Staphylococcus aureus subsp. aureus MRSA252

Summary

Alias: Staphylococcus aureus subsp. aureus str. MRSA252, Staphylococcus aureus subsp. aureus strain MRSA252

Top Publications

  1. pmc The teicoplanin-associated locus regulator (TcaR) and the intercellular adhesin locus regulator (IcaR) are transcriptional inhibitors of the ica locus in Staphylococcus aureus
    Kimberly K Jefferson
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 186:2449-56. 2004
  2. pmc A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus
    B Fournier
    Infectious Disease Division and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston 02114 2696, USA
    J Bacteriol 182:3955-64. 2000
  3. pmc A bone sialoprotein-binding protein from Staphylococcus aureus: a member of the staphylococcal Sdr family
    H S Tung
    Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 575, SE 751 23 Uppsala, Sweden
    Biochem J 345:611-9. 2000
  4. ncbi The sae locus of Staphylococcus aureus encodes a two-component regulatory system
    A T Giraudo
    Departamento de Microbiologia e Inmunologia, Facultad de Ciencias Exactas, Físico, Química y Naturales, Universidad Nacional de Rio Cuarto, Cordoba, Argentina
    FEMS Microbiol Lett 177:15-22. 1999
  5. pmc Gene for staphylococcal protein A
    S Lofdahl
    Proc Natl Acad Sci U S A 80:697-701. 1983
  6. ncbi Molecular characterization and expression of a gene encoding a Staphylococcus aureus collagen adhesin
    J M Patti
    Department of Biochemistry, University of Alabama, Birmingham 35294 0005
    J Biol Chem 267:4766-72. 1992
  7. pmc Factors influencing time to vancomycin-induced clearance of nonendocarditis methicillin-resistant Staphylococcus aureus bacteremia: role of platelet microbicidal protein killing and agr genotypes
    Pamela A Moise
    Cubist Pharmaceuticals, Lexington, Massachusetts, USA
    J Infect Dis 201:233-40. 2010
  8. ncbi Conserved interactions in the Staphylococcus aureus DNA PolC chromosome replication machine
    Irina Bruck
    Howard Hughes Medical Institute and Rockefeller University, New York, New York 10021, USA
    J Biol Chem 280:18152-62. 2005
  9. pmc A general method for cloning recA genes of gram-positive bacteria by polymerase chain reaction
    P Duwat
    Laboratoire de Genetique Microbienne, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Bacteriol 174:5171-5. 1992
  10. pmc Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus
    M T Sebulsky
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Bacteriol 182:4394-400. 2000

Research Grants

  1. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003

Patents

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
  2. Plants with increased yield
  3. Plants with increased yield
  4. Process for the production of a fine chemical
  5. Process for the production of lutein
  6. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
  7. Process for the production of fine chemicals
  8. Process for the control of production of fine chemicals
  9. Proteins associated with abiotic stress response and homologs
  10. Methods and oligonucleotides for detection of mastitis causing bacteria

