Plasmodium falciparum 3D7


Alias: Plasmodium falciparum (isolate 3D7), PLASMODIUM FALCIPARUM (ISOLATE 3D7).

Top Publications

  1. Khan S, Sharma A, Jamwal A, Sharma V, Pole A, Thakur K, et al. Uneven spread of cis- and trans-editing aminoacyl-tRNA synthetase domains within translational compartments of P. falciparum. Sci Rep. 2011;1:188 pubmed publisher
    ..Further development of such inhibitors may lead to anti-parasitics which simultaneously block protein translation in two key parasite organelles, a strategy of wider applicability for pathogen control. ..
  2. Siddiqui F, Dhawan S, Singh S, Singh B, Gupta P, Pandey A, et al. A thrombospondin structural repeat containing rhoptry protein from Plasmodium falciparum mediates erythrocyte invasion. Cell Microbiol. 2013;15:1341-56 pubmed publisher
    ..These observations suggest that targeting multiple conserved parasite ligands involved in different steps of invasion may provide an effective strategy for the development of vaccines against blood stage malaria parasites. ..
  3. Volz J, Bartfai R, Petter M, Langer C, Josling G, Tsuboi T, et al. PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division. Cell Host Microbe. 2012;11:7-18 pubmed publisher
    ..PfSET10 likely maintains the transcriptionally permissive chromatin environment of the active var promoter and thus retains memory for heritable transmission of epigenetic information during parasite division. ..
  4. Hoeijmakers W, Flueck C, Francoijs K, Smits A, Wetzel J, Volz J, et al. Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony. Cell Microbiol. 2012;14:1391-401 pubmed publisher
    ..These findings suggest that DNA-associated and epigenetic elements play an important role in centromere establishment in this important human pathogen. ..
  5. Choveaux D, Przyborski J, Goldring J. A Plasmodium falciparum copper-binding membrane protein with copper transport motifs. Malar J. 2012;11:397 pubmed publisher
    ..Localization of the protein to the erythrocyte and parasite plasma membranes could provide a mechanism for the delivery of novel anti-malarial compounds. ..
  6. Matthews K, Kalanon M, Chisholm S, Sturm A, Goodman C, Dixon M, et al. The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth. Mol Microbiol. 2013;89:1167-86 pubmed publisher
    ..Thus, while not essential for parasite survival, TRX2 may help to optimize PTEX activity. Importantly, the generation of TRX2 knockout parasites that display altered phenotypes provides a much-needed tool to dissect PTEX function. ..
  7. Haussig J, Matuschewski K, Kooij T. Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites. Mol Microbiol. 2011;81:1511-25 pubmed publisher
  8. Meister S, Plouffe D, Kuhen K, Bonamy G, Wu T, Barnes S, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011;334:1372-7 pubmed publisher
    ..The open-source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms...
  9. Koukouikila Koussounda F, Malonga V, Mayengue P, Ndounga M, Vouvoungui C, Ntoumi F. Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections. Malar J. 2012;11:105 pubmed publisher
    ..The low prevalence of asymptomatic infections and MOI is discussed in the light of similar studies conducted in Central Africa. ..

More Information

Publications255 found, 100 shown here

  1. Guttery D, Ferguson D, Poulin B, Xu Z, Straschil U, Klop O, et al. A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathog. 2012;8:e1002554 pubmed publisher
    ..This suggests that CDC20 and MAP2 are both likely to play independent but vital roles in male gametogenesis. ..
  2. Ahmad M, Ansari A, Tarique M, Satsangi A, Tuteja R. Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction. PLoS ONE. 2012;7:e49385 pubmed publisher
    ..These studies will make an important contribution in understanding the nucleic acid transaction in the malaria parasite. ..
  3. Gisselberg J, Dellibovi Ragheb T, Matthews K, Bosch G, Prigge S. The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites. PLoS Pathog. 2013;9:e1003655 pubmed publisher
    ..Taken together, these results demonstrate that the Suf pathway is essential for parasite survival and has a fundamental role in maintaining the apicoplast organelle in addition to any role in isoprenoid biosynthesis. ..
  4. Maier A, Rug M, O Neill M, Brown M, Chakravorty S, Szestak T, et al. Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell. 2008;134:48-61 pubmed publisher
    ..Collectively these proteins function as a pathogen secretion system, similar to bacteria and may provide targets for antivirulence based therapies to a disease responsible for millions of deaths annually. ..
