Genomes and Genes
Experts and Doctors on animals in Seattle, Washington, United States
Locale: Seattle, Washington, United States
Publications603 found, 100 shown here
- Hurley J, Spencer M, Niemi G. Rhodopsin phosphorylation and its role in photoreceptor function. Vision Res. 1998;38:1341-52 pubmed..We present one such method that uses mass spectrometry to quantitate rhodopsin phosphorylation in intact mouse retinas. ..
- Souders J, Doshier J, Polissar N, Hlastala M. Spatial distribution of venous gas emboli in the lungs. J Appl Physiol (1985). 1999;87:1937-47 pubmed..0 increase in relative baseline flow (P = 0.008). We conclude that the distribution of gaseous emboli is influenced by buoyancy and flow dynamics within the pulmonary vasculature...
- Mundinger T, Mei Q, Figlewicz D, Lernmark A, Taborsky G. Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy. Am J Physiol Endocrinol Metab. 2003;285:E1047-54 pubmed..We conclude that the early sympathetic islet neuropathy of BB D causes a functional defect of the sympathetic pathway to the alpha-cell that can, by itself, account for the impaired glucagon response to postganglionic SNS. ..
- McDonald M, Rettie A. Sequential metabolism and bioactivation of the hepatotoxin benzbromarone: formation of glutathione adducts from a catechol intermediate. Chem Res Toxicol. 2007;20:1833-42 pubmed..Isoform profiling with recombinant human P450s suggested that CYP2C9 is primarily responsible for the formation of this reactive quinone intermediate. ..
- Hassett C, Aicher L, Sidhu J, Omiecinski C. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum Mol Genet. 1994;3:421-8 pubmed..These data suggest that common human mEH amino acid polymorphisms may alter enzymatic function, possibly by modifying protein stability. ..
- Li Z, Kljavin I, Milam A. Rod photoreceptor neurite sprouting in retinitis pigmentosa. J Neurosci. 1995;15:5429-38 pubmed..The contributions of the rhodopsin-positive rod neurites and abnormal cone axons to the functional abnormalities observed in RP are unknown. ..
- Sultana R, Adler D, Edelhoff S, Carrel L, Lee K, Chapman V, et al. The mouse Sb1.8 gene located at the distal end of the X chromosome is subject to X inactivation. Hum Mol Genet. 1995;4:257-63 pubmed..spretus X chromosome is inactivated. The Sb1.8 gene is a new member of a group of genes that escape X inactivation in human, but are inactivated in mouse. ..
- Edelhoff S, Sweetser D, Disteche C. Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C. Genomics. 1995;25:309-11 pubmed..Based on its pattern of expression during development, NEP and Nep represent candidate genes for several MHC-linked developmental abnormalities in human and mouse. ..
- Miller A, Bonham L, Alfano J, Kiem H, Reynolds T, Wolgamot G. A novel murine retrovirus identified during testing for helper virus in human gene transfer trials. J Virol. 1996;70:1804-9 pubmed..MDEV does not belong to any of the known murine leukemia virus groups by interference analysis, and we have called the new group multitropic because of the wide range of cells from different species that MDEV can infect. ..
- Sohn S, Forbush K, Nguyen N, Witthuhn B, Nosaka T, Ihle J, et al. Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. J Immunol. 1998;160:2130-8 pubmed..Hence Jak3 exerts effects on mature peripheral T lymphocytes, as well as on thymocytes, resulting in the proper maintenance of circulating, quiescent cells. ..
- Huseby E, Ohlen C, Goverman J. Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice. J Immunol. 1999;163:1115-8 pubmed..This study is the first to show that the pool of self-reactive lymphocytes specific for MBP contain MHC class I-restricted T cells whose response is regulated in vivo by the induction of tolerance. ..
