Bacillus subtilis subsp. subtilis str. 168

Summary

Alias: Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700

Top Publications

  1. Patrick J, Kearns D. MinJ (YvjD) is a topological determinant of cell division in Bacillus subtilis. Mol Microbiol. 2008;70:1166-79 pubmed publisher
    ..MinJ itself localized to cell poles in a manner that was dependent on DivIVA. MinJ is conserved in other low G+C Gram-positive bacteria and may be an important component of cell division site selection in these organisms. ..
  2. Schirner K, Errington J. The cell wall regulator {sigma}I specifically suppresses the lethal phenotype of mbl mutants in Bacillus subtilis. J Bacteriol. 2009;191:1404-13 pubmed publisher
    ..We found that the construction of a triple mutant lacking all three actin homologues became possible in the rsgI background. Triple mutant cells are spherical, but no significant defect in chromosome segregation was detected. ..
  3. Doherty G, Fogg M, Wilkinson A, Lewis P. Small subunits of RNA polymerase: localization, levels and implications for core enzyme composition. Microbiology. 2010;156:3532-43 pubmed publisher
    ..The ? subunit may be required for RNAP assembly and subsequently be turned over at different rates or it may play roles in Gram-negative bacteria that are performed by other factors in Gram-positives. ..
  4. Gündoğdu M, Kawai Y, Pavlendova N, Ogasawara N, Errington J, Scheffers D, et al. Large ring polymers align FtsZ polymers for normal septum formation. EMBO J. 2011;30:617-26 pubmed publisher
    ..We propose that SepF rings are required for the regular arrangement of FtsZ filaments. Absence of this ordered state could explain the grossly distorted septal morphologies seen in sepF mutants. ..
  5. Ostrowski A, Mehert A, Prescott A, Kiley T, Stanley Wall N. YuaB functions synergistically with the exopolysaccharide and TasA amyloid fibers to allow biofilm formation by Bacillus subtilis. J Bacteriol. 2011;193:4821-31 pubmed publisher
    ..We hypothesize that YuaB functions synergistically with the known components of the biofilm matrix to facilitate the assembly of the biofilm matrix. ..
  6. Cardenas P, Carrasco B, Defeu Soufo C, César C, Herr K, Kaufenstein M, et al. RecX facilitates homologous recombination by modulating RecA activities. PLoS Genet. 2012;8:e1003126 pubmed publisher
    ..RecX, by modulating the "length or packing" of a RecA filament, facilitates the initiation of recombination and increases recombination across species. ..
  7. Hastie J, Williams K, Ellermeier C. The activity of ?V, an extracytoplasmic function ? factor of Bacillus subtilis, is controlled by regulated proteolysis of the anti-? factor RsiV. J Bacteriol. 2013;195:3135-44 pubmed publisher
    ..Collectively, these data provide evidence that the mechanism for ?(V) activation in B. subtilis is controlled by regulated intramembrane proteolysis (RIP) and requires the site 2 protease RasP. ..
  8. Bramkamp M, Emmins R, Weston L, Donovan C, Daniel R, Errington J. A novel component of the division-site selection system of Bacillus subtilis and a new mode of action for the division inhibitor MinCD. Mol Microbiol. 2008;70:1556-69 pubmed publisher
    ..The results support a model in which the main function of the Min system lies in allowing only a single round of division per cell cycle, and that MinCD acts at multiple levels to prevent inappropriate division. ..
  9. Donovan C, Bramkamp M. Characterization and subcellular localization of a bacterial flotillin homologue. Microbiology. 2009;155:1786-99 pubmed publisher
    ..Our results indicate that YuaG is involved in the early stage of spore development, probably playing a role in the signalling cascade at the onset of sporulation. ..

More Information

Publications106 found, 100 shown here

  1. Chi B, Kobayashi K, Albrecht D, Hecker M, Antelmann H. The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis. J Bacteriol. 2010;192:4571-81 pubmed publisher
    ..Redox regulation of CatR occurs independently of YodB, and no protein interaction was detected between CatR and YodB in vivo using protein cross-linking and mass spectrometry. ..
  2. Elsholz A, Hempel K, Pöther D, Becher D, Hecker M, Gerth U. CtsR inactivation during thiol-specific stress in low GC, Gram+ bacteria. Mol Microbiol. 2011;79:772-85 pubmed publisher
    ..Moreover, we show that in those low GC, Gram+ bacteria, which lack the McsA/McsB complex, the Zn finger protein ClpE is able to sense and respond to oxidative stress, also resulting in CtsR inactivation. ..
