Experts and Doctors on mice in Seattle, Washington, United States

Summary

Locale: Seattle, Washington, United States
Topic: mice

Top Publications

  1. Polyak S, Tang N, Wambach M, Barber G, Katze M. The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. J Biol Chem. 1996;271:1702-7 pubmed
    ..These data, taken together, demonstrate that P58 inhibits PKR through a direct interaction, which is likely independent of the binding of double-stranded RNA to the protein kinase. ..
  2. Andress D. IGF-binding protein-5 stimulates osteoblast activity and bone accretion in ovariectomized mice. Am J Physiol Endocrinol Metab. 2001;281:E283-8 pubmed
    ..The finding that IGFBP-5-(1--169) is bioactive in vivo indicates that the carboxy-terminal portion is not required for this bone anabolic effect...
  3. Disteche C. Escape from X inactivation in human and mouse. Trends Genet. 1995;11:17-22 pubmed
    ..Questions about the mechanisms of 'escape' are relevant to the understanding of gene regulation by X inactivation. ..
  4. Dorsky R, Moon R, Raible D. Control of neural crest cell fate by the Wnt signalling pathway. Nature. 1998;396:370-3 pubmed
    ..We conclude that endogenous Wnt signalling normally promotes pigment-cell formation by medial crest cells and thereby contributes to the diversity of neural crest cell fates. ..
  5. Dooley J, Erickson M, Farr A. An organized medullary epithelial structure in the normal thymus expresses molecules of respiratory epithelium and resembles the epithelial thymic rudiment of nude mice. J Immunol. 2005;175:4331-7 pubmed
    ..Finally, epitopes that define thymic epithelial heterogeneity are reciprocally expressed by respiratory epithelium, which raises interesting questions regarding the developmental relationship of different endodermal derivatives. ..
  6. Snyder J, Washington I, Birkland T, Chang M, Frevert C. Correlation of Versican Expression, Accumulation, and Degradation during Embryonic Development by Quantitative Immunohistochemistry. J Histochem Cytochem. 2015;63:952-67 pubmed publisher
    ..These data suggest that versican plays an important role in fundamental, overlapping cellular processes in lung development and infection. ..
  7. Lozeman F, Litchfield D, Piening C, Takio K, Walsh K, Krebs E. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. Biochemistry. 1990;29:8436-47 pubmed
    ..1 encoded the alpha' subunit. These studies show that there are two distinct catalytic subunits for casein kinase II (alpha and alpha') and that the sequence of these subunits is largely conserved between the bovine and the human. ..
  8. Collins M, Bornstein P. SP1-binding elements, within the common metaxin-thrombospondin 3 intergenic region, participate in the regulation of the metaxin gene. Nucleic Acids Res. 1996;24:3661-9 pubmed
    ..Thus, despite the potential for common regulatory mechanisms, the available evidence indicates that the Mtx minimal promoter does not significantly affect Thbs3 gene expression. ..
  9. Oshima J. Comparative aspects of the Werner syndrome gene. In Vivo. 2000;14:165-72 pubmed
    ..This review focuses on the comparative aspects of WRN, including differential gene action within humans and the potential differences between species, particularly the mouse and human. ..

More Information

Publications337 found, 100 shown here

  1. Sultana R, Adler D, Edelhoff S, Carrel L, Lee K, Chapman V, et al. The mouse Sb1.8 gene located at the distal end of the X chromosome is subject to X inactivation. Hum Mol Genet. 1995;4:257-63 pubmed
    ..spretus X chromosome is inactivated. The Sb1.8 gene is a new member of a group of genes that escape X inactivation in human, but are inactivated in mouse. ..
  2. Adler D, Quaderi N, Brown S, Chapman V, Moore J, Tate P, et al. The X-linked methylated DNA binding protein, Mecp2, is subject to X inactivation in the mouse. Mamm Genome. 1995;6:491-2 pubmed
    ..Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse. ..
