Staphylococcus epidermidis ATCC 12228



Top Publications

  1. Malik S, Coombs G, O Brien F, Peng H, Barton M. Molecular typing of methicillin-resistant staphylococci isolated from cats and dogs. J Antimicrob Chemother. 2006;58:428-31 pubmed publisher
    ..MRS isolates from cats and dogs demonstrate a similar diversity of SCCmec types to those found in human staphylococci and ST239-MRSA-III, a widely dispersed strain in human hospitals, was identified in diseased dogs...
  2. Heilmann C, Hussain M, Peters G, Gotz F. Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface. Mol Microbiol. 1997;24:1013-24 pubmed
    ..Our findings provide evidence for a new function of an autolysin (AtlE) in mediating the attachment of bacterial cells to a polymer surface, representing the prerequisite for biofilm formation. ..
  3. Otto M, Sussmuth R, Jung G, Gotz F. Structure of the pheromone peptide of the Staphylococcus epidermidis agr system. FEBS Lett. 1998;424:89-94 pubmed
    ..The peptide was active at nanomolar concentrations. The N-terminus of the peptide pheromone, which is encoded as part of a protein precursor, proved to be crucial for biological activity. ..
  4. Cascioferro S, Parrino B, Petri G, Cusimano M, Schillaci D, Di Sarno V, et al. 2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors. Eur J Med Chem. 2019;167:200-210 pubmed publisher
    ..aureus ATCC 6538 and Staphylococcus epidermidis ATCC 12228, and the Gram-negative strains Pseudomonas aeruginosa ATCC 15442 and Escherichia coli ATCC 25922...
  5. Dragostin O, Lupascu F, Vasile C, Mareş M, Năstasă V, Moraru R, et al. Synthesis and biological evaluation of new 2-azetidinones with sulfonamide structures. Molecules. 2013;18:4140-57 pubmed publisher
    ..activities of these compounds against Gram positive (Staphylococcus aureus ATCC 6583, Staphylococcus epidermidis ATCC 12228, Enterococcus faecalis ATCC 25912) and Gram negative (Klebsiella pneumoniae CIP 53153, Proteus ..
  6. Asadipour A, Moshafi M, Khosravani L, Moghimi S, Amou E, Firoozpour L, et al. N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluation. Daru. 2018;26:199-207 pubmed publisher
    ..activities against Gram-positive [Staphylococcus aureus ATCC 6538p, Micrococcus luteus, ATCC 1110, Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633] and Gram-negative [Escherichia coli ATCC 8739, Klebsiella ..
  7. Kalinowska Lis U, Felczak A, Chęcińska L, Zawadzka K, Patyna E, Lisowska K, et al. Synthesis, characterization and antimicrobial activity of water-soluble silver(i) complexes of metronidazole drug and selected counter-ions. Dalton Trans. 2015;44:8178-89 pubmed publisher
    ..activities of the complexes against two Gram-positive strains: Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, three Gram-negative strains: Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922, ..
  8. Kirker K, Fisher S, James G. Potency and penetration of telavancin in staphylococcal biofilms. Int J Antimicrob Agents. 2015;46:451-5 pubmed publisher
    ..aureus ATCC 700698 and meticillin-sensitive Staphylococcus epidermidis ATCC 12228, were grown and treated in drip-flow reactors to determine log reductions due to telavancin ..
  9. Pathan N, Parvez A, Bader A, Shaheen U, Hadda T. Synthesis, characterization, crystal structure determination and biological screening of novel N-1 and C5 alkyl substituted scaffolds of pyrimidine. Eur J Med Chem. 2015;103:594-9 pubmed publisher
    ..strain: Staphylococcus aureus ATCC 6538P, Salmonella abony NCTC 6017: Escherichia coli ATCC 8739, Staphylococcus epidermidis ATCC 12228. Among all compounds evaluated the molecule 2c and (2g-j) exhibit the most pronounced ..