  5. Khaminsou N, Kritpetcharat O, Daduang J, Charerntanyarak L, Kritpetcharat P. Genetic analysis of the merozoite surface protein-1 block 2 allelic types in Plasmodium falciparum clinical isolates from Lao PDR. Malar J. 2011;10:371 pubmed publisher
    ..A rather high level of multiple clonal infections was also observed but the multiplicity of infection was rather low as not exceed 2.0. This basic data are useful for treatment and malaria control program in Lao PDR. ..
  6. Akinyi S, Hayden T, Gamboa D, Torres K, Bendezu J, Abdallah J, et al. Multiple genetic origins of histidine-rich protein 2 gene deletion in Plasmodium falciparum parasites from Peru. Sci Rep. 2013;3:2797 pubmed publisher
    ..These findings indicate that the genetic origin of pfhrp2 deletion in Peru was not a single event, but likely occurred multiple times. ..
  7. Lau T, Sylvi M, William T. Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia. Malar J. 2013;12:445 pubmed publisher
    ..High prevalence of mutations in SDX/PYR associated drug resistance genes are reported in this study. This mutational study of pfdhps and pfdhfr indicating that SDX/PYR should be discontinued in this region. ..
  8. Silvie O, Goetz K, Matuschewski K. A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development. PLoS Pathog. 2008;4:e1000086 pubmed publisher
    ..These findings have important implications for the development of genetically attenuated parasites as a vaccine approach. ..
  9. Odom A, Van Voorhis W. Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. Mol Biochem Parasitol. 2010;170:108-11 pubmed publisher
    ..These data indicate that DXR is required for intraerythrocytic development of P. falciparum. ..
  10. Spalding M, Allary M, Gallagher J, Prigge S. Validation of a modified method for Bxb1 mycobacteriophage integrase-mediated recombination in Plasmodium falciparum by localization of the H-protein of the glycine cleavage complex to the mitochondrion. Mol Biochem Parasitol. 2010;172:156-60 pubmed publisher
    ..Here, we demonstrate that this modification results in rapid generation of chromosomally integrated transgenic parasites, and we show that the H-protein localizes to the mitochondrion. ..
  11. Dvorin J, Martyn D, Patel S, Grimley J, Collins C, Hopp C, et al. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science. 2010;328:910-2 pubmed publisher
    ..The arrest was downstream of cyclic guanosine monophosphate-dependent protein kinase (PfPKG) function and independent of protease processing. Thus, PfCDPK5 plays an essential role during the blood stage of malaria replication. ..
  12. Bin Dajem S, Al Qahtani A. Analysis of gene mutations involved in chloroquine resistance in Plasmodium falciparum parasites isolated from patients in the southwest of Saudi Arabia. Ann Saudi Med. 2010;30:187-92 pubmed publisher
    ..This study will contribute to the development of new strategies for therapeutic intervention against malaria in Saudi Arabia. ..
  13. Kafsack B, Rovira Graells N, Clark T, Bancells C, Crowley V, Campino S, et al. A transcriptional switch underlies commitment to sexual development in malaria parasites. Nature. 2014;507:248-52 pubmed publisher
    ..Overall, these findings identify PfAP2-G as a master regulator of sexual-stage development in malaria parasites and mark the first discovery of a transcriptional switch controlling a differentiation decision in protozoan parasites. ..
  14. Halbert J, Ayong L, Equinet L, Le Roch K, Hardy M, Goldring D, et al. A Plasmodium falciparum transcriptional cyclin-dependent kinase-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity. Eukaryot Cell. 2010;9:952-9 pubmed publisher
    ..Taken together, our data strongly suggest that Pfcrk-3 fulfils a crucial role in the intraerythrocytic development of P. falciparum, presumably through chromatin modification-dependent regulation of gene expression. ..
  15. Leykauf K, Treeck M, Gilson P, Nebl T, Braulke T, Cowman A, et al. Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite. PLoS Pathog. 2010;6:e1000941 pubmed publisher
    ..In addition to shedding unexpected new light on AMA1 function, this work represents the first time PKA has been implicated in merozoite invasion. ..