- Harmon J, Gleason C, Tanaka Y, Oseid E, Hunter Berger K, Robertson R. In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes. 1999;48:1995-2000 pubmed..These findings provide the first in vivo evidence that prevention of progressive hyperglycemia in a model of type 2 diabetes preserves insulin and PDX-1 gene expression. ..
- Herz A, Robertson M, Lynch J, Schmidt A, Rabin M, Sherbert C, et al. Viral dynamics of early HIV infection in neonatal macaques after oral exposure to HIV-2287: an animal model with implications for maternal-neonatal HIV transmission. J Med Primatol. 2002;31:29-39 pubmed..This animal model can now be used to study early viral replication in the presence and absence of anti-retroviral agents to help identify conditions to reduce vertical HIV transmission in human newborns. ..
- Marra C, Tantalo L, Maxwell C, Dougherty K, Wood B. Alternative cerebrospinal fluid tests to diagnose neurosyphilis in HIV-infected individuals. Neurology. 2004;63:85-8 pubmed..To identify alternatives to the CSF-Venereal Disease Research Laboratory (VDRL) test for the diagnosis of neurosyphilis in HIV-infected individuals...
- Hess C, Wang Z, Edwards S. Evolutionary genetics of Carpodacus mexicanus, a recently colonized host of a bacterial pathogen, Mycoplasma gallisepticum. Genetica. 2007;129:217-25 pubmed..These results will be further expanded using experimental studies as well as examination of evolution of the pathogen genome itself...
- Zhang J, Pippin J, Vaughan M, Krofft R, Taniguchi Y, Romagnani P, et al. Retinoids augment the expression of podocyte proteins by glomerular parietal epithelial cells in experimental glomerular disease. Nephron Exp Nephrol. 2012;121:e23-37 pubmed publisher..Thus, ATRA may provide a useful pharmacologic approach to decipher the mechanisms underlying the possible progenitor role of parietal epithelial cells. ..
- Hessell A, Malherbe D, Pissani F, McBurney S, Krebs S, Gomes M, et al. Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens. J Immunol. 2016;196:3064-78 pubmed publisher..These results demonstrate the potential for native Env derived from subjects at the time of neutralization broadening as effective HIV vaccine elements. ..
- Riddiford L, Ashburner M. Effects of juvenile hormone mimics on larval development and metamorphosis of Drosophila melanogaster. Gen Comp Endocrinol. 1991;82:172-83 pubmed..Thus, commitment for adult differentiation must occur early during this proliferative phase. ..
- Le Trong H, Parmelee D, Walsh K, Neurath H, Woodbury R. Amino acid sequence of rat mast cell protease I (chymase). Biochemistry. 1987;26:6988-94 pubmed..These results indicate that RMCP I and other chymotrypsin-like proteases of granulocyte and lymphocyte origin are more closely related to each other than to the pancreatic or plasma serine proteases. ..
- Grant R, Windsor S, Malinak C, Bartz C, Sabo A, Benveniste R, et al. Characterization of infectious type D retrovirus from baboons. Virology. 1995;207:292-6 pubmed..The homologies in the p27 segment were 91-94% and the homologies in the gp20 segment were 72-75%. ..
- Weiler K, Wakimoto B. Heterochromatin and gene expression in Drosophila. Annu Rev Genet. 1995;29:577-605 pubmed
- Kobarg J, Whitney G, Palmer D, Aruffo A, Bowen M. Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains. Eur J Immunol. 1997;27:2971-80 pubmed
- Stone J, Rubel E. Temporal, spatial, and morphologic features of hair cell regeneration in the avian basilar papilla. J Comp Neurol. 2000;417:1-16 pubmed..Examination of sister cells born at 3 days post-gentamicin reveals that there is equal likelihood that they will assume the hair cell or support cell fate (i.e., both asymmetric and symmetric differentiation occur). ..
- Laura R, Hurley J. The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2. Biochemistry. 1998;37:11264-71 pubmed..These findings suggest that GCAP-2 interacts constituitively with the KHDs of RetGC-1 and RetGC-2 and that cGMP synthesis is controlled by Ca2+-dependent conformational changes in the RetGC/GCAP complex. ..