  3. Bürmann F, Shin H, Basquin J, Soh Y, Giménez Oya V, Kim Y, et al. An asymmetric SMC-kleisin bridge in prokaryotic condensin. Nat Struct Mol Biol. 2013;20:371-9 pubmed publisher
    ..We define a molecular mechanism that ensures asymmetric assembly, and we conclude that the basic architecture of SMC-kleisin rings evolved before the emergence of eukaryotes. ..
  4. Morinaga T, Ashida H, Yoshida K. Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis. Microbiology. 2010;156:1538-46 pubmed publisher
    ..The physiological role of IolW remains unclear, but it may be capable of producing SI from SIS with NADPH oxidation. ..
  5. Jers C, Pedersen M, Paspaliari D, Schütz W, Johnsson C, Soufi B, et al. Bacillus subtilis BY-kinase PtkA controls enzyme activity and localization of its protein substrates. Mol Microbiol. 2010;77:287-99 pubmed publisher
    ..Our results confirm that PtkA can control enzyme activity of its substrates in some cases, but also reveal a new mode of action for PtkA, namely ensuring correct cellular localization of its targets. ..
  6. McLoon A, Guttenplan S, Kearns D, Kolter R, Losick R. Tracing the domestication of a biofilm-forming bacterium. J Bacteriol. 2011;193:2027-34 pubmed publisher
    ..Thus, domestication of B. subtilis involved the accumulation of four mutations and the loss of a plasmid-borne gene. ..
  7. Guariglia Oropeza V, Helmann J. Bacillus subtilis ?(V) confers lysozyme resistance by activation of two cell wall modification pathways, peptidoglycan O-acetylation and D-alanylation of teichoic acids. J Bacteriol. 2011;193:6223-32 pubmed publisher
    ..Thus, we suggest that ?(V) confers lysozyme resistance by the activation of two cell wall modification pathways: O-acetylation of peptidoglycan catalyzed by OatA and D-alanylation of teichoic acids by DltABCDE. ..
  8. Garg S, Kommineni S, Henslee L, Zhang Y, Zuber P. The YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of Spx. J Bacteriol. 2009;191:1268-77 pubmed publisher
    ..In conclusion, YjbH is proposed to be an adaptor for ClpXP-catalyzed Spx degradation, and a model of YjbH redox control involving Zn dissociation is presented. ..
  9. Redko Y, Condon C. Ribosomal protein L3 bound to 23S precursor rRNA stimulates its maturation by Mini-III ribonuclease. Mol Microbiol. 2009;71:1145-54 pubmed publisher
    ..We also discuss the potential implication of using ribosomal protein cofactors in rRNA processing for ribosome quality control. ..
  10. Kawai Y, Daniel R, Errington J. Regulation of cell wall morphogenesis in Bacillus subtilis by recruitment of PBP1 to the MreB helix. Mol Microbiol. 2009;71:1131-44 pubmed publisher
    ..Our results suggest that MreB filaments associate directly with the peptidoglycan biosynthetic machinery in B. subtilis as part of the mechanism that brings about controlled cell elongation. ..
  11. Natori Y, Tagami K, Murakami K, Yoshida S, Tanigawa O, Moh Y, et al. Transcription activity of individual rrn operons in Bacillus subtilis mutants deficient in (p)ppGpp synthetase genes, relA, yjbM, and ywaC. J Bacteriol. 2009;191:4555-61 pubmed publisher
  12. Bisicchia P, Lioliou E, Noone D, Salzberg L, Botella E, Hübner S, et al. Peptidoglycan metabolism is controlled by the WalRK (YycFG) and PhoPR two-component systems in phosphate-limited Bacillus subtilis cells. Mol Microbiol. 2010;75:972-89 pubmed publisher
    ..Therefore, we conclude that peptidoglycan metabolism is controlled by both WalRK and PhoPR in phosphate-limited B. subtilis cells. ..
  13. Chumsakul O, Takahashi H, Oshima T, Hishimoto T, Kanaya S, Ogasawara N, et al. Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation. Nucleic Acids Res. 2011;39:414-28 pubmed publisher
    ..Surprisingly, most AbrB/Abh binding events had no impact on transcription, suggesting an interesting possibility that AbrB/Abh binding is analogous to nucleoid-associated protein binding in Escherichia coli. ..
  14. Diethmaier C, Pietack N, Gunka K, Wrede C, Lehnik Habrink M, Herzberg C, et al. A novel factor controlling bistability in Bacillus subtilis: the YmdB protein affects flagellin expression and biofilm formation. J Bacteriol. 2011;193:5997-6007 pubmed publisher
    ..Our studies demonstrate that lack of expression of SlrR, an antagonist of SinR, is responsible for the observed phenotypes. Overexpression of SlrR suppresses the effects of a ymdB mutation. ..
