Streptococcus agalactiae 2603V/R

Summary

Alias: Streptococcus agalactiae str. 2603V/R, Streptococcus agalactiae 2603VR

Top Publications

  1. Luan S, Granlund M, Norgren M. An inserted DNA fragment with plasmid features is uniquely associated with the presence of the GBSi1 group II intron in Streptococcus agalactiae. Gene. 2003;312:305-12 pubmed
    ..This DNA fragment contained a partial transposase and putative plasmid related proteins. This may suggest that GBSi1 once was brought into the S. agalactiae genome by an integrated plasmid. ..
  2. Hedegaard J, Hauge M, Fage Larsen J, Mortensen K, Kilian M, Sperling Petersen H, et al. Investigation of the translation-initiation factor IF2 gene, infB, as a tool to study the population structure of Streptococcus agalactiae. Microbiology. 2000;146 ( Pt 7):1661-70 pubmed
    ..agalactiae, yielding an evolutionary tree which had a topology similar to a tree constructed using 16S rRNA sequences from the same species. ..
  3. Fleming K, Bohnsack J, Palacios G, Takahashi S, Adderson E. Equivalence of high-virulence clonotypes of serotype III group B Streptococcus agalactiae (GBS). J Med Microbiol. 2004;53:505-8 pubmed
    ..HVC and RDP type III-3 represent the same genetically related group of bacteria. The characteristic growth differences of virulent strains of type III GBS, however, are not directly attributable to differences in fba. ..
  4. Rantanen M, Lehtiƶ L, Rajagopal L, Rubens C, Goldman A. Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution. Acta Crystallogr D Biol Crystallogr. 2007;63:738-43 pubmed
  5. Wang E, Wang K, Chen D, Geng Y, Huang L, Wang J, et al. Molecular cloning and bioinformatic analysis of the Streptococcus agalactiae neuA gene isolated from tilapia. Genet Mol Res. 2015;14:6003-17 pubmed publisher
    ..S. agalactiae neuA from tilapia maintains high structural homology and sequence identity with CMP-NeuNAc synthetases from other bacteria. ..
  6. Toniolo C, Balducci E, Romano M, Proietti D, Ferlenghi I, Grandi G, et al. Streptococcus agalactiae capsule polymer length and attachment is determined by the proteins CpsABCD. J Biol Chem. 2015;290:9521-32 pubmed publisher
    ..e. the balance between polymerization and attachment to the cell wall). ..
  7. Haft R, Wessels M, Mebane M, Conaty N, Rubens C. Characterization of cpsF and its product CMP-N-acetylneuraminic acid synthetase, a group B streptococcal enzyme that can function in K1 capsular polysaccharide biosynthesis in Escherichia coli. Mol Microbiol. 1996;19:555-63 pubmed
    ..We concluded that cpsF encodes CMP-Neu5Ac synthetase in type III GBS, and that the GBS enzyme can function in the capsule-synthesis of a heterologous bacterial species...
  8. Nakamichi Y, Oiki S, Mikami B, Murata K, Hashimoto W. Conformational Change in the Active Site of Streptococcal Unsaturated Glucuronyl Hydrolase Through Site-Directed Mutagenesis at Asp-115. Protein J. 2016;35:300-9 pubmed publisher
    ..This interaction between Asn-115 and Asp-175 probably prevents the mutants from triggering the enzyme reaction using Asp-175 as an acid catalyst. ..
  9. Fontaine M, Perez Casal J, Song X, Shelford J, Willson P, Potter A. Immunisation of dairy cattle with recombinant Streptococcus uberis GapC or a chimeric CAMP antigen confers protection against heterologous bacterial challenge. Vaccine. 2002;20:2278-86 pubmed
    ..Inflammation was not reduced in S. dysgalactiae (6 x His)GapC vaccinates, suggesting that it does not confer cross-species protection. ..

More Information

Publications97

  1. Clancy J, dib Hajj F, Petitpas J, Yuan W. Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae. Antimicrob Agents Chemother. 1997;41:2719-23 pubmed
    ..Its gene has been designated mreA (for macrolide resistance efflux). ..
  2. Brochu D, Vadeboncoeur C. The HPr(Ser) kinase of Streptococcus salivarius: purification, properties, and cloning of the hprK gene. J Bacteriol. 1999;181:709-17 pubmed
    ..salivarius is not stimulated by FDP or other glycolytic intermediates. The enzyme is inhibited by inorganic phosphate, and its Kms for HPr and ATP are 31 microM and 1 mM, respectively. ..
