Archaeoglobus fulgidus DSM 4304

Summary

Alias: Archaeoglobus fulgidus str. DSM 4304, Archaeoglobus fulgidus VC-16, Archaeoglobus fulgidus str. VC-16, Archaeoglobus fulgidus strain DSM 4304, Archaeoglobus fulgidus strain VC-16

Top Publications

  1. Min J, Landry J, Sternglanz R, Xu R. Crystal structure of a SIR2 homolog-NAD complex. Cell. 2001;105:269-79 pubmed
    ..The structures also provide important insights into the catalytic mechanism of NAD-dependent protein deacetylation by this family of enzymes. ..
  2. Chang J, Kim H, Hwang K, Lee J, Jackson S, Bell S, et al. Structural basis for the NAD-dependent deacetylase mechanism of Sir2. J Biol Chem. 2002;277:34489-98 pubmed
    ..The crystal structures of wild type and mutant derivatives of Sir2, in conjunction with biochemical analyses of the mutants, provide novel insights into the reaction mechanism of Sir2-mediated deacetylation. ..
  3. Avalos J, Boeke J, Wolberger C. Structural basis for the mechanism and regulation of Sir2 enzymes. Mol Cell. 2004;13:639-48 pubmed
    ..We propose a detailed structure-based mechanism for deacetylation and nicotinamide inhibition of Sir2 consistent with mutagenesis and enzymatic studies. ..
  4. Tran H, Allen M, Lowe J, Bycroft M. Structure of the Jab1/MPN domain and its implications for proteasome function. Biochemistry. 2003;42:11460-5 pubmed
    ..The structure reveals a fold that resembles that of cytidine deaminase and places the Jab1/MPN domain in a superfamily of metal dependent hydrolases. ..
  5. Smith J, Brachmann C, Celic I, Kenna M, Muhammad S, Starai V, et al. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A. 2000;97:6658-63 pubmed
  6. Avalos J, Celic I, Muhammad S, Cosgrove M, Boeke J, Wolberger C. Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol Cell. 2002;10:523-35 pubmed
    ..Based on the Sir2-Af2 substrate complex structure, mutations were made in the other A. fulgidus sirtuin, Sir2-Af1, that increased its affinity for the p53 peptide. ..
  7. Mandal A, Cheung W, ARGUELLO J. Characterization of a thermophilic P-type Ag+/Cu+-ATPase from the extremophile Archaeoglobus fulgidus. J Biol Chem. 2002;277:7201-8 pubmed
    ..Thus, it provides a model for structure-functional studies of these transporters. Moreover, its characterization will also contribute to an understanding of thermophilic ion transporters...
  8. Mana Capelli S, Mandal A, ARGUELLO J. Archaeoglobus fulgidus CopB is a thermophilic Cu2+-ATPase: functional role of its histidine-rich-N-terminal metal binding domain. J Biol Chem. 2003;278:40534-41 pubmed
    ..The His-NMBD appears to have a regulatory role affecting the metal transport rate by controlling the metal release/dephosphorylation rates...
  9. Mandal A, ARGUELLO J. Functional roles of metal binding domains of the Archaeoglobus fulgidus Cu(+)-ATPase CopA. Biochemistry. 2003;42:11040-7 pubmed
    ..Chem. 276, 2234-2242]. Therefore, the data suggest a regulatory mechanism in which the Cu-dependent N-MBD/ATP binding domain interaction would accelerate cation release, the enzyme rate-limiting step, and consequently Cu(+) transport...
  10. Parker J, Roe S, Barford D. Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J. 2004;23:4727-37 pubmed

Detail Information

Publications130 found, 100 shown here

  1. Min J, Landry J, Sternglanz R, Xu R. Crystal structure of a SIR2 homolog-NAD complex. Cell. 2001;105:269-79 pubmed
    ..The structures also provide important insights into the catalytic mechanism of NAD-dependent protein deacetylation by this family of enzymes. ..
  2. Chang J, Kim H, Hwang K, Lee J, Jackson S, Bell S, et al. Structural basis for the NAD-dependent deacetylase mechanism of Sir2. J Biol Chem. 2002;277:34489-98 pubmed
    ..The crystal structures of wild type and mutant derivatives of Sir2, in conjunction with biochemical analyses of the mutants, provide novel insights into the reaction mechanism of Sir2-mediated deacetylation. ..
