Lactococcus lactis

Summary

Alias: "Bacterium lactis" Lister 1873, Bacterium lacti, Lactococcus lactis (Lister 1873) Schleifer et al. 1986, Streptococcus lactis, Streptococcus lactis (Lister 1873) Lohnis 1909 (Approved Lists 1980), Lactococcus lactis (Lohnis) Schleifer et al. 1986

Top Publications

  1. Anba J, Bidnenko E, Hillier A, Ehrlich D, Chopin M. Characterization of the lactococcal abiD1 gene coding for phage abortive infection. J Bacteriol. 1995;177:3818-23 pubmed
    ..Expression of abiD1 under the control of a T7 promoter induced a lag phase in Lactococcus lactis cell growth, suggesting that overproduction of AbiD1 could be toxic for the cells...
  2. Li L, Heidemann Olsen R, Ye L, Yan H, Nie Q, Meng H, et al. Antimicrobial Resistance and Resistance Genes in Aerobic Bacteria Isolated from Pork at Slaughter. J Food Prot. 2016;79:589-97 pubmed publisher
    ..and Oceanobacillus sp.; blaCMY-2 in Lactococcus lactis, Klebsiella oxytoca, Serratia marcescens, Acinetobacter baumannii, and Myroides phaeus; tet(L) in M...
  3. Ben Harb S, Saint Eve A, Panouillé M, Souchon I, Bonnarme P, Dugat Bony E, et al. Design of microbial consortia for the fermentation of pea-protein-enriched emulsions. Int J Food Microbiol. 2019;293:124-136 pubmed publisher
    ..Lactic acid bacteria assigned to Lactobacillus plantarum, Lactobacillus rhamnosus, Lactococcus lactis and Lactobacillus casei species grew well in both the pea and pea:milk emulsions...
  4. Shandilya U, Sharma A, Kapila R, Kansal V. Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice. J Sci Food Agric. 2016;96:3180-7 pubmed publisher
    ..Two types of probiotic Dahi were prepared by co-culturing Dahi bacteria (Lactococcus lactis ssp. cremoris NCDC-86 and Lactococcus lactis ssp...
  5. Li C, Ren Y, Jiang S, Zhou S, Zhao J, Wang R, et al. Effects of dietary supplementation of four strains of lactic acid bacteria on growth, immune-related response and genes expression of the juvenile sea cucumber Apostichopus japonicus Selenka. Fish Shellfish Immunol. 2018;74:69-75 pubmed publisher
    ..e. Lactobacillus plantarum LL11 (LP), Weissella confuse LS13 (WC), Lactococcus lactis LH8 (LL) and Enterococcus faecalis LC3 (ES)] isolated from marine fish on growth, immune response and ..
  6. Shen J, Chen J, Jensen P, Solem C. Development of a novel, robust and cost-efficient process for valorizing dairy waste exemplified by ethanol production. Microb Cell Fact. 2019;18:51 pubmed publisher
    ..After complementing with the Leloir pathway (galMKTE) from Lactococcus lactis, co-metabolization of galactose and glucose was accomplished...
  7. Baker J, Lindsay E, Faustoferri R, To T, Hendrickson E, He X, et al. Characterization of the Trehalose Utilization Operon in Streptococcus mutans Reveals that the TreR Transcriptional Regulator Is Involved in Stress Response Pathways and Toxin Production. J Bacteriol. 2018;200: pubmed publisher
    ..mutans to inhibit the growth of the competing species Streptococcus gordonii and Lactococcus lactis Taking the results together, this study solidifies the role of the S...
  8. Strasser B, Geiger D, Schauer M, Gostner J, Gatterer H, Burtscher M, et al. Probiotic Supplements Beneficially Affect Tryptophan-Kynurenine Metabolism and Reduce the Incidence of Upper Respiratory Tract Infections in Trained Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial. Nutrients. 2016;8: pubmed
    ..faecium W54, Lactobacillus acidophilus W22, Lactobacillus brevis W63, and Lactococcus lactis W58) or placebo once per day for 12 weeks...
  9. Guarcello R, de Angelis M, Settanni L, Formiglio S, Gaglio R, Minervini F, et al. Selection of Amine-Oxidizing Dairy Lactic Acid Bacteria and Identification of the Enzyme and Gene Involved in the Decrease of Biogenic Amines. Appl Environ Microbiol. 2016;82:6870-6880 pubmed publisher
    ..rhamnosus), Leuconostoc species (Leuconostoc lactis and Ln. mesenteroides), Pediococcus pentosaceus, Lactococcus lactis, Streptococcus species (Streptococcus gallolyticus and S...

More Information

Publications411 found, 100 shown here

  1. Cruciata M, Gaglio R, Scatassa M, Sala G, Cardamone C, Palmeri M, et al. Formation and Characterization of Early Bacterial Biofilms on Different Wood Typologies Applied in Dairy Production. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..The species most frequently present were Lactobacillus fermentum and Lactococcus lactis LAB found on the surfaces of the wooden vats in this study showed interesting characteristics important ..
  2. Kawahara M, Nemoto M, Nakata T, Kondo S, Takahashi H, Kimura B, et al. Anti-inflammatory properties of fermented soy milk with Lactococcus lactis subsp. lactis S-SU2 in murine macrophage RAW264.7 cells and DSS-induced IBD model mice. Int Immunopharmacol. 2015;26:295-303 pubmed publisher
    Six lactic acid bacteria strains (four Lactobacillus plantarum strains and one each of Lactococcus lactis subsp. lactis and Pediococcus pentosaceus) have been isolated and shown to possess anti-oxidant activity...
