Burkholderia mallei ATCC 23344

Summary

Alias: Burkholderia mallei str. ATCC 23344

Top Publications

  1. pmc Requirement of DNA repair mechanisms for survival of Burkholderia cepacia G4 upon degradation of trichloroethylene
    C M Yeager
    Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331 2902, USA
    Appl Environ Microbiol 67:5384-91. 2001
  2. pmc Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant
    Joanne M Stevens
    Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire, UK
    J Bacteriol 187:7857-62. 2005
  3. pmc Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts
    Claudia M Romero
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    BMC Genomics 7:228. 2006
  4. pmc Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei
    Ricky L Ulrich
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Infect Immun 72:1150-4. 2004
  5. ncbi mini-Tn7 insertion in bacteria with multiple glmS-linked attTn7 sites: example Burkholderia mallei ATCC 23344
    Kyoung Hee Choi
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    Nat Protoc 1:162-9. 2006
  6. pmc Alanine racemase mutants of Burkholderia pseudomallei and Burkholderia mallei and use of alanine racemase as a non-antibiotic-based selectable marker
    Sheryl L W Zajdowicz
    Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 6:e21523. 2011
  7. ncbi Type VI secretion is a major virulence determinant in Burkholderia mallei
    Mark A Schell
    Department of Microbiology, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 64:1466-85. 2007
  8. pmc Molecular typing of, and distribution of genetic markers among, Burkholderia cepacia complex isolates from Brazil
    Maria G Detsika
    Department of Medical Microbiology and Genitourinary Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
    J Clin Microbiol 41:4148-53. 2003
  9. pmc Functional reconstitution, gene isolation and topology modelling of porins from Burkholderia pseudomallei and Burkholderia thailandensis
    Jaruwan Siritapetawee
    School of Biochemistry, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
    Biochem J 377:579-87. 2004
  10. doi A disruption of ctpA encoding carboxy-terminal protease attenuates Burkholderia mallei and induces partial protection in CD1 mice
    Aloka B Bandara
    Center for Molecular Medicine and Infectious Diseases, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0342, USA
    Microb Pathog 45:207-16. 2008

Research Grants

  1. The Transcriptome of Pathogenic Aspergillus Fumigatus
    William Nierman; Fiscal Year: 2003
  2. Microarray Expression Analysis of Burkholderia Mallei
    William Nierman; Fiscal Year: 2003
  3. Regulation of Burkholderia mallei virulence genes
    William Nierman; Fiscal Year: 2005
  4. Host-Pathogen Interactions in Invasive Aspergillosis
    William Nierman; Fiscal Year: 2009
  5. Host-Pathogen Interactions in Invasive Aspergillosis
    WILLIAM CHARLES NIERMAN; Fiscal Year: 2010

Scientific Experts

  • Yoshiyuki Ohtsubo
  • E Mahenthiralingam
  • A B Bandara
  • T Coenye
  • Ricky L Ulrich
  • WILLIAM CHARLES NIERMAN
  • Pak Leung Ho
  • Claudia M Romero
  • M A Valvano
  • P Vandamme
  • Yu Wang
  • David DeShazer
  • Alban Ramette
  • John J LiPuma
  • Sheryl L W Zajdowicz
  • Mark A Schell
  • Roberto N De Guzman
  • Kyoung Hee Choi
  • Maria Plesa
  • George W Payne
  • Lingling Zhang
  • James M Tiedje
  • Joanne M Stevens
  • Jaruwan Siritapetawee
  • Virginie Storms
  • Karen Vermis
  • Ken Inose
  • Chanwit Tribuddharat
  • Patrick C Y Woo
  • Claudio Aguilar
  • Maria G Detsika
  • Chun Han Chan
  • Donald E Woods
  • Mary N Burtnick
  • Mladen Tomich
  • P C Woo
  • M Burtnick
  • C M Yeager
  • Jessica Jones-Carson
  • Michael G Jobling
  • Ronald E Gill
  • Randall K Holmes
  • Andres Vazquez-Torres
  • M F Rodrigues
  • S Tungpradabkul
  • Dan Chen
  • Wonpil Im
  • Chet W Egan
  • Andrew N Ouellette
  • H Stanley Kim
  • Jan Mrazek
  • Wilson J Ribot
  • Harry B Hines
  • Ernst E Brueggemann
  • Thenmalarchelvi Rathinavelan
  • Lyla Lipscomb
  • Wendy L Picking
  • Andrew J Weightman
  • T Hefin Jones
  • Jean Marie Ruysschaert
  • Y Kang
  • Pierre Cornelis
  • William D Picking
  • Guy Vandenbussche
  • L G van Waasbergen
  • Helen L Rose
  • Jean Pierre Hernalsteens
  • Herbert P Schweizer
  • Lowrie A Taylor
  • Mark P Stevens
  • Michael W Wood
  • Edouard E Galyov
  • Hans J Nelis
  • Heino Prinz
  • Wipa Suginta
  • Natasja Van Den Vreken
  • Monique Gillis
  • Richard H Ashley
  • Worada Samosornsuk
  • D E Stead
  • C Anthony Hart
  • Vittorio Venturi
  • Ami M Y Fung
  • Richard A Moore
  • Wai Ting Hui
  • Susanna K P Lau
  • Masako Fujikawa
  • Iris Bertani
  • Antonio H Y Ngan
  • Craig Winstanley