  16. Guttery D, Poulin B, Ferguson D, Szoor B, Wickstead B, Carroll P, et al. A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathog. 2012;8:e1002948 pubmed publisher
    ..Our work demonstrates a stage-specific essentiality of the unique PPKL enzyme, which modulates parasite differentiation, motility and transmission. ..
  17. Martin R, Marchetti R, Cowan A, Howitt S, Broer S, Kirk K. Chloroquine transport via the malaria parasite's chloroquine resistance transporter. Science. 2009;325:1680-2 pubmed publisher
    ..CQ transport via the mutant PfCRT was inhibited by CQ analogs and by the resistance-reverser verapamil. Thus, CQ resistance is due to direct transport of the drug via mutant PfCRT. ..
  18. Hossain M, Dhawan S, Mohmmed A. The cysteine-rich regions of Plasmodium falciparum RON2 bind with host erythrocyte and AMA1 during merozoite invasion. Parasitol Res. 2012;110:1711-21 pubmed publisher
    ..These results suggest that PfRON2 plays a role in merozoite invasion and thus it can be an important vaccine candidate antigen. ..
  19. Veiga M, Ferreira P, Jörnhagen L, Malmberg M, Kone A, Schmidt B, et al. Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance. PLoS ONE. 2011;6:e20212 pubmed publisher
    ..Our work unveils new candidate markers of P. falciparum multidrug resistance in vitro, while contributing to the understanding of subjacent genetic complexity, essential for future evidence-based drug policy decisions. ..
  20. Patzewitz E, Guttery D, Poulin B, Ramakrishnan C, Ferguson D, Wall R, et al. An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission. Cell Rep. 2013;3:622-9 pubmed publisher
    ..This study emphasizes the varied functions of SHLP1 in Plasmodium ookinete biology and suggests that it could be a novel drug target for blocking parasite transmission. ..
  21. Malpede B, Lin D, Tolia N. Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL. J Biol Chem. 2013;288:12406-15 pubmed publisher
    ..falciparum erythrocyte invasion interface and define a framework for development of PfEBA-140-based therapeutics, vaccines, and diagnostics assessing vaccine efficacy and natural immunity to infection...
  22. Agop Nersesian C, Naissant B, Ben Rached F, Rauch M, Kretzschmar A, Thiberge S, et al. Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis. PLoS Pathog. 2009;5:e1000270 pubmed publisher
    ..We propose a model where Rab11A-mediated vesicular traffic driven by an MTIP-Myosin motor is necessary for IMC maturation and to deliver new plasma membrane to daughter cells in order to complete cell division...
  23. Clausen T, Christoffersen S, Dahlbäck M, Langkilde A, Jensen K, Resende M, et al. Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria. J Biol Chem. 2012;287:23332-45 pubmed publisher
    ..Based on these novel PfEMP1 structure-function studies, we have constructed a small VAR2CSA antigen that has the capacity to induce highly adhesion-blocking antibodies. ..
  24. Maenpuen S, Sopitthummakhun K, Yuthavong Y, Chaiyen P, Leartsakulpanich U. Characterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial target. Mol Biochem Parasitol. 2009;168:63-73 pubmed publisher
    ..Kinetic data in combination with expression result support the proposal of SHMT reaction being a regulatory step for dTMP cycle. This finding suggests that PfSHMT can be a potential target for antimalarial chemotherapy. ..
  25. Comeaux C, Coleman B, Bei A, Whitehurst N, Duraisingh M. Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth. Mol Microbiol. 2011;80:378-90 pubmed publisher
    ..Epigenetic regulation of these chromosomally proximal members of a multigene family provides a mechanism for both immune evasion and functional diversification. ..
  26. Spillman N, Allen R, McNamara C, Yeung B, Winzeler E, Diagana T, et al. Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe. 2013;13:227-37 pubmed publisher
    ..The mutant parasites also show some impairment of Na(+) regulation. Taken together, our results are consistent with PfATP4 being a Na(+) efflux ATPase and a target of the spiroindolones...
  27. Parish L, Mai D, Jones M, Kitson E, Rayner J. A member of the Plasmodium falciparum PHIST family binds to the erythrocyte cytoskeleton component band 4.1. Malar J. 2013;12:160 pubmed publisher
    ..1R interacts with the P. falciparum protein mature parasite-infected erythrocyte surface antigen (MESA), but it is not currently known whether other P. falciparum proteins bind to other lobes of the 4.1R N-terminal domain...
