Cryptosporidium parvum Iowa II


Alias: Cryptosporidium parvum strain Iowa type II

Top Publications

  1. Buchko G, Abendroth J, Clifton M, Robinson H, Zhang Y, Hewitt S, et al. Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis. Acta Crystallogr F Struct Biol Commun. 2015;71:522-30 pubmed publisher
    ..While robust, Cp-CutA1 is not as stable as the homologous protein from a hyperthermophile, perhaps owing to a wide β-bulge in β2 that protrudes Pro48 and Ser49 outside the β-sheet. ..
  2. Matsubayashi M, Teramoto Kimata I, Uni S, Lillehoj H, Matsuda H, Furuya M, et al. Elongation factor-1? is a novel protein associated with host cell invasion and a potential protective antigen of Cryptosporidium parvum. J Biol Chem. 2013;288:34111-20 pubmed publisher
    ..These results indicate that C. parvum EF-1? plays an essential role in mediating host cell entry by the parasite and, as such, could be a candidate vaccine antigen against cryptosporidiosis. ..
  3. Na B, Kang J, Cheun H, Cho S, Moon S, Kim T, et al. Cryptopain-1, a cysteine protease of Cryptosporidium parvum, does not require the pro-domain for folding. Parasitology. 2009;136:149-57 pubmed publisher
    ..This suggested a probable role for cryptopain-1 in host cell invasion and/or egression by the parasite. ..
  4. Liang R, Morris P, Cho S, Abud H, Jin X, Cheng W. Hedgehog signaling displays a biphasic expression pattern during intestinal injury and repair. J Pediatr Surg. 2012;47:2251-63 pubmed publisher
    ..Hedgehog signaling pathway displays a biphasic expression pattern during the injury/repair of small intestine. It may play an important regulatory role in intestinal repair. ..
  5. Liu C, Wang L, Lancto C, Abrahamsen M. Characterization of a Cryptosporidium parvum protein that binds single-stranded G-strand telomeric DNA. Mol Biochem Parasitol. 2009;165:132-41 pubmed publisher
    ..And the minimal sequence necessary for CpGbp's binding is "GTTTAGGTTTAG". These data support the notion that CpGbp represents a C. parvum single-stranded telomeric DNA binding protein. ..
  6. Ordoñez C, Alfonso J, Balaña Fouce R, Ordóñez D. Functional expression of a DNA-topoisomerase IB from Cryptosporidium parvum. J Biomed Biotechnol. 2009;2009:837608 pubmed publisher
    ..The susceptibility of CpTopIB-transformed yeast to the irreversible inhibitor camptothecin and its water-soluble derivatives (topotecan and SN-38) was assessed. ..
  7. Valentini E, Cherchi S, Possenti A, Dubremetz J, Pozio E, Spano F. Molecular characterisation of a Cryptosporidium parvum rhoptry protein candidate related to the rhoptry neck proteins TgRON1 of Toxoplasma gondii and PfASP of Plasmodium falciparum. Mol Biochem Parasitol. 2012;183:94-9 pubmed publisher
    ..Our data strongly suggest a rhoptry localization for the newly characterised protein, which was therefore renamed C. parvum putative rhoptry protein-1 (CpPRP1). ..
  8. Kang J, Ju H, Sohn W, Na B. Molecular cloning and characterization of a M17 leucine aminopeptidase of Cryptosporidium parvum. Parasitology. 2011;138:682-90 pubmed publisher
    ..These results collectively suggest that CpLAP is a typical member of the M17 LAP family and may play an important role in free amino acid regulation in the parasite. ..
  9. Yarlett N, Wu G, Waters W, Harp J, Wannemuehler M, Morada M, et al. Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme. Mol Biochem Parasitol. 2007;152:170-80 pubmed
    ..The results of this study reveal that the C. parvum SSAT may provide a rational target for drug design. ..