Scientific Experts

Detail Information

Publications62

  1. pmc The teicoplanin-associated locus regulator (TcaR) and the intercellular adhesin locus regulator (IcaR) are transcriptional inhibitors of the ica locus in Staphylococcus aureus
    Kimberly K Jefferson
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 186:2449-56. 2004
    ..In summary, TcaR appeared to be a weak negative regulator of transcription of the ica locus, whereas IcaR was a strong negative regulator, and in their absence PNAG production and biofilm formation were enhanced...
  2. pmc A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus
    B Fournier
    Infectious Disease Division and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston 02114 2696, USA
    J Bacteriol 182:3955-64. 2000
    ..Since the locus arlR-arlS strikingly modifies extracellular proteolytic activity, this locus might also be involved in the virulence of S. aureus...
  3. pmc A bone sialoprotein-binding protein from Staphylococcus aureus: a member of the staphylococcal Sdr family
    H S Tung
    Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 575, SE 751 23 Uppsala, Sweden
    Biochem J 345:611-9. 2000
    ..The S. aureus Bbp protein may be important in the localization of bacteria to bone tissue, and thus might be of relevance in the pathogenicity of osteomyelitis...
  4. ncbi The sae locus of Staphylococcus aureus encodes a two-component regulatory system
    A T Giraudo
    Departamento de Microbiologia e Inmunologia, Facultad de Ciencias Exactas, Físico, Química y Naturales, Universidad Nacional de Rio Cuarto, Cordoba, Argentina
    FEMS Microbiol Lett 177:15-22. 1999
    ....
  5. pmc Gene for staphylococcal protein A
    S Lofdahl
    Proc Natl Acad Sci U S A 80:697-701. 1983
    ..Upstream from the structural gene there is a possible promoter region and a ribosomal binding sequence typical of gram-positive bacteria. The initiation codon is TTG...
  6. ncbi Molecular characterization and expression of a gene encoding a Staphylococcus aureus collagen adhesin
    J M Patti
    Department of Biochemistry, University of Alabama, Birmingham 35294 0005
    J Biol Chem 267:4766-72. 1992
    ..Finally, the bacterial lysate containing the recombinant adhesin can effectively inhibit the binding of soluble collagen to cells of S. aureus...
  7. pmc Factors influencing time to vancomycin-induced clearance of nonendocarditis methicillin-resistant Staphylococcus aureus bacteremia: role of platelet microbicidal protein killing and agr genotypes
    Pamela A Moise
    Cubist Pharmaceuticals, Lexington, Massachusetts, USA
    J Infect Dis 201:233-40. 2010
    ..This investigation evaluated the interrelationship of these factors with time to clearance of MRSA bacteremia during vancomycin therapy in patients without endocarditis...
  8. ncbi Conserved interactions in the Staphylococcus aureus DNA PolC chromosome replication machine
    Irina Bruck
    Howard Hughes Medical Institute and Rockefeller University, New York, New York 10021, USA
    J Biol Chem 280:18152-62. 2005
    ..Nevertheless, these overall findings underscore the conservation in structure and function of Gram-positive and Gram-negative replicases despite >1 billion years of evolutionary distance between them...
  9. pmc A general method for cloning recA genes of gram-positive bacteria by polymerase chain reaction
    P Duwat
    Laboratoire de Genetique Microbienne, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Bacteriol 174:5171-5. 1992
    ..This method is particularly useful for the recovery of the recA genes of gram-positive bacteria and avoids the difficulties of using a genetic complementation test for cloning...
  10. pmc Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus
    M T Sebulsky
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Bacteriol 182:4394-400. 2000
    ..By using the Fur titration assay, it was shown that the Fur box sequences upstream of fhuCBG are recognized by the Escherichia coli Fur protein...
  11. ncbi Modification of autolysis by synthetic peptides derived from the presumptive binding domain of Staphylococcus aureus autolysin
    M Takano
    Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co, Ltd, Saitama, Japan
    Microbiol Immunol 44:463-72. 2000
    ..aureus autolysin activities. These peptides, especially the 10-mer peptide B9 (PGTKLYTVPW) that represents the C-terminal half of A10 and N-terminal half of A11, may be important segments for Atl to bind to the cell surface...
  12. pmc An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190
    K Kaneda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 98:932-7. 2001
    ..aureus and of the different enzymatic properties of mammalian (type 1) and S. aureus (type 2) isomerases, this unusual enzyme is considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus...