  3. Scatassa M, Gaglio R, Macaluso G, Francesca N, Randazzo W, Cardamone C, et al. Transfer, composition and technological characterization of the lactic acid bacterial populations of the wooden vats used to produce traditional stretched cheeses. Food Microbiol. 2015;52:31-41 pubmed publisher
    ..faecium was found in all wooden vats and the species most frequently isolated were Enterococcus faecalis, Lactococcus lactis, Leuconostoc mesenteroides, Pediococcus acidilactici and Streptococcus thermophilus...
  4. Ren J, Na D, Yoo S. Optimization of chemico-physical transformation methods for various bacterial species using diverse chemical compounds and nanomaterials. J Biotechnol. 2018;288:55-60 pubmed publisher
    ..The best transformation efficiencies were achieved as follows; 2.84 × 104 CFU/μg DNA in Lactococcus lactis subsp. lactics (0.1 M CsCl and gold(III) chloride), 3...
  5. Khota W, Pholsen S, Higgs D, Cai Y. Natural lactic acid bacteria population of tropical grasses and their fermentation factor analysis of silage prepared with cellulase and inoculant. J Dairy Sci. 2016;99:9768-9781 pubmed publisher
    ..Lactobacillus acidipiscis, Leuconostoc pseudomesenteroides, Leuconostoc garlicum, Weissella confusa, and Lactococcus lactis. Lactobacillus plantarum and L...
  6. Ali N, Sarwar K, Mazhar S, Liaqat I, Andleeb S, Mazhar B, et al. Effect of medicinal plants, Heavy metals and antibiotics against pathogenic bacteria isolated from raw, Boiled and pasteurized milk. Pak J Pharm Sci. 2017;30:2173-2182 pubmed
    ..Streptococcus sp. and Staphylococcus. Ribotyping revealed S2 as Pseudomonas fluorescens, S5 as Lactococcus lactis and S9 as Lactobacillus acidophilus...
  7. LaRoche Johnston F, Monat C, Cousineau B. Recent horizontal transfer, functional adaptation and dissemination of a bacterial group II intron. BMC Evol Biol. 2016;16:223 pubmed
    ..We characterized the functional and evolutionary relationship between the model group II intron from Lactococcus lactis, Ll.LtrB, and Ef.PcfG, a newly discovered intron from a clinical strain of Enterococcus faecalis. Ef...
  8. Kimoto Nira H, Moriya N, Hayakawa S, Kuramasu K, Ohmori H, Yamasaki S, et al. Effects of rare sugar D-allulose on acid production and probiotic activities of dairy lactic acid bacteria. J Dairy Sci. 2017;100:5936-5944 pubmed publisher
    ..In contrast, among the dairy probiotic candidates, Lactococcus lactis H61, which has beneficial effects for human skin when drunk as part of fermented milk, was the only strain ..
  9. Moreno I, Marasca E, de Sá P, de Souza Moitinho J, Marquezini M, Alves M, et al. Evaluation of Probiotic Potential of Bacteriocinogenic Lactic Acid Bacteria Strains Isolated from Meat Products. Probiotics Antimicrob Proteins. 2018;10:762-774 pubmed publisher
    ..They were presumptively identified as Lactococcus lactis subsp. cremoris CTC 204 and CTC 483, L. lactis subsp...
  10. Asmat T, Agarwal V, Saleh M, Hammerschmidt S. Endocytosis of Streptococcus pneumoniae via the polymeric immunoglobulin receptor of epithelial cells relies on clathrin and caveolin dependent mechanisms. Int J Med Microbiol. 2014;304:1233-46 pubmed publisher
    ..fluorescence microscopy of pIgR-expressing epithelial cells infected with pneumococci or heterologous Lactococcus lactis expressing PspC demonstrated bacterial co-localization with fluorescent-tagged clathrin and early as well as ..
  11. Ballal S, Veiga P, Fenn K, Michaud M, Kim J, Gallini C, et al. Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons. Proc Natl Acad Sci U S A. 2015;112:7803-8 pubmed publisher
    ..By varying the number of strains used in the FMP, we found that Lactococcus lactis I-1631 was sufficient to ameliorate colitis...
  12. Yunita D, Dodd C. Microbial community dynamics of a blue-veined raw milk cheese from the United Kingdom. J Dairy Sci. 2018;101:4923-4935 pubmed publisher
    ..A diverse microbiota containing Lactococcus lactis ssp...
  13. Toy N, Özogul F, Özogul Y. The influence of the cell free solution of lactic acid bacteria on tyramine production by food borne-pathogens in tyrosine decarboxylase broth. Food Chem. 2015;173:45-53 pubmed publisher
    ..Tyramine production by Escherichia coli was also inhibited by 50% CFS of Lactococcus lactis subsp. lactis and 25% CFS of Leuconostoc lactis. subsp. cremoris. The inhibitor effect of 50% CFS of P...
  14. Carpino S, Randazzo C, Pino A, Russo N, Rapisarda T, Belvedere G, et al. Influence of PDO Ragusano cheese biofilm microbiota on flavour compounds formation. Food Microbiol. 2017;61:126-135 pubmed publisher
    ..05) between some lactic acid bacteria (LAB) and VOCs: such as Enterococcus hirae with alcohols, Lactococcus lactis, Lactobacillus plantarum, Lactobacillus casei and Lactobacillus delbrueckii with aldehydes, and ..
  15. Giarma E, Amanetidou E, Toufexi A, Touraki M. Defense systems in developing Artemia franciscana nauplii and their modulation by probiotic bacteria offer protection against a Vibrio anguillarum challenge. Fish Shellfish Immunol. 2017;66:163-172 pubmed publisher
    ..The effect of the administration of the probiotic bacteria Bacillus subtilis, Lactobacillus plantarum and Lactococcus lactis either alone or in combination with the pathogen was evaluated...
