Vacca P, Antonetti R, Barbui A, et al. Persistent occurrence of serogroup Y/sequence type (ST)-23 complex invasive meningococcal disease among patients aged five to 14 years, Italy, 2007 to 2013. Euro Surveill. 2015;20: pubmed publisher
    ..Overall, these findings generate scientific evidence for the use of the quadrivalent meningococcal conjugate vaccine in the five to 14 years age group. ..
  65. Edwards U, Frosch M. Sequence and functional analysis of the cloned Neisseria meningitidis CMP-NeuNAc synthetase. FEMS Microbiol Lett. 1992;75:161-6 pubmed
    ..coli K1. Enzymatic activity was confirmed in vitro and in vivo. Transformation of the CMP-NeuNAc defective E. coli K1 strain EV5 with the meningococcal CMP-NeuNAc synthetase could complement the defect in E. coli...
  66. Wolff K, Stern A. The class 3 outer membrane protein (PorB) of Neisseria meningitidis: gene sequence and homology to the gonococcal porin PIA. FEMS Microbiol Lett. 1991;67:179-85 pubmed
    ..The predicted protein sequence of the class 3 protein exhibits essential structural homology to the gonococcal porin PIA. The class 3 protein encoding gene was expressed in Escherichia coli under the control of an inducible promoter. ..
  67. Zhou D, Stephens D, Gibson B, Engstrom J, McAllister C, Lee F, et al. Lipooligosaccharide biosynthesis in pathogenic Neisseria. Cloning, identification, and characterization of the phosphoglucomutase gene. J Biol Chem. 1994;269:11162-9 pubmed
    ..5-kDa LOS of the parent NMB strain. The inability of N. meningitidis NMB-R6 and N. gonorrhoeae strain 1291-R6 to convert glucose 6-phosphate to glucose 1-phosphate results in the truncated LOS phenotype expressed by these mutants...
  68. Petering H, Hammerschmidt S, Frosch M, van Putten J, Ison C, Robertson B. Genes associated with meningococcal capsule complex are also found in Neisseria gonorrhoeae. J Bacteriol. 1996;178:3342-5 pubmed
    ..The organization of the region D and E genes in N. gonorrhoeae and N. meningitidis in relation to the cps genes provides some insight into the evolutionary origin of encapsulation in N. meningitidis. ..
  69. Lafaye C, Iwema T, Iwena T, Ferrer J, Kroll J, Griat M, et al. Preliminary crystallographic data of the three homologues of the thiol-disulfide oxidoreductase DsbA in Neisseria meningitidis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:111-4 pubmed publisher
    ..The best crystals were obtained using DsbA1 and DsbA3; they belong to the orthorhombic and tetragonal systems and diffract to 1.5 and 2.7 A resolution, respectively. ..
  70. Tunio S, Oldfield N, Berry A, Ala Aldeen D, Wooldridge K, Turner D. The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: surface localization and role in host cell adhesion. Mol Microbiol. 2010;76:605-15 pubmed publisher
    ..In summary, FBA is a highly conserved, surface exposed protein that is required for optimal adhesion of meningococci to human cells...
  71. Benam A, Lång E, Alfsnes K, Fleckenstein B, Rowe A, Hovland E, et al. Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation. Microbiology. 2011;157:1329-42 pubmed publisher
  72. Petricoin E, Danaher R, Stein D. Analysis of the lsi region involved in lipooligosaccharide biosynthesis in Neisseria gonorrhoeae. J Bacteriol. 1991;173:7896-902 pubmed
    ..The mutant was characterized by Southern blotting, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and Western blotting (immunoblotting) and found to be phenotypically identical to FA5100...
  73. Claus H, Friedrich A, Frosch M, Vogel U. Differential distribution of novel restriction-modification systems in clonal lineages of Neisseria meningitidis. J Bacteriol. 2000;182:1296-303 pubmed
  74. Power P, Roddam L, Dieckelmann M, Srikhanta Y, Tan Y, Berrington A, et al. Genetic characterization of pilin glycosylation in Neisseria meningitidis. Microbiology. 2000;146 ( Pt 4):967-79 pubmed publisher
    ..Analysis of nucleotide sequence homologies has suggested specific roles for pglB, pglC and pglD in the biosynthesis of the 2,4-diacetimido-2,4,6-trideoxyhexose structure...
  75. Harvey H, Porat N, Campbell C, Jennings M, Gibson B, Phillips N, et al. Gonococcal lipooligosaccharide is a ligand for the asialoglycoprotein receptor on human sperm. Mol Microbiol. 2000;36:1059-70 pubmed
    ..These data suggest that the ASGP-R on human sperm cells recognizes and binds wild-type gonococcal LOS. This interaction may contribute to the transmission of gonorrhea from infected males to their sexual partners...