  15. de Vega M. The minimal Bacillus subtilis nonhomologous end joining repair machinery. PLoS ONE. 2013;8:e64232 pubmed publisher
  16. Land A, Luo Q, Levin P. Functional domain analysis of the cell division inhibitor EzrA. PLoS ONE. 2014;9:e102616 pubmed publisher
    ..Finally, chimeric analysis indicates that EzrA's transmembrane anchor plays a generic role: concentrating EzrA at the plasma membrane where presumably it can most effectively modulate FtsZ assembly. ..
  17. Sullivan N, Marquis K, Rudner D. Recruitment of SMC by ParB-parS organizes the origin region and promotes efficient chromosome segregation. Cell. 2009;137:697-707 pubmed publisher
    ..We propose a model in which recruitment of SMC to the origin by Spo0J-parS organizes the origin region and promotes efficient chromosome segregation. ..
  18. Anand B, Surana P, Bhogaraju S, Pahari S, Prakash B. Circularly permuted GTPase YqeH binds 30S ribosomal subunit: Implications for its role in ribosome assembly. Biochem Biophys Res Commun. 2009;386:602-6 pubmed publisher
    ..Further, S5, a ribosomal protein which participates during the initial stages of 30S assembly, was found to promote GTP hydrolysis and RNA binding activities of YqeH. ..
  19. Saller M, Fusetti F, Driessen A. Bacillus subtilis SpoIIIJ and YqjG function in membrane protein biogenesis. J Bacteriol. 2009;191:6749-57 pubmed publisher
    ..These data demonstrate that the Bacillus Oxa1p homologs have a role in membrane protein biogenesis rather than in protein secretion. ..
  20. Murray E, Strauch M, Stanley Wall N. SigmaX is involved in controlling Bacillus subtilis biofilm architecture through the AbrB homologue Abh. J Bacteriol. 2009;191:6822-32 pubmed publisher
    ..Furthermore, Abh is shown to activate transcription from the promoter of the eps operon through its control of SlrR. These findings add to the increasingly complex transcriptional network that controls biofilm formation by B. subtilis. ..
  21. Rivas Castillo A, Yasbin R, Robleto E, Nicholson W, Pedraza Reyes M. Role of the Y-family DNA polymerases YqjH and YqjW in protecting sporulating Bacillus subtilis cells from DNA damage. Curr Microbiol. 2010;60:263-7 pubmed publisher
    ..subtilis cells and contributes in processing spontaneous and artificially induced genetic damage, which is apparently required for an efficient sporulation process. ..
  22. Avila Perez M, van der Steen J, Kort R, Hellingwerf K. Red light activates the sigmaB-mediated general stress response of Bacillus subtilis via the energy branch of the upstream signaling cascade. J Bacteriol. 2010;192:755-62 pubmed publisher
    ..These results are confirmed by transcriptome analyses, which show that both light effects result in upregulation of the sigma(B) regulon, with minimal activation of other responses. ..
  23. Ho T, Hastie J, Intile P, Ellermeier C. The Bacillus subtilis extracytoplasmic function ? factor ?(V) is induced by lysozyme and provides resistance to lysozyme. J Bacteriol. 2011;193:6215-22 pubmed publisher
    ..In addition, we show that two ECF ? factor-regulated genes, dltA and pbpX, are required for lysozyme resistance. Thus, we have identified three independent mechanisms which B. subtilis utilizes to avoid killing by lysozyme. ..
  24. Castaing J, Nagy A, Anantharaman V, Aravind L, Ramamurthi K. ATP hydrolysis by a domain related to translation factor GTPases drives polymerization of a static bacterial morphogenetic protein. Proc Natl Acad Sci U S A. 2013;110:E151-60 pubmed publisher
  25. Olson A, Liu F, Tucker A, Goshe M, Cavanagh J. Chemical crosslinking and LC/MS analysis to determine protein domain orientation: application to AbrB. Biochem Biophys Res Commun. 2013;431:253-7 pubmed publisher
  26. Duman R, Ishikawa S, Celik I, Strahl H, Ogasawara N, Troć P, et al. Structural and genetic analyses reveal the protein SepF as a new membrane anchor for the Z ring. Proc Natl Acad Sci U S A. 2013;110:E4601-10 pubmed publisher
    ..These helices prefer positively curved membranes due to relaxed lipid density; therefore this type of membrane anchor may assist in keeping the Z ring positioned at the strongly curved leading edge of the developing septum. ..