Detail Information

Publications40

  1. pmc Requirement of DNA repair mechanisms for survival of Burkholderia cepacia G4 upon degradation of trichloroethylene
    C M Yeager
    Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331 2902, USA
    Appl Environ Microbiol 67:5384-91. 2001
    ..cepacia G4 cells to survive following TCE transformation. A possible role for nucleotide excision repair and recombination repair activities in TCE-damaged cells is discussed...
  2. pmc Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant
    Joanne M Stevens
    Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire, UK
    J Bacteriol 187:7857-62. 2005
    ..pseudomallei bimA mutant. While the BimA homologs differ in their amino-terminal sequence, they interact directly with actin in vitro and vary in their ability to bind Arp3...
  3. pmc Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts
    Claudia M Romero
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    BMC Genomics 7:228. 2006
    More than 12,000 simple sequence repeats (SSRs) have been identified in the genome of Burkholderia mallei ATCC 23344. As a demonstrated mechanism of phase variation in other pathogenic bacteria, these may function as mutable loci leading ..
  4. pmc Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei
    Ricky L Ulrich
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Infect Immun 72:1150-4. 2004
    By creating mutations in the Burkholderia mallei ATCC 23344 animal pathogen-like type III secretion system (TTSS), this study analyzes the correlation between type III secretion and the pathogenicity of ATCC 23344 in vivo...
  5. ncbi mini-Tn7 insertion in bacteria with multiple glmS-linked attTn7 sites: example Burkholderia mallei ATCC 23344
    Kyoung Hee Choi
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1682, USA
    Nat Protoc 1:162-9. 2006
    ..This first chromosome integration system in B. mallei provides an important contribution to the genetic tools emerging for Burkholderia spp. Vectors are available for gene complementation and expression, and gene fusion analyses...
  6. pmc Alanine racemase mutants of Burkholderia pseudomallei and Burkholderia mallei and use of alanine racemase as a non-antibiotic-based selectable marker
    Sheryl L W Zajdowicz
    Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 6:e21523. 2011
    ..pseudomallei K96243. In addition, the alanine racemase deficient mutant of B. pseudomallei K96243 exhibited attenuation versus its isogenic parental strain with respect to growth and survival in murine peritoneal macrophages...
  7. ncbi Type VI secretion is a major virulence determinant in Burkholderia mallei
    Mark A Schell
    Department of Microbiology, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 64:1466-85. 2007
    ..Purified His-tagged BMAA0742 was recognized by glanders antiserum from a horse, a human and mice, indicating that this Hcp-family protein is produced in vivo during infection...
  8. pmc Molecular typing of, and distribution of genetic markers among, Burkholderia cepacia complex isolates from Brazil
    Maria G Detsika
    Department of Medical Microbiology and Genitourinary Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
    J Clin Microbiol 41:4148-53. 2003
    ..Nine genomovar IIIA isolates from different non-CF patients and clinical sources had identical genotypes, indicating the presence of a common clone...
  9. pmc Functional reconstitution, gene isolation and topology modelling of porins from Burkholderia pseudomallei and Burkholderia thailandensis
    Jaruwan Siritapetawee
    School of Biochemistry, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
    Biochem J 377:579-87. 2004
    ..Topology prediction and molecular modelling suggest that this newly-isolated and cloned porin is a 16-stranded beta-barrel and the external loops of the protein could be important determinants of the immune response to infection...
  10. doi A disruption of ctpA encoding carboxy-terminal protease attenuates Burkholderia mallei and induces partial protection in CD1 mice
    Aloka B Bandara
    Center for Molecular Medicine and Infectious Diseases, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0342, USA
    Microb Pathog 45:207-16. 2008
    ..mallei ATCC 23344. These findings suggest that CtpA regulates in vitro growth, cell morphology and intracellular survival of B. mallei, and a ctpA mutant protects CD1 mice against glanders...
  11. ncbi Proposal to accommodate Burkholderia cepacia genomovar VI as Burkholderia dolosa sp. nov
    Karen Vermis
    Laboratory for Pharmaceutical Microbiology, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Int J Syst Evol Microbiol 54:689-91. 2004
    ..cepacia-selective medium PCAT. Both 16S rDNA and recA RFLP analysis revealed unique B. dolosa restriction patterns. In addition, new 16S rDNA- and recA-based PCR assays allowed its specific identification...
  12. pmc Structural flexibility in the Burkholderia mallei genome
    William C Nierman
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:14246-51. 2004
    The complete genome sequence of Burkholderia mallei ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history. B...
  13. ncbi Polyphasic characterisation of Burkholderia cepacia-like isolates leading to the emended description of Burkholderia pyrrocinia
    Virginie Storms
    Laboratory for Microbiology, Faculty of Sciences, University of Ghent, Ghent, Belgium
    Syst Appl Microbiol 27:517-26. 2004
    ..cepacia complex species thus far comprising one single soil isolate only. An emended description of Burkholderia pyrrocinia is proposed. The taxonomic status of the remaining two isolates requires further analysis...