More Information


  1. Stavropoulou D, Van Reckem E, De Smet S, De Vuyst L, Leroy F. The narrowing down of inoculated communities of coagulase-negative staphylococci in fermented meat models is modulated by temperature and pH. Int J Food Microbiol. 2018;274:52-59 pubmed publisher
    ..carnosus 833, Staphylococcus epidermidis ATCC 12228, Staphylococcus equorum DFL-S19, and Staphylococcus saprophyticus FPS1)...
  2. Auranwiwat C, Trisuwan K, Saiai A, Pyne S, Ritthiwigrom T. Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa. Fitoterapia. 2014;98:179-83 pubmed publisher
    ..Escherichia coli TISTR 780, Pseudomonas aeruginosa TISTR 781, Salmonella typhimurium TISTR 292 and Staphylococcus epidermidis ATCC 12228. α-Mangostin showed potent activity (MIC 0...
  3. Abuelizz H, El Dib R, Marzouk M, Al Salahi R. In vitro evaluation of new 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives as antimicrobial agents. Microb Pathog. 2018;117:60-67 pubmed publisher
    ..The current study showed that some benzo[g]traizoloquinazolines displayed remarkable antimicrobial activity and could be used as template for further design of potent antimicrobial agent. ..
  4. França J, Queiroz M, do Amaral B, Simas N, da Silva N, Leal I. Distinct growth and extractive methods of Acmellaoleracea (L.) R.K. Jansen rising different concentrations of spilanthol: An important bioactive compound in human dietary. Food Res Int. 2016;89:781-789 pubmed publisher
    ..The antibacterial assay presented a negative result using in vitro samples and bacteria inhibition with field samples against Staphylococcus aureus (ATCC 29213) and Staphylococcus epidermidis (ATCC 12228) standard strains. ..
  5. Souza A, Costa A, Campos D, Batista A, Sales G, Nogueira N, et al. Lipid transfer protein isolated from noni seeds displays antibacterial activity in vitro and improves survival in lethal sepsis induced by CLP in mice. Biochimie. 2018;149:9-17 pubmed publisher
    ..In conclusion, McLTP1 could be exploited for its antimicrobial properties, and can be considered a potential therapeutic candidate for the management of clinical sepsis. ..
  6. Xiang K, Li Y, FORD W, Land W, Schaffer J, Congdon R, et al. Automated analysis of food-borne pathogens using a novel microbial cell culture, sensing and classification system. Analyst. 2016;141:1472-82 pubmed publisher
    ..85.4% accuracy range was recorded for unknown samples, and within a shorter time period than the industry standard of 24 hours. ..
  7. Masadeh M, Alzoubi K, Al Azzam S, Khabour O, Al Buhairan A. Ciprofloxacin-Induced Antibacterial Activity Is Atteneuated by Pretreatment with Antioxidant Agents. Pathogens. 2016;5: pubmed publisher
    ..Escherichia coli ATCC 35218, Staphylococcus aureus ATCC29213, Pseudomonas aeruginosa ATCC 9027, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumannii ATCC 17978, Proteus mirabilis ATCC 12459, Klebsiella pneumoniae ATCC ..
  8. Shakhatreh M, Jacob J, Hussein E, Masadeh M, Obeidat S, Juhmani A, et al. Microbiological analysis, antimicrobial activity, and heavy-metals content of Jordanian Ma'in hot-springs water. J Infect Public Health. 2017;10:789-793 pubmed publisher
    ..Nevertheless, MHSW was found to be active against five standard bacterial strains, namely, Staphylococcus epidermidis ATCC 12228 (inhibition zone: 20mm), Staphylococcus aureus ATCC 29213 (inhibition zone: 19mm), Micrococcus ..
  9. Rezvani Amin Z, Khashyarmanesh Z, Fazly Bazzaz B. Different behavior of Staphylococcus epidermidis in intracellular biosynthesis of silver and cadmium sulfide nanoparticles: more stability and lower toxicity of extracted nanoparticles. World J Microbiol Biotechnol. 2016;32:140 pubmed publisher
    ..CdS-NPs indicated no toxicity in in vitro assays. Biosynthetic nanoparticles as product of the detoxification pathway may be safer and more stable for biosensors. ..