  27. Soufo C, Soufo H, Noirot Gros M, Steindorf A, Noirot P, Graumann P. Cell-cycle-dependent spatial sequestration of the DnaA replication initiator protein in Bacillus subtilis. Dev Cell. 2008;15:935-41 pubmed publisher
    ..We propose that DnaA colocalization with origins is specific to the time of initiation, and that replisome/YabA-mediated spatial sequestration of DnaA prevents inappropriate reinitiation of DNA replication. ..
  28. Winkelman J, Blair K, Kearns D. RemA (YlzA) and RemB (YaaB) regulate extracellular matrix operon expression and biofilm formation in Bacillus subtilis. J Bacteriol. 2009;191:3981-91 pubmed publisher
    ..Both proteins are required for the activation of the matrix biosynthesis operons and appear to act in parallel to SinR and two other known biofilm regulators, AbrB and DegU. ..
  29. Kawai Y, Asai K, Errington J. Partial functional redundancy of MreB isoforms, MreB, Mbl and MreBH, in cell morphogenesis of Bacillus subtilis. Mol Microbiol. 2009;73:719-31 pubmed publisher
  30. Ogura M, Tsukahara K. Autoregulation of the Bacillus subtilis response regulator gene degU is coupled with the proteolysis of DegU-P by ClpCP. Mol Microbiol. 2010;75:1244-59 pubmed publisher
    ..We confirmed that DegU-P was degraded preferentially using an in vitro ClpCP degradation system. Furthermore, a mutational analysis showed that the N-terminal region of DegU is important for proteolysis. ..
  31. Grainger W, Machón C, Scott D, Soultanas P. DnaB proteolysis in vivo regulates oligomerization and its localization at oriC in Bacillus subtilis. Nucleic Acids Res. 2010;38:2851-64 pubmed publisher
    ..It encompasses an area from the middle of dnaA to the end of yaaA that includes the AT-rich region melted during the initiation stage of DNA replication. ..
  32. Lee B, Park E, Lee K, Jeon H, Sung K, Paulsen H, et al. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nat Struct Mol Biol. 2010;17:471-8 pubmed publisher
  33. Guttenplan S, Blair K, Kearns D. The EpsE flagellar clutch is bifunctional and synergizes with EPS biosynthesis to promote Bacillus subtilis biofilm formation. PLoS Genet. 2010;6:e1001243 pubmed publisher
    ..Thus, the transition from motility to biofilm formation may be governed by a single bifunctional enzyme. ..
  34. Soufo H, Graumann P. Bacillus subtilis MreB paralogues have different filament architectures and lead to shape remodelling of a heterologous cell system. Mol Microbiol. 2010;78:1145-58 pubmed publisher
  35. Parashar V, Mirouze N, DUBNAU D, Neiditch M. Structural basis of response regulator dephosphorylation by Rap phosphatases. PLoS Biol. 2011;9:e1000589 pubmed publisher
  36. Hashimoto M, Ooiwa S, Sekiguchi J. Synthetic lethality of the lytE cwlO genotype in Bacillus subtilis is caused by lack of D,L-endopeptidase activity at the lateral cell wall. J Bacteriol. 2012;194:796-803 pubmed publisher
    ..The functions of LytE and CwlO in cell morphogenesis were discussed. ..
  37. Boonstra M, de Jong I, Scholefield G, Murray H, Kuipers O, Veening J. Spo0A regulates chromosome copy number during sporulation by directly binding to the origin of replication in Bacillus subtilis. Mol Microbiol. 2013;87:925-38 pubmed publisher
    ..Our data support the hypothesis that Spo0A directly controls DNA replication during sporulation by binding to oriC. ..
  38. Zhang Y, Zuber P. Requirement of the zinc-binding domain of ClpX for Spx proteolysis in Bacillus subtilis and effects of disulfide stress on ClpXP activity. J Bacteriol. 2007;189:7669-80 pubmed
    ..The results are consistent with the hypothesis that inhibition of ClpXP by disulfide stress is due to structural changes to the N-terminal ZBD of ClpX...
  39. Leelakriangsak M, Huyen N, Töwe S, Van Duy N, Becher D, Hecker M, et al. Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis. Mol Microbiol. 2008;67:1108-24 pubmed publisher
    ..Thus, both azoreductases that are controlled by different regulatory mechanisms have common functions in quinone and azo-compound reduction to protect cells against the thiol reactivity of electrophiles...
  40. Dubois J, Kouwen T, Schurich A, Reis C, Ensing H, Trip E, et al. Immunity to the bacteriocin sublancin 168 Is determined by the SunI (YolF) protein of Bacillus subtilis. Antimicrob Agents Chemother. 2009;53:651-61 pubmed publisher
    ..Thus, the bulk of the protein faces the cytoplasm of B. subtilis. This topology has not yet been reported for known bacteriocin producer immunity proteins, which implies that SunI belongs to a novel class of bacteriocin antagonists...