  3. W stfelt M, St lhammar Carlemalm M, Delisse A, Cabezon T, Lindahl G. Identification of a family of streptococcal surface proteins with extremely repetitive structure. J Biol Chem. 1996;271:18892-7 pubmed
    ..We conclude that Rib and alpha are members of a novel family of streptococcal surface proteins with unusual repetitive structure...
  4. Hughes M, Moore J, Lane J, Wilson R, Pribul P, Younes Z, et al. Identification of major outer surface proteins of Streptococcus agalactiae. Infect Immun. 2002;70:1254-9 pubmed
    ..These studies demonstrate the successful application of proteomics as a technique for identifying vaccine candidates...
  5. Gagnon G, Vadeboncoeur C, Gauthier L, Frenette M. Regulation of ptsH and ptsI gene expression in Streptococcus salivarius ATCC 25975. Mol Microbiol. 1995;16:1111-21 pubmed
    ..Studies with a 2-deoxyglucose-resistant spontaneous mutant of S. salivarius (L26) that produces an HPr-EI fusion protein suggest that the regulation of HPr and EI expression involves transcriptional as well as translational mechanisms. ..
  6. Rowe H, Hanson B, Runft D, Lin Q, Firestine S, Neely M. Modification of the CpsA protein reveals a role in alteration of the Streptococcus agalactiae cell envelope. Infect Immun. 2015;83:1497-506 pubmed publisher
    ..Finally, expression of truncated CpsA also led to attenuation of virulence in zebrafish models of infection, to levels below that of a cpsA deletion strain, demonstrating the key role of the extracellular domain in virulence of GBS. ..
  7. Lamy M, Dramsi S, Billo t A, R glier Poupet H, Tazi A, Raymond J, et al. Rapid detection of the "highly virulent" group B Streptococcus ST-17 clone. Microbes Infect. 2006;8:1714-22 pubmed publisher
    ..Using this technique, accurate identification of women and neonates colonized by ST-17 can be readily achieved within less than 2 h...
  8. Khare B, Samal A, Vengadesan K, Rajashankar K, Ma X, Huang I, et al. Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1096-100 pubmed publisher
    ..agalactiae strain 2603V/R. The GBS SrtC1 has been crystallized in three crystal forms and the GBS SrtA has been crystallized in one crystal form. ..
  9. Kuhnert W, Quivey R. Genetic and biochemical characterization of the F-ATPase operon from Streptococcus sanguis 10904. J Bacteriol. 2003;185:1525-33 pubmed
    ..Hybrid enzymes were found to be relatively insensitive to inhibition by dicyclohexylcarbodiimide, indicating loss of productive coupling between the membrane and catalytic subunits. ..
  10. Puopolo K, Hollingshead S, Carey V, Madoff L. Tandem repeat deletion in the alpha C protein of group B streptococcus is recA independent. Infect Immun. 2001;69:5037-45 pubmed
  11. Gase K, Ozegowski J, Malke H. The Streptococcus agalactiae hylB gene encoding hyaluronate lyase: completion of the sequence and expression analysis. Biochim Biophys Acta. 1998;1398:86-98 pubmed
    ..agalactiae 3502 and S. pneumoniae characterized by others but sequence comparisons clearly show that incomplete genes truncated at their 5' ends had been isolated from these two organisms. ..
  12. Reinscheid D, Gottschalk B, Schubert A, Eikmanns B, Chhatwal G. Identification and molecular analysis of PcsB, a protein required for cell wall separation of group B streptococcus. J Bacteriol. 2001;183:1175-83 pubmed publisher
    ..These data suggest a pivotal role of PcsB for cell division and antibiotic tolerance of GBS...
  13. Kong F, Gowan S, Martin D, James G, Gilbert G. Serotype identification of group B streptococci by PCR and sequencing. J Clin Microbiol. 2002;40:216-26 pubmed
    ..The MS identification method is a specific and practical alternative to conventional GBS serotyping and will facilitate epidemiological studies...
  14. Cozzi R, Zerbini F, Assfalg M, D Onofrio M, Biagini M, Martinelli M, et al. Group B Streptococcus pilus sortase regulation: a single mutation in the lid region induces pilin protein polymerization in vitro. FASEB J. 2013;27:3144-54 pubmed publisher
    ..Moreover, biochemical analyses of this recombinant mutant reveal that the lid confers thermodynamic and proteolytic stability to the enzyme. ..