  14. pmc Quorum sensing: a transcriptional regulatory system involved in the pathogenicity of Burkholderia mallei
    Ricky L Ulrich
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, MD 21702, USA
    Infect Immun 72:6589-96. 2004
    ..An in silico analysis of the Burkholderia mallei ATCC 23344 genome revealed that it encodes at least two luxI and four luxR homologues...
  15. pmc Species abundance and diversity of Burkholderia cepacia complex in the environment
    Alban Ramette
    Center for Microbial Ecology, 540 Plant and Soil Sciences Building, Michigan State University, East Lansing, MI 48824 1325, USA
    Appl Environ Microbiol 71:1193-201. 2005
    ..cepacia complex species and closely related strains of the same species may coexist at high population levels but also species composition and abundance may dramatically vary between individual plants...
  16. pmc Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH
    Yu Wang
    Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, Lawrence, KA 66045, USA
    J Mol Biol 371:1304-14. 2007
    ..typhimurium and S. flexneri...
  17. ncbi The SlyB outer membrane lipoprotein of Burkholderia multivorans contributes to membrane integrity
    Maria Plesa
    Flanders Interuniversity Institute of Biotechnology VIB6, Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Vrije Universiteit Brussel, Building E, room 6 6, Pleinlaan 2, B 1050 Brussels, Belgium
    Res Microbiol 157:582-92. 2006
    ..Taken together, these phenotypes suggest that SlyB contributes to the integrity of the cell envelope. By PCR amplification we were also able to demonstrate the conservation of slyB in all B. cepacia complex species tested...
  18. ncbi Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei
    Lingling Zhang
    Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
    J Mol Biol 359:322-30. 2006
    ....
  19. ncbi Application of a recA gene-based identification approach to the maize rhizosphere reveals novel diversity in Burkholderia species
    George W Payne
    Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK
    FEMS Microbiol Lett 259:126-32. 2006
    ....
  20. ncbi Identification of a response regulator gene for catabolite control from a PCB-degrading beta-proteobacteria, Acidovorax sp. KKS102
    Yoshiyuki Ohtsubo
    Department of Environmental Life Sciences, Graduate School of Life Sciences, 2 1 1 Katahira, Sendai 980 8577, Japan
    Mol Microbiol 60:1563-75. 2006
    ..The genes highly similar to bphQ were found from several beta-proteobacteria, such as Burkholderia cenocepacia J2315, B. multivorans ATCC17616, B. xenovorans LB400 and Ralstonia solanacearum RS1085...
  21. pmc Seronegative bacteremic melioidosis caused by Burkholderia pseudomallei with ambiguous biochemical profile: clinical importance of accurate identification by 16S rRNA gene and groEL gene sequencing
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 41:3973-7. 2003
    ..Sequencing of the groEL gene showed that the isolate was B. pseudomallei. Proper identification of the bacterium in this study is crucial, since there would be a radical difference in the duration of antimicrobial therapy...
  22. ncbi Development of a species-specific recA-based PCR test for Burkholderia fungorum
    Chun Han Chan
    Department of Biological Sciences, Imperial College London, Sir Alexander Fleming Building, Imperial College Road, London SW7 2AZ, UK
    FEMS Microbiol Lett 224:133-8. 2003
    ..Using a similar procedure we extended the recA-based PCR assay to identify B. sacchari and B. caledonica, two additional soil-inhabiting Burkholderia spp...
  23. ncbi Burkholderia ambifaria sp. nov., a novel member of the Burkholderia cepacia complex including biocontrol and cystic fibrosis-related isolates
    T Coenye
    Laboratorium voor Microbiologie, Universiteit Gent, Ghent, Belgium
    Int J Syst Evol Microbiol 51:1481-90. 2001
    ..cepacia complex would be ill-advised until more is known about their potential pathogenic mechanisms...
  24. ncbi Cloning and characterisation of malE in Burkholderia pseudomallei
    P C Woo
    Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Med Microbiol 50:330-8. 2001
    ..Further studies on serodiagnosis of melioidosis with recombinant MBP should be performed...
  25. ncbi Identification of the acid phosphatase (acpA) gene homologues in pathogenic and non-pathogenic Burkholderia spp. facilitates TnphoA mutagenesis
    M Burtnick
    Dept of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Microbiology 147:111-20. 2001
    ..Two such systems have been successfully utilized in Burkholderia spp. for the identification of several genes encoding exported proteins...
  26. ncbi Polyhydroxyalkanoate accumulation in Burkholderia sp.: a molecular approach to elucidate the genes involved in the formation of two homopolymers consisting of short-chain-length 3-hydroxyalkanoic acids
    M F Rodrigues
    Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Germany
    Appl Microbiol Biotechnol 53:453-60. 2000
    ..The arrangement of the three genes is quite similar to the R. eutropha poly-beta-hydroxybutyrate biosynthesis operon...
  27. ncbi PCR-RFLP analysis of the flagellin sequences for identification of Burkholderia pseudomallei and Burkholderia cepacia from clinical isolates
    S Tungpradabkul
    Faculty of Science, Mahidol University, Rama VI Rd, Bangkok, 10400, Thailand
    Mol Cell Probes 13:99-105. 1999