  3. Avalos J, Boeke J, Wolberger C. Structural basis for the mechanism and regulation of Sir2 enzymes. Mol Cell. 2004;13:639-48 pubmed
    ..We propose a detailed structure-based mechanism for deacetylation and nicotinamide inhibition of Sir2 consistent with mutagenesis and enzymatic studies. ..
  4. Tran H, Allen M, Lowe J, Bycroft M. Structure of the Jab1/MPN domain and its implications for proteasome function. Biochemistry. 2003;42:11460-5 pubmed
    ..The structure reveals a fold that resembles that of cytidine deaminase and places the Jab1/MPN domain in a superfamily of metal dependent hydrolases. ..
  5. Smith J, Brachmann C, Celic I, Kenna M, Muhammad S, Starai V, et al. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A. 2000;97:6658-63 pubmed
  6. Avalos J, Celic I, Muhammad S, Cosgrove M, Boeke J, Wolberger C. Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol Cell. 2002;10:523-35 pubmed
    ..Based on the Sir2-Af2 substrate complex structure, mutations were made in the other A. fulgidus sirtuin, Sir2-Af1, that increased its affinity for the p53 peptide. ..
  7. Mandal A, Cheung W, ARGUELLO J. Characterization of a thermophilic P-type Ag+/Cu+-ATPase from the extremophile Archaeoglobus fulgidus. J Biol Chem. 2002;277:7201-8 pubmed
    ..Thus, it provides a model for structure-functional studies of these transporters. Moreover, its characterization will also contribute to an understanding of thermophilic ion transporters...
  8. Mana Capelli S, Mandal A, ARGUELLO J. Archaeoglobus fulgidus CopB is a thermophilic Cu2+-ATPase: functional role of its histidine-rich-N-terminal metal binding domain. J Biol Chem. 2003;278:40534-41 pubmed
    ..The His-NMBD appears to have a regulatory role affecting the metal transport rate by controlling the metal release/dephosphorylation rates...
  9. Mandal A, ARGUELLO J. Functional roles of metal binding domains of the Archaeoglobus fulgidus Cu(+)-ATPase CopA. Biochemistry. 2003;42:11040-7 pubmed
    ..Chem. 276, 2234-2242]. Therefore, the data suggest a regulatory mechanism in which the Cu-dependent N-MBD/ATP binding domain interaction would accelerate cation release, the enzyme rate-limiting step, and consequently Cu(+) transport...
  10. Parker J, Roe S, Barford D. Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J. 2004;23:4727-37 pubmed
  11. Avalos J, Bever K, Wolberger C. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell. 2005;17:855-68 pubmed publisher
    ..The characteristics of the altered specificity enzyme establish that Sir2 enzymes contain a single site that participates in catalysis and nicotinamide regulation and provides additional insights into the Sir2 catalytic mechanism...
  12. Büttner K, Wenig K, Hopfner K. Structural framework for the mechanism of archaeal exosomes in RNA processing. Mol Cell. 2005;20:461-71 pubmed
  13. Sazinsky M, Mandal A, ARGUELLO J, Rosenzweig A. Structure of the ATP binding domain from the Archaeoglobus fulgidus Cu+-ATPase. J Biol Chem. 2006;281:11161-6 pubmed
    ..Finally, the CopA ATPBD structure provides a basis for understanding the likely structural and functional effects of various mutations that lead to Wilson and Menkes diseases...
  14. Wang S, Kirillova O, Chruszcz M, Gront D, Zimmerman M, Cymborowski M, et al. The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of alpha + beta fold. Protein Sci. 2009;18:2410-9 pubmed publisher
    ..We hypothesize that AF2331 and AF2330 may form a charge-stabilized complex in vivo, though the role of the negatively charged surface clusters is not clear...
  15. Huang H, Levin E, Liu S, Bai Y, Lockless S, Zhou M. Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. PLoS Biol. 2014;12:e1001911 pubmed publisher
    ..Disease-causing mutations in UBIAD1 are clustered around the active site in AfUbiA, suggesting the mechanism of catalysis is conserved between the two homologs. ..
