Caulobacter crescentus CB15

Summary

Alias: Caulobacter crescentus str. CB15, Caulobacter vibrioides CB15, Caulobacter crescentus CB 15, Caulobacter crescentus strain CB15, Caulobacter vibrioides ATCC 19089

Top Publications

  1. Alley M, Maddock J, Shapiro L. Polar localization of a bacterial chemoreceptor. Genes Dev. 1992;6:825-36 pubmed
  2. Wang S, Sharma P, Schoenlein P, Ely B. A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus. Proc Natl Acad Sci U S A. 1993;90:630-4 pubmed
    ..The use of a phosphorelay system cued to internal changes in the cell would provide a mechanism for coordinating major changes in gene expression with the completion of specific cell cycle events. ..
  3. Jenal U, Fuchs T. An essential protease involved in bacterial cell-cycle control. EMBO J. 1998;17:5658-69 pubmed
    ..In particular, CtrA negatively controls DNA replication and our findings suggest that specific degradation of the CtrA protein by the ClpXP protease contributes to G1-to-S transition in this organism. ..
  4. Pierce D, O Donnol D, Allen R, Javens J, Quardokus E, Brun Y. Mutations in DivL and CckA rescue a divJ null mutant of Caulobacter crescentus by reducing the activity of CtrA. J Bacteriol. 2006;188:2473-82 pubmed
    ..In vivo phosphorylation assays confirmed that divJ mutants have elevated levels of CtrA phosphorylation and that this level is reduced in the suppressors with mutations in divL. ..
  5. Roberts R, Toochinda C, Avedissian M, Baldini R, Gomes S, Shapiro L. Identification of a Caulobacter crescentus operon encoding hrcA, involved in negatively regulating heat-inducible transcription, and the chaperone gene grpE. J Bacteriol. 1996;178:1829-41 pubmed
  6. Mohl D, Gober J. Cell cycle-dependent polar localization of chromosome partitioning proteins in Caulobacter crescentus. Cell. 1997;88:675-84 pubmed
    ..These results suggest that ParA and ParB are involved in partitioning newly replicated chromosomes to the poles of the predivisional cell and may function as components of a bacterial mitotic apparatus. ..
  7. Sackett M, Kelly A, Brun Y. Ordered expression of ftsQA and ftsZ during the Caulobacter crescentus cell cycle. Mol Microbiol. 1998;28:421-34 pubmed
    ..Thus, transcription of ftsA and ftsZ mimics their order of action in Caulobacter and proper transcription of ftsA has to be maintained for normal cell division and differentiation. ..
  8. Ausmees N, Kuhn J, Jacobs Wagner C. The bacterial cytoskeleton: an intermediate filament-like function in cell shape. Cell. 2003;115:705-13 pubmed
    ..We propose that IF-like filaments of crescentin assemble into a helical structure, which by applying its geometry to the cell, generates a vibrioid or helical cell shape depending on the length of the cell. ..
  9. Martin M, Trimble M, Brun Y. Cell cycle-dependent abundance, stability and localization of FtsA and FtsQ in Caulobacter crescentus. Mol Microbiol. 2004;54:60-74 pubmed

More Information

Publications127 found, 100 shown here

  1. Gitai Z, Dye N, Reisenauer A, Wachi M, Shapiro L. MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell. 2005;120:329-41 pubmed
    ..MreB selectively interacts, directly or indirectly, with origin-proximal regions of the chromosome, arguing that the origin-proximal region segregates via an MreB-dependent mechanism not used by the rest of the chromosome. ..
  2. Biondi E, Reisinger S, Skerker J, Arif M, Perchuk B, Ryan K, et al. Regulation of the bacterial cell cycle by an integrated genetic circuit. Nature. 2006;444:899-904 pubmed
    ..Our results define a single integrated circuit whose components and connectivity can account for the cell cycle oscillations of CtrA in Caulobacter. ..
  3. Li Z, Trimble M, Brun Y, Jensen G. The structure of FtsZ filaments in vivo suggests a force-generating role in cell division. EMBO J. 2007;26:4694-708 pubmed
  4. Ebersbach G, Briegel A, Jensen G, Jacobs Wagner C. A self-associating protein critical for chromosome attachment, division, and polar organization in caulobacter. Cell. 2008;134:956-68 pubmed publisher
    ..Instead, evidence suggests that localization of PopZ largely relies on PopZ multimerization in chromosome-free regions, consistent with a self-organizing mechanism. ..
