Staphylococcus aureus subsp. aureus str. Newman

Summary

Alias: Staphylococcus aureus subsp. aureus Newman, Staphylococcus aureus subsp. aureus strain Newman

Top Publications

  1. pmc sigmaB and the sigmaB-dependent arlRS and yabJ-spoVG loci affect capsule formation in Staphylococcus aureus
    Stefan Meier
    Institute of Medical Microbiology, University of Zurich, Gloriastr 32, 8006 Zurich, Switzerland
    Infect Immun 75:4562-71. 2007
  2. pmc CcpA mediates the catabolite repression of tst in Staphylococcus aureus
    Kati Seidl
    Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland
    Infect Immun 76:5093-9. 2008
  3. ncbi sae is essential for expression of the staphylococcal adhesins Eap and Emp
    Niamh Harraghy
    Institute of Medical Microbiology and Hygiene, University of Saarland, D 66421 Homburg Saar, Germany
    Microbiology 151:1789-800. 2005
  4. pmc CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis
    Chunling Li
    Indiana University School of Medicine Northwest, Gary, Indiana 46408, USA
    J Bacteriol 192:3883-92. 2010
  5. pmc Role of Staphylococcus aureus global regulators sae and sigmaB in virulence gene expression during device-related infection
    Christiane Goerke
    Institut für Med Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    Infect Immun 73:3415-21. 2005
  6. pmc A point mutation in the sensor histidine kinase SaeS of Staphylococcus aureus strain Newman alters the response to biocide exposure
    Daniel Schafer
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Bacteriol 191:7306-14. 2009
  7. ncbi Passage of heme-iron across the envelope of Staphylococcus aureus
    Sarkis K Mazmanian
    Committee on Microbiology, Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Science 299:906-9. 2003
  8. pmc Analogs of Eap protein are conserved and prevalent in clinical Staphylococcus aureus isolates
    M Hussain
    Institute of Medical Microbiology, University of Muenster, Muenster, Germany
    Clin Diagn Lab Immunol 8:1271-6. 2001
  9. pmc Inactivation of a two-component signal transduction system, SaeRS, eliminates adherence and attenuates virulence of Staphylococcus aureus
    Xudong Liang
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, Minnesota 55108, USA
    Infect Immun 74:4655-65. 2006
  10. pmc Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus
    M Bischoff
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    J Bacteriol 183:5171-9. 2001

Scientific Experts

  • T E Benson
  • J A Cox
  • Bettina Schulthess
  • Motoyuki Sugai
  • Kati Seidl
  • Seungil Han
  • Niamh Harraghy
  • R Wynn
  • C Wolz
  • Niklas Palmqvist
  • M Bischoff
  • Pieter Jan Haas
  • Kimberly K Jefferson
  • Evelyn J Walsh
  • Jason C Grigg
  • Olaf Schneewind
  • Joanne Purves
  • Bent Postma
  • Timothy J Foster
  • Eric P Skaar
  • Christiane Goerke
  • Thomas Spirig
  • Jos A G Van Strijp
  • Kok P M Van Kessel
  • Hua Xiang
  • Andrew M Edwards
  • M Hussain
  • Lara N Mrak
  • Thomas E Kehl-Fie
  • Chia Y Lee
  • Miranda Johnson
  • Alan Cockayne
  • Julie A Morrissey
  • Madhulatha Pantrangi
  • Palas K Chanda
  • A T Giraudo
  • Chunling Li
  • Rajkrishna Mondal
  • Subrata Sau
  • Keya Sau
  • T J Foster
  • Daniel Schafer
  • Louise M O'Brien
  • Palas Kumar Chanda
  • Anthony R Richardson
  • Michael E P Murphy
  • Andrew L Lovering
  • Christie L Vermeiren
  • Victor J Torres
  • Stefan Meier
  • Tao Xie
  • Ruth C Massey
  • David E Heinrichs
  • Willem J B Van Wamel
  • Xudong Liang
  • Maria Pilar Trotonda
  • Alexandra Pelz
  • Ruiying Wu
  • Carla J C de Haas
  • Duc M Nguyen
  • David J Hosfield
  • Yinong Zong
  • Piotr Gornicki
  • Sthanam V L Narayana
  • Sarkis K Mazmanian
  • Magnus Hook
  • M Hook
  • D Ni Eidhin
  • Champion C S Deivanayagam
  • Louise O'Brien
  • G Reza Malmirchegini
  • David A Gell
  • Robert T Clubb
  • Jiang Zhang
  • Kaavya Krishna Kumar
  • Mengyao Liu
  • Megan Sjodt
  • Benfang Lei
  • Claire F Dickson
  • Joseph A Loo
  • Scott A Robson
  • Yue Feng
  • C von Eiff
  • F M McAleese
  • Xuming Deng
  • K Becker
  • Jiawei Wang
  • Bao Liu
  • MARIA GABRIELA BOWDEN
  • Agnieszka K Zielinska

Detail Information

Publications64

  1. pmc sigmaB and the sigmaB-dependent arlRS and yabJ-spoVG loci affect capsule formation in Staphylococcus aureus
    Stefan Meier
    Institute of Medical Microbiology, University of Zurich, Gloriastr 32, 8006 Zurich, Switzerland
    Infect Immun 75:4562-71. 2007
    ..We hypothesize that ArlR and products of the yabJ-spoVG locus may serve as effectors that modulate sigma(B) control over sigma(B)-dependent genes lacking an apparent sigma(B) promoter...