  3. Soderling J, Reed M, Corsa A, Sage E. Cloning and expression of murine SC1, a gene product homologous to SPARC. J Histochem Cytochem. 1997;45:823-35 pubmed
  4. Roach J, Wang K, Gan L, Hood L. The molecular evolution of the vertebrate trypsinogens. J Mol Evol. 1997;45:640-52 pubmed
    ..We employ this phylogeny as a vehicle for speculation on the evolution of the trypsinogen gene family as well as the general modes of evolution of multigene families. Unique attributes of the lamprey and tunicate trypsinogens are noted. ..
  5. Hohmann J, Jureus A, Teklemichael D, Matsumoto A, Clifton D, Steiner R. Distribution and regulation of galanin receptor 1 messenger RNA in the forebrain of wild type and galanin-transgenic mice. Neuroscience. 2003;117:105-17 pubmed
    ..However, the lack of significant changes in galanin receptor 1 messenger RNA in galanin-knockout mice suggests that developmentally programmed levels of receptor expression are maintained even in the complete absence of ligand. ..
  6. Richardson A, Fischer K, Speakman J, De Cabo R, Mitchell S, Peterson C, et al. Measures of Healthspan as Indices of Aging in Mice-A Recommendation. J Gerontol A Biol Sci Med Sci. 2016;71:427-30 pubmed publisher
    ..Finally, we strongly recommend that functional measurements be performed in both males and females so that sex differences in the rate of functional decline in different domains are taken into consideration. ..
  7. Linnemeyer P, Hamilton M. A monoclonal antibody, 4H12, recognizes a surface antigen found on granulated metrial gland cells in the murine decidua. J Reprod Immunol. 1990;17:279-94 pubmed
    ..This MAb should greatly facilitate the further analysis of the life history and function of GMG cells during pregnancy...
  8. Gilladoga A, Edelhoff S, Blackwood E, Eisenman R, Disteche C. Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization. Oncogene. 1992;7:1249-51 pubmed
    ..The mapping results also confirm a region of homology between human chromosome 14q22-24 and mouse chromosome 12 region D. ..
  9. Schorderet D, Gartler S. Analysis of CpG suppression in methylated and nonmethylated species. Proc Natl Acad Sci U S A. 1992;89:957-61 pubmed
    ..We speculate that the excess of CpGs at position III-I in nonmethylated forms may be related to a requirement for minimal thermal stability of the DNA. ..
  10. Chance P, Cavalier L, Satran D, Pellegrino J, Koenig M, Dobyns W. Clinical nosologic and genetic aspects of Joubert and related syndromes. J Child Neurol. 1999;14:660-6; discussion 669-72 pubmed
    ..This observation, along with those from clinical studies, provides further evidence that Joubert and related syndromes are genetically heterogeneous. ..
  11. Leprince C, Draves K, Geahlen R, Ledbetter J, Clark E. CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci U S A. 1993;90:3236-40 pubmed
  12. Schultz S, Zhang M, Champoux J. Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus. J Virol. 2003;77:5275-85 pubmed
    ..These data suggest a model in which efficient initiation of plus-strand synthesis requires the generation of a gap immediately following the plus-strand primer 3' terminus...
  13. Lai Y, Altemeier W, Vandree J, Piliponsky A, Johnson B, Appel C, et al. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. J Allergy Clin Immunol. 2014;133:1448-55 pubmed publisher
    ..Mast cell infiltration of the epithelium is a critical determinant of indirect airway hyperresponsiveness, and the airway epithelium might serve as an important regulator of the development and function of this mast cell population. ..
  14. Farr A, Nelson A, Truex J, Hosier S. Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium. J Histochem Cytochem. 1991;39:645-53 pubmed
    ..This MAb also exhibited reactivity with gut and epidermal epithelium and some tubular epithelium in the kidney, but did not react with epithelial parenchymal cells of the liver. ..