  16. Suzuki H, Tsuji R, Sugamata M, Yamamoto N, Yamamoto N, Kanauchi O. Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice. Int J Mol Med. 2019;43:426-434 pubmed publisher
    ..Based on these results, LC‑plasma may be effective against DENV infection by stimulating pDCs, which results in the increased production of anti‑viral factors. ..
  17. Bourdineaud J, Nehme B, Tesse S, Lonvaud Funel A. A bacterial gene homologous to ABC transporters protect Oenococcus oeni from ethanol and other stress factors in wine. Int J Food Microbiol. 2004;92:1-14 pubmed
    ..with the subfamily of ATP-dependent multidrug resistance (MDR) proteins, most notably the bacterial Lactococcus lactis LmrA homologue of the human MDR1 P-glycoprotein...
  18. Kimoto Nira H, Yamasaki S, Sasaki K, Moriya N, Takenaka A, Suzuki C. New lactic acid bacterial strains from traditional Mongolian fermented milk products have altered adhesion to porcine gastric mucin depending on the carbon source. Anim Sci J. 2015;86:325-32 pubmed publisher
    ..bulgaricus strains 6-8 and 8-1 than with Lactobacillus rhamnosus GG (positive control). Lactococcus lactis subsp. cremoris strain 7-1 adhered to mucin as effectively as did strain GG...
  19. Gutiérrez S, Martínez Blanco H, Rodríguez Aparicio L, Ferrero M. Effect of fermented broth from lactic acid bacteria on pathogenic bacteria proliferation. J Dairy Sci. 2016;99:2654-2665 pubmed publisher
    ..The fermented broth from Lactococcus lactis C660 had a growth inhibitory effect on Escherichia coli K92 that reached of 31%, 19% to Pseudomonas ..
  20. Nehal F, Sahnoun M, Smaoui S, Jaouadi B, Bejar S, Mohammed S. Characterization, high production and antimicrobial activity of exopolysaccharides from Lactococcus lactis F-mou. Microb Pathog. 2019;132:10-19 pubmed publisher
    A new exopolysaccharide (EPS) was produced by the Lactococcus lactis F-mou strain (LT898177.1) isolated from the Sahrawi camel milk in the Bir-Naam region, Algeria...
  21. Sheng Y, Yang X, Lian Y, Zhang B, He X, Xu W, et al. Characterization of a cadmium resistance Lactococcus lactis subsp. lactis strain by antioxidant assays and proteome profiles methods. Environ Toxicol Pharmacol. 2016;46:286-291 pubmed publisher
    ..In this study, resistance properties of a newly isolated Lactococcus lactis subsp. lactis for cadmium were studied by antioxidant assays and proteomics analysis...
  22. Veith N, Feldman Salit A, Cojocaru V, Henrich S, Kummer U, Wade R. Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria. PLoS Comput Biol. 2013;9:e1003159 pubmed publisher
    ..We then made a kinetic model of Lactococcus lactis PYK to relate the activator predictions to the intracellular sugar-phosphate conditions in lactic acid ..
  23. Cahoon L, Freitag N. Identification of Conserved and Species-Specific Functions of the Listeria monocytogenes PrsA2 Secretion Chaperone. Infect Immun. 2015;83:4028-41 pubmed publisher
    ..subtilis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus mutans, Staphylococcus aureus, and Lactococcus lactis were examined for functional complementation of a variety of L...
  24. Saha P, Chassaing B, Yeoh B, Viennois E, Xiao X, Kennett M, et al. Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors. Inflamm Bowel Dis. 2017;23:1120-1132 pubmed publisher
    ..Murine Lcn2 was cloned into the pT1NX plasmid and transformed into Lactococcus lactis to generate L. lactis-expressing Lcn2 (Lactis-Lcn2) or the empty plasmid (Lactis-Con)...
  25. Zurita Turk M, Del Carmen S, Santos A, Pereira V, Cara D, Leclercq S, et al. Lactococcus lactis carrying the pValac DNA expression vector coding for IL-10 reduces inflammation in a murine model of experimental colitis. BMC Biotechnol. 2014;14:73 pubmed publisher
    ..We previously presented the development of an invasive strain of Lactococcus lactis (L...
  26. Garneau J, Sekulovic O, Dupuy B, Soutourina O, Monot M, Fortier L. High Prevalence and Genetic Diversity of Large phiCD211 (phiCDIF1296T)-Like Prophages in Clostridioides difficile. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..It shares morphological and genomic similarity with other large siphophages, like phage 949, infecting Lactococcus lactis, and phage c-st, infecting Clostridium botulinum A PhageTerm analysis indicated the presence of ..
  27. Lee M, Lee J, Nam Y, Lee J, Seo M, Yi S. Characterization of antimicrobial lipopeptides produced by Bacillus sp. LM7 isolated from chungkookjang, a Korean traditional fermented soybean food. Int J Food Microbiol. 2016;221:12-8 pubmed publisher
    ..and Listeria monocytogenes, but it did not inhibit lactic acid bacteria such as Lactobacillus plantarum and Lactococcus lactis subsp. Lactis...
  28. Kuda T, Kawahara M, Nemoto M, Takahashi H, Kimura B. In vitro antioxidant and anti-inflammation properties of lactic acid bacteria isolated from fish intestines and fermented fish from the Sanriku Satoumi region in Japan. Food Res Int. 2014;64:248-255 pubmed publisher
    ..The two other strains (S-SU2, 6) identified were Lactococcus lactis and Pediococcus pentosaceus. In these in vitro assays, Lc...