  15. Schormann N, Ayres C, Fry A, Green T, Banerjee S, Ulett G, et al. Crystal Structures of Group B Streptococcus Glyceraldehyde-3-Phosphate Dehydrogenase: Apo-Form, Binary and Ternary Complexes. PLoS ONE. 2016;11:e0165917 pubmed publisher
    ..The structures also reveal at least three surface-exposed areas that differ in amino acid sequence compared to the corresponding areas of human GAPDH. ..
  16. Fischer A, Liljander A, Kaspar H, Muriuki C, Fuxelius H, Bongcam Rudloff E, et al. Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element. Vet Res. 2013;44:86 pubmed publisher
    ..Wound infections and mastitis in camels associated with GBS are widespread and should ideally be treated with antimicrobials other than tetracycline in East Africa. ..
  17. Connolly K, Wojciak J, Clubb R. Site-specific DNA binding using a variation of the double stranded RNA binding motif. Nat Struct Biol. 1998;5:546-50 pubmed
    ..This surface differs from the proposed RNA binding surface in dsRBDs, suggesting that different surfaces on the same protein fold can be used to bind DNA and RNA. ..
  18. Kawabata S, Terao Y, Andoh T, Hamada S. Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii. FEMS Microbiol Lett. 1997;156:211-6 pubmed
    ..The nucleotide binding assay demonstrated that recombinant Sgg bound [32P]GTP but not [32P]ATP, [32P]CTP, or [32P]UTP. These findings indicate that Sgg is a member of the G protein superfamily in the genus Streptococcus. ..
  19. Woo P, Teng J, Lau S, Lum P, Leung K, Wong K, et al. Analysis of a viridans group strain reveals a case of bacteremia due to lancefield group G alpha-hemolytic Streptococcus dysgalactiae subsp equisimilis in a patient with pyomyositis and reactive arthritis. J Clin Microbiol. 2003;41:613-8 pubmed
    ..equisimilis or a novel type of S. dysgalactiae. The present case showed that group G alpha-hemolytic S. dysgalactiae subsp. equisimilis can be associated with serious invasive infection and poststreptococcal sequelae. ..
  20. Stapleton P, Adams V, Pike R, Lucas V, Roberts G, Mullany P, et al. Characterisation of viridans group streptococci with different levels of Tet(M)-mediated tetracycline resistance. Int J Antimicrob Agents. 2004;24:439-43 pubmed
  21. Rajagopal L, Clancy A, Rubens C. A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence. J Biol Chem. 2003;278:14429-41 pubmed publisher
    ..These results suggest that these eukaryotic-type enzymes regulate pyrophosphatase activity and other cellular functions of S. agalactiae...
  22. Erdogan S, Fagan P, Talay S, Rohde M, Ferrieri P, Flores A, et al. Molecular analysis of group B protective surface protein, a new cell surface protective antigen of group B streptococci. Infect Immun. 2002;70:803-11 pubmed
    ..Therefore, BPS protein represents a new R-like protective antigen of GBS...
  23. Del Grosso M, Iannelli F, Messina C, Santagati M, Petrosillo N, Stefani S, et al. Macrolide efflux genes mef(A) and mef(E) are carried by different genetic elements in Streptococcus pneumoniae. J Clin Microbiol. 2002;40:774-8 pubmed
    ..Due to the important different characteristics of the strains carrying mef(A) or mef(E), we suggest that the distinction between the two genes be maintained...
  24. Hamilton A, Popham D, Carl D, Lauth X, Nizet V, Jones A. Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides. Infect Immun. 2006;74:6179-87 pubmed publisher
    ..While the peptidoglycan polymerization and cross-linking activity of PBPs are essential for bacterial survival, our study is the first to identify a role for a PBP in resistance to host AMPs...
  25. Yamamoto Y, Pargade V, Lamberet G, Gaudu P, Thomas F, Texereau J, et al. The Group B Streptococcus NADH oxidase Nox-2 is involved in fatty acid biosynthesis during aerobic growth and contributes to virulence. Mol Microbiol. 2006;62:772-85 pubmed publisher
    ..As the nox2 defect seems only to affect aerobic growth of GBS, its reduced virulence supports the suggestion that aerobic conditions and NADH oxidase activities are relevant to the GBS infection process...