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    ..A model of the type IV meningococcal pilus fiber, based on the X-ray crystal structure of the N. gonorrhoeae pilin subunit, fitted neatly into the cavity, demonstrating how PilQ could serve as a channel for the growing pilus fiber...
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    ..Whether FUMC has any physiological relevance to the pathogenesisity of Neisseriae must await future gene disruption or mutagenesis studies...
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    ..In order to investigate the role of the class 4 protein in the pathogenesis of meningococcal infection, we have used an erythromycin resistance gene in developing two meningococcal strains that lack class 4 protein...
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    ..In one instance two copies of the 152-bp repetitive sequence are separated by a 436-bp central region and are in an inverted orientation with respect to one another, resembling a compound transposable element...
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    ..No difference in iron utilization between the mutant and the parental strain was observed. A minor effect of the mutation on serum resistance was observed. A topology model for FrpB in the outer membrane is proposed...
  83. Arvidson C, So M. The Neisseria transcriptional regulator PilA has a GTPase activity. J Biol Chem. 1995;270:26045-8 pubmed
    ..6 microM at 37 degrees C...
  84. Hagman K, Pan W, Spratt B, Balthazar J, Judd R, Shafer W. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology. 1995;141 ( Pt 3):611-22 pubmed publisher
    ..We propose that the 13 bp inverted-repeat sequence represents a transcriptional control element that regulates expression of the mtrRCDE gene complex, thereby modulating levels of gonococcal susceptibility to HAs...
  85. Hammerschmidt S, Birkholz C, Z hringer U, Robertson B, van Putten J, Ebeling O, et al. Contribution of genes from the capsule gene complex (cps) to lipooligosaccharide biosynthesis and serum resistance in Neisseria meningitidis. Mol Microbiol. 1994;11:885-96 pubmed
    ..Sialylated LOS, but not the polysialic acid capsule, is necessary to confer complete serum resistance on the meningococcus by inhibition of the alternative complement pathway...
  86. Sandlin R, Stein D. Role of phosphoglucomutase in lipooligosaccharide biosynthesis in Neisseria gonorrhoeae. J Bacteriol. 1994;176:2930-7 pubmed
    ..6-kDa LOS component) was isolated. The construction of a site-specific deletion of this region in the chromosome of 1291 confirms the role of this open reading frame in LOS biosynthesis...
  87. Lau P, Forghani F, Labb D, Bergeron H, Brousseau R, H ltke H. The NlaIV restriction and modification genes of Neisseria lactamica are flanked by leucine biosynthesis genes. Mol Gen Genet. 1994;243:24-31 pubmed
    ..This gene context implies a possible new mode of gene regulation for the RM.NlaIV system, which would involve a mechanism similar to the recently discovered leucine/Lrp regulon in E. coli...
  88. Drake S, Koomey M. The product of the pilQ gene is essential for the biogenesis of type IV pili in Neisseria gonorrhoeae. Mol Microbiol. 1995;18:975-86 pubmed
    ..aeruginosa PilQ- mutants by virtue of their expression of rare pilus filaments. Taking these data into account, PilQ is proposed to function in the terminal steps of organelle biogenesis by acting as a pilus channel or pore...
  89. Nolte O. Rifampicin resistance in Neisseria meningitidis: evidence from a study of sibling strains, description of new mutations and notes on population genetics. J Antimicrob Chemother. 1997;39:747-55 pubmed
    ..This finding is discussed with respect to recent studies that indicate a more panmictic population structure within particular serogroups of N. meningitidis...
  90. Barten R, Meyer T. Cloning and characterisation of the Neisseria gonorrhoeae aroB gene. Mol Gen Genet. 1998;258:34-44 pubmed
    ..The aroB gene might be useful as a selectable marker and target for attenuation of a gonococcal live vaccine strain or as a biosafe laboratory strain...
  91. Bart A, Dankert J, van der Ende A. Antigenic variation of the class I outer membrane protein in hyperendemic Neisseria meningitidis strains in the netherlands. Infect Immun. 1999;67:3842-6 pubmed
    ..Phase variation of expression of the porA gene seems to account for most nonreacting strains. These results show that serosubtyping may underestimate the rise of a hyperendemic clone...
  92. Turner P, Thomas C, Stojiljkovic I, Elkins C, Kizel G, Ala Aldeen D, et al. Neisserial TonB-dependent outer-membrane proteins: detection, regulation and distribution of three putative candidates identified from the genome sequences. Microbiology. 2001;147:1277-90 pubmed publisher
    ..Furthermore, TdfH is worthy of future investigation as a potential meningococcal vaccine candidate as it is a highly conserved, widely distributed and surface-exposed outer-membrane protein...