  5. Bowman G, Comolli L, Gaietta G, Fero M, Hong S, Jones Y, et al. Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function. Mol Microbiol. 2010;76:173-89 pubmed publisher
    ..We propose that pole-specific control of PopZ function co-ordinates polar development and cell cycle progression by enabling independent assembly and tethering activities at the two cell poles. ..
  6. Holtzendorff J, Hung D, Brende P, Reisenauer A, Viollier P, McAdams H, et al. Oscillating global regulators control the genetic circuit driving a bacterial cell cycle. Science. 2004;304:983-7 pubmed
    ..CtrA functions as a silencer of the replication origin and GcrA as an activator of components of the replisome and the segregation machinery. ..
  7. Gorbatyuk B, Marczynski G. Regulated degradation of chromosome replication proteins DnaA and CtrA in Caulobacter crescentus. Mol Microbiol. 2005;55:1233-45 pubmed
    ..This unexpected and finely tuned proteolysis system may be an important adaptation for a developmental bacterium that is often challenged by nutrient-poor environments. ..
  8. Aaron M, Charbon G, Lam H, Schwarz H, Vollmer W, Jacobs Wagner C. The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus. Mol Microbiol. 2007;64:938-52 pubmed
    ..Evidence suggests that bacteria use both a FtsZ-independent and a FtsZ-dependent mode of peptidoglycan synthesis to elongate, the importance of each mode depending on the timing of FtsZ assembly during elongation. ..
  9. Bowman G, Comolli L, Zhu J, Eckart M, Koenig M, Downing K, et al. A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole. Cell. 2008;134:945-55 pubmed publisher
  10. Wagner J, Galvani C, Brun Y. Caulobacter crescentus requires RodA and MreB for stalk synthesis and prevention of ectopic pole formation. J Bacteriol. 2005;187:544-53 pubmed
    ..We conclude that MreB, RodA, and the target(s) of amdinocillin all contribute to the maintenance of cellular polarity in C. crescentus...
  11. Quon K, Marczynski G, Shapiro L. Cell cycle control by an essential bacterial two-component signal transduction protein. Cell. 1996;84:83-93 pubmed
  12. Lo T, van Der Schalie E, Werner T, Brun Y, Din N. A temperature-sensitive mutation in the dnaE gene of Caulobacter crescentus that prevents initiation of DNA replication but not ongoing elongation of DNA. J Bacteriol. 2004;186:1205-12 pubmed
  13. McGrath P, Iniesta A, Ryan K, Shapiro L, McAdams H. A dynamically localized protease complex and a polar specificity factor control a cell cycle master regulator. Cell. 2006;124:535-47 pubmed
    ..Thus, a dynamically localized ClpXP proteolysis complex in concert with a cytoplasmic factor provides temporal and spatial specificity to protein degradation during a bacterial cell cycle...
  14. Thanbichler M, Shapiro L. MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter. Cell. 2006;126:147-62 pubmed
    ..The cellular localization of MipZ thus serves the dual function of positioning the FtsZ ring and delaying formation of the cell division apparatus until chromosome segregation has initiated...
  15. Iniesta A, Hillson N, Shapiro L. Cell pole-specific activation of a critical bacterial cell cycle kinase. Proc Natl Acad Sci U S A. 2010;107:7012-7 pubmed publisher
    ..Because DivL and CckA accumulate at the same cell pole after the initiation of DNA replication and were found to interact in vivo, we propose that DivL recruits CckA to the pole, thereby promoting its autophosphorylation and activity...
  16. Gober J, Boyd C, Jarvis M, Mangan E, Rizzo M, Wingrove J. Temporal and spatial regulation of fliP, an early flagellar gene of Caulobacter crescentus that is required for motility and normal cell division. J Bacteriol. 1995;177:3656-67 pubmed
    ..Later in the cell cycle, orfX-fliP expression occurs in both poles of the predivisional cell. Protein fusions to a lacZ reporter gene indicate that FliP is specifically targeted to the swarmer compartment of the predivisional cell. ..