  41. Nguyen T, Eiamphungporn W, Mäder U, Liebeke M, Lalk M, Hecker M, et al. Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR). Mol Microbiol. 2009;71:876-94 pubmed publisher
    ..We speculate that AdhR is redox-regulated via thiol-(S)-alkylation by aldehydes and that AdhA and YraA are specifically involved in reduction of aldehydes and degradation or repair of damaged thiol-containing proteins respectively...
  42. Gruber S, Errington J. Recruitment of condensin to replication origin regions by ParB/SpoOJ promotes chromosome segregation in B. subtilis. Cell. 2009;137:685-96 pubmed publisher
    ..Our results demonstrate a direct functional interaction between two widely conserved systems involved in chromosome replication and segregation...
  43. Singh P, Ramachandran G, Durán Alcalde L, Alonso C, Wu L, Meijer W. Inhibition of Bacillus subtilis natural competence by a native, conjugative plasmid-encoded comK repressor protein. Environ Microbiol. 2012;14:2812-25 pubmed publisher
    ..Finally, we discuss the possible role of the plasmid-located rok and its relatedness with other rok genes...
  44. Salzberg L, Powell L, Hokamp K, Botella E, Noone D, Devine K. The WalRK (YycFG) and ?(I) RsgI regulators cooperate to control CwlO and LytE expression in exponentially growing and stressed Bacillus subtilis cells. Mol Microbiol. 2013;87:180-95 pubmed publisher
    ..Thus the WalRK and ?(I) RsgI regulatory systems cooperate to control cell wall metabolism in growing and stressed cells...
  45. Diethmaier C, Newman J, Kovács Á, Kaever V, Herzberg C, Rodrigues C, et al. The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis. J Bacteriol. 2014;196:265-75 pubmed publisher
    ..subtilis. ..
  46. Oliva M, Trambaiolo D, L we J. Structural insights into the conformational variability of FtsZ. J Mol Biol. 2007;373:1229-42 pubmed publisher
    ..We propose a new model in which lateral interactions help determine the curvature of protofilaments...
  47. Torres C, Galián C, Freiberg C, Fantino J, Jault J. The YheI/YheH heterodimer from Bacillus subtilis is a multidrug ABC transporter. Biochim Biophys Acta. 2009;1788:615-22 pubmed publisher
    ..Therefore, B. subtilis YheI/YheH forms a new heterodimeric multidrug ABC transporter possibly involved in multiple antibiotic resistance in vivo...
  48. Reilman E, Mars R, van Dijl J, Denham E. The multidrug ABC transporter BmrC/BmrD of Bacillus subtilis is regulated via a ribosome-mediated transcriptional attenuation mechanism. Nucleic Acids Res. 2014;42:11393-407 pubmed publisher
    ..Altogether, we demonstrate for the first time that a ribosome-mediated transcriptional attenuation mechanism can control the expression of a multidrug ABC transporter. ..
  49. Bisicchia P, Noone D, Lioliou E, Howell A, Quigley S, Jensen T, et al. The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis. Mol Microbiol. 2007;65:180-200 pubmed
    ..A genetic analysis shows that YycFG essentiality is polygenic in nature, being a manifestation of disrupted cell wall metabolism caused by aberrant expression of a number of YycFG regulon genes. ..
  50. Bose B, Auchtung J, Lee C, Grossman A. A conserved anti-repressor controls horizontal gene transfer by proteolysis. Mol Microbiol. 2008;70:570-82 pubmed publisher
    ..subtilis phage phi105 is required for inactivation of the phi105 repressor (an ImmR homologue). ImmA-dependent proteolysis of ImmR repressors may be a conserved mechanism for regulating horizontal gene transfer...
  51. Even S, Burguière P, Auger S, Soutourina O, Danchin A, Martin Verstraete I. Global control of cysteine metabolism by CymR in Bacillus subtilis. J Bacteriol. 2006;188:2184-97 pubmed
    ..Transcriptome analysis of a delta cymR mutant and the wild-type strain also brought out significant changes in the expression level of a large set of genes related to stress response or to transition toward anaerobiosis. ..
  52. Belitsky B, Sonenshein A. Genetic and biochemical analysis of CodY-binding sites in Bacillus subtilis. J Bacteriol. 2008;190:1224-36 pubmed
    ..Our results show that versions of the AATTTTCWGAAAATT motif, first identified for Lactococcus lactis CodY, with up to five mismatches play an important role in the interaction of B. subtilis CodY with DNA. ..
