Experts and Doctors on kinesin in Milwaukee, Wisconsin, United States

Summary

Locale: Milwaukee, Wisconsin, United States
Topic: kinesin

Top Publications

  1. Baker S, Freeman K, Luby Phelps K, Pazour G, Besharse J. IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J Biol Chem. 2003;278:34211-8 pubmed
    ..Our data indicate that all four mammalian IFT proteins are part of a highly conserved complex in multiple ciliated cell types. Furthermore, IFT20 appears to bridge kinesin II with the IFT complex. ..
  2. Insinna C, Pathak N, Perkins B, Drummond I, Besharse J. The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. Dev Biol. 2008;316:160-70 pubmed publisher
    ..Our analysis shows that Kif17 is essential for photoreceptor OS development, and suggests that Kif17 plays a cell type specific role in vertebrate ciliogenesis. ..
  3. Dhar S, Wong Riley M. The kinesin superfamily protein KIF17 is regulated by the same transcription factor (NRF-1) as its cargo NR2B in neurons. Biochim Biophys Acta. 2011;1813:403-11 pubmed publisher
  4. Mavlyutov T, Cai Y, Ferreira P. Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. Traffic. 2002;3:630-40 pubmed
    ..The implications of these findings in protein kinesis and pathogenesis of degenerative neuropathies are discussed. ..
  5. Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse J. Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev Dyn. 2009;238:2211-22 pubmed publisher
    ..In contrast, dominant-negative KIF17 has no obvious effect on inner segment or synaptic organization but has an immediate impact on outer segment assembly. ..
  6. Bader J, Kusik B, Besharse J. Analysis of KIF17 distal tip trafficking in zebrafish cone photoreceptors. Vision Res. 2012;75:37-43 pubmed publisher
    ..In some cases KIF17-GFP is shed with the OS tip as part of the disc shedding process. We have also found that KIF17-GFP moves within the OS at rates consistent with those observed for IFT and other kinesins. ..
  7. Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J. Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol. 2017;425:176-190 pubmed publisher
    ..In conclusion, we show that both osm-3/kif17 and cos2/kif7 have comparable outer segment developmental delays, although through independent mechanisms. ..

Detail Information

Publications7

  1. Baker S, Freeman K, Luby Phelps K, Pazour G, Besharse J. IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J Biol Chem. 2003;278:34211-8 pubmed
    ..Our data indicate that all four mammalian IFT proteins are part of a highly conserved complex in multiple ciliated cell types. Furthermore, IFT20 appears to bridge kinesin II with the IFT complex. ..
  2. Insinna C, Pathak N, Perkins B, Drummond I, Besharse J. The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. Dev Biol. 2008;316:160-70 pubmed publisher
    ..Our analysis shows that Kif17 is essential for photoreceptor OS development, and suggests that Kif17 plays a cell type specific role in vertebrate ciliogenesis. ..
  3. Dhar S, Wong Riley M. The kinesin superfamily protein KIF17 is regulated by the same transcription factor (NRF-1) as its cargo NR2B in neurons. Biochim Biophys Acta. 2011;1813:403-11 pubmed publisher
  4. Mavlyutov T, Cai Y, Ferreira P. Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. Traffic. 2002;3:630-40 pubmed
    ..The implications of these findings in protein kinesis and pathogenesis of degenerative neuropathies are discussed. ..
  5. Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse J. Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev Dyn. 2009;238:2211-22 pubmed publisher
    ..In contrast, dominant-negative KIF17 has no obvious effect on inner segment or synaptic organization but has an immediate impact on outer segment assembly. ..
  6. Bader J, Kusik B, Besharse J. Analysis of KIF17 distal tip trafficking in zebrafish cone photoreceptors. Vision Res. 2012;75:37-43 pubmed publisher
    ..In some cases KIF17-GFP is shed with the OS tip as part of the disc shedding process. We have also found that KIF17-GFP moves within the OS at rates consistent with those observed for IFT and other kinesins. ..
  7. Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J. Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol. 2017;425:176-190 pubmed publisher
    ..In conclusion, we show that both osm-3/kif17 and cos2/kif7 have comparable outer segment developmental delays, although through independent mechanisms. ..