  2. pmc CcpA mediates the catabolite repression of tst in Staphylococcus aureus
    Kati Seidl
    Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland
    Infect Immun 76:5093-9. 2008
    ..Stabilizing the pH ruled out a pH effect due to acid production during glucose catabolism. CcpA thus directly regulates tst transcription, linking carbohydrate utilization to virulence gene expression in S. aureus...
  3. ncbi sae is essential for expression of the staphylococcal adhesins Eap and Emp
    Niamh Harraghy
    Institute of Medical Microbiology and Hygiene, University of Saarland, D 66421 Homburg Saar, Germany
    Microbiology 151:1789-800. 2005
    ..sae expression was also reduced in the presence of glucose, suggesting that repression of eap and emp in glucose-containing medium may, in part, be a consequence of a decrease in expression of sae...
  4. pmc CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis
    Chunling Li
    Indiana University School of Medicine Northwest, Gary, Indiana 46408, USA
    J Bacteriol 192:3883-92. 2010
    ..aureus infections...
  5. pmc Role of Staphylococcus aureus global regulators sae and sigmaB in virulence gene expression during device-related infection
    Christiane Goerke
    Institut für Med Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    Infect Immun 73:3415-21. 2005
    ..sae had a dominant effect on target gene expression during device-related infection. SigmaB seemed to be less active throughout the infection than under induced conditions in vitro...
  6. pmc A point mutation in the sensor histidine kinase SaeS of Staphylococcus aureus strain Newman alters the response to biocide exposure
    Daniel Schafer
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Bacteriol 191:7306-14. 2009
    ..This may be important for understanding the regulation of virulence in S. aureus...
  7. ncbi Passage of heme-iron across the envelope of Staphylococcus aureus
    Sarkis K Mazmanian
    Committee on Microbiology, Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Science 299:906-9. 2003
    ..Thus, Isd appears to act as an import apparatus that uses cell wall-anchored proteins to relay heme-iron across the bacterial envelope...
  8. pmc Analogs of Eap protein are conserved and prevalent in clinical Staphylococcus aureus isolates
    M Hussain
    Institute of Medical Microbiology, University of Muenster, Muenster, Germany
    Clin Diagn Lab Immunol 8:1271-6. 2001
    ..Thus, Map and Eap may provide a potential novel tool for S. aureus identification and typing...
  9. pmc Inactivation of a two-component signal transduction system, SaeRS, eliminates adherence and attenuates virulence of Staphylococcus aureus
    Xudong Liang
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, Minnesota 55108, USA
    Infect Immun 74:4655-65. 2006
    ..Our results indicate that activation of the SaeRS system may be required for S. aureus to adhere to and invade epithelial cells...
  10. pmc Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus
    M Bischoff
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    J Bacteriol 183:5171-9. 2001
    ..The data presented here suggest that sigma(B) increases sar expression while simultaneously reducing the RNAIII level in a growth phase-dependent manner...
  11. pmc Identification and characterization of a novel 38.5-kilodalton cell surface protein of Staphylococcus aureus with extended-spectrum binding activity for extracellular matrix and plasma proteins
    M Hussain
    Institute of Medical Microbiology, University Hospital of Muenster, Domagkstrasse 10, 48129 Muenster, Germany
    J Bacteriol 183:6778-86. 2001
    ..In conclusion, the biologic characterization of Emp suggests that it is a member of the group of secreted S. aureus molecules that interact with an extended spectrum of host ligands and thereby contribute to S. aureus pathogenicity...