  15. Clegg C, Cadd G, McKnight G. Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1988;85:3703-7 pubmed
    ..RI beta protein produced in 3T3 cells was shown to be functional by its ability to form a cAMP-dependent holoenzyme with the catalytic subunit. ..
  16. Gross J, Appleby M, Chien S, Nada S, Bartelmez S, Okada M, et al. Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase. J Exp Med. 1995;181:463-73 pubmed
    ..We conclude that p50csk regulates normal lymphocyte differentiation, but that it almost certainly does so by acting on targets other than p56lck and p59fyn. ..
  17. Snow A, Sekiguchi R, Nochlin D, Fraser P, Kimata K, Mizutani A, et al. An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain. Neuron. 1994;12:219-34 pubmed
  18. Tsuchiya K, Mulcahy R, Reid L, Disteche C, Kavanagh T. Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 1995;30:630-2 pubmed
  19. Street V, Tempel B. Physical mapping of potassium channel gene clusters on mouse chromosomes three and six. Genomics. 1997;44:110-7 pubmed
    ..These detailed physical maps of both K channel gene clusters provide additional support for the idea of an ancient genome tetraploidization event. ..
  20. Quigley J, Burns C, Anderson M, Lynch E, Sabo K, Overbaugh J, et al. Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia. Blood. 2000;95:1093-9 pubmed
    ..By radiation hybrid mapping, the human gene was localized to a 0.5-centiMorgan region on the long arm of chromosome 1 at q31.3...
  21. Pratt K, Qian J, Ellaban E, Okita D, Diethelm Okita B, Conti Fine B, et al. Immunodominant T-cell epitopes in the factor VIII C2 domain are located within an inhibitory antibody binding site. Thromb Haemost. 2004;92:522-8 pubmed
    ..These findings suggest that a major T-cell epitope in the C2 domain recognized by hemophilic mice is located within the same region that binds to inhibitors, vWF, and activated membranes. ..
  22. Deng X, Hiatt J, Nguyen D, Ercan S, Sturgill D, Hillier L, et al. Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster. Nat Genet. 2011;43:1179-85 pubmed publisher
    ..elegans and Drosophila. Our analyses, which take into account the skewed gene content of the X chromosome, support the hypothesis of upregulation of expressed X-linked genes to balance expression of the genome. ..
  23. Westenbroek R, Noebels J, Catterall W. Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain. J Neurosci. 1992;12:2259-67 pubmed
    ..The selective increase in the number of type II channels in hypomyelinated fiber tracts may contribute to the hyperexcitable phenotype of the shiverer mouse. ..
  24. Nelson A, Dunn R, Peach R, Aruffo A, Farr A. The murine homolog of human Ep-CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells. Eur J Immunol. 1996;26:401-8 pubmed
  25. Zhang Y, Rogers K, Lewis D. Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J Exp Med. 1996;184:1507-12 pubmed
    ..These results indicate that the NK1.1+ alpha/beta+ T cell population, as well as other beta 2m-dependent populations, such as most peripheral alpha/beta+ CD8+ T cells, are dispensable for the Th2 pulmonary response to protein allergens. ..
  26. Han S, Ramesh N, Osborne W. Cloning and expression of the cDNA encoding rat granulocyte colony-stimulating factor. Gene. 1996;175:101-4 pubmed
    ..A retrovirus encoding the rat G-CSF cDNA synthesized bioactive G-CSF from transduced vascular smooth muscle cells. ..
  27. Nakagawa T, Brissette W, Lira P, Griffiths R, Petrushova N, Stock J, et al. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity. 1999;10:207-17 pubmed
    ..CatS-deficient mice showed diminished susceptibility to collagen-induced arthritis, suggesting a potential therapeutic target for regulation of immune responsiveness. ..