  26. Chaffin D, McKinnon K, Rubens C. CpsK of Streptococcus agalactiae exhibits alpha2,3-sialyltransferase activity in Haemophilus ducreyi. Mol Microbiol. 2002;45:109-22 pubmed
  27. Zhao Z, Kong F, Martinez G, Zeng X, Gottschalk M, Gilbert G. Molecular serotype identification of Streptococcus agalactiae of bovine origin by multiplex PCR-based reverse line blot (mPCR/RLB) hybridization assay. FEMS Microbiol Lett. 2006;263:236-9 pubmed publisher
    ..Our results demonstrate that cps clusters of bovine GBS differ significantly from those of GBS isolates from humans...
  28. Mello L, de Groot B, Li S, Jedrzejas M. Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan. J Biol Chem. 2002;277:36678-88 pubmed publisher
    ..This opening/closing mode also reflects the main conformational difference between the crystal structures of the S. agalactiae and the S. pneumoniae hyaluronate lyases...
  29. Seifert K, Adderson E, Whiting A, Bohnsack J, Crowley P, Brady L. A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae. Microbiology. 2006;152:1029-40 pubmed publisher
    ..These results indicate that the RDP III-3/ST-17 lineage expresses Srr-2 and is highly virulent in an in vivo model of neonatal sepsis...
  30. Jones A, Needham R, Clancy A, Knoll K, Rubens C. Penicillin-binding proteins in Streptococcus agalactiae: a novel mechanism for evasion of immune clearance. Mol Microbiol. 2003;47:247-56 pubmed
  31. Seifert K, McArthur W, Bleiweis A, Brady L. Characterization of group B streptococcal glyceraldehyde-3-phosphate dehydrogenase: surface localization, enzymatic activity, and protein-protein interactions. Can J Microbiol. 2003;49:350-6 pubmed publisher
    ..Enzymatically active GAPDH, capable of binding cytoskeletal and extracellular matrix proteins, is expressed on the surface of GBS...
  32. Cieslewicz M, Chaffin D, Glusman G, Kasper D, Madan A, Rodrigues S, et al. Structural and genetic diversity of group B streptococcus capsular polysaccharides. Infect Immun. 2005;73:3096-103 pubmed publisher
  33. Abbani M, Iwahara M, Clubb R. The structure of the excisionase (Xis) protein from conjugative transposon Tn916 provides insights into the regulation of heterobivalent tyrosine recombinases. J Mol Biol. 2005;347:11-25 pubmed publisher
  34. Franken C, Brandt C, Br ker G, Spellerberg B. ISSag1 in streptococcal strains of human and animal origin. Int J Med Microbiol. 2004;294:247-54 pubmed publisher
    ..This mosaic structure suggests that recombination and horizontal gene transfer events in S. dysgalactiae strains of bovine origin could have played a role in the assembly of the scpB-lmb composite transposon structure...
  35. Del Grosso M, Scotto D Abusco A, Iannelli F, Pozzi G, Pantosti A. Tn2009, a Tn916-like element containing mef(E) in Streptococcus pneumoniae. Antimicrob Agents Chemother. 2004;48:2037-42 pubmed publisher
    ..It is possible to hypothesize that Tn2009 relies on transformation for its spread among clinical strains of S. pneumoniae...
  36. Bohnsack J, Whiting A, Martinez G, Jones N, Adderson E, Detrick S, et al. Serotype III Streptococcus agalactiae from bovine milk and human neonatal infections. Emerg Infect Dis. 2004;10:1412-9 pubmed publisher
    ..These results support the assertion that human and bovine GBS are largely unrelated and provide further insight into the genetic relation between human and bovine GBS...
  37. Spellerberg B, Martin S, Brandt C, L tticken R. The cyl genes of Streptococcus agalactiae are involved in the production of pigment. FEMS Microbiol Lett. 2000;188:125-8 pubmed
    ..These novel genes are cotranscribed with the cyl gene cluster and were designated cylF and cylI. Our data indicate that identical genes participate in the production of S. agalactiae hemolysin and pigment...
  38. Spellerberg B, Pohl B, Haase G, Martin S, Weber Heynemann J, L tticken R. Identification of genetic determinants for the hemolytic activity of Streptococcus agalactiae by ISS1 transposition. J Bacteriol. 1999;181:3212-9 pubmed
    ..agalactiae was confirmed either by targeted mutagenesis with the vector pGh5, complementation studies with pAT28, or analysis of insertion elements in naturally occurring nonhemolytic mutants...
  39. Yamamoto S, Miyake K, Koike Y, Watanabe M, Machida Y, Ohta M, et al. Molecular characterization of type-specific capsular polysaccharide biosynthesis genes of Streptococcus agalactiae type Ia. J Bacteriol. 1999;181:5176-84 pubmed
  40. Wojciak J, Connolly K, Clubb R. NMR structure of the Tn916 integrase-DNA complex. Nat Struct Biol. 1999;6:366-73 pubmed publisher
    ..The DNA in the complex is bent approximately 35 degrees and may, together with potential interactions between bound integrase proteins at directly repeated sites, significantly bend the arms of the transposon...