  28. Singh S, Soe S, Weisman S, Barnwell J, Pérignon J, Druilhe P. A conserved multi-gene family induces cross-reactive antibodies effective in defense against Plasmodium falciparum. PLoS ONE. 2009;4:e5410 pubmed publisher
  29. Bullen H, Tonkin C, O Donnell R, Tham W, Papenfuss A, Gould S, et al. A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role. J Biol Chem. 2009;284:25353-63 pubmed publisher
    ..Hence, these proteins are strong candidates for an IMC-anchoring role, either directly or indirectly tethering the motor to the cytoskeleton. ..
  30. Flueck C, Bartfai R, Volz J, Niederwieser I, Salcedo Amaya A, Alako B, et al. Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog. 2009;5:e1000569 pubmed publisher
    ..In summary, we identify PfHP1 as a major effector of virulence gene silencing and phenotypic variation. Our results are instrumental for our understanding of this widely used survival strategy in unicellular pathogens. ..
  31. Bartholdson S, Bustamante L, Crosnier C, Johnson S, Lea S, Rayner J, et al. Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP. PLoS Pathog. 2012;8:e1003031 pubmed publisher
    ..These findings now provide important experimental evidence to support the model that parasite TRAP-family ligands interact with specific host receptors during cellular invasion...
  32. Agrawal S, Chung D, Ponts N, van Dooren G, Prudhomme J, Brooks C, et al. An apicoplast localized ubiquitylation system is required for the import of nuclear-encoded plastid proteins. PLoS Pathog. 2013;9:e1003426 pubmed publisher
    ..Our studies suggest ubiquitylation to be a mechanistic requirement of apicoplast protein import independent to the proteasomal degradation pathway. ..
  33. Pesce E, Acharya P, Tatu U, Nicoll W, Shonhai A, Hoppe H, et al. The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns. Int J Biochem Cell Biol. 2008;40:2914-26 pubmed publisher
    ..Our results suggest a possible involvement of Pfj4 together with PfHsp70-1 in cytoprotection, and therefore, parasite survival inside the erythrocyte. ..
  34. Wilkes J, Doerig C. The protein-phosphatome of the human malaria parasite Plasmodium falciparum. BMC Genomics. 2008;9:412 pubmed publisher
  35. Baum J, Chen L, Healer J, Lopaticki S, Boyle M, Triglia T, et al. Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum. Int J Parasitol. 2009;39:371-80 pubmed publisher
    ..Given its small size, we believe PfRh5 may prove to be a valuable candidate for inclusion in a multi-component anti-malarial vaccine. ..
  36. Russo I, Oksman A, Goldberg D. Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus. Mol Microbiol. 2009;72:229-45 pubmed publisher
    ..falciparum calpain localization. The targeting signals function in mammalian cells as well as in the parasite. P. falciparum calpain is a unique nucleolar protein with an interesting mechanism of targeting. ..
  37. Pérez Toledo K, Rojas Meza A, Mancio Silva L, Hernández Cuevas N, Delgadillo D, Vargas M, et al. Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes. Nucleic Acids Res. 2009;37:2596-606 pubmed publisher
    ..This is the first report implicating an HP1 protein in the control of antigenic variation of a protozoan parasite. ..
  38. Treeck M, Zacherl S, Herrmann S, Cabrera A, Kono M, Struck N, et al. Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process. PLoS Pathog. 2009;5:e1000322 pubmed publisher
    ..We show that the cytoplasmic domain of AMA-1 is phosphorylated. Mutational analysis suggests an important role for the phosphorylation in the invasion process, which might translate into novel therapeutic strategies. ..
  39. Chitale M, Hawkins T, Park C, Kihara D. ESG: extended similarity group method for automated protein function prediction. Bioinformatics. 2009;25:1739-45 pubmed publisher
    ..ESG web server is available for automated protein function prediction at ..
  40. Bhatt T, Kapil C, Khan S, Jairajpuri M, Sharma V, Santoni D, et al. A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum. BMC Genomics. 2009;10:644 pubmed publisher
    ..The sets of distinct features elaborated in this work will provide a platform for experimental dissection of this family of enzymes, possibly for the discovery of novel drugs against malaria. ..