  29. Lee J, Parlane N, Rehm B, Buddle B, Heiser A. Engineering Mycobacteria for the Production of Self-Assembling Biopolyesters Displaying Mycobacterial Antigens for Use as a Tuberculosis Vaccine. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..engineered polyhydroxyalkanoate (PHA) biobeads that were produced in both Escherichia coli and Lactococcus lactis and displayed mycobacterial antigens were found to induce significant cell-mediated immune responses in ..
  30. Chamcha V, Jones A, Quigley B, Scott J, Amara R. Oral Immunization with a Recombinant Lactococcus lactis-Expressing HIV-1 Antigen on Group A Streptococcus Pilus Induces Strong Mucosal Immunity in the Gut. J Immunol. 2015;195:5025-34 pubmed publisher
    ..In this article, we explore the ability of an oral vaccination with a probiotic organism, Lactococcus lactis, to elicit HIV-specific immune responses in the mucosal and systemic compartments of BALB/c mice...
  31. Jounai K, Ikado K, Sugimura T, Ano Y, Braun J, Fujiwara D. Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells. PLoS ONE. 2012;7:e32588 pubmed publisher
    ..Detailed study of Lactococcus lactis subsp...
  32. Xin Y, Guo T, Mu Y, Kong J. Development of a counterselectable seamless mutagenesis system in lactic acid bacteria. Microb Cell Fact. 2017;16:116 pubmed publisher
    ..The pheS gene encoding phenylalanyl-tRNA synthetase alpha subunit was identified in Lactococcus lactis NZ9000 genome. When mutant pheS gene (pheS*) under the control of the Lc...
  33. Mustafa A, Kalyanasundram J, Sabidi S, Song A, Abdullah M, Abdul Rahim R, et al. Proof of concept in utilizing in-trans surface display system of Lactobacillus plantarum as mucosal tuberculosis vaccine via oral administration in mice. BMC Biotechnol. 2018;18:63 pubmed publisher
    ..Co-administration of an adjuvant consisting of Lactococcus lactis secreting mouse IL-12 (LcIL-12) with Lp ACERL was also investigated...
  34. Juturu V, Wu J. Microbial production of bacteriocins: Latest research development and applications. Biotechnol Adv. 2018;36:2187-2200 pubmed publisher
    ..the only bacteriocin that has got FDA approval for application as a food preservative, which is produced by Lactococcus lactis subsp. Lactis...
  35. SÅ‚awinska A, Siwek M, Bednarczyk M. Effects of synbiotics injected in ovo on regulation of immune-related gene expression in adult chickens. Am J Vet Res. 2014;75:997-1003 pubmed publisher
    ..30 Green-legged Partridgelike chickens. On incubation day 12, eggs were injected with 3 synbiotics (Lactococcus lactis subsp lactis IBB SL1 with raffinose family oligosaccharides [RFOs; S1], Lactococcus lactis subsp cremoris ..
  36. Lei H, Peng X, Ouyang J, Zhao D, Jiao H, Shu H, et al. Protective immunity against influenza H5N1 virus challenge in chickens by oral administration of recombinant Lactococcus lactis expressing neuraminidase. BMC Vet Res. 2015;11:85 pubmed publisher
    ..The aim of this study was to evaluate the protective immunity of NA based on Lactococcus lactis (L.lactis) expression system against homologous H5N1 virus challenge in a chicken model. L...
  37. Ai C, Zhang Q, Ren C, Wang G, Liu X, Tian F, et al. Genetically engineered Lactococcus lactis protect against house dust mite allergy in a BALB/c mouse model. PLoS ONE. 2014;9:e109461 pubmed publisher
    ..Therefore, we sought to investigate how recombinant major dust mite allergen Der p2-expressing Lactococcus lactis as a mucosal vaccine induced the immune tolerance against house dust mite allergy in a mouse model...
  38. Parente E, Guidone A, Matera A, De Filippis F, Mauriello G, Ricciardi A. Microbial community dynamics in thermophilic undefined milk starter cultures. Int J Food Microbiol. 2016;217:59-67 pubmed publisher
    ..thermophilus populations. L. delbrueckii and Lactococcus lactis bacteriophages were below the detection limit of the method used and high titres of cos type S...
  39. Guo T, Zhang C, Liu W, Wang S, Kong J. Functional analysis of the N-terminal region of endolysin Lyb5 encoded by Lactobacillus fermentum bacteriophage φPYB5. Int J Food Microbiol. 2015;203:1-7 pubmed publisher
    ..Similar results were obtained using Lactococcus lactis as a host to express Lyb5...
  40. Chen J, Shen J, Solem C, Jensen P. A New Type of YumC-Like Ferredoxin (Flavodoxin) Reductase Is Involved in Ribonucleotide Reduction. MBio. 2015;6:e01132-15 pubmed publisher
    The trxB2 gene, which is annotated as a thioredoxin reductase, was found to be essential for growth of Lactococcus lactis in the presence of oxygen...
  41. Roeffen W, Theisen M, van de Vegte Bolmer M, van Gemert G, Arens T, Andersen G, et al. Transmission-blocking activity of antibodies to Plasmodium falciparum GLURP.10C chimeric protein formulated in different adjuvants. Malar J. 2015;14:443 pubmed publisher
    ..The recombinant fusion protein R0.10C was produced in Lactococcus lactis and purified by affinity-chromatography on a monoclonal antibody (mAb 85RF45...
  42. Meng F, Zhao H, Zhang C, Lu F, Bie X, Lu Z. Expression of a novel bacteriocin-the plantaricin Pln1-in Escherichia coli and its functional analysis. Protein Expr Purif. 2016;119:85-93 pubmed publisher
    ..activity against gram-positive bacteria such as Micrococcus luteus CMCC 63202, Staphylococcus epidermidis, Lactococcus lactis NZ3900, Lactobacillus paracasei CICC 20241, and Listeria innocua CICC 10417...