  28. Rajan I, Gestblom C, Kapur R. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatr Dev Pathol. 2001;4:446-53 pubmed
    ..We find that expression of the RET(Men2B) transgene in enteric neural progenitors, after they colonize the gut, does not prevent intestinal aganglionosis associated with gdnf or gfr alpha-1 deficiency. ..
  29. Zou J, Ichikawa H, Blackburn M, Hu H, Zielinska Kwiatkowska A, Mei Q, et al. The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts. Mol Cell Biol. 2005;25:6235-46 pubmed
    ..Taken together, these results suggest that the oncogenic TLS-ERG fusion protein transforms hematopoietic cells and fibroblasts via different pathways. ..
  30. Foster B, Nagatomo K, Bamashmous S, Tompkins K, Fong H, Dunn D, et al. The progressive ankylosis protein regulates cementum apposition and extracellular matrix composition. Cells Tissues Organs. 2011;194:382-405 pubmed publisher
    ..Studies here aimed to define the role of ANK in root and cementum by analyzing tooth development in Ank knock-out (KO) mice versus wild type...
  31. Ansari M, Shope R, Malik S. Evaluation of vero cell lysate antigen for the ELISA of flaviviruses. J Clin Lab Anal. 1993;7:230-7 pubmed
    ..The ELISA by the cell lysate antigen, within the limits of the experiments done, was found to be a good replacement for the ELISA by the standard method...
  32. Tonge R, Kelly E, Bruschi S, Kalhorn T, Eaton D, Nebert D, et al. Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice. Toxicol Appl Pharmacol. 1998;153:102-8 pubmed
    ..The cumulative data suggest that Cyp1a2 doses not play a significant role in APAP hepatotoxicity in these mice. ..
  33. Disteche C, Brannan C, Larsen A, Adler D, Schorderet D, Gearing D, et al. The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse. Nat Genet. 1992;1:333-6 pubmed
  34. Appleby M, Gross J, Cooke M, Levin S, Qian X, Perlmutter R. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell. 1992;70:751-63 pubmed
    ..These data confirm that p59fynT plays a pivotal role in TCR signal transduction and demonstrate that additional developmentally regulated signaling components also contribute to TCR-induced lymphocyte activation. ..
  35. Zhou Q, Palmiter R. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell. 1995;83:1197-209 pubmed
    ..With continued administration of L-DOPA, nearly normal growth was achieved. These studies indicate that DA is essential for movement and feeding, but is not required for the development of neural circuits that control these behaviors. ..
  36. Armstrong L, Saenz A, Bornstein P. Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane. J Cell Biochem. 1999;74:11-22 pubmed
  37. Hayashi F, Smith K, Ozinsky A, Hawn T, Yi E, Goodlett D, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001;410:1099-103 pubmed
    ..Our data suggest that TLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens. ..
  38. Pace J, Corrado M, Missero C, Byers P. Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1. Matrix Biol. 2003;22:3-14 pubmed
    ..Study of this collagen should yield insights into normal chondrogenesis, and provide clues to the pathogenesis of some chondrodysplasias and disorders of other tissues in which this gene is expressed. ..
  39. Raines E, Lane T, Iruela Arispe M, Ross R, Sage E. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc Natl Acad Sci U S A. 1992;89:1281-5 pubmed
    ..We suggest that the coordinate expression of SPARC and PDGF-B-containing dimers following vascular injury may regulate the activity of specific dimeric forms of PDGF in vivo. ..
  40. Dillon S, Jameson S, Fink P. V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition. J Immunol. 1994;152:1790-801 pubmed
    ..These experiments support the notion that a discrete portion of the responding TCR can heavily influence but not necessarily be solely sufficient for the recognition of a peptide Ag presented in the cleft of an MHC-encoded molecule. ..
  41. Chen W, Qin H, Chesebro B, Cheever M. Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. J Virol. 1996;70:7773-82 pubmed
    ..Thus, the CTL epitope of FBL-3 is localized to the transmembrane anchor domain of the nonstructural Gag polyprotein and is shared by leukemia/lymphoma cell lines induced by Friend, Moloney, and Rauscher MuLV...