  41. Regev Rudzki N, Wilson D, Carvalho T, Sisquella X, Coleman B, Rug M, et al. Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles. Cell. 2013;153:1120-33 pubmed publisher
    ..falciparum biology critical for survival in the host and transmission to mosquitoes. This identifies a pathway for the development of agents to block parasite transmission from the human host to the mosquito. ..
  42. Klein M, Gittis A, Su H, Makobongo M, Moore J, Singh S, et al. The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure. PLoS Pathog. 2008;4:e1000147 pubmed publisher
    ..This new understanding of PfEMP1 structure will allow the use of better-defined PfEMP1 domains for functional studies, for the design of candidate vaccines, and for understanding the molecular basis of cytoadherence. ..
  43. Toure Balde A, Perlaza B, Sauzet J, Ndiaye M, Aribot G, Tall A, et al. Evidence for multiple B- and T-cell epitopes in Plasmodium falciparum liver-stage antigen 3. Infect Immun. 2009;77:1189-96 pubmed publisher
  44. Juillerat A, Lewit Bentley A, Guillotte M, Gangnard S, Hessel A, Baron B, et al. Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition. Proc Natl Acad Sci U S A. 2011;108:5243-8 pubmed publisher
    ..The specific interaction observed with heparin opens the way for developing antirosetting therapeutic strategies. ..
  45. Talman A, Lacroix C, Marques S, Blagborough A, Carzaniga R, Menard R, et al. PbGEST mediates malaria transmission to both mosquito and vertebrate host. Mol Microbiol. 2011;82:462-74 pubmed publisher
    ..These findings indicate that a single malaria protein may have pleiotropic roles in different parasites stages mediating transmission between its insect and mammalian hosts...
  46. Kitamura K, Kishi Itakura C, Tsuboi T, Sato S, Kita K, Ohta N, et al. Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum. PLoS ONE. 2012;7:e42977 pubmed publisher
    ..These data suggest that, although Plasmodium parasites have lost most Atg proteins during evolution, they use the Atg8 conjugation system for the unique organelle, the apicoplast. ..
  47. Zeeshan M, Alam M, Vinayak S, Bora H, Tyagi R, Alam M, et al. Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine. PLoS ONE. 2012;7:e43430 pubmed publisher
    ..In conclusion, this study provides an insight on the existing polymorphisms in the CSP in a parasite population from India that could potentially influence the efficacy of RTS,S vaccine in this region. ..
  48. Kimura R, Komaki Yasuda K, Kawazu S, Kano S. 2-Cys peroxiredoxin of Plasmodium falciparum is involved in resistance to heat stress of the parasite. Parasitol Int. 2013;62:137-43 pubmed publisher
    ..The hyperthermal protective function of the PfTPx-1 is obviously important for the parasite physiology in the human patient body, in which it must survive repeated incidences of fever...
  49. Bargieri D, Andenmatten N, Lagal V, Thiberge S, Whitelaw J, Tardieux I, et al. Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion. Nat Commun. 2013;4:2552 pubmed publisher
    ..These genetic data have implications on the use of apical membrane antigen 1 or the apical membrane antigen 1-rhoptry neck 2 interaction as targets of intervention strategies against malaria or other diseases caused by apicomplexans. ..
  50. Sanchez C, Rotmann A, Stein W, Lanzer M. Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum. Mol Microbiol. 2008;70:786-98 pubmed publisher
    ..falciparum digestive vacuole, and that this contributes to accumulation of, and susceptibility to, the drug in question...
  51. Saliba K, Lehane A, Kirk K. A polymorphic drug pump in the malaria parasite. Mol Microbiol. 2008;70:775-9 pubmed publisher
    ..The work provides important new insights into the mechanism by which Pgh1 influences malaria parasite drug sensitivity...
  52. Proellocks N, Kats L, Sheffield D, Hanssen E, Black C, Waller K, et al. Characterisation of PfRON6, a Plasmodium falciparum rhoptry neck protein with a novel cysteine-rich domain. Int J Parasitol. 2009;39:683-92 pubmed publisher
    ..Further, the cysteine-rich domain appears to be functionally important as it cannot be truncated. Taken together, these data identify PfRON6 as a novel and potentially important component of the Plasmodium invasion machinery. ..