  17. Louren o R, Kohler C, Gomes S. A two-component system, an anti-sigma factor and two paralogous ECF sigma factors are involved in the control of general stress response in Caulobacter crescentus. Mol Microbiol. 2011;80:1598-612 pubmed publisher
    ..In conclusion, this report describes the molecular mechanism involved in the control of general stress response in C. crescentus...
  18. Fisher J, Smit J, Agabian N. Transcriptional analysis of the major surface array gene of Caulobacter crescentus. J Bacteriol. 1988;170:4706-13 pubmed
    The major component of the paracrystalline surface array of Caulobacter crescentus CB15 and one of the most abundant cellular proteins is a protein designated 130K...
  19. Hecht G, Lane T, Ohta N, Sommer J, Newton A. An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus. EMBO J. 1995;14:3915-24 pubmed
    ..We suggest that phosphotransfer mediated by these two-component signal transduction systems may represent a general mechanism regulating cell differentiation and cell division in response to successive cell cycle checkpoints...
  20. Fuchs T, Wiget P, Oster s M, Jenal U. Precise amounts of a novel member of a phosphotransferase superfamily are essential for growth and normal morphology in Caulobacter crescentus. Mol Microbiol. 2001;39:679-92 pubmed
  21. Simão R, Susin M, Alvarez Martinez C, Gomes S. Cells lacking ClpB display a prolonged shutoff phase of the heat shock response in Caulobacter crescentus. Mol Microbiol. 2005;57:592-603 pubmed
    ..Our findings also indicated that the absence of ClpB made cells more sensitive to heat shock and ethanol but not to other stresses, and unable to acquire thermotolerance. ..
  22. Fernandez Fernandez C, Grosse K, Sourjik V, Collier J. The ?-sliding clamp directs the localization of HdaA to the replisome in Caulobacter crescentus. Microbiology. 2013;159:2237-48 pubmed publisher
    ..The AAA+ domain of HdaA may therefore be required during RIDA after the initial recruitment of HdaA to the replisome by DnaN. ..
  23. Wu J, Ohta N, Newton A. An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter. Proc Natl Acad Sci U S A. 1998;95:1443-8 pubmed
    ..Our results suggest that an unidentified phosphotransfer protein or kinase (X) is responsible for phosphoryl group transfer to CtrA in the proposed DivJ --> DivK --> X --> CtrA phosphorelay pathway...
  24. Jacobs C, Domian I, Maddock J, Shapiro L. Cell cycle-dependent polar localization of an essential bacterial histidine kinase that controls DNA replication and cell division. Cell. 1999;97:111-20 pubmed
    ..Thus, dynamic changes in cellular location of critical signal proteins provide a novel mechanism for the control of the prokaryote cell cycle...
  25. Ely B, Ely T, Crymes W, Minnich S. A family of six flagellin genes contributes to the Caulobacter crescentus flagellar filament. J Bacteriol. 2000;182:5001-4 pubmed
    ..Since these flagellins are the first to be assembled in the flagellar filament, one or both might have specialized to facilitate the initiation of filament assembly...
  26. Cabantous S, Guillet V, Ohta N, Newton A, Samama J. Characterization and crystallization of DivK, an essential response regulator for cell division and differentiation in Caulobacter crescentus. Acta Crystallogr D Biol Crystallogr. 2002;58:1249-51 pubmed
    ..These crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 37.2, b = 40.5, c = 67.1 A and diffract beyond 1.6 A on a synchrotron beamline...
  27. Wan Z, Brown P, Elliott E, Brun Y. The adhesive and cohesive properties of a bacterial polysaccharide adhesin are modulated by a deacetylase. Mol Microbiol. 2013;88:486-500 pubmed publisher
    ..We conclude that the polysaccharide deacetylase activity of HfsH is required for the adhesive and cohesive properties of the holdfast, as well as for the anchoring of the holdfast to the cell envelope...
  28. Taberman H, Andberg M, Koivula A, Hakulinen N, Penttilä M, Rouvinen J, et al. Structure and function of Caulobacter crescentus aldose-aldose oxidoreductase. Biochem J. 2015;472:297-307 pubmed publisher
    Aldose-aldose oxidoreductase (Cc AAOR) is a recently characterized enzyme from the bacterial strain Caulobacter crescentus CB15 belonging to the glucose-fructose oxidoreductase/inositol dehydrogenase/rhizopine catabolism protein (Gfo/Idh/..