  13. ncbi Identification, cloning, and expression of a functional phenylalanyl-tRNA synthetase (pheRS) from Staphylococcus aureus
    J W Savopoulos
    GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park North, Coldharbour Road, Harlow, Essex CM19 5AD, United Kingdom
    Protein Expr Purif 21:470-84. 2001
    ..aureus (Oxford Strain) and demonstrate that Michaelis-Menten parameters for both recombinant and native enzyme, at least for phenylalanine tRNA aminoacylation are comparable...
  14. pmc Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus
    M Bischoff
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    J Bacteriol 183:5171-9. 2001
    ..The data presented here suggest that sigma(B) increases sar expression while simultaneously reducing the RNAIII level in a growth phase-dependent manner...
  15. ncbi Arsenate reductase from S. aureus plasmid pI258 is a phosphatase drafted for redox duty
    I Zegers
    Dienst Ultrastruktuur, Vlaams Interuniversitair Instituut voor Biotechnologie VIB, Vrije Universiteit Brussel, Paardenstraat 65, B 1640 St Genesius Rode, Belgium
    Nat Struct Biol 8:843-7. 2001
    ..The reaction is associated with major structural changes in the ArsC...
  16. ncbi Expression, purification, and characterization of peptidyl-tRNA hydrolase from Staphylococcus aureus
    Paul D Bonin
    Cell and Molecular Biology, Rockville, Maryland, USA
    Protein Expr Purif 24:123-30. 2002
    ..aureus Pth was determined to be 2.8 microM. A far UV circular dichroism spectrum revealed that His-tagged S. aureus Pth appears to have a structured core predominated by beta-sheet...
  17. pmc Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus
    Que Chi Truong-Bolduc
    Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    J Bacteriol 185:3127-38. 2003
    ..Collectively, these results indicate that NorR is a multifunctional regulator, affecting cell surface properties as well as the expression of NorA and likely other multidrug resistance efflux pumps...
  18. ncbi Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase
    Alfredo Torres-Larios
    Laboratoire de Biologie et Genomique Structurales, IGBMC, 1 rue Laurent Fries, BP 10142, 67400 Illkirch Cedex, France
    J Mol Biol 331:201-11. 2003
    ..The structural analysis suggests that, while the small substrates can bind in any order, they must be in place before productive tRNA binding can occur...
  19. pmc MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation
    Jutta Rossi
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    Antimicrob Agents Chemother 47:2558-64. 2003
    ..These observations suggest that MsrR is a new component involved in sarA attenuation and the regulatory network controlling virulence gene expression in S. aureus...
  20. pmc Transcriptional regulation of the Staphylococcus aureus thioredoxin and thioredoxin reductase genes in response to oxygen and disulfide stress
    Orit Uziel
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Bacteriol 186:326-34. 2004
    ..This observation, coupled with structural differences between the bacterial and mammalian thioredoxin reductases, suggests that it may serve as a target for the development of new antimicrobials...
  21. pmc Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr
    A L Cheung
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 89:6462-6. 1992
    ..aureus strain with a genetic background similar to strain 8325-4. This locus on the S. aureus chromosome, possibly regulatory in nature, has been designated sar for staphylococcal accessory regulator...
  22. ncbi Refined crystal structure of beta-lactamase from Staphylococcus aureus PC1 at 2.0 A resolution
    O Herzberg
    Center for Advanced Research in Biotechnology, Maryland Biotechnology Institute, University of Maryland, Rockville 20850
    J Mol Biol 217:701-19. 1991
    ..This, and an adjacent cavity occupied by three solvent molecules partially separate the omega-loop associated with the active site from the rest of the protein.(ABSTRACT TRUNCATED AT 250 WORDS)..
  23. pmc Genetic background affects stability of mecA in Staphylococcus aureus
    Yuki Katayama
    Department of Bacteriology, Fuculty of Medicine, Juntendo University, Tokyo Japan
    J Clin Microbiol 43:2380-3. 2005
    ..These data support the hypothesis that the presence of mecA within relatively few clonal complexes is partly due to genetic factors that are permissive of mecA and its gene product...
  24. pmc SarA positively controls bap-dependent biofilm formation in Staphylococcus aureus
    Maria Pilar Trotonda
    Instituto Valenciano de Investigaciones Agrarias, Carretera Náquera Moncada Km 4, 5, 46113 Moncada, Valencia, Spain
    J Bacteriol 187:5790-8. 2005
    ..Based on the previous studies of others as well as our work demonstrating the role for SarA in icaADBC and bap expression, we propose that SarA is an essential regulator controlling biofilm formation in S. aureus...