  43. Dong X, Wang Y, Yang F, Zhao S, Tian B, Li T. Expression of lycopene biosynthesis genes fused in line with Shine-Dalgarno sequences improves the stress-tolerance of Lactococcus lactis. Biotechnol Lett. 2017;39:65-70 pubmed publisher
    Lycopene biosynthetic genes from Deinococcus radiodurans were co-expressed in Lactococcus lactis to produce lycopene and improve its tolerance to stress. Lycopene-related genes from D...
  44. Cirković I, Bozic D, Draganic V, Lozo J, Berić T, Kojic M, et al. Licheniocin 50.2 and Bacteriocins from Lactococcus lactis subsp. lactis biovar. diacetylactis BGBU1-4 Inhibit Biofilms of Coagulase Negative Staphylococci and Listeria monocytogenes Clinical Isolates. PLoS ONE. 2016;11:e0167995 pubmed publisher
    ..2 from Bacillus licheniformis VPS50.2 and crude extract of bacteriocins produced by Lactococcus lactis subsp. lactis biovar...
  45. Bora S, Keot J, Das S, Sarma K, Barooah M. Metagenomics analysis of microbial communities associated with a traditional rice wine starter culture (Xaj-pitha) of Assam, India. 3 Biotech. 2016;6:153 pubmed publisher
    ..occurring LAB was Lactobacillus plantarum, Lactobacillus brevis, Leuconostoc lactis, Weissella cibaria, Lactococcus lactis, Weissella para mesenteroides, Leuconostoc pseudomesenteroides, etc...
  46. Beck B, Lee S, Kim D, Park J, Lee H, Kwon S, et al. A Lactococcus lactis BFE920 feed vaccine expressing a fusion protein composed of the OmpA and FlgD antigens from Edwardsiella tarda was significantly better at protecting olive flounder (Paralichthys olivaceus) from edwardsiellosis than single antige. Fish Shellfish Immunol. 2017;68:19-28 pubmed publisher
    ..lactis BFE920 expressing a fusion antigen composed of E. tarda OmpA and FlgD showed a strong protective effect against edwardsiellosis indicating this may be developed as an E. tarda feed vaccine. ..
  47. Loera Arias M, Villatoro Hernández J, Parga Castillo M, Salcido Montenegro A, Barboza Quintana O, Muñoz Maldonado G, et al. Secretion of biologically active human interleukin 22 (IL-22) by Lactococcus lactis. Biotechnol Lett. 2014;36:2489-94 pubmed publisher
    ..We generated a Lactococcus lactis strain that secretes human IL-22 under the regulation of the nisin-inducible promoter...
  48. Rangel Colmenero B, Gomez Gutierrez J, Villatoro Hernández J, Zavala Flores L, Quistián Martínez D, Rojas Martínez A, et al. Enhancement of Ad-CRT/E7-mediated antitumor effect by preimmunization with L. lactis expressing HPV-16 E7. Viral Immunol. 2014;27:463-7 pubmed publisher
    ..We also demonstrated that immunization with Lactococcus lactis encoding HPV-16 E7 (Ll-E7) anchored to its surface induces significant HPV-16 E7-specific immune response...
  49. Dijkstra A, Alkema W, Starrenburg M, Hugenholtz J, van Hijum S, Bron P. Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness. Microb Cell Fact. 2014;13:148 pubmed publisher
    b>Lactococcus lactis is industrially employed to manufacture various fermented dairy products. The most cost-effective method for the preservation of L...
  50. Beigi M, Gauchenova E, Walter L, Waltzer S, Bonina F, Stillger T, et al. Regio- and Stereoselective Aliphatic-Aromatic Cross-Benzoin Reaction: Enzymatic Divergent Catalysis. Chemistry. 2016;22:13999-14005 pubmed publisher
    ..decarboxylase from Pseudomonas putida (PpBFD-L461A), branched-chain 2-keto acid decarboxylase from Lactococcus lactis (LlKdcA) and a variant of pyruvate decarboxylase from Acetobacter pasteurianus (ApPDC-E469G), was studied...
  51. Kazemi R, Taheri Kafrani A, Motahari A, Kordesedehi R. Allergenicity reduction of bovine milk ?-lactoglobulin by proteolytic activity of lactococcus lactis BMC12C and BMC19H isolated from Iranian dairy products. Int J Biol Macromol. 2018;112:876-881 pubmed publisher
    ..Accordingly, these isolates can reduce the immunoreactivity of bovine milk proteins, which can be helpful for the production of low-allergic dairy products. ..
  52. Kasmi M, Elleuch L, Dahmeni A, Hamdi M, Trabelsi I, Snoussi M. Novel approach for the use of dairy industry wastes for bacterial growth media production. J Environ Manage. 2018;212:176-185 pubmed publisher
    ..and identified bacterial strains from dairy wastes (Lactobacillus paracasei, Lactobacillus plantarum, Lactococcus lactis and Lactobacillus brevis) were investigated for their ability to grow on the formulated media...
  53. Børsting M, Qvist K, Brockmann E, Vindeløv J, Pedersen T, Vogensen F, et al. Classification of Lactococcus lactis cell envelope proteinase based on gene sequencing, peptides formed after hydrolysis of milk, and computer modeling. J Dairy Sci. 2015;98:68-77 pubmed publisher
    b>Lactococcus lactis strains depend on a proteolytic system for growth in milk to release essential AA from casein...
  54. Gabed N, Yang M, Bey Baba Hamed M, Drici H, Gross R, Dandekar T, et al. Draft Genome Sequence of the Moderately Heat-Tolerant Lactococcus lactis subsp. lactis bv. diacetylactis Strain GL2 from Algerian Dromedary Milk. Genome Announc. 2015;3: pubmed publisher
    b>Lactococcus lactis subsp. lactis bv. diacetylactis GL2 is a moderately thermotolerant lactic acid bacterium isolated from dromedary raw milk...