  53. Formstone A, Carballido Lopez R, Noirot P, Errington J, Scheffers D. Localization and interactions of teichoic acid synthetic enzymes in Bacillus subtilis. J Bacteriol. 2008;190:1812-21 pubmed
    ..Taken together, our results suggest that, in B. subtilis at least, the synthesis and export of WTA precursors are mediated by a large multienzyme complex that may be associated with the PG-synthesizing machinery...
  54. Gyan S, Shiohira Y, Sato I, Takeuchi M, Sato T. Regulatory loop between redox sensing of the NADH/NAD(+) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis. J Bacteriol. 2006;188:7062-71 pubmed
    ..These results indicated that Rex and Ndh together form a regulatory loop which functions to prevent a large fluctuation in the NADH/NAD(+) ratio in B. subtilis. ..
  55. Matsuo Y, Morimoto T, Kuwano M, Loh P, Oshima T, Ogasawara N. The GTP-binding protein YlqF participates in the late step of 50 S ribosomal subunit assembly in Bacillus subtilis. J Biol Chem. 2006;281:8110-7 pubmed
    ..Our results collectively indicate that YlqF will organize the late step of 50 S ribosomal subunit assembly. ..
  56. Hayashi K, Kensuke T, Kobayashi K, Ogasawara N, Ogura M. Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode inhibitors of expression of the srfA operon. Mol Microbiol. 2006;59:1714-29 pubmed
    ..Thus, YvaN was renamed RghR (rapG and rapH repressor). As the rapH gene is activated by ComK and RapH inhibits comK indirectly, this constitutes an autoregulatory loop modulated by RghR. ..
  57. Claessen D, Emmins R, Hamoen L, Daniel R, Errington J, Edwards D. Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis. Mol Microbiol. 2008;68:1029-46 pubmed publisher
  58. Leaver M, Errington J. Roles for MreC and MreD proteins in helical growth of the cylindrical cell wall in Bacillus subtilis. Mol Microbiol. 2005;57:1196-209 pubmed
  59. Chu F, Kearns D, Branda S, Kolter R, Losick R. Targets of the master regulator of biofilm formation in Bacillus subtilis. Mol Microbiol. 2006;59:1216-28 pubmed
    ..These findings reinforce the view that SinR is a master regulator for biofilm formation and further suggest that a principal biological function of SinR is to govern the assembly of complex multicellular communities. ..
  60. Ishikawa S, Kawai Y, Hiramatsu K, Kuwano M, Ogasawara N. A new FtsZ-interacting protein, YlmF, complements the activity of FtsA during progression of cell division in Bacillus subtilis. Mol Microbiol. 2006;60:1364-80 pubmed
    ..These results suggest that YlmF has an overlapping function with FtsA in stimulating the formation of Z rings in B. subtilis. ..
  61. Ellermeier C, Losick R. Evidence for a novel protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in Bacillus subtilis. Genes Dev. 2006;20:1911-22 pubmed
    ..We identify residues important for proteolysis and a cluster of acidic residues involved in sensing antimicrobial peptides and cell envelope stress. ..
  62. Urbonavicius J, Brochier Armanet C, Skouloubris S, Myllykallio H, Grosjean H. In vitro detection of the enzymatic activity of folate-dependent tRNA (Uracil-54,-C5)-methyltransferase: evolutionary implications. Methods Enzymol. 2007;425:103-19 pubmed
    ..The phylogenetic analysis of TrmFO sequences suggests an ancient origin of this enzyme in bacteria. ..
  63. Kobayashi K. Gradual activation of the response regulator DegU controls serial expression of genes for flagellum formation and biofilm formation in Bacillus subtilis. Mol Microbiol. 2007;66:395-409 pubmed
    ..Taken together, we propose that a gradual increase in DegU and phospho-DegU levels induces a transition from growth as motile cells to growth as sessile, biofilm-forming cells. ..
  64. Moeller R, Setlow P, Horneck G, Berger T, Reitz G, Rettberg P, et al. Roles of the major, small, acid-soluble spore proteins and spore-specific and universal DNA repair mechanisms in resistance of Bacillus subtilis spores to ionizing radiation from X rays and high-energy charged-particle bombardment. J Bacteriol. 2008;190:1134-40 pubmed
  65. Reder A, Höper D, Weinberg C, Gerth U, Fraunholz M, Hecker M. The Spx paralogue MgsR (YqgZ) controls a subregulon within the general stress response of Bacillus subtilis. Mol Microbiol. 2008;69:1104-20 pubmed publisher
    ..Due to the strict sigma(B)-dependent expression of YqgZ it was renamed to MgsR (modulator of the general stress response). ..