  10. Curbete M, Salgado H. Rapid turbidimetric assay for quantification of fusidic acid in a dermatological cream. Talanta. 2016;153:51-6 pubmed publisher
    ..25 to 2.25?gmL(-1). This method is an alternative to the diffusion agar assay currently employed to quantify fusidic acid in dermatological cream, since it is sensitive, fast, and more economical. ..
  11. Gonçalves R, da Silva D, Signini R, Naves P. Inhibition of bacterial biofilms by carboxymethyl chitosan combined with silver, zinc and copper salts. Int J Biol Macromol. 2017;105:385-392 pubmed publisher
    ..nitrate, copper sulfate and zinc sulfate on biofilm formation by Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Kocuria rhizophila ATCC 9341, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 25312, and ..
  12. de Almeida A, de Oliveira B, de Castro P, de Mendonça C, Furtado R, Nicolella H, et al. Lipophilic gold(I) complexes with 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione moieties: synthesis and their cytotoxic and antimicrobial activities. Biometals. 2017;30:841-857 pubmed publisher
    ..activity was evaluated against Gram-positive bacteria Staphylococcus aureus ATCC 25213, Staphylococcus epidermidis ATCC 12228 and Gram-negative bacteria Escherichia coli ATCC 11229 and Pseudomonas aeruginosa ATCC 27853 and ..
  13. MacLea K, Trachtenberg A. Complete Genome Sequence of Staphylococcus epidermidis ATCC 12228 Chromosome and Plasmids, Generated by Long-Read Sequencing. Genome Announc. 2017;5: pubmed publisher
    ..Some differences from the previously generated short-read sequence of this nonpathogenic and non-biofilm-forming strain were noted. The assembly size was 2,570,371 bp with a total G+C% content of 32.08%. ..
  14. Wilke M, Hills T, Zhang H, Chambers H, Strynadka N. Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus. J Biol Chem. 2004;279:47278-87 pubmed publisher
  15. Voladri R, Kernodle D. Characterization of a chromosomal gene encoding type B beta-lactamase in phage group II isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 1998;42:3163-8 pubmed
    ..The type B gene resides on the chromosome and has a sequence that, when compared to the sequences of the other staphylococcal beta-lactamases, corresponds well with its kinetic properties...
  16. Hussain A, Rather M, Shah A, Bhat Z, Shah A, Ahmad Z, et al. Antituberculotic activity of actinobacteria isolated from the rare habitats. Lett Appl Microbiol. 2017;65:256-264 pubmed publisher
  17. Drancourt M, Raoult D. rpoB gene sequence-based identification of Staphylococcus species. J Clin Microbiol. 2002;40:1333-8 pubmed
    ..We propose partial sequencing of the rpoB gene as a new tool for the accurate identification of Staphylococcus isolates...
  18. Barri re C, Br ckner R, Talon R. Characterization of the single superoxide dismutase of Staphylococcus xylosus. Appl Environ Microbiol. 2001;67:4096-104 pubmed
    ..In addition, the mutant was sensitive to hyperbaric oxygen and to paraquat. Therefore, sod plays an important role in the protection of S. xylosus from oxidative stress...
  19. Paulsen I, Brown M, Skurray R. Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system. J Bacteriol. 1998;180:3477-9 pubmed
  20. Zhu T, Lou Q, Wu Y, Hu J, Yu F, Qu D. Impact of the Staphylococcus epidermidis LytSR two-component regulatory system on murein hydrolase activity, pyruvate utilization and global transcriptional profile. BMC Microbiol. 2010;10:287 pubmed publisher
    ..Based on the microarray data, it appears that lytSR inactivation induces a stringent response. In addition, LytSR may indirectly enhance biofilm formation by altering the metabolic status of the bacteria...
  21. Tegmark K, Morfeldt E, Arvidson S. Regulation of agr-dependent virulence genes in Staphylococcus aureus by RNAIII from coagulase-negative staphylococci. J Bacteriol. 1998;180:3181-6 pubmed
    ..By creating S. epidermidis-S. aureus RNAIII hybrids, we could also show that both the 5' and 3' halves of the RNAIII molecule are involved in the transcriptional regulation of alpha-toxin and serine protease mRNAs in S. aureus...