  29. Tarleton J, Malakooti J, Ely B. Regulation of Caulobacter crescentus ilvBN gene expression. J Bacteriol. 1994;176:3765-74 pubmed
    ..Thus, it appears that C. crescentus uses attenuation to regulate the expression of the ilvBN operon...
  30. Rava P, Somma L, Steinman H. Identification of a regulator that controls stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. J Bacteriol. 1999;181:6152-9 pubmed
  31. Ford M, Nomellini J, Smit J. S-layer anchoring and localization of an S-layer-associated protease in Caulobacter crescentus. J Bacteriol. 2007;189:2226-37 pubmed publisher
    ..Moreover, Sap was secreted to the cell surface primarily by the S-layer type I secretion apparatus...
  32. Irnov I, Wang Z, Jannetty N, Bustamante J, Rhee K, Jacobs Wagner C. Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of ?-ketoglutarate. PLoS Genet. 2017;13:e1006978 pubmed publisher
  33. Marczynski G, Shapiro L. Cell-cycle control of a cloned chromosomal origin of replication from Caulobacter crescentus. J Mol Biol. 1992;226:959-77 pubmed
    ..The latter two motifs are implicated in essential C. crescentus replication functions, because they are contained within specific deletions that abolish replication...
  34. Ohta N, Mullin D, Tarleton J, Ely B, Newton A. Identification, distribution, and sequence analysis of new insertion elements in Caulobacter crescentus. J Bacteriol. 1990;172:236-42 pubmed
    ..IS298 contains an imperfect terminal inverted repeat 16 bp long, and IS511 contains a 32-bp inverted repeat at the termini. IS298 and IS511 are the first insertion elements described in C. crescentus. ..
  35. Smit J, Agabian N. Cloning of the major protein of the Caulobacter crescentus periodic surface layer: detection and characterization of the cloned peptide by protein expression assays. J Bacteriol. 1984;160:1137-45 pubmed
    A precisely ordered crystalline array is found on the surface of the bacterium Caulobacter crescentus CB15. Using an immunological assay, we identified recombinant bacteriophage clones expressing the predominant protein of this structure ..
  36. Mullin D, Zies D, Mullin A, Caballera N, Ely B. Genetic organization and transposition properties of IS511. Mol Gen Genet. 1997;254:456-63 pubmed
    IS511 is an endogenous insertion sequence (IS) of the bacterium Caulobacter crescentus strain CB15 and it is the first Caulobacter IS to be characterized at the molecular level...
  37. Stephens C, Mohr C, Boyd C, Maddock J, Gober J, Shapiro L. Identification of the fliI and fliJ components of the Caulobacter flagellar type III protein secretion system. J Bacteriol. 1997;179:5355-65 pubmed
    ..Mutational analysis of FliI showed that two highly conserved amino acid residues in a bipartite ATP binding motif are necessary for flagellar assembly...
  38. Guillet V, Ohta N, Cabantous S, Newton A, Samama J. Crystallographic and biochemical studies of DivK reveal novel features of an essential response regulator in Caulobacter crescentus. J Biol Chem. 2002;277:42003-10 pubmed publisher
  39. Shen Y, Goldsmith Fischman S, Atreya H, Acton T, Ma L, Xiao R, et al. NMR structure of the 18 kDa protein CC1736 from Caulobacter crescentus identifies a member of the START domain superfamily and suggests residues mediating substrate specificity. Proteins. 2005;58:747-50 pubmed
  40. Sciochetti S, Ohta N, Newton A. The role of polar localization in the function of an essential Caulobacter crescentus tyrosine kinase. Mol Microbiol. 2005;56:1467-80 pubmed publisher
    ..Thus, subcellular localization of DivL is not essential to its function in cell division regulation. Regulation of cell division by DivL does, however, depend on its localization in the cell membrane...
  41. Susin M, Baldini R, Gueiros Filho F, Gomes S. GroES/GroEL and DnaK/DnaJ have distinct roles in stress responses and during cell cycle progression in Caulobacter crescentus. J Bacteriol. 2006;188:8044-53 pubmed publisher
    ..Thus, the two chaperone systems have distinct roles in stress responses and during cell cycle progression in C. crescentus...