  41. Spellerberg B, Rozdzinski E, Martin S, Weber Heynemann J, Schnitzler N, L tticken R, et al. Lmb, a protein with similarities to the LraI adhesin family, mediates attachment of Streptococcus agalactiae to human laminin. Infect Immun. 1999;67:871-8 pubmed
    ..These results indicate that Lmb mediates the attachment of S. agalactiae to human laminin, which may be essential for the bacterial colonization of damaged epithelium and translocation of bacteria into the bloodstream...
  42. Mollerach M, L pez R, Garc a E. Characterization of the galU gene of Streptococcus pneumoniae encoding a uridine diphosphoglucose pyrophosphorylase: a gene essential for capsular polysaccharide biosynthesis. J Exp Med. 1998;188:2047-56 pubmed
    ..pyogenes...
  43. Granlund M, Oberg L, Sellin M, Norgren M. Identification of a novel insertion element, IS1548, in group B streptococci, predominantly in strains causing endocarditis. J Infect Dis. 1998;177:967-76 pubmed
    ..IS1548 was present in 9 of 13 GBS isolates from blood in endocarditis patients and in 3 of 22 vaginally colonizing strains...
  44. Provvedi R, Manganelli R, Pozzi G. Characterization of conjugative transposon Tn5251 of Streptococcus pneumoniae. FEMS Microbiol Lett. 1996;135:231-6 pubmed
    ..Conjugal transfer of Tn5251 independent from Tn5253 could not be detected, even if we could show excision and formation of Tn5251 circular intermediates at a level of 5.4 copies per 10(6) chromosomes...
  45. Lachenauer C, Creti R, Michel J, Madoff L. Mosaicism in the alpha-like protein genes of group B streptococci. Proc Natl Acad Sci U S A. 2000;97:9630-5 pubmed
    ..These findings indicate that the alpha-like proteins are encoded by mosaic variants at a single genomic locus and suggest that recombination after horizontal DNA transfer is a means of generating diversity within this protein family...
  46. Brodeur B, Boyer M, Charlebois I, Hamel J, Couture F, Rioux C, et al. Identification of group B streptococcal Sip protein, which elicits cross-protective immunity. Infect Immun. 2000;68:5610-8 pubmed
    ..The data presented in this study suggest that this highly conserved protein induces cross-protective immunity against GBS infections and emphasize its potential as a universal vaccine candidate...
  47. Podbielski A, Blankenstein O, L tticken R. Molecular characterization of the cfb gene encoding group B streptococcal CAMP-factor. Med Microbiol Immunol. 1994;183:239-56 pubmed
    ..Only the full-sized recombinant CAMP-factor was found to exert co-hemolytic activity in a sheep-blood agar assay. This co-hemolytic activity could be inhibited by anti-CAMP antiserum...
  48. Pritzlaff C, Chang J, Kuo S, Tamura G, Rubens C, Nizet V. Genetic basis for the beta-haemolytic/cytolytic activity of group B Streptococcus. Mol Microbiol. 2001;39:236-47 pubmed
    ..coli. We conclude that cylE probably represents the structural gene for the GBS haemolysin/cytolysin, a novel bacterial toxin...
  49. Gay K, Stephens D. Structure and dissemination of a chromosomal insertion element encoding macrolide efflux in Streptococcus pneumoniae. J Infect Dis. 2001;184:56-65 pubmed publisher
    ..In metropolitan Atlanta, macrolide resistance due to mega rapidly increased in S. pneumoniae by clonal expansion and horizontally by transformation...
  50. Li S, Jedrzejas M. Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase. J Biol Chem. 2001;276:41407-16 pubmed publisher
    ..Hyaluronan chain is processively degraded from the reducing end toward the nonreducing end. The unsulfated or 6-sulfated regions of chondroitin sulfate can also be degraded in the same manner as hyaluronan...
  51. R hlmann J, Wittmann Liebold B, J rgens D, Fehrenbach F. Complete amino acid sequence of protein B. FEBS Lett. 1988;235:262-6 pubmed
    ..The protein contains 226 amino acids and has an Mr of 25,263. The sequence was compared with sequences of other Fc-binding proteins and partial sequence homology was found between protein B and the Fc-binding region of protein A...