  22. Nilsson M, Frykberg L, Flock J, Pei L, Lindberg M, Guss B. A fibrinogen-binding protein of Staphylococcus epidermidis. Infect Immun. 1998;66:2666-73 pubmed
    ..Sequence comparisons with earlier known proteins revealed that this protein is related to an Fg-binding protein of Staphylococcus aureus called clumping factor...
  23. Haroche J, Allignet J, El Solh N. Tn5406, a new staphylococcal transposon conferring resistance to streptogramin a and related compounds including dalfopristin. Antimicrob Agents Chemother. 2002;46:2337-43 pubmed
    ..To our knowledge, a transposon conferring resistance to streptogramin A and related compounds has not been previously described...
  24. Sugai M, Fujiwara T, Ohta K, Komatsuzawa H, Ohara M, Suginaka H. epr, which encodes glycylglycine endopeptidase resistance, is homologous to femAB and affects serine content of peptidoglycan cross bridges in Staphylococcus capitis and Staphylococcus aureus. J Bacteriol. 1997;179:4311-8 pubmed
    ..These results suggest that epr and femAB belong to the protein family involved in adding amino acids to the pentapeptide peptidoglycan precursor and that epr is involved in the addition of serine to the pentapeptide. ..
  25. Han C, Hu T, Wu D, Qu S, Zhou J, Ding J, et al. X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis. FEBS J. 2009;276:1125-39 pubmed publisher
    ..Thus, a 'closing' process might occur upon NADP binding to bring the cofactor close to the substrate for catalysis...
  26. Rosenstein R, Peschel A, Wieland B, G tz F. Expression and regulation of the antimonite, arsenite, and arsenate resistance operon of Staphylococcus xylosus plasmid pSX267. J Bacteriol. 1992;174:3676-83 pubmed
    ..The three ars genes conferred arsenite resistance in E. coli and arsenite as well as arsenate resistance in Bacillus subtilis...
  27. Bronstein J, Olson S, LeVier K, Tomilo M, Weber P. Purification and characterization of recombinant Staphylococcus haemolyticus DNA gyrase and topoisomerase IV expressed in Escherichia coli. Antimicrob Agents Chemother. 2004;48:2708-11 pubmed
    ..This represents the first description of a method for isolating type II topoisomerases of a coagulase-negative staphylococcal species...
  28. Cockayne A, Hill P, Powell N, Bishop K, Sims C, Williams P. Molecular cloning of a 32-kilodalton lipoprotein component of a novel iron-regulated Staphylococcus epidermidis ABC transporter. Infect Immun. 1998;66:3767-74 pubmed
    ..Although the solute specificity of this novel transporter has not yet been determined, we speculate that it may be involved in either siderophore- or transferrin-mediated iron uptake in S. epidermidis...
  29. Poyart C, Quesne G, Boumaila C, Trieu Cuot P. Rapid and accurate species-level identification of coagulase-negative staphylococci by using the sodA gene as a target. J Clin Microbiol. 2001;39:4296-301 pubmed publisher
    ..The sodA sequence polymorphisms observed with staphylococcal species offer good opportunities for the development of assays based on DNA chip technologies...
  30. Pintens V, Massonet C, Merckx R, Vandecasteele S, Peetermans W, Knobloch J, et al. The role of sigmaB in persistence of Staphylococcus epidermidis foreign body infection. Microbiology. 2008;154:2827-36 pubmed publisher
  31. Meens J, Klose M, Freudl R. The Staphylococcus carnosus secE gene: cloning, nucleotide sequence, and functional characterization in Escherichia coli secE mutant strains. FEMS Microbiol Lett. 1994;117:113-9 pubmed
    ..coli SecE protein in two different secE mutants. These results strongly suggest that the identified secE gene encodes an important component of the S. carnosus protein export apparatus. ..
  32. Paulsen I, Gillespie M, Littlejohn T, Hanvivatvong O, Rowland S, Dyke K, et al. Characterisation of sin, a potential recombinase-encoding gene from Staphylococcus aureus. Gene. 1994;141:109-14 pubmed
    ..A region of dyad symmetry located upstream from sin on pSK1 and pI9789 was identified as the site of insertions of Tn552 and Tn4002 in separate isolates...