  12. ncbi Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10
    Evelyn J Walsh
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 279:50691-9. 2004
    ..We provide an explanation for the molecular basis for S. aureus adherence to the squamous epithelium and suggest that nasal colonization might be prevented by reagents that inhibit this interaction...
  13. pmc Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenases
    Ruiying Wu
    Structural Biology Center and Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, Illinois 60439, USA
    J Biol Chem 280:2840-6. 2005
    ..Our results imply the evolutionary adaptation of microbial enzymes to unique environments...
  14. pmc A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A
    Champion C S Deivanayagam
    Center for Biophysical Sciences and Engineering, School of Optometry, 244 CBSE, 1025 18th Street South, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    EMBO J 21:6660-72. 2002
    ....
  15. ncbi Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization
    Louise M O'Brien
    Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland
    Cell Microbiol 4:759-70. 2002
    ..We also showed that ClfB is transcribed by S. aureus in the human nares. We propose that ClfB is a major determinant in S. aureus nasal colonization...
  16. ncbi Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A
    Louise O'Brien
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 44:1033-44. 2002
    ..aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis...
  17. ncbi The sae locus of Staphylococcus aureus encodes a two-component regulatory system
    A T Giraudo
    Departamento de Microbiologia e Inmunologia, Facultad de Ciencias Exactas, Físico, Química y Naturales, Universidad Nacional de Rio Cuarto, Cordoba, Argentina
    FEMS Microbiol Lett 177:15-22. 1999
    ....
  18. ncbi Three new members of the serine-aspartate repeat protein multigene family of Staphylococcus aureus
    E Josefsson
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin, Ireland
    Microbiology 144:3387-95. 1998
    ..The sdr locus was present in all 31 S. aureus strains from human and bovine sources tested by Southern hybridization, although in a few strains it contained two rather than three genes...
  19. ncbi Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureus
    D Ni Eidhin
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 30:245-57. 1998
    ....
  20. ncbi The fibrinogen-binding MSCRAMM (clumping factor) of Staphylococcus aureus has a Ca2+-dependent inhibitory site
    D P O'Connell
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Republic of Ireland
    J Biol Chem 273:6821-9. 1998
    ..Mutagenesis studies indicate that the Ca2+-dependent inhibitory site is located within the EF-hand motif at residues 310-321...
  21. ncbi The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level
    A T Giraudo
    Departamento de Microbiologia, Facultad de Ciencias Exactas, Fisico Quimicas y Naturales, Universidad Nacional Río Cuarto, Ruta 36 Km 601, 5800 Rio Cuarto, Cordoba, Argentina
    Arch Microbiol 168:53-8. 1997
    ....
  22. pmc Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the alphaC-domain of human fibrinogen
    Evelyn J Walsh
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 154:550-8. 2008
    ....
  23. ncbi Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus
    D McDevitt
    Microbiology Department, Moyne Institute, Trinity College, Dublin, Ireland
    Mol Microbiol 11:237-48. 1994
    ..Significant homology was found between the ClfA protein and the fibronectin-binding proteins of S. aureus, particularly in the N- and C-termini...
  24. ncbi Characterization of a Tn551-mutant of Staphylococcus aureus defective in the production of several exoproteins
    A T Giraudo
    Departamento de Microbiologia, Facultad de Ciencias Exactas, Fisico Quimicas y Naturales, Universidad Nacional Río Cuarto, Cordoba, Argentina
    Can J Microbiol 40:677-81. 1994
    ..The phenotype of the mutant was different from that of other insertional mutants affecting exoprotein synthesis, such as agr, xpr, or sar. This new mutation has been designated sae (for S. aureus exoprotein expression)...
  25. doi A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity
    Anthony R Richardson
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Science 319:1672-6. 2008
    ..NO.-inducible lactate dehydrogenase activity and NO. resistance distinguish S. aureus from the closely related commensal species S. epidermidis and S. saprophyticus...
  26. ncbi Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease
    F M McAleese
    Microbiology Department, Moyne Institute for Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 276:29969-78. 2001
    ..Cleavage was detected at two sites, one located between residues Ser(197) and Leu(198) and the other between Ala(199) and Val(200). The truncated form of ClfB did not bind fibrinogen...