More Information


  1. Paluszynski J, Monahan Z, Williams M, Lai O, Morris C, Burns P, et al. Biochemical and functional characterization of CpMuc4, a Cryptosporidium surface antigen that binds to host epithelial cells. Mol Biochem Parasitol. 2014;193:114-21 pubmed publisher
    ..T. gondii recombinant CpMuc4 may mimic the native antigen well enough to serve as a useful tool for identifying the host cell receptor and determining the role of native CpMuc4 in host cell invasion. ..
  2. Kang J, Ju H, Sohn W, Na B. Characterization of biochemical properties of a selenium-independent glutathione peroxidase of Cryptosporidium parvum. Parasitology. 2014;141:570-8 pubmed publisher
    ..parvum. These results collectively suggest the essential role of CpGPx for the parasite's antioxidant defence system. ..
  3. Cook W, Senkovich O, Aleem K, Chattopadhyay D. Crystal structure of Cryptosporidium parvum pyruvate kinase. PLoS ONE. 2012;7:e46875 pubmed publisher
    ..Both cysteine residues are unique to C. parvum, and the disulfide bond remained intact in a reduced environment. However, the significance of this bond, if any, remains unknown at this time. ..
  4. Nguyen T, Abendroth J, Leibly D, Le K, Guo W, Kelley A, et al. Structure of triosephosphate isomerase from Cryptosporidium parvum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:1095-9 pubmed publisher
    ..In this paper, the 1.55 Å resolution crystal structure of the open-loop form of triosephosphate isomerase from C. parvum Iowa II is presented. An unidentified electron density was found in the active site. ..
  5. Wanyiri J, Techasintana P, O Connor R, Blackman M, Kim K, Ward H. Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro. Eukaryot Cell. 2009;8:470-7 pubmed publisher
    ..parvum infection of HCT-8 cells. These studies indicate that CpSUB1 plays a significant role in infection of host cells by the parasite and suggest that this enzyme may serve as a target for intervention. ..
  6. MacPherson I, Kirubakaran S, Gorla S, Riera T, D Aquino J, Zhang M, et al. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. J Am Chem Soc. 2010;132:1230-1 pubmed publisher
    ..Using this information, we have synthesized low-nanomolar inhibitors that display 10(3) selectivity for the parasite enzyme over human IMPDH2...
  7. Tsugeki R, Ditengou F, Sumi Y, Teale W, Palme K, Okada K. NO VEIN mediates auxin-dependent specification and patterning in the Arabidopsis embryo, shoot, and root. Plant Cell. 2009;21:3133-51 pubmed publisher
    ..We propose that NOV mediates the acquisition of competence to undergo auxin-dependent coordinated cell specification and patterning, thereby eliciting context-dependent auxin-mediated developmental responses...
  8. O Connor R, Burns P, Ha Ngoc T, Scarpato K, Khan W, Kang G, et al. Polymorphic mucin antigens CpMuc4 and CpMuc5 are integral to Cryptosporidium parvum infection in vitro. Eukaryot Cell. 2009;8:461-9 pubmed publisher
    ..Sequencing of CpMuc4 and CpMuc5 from C. hominis clinical isolates identified several polymorphic alleles. The data suggest that these antigens are integral for Cryptosporidium infection in vitro and may be potential vaccine candidates...
  9. Rider S, Zhu G. Differential expression of the two distinct replication protein A subunits from Cryptosporidium parvum. J Cell Biochem. 2008;104:2207-16 pubmed publisher
    ..Collectively, our data implies that the two RPA1 proteins in C. parvum are performing different roles during DNA replication, repair and recombination in this parasite...
  10. Putignani L, Possenti A, Cherchi S, Pozio E, Crisanti A, Spano F. The thrombospondin-related protein CpMIC1 (CpTSP8) belongs to the repertoire of micronemal proteins of Cryptosporidium parvum. Mol Biochem Parasitol. 2008;157:98-101 pubmed publisher
    ..Accordingly, double immunofluorescence localized CpTSP8 to C. parvum micronemes, prompting us to rename it CpMIC1 in agreement with the current MICs nomenclature...
  11. Fritzler J, Millership J, Zhu G. Cryptosporidium parvum long-chain fatty acid elongase. Eukaryot Cell. 2007;6:2018-28 pubmed publisher
    ..e., maximum inhibitions of 20.5% and 32.7% were observed when C16:0 and C14:0 were used as substrates, respectively). These observations ultimately validate the function of CpLCE1...
  12. Rider S, Cai X, Sullivan W, Smith A, Radke J, White M, et al. The protozoan parasite Cryptosporidium parvum possesses two functionally and evolutionarily divergent replication protein A large subunits. J Biol Chem. 2005;280:31460-9 pubmed publisher
    ..Differential expression during the life cycle stages in three apicomplexan parasites suggests that the two RPA1 types exercise specialized biological functions...
  13. Merritt E, Arakaki T, Gillespie R, Napuli A, Kim J, Buckner F, et al. Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol Biochem Parasitol. 2011;177:20-8 pubmed publisher
    ..Together with a previously reported structure of an unusual TrpRS from Giardia, these protozoan structures broaden our perspective on the extent of structural variation found in eukaryotic TrpRS homologs...