- Overbaugh J, Rudensey L. Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaques. J Virol. 1992;66:5937-48 pubmed..Thus, common features of the SIV variants that evolve during progression to AIDS are motifs that potentially allow for structural and functional changes in the env protein as a result of carbohydrate addition. ..
- Ichinose A. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. Biochemistry. 1992;31:3113-8 pubmed..These data also make it possible to characterize the apo(a) and plasminogen genes in individuals by in vitro amplification. ..
- Giebelhaus D, Eib D, Moon R. Antisense RNA inhibits expression of membrane skeleton protein 4.1 during embryonic development of Xenopus. Cell. 1988;53:601-15 pubmed..These data suggest that reduced expression of a single membrane skeleton protein is sufficient to perturb normal cellular interactions of the retina. ..
- Costa L, Wu D, Olibet G, Murphy S. Formamidine pesticides and alpha 2-adrenoceptors: studies with amitraz and chlordimeform in rats and development of a radioreceptor binding assay. Neurotoxicol Teratol. 1989;11:405-11 pubmed
- Pichler R, Hugo C, Shankland S, Reed M, Bassuk J, Andoh T, et al. SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Kidney Int. 1996;50:1978-89 pubmed..In addition to its proposed role in extracellular matrix deposition. the antiproliferative properties of SPARC might contribute to the resolution of interstitial fibroblast proliferation in the PHN model. ..
- Martyn D, Freitag C, Chase P, Gordon A. Ca2+ and cross-bridge-induced changes in troponin C in skinned skeletal muscle fibers: effects of force inhibition. Biophys J. 1999;76:1480-93 pubmed..66 +/- 0.04 of pCa 4.0 control. These results indicate that cross-bridge binding in the rigor state alters sTnC structure, whereas cycling cross-bridges have little influence at either submaximum or maximum activating [Ca2+]. ..
- Cohen C, Plummer F, Mugo N, Maclean I, Shen C, Bukusi E, et al. Increased interleukin-10 in the the endocervical secretions of women with non-ulcerative sexually transmitted diseases: a mechanism for enhanced HIV-1 transmission?. AIDS. 1999;13:327-32 pubmed
- Maninger N, Sackett G, Ruppenthal G. Weaning, body weight, and postpartum amenorrhea duration in pigtailed macaques (Macaca nemestrina). Am J Primatol. 2000;52:81-91 pubmed..As the weaning age of the infant and the dam's weight increased, ovulation went from occurring after separation to occurring before separation. ..
- Verlinde C, Hannaert V, Blonski C, Willson M, Perie J, Fothergill Gilmore L, et al. Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resist Updat. 2001;4:50-65 pubmed..For some trypanosomatid enzymes, potent and selective inhibitors have already been developed that affect only the growth of cultured trypanosomatids, and not mammalian cells. ..
- Chuang P, Morefield S, Liu C, Chen S, Harlan J, Willerford D. Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1. Blood. 2002;99:3350-9 pubmed
- Noti M, Kim B, Siracusa M, Rak G, Kubo M, Moghaddam A, et al. Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis. J Allergy Clin Immunol. 2014;133:1390-9, 1399.e1-6 pubmed publisher..Epicutaneous sensitization on a disrupted skin barrier is associated with accumulation of TSLP-elicited basophils, which are necessary and sufficient to promote antigen-induced intestinal food allergy. ..
- Rider T, LeBoeuf R, Tso P, Jandacek R. The Use of Kits in the Analysis of Tissue Lipids Requires Validation. Lipids. 2016;51:497-504 pubmed publisher..We report here that lipids in liver and adipose tissues may be significantly underestimated by the use of some kits. We recommend that the use of kits for tissue analysis of lipids be validated for the specific analysis. ..