  55. Kuipers A, de Vries L, de Vries M, Rink R, Bosma T, Moll G. Semi-microbiological synthesis of an active lysinoalanine-bridged analog of glucagon-like-peptide-1. Peptides. 2017;91:33-39 pubmed publisher
    ..Here we investigated whether GLP-1 analogs expressed in Lactococcus lactis could be substrates for modification and export by the nisin dehydratase and transporter enzyme...
  56. Abdollahi S, Ghahremani M, Setayesh N, Samadi N. Listeria monocytogenes and Salmonella enterica affect the expression of nisin gene and its production by Lactococcus lactis. Microb Pathog. 2018;123:28-35 pubmed publisher
    The Lactococcus lactis is known as a probiotic bacterium and also as a producer of nisin. Nisin has been approved by related legal agencies to be used as an antimicrobial peptide in food preservation. In fact, the L...
  57. Mustopa A, Mariyah S, Fatimah -, Budiarti S, Murtiyaningsih H, Alfisyahrin W. Construction, heterologous expression, partial purification, and in vitro cytotoxicity of the recombinant plantaricin E produced by Lactococcus lactis against Enteropathogenic Escherichia coli K.1.1 and human cervical carcinoma (HeLa) cells. Mol Biol Rep. 2018;45:1235-1244 pubmed publisher
    ..E (Pln E), a recombinant bacteriocin, has been successfully constructed and produced by a GRAS host, Lactococcus lactis. A polymerase chain reaction (PCR) overlapping technique has been used to construct a ligation of signal ..
  58. Velly H, Renault P, Abraham A, Loux V, Delacroix Buchet A, Fonseca F, et al. Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis subsp. lactis TOMSC161, Isolated from a Nonscalded Curd Pressed Cheese. Genome Announc. 2014;2: pubmed publisher
    b>Lactococcus lactis is a lactic acid bacterium used in the production of many fermented foods, such as dairy products. Here, we report the genome sequence of L. lactis subsp. lactis TOMSC161, isolated from nonscalded curd pressed cheese...
  59. Divya J, Nampoothiri K. Encapsulated Lactococcus lactis with enhanced gastrointestinal survival for the development of folate enriched functional foods. Bioresour Technol. 2015;188:226-30 pubmed publisher
    Two lactic acid bacteria (LAB) isolated from cow's milk were identified as Lactococcus lactis strains and designated as L. lactis CM22 and L. lactis CM28...
  60. Asurmendi P, Garcia M, Ruiz F, Dalcero A, Pascual L, Barberis L. Biological control of AFB1-producing Aspergillus section Flavi strains isolated from brewer's grains, alternative feed intended for swine production in Argentina. J Environ Sci Health B. 2016;51:477-81 pubmed publisher
    ..The isolates Lactobacillus brevis B20, P. pentosaceus B86, Lactococcus lactis subsp. lactis B87, L. brevis B131, and Lactobacillus sp...
  61. del Rio B, Linares D, Ladero V, Redruello B, Fernandez M, Martín M, et al. Putrescine biosynthesis in Lactococcus lactis is transcriptionally activated at acidic pH and counteracts acidification of the cytosol. Int J Food Microbiol. 2016;236:83-9 pubmed publisher
    b>Lactococcus lactis subsp. cremoris CECT 8666 is a lactic acid bacterium that synthesizes the biogenic amine putrescine from agmatine via the agmatine deiminase (AGDI) pathway. The AGDI genes cluster includes aguR...
  62. Zhao Y, Wang Y, Song Z, Shan C, Zhu R, Liu F. Development of a simple, low-cost and eurytopic medium based on Pleurotus eryngii for lactic acid bacteria. AMB Express. 2016;6:65 pubmed publisher
    ..buffers, tween 80, MgSO4·7H2O, MnSO4·4H2O, CuSO4·5H2O, riboflavin and ascorbic acid on the growth of Lactococcus lactis subsp. lactis SLPE1-3...
  63. KELLEHER P, Bottacini F, Mahony J, Kilcawley K, van Sinderen D. Comparative and functional genomics of the Lactococcus lactis taxon; insights into evolution and niche adaptation. BMC Genomics. 2017;18:267 pubmed publisher
    b>Lactococcus lactis is among the most widely studied lactic acid bacterial species due to its long history of safe use and economic importance to the dairy industry, where it is exploited as a starter culture in cheese production...
  64. Ribeiro Júnior J, de Oliveira A, Silva F, Tamanini R, de Oliveira A, Beloti V. The main spoilage-related psychrotrophic bacteria in refrigerated raw milk. J Dairy Sci. 2018;101:75-83 pubmed publisher
    ..Among the proteolytic species, more isolated by this study were Lactococcus lactis (27.3%), Enterobacter kobei (14.8%), Serratia ureilytica (8%), Aerococcus urinaeequi (6...
  65. Vandera E, Tsirka G, Kakouri A, Koukkou A, Samelis J. Approaches for enhancing in situ detection of enterocin genes in thermized milk, and selective isolation of enterocin-producing Enterococcus faecium from Baird-Parker agar. Int J Food Microbiol. 2018;281:23-31 pubmed publisher
    ..The multiple enterocin-producing (m-Ent+) Enterococcus faecium KE82 and the nisin A-producing Lactococcus lactis subsp. cremoris M104 served as bacteriocin-positive inocula in separate TM treatments...