  42. Wassmann P, Chan C, Paul R, Beck A, Heerklotz H, Jenal U, et al. Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition. Structure. 2007;15:915-27 pubmed publisher
    ..Here, a second mode is observed that crosslinks the DGC domains within a PleD dimer. Both modes cause noncompetitive product inhibition by domain immobilization...
  43. Louren o R, Gomes S. The transcriptional response to cadmium, organic hydroperoxide, singlet oxygen and UV-A mediated by the sigmaE-ChrR system in Caulobacter crescentus. Mol Microbiol. 2009;72:1159-70 pubmed publisher
    ..Furthermore, deletion of rpoE and two sigma(E)-dependent genes (cfaS and hsp20) impairs Caulobacter survival when singlet oxygen is constantly generated in the cells...
  44. Taylor J, Wilbur J, Smith S, Ryan K. Mutations that alter RcdA surface residues decouple protein localization and CtrA proteolysis in Caulobacter crescentus. J Mol Biol. 2009;394:46-60 pubmed publisher
    ..Our results argue that RcdA stimulates CtrA proteolysis neither by localizing CtrA at the cell pole nor by preventing competition from SsrA-tagged substrates. ..
  45. Vass R, Chien P. Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus. Proc Natl Acad Sci U S A. 2013;110:18138-43 pubmed publisher
    ..The conservation of distinct DnaX isoforms throughout bacteria despite fundamentally different mechanisms for producing them suggests there may be a conserved need for alternate clamp loader complexes during DNA damaging conditions. ..
  46. Gilchrist A, Fisher J, Smit J. Nucleotide sequence analysis of the gene encoding the Caulobacter crescentus paracrystalline surface layer protein. Can J Microbiol. 1992;38:193-202 pubmed
    ..RsaA protein also shared some homology with 10 other S-layer proteins, with the Campylobacter fetus S-layer protein scoring highest...
  47. Kurtz H, Smit J, Smith J. The Caulobacter crescentus holdfast: identification of holdfast attachment complex genes. FEMS Microbiol Lett. 1994;116:175-82 pubmed
  48. Avedissian M, Lopes Gomes S. Expression of the groESL operon is cell-cycle controlled in Caulobacter crescentus. Mol Microbiol. 1996;19:79-89 pubmed
    ..crescentus groESL expression...
  49. Winzeler E, Shapiro L. Translation of the leaderless Caulobacter dnaX mRNA. J Bacteriol. 1997;179:3981-8 pubmed
    ..We propose that translation of leaderless mRNAs may provide a mechanism by which the ribosome can distinguish between productive and nonproductive templates...
  50. Ward D, Newton A. Requirement of topoisomerase IV parC and parE genes for cell cycle progression and developmental regulation in Caulobacter crescentus. Mol Microbiol. 1997;26:897-910 pubmed
  51. Lam H, Schofield W, Jacobs Wagner C. A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell. Cell. 2006;124:1011-23 pubmed publisher
    ..Localization defects of the actin-like protein MreB in the DeltatipN mutant suggest that TipN is upstream of MreB in regulating cell polarity...
  52. Brun Y, Shapiro L. A temporally controlled sigma-factor is required for polar morphogenesis and normal cell division in Caulobacter. Genes Dev. 1992;6:2395-408 pubmed
  53. Ohta N, Chen L, Swanson E, Newton A. Transcriptional regulation of a periodically controlled flagellar gene operon in Caulobacter crescentus. J Mol Biol. 1985;186:107-15 pubmed
  54. Oster s M, Stotz A, Schmid Nuoffer S, Jenal U. Identification and transcriptional control of the genes encoding the Caulobacter crescentus ClpXP protease. J Bacteriol. 1999;181:3039-50 pubmed
    ..crescentus. Determination of the numbers of ClpP and ClpX molecules per cell suggested that ClpX is the limiting component compared with ClpP...
  55. Wu J, Ohta N, Zhao J, Newton A. A novel bacterial tyrosine kinase essential for cell division and differentiation. Proc Natl Acad Sci U S A. 1999;96:13068-73 pubmed
    ..DivL is the only reported HPK homologue whose function has been shown to require autophosphorylation on a tyrosine, and, thus, it represents a new class of kinases within this superfamily of protein kinases...