- Raines E, Lane T, Iruela Arispe M, Ross R, Sage E. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc Natl Acad Sci U S A. 1992;89:1281-5 pubmed..We suggest that the coordinate expression of SPARC and PDGF-B-containing dimers following vascular injury may regulate the activity of specific dimeric forms of PDGF in vivo. ..
- DeMarais A, Moon R. The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis. Dev Biol. 1992;153:337-46 pubmed..The presence of multiple homologs of armadillo in Xenopus embryos and the differences in their patterns of expression suggest distinct roles for these proteins in processes affected by cell adhesion. ..
- Fitzgerald B, Costa L. Modulation of M1 and M2 muscarinic receptor subtypes following repeated organophosphate exposure in rats. Toxicol Appl Pharmacol. 1992;117:122-5 pubmed..The results suggest that M1 and M2 receptor subtypes may be similarly regulated in response to subchronic exposure to organophosphates, but that recovery of receptor subtypes to control levels may be governed by distinct factors. ..
- Appleby M, Gross J, Cooke M, Levin S, Qian X, Perlmutter R. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell. 1992;70:751-63 pubmed..These data confirm that p59fynT plays a pivotal role in TCR signal transduction and demonstrate that additional developmentally regulated signaling components also contribute to TCR-induced lymphocyte activation. ..
- Avner E. Epithelial polarity and differentiation in polycystic kidney disease. J Cell Sci Suppl. 1993;17:217-22 pubmed..If such apically expressed enzyme is active, it may have pathogenic import in collecting tubule cyst formation and enlargement by mediating net basal to apical vectorial solute and fluid transport. ..
- Yablonka Reuveni Z, Schwartz S, Christ B. Development of chicken aortic smooth muscle: expression of cytoskeletal and basement membrane proteins defines two distinct cell phenotypes emerging from a common lineage. Cell Mol Biol Res. 1995;41:241-9 pubmed..We conclude that the aortic smooth muscle cells from "late" chicken embryos consist of two distinct cell phenotypes which are derived from a common lineage. ..
- Malkki M, Laakso M, Deeb S. The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM. Diabetologia. 1997;40:1461-9 pubmed..In addition, the region between -215 and -184 contains a negative regulatory element for expression in 3T3F442A but not in C2C12F3 cells. ..
- Wu J, Woods P, Eyre D. Identification of cross-linking sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type IX bonding. J Biol Chem. 1992;267:23007-14 pubmed..These data provide a molecular basis for the proposed function of type IX collagen as a critical contributor to the mechanical stability and resistance to swelling of the collagen type II fibril framework of cartilage. ..
- Cooke M, Abraham K, Forbush K, Perlmutter R. Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell. 1991;65:281-91 pubmed..Our results suggest that p59fyn is a critically important component of the TCR signal transduction apparatus. ..
- Yan C, Zhao A, Bentley J, Loughney K, Ferguson K, Beavo J. Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc Natl Acad Sci U S A. 1995;92:9677-81 pubmed..The high affinity for cAMP of this Ca2+/calmodulin-dependent PDE and the fact that its mRNA is highly concentrated in olfactory sensory neurons suggest an important role for it in a Ca(2+)-regulated olfactory signal termination. ..
- Hankenson K, Bornstein P. The secreted protein thrombospondin 2 is an autocrine inhibitor of marrow stromal cell proliferation. J Bone Miner Res. 2002;17:415-25 pubmed..We conclude that the increased endosteal bone formation observed in TSP2-null mice results primarily from the failure of TSP2 to regulate locally MSC cell cycle progression. ..
- Sindelar D, Ste Marie L, Miura G, Palmiter R, McMinn J, Morton G, et al. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology. 2004;145:3363-8 pubmed..We conclude that NPY signaling is required for hyperphagic feeding, but not neuroendocrine responses to moderate hypoglycemia. ..