  42. Kovats S, Grubin C, Eastman S, deRoos P, Dongre A, van Kaer L, et al. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med. 1998;187:245-51 pubmed
    ..These findings are consistent with the idea that H-2M functions as a chaperone in the peptide loading of class II molecules in vivo. ..
  43. Vanasse G, Halbrook J, Thomas S, Burgess A, Hoekstra M, Disteche C, et al. Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase. J Clin Invest. 1999;103:1669-75 pubmed
  44. Hankenson K, Bain S, Kyriakides T, Smith E, Goldstein S, Bornstein P. Increased marrow-derived osteoprogenitor cells and endosteal bone formation in mice lacking thrombospondin 2. J Bone Miner Res. 2000;15:851-62 pubmed
    ..We conclude that TSP2 regulates the proliferation of osteoblast progenitors, directly or indirectly, and that in its absence endosteal bone formation is increased. ..
  45. Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, et al. Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circ Res. 2017;121:1182-1191 pubmed publisher
    ..Increased γ2-AMPK activity is required to protect against ischemia/reperfusion injury. Our study reveals an isoform-specific function of γ2-AMPK in modulating ribosome biosynthesis, cell survival, and cardioprotection. ..
  46. Cadd G, Uhler M, McKnight G. Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides. J Biol Chem. 1990;265:19502-6 pubmed
    ..These results suggest that amino acid differences in the pseudosubstrate site may account for some, but not all, of the increased sensitivity to cyclic nucleotides exhibited by RI beta. ..
  47. Barber G, Edelhoff S, Katze M, Disteche C. Chromosomal assignment of the interferon-inducible double-stranded RNA-dependent protein kinase (PRKR) to human chromosome 2p21-p22 and mouse chromosome 17 E2. Genomics. 1993;16:765-7 pubmed
    ..Finally, our results define a new region of conservation between the distal part of the short arm of chromosome 2 (band p21) and band E2 of mouse chromosome 17. ..
  48. Ostrowski J, Van Seuningen I, Seger R, Rauch C, Sleath P, McMullen B, et al. Purification, cloning, and expression of a murine phosphoprotein that binds the kappa B motif in vitro identifies it as the homolog of the human heterogeneous nuclear ribonucleoprotein K protein. Description of a novel DNA-dependent phosphorylation p. J Biol Chem. 1994;269:17626-34 pubmed
    ..We also demonstrate that the in vitro phosphorylation of the natural and the recombinant K proteins by the associated kinase is stimulated by the kappa B motif. ..
  49. Pendergrass W, Saulewicz A, Hanaoka F, Norwood T. Murine temperature-sensitive DNA polymerase alpha mutant displays a diminished capacity to stimulate DNA synthesis in senescent human fibroblast nuclei in heterokaryons at the nonpermissive condition. J Cell Physiol. 1994;158:270-6 pubmed
  50. Koontz M, Hendrickson A. Comparison of immunolocalization patterns for the synaptic vesicle proteins p65 and synapsin I in macaque monkey retina. Synapse. 1993;14:268-82 pubmed
  51. Levin S, Anderson S, Forbush K, Perlmutter R. A dominant-negative transgene defines a role for p56lck in thymopoiesis. EMBO J. 1993;12:1671-80 pubmed
    ..These results suggest that p56lck normally regulates T cell production by metering the replicative potential of immature thymoblasts. ..
  52. Lee I, Westaway D, Smit A, Wang K, Seto J, Chen L, et al. Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res. 1998;8:1022-37 pubmed
    ..2-kb mariner transposable element. (4) We identified sequences in noncoding DNA that are conserved between the three species and may represent biologically functional sites. ..