  66. Varughese K, Tsigelny I, Zhao H. The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition state. J Bacteriol. 2006;188:4970-7 pubmed
    ..In order to visualize the autophosphorylation of the histidine kinase, KinA, and the subsequent phosphoryl transfer to Spo0F, we generated in silico models representing these reaction steps. ..
  67. Singh J, Makde R, Kumar V, Panda D. A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ. Biochemistry. 2007;46:11013-22 pubmed
    ..The results indicated an interesting possibility that the assembly dynamics of FtsZ in the Z-ring is regulated by the competition between positive and negative regulators sharing the same binding site on FtsZ. ..
  68. Sanchez H, Kidane D, Reed P, Curtis F, Cozar M, Graumann P, et al. The RuvAB branch migration translocase and RecU Holliday junction resolvase are required for double-stranded DNA break repair in Bacillus subtilis. Genetics. 2005;171:873-83 pubmed
    ..The results demonstrate that, as with E. coli RuvABC, RuvAB targets RecU to recombination intermediates and that all three proteins are required for repair of DSBs arising from lesions in chromosomal DNA. ..
  69. Schumacher M, Seidel G, Hillen W, Brennan R. Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. J Biol Chem. 2006;281:6793-800 pubmed
    ..This latter finding demonstrates that this contact region is necessary and sufficient to throw the allosteric switch to activate cre binding by CcpA. ..
  70. Hamoen L, Meile J, de Jong W, Noirot P, Errington J. SepF, a novel FtsZ-interacting protein required for a late step in cell division. Mol Microbiol. 2006;59:989-99 pubmed
    ..We conclude that SepF is a new member of the Gram positive divisome, required for proper execution of septum synthesis. ..
  71. Núñez Ramírez R, Velten M, Rivas G, Polard P, Carazo J, Donate L. Loading a ring: structure of the Bacillus subtilis DnaB protein, a co-loader of the replicative helicase. J Mol Biol. 2007;367:764-9 pubmed
    ..We propose a model whereby each DnaB monomer participates in both stacked components of the tetramer and displays a different overall shape. This asymmetric quaternary organization could be a general feature of ring loaders. ..
  72. Smits W, Hoa T, Hamoen L, Kuipers O, Dubnau D. Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein. Mol Microbiol. 2007;64:368-81 pubmed
    ..Although to our knowledge ComK is the only DNA binding protein shown to act in this novel fashion, other minor groove binding proteins may act similarly. ..
  73. Töwe S, Leelakriangsak M, Kobayashi K, Van Duy N, Hecker M, Zuber P, et al. The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis. Mol Microbiol. 2007;66:40-54 pubmed
    ..Moreover, the DeltaykvE mutant displayed a 2-MHQ and catechol resistant phenotype. YkvE was renamed as MhqR controlling a 2-MHQ and catechol-resistance regulon of B. subtilis. ..
  74. Wang E, Bauer M, Rogstam A, Linse S, Logan D, von Wachenfeldt C. Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex. Mol Microbiol. 2008;69:466-78 pubmed publisher
    ..A mechanism is proposed whereby conformational changes in a C-terminal domain-swapped helix mediate the transition from a flexible DNA binding form to a locked NADH-bound form incapable of binding DNA. ..
  75. Yasumura A, Abe S, Tanaka T. Involvement of nitrogen regulation in Bacillus subtilis degU expression. J Bacteriol. 2008;190:5162-71 pubmed publisher
    ..These results suggest that degU expression is controlled by the three promoters under different growth conditions. ..
  76. Uicker W, Schaefer L, Britton R. The essential GTPase RbgA (YlqF) is required for 50S ribosome assembly in Bacillus subtilis. Mol Microbiol. 2006;59:528-40 pubmed
    ..Based on these results we propose to rename the ylqF gene rbgA (ribosome biogenesis GTPase A). ..
  77. Franco I, Mota L, Soares C, de Sá Nogueira I. Functional domains of the Bacillus subtilis transcription factor AraR and identification of amino acids important for nucleoprotein complex assembly and effector binding. J Bacteriol. 2006;188:3024-36 pubmed
    ..This work presents a structural framework for the function of AraR and provides insight into the mechanistic mode of action of this modular repressor. ..
  78. Bobay B, Mueller G, Thompson R, Murzin A, Venters R, Strauch M, et al. NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins. J Biol Chem. 2006;281:21399-409 pubmed
    ..The results of accompanying in vitro DNA-binding studies serve to highlight binding differences between the two proteins. ..