- Thakker M, Usha K. Orbital foreign body and ruptured globe from needlefish impalement. Arch Ophthalmol. 2006;124:284 pubmed
- Yasuda G, Baker J, Schubiger G. Independent roles of centrosomes and DNA in organizing the Drosophila cytoskeleton. Development. 1991;111:379-91 pubmed..We speculate that the principles of cytoskeleton organization in this system may be different from those of the Xenopus "open" mitotic system. ..
- Haydock P, Blomquist C, Brumbaugh S, Dale B, Holbrook K, Fleckman P. Antisense profilaggrin RNA delays and decreases profilaggrin expression and alters in vitro differentiation of rat epidermal keratinocytes. J Invest Dermatol. 1993;101:118-26 pubmed..We conclude that, rather than producing the ichthyosis vulgaris phenotype, antisense profilaggrin RNA has more broad-reaching effects on in vitro differentiation of rat epidermal keratinocytes. ..
- Yamashita H, Oesterle E. Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor. Proc Natl Acad Sci U S A. 1995;92:3152-5 pubmed..These observations suggest that stimulation of the EGF receptors by TGF-alpha binding, or EGF (plus insulin) binding, stimulates cell proliferation in the mature mammalian vestibular sensory epithelium. ..
- Wang Y, Thouless M. Use of polymerase chain reaction for diagnosis of type D simian retrovirus infection in macaque blood. Lab Anim Sci. 1996;46:187-92 pubmed..The PCR analysis of 39 whole blood samples correctly identified five SRV-1 and nine SRV-2 culture-positive samples. It also detected SRV-2 in two culture-negative blood samples from monkeys from which SRV had been previously isolated...
- Larkin M, Holder K, Yost C, Giniger E, Ruohola Baker H. Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte. Development. 1996;122:3639-50 pubmed..We also find that expression of constitutively active Notch in follicle cells at later stages leads to a defect in the anterior-posterior axis of the oocyte. ..
- Cochran R, Kunzelman K, Vocelka C, Akimoto H, Thomas R, Soltow L, et al. Perfluorocarbon emulsion in the cardiopulmonary bypass prime reduces neurologic injury. Ann Thorac Surg. 1997;63:1326-32 pubmed..The addition of perfluorocarbon emulsion to the cardiopulmonary bypass prime solution leads to a reduction in the incidence and severity of neurologic injury after the formation of a massive air embolism during bypass. ..
- Yokoyama K, Trobridge P, Buckner F, Scholten J, Stuart K, Van Voorhis W, et al. The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth. Mol Biochem Parasitol. 1998;94:87-97 pubmed..mexicana insect form (promastigote) is modestly inhibited by protein farnesyltransferase inhibitors. These results suggest the potential for the development of PFT inhibitors for treating trypanosomiasis and leishmaniasis...
- Komada M, McLean D, Griswold M, Russell L, Soriano P. E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Genes Dev. 2000;14:1332-42 pubmed
- Agah A, Kyriakides T, Lawler J, Bornstein P. The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice. Am J Pathol. 2002;161:831-9 pubmed..These findings reflect distinct temporal and spatial expressions of TSP1 and TSP2 in the healing wound. ..
- de la Iglesia H. In situ hybridization of suprachiasmatic nucleus slices. Methods Mol Biol. 2007;362:513-31 pubmed..The second method is based on the radioactive labeling of mRNA and is more sensitive and more adequate for the relative quantification of mRNA species. ..
- Ieronimakis N, Hays A, Reyes M. Bone marrow-derived cells do not engraft into skeletal muscle microvasculature but promote angiogenesis after acute injury. Exp Hematol. 2012;40:238-249.e3 pubmed publisher..Therefore, despite the absence of BM engraftment to regenerated skeletal muscle microvasculature, macrophages recruited after injury promote angiogenesis and, in turn, vascular regeneration...
- Baena Del Valle J, Zheng Q, Hicks J, Fedor H, Trock B, Morrissey C, et al. Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides. Am J Clin Pathol. 2017;148:398-415 pubmed publisher..Current practice for FFPE block storage is to maintain them at room temperature, often for many years...