    ..cepacia, to enable flagellin-type identification on the basis of the pattern of restriction fragments. In addition, the flagellin gene should be of considerable use as a genetic marker for clinical identification of these organisms...
  28. pmc Characterization of genes involved in biosynthesis of a novel antibiotic from Burkholderia cepacia BC11 and their role in biological control of Rhizoctonia solani
    Y Kang
    Department of Microbiology, University of Georgia, Athens, Georgia 30602, USA
    Appl Environ Microbiol 64:3939-47. 1998
    ..DNA sequence analysis suggested that this region encodes proteins directly involved in the production of a nonribosomally synthesized lipopeptide...
  29. ncbi Construction of a recA mutant of Burkholderia (formerly Pseudomonas), cepacia
    L G van Waasbergen
    Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater 74078, USA
    Appl Microbiol Biotechnol 49:59-65. 1998
    ..cepacia and a recA mutant will be useful in bioengineering of this species...
  30. pmc Genetic organization and sequence of the Pseudomonas cepacia genes for the alpha and beta subunits of protocatechuate 3,4-dioxygenase
    G J Zylstra
    Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor 48109 0620
    J Bacteriol 171:5915-21. 1989
    ..The deduced amino acid sequence showed extensive homology with the previously determined amino acid sequence of protocatechuate 3,4-dioxygenase from another Pseudomonas species...
  31. pmc Molecular and physical characterization of Burkholderia mallei O antigens
    Mary N Burtnick
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    J Bacteriol 184:849-52. 2002
    ..pseudomallei O polysaccharide (O-PS). In this study, we identified the O-PS biosynthetic gene cluster from B. mallei ATCC 23344 and subsequently characterized the molecular structure of the O-PS produced by this organism...
  32. pmc Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition
    Chanwit Tribuddharat
    Department of Microbiology, Mahidol University, Bangkok 10700, Thailand
    Antimicrob Agents Chemother 47:2082-7. 2003
    ..pseudomallei penA gene revealed a putative regulator gene located downstream of penA. We have cloned and sequenced the penA gene from B. mallei and found it to be identical to penA from B. pseudomallei...
  33. pmc Quorum-sensing system and stationary-phase sigma factor (rpoS) of the onion pathogen Burkholderia cepacia genomovar I type strain, ATCC 25416
    Claudio Aguilar
    Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Appl Environ Microbiol 69:1739-47. 2003
    ..cepacia has a negative effect on rpoS expression as determined by using an rpoS-lacZ transcriptional fusion; on the other hand, rpoS-null mutants displayed no difference in the accumulation of HSL signal molecules...
  34. ncbi Cloning and expression of the gene encoding catalytic subunit of thermostable glucose dehydrogenase from Burkholderia cepacia in Escherichia coli
    Ken Inose
    Department of Biotechnology, Tokyo University of Agriculture and Technology, 2 24 16 Naka machi, Tokyo Koganei 184 8588, Japan
    Biochim Biophys Acta 1645:133-8. 2003
    ..The deduced primary structure of gamma subunit showed about 30% identity to the small subunits of the SDH from G. oxydans and 2KGDHs from E. herbicola and P. citrea...
  35. ncbi Characterization of a laboratory-generated variant of BPS beta-lactamase from Burkholderia pseudomallei that hydrolyses ceftazidime
    P L Ho
    Department of Microbiology and HKU Pasteur Research Centre, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong SAR, China
    J Antimicrob Chemother 50:723-6. 2002
    ..coli conferred resistance to ceftazidime (MIC >or= 32 mg/L). The amino acid sequence of BPS-1m differed from that of BPS-1 by a Pro-to-Ser change at position 167 in the omega loop...
  36. ncbi Burkholderia cepacia complex infection in patients with cystic fibrosis
    Eshwar Mahenthiralingam
    Cardiff School of Biosciences, Cardiff University, Wales, UK
    J Med Microbiol 51:533-8. 2002
    ..For microbiologists, hospital infection control officers, caregivers, and most of all the CF community, the changes in our understanding of the taxonomy, epidemiology and pathogenesis of the bacterium 'B. cepacia' are complex...
  37. ncbi Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound results of new molecular diagnostic tools
    Peter Vandamme
    Laboratorium voor Microbiologie, Universiteit Gent, Ghent, Belgium
    FEMS Immunol Med Microbiol 33:143-9. 2002
    ..cepacia complex. This highlights another potential source for diagnostic problems with B. cepacia-like bacteria...
  38. pmc Role of flagella in host cell invasion by Burkholderia cepacia
    Mladen Tomich
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 0312, USA
    Infect Immun 70:1799-806. 2002
    ..cepacia. Our findings indicate that flagellum-mediated motility may facilitate penetration of host epithelial barriers by B. cepacia, contributing to establishment of infection and systemic spread of the organism...
  39. ncbi Cloning, sequencing, and transcriptional analysis of the recA gene of Pseudomonas cepacia
    T Nakazawa
    Department of Microbiology, Yamaguchi University School of Medicine, Japan
    Gene 94:83-8. 1990
    ..An SOS box characteristic to LexA-regulated promoters, along with the -10 and -35 consensus sequences, was found in the 5' upstream region of the P. cepacia recA gene...
  40. ncbi Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides
    Miguel A Valvano
    Department of Microbiology and Immunology and Medicine, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Microbiology 148:1979-89. 2002