  27. pmc A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cell Host Microbe 1:109-19. 2007
    ....
  28. ncbi Heme coordination by Staphylococcus aureus IsdE
    Jason C Grigg
    Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada
    J Biol Chem 282:28815-22. 2007
    ..aureus IsdE with respect to heme binding and transport...
  29. ncbi Residues 10-18 within the C5a receptor N terminus compose a binding domain for chemotaxis inhibitory protein of Staphylococcus aureus
    Bent Postma
    Eijkman Winkler Institute, G04 614, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 280:2020-7. 2005
    ..CHIPS may provide new strategies to block the C5aR, which may lead to the development of new C5aR antagonists...
  30. ncbi Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis
    Andrew L Lovering
    Department of Biochemistry and Molecular Biology, and Center for Blood Research, University of British Columbia, 2350 Health Sciences Mall, Vancouver, Canada
    Science 315:1402-5. 2007
    ..The peptidoglycan GTs adopt a fold distinct from those of other GT classes. The structures give insight into critical features of the catalytic mechanism and key interactions required for enzyme inhibition...
  31. doi Antibiotics, arsenate and H2O2 induce the promoter of Staphylococcus aureus cspC gene more strongly than cold
    Palas Kumar Chanda
    Department of Biochemistry, Bose Institute, P1 12 CIT Scheme VII M, Kolkata, W B, India
    J Basic Microbiol 49:205-11. 2009
    ..Their roles in S. aureus cold shock gene expression have been discussed elaborately...
  32. pmc Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance
    Bettina Schulthess
    Institute of Medical Microbiology, University of Zurich, Gloriastr 32, 8006 Zurich, Switzerland
    Antimicrob Agents Chemother 53:1832-9. 2009
    ..We therefore postulate that SpoVG is the major factor of the yabJ-spoVG operon required in S. aureus for capsule formation and antibiotic resistance...
  33. pmc Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus
    Kati Seidl
    Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
    BMC Microbiol 9:95. 2009
    ..This study is the first CcpA-dependent transcriptome and proteome analysis in Staphylococcus aureus, focussing on short-time effects of glucose under stable pH conditions...
  34. pmc Staphylococcal superantigen-like genes, ssl5 and ssl8, are positively regulated by Sae and negatively by Agr in the Newman strain
    Madhulatha Pantrangi
    Molecular Microbiology Laboratory, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
    FEMS Microbiol Lett 308:175-84. 2010
    ..The SigB mutation did not affect ssl5 and ssl8 expression, but they were downregulated in the agr/sigB double mutant, indicating that SigB probably acts synergistically with Agr in their upregulation...
  35. pmc Fur is required for the activation of virulence gene expression through the induction of the sae regulatory system in Staphylococcus aureus
    Miranda Johnson
    Dept of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Int J Med Microbiol 301:44-52. 2011
    ..Hence, we show that Fur is central to a complex regulatory network that is required for the induced expression of a number of important S. aureus virulence determinants in low iron...
  36. doi Characterization of an unusual cold shock protein from Staphylococcus aureus
    Palas K Chanda
    Department of Biochemistry, Bose Institute, Kolkata, India
    J Basic Microbiol 50:519-26. 2010
    ..Analysis of quenching data indicates that each CspC molecule binds with ∼5 contiguous thymine bases of the above ssDNA and binding is cooperative in nature...
  37. pmc Comparison of the regulation, metabolic functions, and roles in virulence of the glyceraldehyde-3-phosphate dehydrogenase homologues gapA and gapB in Staphylococcus aureus
    Joanne Purves
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
    Infect Immun 78:5223-32. 2010
    ..aureus in a Galleria mellonella model of infection, showing for the first time in any bacteria that both glycolysis and gluconeogenesis have important roles in virulence...
  38. pmc Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus
    Thomas E Kehl-Fie
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Host Microbe 10:158-64. 2011
    ..These results suggest that calprotectin contributes to host defense by rendering bacterial pathogens more sensitive to host immune effectors and reducing bacterial growth...
  39. pmc saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus
    Lara N Mrak
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 7:e38453. 2012
    ..Although it remains unclear whether these effects are mediated directly or indirectly, studies done with an sspA::lux reporter suggest they are mediated at a transcriptional level...
  40. pmc Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB
    Hua Xiang
    Key Laboratory for Protein Sciences of Ministry of Education, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
    PLoS Pathog 8:e1002751. 2012
    ..Our results provide a template for the identification of other molecules targeted by S. aureus during its colonization and infection. We propose that other MSCRAMMs like ClfA and SdrG also possess multi-ligand binding properties...