  25. pmc Successful multiresistant community-associated methicillin-resistant Staphylococcus aureus lineage from Taipei, Taiwan, that carries either the novel Staphylococcal chromosome cassette mec (SCCmec) type VT or SCCmec type IV
    Susan Boyle-Vavra
    Department of Pediatrics, Section of Infectious Diseases, University of Chicago, IL, 60637, USA
    J Clin Microbiol 43:4719-30. 2005
    ..SCCmec V(T) is a novel SCCmec variant that is found in multiply resistant CAMRSA strains with sequence type 59 in Taipei in association with the PVL leukotoxin genes...
  26. ncbi A slipped-mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate delta- and alpha-haemolysins
    Katrina Traber
    Molecular Pathogenesis Program and Department of Microbiology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mol Microbiol 59:1519-30. 2006
    ..The occurrence of this mutation in a clinical isolate indicates that it is not simply a laboratory phenomenon, and may represent a naturally occurring mechanism for the modulation of agr activity...
  27. pmc Structure of Staphylococcus aureus cytidine monophosphate kinase in complex with cytidine 5'-monophosphate
    Balvinder Dhaliwal
    Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:710-5. 2006
    ..Inhibitors are required to treat the widespread hospital infection methicillin-resistant S. aureus (MRSA), currently a major public health concern...
  28. pmc Structural basis for the aldolase and epimerase activities of Staphylococcus aureus dihydroneopterin aldolase
    Jaroslaw Blaszczyk
    Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Mol Biol 368:161-9. 2007
    ..Three active site residues (E22, K100, and Y54) function coordinately during catalysis: together, they organize the catalytic center assembly, and individually, each plays a central role at different stages of the catalytic cycle...
  29. ncbi Exploitation of structural and regulatory diversity in glutamate racemases
    Tomas Lundqvist
    AstraZeneca Global Structural Chemistry, AstraZeneca R and D Molndal, SE 431 83, Molndal, Sweden
    Nature 447:817-22. 2007
    ..These structural, kinetic and mutational studies provide insight into the physiological regulation of these essential enzymes and provide a basis for designing narrow-spectrum antimicrobial agents...
  30. doi Coupling of domain swapping to kinetic stability in a thioredoxin mutant
    Abel Garcia-Pino
    Department of Molecular and Cellular Interactions, Vlaams Instituut voor Biotechnologie, Brussels, Belgium
    J Mol Biol 385:1590-9. 2009
    ....
  31. pmc The amino acid sequence of Staphylococcus aureus penicillinase
    R P Ambler
    Biochem J 151:197-218. 1975
    ..K., from whom copies may be obtained on the terms given in Biochem. J. (1975) 145, 5...
  32. doi New design platform for malonyl-CoA-acyl carrier protein transacylase
    Seung Kon Hong
    Korea Institute of Science and Technology, Life Sciences Division, Seoul, Republic of Korea
    FEBS Lett 584:1240-4. 2010
    ..Mutagenesis results suggest that Ser91 and His199 are the catalytic dyad...
  33. pmc Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis
    Gordon Y C Cheung
    Laboratory of Human Bacterial Pathogenesis, NIAID, NIH, Bldg 33, 1W10, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Infect Immun 79:1927-35. 2011
    ..Our findings demonstrate that agr functionality is critical for CA-MRSA disease and indicate that an adaptation of the agr regulon contributed to the evolution of highly pathogenic CA-MRSA...
  34. doi LytR-CpsA-Psr proteins in Staphylococcus aureus display partial functional redundancy and the deletion of all three severely impairs septum placement and cell separation
    Benjamin Over
    Institute of Medical Microbiology, University of Zurich, Switzerland
    FEMS Microbiol Lett 320:142-51. 2011
    ....
  35. pmc Rsp inhibits attachment and biofilm formation by repressing fnbA in Staphylococcus aureus MW2
    Mei G Lei
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Slot 511, Little Rock, AR 72205, USA
    J Bacteriol 193:5231-41. 2011
    ....
  36. ncbi Comparative biochemical and molecular analysis of the Staphylococcus hyicus, Staphylococcus aureus and a hybrid lipase. Indication for a C-terminal phospholipase domain
    K Nikoleit
    Universitat Tubingen, Germany
    Eur J Biochem 228:732-8. 1995
    ..hyicus lipase. The fact that two closely related enzymes differ in the need for Ca2+ underscores the notion that it plays a structural rather than a catalytic role...
  37. ncbi Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus
    L Janzon
    Department of Bacteriology, Karolinska Institutet, Stockholm, Sweden
    Mol Gen Genet 219:480-5. 1989
    ..Determination of hld mRNA half-life in different growth phases indicated that this regulation is at the level of transcription...