  16. Mamat B, Roth A, Grimm C, Ermler U, Tziatzios C, Schubert D, et al. Crystal structures and enzymatic properties of three formyltransferases from archaea: environmental adaptation and evolutionary relationship. Protein Sci. 2002;11:2168-78 pubmed publisher
    ..Conversely, the enzyme from M. barkeri and A. fulgidus already showed these properties, activity and stability, at much lower concentrations of these strong salting-out salts...
  17. Schmiedel R, Kuettner E, Keim A, Str ter N, Greiner St ffele T. Structure and function of the abasic site specificity pocket of an AP endonuclease from Archaeoglobus fulgidus. DNA Repair (Amst). 2009;8:219-31 pubmed publisher
    ..Moreover, with mutations of Phe 200 and Trp 215 we induced a strong exonucleolytic activity on undamaged DNA...
  18. Matsumoto S, Igura M, Nyirenda J, Matsumoto M, Yuzawa S, Noda N, et al. Crystal structure of the C-terminal globular domain of oligosaccharyltransferase from Archaeoglobus fulgidus at 1.75 Å resolution. Biochemistry. 2012;51:4157-66 pubmed publisher
    ..This classification provides a useful framework for OST studies...
  19. Murakami M, Shibuya K, Nakayama T, Nishino T, Yoshimura T, Hemmi H. Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus. FEBS J. 2007;274:805-14 pubmed publisher
    ..On the other hand, in the presence of NADPH (the preferred electron donor for plant homologues), the enzyme reaction did not proceed...
  20. T r I, Thore S, Mayer C, Basquin J, S raphin B, Suck D. RNA binding in an Sm core domain: X-ray structure and functional analysis of an archaeal Sm protein complex. EMBO J. 2001;20:2293-303 pubmed publisher
    ..A comparison with the structures of human Sm protein dimers reveals closely related monomer folds and intersubunit contacts, indicating that the architecture of the Sm core domain and RNA binding have been conserved during evolution...
  21. Arg ello J, Mandal A, Mana Capelli S. Heavy metal transport CPx-ATPases from the thermophile Archaeoglobus fulgidus. Ann N Y Acad Sci. 2003;986:212-8 pubmed
    ..These studies show that these enzymes are an excellent system for structural functional studies directed to explain the mechanisms of metal selectivity by PIB ATPases...
  22. Parizotto E, Lowe E, Parker J. Structural basis for duplex RNA recognition and cleavage by Archaeoglobus fulgidus C3PO. Nat Struct Mol Biol. 2013;20:380-6 pubmed publisher
    ..Trax-like-subunit catalytic sites target opposite strands of the duplex for cleavage separated by 7 base pairs. The structure provides insight into the mechanism of RNA recognition and cleavage by an archaeal C3PO-like complex. ..
  23. Zhang Y, Li H. Structure determination of a truncated dimeric splicing endonuclease in pseudo-face-centered space group P2(1)2(1)2. Acta Crystallogr D Biol Crystallogr. 2004;60:447-52 pubmed
    ..These results confirm the previously described structural features of dimeric splicing endonuclease. ..
  24. Levin I, Schwarzenbacher R, Page R, Abdubek P, Ambing E, Biorac T, et al. Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. Proteins. 2004;56:404-8 pubmed publisher
  25. Schiffer A, Fritz G, Kroneck P, Ermler U. Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states. Biochemistry. 2006;45:2960-7 pubmed publisher
    ..This structure documents how adjacent negative charges are stabilized by the protein matrix which is crucial for forming APS from AMP and sulfite in the reverse reaction...
  26. Yamagata A, Tainer J. Hexameric structures of the archaeal secretion ATPase GspE and implications for a universal secretion mechanism. EMBO J. 2007;26:878-90 pubmed publisher
  27. Powers R, Mirkovic N, Goldsmith Fischman S, Acton T, Chiang Y, Huang Y, et al. Solution structure of Archaeglobus fulgidis peptidyl-tRNA hydrolase (Pth2) provides evidence for an extensive conserved family of Pth2 enzymes in archea, bacteria, and eukaryotes. Protein Sci. 2005;14:2849-61 pubmed
  28. Smith N, Gallagher D. Structure and lability of archaeal dehydroquinase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:886-92 pubmed publisher
    ..Structural features that may contribute to stability, in particular ionic factors, are examined and the implications of having a T(m) below the organism's growth temperature are considered. ..