  33. Knobloch J, Bartscht K, Sabottke A, Rohde H, Feucht H, Mack D. Biofilm formation by Staphylococcus epidermidis depends on functional RsbU, an activator of the sigB operon: differential activation mechanisms due to ethanol and salt stress. J Bacteriol. 2001;183:2624-33 pubmed publisher
    ..Obviously, different mechanisms are operative in the regulation of PIA expression in stationary phase and under stress induced by salt or ethanol...
  34. Washburn R, Marra A, Bryant A, Rosenberg M, Gentry D. rho is not essential for viability or virulence in Staphylococcus aureus. Antimicrob Agents Chemother. 2001;45:1099-103 pubmed publisher
    ..aureus Rho. Our results explain the lack of activity of bicyclomycin against many gram-positive bacteria and raise the possibility that the essentiality of rho may be the exception rather than the rule...
  35. Lang S, Livesley M, Lambert P, Littler W, Elliott T. Identification of a novel antigen from Staphylococcus epidermidis. FEMS Immunol Med Microbiol. 2000;29:213-20 pubmed
    ..The expression of SsaA during episodes of S. epidermidis endocarditis suggests a virulence role specific to the pathogenesis of this infectious disease...
  36. Qin Z, Zhang J, Xu B, Chen L, Wu Y, Yang X, et al. Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections. BMC Microbiol. 2006;6:96 pubmed publisher
    ..The structure-based virtual screening (SBVS) technology can be widely used in screening potential inhibitors of other bacterial TCSs, since it is more rapid and efficacious than traditional screening technology...
  37. Staedtler P, Hoenig S, Frank R, Withers S, Hengstenberg W. Identification of the active-site nucleophile in 6-phospho-beta-galactosidase from Staphylococcus aureus by labelling with synthetic inhibitors. Eur J Biochem. 1995;232:658-63 pubmed
    ..It was shown to be identical to an authentic, synthetic sample. From this, it is evident that E375 is the active-site nucleophile of 6-phospho-galactosidase, consistent with previous findings for enzymes in this family. ..
  38. Breidt F, Stewart G. Nucleotide and deduced amino acid sequences of the Staphylococcus aureus phospho-beta-galactosidase gene. Appl Environ Microbiol. 1987;53:969-73 pubmed
    ..The protein product of this gene consisted of 470 amino acids, giving a molecular weight of 54,557. This gene appears to be transcribed as the terminal sequence on a polycistronic message. ..
  39. Rowland S, Dyke K. Tn552, a novel transposable element from Staphylococcus aureus. Mol Microbiol. 1990;4:961-75 pubmed
    ..The latter are homologous with the beta-lactamase gene repressor and co-inducer of Bacillus licheniformis. Interestingly, the order of the regulatory genes is reversed in S. aureus compared with Bacillus licheniformis...
  40. Noto M, Archer G. A subset of Staphylococcus aureus strains harboring staphylococcal cassette chromosome mec (SCCmec) type IV is deficient in CcrAB-mediated SCCmec excision. Antimicrob Agents Chemother. 2006;50:2782-8 pubmed publisher
    ..Acquisition of this mobile element, containing a known virulence gene, appears to have stabilized the chromosomal integration of the methicillin resistance gene in these strains...
  41. Alborn W, Hoskins J, Unal S, Flokowitsch J, Hayes C, Dotzlaf J, et al. Cloning and characterization of femA and femB from Staphylococcus epidermidis. Gene. 1996;180:177-81 pubmed
    ..Recombinant FEMA, produced in Escherichia coli (Ec), was purified to near homogeneity. Identity of the purified protein was verified by N-terminal amino acid (aa) sequence analysis. ..