  66. Cesselin B, Garrigues C, Pedersen M, Roussel C, Gruss A, Gaudu P. Task Distribution between Acetate and Acetoin Pathways to Prolong Growth in Lactococcus lactis under Respiration Conditions. Appl Environ Microbiol. 2018;: pubmed publisher
    i>Lactococcus lactis is the main bacterium used for food fermentation and is a candidate for probiotic development...
  67. Korsak N, Taminiau B, Leclercq M, Nezer C, Crèvecoeur S, Ferauche C, et al. Short communication: Evaluation of the microbiota of kefir samples using metagenetic analysis targeting the 16S and 26S ribosomal DNA fragments. J Dairy Sci. 2015;98:3684-9 pubmed publisher
    ..the presence of 20 main bacterial species, with a dominance of the following: Lactobacillus kefiranofaciens, Lactococcus lactis ssp...
  68. Fortier L, Bouchard J, Moineau S. Expression and site-directed mutagenesis of the lactococcal abortive phage infection protein AbiK. J Bacteriol. 2005;187:3721-30 pubmed publisher
    Abortive infection mechanisms of Lactococcus lactis form a heterogeneous group of phage resistance systems that act after early phage gene expression...
  69. Szymczak P, Janzen T, Neves A, Kot W, Hansen L, Lametsch R, et al. Novel Variants of Streptococcus thermophilus Bacteriophages Are Indicative of Genetic Recombination among Phages from Different Bacterial Species. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..Sequencing analysis revealed the genetic similarity of CHPC577 and CHPC926 with a subgroup of Lactococcus lactis P335 phages. Phage CHPC1151 was closely related to the atypical S...
  70. Breyner N, Michon C, de Sousa C, Vilas Boas P, Chain F, Azevedo V, et al. Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-?B Pathway. Front Microbiol. 2017;8:114 pubmed publisher
    ..To study the effect of MAM we orally administered to the mice a Lactococcus lactis strain carrying a plasmid containing the cDNA of MAM under the control of a eukaryotic promoter. L...
  71. Gao X, Zhou X, Wang H, Lv N, Liu Y, Guo J. Effects of heme oxygenase-1 recombinant Lactococcus lactis on the intestinal barrier of hemorrhagic shock rats. Braz J Med Biol Res. 2017;50:e5601 pubmed publisher
    This study aimed to investigate the effects of heme oxygenase-1 recombinant Lactococcus lactis (LL-HO-1) on the intestinal barrier of rats with hemorrhagic shock...
  72. Jounai K, Sugimura T, Morita Y, Ohshio K, Fujiwara D. Administration of Lactococcus lactis strain Plasma induces maturation of plasmacytoid dendritic cells and protection from rotavirus infection in suckling mice. Int Immunopharmacol. 2018;56:205-211 pubmed publisher
    b>Lactococcus lactis subsp. lactis JCM 5805 (LC-Plasma) is a strain of lactic acid bacteria (LAB) that activates murine and human plasmacytoid dendritic cells (pDCs) to express interferons (IFNs)...
  73. King M, Boes C, Kunji E. Membrane protein expression in Lactococcus lactis. Methods Enzymol. 2015;556:77-97 pubmed publisher
    The Gram-positive bacterium Lactococcus lactis has many properties that are ideal for the overproduction of membrane proteins in a functional form...
  74. Turgis M, Vu K, Millette M, Dupont C, Lacroix M. Influence of Environmental Factors on Bacteriocin Production by Human Isolates of Lactococcus lactis MM19 and Pediococcus acidilactici MM33. Probiotics Antimicrob Proteins. 2016;8:53-9 pubmed publisher
    The influence of temperature, initial pH, and carbon and nitrogen sources on bacteriocin secreted by Lactococcus lactis MM19 (MM19) and Pediococcus acidilactici MM33 (MM33) was evaluated...
  75. Léonard L, Husson F, Langella P, Châtel J, Saurel R. Aqueous two-phase system cold-set gelation using natural and recombinant probiotic lactic acid bacteria as a gelling agent. Colloids Surf B Biointerfaces. 2016;141:338-344 pubmed publisher
    ..i) Lactobacillus plantarum CNRZ1997 cells were found mainly in continuous alginate networks, whereas (ii) Lactococcus lactis cells were localized in protein microdomains...
  76. Vinogradov E, Sadovskaya I, Courtin P, Kulakauskas S, Grard T, Mahony J, et al. Determination of the cell wall polysaccharide and teichoic acid structures from Lactococcus lactis IL1403. Carbohydr Res. 2018;462:39-44 pubmed publisher
    In the lactic acid bacterium Lactococcus lactis, a cell wall polysaccharide (CWPS) is the bacterial receptor of the majority of infecting bacteriophages...
  77. van Mastrigt O, Gallegos Tejeda D, Kristensen M, Abee T, Smid E. Aroma formation during cheese ripening is best resembled by Lactococcus lactis retentostat cultures. Microb Cell Fact. 2018;17:104 pubmed publisher
    ..In this study, aroma formation by a dairy Lactococcus lactis was analysed as a function of the growth medium [milk, hydrolysed micellar casein isolate (MCI) and ..
  78. Nouaille S, Rault L, Jeanson S, Loubière P, Le Loir Y, Even S. Contribution of Lactococcus lactis reducing properties to the downregulation of a major virulence regulator in Staphylococcus aureus, the agr system. Appl Environ Microbiol. 2014;80:7028-35 pubmed publisher
    ..We had previously established the ability of Lactococcus lactis, a lactic acid bacterium widely used in the dairy industry, to downregulate a major staphylococcal virulence ..
  79. Eraclio G, Ricci G, Fortina M. Insertion sequence elements in Lactococcus garvieae. Gene. 2015;555:291-6 pubmed publisher
    ..Most of the insertion sequences in L. garvieae show substantial homology to the Lactococcus lactis elements, suggesting the movement of IS between these two species phylogenetically closely related...