  38. ncbi Cloning and sequence determination of six Staphylococcus aureus beta-lactamases and their expression in Escherichia coli and Staphylococcus aureus
    A K East
    Department of Biochemistry, University of Oxford, UK
    J Gen Microbiol 135:1001-15. 1989
    ....
  39. ncbi Nucleotide sequence analysis of the gene for protein A from Staphylococcus aureus Cowan 1 (NCTC8530) and its enhanced expression in Escherichia coli
    H L Shuttleworth
    Microbial Technology Laboratory, PHLS, Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wilts, U K
    Gene 58:283-95. 1987
    ..The homology to the latter probably identifies the Fc-binding region in the immunoglobulin-binding domains of SPA. Enhanced production of SPA in Escherichia coli was achieved using the lac promoter immediately upstream from the spa gene...
  40. ncbi The phosphoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: properties, mechanism, and regulation
    J Reizer
    Department of Biology, University of California at San Diego, La Jolla
    Crit Rev Microbiol 15:297-338. 1988
    ....
  41. pmc Nucleotide sequence and expression of the beta-lactamase gene from Staphylococcus aureus plasmid pI258 in Escherichia coli, Bacillus subtilis, and Staphylococcus aureus
    P Z Wang
    J Bacteriol 169:1763-6. 1987
    ..pWN101 was structurally stable and the beta-lactamase gene was expressed efficiently from its native promoter and ribosome-binding site in all three hosts...
  42. ncbi Bacterial resistance to beta-lactam antibiotics: crystal structure of beta-lactamase from Staphylococcus aureus PC1 at 2.5 A resolution
    O Herzberg
    Science 236:694-701. 1987
    ..The unusual topology of the secondary structure units is relevant to questions concerning the evolutionary relation to the beta-lactam target enzymes of the bacterial cell wall...
  43. ncbi Amino acid sequence of the amphiphilic phosphocarrier protein factor IIILac of the lactose-specific phosphotransferase system of Staphylococcus
    K Stuber
    Biochemistry 24:1164-8. 1985
    ..The N-terminal part of the protein comprising approximately one-third of the chain exhibits in vitro affinity toward membrane-bound enzyme IILac...
  44. pmc Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110
    M Matsumura
    J Bacteriol 160:413-20. 1984
    ..The difference in thermostability between the two enzymes caused by a single amino acid replacement is discussed in light of electrostatic effects...
  45. ncbi A genetic system for analysis of staphylococcal nuclease
    D Shortle
    Gene 22:181-9. 1983
    ..In combination with present methods for efficient in vitro mutagenesis, this plasmid-based genetic system can be applied to the detailed genetic analysis of this small, biochemically and biophysically well-characterized enzyme...
  46. ncbi Plasmid-determined bleomycin resistance in Staphylococcus aureus
    D Semon
    Plasmid 17:46-53. 1987
    ..The bleomycin resistance determinant of the gram-positive plasmid pUB110 was compared to that of the enterobacterial transposon Tn5; limited regions of close relatedness could be identified...
  47. ncbi Unique features in the ribosome binding site sequence of the gram-positive Staphylococcus aureus beta-lactamase gene
    J R McLaughlin
    J Biol Chem 256:11283-91. 1981
    ....
  48. ncbi A homologue to the Escherichia coli alkyl hydroperoxide reductase AhpC is induced by osmotic upshock in Staphylococcus aureus
    L Armstrong-Buisseret
    Department of Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agricultural and Food Sciences, Leicestershire, UK
    Microbiology 141:1655-61. 1995
    ..Exposure of S. aureus to varying concentrations of H202 did not result in the detectable induction of AhpC...
  49. ncbi Identification of the active-site nucleophile in 6-phospho-beta-galactosidase from Staphylococcus aureus by labelling with synthetic inhibitors
    P Staedtler
    Arbeitsgruppe Physiologie der Mikroorganismen, Abteilung Biologie, Ruhr Universitat Bochum, Germany
    Eur J Biochem 232:658-63. 1995
    ..It was shown to be identical to an authentic, synthetic sample. From this, it is evident that E375 is the active-site nucleophile of 6-phospho-galactosidase, consistent with previous findings for enzymes in this family...
  50. pmc Nucleotide sequence of the blaZ gene of the Staphylococcus aureus beta-lactamase transposon Tn4002
    M T Gillespie
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Nucleic Acids Res 17:8854. 1989
  51. ncbi Identification of a chromosomally encoded ABC-transport system with which the staphylococcal erythromycin exporter MsrA may interact
    J I Ross
    Department of Microbiology, University of Leeds, UK
    Gene 153:93-8. 1995
    ..There was no further sequence similarity outside these conserved regions. These results indicate that the chromosomes of S. hominis and S. aureus contain sequences encoding a potential TM protein with which MsrA might interact...