  53. Ponzi M, Sidén Kiamos I, Bertuccini L, Currà C, Kroeze H, Camarda G, et al. Egress of Plasmodium berghei gametes from their host erythrocyte is mediated by the MDV-1/PEG3 protein. Cell Microbiol. 2009;11:1272-88 pubmed publisher
    ..These data demonstrate that emergence from the host cell of male and female gametes relies on a common, MDV-1/PEG3-dependent mechanism that is distinct from mechanisms used by asexual parasites. ..
  54. Deng X, Gujjar R, El Mazouni F, Kaminsky W, Malmquist N, Goldsmith E, et al. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J Biol Chem. 2009;284:26999-7009 pubmed publisher
    ..Together, these studies will directly impact efforts to exploit PfDHODH for the development of anti-malarial chemotherapy. ..
  55. Bhatt T, Yogavel M, Wydau S, Berwal R, Sharma A. Ligand-bound structures provide atomic snapshots for the catalytic mechanism of D-amino acid deacylase. J Biol Chem. 2010;285:5917-30 pubmed publisher
    ..Our studies provide a comprehensive structural basis for the catalytic mechanism of DTD enzymes and have implications for inhibition of this enzyme in P. falciparum as a route to inhibiting the parasite. ..
  56. Pachlatko E, Rusch S, Müller A, Hemphill A, Tilley L, Hanssen E, et al. MAHRP2, an exported protein of Plasmodium falciparum, is an essential component of Maurer's cleft tethers. Mol Microbiol. 2010;77:1136-52 pubmed publisher
    ..Solubilization studies showed that MAHRP2 is membrane associated but not membrane spanning. Several attempts to delete the mahrp2 gene failed, indicating that the protein is essential for parasite survival. ..
  57. Kusi K, Faber B, Riasat V, Thomas A, Kocken C, Remarque E. Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response. PLoS ONE. 2010;5:e15391 pubmed publisher
    ..Our data confirms the feasibility and potential of multi-allele PfAMA1 formulations, and highlights the need for adjuvants with improved antibody potentiation properties for AMA1-based vaccines. ..
  58. Aminake M, Schoof S, Sologub L, Leubner M, Kirschner M, Arndt H, et al. Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast. Antimicrob Agents Chemother. 2011;55:1338-48 pubmed publisher
  59. Dastidar E, Dayer G, Holland Z, Dorin Semblat D, Claes A, Chêne A, et al. Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway. BMC Biol. 2012;10:5 pubmed publisher
    ..This study paves the way for a kinome-wide interactomics-based approach to elucidate protein kinase function in malaria parasites. ..
  60. Philip N, Vaikkinen H, Tetley L, Waters A. A unique Kelch domain phosphatase in Plasmodium regulates ookinete morphology, motility and invasion. PLoS ONE. 2012;7:e44617 pubmed publisher
  61. Singh P, Kanodia S, Dandin C, Vijayraghavan U, Malhotra P. Plasmodium falciparum Prp16 homologue and its role in splicing. Biochim Biophys Acta. 2012;1819:1186-99 pubmed publisher
    ..These results suggest that although the role of Prp16p in catalytic step II is highly conserved among Plasmodium, human and yeast, subtle differences exist with regards to its associated factors or its assembly with spliceosomes. ..
  62. Glaser S, van Dooren G, Agrawal S, Brooks C, McFadden G, Striepen B, et al. Tic22 is an essential chaperone required for protein import into the apicoplast. J Biol Chem. 2012;287:39505-12 pubmed publisher
    ..Such a chaperone had not been identified in the intermembrane space of plastids and we propose that Tic22 fulfills this role. ..
  63. Zhang Q, Siegel T, Martins R, Wang F, Cao J, Gao Q, et al. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature. 2014;513:431-5 pubmed publisher
    ..Additionally, the identification of RNase II as a parasite protein controlling the expression of virulence genes involved in pathogenesis in patients with severe malaria may provide new strategies for reducing malaria mortality. ..
  64. Pleeter P, Lekostaj J, Roepe P. Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue. Mol Biochem Parasitol. 2010;173:158-61 pubmed publisher
    ..falciparum multi-drug resistance transporter, and that there is an isoform specific competition between the two transporters for binding of quinoline antimalarial drugs. ..
  65. Agarwal S, Kern S, Halbert J, Przyborski J, Baumeister S, Dandekar T, et al. Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor. J Cell Biochem. 2011;112:1295-310 pubmed publisher
    ..Our data indicate a crucial role of PfCLKs for malaria blood stage parasites, presumably by participating in gene regulation through the post-transcriptional modification of mRNA. ..
