Experts and Doctors on ribosomes in Milwaukee, Wisconsin, United States

Summary

Locale: Milwaukee, Wisconsin, United States
Topic: ribosomes

Top Publications

  1. Kovalchuke O, Kambampati R, Pladies E, Chakraburtty K. Competition and cooperation amongst yeast elongation factors. Eur J Biochem. 1998;258:986-93 pubmed
    ..These results strongly suggest that the stimulatory effect of EF-3 on the ternary complex binding to yeast ribosomes involves a direct interaction between EF-1 alpha and EF-3. ..
  2. Chakraburtty K. Translational regulation by ABC systems. Res Microbiol. 2001;152:391-9 pubmed
    ..The reaction requires ATP hydrolysis. EF-3 contains two ATP binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions...
  3. Kamath A, Chakraburtty K. Role of yeast elongation factor 3 in the elongation cycle. J Biol Chem. 1989;264:15423-8 pubmed
    ..and Kamath, A. (1988) Int. J. Biochem. 20, 581-590). However, we failed to demonstrate the effect of EF-3 in binding aa-tRNA to such a heterologous combination of the ribosomal subunits. ..
  4. Lerch Gaggl A, Haque J, Li J, Ning G, Traktman P, Duncan S. Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. J Biol Chem. 2002;277:45347-55 pubmed
    ..We propose that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest. ..
  5. Jia L, Dienhart M, Schramp M, McCauley M, Hell K, Stuart R. Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1. EMBO J. 2003;22:6438-47 pubmed
    ..Mrp20 is homologous to L23, a subunit located next to the peptide exit tunnel of the ribosome. We propose that the interaction of Oxa1 with the ribosome serves to enhance a coupling of translation and membrane insertion events. ..
  6. Urbinati C, Gonsalvez G, Aris J, Long R. Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit. Mol Genet Genomics. 2006;276:369-77 pubmed
  7. Meng H, Liang H, Wong Riley M. Quantitative immuno-electron microscopic analysis of depolarization-induced expression of PGC-1alpha in cultured rat visual cortical neurons. Brain Res. 2007;1175:10-6 pubmed
    ..PGC-1alpha level in neurons is, therefore, tightly regulated by neuronal activity. ..
  8. Jia L, Kaur J, Stuart R. Mapping of the Saccharomyces cerevisiae Oxa1-mitochondrial ribosome interface and identification of MrpL40, a ribosomal protein in close proximity to Oxa1 and critical for oxidative phosphorylation complex assembly. Eukaryot Cell. 2009;8:1792-802 pubmed publisher
  9. Kaur J, Stuart R. Truncation of the Mrp20 protein reveals new ribosome-assembly subcomplex in mitochondria. EMBO Rep. 2011;12:950-5 pubmed publisher
    ..Finally, data supporting the idea that the inner mitochondrial membrane acts as a platform for the ribosome assembly process are discussed. ..

Detail Information

Publications9

  1. Kovalchuke O, Kambampati R, Pladies E, Chakraburtty K. Competition and cooperation amongst yeast elongation factors. Eur J Biochem. 1998;258:986-93 pubmed
    ..These results strongly suggest that the stimulatory effect of EF-3 on the ternary complex binding to yeast ribosomes involves a direct interaction between EF-1 alpha and EF-3. ..
  2. Chakraburtty K. Translational regulation by ABC systems. Res Microbiol. 2001;152:391-9 pubmed
    ..The reaction requires ATP hydrolysis. EF-3 contains two ATP binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions...
  3. Kamath A, Chakraburtty K. Role of yeast elongation factor 3 in the elongation cycle. J Biol Chem. 1989;264:15423-8 pubmed
    ..and Kamath, A. (1988) Int. J. Biochem. 20, 581-590). However, we failed to demonstrate the effect of EF-3 in binding aa-tRNA to such a heterologous combination of the ribosomal subunits. ..
  4. Lerch Gaggl A, Haque J, Li J, Ning G, Traktman P, Duncan S. Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. J Biol Chem. 2002;277:45347-55 pubmed
    ..We propose that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest. ..
  5. Jia L, Dienhart M, Schramp M, McCauley M, Hell K, Stuart R. Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1. EMBO J. 2003;22:6438-47 pubmed
    ..Mrp20 is homologous to L23, a subunit located next to the peptide exit tunnel of the ribosome. We propose that the interaction of Oxa1 with the ribosome serves to enhance a coupling of translation and membrane insertion events. ..
  6. Urbinati C, Gonsalvez G, Aris J, Long R. Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit. Mol Genet Genomics. 2006;276:369-77 pubmed
  7. Meng H, Liang H, Wong Riley M. Quantitative immuno-electron microscopic analysis of depolarization-induced expression of PGC-1alpha in cultured rat visual cortical neurons. Brain Res. 2007;1175:10-6 pubmed
    ..PGC-1alpha level in neurons is, therefore, tightly regulated by neuronal activity. ..
  8. Jia L, Kaur J, Stuart R. Mapping of the Saccharomyces cerevisiae Oxa1-mitochondrial ribosome interface and identification of MrpL40, a ribosomal protein in close proximity to Oxa1 and critical for oxidative phosphorylation complex assembly. Eukaryot Cell. 2009;8:1792-802 pubmed publisher
  9. Kaur J, Stuart R. Truncation of the Mrp20 protein reveals new ribosome-assembly subcomplex in mitochondria. EMBO Rep. 2011;12:950-5 pubmed publisher
    ..Finally, data supporting the idea that the inner mitochondrial membrane acts as a platform for the ribosome assembly process are discussed. ..