  56. Anderson P, Gober J. FlbT, the post-transcriptional regulator of flagellin synthesis in Caulobacter crescentus, interacts with the 5' untranslated region of flagellin mRNA. Mol Microbiol. 2000;38:41-52 pubmed
    ..Interestingly, the mutant transcript that failed to associate with FlbT in vitro was still repressed in mutants defective in flagellum assembly, suggesting that other factors in addition to FlbT couple assembly to translation...
  57. Muir R, Gober J. Regulation of FlbD activity by flagellum assembly is accomplished through direct interaction with the trans-acting factor, FliX. Mol Microbiol. 2004;54:715-30 pubmed publisher
  58. Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi E, et al. Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate. Cell. 2008;133:452-61 pubmed publisher
    ..crescentus. Thus, single domain response regulators can facilitate crosstalk, feedback control, and long-range communication among members of the two-component network...
  59. Toh E, Kurtz H, Brun Y. Characterization of the Caulobacter crescentus holdfast polysaccharide biosynthesis pathway reveals significant redundancy in the initiating glycosyltransferase and polymerase steps. J Bacteriol. 2008;190:7219-31 pubmed publisher
  60. Costa T, Priyadarshini R, Jacobs Wagner C. Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain. Mol Microbiol. 2008;70:634-51 pubmed publisher
    ..Collectively, our results suggest a role for PBP3 in pole morphogenesis and provide new insights into the process of peptidoglycan assembly during division...
  61. Laloux G, Jacobs Wagner C. Spatiotemporal control of PopZ localization through cell cycle-coupled multimerization. J Cell Biol. 2013;201:827-41 pubmed publisher
    ..Such coupling of protein assembly with a cell cycle-associated molecular asymmetry may represent a principle of cellular organization for controlling protein localization in both time and space...
  62. Blair J, Xu Q, Childers W, Mathews I, Kern J, Eckart M, et al. Branched signal wiring of an essential bacterial cell-cycle phosphotransfer protein. Structure. 2013;21:1590-601 pubmed publisher
    ..Importantly, a small set of conserved ChpT residues promotes signaling crosstalk and contributes to the branched signaling that activates the master regulator CtrA while inactivating the CtrA degradation signal, CpdR...
  63. Bowman G, Perez A, Ptacin J, Ighodaro E, Folta Stogniew E, Comolli L, et al. Oligomerization and higher-order assembly contribute to sub-cellular localization of a bacterial scaffold. Mol Microbiol. 2013;90:776-95 pubmed publisher
    ..Thus, PopZ undergoes multiple orders of self-assembly, and the formation of an interconnected superstructure is a key feature of polar organization in Caulobacter...
  64. Gomes S, Gober J, Shapiro L. Expression of the Caulobacter heat shock gene dnaK is developmentally controlled during growth at normal temperatures. J Bacteriol. 1990;172:3051-9 pubmed
    ..K. L. Milarski and R. I. Morimoto, Proc. Natl. Acad. Sci. USA 83:9517-9521, 1986) and in a simple bacterium, the transcription of a hsp70 gene is temporally controlled as a function of the cell cycle under normal growth conditions...
  65. Malakooti J, Ely B. Principal sigma subunit of the Caulobacter crescentus RNA polymerase. J Bacteriol. 1995;177:6854-60 pubmed
    ..coli RNA polymerase, allowing the expression of C. crescentus promoters in E. coli. Thus, the C. crescentus sigma 73 appears to have a broader specificity than does the sigma 70 of the enteric bacteria...
  66. Zhuang W, Shapiro L. Caulobacter FliQ and FliR membrane proteins, required for flagellar biogenesis and cell division, belong to a family of virulence factor export proteins. J Bacteriol. 1995;177:343-56 pubmed
    ..Transcription of the fliQR operon is initiated at a specific time in the cell cycle, and deletion analysis revealed that the minimal sequence required for transcriptional activation resides within 59 bp of the start site...
  67. Ramakrishnan G, Zhao J, Newton A. Multiple structural proteins are required for both transcriptional activation and negative autoregulation of Caulobacter crescentus flagellar genes. J Bacteriol. 1994;176:7587-600 pubmed
    ..We also discuss the requirement of multiple structural genes for regulation of levels II and III genes and suggest that fla gene expression in C. crescentus may be coupled to two checkpoints in flagellum assembly...