  42. Van Wamel W, van Rossum G, Verhoef J, Vandenbroucke Grauls C, Fluit A. Cloning and characterization of an accessory gene regulator (agr)-like locus from Staphylococcus epidermidis. FEMS Microbiol Lett. 1998;163:1-9 pubmed
    ..epidermidis A097, which showed a delayed agr-response, revealed a truncated AgrC lacking the histidine kinase domain. These data indicate that an agr-like locus is active in S. epidermidis during the post-exponential phase...
  43. Henze U, Roos M, Berger Bachi B. Effects of penicillin-binding protein 4 overproduction in Staphylococcus aureus. Microb Drug Resist. 1996;2:193-9 pubmed
    ..This was linked to morphological changes in the appearance of the cells, which were surrounded by a very thick and fuzzy cell wall. ..
  44. Kuroda M, Kuwahara Arai K, Hiramatsu K. Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method. Biochem Biophys Res Commun. 2000;269:485-90 pubmed publisher
    ..aureus. Presumed increased uptake of fructose and altered fatty acid metabolism may also contribute to vancomycin resistance by supplying more precursor metabolites for cell-wall synthesis...
  45. Ko T, Tseng S, Lai S, Chen S, Guan H, Shin Yang C, et al. SH3-like motif-containing C-terminal domain of staphylococcal teichoic acid transporter suggests possible function. Proteins. 2016;84:1328-32 pubmed publisher
    ..Proteins 2016; 84:1328-1332. © 2016 Wiley Periodicals, Inc. ..
  46. Henze U, Berger Bachi B. Staphylococcus aureus penicillin-binding protein 4 and intrinsic beta-lactam resistance. Antimicrob Agents Chemother. 1995;39:2415-22 pubmed
    ..The abcA-pbp4-tagD gene cluster was located in the SmaI-D fragment in the S. aureus 8325 chromosome in close proximity to the RNA polymerase gene rpoB...
  47. Dale G, Broger C, Hartman P, Langen H, Page M, Then R, et al. Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?. J Bacteriol. 1995;177:2965-70 pubmed
    ..Site-directed mutagenesis and kinetic analysis of the purified enzymes suggest that a single Phe-->Tyr change at position 98 is the major determinant of trimethoprim resistance...
  48. Rowland S, Dyke K. Characterization of the staphylococcal beta-lactamase transposon Tn552. EMBO J. 1989;8:2761-73 pubmed
  49. Kohlbrecher D, Eisermann R, Hengstenberg W. Staphylococcal phosphoenolpyruvate-dependent phosphotransferase system: molecular cloning and nucleotide sequence of the Staphylococcus carnosus ptsI gene and expression and complementation studies of the gene product. J Bacteriol. 1992;174:2208-14 pubmed
    ..coli ptsI mutant JLT2 were carried out. The generation times and interaction between enzyme I with histidine-containing protein from gram-positive and gram-negative bacteria were measured in a phosphoryl group transfer test. ..
  50. Kaito C, Kurokawa K, Hossain M, Akimitsu N, Sekimizu K. Isolation and characterization of temperature-sensitive mutants of the Staphylococcus aureus dnaC gene. FEMS Microbiol Lett. 2002;210:157-64 pubmed
    ..The number of viable mutant cells decreased at a non-permissive temperature, suggesting that S. aureus DnaC helicase is a promising target for antibiotics providing bactericidal effects. ..
  51. McCrea K, Hartford O, Davis S, Eidhin D, Lina G, Speziale P, et al. The serine-aspartate repeat (Sdr) protein family in Staphylococcus epidermidis. Microbiology. 2000;146 ( Pt 7):1535-46 pubmed publisher
    ..Antisera from 16 patients who had recovered from S. epidermidis infections contained antibodies that reacted with recombinant A regions of SdrG and SdrH, suggesting that these proteins can be expressed during infection...
  52. Longshaw C, Farrell A, Wright J, Holland K. Identification of a second lipase gene, gehD, in Staphylococcus epidermidis: comparison of sequence with those of other staphylococcal lipases. Microbiology. 2000;146 ( Pt 6):1419-27 pubmed publisher
    ..epidermidis may be more closely related to those of Staphylococcus aureus than to each other...