  29. Okabe M, Tomita K, Ishitani R, Ishii R, Takeuchi N, Arisaka F, et al. Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. EMBO J. 2003;22:5918-27 pubmed publisher
  30. Ai X, Li L, Semesi A, Yee A, Arrowsmith C, Li S, et al. Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold. J Biomol NMR. 2007;38:353-8 pubmed
    ..Our results suggest that although AF2241 adopts the same fold as the human cyclophilin A, it may have distinct biological function. ..
  31. Aittaleb M, Rashid R, Chen Q, Palmer J, Daniels C, Li H. Structure and function of archaeal box C/D sRNP core proteins. Nat Struct Biol. 2003;10:256-63 pubmed publisher
    ..A model of box C/D snoRNP assembly is proposed based on the presented structural and biochemical data...
  32. Moore T, Zhang Y, Fenley M, Li H. Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA. Structure. 2004;12:807-18 pubmed publisher
    ..These analyses provide a structural basis for interpreting the functional roles of the box C/D sequences in directing specific assembly of box C/D sRNPs...
  33. Stokke R, Karlstr m M, Yang N, Leiros I, Ladenstein R, Birkeland N, et al. Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers. Extremophiles. 2007;11:481-93 pubmed publisher
    ..Common and unique heat adaptive traits of AfIDH with those recently observed for hyperthermophilic IDH from Aeropyrum pernix (ApIDH) and Thermotoga maritima (TmIDH) are discussed herein...
  34. Upadhyay V, Demmer U, Warkentin E, Moll J, Shima S, Ermler U. Structure and catalytic mechanism of N(5),N(10)-methenyl-tetrahydromethanopterin cyclohydrolase. Biochemistry. 2012;51:8435-43 pubmed publisher
    ..For comparison, methenyltetrahydrofolate (H(4)F) cyclohydrolase produces N(10)-formyl-H(4)F in an analogous reaction. An enzymatic mechanism of Mch is postulated and compared with that of other cyclohydrolases. ..
  35. Allen M, Buckle A, Cordell S, L we J, Bycroft M. The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A. J Mol Biol. 2003;330:503-11 pubmed
    ..The structure also shows some similarity to members of the P-loop family of nucleotide hydrolases...
  36. Sandigursky M, Franklin W. Uracil-DNA glycosylase in the extreme thermophile Archaeoglobus fulgidus. J Biol Chem. 2000;275:19146-9 pubmed publisher
  37. Stec B, Yang H, Johnson K, Chen L, Roberts M. MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase. Nat Struct Biol. 2000;7:1046-50 pubmed publisher
    ..Moreover, several gene products annotated as IMPases from different thermophilic organisms also possess FBPase activity. Thus, we have found the FBPase that was 'missing' in thermophiles and shown that it also functions as an IMPase...
  38. Rodr guez A. Investigating the role of the latch in the positive supercoiling mechanism of reverse gyrase. Biochemistry. 2003;42:5993-6004 pubmed publisher
    ..The latch therefore plays an important role in the communication between the two domains of reverse gyrase...
  39. Sidote D, Hoffman D. NMR structure of an archaeal homologue of ribonuclease P protein Rpp29. Biochemistry. 2003;42:13541-50 pubmed publisher
  40. Sakasegawa S, Hagemeier C, Thauer R, Essen L, Shima S. Structural and functional analysis of the gpsA gene product of Archaeoglobus fulgidus: a glycerol-3-phosphate dehydrogenase with an unusual NADP+ preference. Protein Sci. 2004;13:3161-71 pubmed
  41. Knævelsrud I, Moen M, Grøsvik K, Haugland G, Birkeland N, Klungland A, et al. The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement. J Bacteriol. 2010;192:5755-66 pubmed publisher
    ..The finding that repair product formation is stimulated similarly by ATP and ADP in vitro raises the question of whether ADP is more important in vivo because of its higher heat stability. ..