  68. Steinman H, Fareed F, Weinstein L. Catalase-peroxidase of Caulobacter crescentus: function and role in stationary-phase survival. J Bacteriol. 1997;179:6831-6 pubmed
  69. Simm A, Higgins C, Pullan S, Avison M, Niumsup P, Erdozain O, et al. A novel metallo-beta-lactamase, Mbl1b, produced by the environmental bacterium Caulobacter crescentus. FEBS Lett. 2001;509:350-4 pubmed
    ..The main differences between Mbl1 and L1 are in the N-terminal region...
  70. Aldridge P, Paul R, Goymer P, Rainey P, Jenal U. Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus. Mol Microbiol. 2003;47:1695-708 pubmed
    ..Possible roles for PleD and its C-terminal output domain in modulating the polar cell surface of C. crescentus are discussed...
  71. Viollier P, Shapiro L. A lytic transglycosylase homologue, PleA, is required for the assembly of pili and the flagellum at the Caulobacter crescentus cell pole. Mol Microbiol. 2003;49:331-45 pubmed
    ..In support of this, PleA was found to be present only during a short interval in the cell cycle that coincides with the assembly of the flagellum and the pilus secretion apparatus...
  72. Chan C, Paul R, Samoray D, Amiot N, Giese B, Jenal U, et al. Structural basis of activity and allosteric control of diguanylate cyclase. Proc Natl Acad Sci U S A. 2004;101:17084-9 pubmed publisher
    ..This allosteric site explains the observed noncompetitive product inhibition. We propose that product inhibition is due to domain immobilization and sets an upper limit for the concentration of this second messenger in the cell...
  73. Galhardo R, Rocha R, Marques M, Menck C. An SOS-regulated operon involved in damage-inducible mutagenesis in Caulobacter crescentus. Nucleic Acids Res. 2005;33:2603-14 pubmed publisher
    ..The mutations arising as a consequence of the activity of the imuAB dnaE2 operon are rather unusual for UV irradiation, including G:C to C:G transversions...
  74. M ll A, Thanbichler M. FtsN-like proteins are conserved components of the cell division machinery in proteobacteria. Mol Microbiol. 2009;72:1037-53 pubmed publisher
    ..coli and C. crescentus, we identified FtsN-like cell division proteins in beta- and delta-proteobacteria, suggesting that FtsN is widespread among bacteria, albeit highly variable at the sequence level...
  75. Schwartz M, Shapiro L. An SMC ATPase mutant disrupts chromosome segregation in Caulobacter. Mol Microbiol. 2011;82:1359-74 pubmed publisher
    ..In wild-type cells, ATP hydrolysis opens the SMC dimer, freeing one chromosome to segregate to the opposite pole. The loss of ATP hydrolysis causes the SMC-E1076Q dimer to remain bound to both chromosomes, inhibiting segregation...
  76. Jonas K, Liu J, Chien P, Laub M. Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA. Cell. 2013;154:623-36 pubmed publisher
    ..Our work reveals a mechanism for regulating DNA replication under adverse growth conditions. Additionally, our data indicate that unfolded proteins can actively and directly alter substrate recognition by cellular proteases...
  77. Radhakrishnan S, Thanbichler M, Viollier P. The dynamic interplay between a cell fate determinant and a lysozyme homolog drives the asymmetric division cycle of Caulobacter crescentus. Genes Dev. 2008;22:212-25 pubmed publisher
    ..The dynamic interplay between SpmX and DivK is at the heart of the molecular circuitry that sustains the Caulobacter developmental cycle...
  78. Awram P, Smit J. The Caulobacter crescentus paracrystalline S-layer protein is secreted by an ABC transporter (type I) secretion apparatus. J Bacteriol. 1998;180:3062-9 pubmed
    ..Such levels are expected for bacterial S-layer proteins but are higher than for any other known type I secretion system...
  79. Iuga M, Awram P, Nomellini J, Smit J. Comparison of S-layer secretion genes in freshwater caulobacters. Can J Microbiol. 2004;50:751-66 pubmed
    ..Finally, while all of the S-layer proteins of this subset of strains were secreted by type I mechanisms, there were significant differences in genome positions of the transporter genes that correlated with S-layer protein size...