  79. Fukushima T, Afkham A, Kurosawa S, Tanabe T, Yamamoto H, Sekiguchi J. A new D,L-endopeptidase gene product, YojL (renamed CwlS), plays a role in cell separation with LytE and LytF in Bacillus subtilis. J Bacteriol. 2006;188:5541-50 pubmed
    ..These specific localizations may be dependent on the LysM repeats in their N-terminal domains. The roles of CwlS, LytF, and LytE in cell separation are discussed. ..
  80. Heidrich N, Moll I, Brantl S. In vitro analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA. Nucleic Acids Res. 2007;35:4331-46 pubmed
    ..The intracellular concentrations of SR1 were calculated under different growth conditions. ..
  81. Commichau F, Herzberg C, Tripal P, Valerius O, Stülke J. A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: the glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltC. Mol Microbiol. 2007;65:642-54 pubmed
    ..This regulatory mechanism by the bifunctional enzyme RocG allows the tight control of glutamate metabolism by the availability of carbon and nitrogen sources. ..
  82. Loh P, Morimoto T, Matsuo Y, Oshima T, Ogasawara N. The GTP-binding protein YqeH participates in biogenesis of the 30S ribosome subunit in Bacillus subtilis. Genes Genet Syst. 2007;82:281-9 pubmed
    ..This finding raises the interesting possibility that YqeH participates in assembly of the 30S ribosomal subunit as well as other cellular functions essential for growth on solid media. ..
  83. Larsson J, Rogstam A, von Wachenfeldt C. YjbH is a novel negative effector of the disulphide stress regulator, Spx, in Bacillus subtilis. Mol Microbiol. 2007;66:669-84 pubmed
    ..YjbH is proposed to affect the cellular concentration of Spx by modulating proteolysis via the ClpXP protease. ..
  84. Ishikawa S, Ogura Y, Yoshimura M, Okumura H, Cho E, Kawai Y, et al. Distribution of stable DnaA-binding sites on the Bacillus subtilis genome detected using a modified ChIP-chip method. DNA Res. 2007;14:155-68 pubmed
  85. Nanamiya H, Kasai K, Nozawa A, Yun C, Narisawa T, Murakami K, et al. Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis. Mol Microbiol. 2008;67:291-304 pubmed
    ..The SAS proteins thus likely function in the biosynthesis of alarmone with a mode of action distinct from that of RelA-SpoT homologues. ..
  86. Schneider S, Zhang W, Soultanas P, Paoli M. Structure of the N-terminal oligomerization domain of DnaD reveals a unique tetramerization motif and provides insights into scaffold formation. J Mol Biol. 2008;376:1237-50 pubmed publisher
    ..Based upon our data, we propose a model for the DnaD-mediated scaffold formation. ..
  87. Lewin A, Crow A, Hodson C, Hederstedt L, Le Brun N. Effects of substitutions in the CXXC active-site motif of the extracytoplasmic thioredoxin ResA. Biochem J. 2008;414:81-91 pubmed publisher
    ..Finally, the in vivo functional properties of CEHC ResA are shown to be significantly affected compared with those of the wild-type protein. ..
  88. Inácio J, Correia I, de Sá Nogueira I. Two distinct arabinofuranosidases contribute to arabino-oligosaccharide degradation in Bacillus subtilis. Microbiology. 2008;154:2719-29 pubmed publisher
    ..subtilis. ..
  89. Yamamoto H, Miyake Y, Hisaoka M, Kurosawa S, Sekiguchi J. The major and minor wall teichoic acids prevent the sidewall localization of vegetative DL-endopeptidase LytF in Bacillus subtilis. Mol Microbiol. 2008;70:297-310 pubmed publisher
  90. You C, Lu H, Sekowska A, Fang G, Wang Y, Gilles A, et al. The two authentic methionine aminopeptidase genes are differentially expressed in Bacillus subtilis. BMC Microbiol. 2005;5:57 pubmed
    ..subtilis, respectively, when cells are grown under laboratory conditions. Their difference in activity on synthetic substrates suggests that they have different protein targets in vivo. ..
  91. Ioannou C, Schaeffer P, Dixon N, Soultanas P. Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis. Nucleic Acids Res. 2006;34:5247-58 pubmed
    ..DnaI is sufficient to load the replicative helicase from a complex with six DnaI molecules, so there is no requirement for a dual helicase loader system. ..
  92. Breier A, Grossman A. Whole-genome analysis of the chromosome partitioning and sporulation protein Spo0J (ParB) reveals spreading and origin-distal sites on the Bacillus subtilis chromosome. Mol Microbiol. 2007;64:703-18 pubmed
    ..Gene expression in areas near parS sites was similar in wild type and a spo0J null mutant, indicating that binding and spreading of Spo0J on DNA does not normally silence transcription of nearby genes. ..