  42. Jain S, Caforio A, Fodran P, Lolkema J, Minnaard A, Driessen A. Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea. Chem Biol. 2014;21:1392-1401 pubmed publisher
    ..Additionally, insights into archaeal lipid biosynthesis reported here allow addressing the evolutionary hypothesis of the lipid divide between Archaea and Bacteria. ..
  43. Giroux X, MacNeill S. A novel archaeal DNA repair factor that acts with the UvrABC system to repair mitomycin C-induced DNA damage in a PCNA-dependent manner. Mol Microbiol. 2016;99:1-14 pubmed publisher
    ..The wide distribution of NreA family members implies an important role for the protein in DNA damage repair in all archaeal lineages. ..
  44. Schr der I, Vadas A, Johnson E, Lim S, Monbouquette H. A novel archaeal alanine dehydrogenase homologous to ornithine cyclodeaminase and mu-crystallin. J Bacteriol. 2004;186:7680-9 pubmed publisher
    ..fulgidus AlaDH did not exhibit any ornithine cyclodeaminase activity. The recombinant human mu-crystallin was assayed for AlaDH activity, but no activity was detected. The novel A. fulgidus gene encoding AlaDH, AF1665, is designated ala...
  45. Leiros I, Nabong M, Gr svik K, Ringvoll J, Haugland G, Uldal L, et al. Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA. EMBO J. 2007;26:2206-17 pubmed publisher
    ..We present a high-resolution crystal structure of AfAlkA, which, together with the characterization of several site-directed mutants, forms a molecular rationalization for the newly discovered base excision activity...
  46. Zhu J, Fu Z, Chen L, Xu H, Chrzas J, Rose J, et al. Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal. Acta Crystallogr D Biol Crystallogr. 2012;68:1242-52 pubmed publisher
    ..The analysis also points out the advantage gained from carrying out data reduction and structure determination on-site while the crystal is still available for further data collection. ..
  47. Yamanaka Y, Zeppieri L, Nicolet Y, Marinoni E, de Oliveira J, Odaka M, et al. Crystal structure and functional studies of an unusual L-cysteine desulfurase from Archaeoglobus fulgidus. Dalton Trans. 2013;42:3092-9 pubmed publisher
    ..Here, we report that adding PLP to AfIscS produces an enzyme that displays in vitro L-cysteine desulfurase activity mediating the synthesis of a stable holo Af(IscU-D35A-IscS) complex. ..
  48. Meloni G, Zhang L, Rees D. Transmembrane type-2-like Cu2+ site in the P1B-3-type ATPase CopB: implications for metal selectivity. ACS Chem Biol. 2014;9:116-21 pubmed publisher
  49. Knævelsrud I, Kazazic S, Birkeland N, Bjelland S. The pH optimum of native uracil-DNA glycosylase of Archaeoglobus fulgidus compared to recombinant enzyme indicates adaption to cytosolic pH. Acta Biochim Pol. 2014;61:393-5 pubmed
    ..fulgidus optimal growth temperature of 83°C. Adaption to the neutral conditions in the A. fulgidus cytoplasm might be due to covalent modifications or accessory factors, or due to a different folding when expressed in the native host. ..
  50. Kuhn C, Wilusz J, Zheng Y, Beal P, Joshua Tor L. On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme. Cell. 2015;160:644-58 pubmed publisher
    ..Intriguingly, with the CCA-adding enzyme acting as a molecular vise, the RNAs proofread themselves through differential responses to its interrogation between stable and unstable substrates. ..
  51. Laronde Leblanc N, Guszczynski T, Copeland T, Wlodawer A. Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes. FEBS J. 2005;272:2800-10 pubmed publisher
    ..These results give us further information about the nature of the active site of Rio2 kinase and suggest a mechanism of regulation of its enzymatic activity...
  52. Brito J, Borges N, Santos H, Archer M. Production, crystallization and preliminary X-ray analysis of CTP:inositol-1-phosphate cytidylyltransferase from Archaeoglobus fulgidus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1463-5 pubmed publisher
    ..fulgidus in the apo form are reported. The crystals diffracted to 2.4?Å resolution using a synchrotron source and belonged to the orthorhombic space group P2(1)2(1)2, with unit-cell parameters a = 154.7, b = 83.9, c = 127.7?Å. ..