  66. Külzer S, Charnaud S, Dagan T, Riedel J, Mandal P, Pesce E, et al. Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte. Cell Microbiol. 2012;14:1784-95 pubmed publisher
    ..The host-pathogen interaction within the infected erythrocyte is more complex than previously thought, and is driven notonly by parasite co-chaperones, but also by the parasite-encoded chaperone Hsp70-x itself. ..
  67. Fréville A, Cailliau Maggio K, Pierrot C, Tellier G, Kalamou H, Lafitte S, et al. Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy. BMC Biol. 2013;11:80 pubmed publisher
  68. Heiber A, Kruse F, Pick C, Grüring C, Flemming S, Oberli A, et al. Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export. PLoS Pathog. 2013;9:e1003546 pubmed publisher
  69. Oppenheim R, Creek D, Macrae J, Modrzynska K, Pino P, Limenitakis J, et al. BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathog. 2014;10:e1004263 pubmed publisher
    ..Overall this study highlights the importance of the molecular adaptation of BCKDH in this important class of pathogens. ..
  70. Ram E, Naik R, Ganguli M, Habib S. DNA organization by the apicoplast-targeted bacterial histone-like protein of Plasmodium falciparum. Nucleic Acids Res. 2008;36:5061-73 pubmed publisher
    ..Our results provide the first functional characterization of an apicomplexan HU protein and provide additional evidence for red algal ancestry of the apicoplast. ..
  71. Nkrumah L, Riegelhaupt P, Moura P, Johnson D, Patel J, Hayton K, et al. Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol Biochem Parasitol. 2009;165:122-31 pubmed publisher
    ..These data bolster observations that QN resistance is a complex trait requiring the contribution of multiple transporter proteins. ..
  72. Dahlström S, Ferreira P, Veiga M, Sedighi N, Wiklund L, Martensson A, et al. Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa. J Infect Dis. 2009;200:1456-64 pubmed publisher
    ..Our data suggest for the first time, to our knowledge, the involvement of pfMRP1 in P. falciparum in vivo response to ACT. ..
  73. Ridzuan M, Moon R, Knuepfer E, Black S, Holder A, Green J. Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development. PLoS ONE. 2012;7:e33845 pubmed publisher
    ..The early assembly of the motor complex suggests that it has functions in addition to its role in erythrocyte invasion. ..
  74. Ruecker A, Shea M, Hackett F, Suarez C, Hirst E, Milutinovic K, et al. Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte. J Biol Chem. 2012;287:37949-63 pubmed publisher
    ..Our observations reveal a proteolytic activation step in the malarial PV that may be required for release of the parasite from its host erythrocyte. ..
  75. Jones M, Cottingham C, Rayner J. Effects of calcium signaling on Plasmodium falciparum erythrocyte invasion and post-translational modification of gliding-associated protein 45 (PfGAP45). Mol Biochem Parasitol. 2009;168:55-62 pubmed publisher
    ..falciparum erythrocyte invasion and reveals that the assembly status of the merozoite glideosome, which is central to erythrocyte invasion, is surprisingly dynamic. ..
  76. Gupta A, Mehra P, Deshmukh A, Dar A, Mitra P, Roy N, et al. Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparum. Eukaryot Cell. 2009;8:1341-51 pubmed publisher
    ..These results not only provide us a useful system to study the function of the essential genes in Plasmodium, they help us to identify the previously undiscovered unique features of replication proteins in general. ..
  77. Hu G, Cabrera A, Kono M, Mok S, Chaal B, Haase S, et al. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol. 2010;28:91-8 pubmed publisher
    ..Our network may facilitate identification of novel antimalarial drugs and vaccines. ..
  78. Crosnier C, Bustamante L, Bartholdson S, Bei A, Theron M, Uchikawa M, et al. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature. 2011;480:534-7 pubmed publisher
    ..Our discovery of a cross-strain dependency on a single extracellular receptor-ligand pair for erythrocyte invasion by P. falciparum provides a focus for new anti-malarial therapies. ..