  41. pmc Staphylococcus aureus extracellular adherence protein triggers TNFα release, promoting attachment to endothelial cells via protein A
    Andrew M Edwards
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 7:e43046. 2012
    ..Using a murine bacteraemia model we found that Eap expressing strains cause a more severe infection, demonstrating its role in invasive disease...
  42. pmc Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme
    Thomas Spirig
    Department of Chemistry and Biochemistry and the UCLA Department of Energy Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 288:1065-78. 2013
    ..Other clinically significant Gram-positive pathogens capture Hb using receptors that contain multiple NEAT domains, suggesting that they use a conserved mechanism...
  43. pmc The teicoplanin-associated locus regulator (TcaR) and the intercellular adhesin locus regulator (IcaR) are transcriptional inhibitors of the ica locus in Staphylococcus aureus
    Kimberly K Jefferson
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 186:2449-56. 2004
    ..In summary, TcaR appeared to be a weak negative regulator of transcription of the ica locus, whereas IcaR was a strong negative regulator, and in their absence PNAG production and biofilm formation were enhanced...
  44. ncbi Evidence for three different fibrinogen-binding proteins with unique properties from Staphylococcus aureus strain Newman
    M K Bodén
    Center for Biotechnology, Karolinska Institute, Novum, Huddinge, Sweden
    Microb Pathog 12:289-98. 1992
    ..The 19 kDa fibrinogen-binding protein, which spontaneously aggregates into dimers and larger molecular weight complexes, had a unique NH2-terminal sequence...
  45. ncbi The crystal structure of the antibody N10-staphylococcal nuclease complex at 2.9 A resolution
    P Bossart-Whitaker
    Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543 4000, USA
    J Mol Biol 253:559-75. 1995
    ..Finally, although some of the movement observed in the antibody-bound SNase may be due to crystal contacts, it is clear that some side-chain rearrangements are the result of antigen-antibody interaction...
  46. ncbi One-step evolution of a dimer from a monomeric protein
    S M Green
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Struct Biol 2:746-51. 1995
    ..The spontaneous exchange or swapping of secondary structural elements provides a simple pathway for the formation of large, stable protein/protein interfaces and may play an important role in the evolution of oligomeric proteins...
  47. ncbi NMR structure of a stable "OB-fold" sub-domain isolated from staphylococcal nuclease
    A T Alexandrescu
    Department of Biological Chemistry, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Mol Biol 250:134-43. 1995
    ....
  48. ncbi Crystal structures of the binary Ca2+ and pdTp complexes and the ternary complex of the Asp21-->Glu mutant of staphylococcal nuclease. Implications for catalysis and ligand binding
    A M Libson
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205
    Biochemistry 33:8007-16. 1994
    ..Furthermore, we describe direct structural evidence which explains the cooperativity of Ca2+ and pdTp binding in the ternary complex relative to that of the binary complexes...
  49. pmc Mobile unnatural amino acid side chains in the core of staphylococcal nuclease
    R Wynn
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA
    Protein Sci 5:1026-31. 1996
    ..Additionally, the tight packing observed normally in protein interiors may reflect, in part, the limited numbers of rotamers available to the natural amino acids...
  50. pmc Antibacterial action of extracellular mammalian group IIA phospholipase A2 against grossly clumped Staphylococcus aureus
    M E Dominiecki
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Infect Immun 67:2299-305. 1999
    ..Thus, the extracellular mobilization of group IIA PLA2 during inflammation may provide a mechanism by which the host can control the proliferation and survival of S. aureus even after bacterial clumping...
  51. ncbi Increasing the thermostability of staphylococcal nuclease: implications for the origin of protein thermostability
    J Chen
    Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701 1201, USA
    J Mol Biol 303:125-30. 2000
    ..The mutants here show that increased numbers of electrostatic and hydrogen bonding interactions are not obligatory for large increases in protein stability...
  52. ncbi Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
    David J Hosfield
    Syrrx Inc, San Diego, California 92121, USA
    J Biol Chem 279:8526-9. 2004
    ..Together, these FPPS complexes provide a structural template for the design of novel inhibitors that may prove useful for the treatment of osteoporosis and other clinical indications including cancer...