  52. ncbi A genetic and molecular characterization of the recA gene from Staphylococcus aureus
    K W Bayles
    Department of Biological Sciences, University of Maryland, Baltimore 21228
    Gene 147:13-20. 1994
    ..Furthermore, genetic and physical mapping of S. aureus recA placed it in the same region as the uvs-568 mutation. These data strongly suggest that these mutations represent different alleles of the same recA gene...
  53. pmc Sequencing of leucocidin R from Staphylococcus aureus P83 suggests that staphylococcal leucocidins and gamma-hemolysin are members of a single, two-component family of toxins
    G Supersac
    Institut de Bacteriologie de la Faculte de Medecine, Strasbourg, France
    Infect Immun 61:580-7. 1993
    ....
  54. ncbi Characterization of a Staphylococcus aureus transposon, Tn5405, located within Tn5404 and carrying the aminoglycoside resistance genes, aphA-3 and aadE
    A Derbise
    National Reference Center for Staphylococci, Unité des Staphylocoques, Institut Pasteur, Paris, France
    Plasmid 35:174-88. 1996
    ..IS1182 was not detected in the DNA of 4 of the 17 tested MRSA isolates containing aphA-3 and resistant to streptomycin. Thus, aphA-3 and aadE genes are not disseminated only by Tn5405 or related transposons delimited by IS1182...
  55. ncbi Chorismate synthase from Staphylococcus aureus
    M J Horsburgh
    Division of Biochemistry and Molecular Biology, University of Glasgow, UK
    Microbiology 142:2943-50. 1996
    ..The properties of S. aureus chorismate synthase are compared with those of the B. subtilis and E. coli enzymes...
  56. pmc Localized perforation of the cell wall by a major autolysin: atl gene products and the onset of penicillin-induced lysis of Staphylococcus aureus
    M Sugai
    Department of Microbiology, Hiroshima University School of Dentistry, Japan
    J Bacteriol 179:2958-62. 1997
    ....
  57. ncbi Subcellular localization of the major autolysin, ATL and its processed proteins in Staphylococcus aureus
    H Komatsuzawa
    Department of Microbiology, Hiroshima University School of Dentistry, Japan
    Microbiol Immunol 41:469-79. 1997
    ..We suggest that the 138-kDa ATL undergoes processing through intermediate proteins (115- and 85-kDa proteins) to mature as the active cell cluster-dispersing enzymes 51-kDa GL and 62-kDa AM on the cell surface...
  58. ncbi Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus
    M Hennig
    Nat Struct Biol 5:357-62. 1998
    ..The structural information and results of site directed mutagenesis allow an enzyme reaction mechanism to be proposed...
  59. ncbi Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus
    N Noguchi
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
    FEMS Microbiol Lett 172:247-53. 1999
    ..Our results indicated that four or more antiseptic-resistance genes exist in methicillin-resistant S. aureus and that antiseptic-resistant methicillin-resistant S. aureus strains without qacA and smr are widely spread in Japan...
  60. pmc Complete nucleotide sequence of IS431mec in Staphylococcus aureus
    L Barberis-Maino
    Institute of Medical Microbiology, University of Zurich, Switzerland
    Nucleic Acids Res 18:5548. 1990
  61. ncbi Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis
    A Bouhss
    Biochimie Structurale et Cellulaire, CNRS, Batiment 430, Universite Paris Sud, F 91405, Orsay, France
    Mol Microbiol 34:576-85. 1999
    ..It was noteworthy that S. aureus MraY was functional in E. coli. An increased MraY transferase activity was observed only with the untruncated hybrids from both organisms...
  62. ncbi The essential catalytic redox couple in arsenate reductase from Staphylococcus aureus
    J Messens
    Dienst Ultrastructuur, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Belgium
    Biochemistry 38:16857-65. 1999
    ..From the peptide-mass profiles, cysteines 82 and 89 were identified as the redox couple of ArsC necessary to reduce arsenate to arsenite...

Research Grants1

  1. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003
    ..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..

Patents12

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  2. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  3. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  4. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  5. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  6. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  7. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  8. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  9. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  10. Methods and oligonucleotides for detection of mastitis causing bacteria
    Patent Number: EP2231866-A1; Date:2010-09-29
  11. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  12. Process for the production of a fine chemical
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