  79. Dearnley M, Yeoman J, Hanssen E, Kenny S, Turnbull L, Whitchurch C, et al. Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes. J Cell Sci. 2012;125:2053-63 pubmed publisher
  80. Eshar S, Allemand E, Sebag A, Glaser F, Muchardt C, Mandel Gutfreund Y, et al. A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes. Nucleic Acids Res. 2012;40:9903-16 pubmed publisher
    ..Finally, we demonstrate that proper regulation of pfsr1 is required for parasite proliferation in human RBCs and over-expression of pfsr1 influences AS activity of P. falciparum genes in vivo. ..
  81. Lin D, Malpede B, Batchelor J, Tolia N. Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion. J Biol Chem. 2012;287:36830-6 pubmed publisher
    ..falciparum invasion ligands. A complete understanding of the PfEBA-140 erythrocyte invasion pathway will aid in the design of invasion inhibitory therapeutics and vaccines. ..
  82. Zuccala E, Gout A, Dekiwadia C, Marapana D, Angrisano F, Turnbull L, et al. Subcompartmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasite. PLoS ONE. 2012;7:e46160 pubmed publisher
  83. Simon N, Lasonder E, Scheuermayer M, Kuehn A, Tews S, Fischer R, et al. Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe. 2013;13:29-41 pubmed publisher
    ..Thus, Plasmodium co-opts the protective host protein FH to evade complement-mediated lysis within the mosquito midgut. ..
  84. Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois A, Khim N, et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature. 2014;505:50-5 pubmed publisher
    ..K13-propeller polymorphism constitutes a useful molecular marker for large-scale surveillance efforts to contain artemisinin resistance in the Greater Mekong Subregion and prevent its global spread. ..
  85. Holland Z, Prudent R, Reiser J, Cochet C, Doerig C. Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum. Eukaryot Cell. 2009;8:388-97 pubmed publisher
    ..falciparum CK2alpha enzymes to a small molecule inhibitor. Taken together, our data identify PfCK2alpha as a potential target for antimalarial chemotherapeutic intervention. ..
  86. Engelmann S, Silvie O, Matuschewski K. Disruption of Plasmodium sporozoite transmission by depletion of sporozoite invasion-associated protein 1. Eukaryot Cell. 2009;8:640-8 pubmed publisher
    ..We propose that arthropod-transmitted apicomplexan parasites specifically express secretory factors, such as SIAP-1, that mediate efficient oocyst exit and migration to the salivary glands. ..
  87. Farooq U, Malla N, Dubey M. Genetic polymorphism in msp-2, ama-1 and csp genes in Plasmodium falciparum field isolates from north and north-western India. J Vector Borne Dis. 2009;46:109-16 pubmed
    ..The low level transmission of malaria in the study area may also be a factor for low polymorphism. ..
  88. de Koning Ward T, Gilson P, Boddey J, Rug M, Smith B, Papenfuss A, et al. A newly discovered protein export machine in malaria parasites. Nature. 2009;459:945-9 pubmed publisher
    ..Two other proteins, a new protein PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components. As a common portal for numerous crucial processes, this translocon offers a new avenue for therapeutic intervention. ..
  89. Pang C, Hunter J, Gujjar R, Podutoori R, Bowman J, Mudeppa D, et al. Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase. Mol Biochem Parasitol. 2009;168:74-83 pubmed publisher
    ..coli but found to be inactive. This protein, nor DHFR-TS, enhanced the catalytic activity of PfSHMT. The present results set the stage for developing specific, potent inhibitors of SHMT from P. falciparum. ..
  90. Flueck C, Bartfai R, Niederwieser I, Witmer K, Alako B, Moes S, et al. A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. PLoS Pathog. 2010;6:e1000784 pubmed publisher
    ..These findings are highly relevant for our understanding of chromosome end biology and variegated expression in P. falciparum and other eukaryotes, and for the future analysis of the role of ApiAP2-DNA interactions in parasite biology. ..
  91. Valderramos S, Valderramos J, Musset L, Purcell L, Mercereau Puijalon O, Legrand E, et al. Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum. PLoS Pathog. 2010;6:e1000887 pubmed publisher
  92. Chu T, Lingelbach K, Przyborski J. Genetic evidence strongly support an essential role for PfPV1 in intra-erythrocytic growth of P. falciparum. PLoS ONE. 2011;6:e18396 pubmed publisher
    ..Our data provide strong genetic evidence that PfPV1 is essential for survival of blood stage P. falciparum, and further highlight the importance of parasitophorous vacuole proteins in this part of the parasite's life cycle. ..