Babesia bovis T2Bo
Begley D, Edwards T, Raymond A, Smith E, Hartley R, Abendroth J, et al
. Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:1070-7 pubmed publisher
..The complexes reveal modes of binding similar to that seen in drug-resistant malaria strains and point to the utility of applying structural studies with proven cancer chemotherapies towards infectious disease research. ..
Ueno A, Terkawi M, Yokoyama M, Cao S, Aboge G, Aboulaila M, et al
. Farsenyl pyrophosphate synthase is a potential molecular drug target of risedronate in Babesia bovis. Parasitol Int. 2013;62:189-92 pubmed publisher
..02±0.91?M). No regrowth of B. bovis was observed at 10?M of risedronate in the subsequent viability test. These results demonstrate that BbFPPS is the molecular target of risedronate, which could inhibit the in vitro growth of B. bovis. ..
Regner E, Thompson C, Iglesias A, Guerrero S, Arias D. Biochemical characterization of thioredoxin reductase from Babesia bovis. Biochimie. 2014;99:44-53 pubmed publisher
..We have performed an enzymatic characterization, searching for targets for rational design of inhibitors. This work contributes to the better understanding of the redox biochemistry occurring in the parasite. ..
Derbyshire E, Franssen F, de Vries E, Morin C, Woodrow C, Krishna S, et al
. Identification, expression and characterisation of a Babesia bovis hexose transporter. Mol Biochem Parasitol. 2008;161:124-9 pubmed publisher
..Taken together with results of inhibition studies with cytochalasin B and beta-glucogallin, these data provide new insights into glucose metabolism of erythrocytic-stage Babesia infections...
Wang X, Xiao Y, Bouchut A, Al Khedery B, Wang H, Allred D. Characterization of the unusual bidirectional ves promoters driving VESA1 expression and associated with antigenic variation in Babesia bovis. Eukaryot Cell. 2012;11:260-9 pubmed publisher
..These results provide a framework to help us begin to understand gene regulation during antigenic variation in B. bovis...