  53. Hermans K, De Herdt P, Baele M, Devriese L, Haesebrouck F. Sequence analysis of a RAPD band differentiating high and low virulence Staphylococcus aureus strains from rabbits. Vet Microbiol. 2001;82:61-7 pubmed
    ..The single nucleotide mutation does not affect the amino acid sequence of the protein it encodes for...
  54. Barri re C, Centeno D, Lebert A, Leroy S trin S, Berdagu J, Talon R. Roles of superoxide dismutase and catalase of Staphylococcus xylosus in the inhibition of linoleic acid oxidation. FEMS Microbiol Lett. 2001;201:181-5 pubmed
    ..However, the katA mutant, and especially the sod mutant, had less antioxidant capacity than the S. xylosus wild-type strain. Thus both catalase and SOD of S. xylosus contributed to the inhibition of lipid oxidation...
  55. Dubin G, Chmiel D, Mak P, Rakwalska M, Rzychon M, Dubin A. Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis. Biol Chem. 2001;382:1575-82 pubmed publisher
    ..Moreover, the protease was capable of inactivating, by limited proteolysis, both alpha-1-antitrypsin and HMW-kininogen, but neither alpha-1-antichymotrypsin nor antithrombin III...
  56. Kalbitzer H, Görler A, Li H, Dubovskii P, Hengstenberg W, Kowolik C, et al. 15N and 1H NMR study of histidine containing protein (HPr) from Staphylococcus carnosus at high pressure. Protein Sci. 2000;9:693-703 pubmed
    ..It could represent some kind of anchoring point of the active center loop that holds it in the right place in space, whereas other parts of the loop adapt themselves to changing external conditions. ..
  57. Oliveira D, Tomasz A, de Lencastre H. The evolution of pandemic clones of methicillin-resistant Staphylococcus aureus: identification of two ancestral genetic backgrounds and the associated mec elements. Microb Drug Resist. 2001;7:349-61 pubmed publisher
    ..The data allow tentative identification of an evolutionary pathway for the emergence of pandemic MRSA clones and also provide evidence for the multiple, yet restricted, numbers of acquisition of the mec element by S. aureus...
  58. Valderas M, Gatson J, Wreyford N, Hart M. The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci. J Bacteriol. 2002;184:2465-72 pubmed
    ..epidermidis SodA protein exist as dimers. These data indicate that sodM is found only in S. aureus and not in the CoNS, suggesting an important divergence in the evolution of this genus and a unique role for SodM in S. aureus...
  59. Ohara Nemoto Y, Ikeda Y, Kobayashi M, Sasaki M, Tajika S, Kimura S. Characterization and molecular cloning of a glutamyl endopeptidase from Staphylococcus epidermidis. Microb Pathog. 2002;33:33-41 pubmed
    ..epidermidis infection leading to multiple tissue damages. ..
  60. Yun H, Lee S, Yoon G, Kim S, Choi S, Lee Y, et al. Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital. J Antimicrob Chemother. 2003;51:619-23 pubmed
    ..In conclusion, this work describes the recent, but rapid, emergence of two different types of mupirocin-resistant staphylococci in Korea, and the sequence and mutant characterization of the isoleucyl-tRNA synthetase of CoNS...
  61. Ponnuraj K, Bowden M, Davis S, Gurusiddappa S, Moore D, Choe D, et al. A "dock, lock, and latch" structural model for a staphylococcal adhesin binding to fibrinogen. Cell. 2003;115:217-28 pubmed
    ..We propose that this mechanism represents a general mode of ligand binding for structurally related cell wall-anchored proteins of gram-positive bacteria...
  62. Goji N, Potter A, Perez Casal J. Characterization of two proteins of Staphylococcus aureus isolated from bovine clinical mastitis with homology to glyceraldehyde-3-phosphate dehydrogenase. Vet Microbiol. 2004;99:269-79 pubmed publisher
    ..Both gapB and gapC genes were conserved in 11 strains tested, and the GapC protein was present on the surface of all S. aureus strains...
  63. Hisata K, Kuwahara Arai K, Yamanoto M, Ito T, Nakatomi Y, Cui L, et al. Dissemination of methicillin-resistant staphylococci among healthy Japanese children. J Clin Microbiol. 2005;43:3364-72 pubmed publisher
    ..The fact that MRC-NS strains were prevalent in the community suggested that they might serve as a reservoir for the SCCmec element carried by MRSA strains disseminated in the community...