  52. Rubens C, Heggen L, Kuypers J. IS861, a group B streptococcal insertion sequence related to IS150 and IS3 of Escherichia coli. J Bacteriol. 1989;171:5531-5 pubmed
    ..IS861 is the first insertion sequence identified in GBS. Its role in GBS and the significance of its relationship to the phylogenetically similar insertion sequences typified by IS150 and IS3 of E. coli are unknown...
  53. Stapleton P, Pike R, Mullany P, Lucas V, Roberts G, Rowbury R, et al. Mercuric resistance genes in gram-positive oral bacteria. FEMS Microbiol Lett. 2004;236:213-20 pubmed
    ..Coagulase-negative staphylococci and Streptococcus parasanguis had identical merA genes that represent a new merA variant...
  54. Krishnan V, Gaspar A, Ye N, Mandlik A, Ton That H, Narayana S. An IgG-like domain in the minor pilin GBS52 of Streptococcus agalactiae mediates lung epithelial cell adhesion. Structure. 2007;15:893-903 pubmed publisher
    ..Nonetheless, substantial binding is only observed with N2 domain-conjugated beads. This study presents the structure of a Gram-positive pilin that utilizes a distinct IgG fold variant to mediate pathogen adherence to a specific tissue...
  55. Jiang S, Ishmael N, Dunning Hotopp J, Puliti M, Tissi L, Kumar N, et al. Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity. J Bacteriol. 2008;190:1956-65 pubmed publisher
    ..Such variation is likely to play an important role in strain-specific adaptation of GBS to particular host environments and pathogenic potential in susceptible hosts...
  56. Rantanen M, Lehti L, Rajagopal L, Rubens C, Goldman A. Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion. FEBS J. 2007;274:3128-37 pubmed publisher
    ..This interaction may mimic the binding of a product complex, especially since the motif binding to the active site contains a serine residue aligning remarkably well with the phosphate found in the human STP structure...
  57. Spellerberg B, Rozdzinski E, Martin S, Weber Heynemann J, L tticken R. rgf encodes a novel two-component signal transduction system of Streptococcus agalactiae. Infect Immun. 2002;70:2434-40 pubmed
    ..Based on these results, we hypothesize that rgf regulates the expression of bacterial cell surface components...
  58. Bohnsack J, Whiting A, Bradford R, Van Frank B, Takahashi S, Adderson E. Long-range mapping of the Streptococcus agalactiae phylogenetic lineage restriction digest pattern type III-3 reveals clustering of virulence genes. Infect Immun. 2002;70:134-9 pubmed
    ..These findings suggest that the genetic variation that distinguishes the RDP type III-3 strains from other serotype III strains occurs largely within localized areas of the genome containing known or putative virulence genes...
  59. Santi I, Grifantini R, Jiang S, Brettoni C, Grandi G, Wessels M, et al. CsrRS regulates group B Streptococcus virulence gene expression in response to environmental pH: a new perspective on vaccine development. J Bacteriol. 2009;191:5387-97 pubmed publisher
    ..0 induced opsonophagocytic killing of GBS in immune serum highlights the importance of pH regulation in the protective efficacy of specific antibodies to surface-exposed GBS proteins...
  60. Banks D, Porcella S, Barbian K, Martin J, Musser J. Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phylogenetically diverse clones of group A Streptococcus. J Infect Dis. 2003;188:1898-908 pubmed publisher
    ..Together, these data provide new information about the molecular genetic basis of macrolide resistance and dissemination in GAS strains...
  61. Chaffin D, Beres S, Yim H, Rubens C. The serotype of type Ia and III group B streptococci is determined by the polymerase gene within the polycistronic capsule operon. J Bacteriol. 2000;182:4466-77 pubmed
    ..Additionally, these findings suggested that a single gene can confer serotype specificity in organisms that produce complex polysaccharides...
  62. Jones A, Needham R, Rubens C. The Delta subunit of RNA polymerase is required for virulence of Streptococcus agalactiae. Infect Immun. 2003;71:4011-7 pubmed
    ..Our data represent the first report of a phenotype relevant to virulence for rpoE mutants...
  63. Nair S, Poyart C, Beretti J, Veiga Fernandes H, Berche P, Trieu Cuot P. Role of the Streptococcus agalactiae ClpP serine protease in heat-induced stress defence and growth arrest. Microbiology. 2003;149:407-17 pubmed publisher
    ..Even though ClpP plays a minor role in the virulence of S. agalactiae in a murine infection model, the data presented here point to the importance of ClpP in oxidative stress defence in preventing heat-induced cell alterations...