  80. Harms A, Treuner Lange A, Schumacher D, S gaard Andersen L. Tracking of chromosome and replisome dynamics in Myxococcus xanthus reveals a novel chromosome arrangement. PLoS Genet. 2013;9:e1003802 pubmed publisher
    ..We conclude that M. xanthus chromosome arrangement and dynamics combine features from previously described systems with new features leading to a novel spatiotemporal arrangement pattern...
  81. Ramakrishnan G, Zhao J, Newton A. The cell cycle-regulated flagellar gene flbF of Caulobacter crescentus is homologous to a virulence locus (lcrD) of Yersinia pestis. J Bacteriol. 1991;173:7283-92 pubmed
  82. Hong S, Tran Q, Keiler K. Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB. Mol Microbiol. 2005;57:565-75 pubmed publisher
    ..This model explains the regulation of SsrA RNA in other bacteria, and suggests that a highly conserved regulatory mechanism controls SsrA activity...
  83. Russell J, Keiler K. Subcellular localization of a bacterial regulatory RNA. Proc Natl Acad Sci U S A. 2009;106:16405-9 pubmed publisher
    ..These results suggest a model in which tmRNA-SmpB is localized to sequester tmRNA from RNase R, and localization might also regulate tmRNA-SmpB interactions with ribosomes...
  84. Dingwall A, Garman J, Shapiro L. Organization and ordered expression of Caulobacter genes encoding flagellar basal body rod and ring proteins. J Mol Biol. 1992;228:1147-62 pubmed
    ..The sequential activation of these three subgroups of structural genes reflects the order of assembly of their gene products into the flagellum. ..
  85. Schoenlein P, Gallman L, Winkler M, Ely B. Nucleotide sequence of the Caulobacter crescentus flaF and flbT genes and an analysis of codon usage in organisms with G + C-rich genomes. Gene. 1990;93:17-25 pubmed
    ..Furthermore, comparison to the codon usage of other organisms with G + C-rich genomes indicated a strong preference for the same codons preferred by C. crescentus. ..
  86. Ross C, Winkler M. Structure of the Caulobacter crescentus trpFBA operon. J Bacteriol. 1988;170:757-68 pubmed
    ..crescentus and other bacteria. Taken together, these results are relevant to the analysis of gene expression in C. crescentus and the study of trp gene structure and regulation. ..
  87. Mullin D, Minnich S, Chen L, Newton A. A set of positively regulated flagellar gene promoters in Caulobacter crescentus with sequence homology to the nif gene promoters of Klebsiella pneumoniae. J Mol Biol. 1987;195:939-43 pubmed
    ..We speculate that the conserved sequence elements mapping at -13, -24 and -100 are cis-acting regulatory elements required for the transcription and periodic regulation of these fla genes in the C. crescentus cell cycle...
  88. Minnich S, Newton A. Promoter mapping and cell cycle regulation of flagellin gene transcription in Caulobacter crescentus. Proc Natl Acad Sci U S A. 1987;84:1142-6 pubmed
    ..This result supports a model in which the timing of fla gene transcription in the C. crescentus cell cycle is determined in part by a cascade of trans-acting regulatory gene products...
  89. Steinman H. Copper-zinc superoxide dismutase from Caulobacter crescentus CB15. A novel bacteriocuprein form of the enzyme. J Biol Chem. 1982;257:10283-93 pubmed
    ..has been discovered, purified, and characterized from the free living, non-symbiotic bacterium, Caulobacter crescentus CB15. In its native molecular weight, homodimeric subunit structure, specific activity, and metal content, ..
  90. Malakooti J, Wang S, Ely B. A consensus promoter sequence for Caulobacter crescentus genes involved in biosynthetic and housekeeping functions. J Bacteriol. 1995;177:4372-6 pubmed
  91. Malakooti J, Ely B. Identification and characterization of the ilvR gene encoding a LysR-type regulator of Caulobacter crescentus. J Bacteriol. 1994;176:1275-81 pubmed
    ..Amino acid sequence comparison revealed that the IlvR protein is a member of the LysR family of transcriptional regulators. ..
  92. Marques M, Gomes S, Gober J. A gene coding for a putative sigma 54 activator is developmentally regulated in Caulobacter crescentus. J Bacteriol. 1997;179:5502-10 pubmed
    ..These results suggest that the TacA protein could mediate the effect of sigma54 on a different pathway in C. crescentus. ..