  64. Mehlin C, Headley C, Klebanoff S. An inflammatory polypeptide complex from Staphylococcus epidermidis: isolation and characterization. J Exp Med. 1999;189:907-18 pubmed
    ..They appeared to exist as a complex or aggregate with activity greater than the component parts. The properties of the S. epidermidis PSMs suggest that they may contribute to the systemic manifestations of Gram-positive sepsis...
  65. Henze U, Berger Bachi B. Penicillin-binding protein 4 overproduction increases beta-lactam resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 1996;40:2121-5 pubmed
    ..The role of the AbcA transporter in methicillin resistance remained unknown...
  66. Balson D, Shaw W. Nucleotide sequence of the rep gene of staphylococcal plasmid pCW7. Plasmid. 1990;24:74-80 pubmed
  67. Breidt F, Hengstenberg W, Finkeldei U, Stewart G. Identification of the genes for the lactose-specific components of the phosphotransferase system in the lac operon of Staphylococcus aureus. J Biol Chem. 1987;262:16444-9 pubmed
    ..aureus and an assay of biological function of the protein expressed in Escherichia coli. The order of the known genes of the S. aureus lac operon is lacF-lacE-lacG, the latter encoding phospho-beta-galactosidase...
  68. Huynh P, Jankovic I, Schnell N, Bruckner R. Characterization of an HPr kinase mutant of Staphylococcus xylosus. J Bacteriol. 2000;182:1895-902 pubmed
    ..These results clearly demonstrate the prominent role of HPr kinase in global control to adjust catabolic capacities of S. xylosus according to the availability of preferred carbon sources. ..
  69. Eisermann R, Fischer R, Kessler U, Neubauer A, Hengstenberg W. Staphylococcal phosphoenolpyruvate-dependent phosphotransferase system. Purification and protein sequencing of the Staphylococcus carnosus histidine-containing protein, and cloning and DNA sequencing of the ptsH gene. Eur J Biochem. 1991;197:9-14 pubmed
    ..carnosus. Comparison of the amino acid sequence of S. carnosus HPr with the HPr sequence of Staphylococcus aureus (derived from peptide sequencing) showed a high degree of similarity. ..
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    ..The mevalonate pathway thus represents a potential antibacterial target in the low-G+C gram-positive cocci...
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    ..Furthermore, no significant influence of sigma(B) on heterologous biofilm formation or on the activity of the global regulator agr was detected...
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    ..Our results suggest that the target of RNAIII activating protein and AAP may contribute to S. epidermidis virulence and biofilm formation...
  73. Lange C, Werckenthin C, Schwarz S. Molecular analysis of the plasmid-borne aacA/aphD resistance gene region of coagulase-negative staphylococci from chickens. J Antimicrob Chemother. 2003;51:1397-401 pubmed publisher
    ..In one of the three plasmids studied, the arrangement of the elements in the aacA/aphD resistance gene area closely resembled that on plasmids pSH6, pSK41 and pUW3626 from Staphylococcus aureus of human origin...
  74. Mongkolrattanothai K, Boyle S, Murphy T, Daum R. Novel non-mecA-containing staphylococcal chromosomal cassette composite island containing pbp4 and tagF genes in a commensal staphylococcal species: a possible reservoir for antibiotic resistance islands in Staphylococcus aureus. Antimicrob Agents Chemother. 2004;48:1823-36 pubmed
    ..In view of the fact that SCC-CI was found in a commensal species, it may represent a reservoir for sequences involved in genetic shuffling between staphylococci and may contribute to the diversity found in SCC elements...
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    ..Results indicated a separate evolution for plasmid- and chromosomally-encoded blaZ. Although a common gene pool seems to exist among staphylococci, exchange of blaZ between strains and species is judged to be an extremely rare event...
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    ..g., the gap-based T-RFLP method, still show superior accuracy in identifying Staphylococcus species other than Staphylococcus aureus...