  64. Harris T, Shelver D, Bohnsack J, Rubens C. A novel streptococcal surface protease promotes virulence, resistance to opsonophagocytosis, and cleavage of human fibrinogen. J Clin Invest. 2003;111:61-70 pubmed publisher
    ..Taken together, the results suggest that cleavage of fibrinogen by CspA may increase the lethality of GBS infection, potentially by protecting the bacterium from opsonophagocytic killing...
  65. Hung W, Tsai J, Hsueh P, Chia J, Teng L. Species identification of mutans streptococci by groESL gene sequence. J Med Microbiol. 2005;54:857-62 pubmed publisher
  66. Lottenberg R, Broder C, Boyle M, Kain S, Schroeder B, Curtiss R. Cloning, sequence analysis, and expression in Escherichia coli of a streptococcal plasmin receptor. J Bacteriol. 1992;174:5204-10 pubmed
    ..The deduced amino acid sequence for the plasmin receptor protein revealed significant similarity (39 to 54% identical amino acid residues) to glyceraldehyde 3-phosphate dehydrogenases...
  67. Dammel C, Noller H. Suppression of a cold-sensitive mutation in 16S rRNA by overexpression of a novel ribosome-binding factor, RbfA. Genes Dev. 1995;9:626-37 pubmed
  68. Rathsam C, Giffard P, Jacques N. The cell-bound fructosyltransferase of Streptococcus salivarius: the carboxyl terminus specifies attachment in a Streptococcus gordonii model system. J Bacteriol. 1993;175:4520-7 pubmed
    ..This cell-bound activity was released in the presence of sucrose, suggesting that the mode of attachment and release of the S. salivarius FTF in S. gordonii was similar to that in its native host...
  69. Yoshida Y, Ganguly S, Bush C, Cisar J. Molecular basis of L-rhamnose branch formation in streptococcal coaggregation receptor polysaccharides. J Bacteriol. 2006;188:4125-30 pubmed publisher
    ..gordonii 38 and wefH in S. oralis 34. These genes were distinguished by the unique ability of WefC to act on the branched acceptor formed by the action of WefB...
  70. Asanuma N, Hino T. Molecular characterization of HPr and related enzymes, and regulation of HPr phosphorylation in the ruminal bacterium Streptococcus bovis. Arch Microbiol. 2003;179:205-13 pubmed publisher
    ..Thus, it is conceivable that the ratio of HPr-[Ser-P] to HPr-[His-P] is regulated by the bifunctional activity of HPr kinase in response to intracellular P(i) concentration...
  71. Tsai J, Hsueh P, Chen H, Tseng S, Chen P, Teng L. The erm(T) gene is flanked by IS1216V in inducible erythromycin-resistant Streptococcus gallolyticus subsp. pasteurianus. Antimicrob Agents Chemother. 2005;49:4347-50 pubmed publisher
    ..pasteurianus (formerly S. bovis biotype II.2) isolates. In all isolates, the erm(T) genes were flanked by two IS1216V-like elements with the same polarity and were found to be inserted in the chromosome...
  72. Yoshida Y, Ganguly S, Bush C, Cisar J. Carbohydrate engineering of the recognition motifs in streptococcal co-aggregation receptor polysaccharides. Mol Microbiol. 2005;58:244-56 pubmed publisher
    ..The reactions of these genetically modified polysaccharides as antigens and receptors provide further insight into the structural basis of RPS function...
  73. Morona J, Morona R, Paton J. Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types belonging to serogroup 19. J Bacteriol. 1999;181:5355-64 pubmed
  74. Burne R, Wen Z, Chen Y, Penders J. Regulation of expression of the fructan hydrolase gene of Streptococcus mutans GS-5 by induction and carbon catabolite repression. J Bacteriol. 1999;181:2863-71 pubmed
  75. Maeda K, Nagata H, Nonaka A, Kataoka K, Tanaka M, Shizukuishi S. Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae. Microbes Infect. 2004;6:1163-70 pubmed publisher
    ..These results suggest that GAPDHs of various plaque-forming streptococci may be involved in their attachment to P. gingivalis fimbriae and that they may contribute to P. gingivalis colonization...
  76. Brassard J, Gottschalk M, Quessy S. Cloning and purification of the Streptococcus suis serotype 2 glyceraldehyde-3-phosphate dehydrogenase and its involvement as an adhesin. Vet Microbiol. 2004;102:87-94 pubmed publisher
    ..suis in the (His)6GAPDH pre-incubated rings compared to the non-incubated rings. The GAPDH protein of S. suis seems to be involved in the first steps of the bacterial adhesion to host cells...