  53. ncbi Expression of staphylococcal clumping factor A impedes macrophage phagocytosis
    Niklas Palmqvist
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10 A, S 413 46 Goteborg, Sweden
    Microbes Infect 6:188-95. 2004
    ..Both the protection against phagocytosis and the enhanced immunostimulatory activity provided by ClfA expression are likely to contribute to the in vivo virulence of S. aureus...
  54. ncbi Haem recognition by a Staphylococcus aureus NEAT domain
    Jason C Grigg
    Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Mol Microbiol 63:139-49. 2007
    ..An analysis of IsdA structure-sequence alignments indicate that conservation of Tyr(166) is a predictor of haem binding by NEAT domains...
  55. ncbi Crystal structures of Staphylococcus aureus sortase A and its substrate complex
    Yinong Zong
    Center for Biophysical Sciences and Engineering, School of Optometry, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 279:31383-9. 2004
    ..Comparison of the active sites of S. aureus sortase A and sortase B provides insight into substrate specificity and suggests a universal sortase-catalyzed mechanism of bacterial surface protein anchoring in Gram-positive bacteria...
  56. ncbi Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor
    Bent Postma
    Eijkman Winkler Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 172:6994-7001. 2004
    ..This selectivity and high-affinity binding with potent antagonistic effects makes CHIPS a promising lead for the development of new anti-inflammatory compounds for diseases in which damage by neutrophils plays a key role...
  57. ncbi X-ray and thermodynamic studies of staphylococcal nuclease variants I92E and I92K: insights into polarity of the protein interior
    Duc M Nguyen
    Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    J Mol Biol 341:565-74. 2004
    ..Such transient excursions could increase the average polarity, and thus epsilon(app), of the protein interior...
  58. ncbi The primary structure of mitochondrial aspartate aminotransferase from pig heart: peptides obtained by cleavage with pepsin and with Staphylococcus aureus protease
    D Barra
    Ital J Biochem 28:478-90. 1979
    ..In particular, the S. aureus peptides obtained were important for establishing the amidation state of glutamic acid/glutamine residues...
  59. ncbi Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus
    Alexandra Pelz
    Department of Microbial Genetics, University of Tuebingen, Germany
    J Biol Chem 280:32493-8. 2005
    ..Staphyloxanthin was identified as beta-D-glucopyranosyl 1-O-(4,4'-diaponeurosporen-4-oate)-6-O-(12-methyltetradecanoate)...
  60. pmc SarA positively controls bap-dependent biofilm formation in Staphylococcus aureus
    Maria Pilar Trotonda
    Instituto Valenciano de Investigaciones Agrarias, Carretera Náquera Moncada Km 4, 5, 46113 Moncada, Valencia, Spain
    J Bacteriol 187:5790-8. 2005
    ..Based on the previous studies of others as well as our work demonstrating the role for SarA in icaADBC and bap expression, we propose that SarA is an essential regulator controlling biofilm formation in S. aureus...
  61. ncbi The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules
    Pieter Jan Haas
    Eijkman Winkler Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Mol Biol 353:859-72. 2005
    ..Its structural homology to S.aureus SSLs, superantigens, and EAP might help the design of future experiments towards an understanding of the relationship between structure and function of these proteins...
  62. pmc The innate immune modulators staphylococcal complement inhibitor and chemotaxis inhibitory protein of Staphylococcus aureus are located on beta-hemolysin-converting bacteriophages
    Willem J B Van Wamel
    Eijkman Winkler Institute, Room G04 614, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Bacteriol 188:1310-5. 2006
    ..In conclusion, the four human-specific innate immune modulators SCIN, CHIPS, SAK, and SEA form an IEC that is easily transferred among S. aureus strains by a diverse group of beta-hemolysin-converting bacteriophages...
  63. ncbi Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Staphyloccocus aureus: structural basis for NaAD interaction in functional dimer
    Seungil Han
    Pfizer Inc Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    J Mol Biol 360:814-25. 2006
    ..Taken together, these structural results provide a molecular basis for understanding the coupled activity and recognition specificity for S. aureus NaMNAT and for rational design of selective inhibitors...
  64. pmc Folding stability and cooperativity of the three forms of 1-110 residues fragment of staphylococcal nuclease
    Tao Xie
    National Laboratory of Biomacromolecules, Center for Structural and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Biophys J 92:2090-107. 2007
    ..The formation of beta-barrel and overall structure is concerted, but the level of cooperativity is different for the three 1-110 residues SNase fragments...