  80. Bedford A, Chen T, Huynh E, Zhu C, Medeiros S, Wey D, et al. Epidermal growth factor containing culture supernatant enhances intestine development of early-weaned pigs in vivo: potential mechanisms involved. J Biotechnol. 2015;196-197:9-19 pubmed publisher
    We have previously generated epidermal factor expressing Lactococcus lactis (EGF-LL) using a bioengineering approach, and shown that EGF-LL fermentation supernatant enhanced newly weaned pigs growth...
  81. Ladero V, del Rio B, Linares D, Fernandez M, Mayo B, Martín M, et al. Draft Genome Sequence of the Putrescine-Producing Strain Lactococcus lactis subsp. lactis 1AA59. Genome Announc. 2015;3: pubmed publisher
    We report here the 2,576,542-bp genome annotated draft assembly sequence of Lactococcus lactis subsp. lactis 1AA59...
  82. Noens E, Kaczmarek M, Żygo M, Lolkema J. ArcD1 and ArcD2 Arginine/Ornithine Exchangers Encoded in the Arginine Deiminase Pathway Gene Cluster of Lactococcus lactis. J Bacteriol. 2015;197:3545-53 pubmed publisher
    The arginine deiminase (ADI) pathway gene cluster in Lactococcus lactis contains two copies of a gene encoding an l-arginine/l-ornithine exchanger, the arcD1 and arcD2 genes...
  83. Li S, Ramelot T, Kennedy M, Liu M, Yang Y. Chemical shift assignments of the homodimer protein SP_0782 (7-79) from Streptococcus pneumoniae. Biomol NMR Assign. 2016;10:341-4 pubmed publisher
    ..The ssDNA binding of the homolog YdbC from Lactococcus lactis was previously characterized when bound to a 20-mer of pyridine-rich ssDNA, sharing an overall similar ..
  84. Breüner A, Frees D, Varmanen P, Boguta A, Hammer K, Martinussen J, et al. Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis. Microbiology. 2016;162:1829-1839 pubmed publisher
    We analysed the response of the model bacterium Lactococcus lactis to abrupt depletion of glucose after several generations of exponential growth...
  85. Zhu L, Cronan J. The conserved modular elements of the acyl carrier proteins of lipid synthesis are only partially interchangeable. J Biol Chem. 2015;290:13791-9 pubmed publisher
    ..However, the AcpAs of Lactococcus lactis and Enterococcus faecalis were inactive. Both failed to support growth of an E. coli acpP mutant strain...
  86. Chikindas M, Emond E, Haandrikman A, Kok J, Leenhouts K, Pandian S, et al. Heterologous Processing and Export of the Bacteriocins Pediocin PA-1 and Lactococcin A in Lactococcus Lactis: A Study with Leader Exchange. Probiotics Antimicrob Proteins. 2010;2:66-76 pubmed publisher
    ..These results show the potential of the lactococcin LcnC/LcnD machinery as a maturation system for peptides carrying double-glycine-type amino-terminal leaders. ..
  87. Costas Malvido M, Alonso González E, Pérez Guerra N. Nisin production in realkalized fed-batch cultures in whey with feeding with lactose- or glucose-containing substrates. Appl Microbiol Biotechnol. 2016;100:7899-908 pubmed publisher
    Nisin production by Lactococcus lactis CECT 539 was followed in batch cultures in whey supplemented with different concentrations of glucose and in two realkalized fed-batch fermentations in unsupplemented whey, which were fed, ..
  88. Ge X, Teng K, Wang J, Zhao F, Wang F, Zhang J, et al. Ligand determinants of nisin for its induction activity. J Dairy Sci. 2016;99:5022-5031 pubmed publisher
    ..Improving nisin production is important for its enormous applications. Nisin A is produced in Lactococcus lactis and its biosynthesis is induced through the regulation of the 2-component system NisKR...
  89. Carvalho R, Breyner N, Menezes Garcia Z, Rodrigues N, Lemos L, Maioli T, et al. Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis. Microb Cell Fact. 2017;16:27 pubmed publisher
    ..Indeed, it was demonstrated that a recombinant strain of Lactococcus lactis expressing human PAP (LL-PAP) could prevent and improve murine DNBS-induced colitis, an inflammatory bowel ..
  90. Cao L, Liang D, Hao P, Song Q, Xue E, Caiyin Q, et al. The increase of O-acetylation and N-deacetylation in cell wall promotes acid resistance and nisin production through improving cell wall integrity in Lactococcus lactis. J Ind Microbiol Biotechnol. 2018;45:813-825 pubmed publisher
    ..related to bacterial robustness and adsorption capacity, playing crucial roles in nisin production in Lactococcus lactis. Peptidoglycan (PG), the essential component of cell wall, is usually modified with MurNAc O-acetylation and ..
  91. López González M, Campelo A, Picon A, Rodriguez A, Martinez B. Resistance to bacteriocin Lcn972 improves oxygen tolerance of Lactococcus lactis IPLA947 without compromising its performance as a dairy starter. BMC Microbiol. 2018;18:76 pubmed publisher
    b>Lactococcus lactis is the main component of the mesophilic starters used in cheese manufacture. The success of milk fermentation relies on the viability and metabolic activity of the starter bacteria...
  92. Jahns A, Schafer A, Geis A, Teuber M. Identification, cloning and sequencing of the replication region of Lactococcus lactis ssp. lactis biovar. diacetylactis Bu2 citrate plasmid pSL2. FEMS Microbiol Lett. 1991;64:253-8 pubmed
    The replication region of the 7.8 kilobase (kb) citrate plasmid pSL2 from Lactococcus lactis ssp. lactis biovar. diacetylactis Bu2 was identified...