  77. Tamura G, Nittayajarn A, Schoentag D. A glutamine transport gene, glnQ, is required for fibronectin adherence and virulence of group B streptococci. Infect Immun. 2002;70:2877-85 pubmed
    ..We speculate that glnQ may regulate expression of fibronectin adhesins by affecting cytoplasmic glutamine levels and that regulation may be posttranscriptional...
  78. Hong K. Identification and characterization of a novel fibronectin-binding protein gene from Streptococcus equi subspecies zooepidemicus strain VTU211. FEMS Immunol Med Microbiol. 2005;45:231-7 pubmed publisher
    ..Purified FNZ2(2-4) protein was also shown to display collagen-binding activity to collagen-coated microtiter wells. These results show that recombinant FNZ2 has fibronectin- and collagen-binding activities...
  79. Kimoto H, Fujii Y, Yokota Y, Taketo A. Molecular characterization of NADase-streptolysin O operon of hemolytic streptococci. Biochim Biophys Acta. 2005;1681:134-49 pubmed publisher
    ..Additional results suggest that NADase, synthesized as precursor with feeble activity, is activated by removing the carboxyl terminal region during or after secretion into culture medium...
  80. Maeda K, Nagata H, Yamamoto Y, Tanaka M, Tanaka J, Minamino N, et al. Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus oralis functions as a coadhesin for Porphyromonas gingivalis major fimbriae. Infect Immun. 2004;72:1341-8 pubmed
    ..gingivalis fimbriae. In addition, considering the high degree of homology of the GAPDHs of various bacteria, those of other plaque-forming bacteria also may contribute to the colonization of P. gingivalis...
  81. Lucchini S, Sidoti J, Br ssow H. Broad-range bacteriophage resistance in Streptococcus thermophilus by insertional mutagenesis. Virology. 2000;275:267-77 pubmed publisher
  82. Morona J, Morona R, Paton J. Analysis of the 5' portion of the type 19A capsule locus identifies two classes of cpsC, cpsD, and cpsE genes in Streptococcus pneumoniae. J Bacteriol. 1999;181:3599-605 pubmed
    ..Whereas members within one class are greater than 95% identical to each other, the DNA sequence identity between the two classes is only approximately 70%...
  83. Poyart C, Quesne G, Coulon S, Berche P, Trieu Cuot P. Identification of streptococci to species level by sequencing the gene encoding the manganese-dependent superoxide dismutase. J Clin Microbiol. 1998;36:41-7 pubmed
    ..We propose this method for the characterization of strains that cannot be assigned to a species on the basis of their conventional phenotypic reactions...
  84. Jayaraman G, Penders J, Burne R. Transcriptional analysis of the Streptococcus mutans hrcA, grpE and dnaK genes and regulation of expression in response to heat shock and environmental acidification. Mol Microbiol. 1997;25:329-41 pubmed
  85. Morona J, Morona R, Paton J. Characterization of the locus encoding the Streptococcus pneumoniae type 19F capsular polysaccharide biosynthetic pathway. Mol Microbiol. 1997;23:751-63 pubmed
    ..pneumoniae serotypes/groups tested. The region from cps19fG to cps19fK was found only in members of serogroup 19, and, within this, cps19fl was unique to type 19F...
  86. Poyart C, Berche P, Trieu Cuot P. Characterization of superoxide dismutase genes from gram-positive bacteria by polymerase chain reaction using degenerate primers. FEMS Microbiol Lett. 1995;131:41-5 pubmed
    ..The method described in this study provides a means for easy recovery of sod genes and the construction of sod mutants of various Gram-positive pathogens...
  87. Pancholi V, Fischetti V. A major surface protein on group A streptococci is a glyceraldehyde-3-phosphate-dehydrogenase with multiple binding activity. J Exp Med. 1992;176:415-26 pubmed
    ..The multiple binding capacity of the SDH in conjunction with its GAPDH activity may play a role in the colonization, internalization, and the subsequent proliferation of group A streptococci...
  88. Burne R, Penders J. Characterization of the Streptococcus mutans GS-5 fruA gene encoding exo-beta-D-fructosidase. Infect Immun. 1992;60:4621-32 pubmed
    ..The data begin to define functional domains of the FruA protein and potential regulatory sites for induction, repression, growth rate control, and posttranslational localization of this multifunctional enzyme...