  53. Rufibach L, Duncan S, Battle M, Deeb S. Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. J Lipid Res. 2006;47:1463-77 pubmed
    ..The overall effect these transcription factors have on HL expression will ultimately depend on the interplay between these various factors and their relative intracellular concentrations. ..
  54. Deyerle K, Sims J, Dower S, Bothwell M. Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes. J Immunol. 1992;149:1657-65 pubmed
    ..The distributional segregation of the receptor types and the expression of IL-1R in normal nonlymphoid tissues has broad implications for the role of IL-1 in homeostatic physiology. ..
  55. Gronwald R, Grant F, Haldeman B, Hart C, O Hara P, Hagen F, et al. Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. Proc Natl Acad Sci U S A. 1988;85:3435-9 pubmed
    ..This observation is consistent with the existence of more than one PDGF receptor class. ..
  56. Kaushansky K, Broudy V, Lin N, Jorgensen M, McCarty J, Fox N, et al. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci U S A. 1995;92:3234-8 pubmed
    ..Thus, our results strongly suggest that Tpo is the primary regulator of MK development and platelet production. ..
  57. Schiemann W, Graves L, Baumann H, Morella K, Gearing D, Nielsen M, et al. Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation. Proc Natl Acad Sci U S A. 1995;92:5361-5 pubmed
    ..Thus, our results identify the human LIFR as a substrate for MAPK and suggest a mechanism of heterologous receptor regulation of LIFR signaling occurring at Ser-1044. ..
  58. Marsh D, Hollopeter G, Kafer K, Palmiter R. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med. 1998;4:718-21 pubmed
    ..These results demonstrate that the Y5R contributes to feeding induced by centrally administered NPY and its analogs, but is not a critical physiological feeding receptor in mice. ..
  59. Konrad Martin D, Norton S, Mascher K, Tempel B. Effects of PMCA2 mutation on DPOAE amplitudes and latencies in deafwaddler mice. Hear Res. 2001;151:205-220 pubmed
    ..Similar to the effects of furosemide, the mutation reduced DPOAEs for low-level stimuli; in contrast to furosemide, the mutation altered DPOAEs elicited by high levels. ..
  60. Johnson A, Becker K, Zager R. Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury. Am J Physiol Renal Physiol. 2010;299:F426-35 pubmed publisher
    ..The clinical implication(s) of the latter, vis a vis the treatment of Fe deficiency in renal disease patients, remains to be defined. ..
  61. Kaushansky K, Shoemaker S, Broudy V, Lin N, Matous J, Alderman E, et al. Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3. J Clin Invest. 1992;90:1879-88 pubmed
  62. Sarthy P, Fu M, Huang J. Developmental expression of the glial fibrillary acidic protein (GFAP) gene in the mouse retina. Cell Mol Neurobiol. 1991;11:623-37 pubmed
    ..7. Finally, we did not find either GFAP or GFAP mRNA in retinal cells other than astrocytes during normal development. ..
  63. Turker M, Stambrook P, Tischfield J, Smith A, Martin G. Allelic variation linked to adenine phosphoribosyltransferase locus in mouse teratocarcinoma cell line and feral-derived mouse strains. Somat Cell Mol Genet. 1989;15:159-66 pubmed
    ..A third, distinct APRT allele was found in a Mus spretus feral-derived mouse. Exploiting the differences between the two APRT alleles in the P-19 cell line, we have demonstrated their sequential loss in APRT-deficient clones. ..
  64. Wildin R, Wang H, Forbush K, Perlmutter R. Functional dissection of the murine lck distal promoter. J Immunol. 1995;155:1286-95 pubmed
    ..In addition, these regulatory regions should assist in defining T cell-specific trans-acting factors. ..