  53. Coulthurst S, Dawson A, Hunter W, Sargent F. Conserved signal peptide recognition systems across the prokaryotic domains. Biochemistry. 2012;51:1678-86 pubmed publisher
    ..This work suggests that archaea may employ a chaperone-dependent Tat proofreading system that is similar to that utilized by bacteria...
  54. Lehtiö L, Grossmann J, Kokona B, Fairman R, Goldman A. Crystal structure of a glycyl radical enzyme from Archaeoglobus fulgidus. J Mol Biol. 2006;357:221-35 pubmed
  55. Cordell S, L we J. Crystal structure of the bacterial cell division regulator MinD. FEBS Lett. 2001;492:160-5 pubmed
    ..Although MinD, unlike the proteins it interacts with and those it is structurally related to, is a monomer, not a dimer...
  56. Rodrigues J, Abreu I, Saraiva L, Teixeira M. Rubredoxin acts as an electron donor for neelaredoxin in Archaeoglobus fulgidus. Biochem Biophys Res Commun. 2005;329:1300-5 pubmed
    ..fulgidus (AF0880 and AF1349) and show that they act as efficient electron donors for neelaredoxin, in vitro, with a second-order rate constant of 10(7)M(-1)s(-1) at 10 degrees C and pH 7.2. ..
  57. Andrade S, Cruz F, Drennan C, Ramakrishnan V, Rees D, Ferry J, et al. Structures of the iron-sulfur flavoproteins from Methanosarcina thermophila and Archaeoglobus fulgidus. J Bacteriol. 2005;187:3848-54 pubmed publisher
    ..This is only possible between different monomers upon oligomerization. Fundamental differences in the surface properties of the two ISF homologs underscore the diversity encountered within this protein family...
  58. Liu J, Lou Y, Yokota H, Adams P, Kim R, Kim S. Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP. J Mol Biol. 2005;354:289-303 pubmed publisher
    ..A possible phosphate transfer mechanism is proposed on the basis of the structures presented...
  59. Tomita K, Ishitani R, Fukai S, Nureki O. Complete crystallographic analysis of the dynamics of CCA sequence addition. Nature. 2006;443:956-60 pubmed publisher
    ..Throughout the CCA-adding reaction, the enzyme tail domain firmly anchors the TPsiC-loop of the tRNA, which ensures accurate polymerization and termination...
  60. Lai D, Lluncor B, Schr der I, Gunsalus R, Liao J, Monbouquette H. Reconstruction of the archaeal isoprenoid ether lipid biosynthesis pathway in Escherichia coli through digeranylgeranylglyceryl phosphate. Metab Eng. 2009;11:184-91 pubmed publisher
  61. Nogly P, Gushchin I, Remeeva A, Esteves A, Borges N, Ma P, et al. X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism. Nat Commun. 2014;5:4169 pubmed publisher
    ..We show that magnesium is essential for the enzymatic activity and is involved in catalysis. Substrates docking is validated by mutagenesis studies, and a structure-based catalytic mechanism is proposed. ..
  62. Mander G, Duin E, Linder D, Stetter K, Hedderich R. Purification and characterization of a membrane-bound enzyme complex from the sulfate-reducing archaeon Archaeoglobus fulgidus related to heterodisulfide reductase from methanogenic archaea. Eur J Biochem. 2002;269:1895-904 pubmed
    ..Hence, Hdr and the A. fulgidus enzyme not only share sequence similarity, but may also have a similar active site and a similar catalytic function...
  63. Lehtiö L, Goldman A. The pyruvate formate lyase family: sequences, structures and activation. Protein Eng Des Sel. 2004;17:545-52 pubmed
    ..Surprisingly, most of the conserved residues in PFL-like enzymes appear to be involved in preserving the structure, rather than forming the active site. ..
  64. Pagala V, Park J, Reed D, Hartzell P. Cellular localization of D-lactate dehydrogenase and NADH oxidase from Archaeoglobus fulgidus. Archaea. 2002;1:95-104 pubmed
    ..Although these data show a tight interaction between NoxA2 and Dld, the role of NoxA2 in electron transport reactions is unknown. Rather, NoxA2 may protect proteins involved in electron transfer by reducing O2 to H2O2 or H2O. ..