Research Grants9

  1. The Transcriptome of Pathogenic Aspergillus Fumigatus
    William Nierman; Fiscal Year: 2003
    ..abstract_text> ..
  2. Microarray Expression Analysis of Burkholderia Mallei
    William Nierman; Fiscal Year: 2003
    ..Function and virulence validation of the identified virulence genes will be explored by construction and phenotype analysis of targeted knockout strains. ..
  3. Regulation of Burkholderia mallei virulence genes
    William Nierman; Fiscal Year: 2005
    ..It will provide critical information on virulence control and virulence mechanisms of B. mallei and will be crucial to the development of effective therapeutic interventions and vaccine strategies. ..
  4. Host-Pathogen Interactions in Invasive Aspergillosis
    William Nierman; Fiscal Year: 2009
    ..necessary to maintain protective immunity against the invading fungus. This hithertn inaccessible ... in order to >.E =.m m'- N'3 ..' 'C3 _.n '-' a.. m._ o'< m- ..
  5. Host-Pathogen Interactions in Invasive Aspergillosis
    WILLIAM CHARLES NIERMAN; Fiscal Year: 2010
    ..necessary to maintain protective immunity against the invading fungus. This hithertn inaccessible ... in order to >.E =.m m'- N'3 ..' 'C3 _.n '-' a.. m._ o'< m- ..