  65. Brandon E, Gerhold K, Qi M, McKnight G, Idzerda R. Derivation of novel embryonic stem cell lines and targeting of cyclic AMP-dependent protein kinase genes. Recent Prog Horm Res. 1995;50:403-8 pubmed
  66. Zambrowicz B, Harendza C, Zimmermann J, Brinster R, Palmiter R. Analysis of the mouse protamine 1 promoter in transgenic mice. Proc Natl Acad Sci U S A. 1993;90:5071-5 pubmed
    ..These results will facilitate the isolation and characterization of transcription factors essential for post-meiotic gene expression. ..
  67. Moser M, Oshima J, Monnat R. WRN mutations in Werner syndrome. Hum Mutat. 1999;13:271-9 pubmed
  68. Komada M, McLean D, Griswold M, Russell L, Soriano P. E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Genes Dev. 2000;14:1332-42 pubmed
  69. Hull R, Andrikopoulos S, Verchere C, Vidal J, Wang F, Cnop M, et al. Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid. Diabetes. 2003;52:372-9 pubmed
  70. Campbell L, Kuo C. Chlamydia pneumoniae and atherosclerosis. Semin Respir Infect. 2003;18:48-54 pubmed
    ..pneumoniae plays a role in atherogenesis. This review summarizes in vitro studies, results in animal models of C. pneumoniae infection and atherogenesis, and human intervention studies that provide some support of a mechanistic role. ..
  71. El Abbadi M, Giachelli C. Mechanisms of vascular calcification. Adv Chronic Kidney Dis. 2007;14:54-66 pubmed
    ..This article reviews current mechanisms proposed for the regulation of vascular calcification and data supporting their potential contribution to this process in chronic kidney disease. ..
  72. Ieronimakis N, Hays A, Reyes M. Bone marrow-derived cells do not engraft into skeletal muscle microvasculature but promote angiogenesis after acute injury. Exp Hematol. 2012;40:238-249.e3 pubmed publisher
    ..Therefore, despite the absence of BM engraftment to regenerated skeletal muscle microvasculature, macrophages recruited after injury promote angiogenesis and, in turn, vascular regeneration...
  73. Raich N, Enver T, Nakamoto B, Josephson B, Papayannopoulou T, Stamatoyannopoulos G. Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science. 1990;250:1147-9 pubmed
  74. Schatteman G, Motley S, Effmann E, Bowen Pope D. Platelet-derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis. Teratology. 1995;51:351-66 pubmed
  75. Palczewski K, Subbaraya I, Gorczyca W, Helekar B, Ruiz C, Ohguro H, et al. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein. Neuron. 1994;13:395-404 pubmed
  76. Palmiter R, Findley S. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 1995;14:639-49 pubmed
    ..We propose that ZnT-1 transports zinc out of cells and that its absence accounts for the increased sensitivity of mutant cells to zinc toxicity. ..
  77. Palmiter R, Cole T, Quaife C, Findley S. ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A. 1996;93:14934-9 pubmed
    ..We propose that ZnT-3 facilitates the accumulation of zinc in synaptic vesicles. ..
  78. Yablonka Reuveni Z, Christ B, Benson J. Transitions in cell organization and in expression of contractile and extracellular matrix proteins during development of chicken aortic smooth muscle: evidence for a complex spatial and temporal differentiation program. Anat Embryol (Berl). 1998;197:421-37 pubmed
    ..This detailed analysis of the ontogeny of chick aortic smooth muscle should provide a sound basis for future studies on the regulatory mechanisms underlying vascular smooth muscle development. ..
  79. Agah A, Kyriakides T, Lawler J, Bornstein P. The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice. Am J Pathol. 2002;161:831-9 pubmed
    ..These findings reflect distinct temporal and spatial expressions of TSP1 and TSP2 in the healing wound. ..
  80. Sopher B, Thomas P, LaFevre Bernt M, Holm I, Wilke S, Ware C, et al. Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron. 2004;41:687-99 pubmed
    ..Our results suggest that SBMA motor neuronopathy involves altered expression of VEGF, consistent with a role for VEGF as a neurotrophic/survival factor in motor neuron disease. ..
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