  65. Yin J, Xu L, Cherney M, Raux Deery E, Bindley A, Savchenko A, et al. Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus. J Struct Funct Genomics. 2006;7:37-50 pubmed publisher
    ..In light of the hypothesis that suggests the larger chelatases evolved via gene duplication and fusion from a CbiX(S)-like enzyme, the structure of AF0721 may represent that of an "ancestral" precursor of class II metal chelatases...
  66. Fukunaga R, Yokoyama S. Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea. Nat Struct Mol Biol. 2007;14:272-9 pubmed publisher
    ..The mutant SepRS-tRNA pairs may be useful for translational incorporation of O-phosphoserine into proteins in response to the stop codons UGA and UAG...
  67. Marinoni E, de Oliveira J, Nicolet Y, Raulfs E, Amara P, Dean D, et al. (IscS-IscU)2 complex structures provide insights into Fe2S2 biogenesis and transfer. Angew Chem Int Ed Engl. 2012;51:5439-42 pubmed publisher
  68. Engstrom L, Partington O, David S. An iron-sulfur cluster loop motif in the Archaeoglobus fulgidus uracil-DNA glycosylase mediates efficient uracil recognition and removal. Biochemistry. 2012;51:5187-97 pubmed publisher
    ..This work underscores the requirement of an ensemble of interactions, both distant and in proximity to the damaged site, for accurate and efficient uracil excision. ..
  69. Andrade S, Dickmanns A, Ficner R, Einsle O. Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus. Proc Natl Acad Sci U S A. 2005;102:14994-9 pubmed publisher
    ..In this model, GlnB-1 binds tightly to the cytoplasmic face of the transporter, effectively blocking conduction through the three individual substrate channels...
  70. Sciara G, Clarke O, Tomasek D, Kloss B, Tabuso S, Byfield R, et al. Structural basis for catalysis in a CDP-alcohol phosphotransferase. Nat Commun. 2014;5:4068 pubmed publisher
  71. Johnson K, Chen L, Yang H, Roberts M, Stec B. Crystal structure and catalytic mechanism of the MJ0109 gene product: a bifunctional enzyme with inositol monophosphatase and fructose 1,6-bisphosphatase activities. Biochemistry. 2001;40:618-30 pubmed
  72. Chapados B, Chai Q, Hosfield D, Qiu J, Shen B, Tainer J. Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication. J Mol Biol. 2001;307:541-56 pubmed publisher
  73. Fritz G, Roth A, Schiffer A, B chert T, Bourenkov G, Bartunik H, et al. Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-A resolution. Proc Natl Acad Sci U S A. 2002;99:1836-41 pubmed publisher
    ..The exceptionally large difference in reduction potential of these clusters (-60 and -500 mV) can be explained by interactions of the clusters with the protein matrix...
  74. De Simone G, Menchise V, Manco G, Mandrich L, Sorrentino N, Lang D, et al. The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus. J Mol Biol. 2001;314:507-18 pubmed publisher
    ..The variety of structural differences suggests possible strategies for thermostabilization of lipases and esterases with potential industrial applications...
  75. Seybert A, Scott D, Scaife S, Singleton M, Wigley D. Biochemical characterisation of the clamp/clamp loader proteins from the euryarchaeon Archaeoglobus fulgidus. Nucleic Acids Res. 2002;30:4329-38 pubmed
    ..However, both the large and small afRFC subunits showed interaction with afPCNA. Furthermore, we demonstrate that ATP binding, but not hydrolysis, is needed to stimulate interactions of the afRFC complex with afPCNA and DNA...
  76. Schiefner A, Holtmann G, Diederichs K, Welte W, Bremer E. Structural basis for the binding of compatible solutes by ProX from the hyperthermophilic archaeon Archaeoglobus fulgidus. J Biol Chem. 2004;279:48270-81 pubmed publisher
    ..The residues involved in ligand binding are functionally equivalent but not conserved in the primary sequence...
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    ..Implications for the mechanism by which histone acetylation modulates gene expression are discussed...