- Gombart A, Hirano A, Wong T. Expression and properties of the V protein in acute measles virus and subacute sclerosing panencephalitis virus strains. Virus Res. 1992;25:63-78 pubmed..These results suggest that expression and properties of the V protein are conserved in chronic MV infection...
- Edgar B, Odell G, Schubiger G. Cytoarchitecture and the patterning of fushi tarazu expression in the Drosophila blastoderm. Genes Dev. 1987;1:1226-37 pubmed..We conclude that RNA degradation and cellular structure normally work together to localize ftz RNA to its sites of synthesis...
- Harris C, Stark K, Juchau M. Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro. Teratology. 1988;37:577-90 pubmed
- Kaushansky K. The mpl ligand: molecular and cellular biology of the critical regulator of megakaryocyte development. Stem Cells. 1994;12 Suppl 1:91-6; discussion 96-7 pubmed..Following receptor engagement, ML induces tyrosine phosphorylation of a number of membrane associated kinases and adaptor molecules, including SHC, JAK2, PLC-gamma and the mpl receptor itself.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Saari J, Champer R, Asson Batres M, Garwin G, Huang J, Crabb J, et al. Characterization and localization of an aldehyde dehydrogenase to amacrine cells of bovine retina. Vis Neurosci. 1995;12:263-72 pubmed..The results provide further evidence for metabolism and function of retinoids within cells of the inner retina and define a novel class of retinal amacrine cells. ..
- Riddiford L. Hormone receptors and the regulation of insect metamorphosis. Receptor. 1993;3:203-9 pubmed..This JHR represents a new class of intranuclear hormone receptors since it has no known DNA-binding domains and has a discrete subnuclear localization different from that of the EcR. Its specific action is unknown. ..
- Tsuchiya K, Mulcahy R, Reid L, Disteche C, Kavanagh T. Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 1995;30:630-2 pubmed
- Otipoby K, Andersson K, Draves K, Klaus S, Farr A, Kerner J, et al. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature. 1996;384:634-7 pubmed..To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells. ..
- Street V, Bosma M, Demas V, Regan M, Lin D, Robinson L, et al. The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse. J Neurosci. 1997;17:635-45 pubmed..These data suggest that the convulsions and ataxia observed in opt mice may be caused by the physiological dysregulation of a functional IP3R1 protein. ..
- Kovats S, Grubin C, Eastman S, deRoos P, Dongre A, van Kaer L, et al. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med. 1998;187:245-51 pubmed..These findings are consistent with the idea that H-2M functions as a chaperone in the peptide loading of class II molecules in vivo. ..
- Kaftan E, Xu T, Abercrombie R, Hille B. Mitochondria shape hormonally induced cytoplasmic calcium oscillations and modulate exocytosis. J Biol Chem. 2000;275:25465-70 pubmed..Thus, we demonstrate a central role for mitochondria in a significant physiological response. ..
- Thomas J, Baneyx F. ClpB and HtpG facilitate de novo protein folding in stressed Escherichia coli cells. Mol Microbiol. 2000;36:1360-70 pubmed..coli cells, presumably by expanding the ability of the DnaK-DnaJ-GrpE team to interact with newly synthesized polypeptides. ..
- Robien M, Bosch J, Buckner F, Van Voorhis W, Worthey E, Myler P, et al. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Proteins. 2006;62:570-7 pubmed..This putative AEBSF molecule is positioned in a crucial location and hence our structure, with expected and unexpected ligands bound, can be of assistance in lead development and design of novel antimalarials. ..
- Duthie M, Gillis T, Reed S. Advances and hurdles on the way toward a leprosy vaccine. Hum Vaccin. 2011;7:1172-83 pubmed publisher..We summarize and discuss leprosy vaccine strategies that have been deployed previously and discuss those strategies that are currently being developed to augment recent breakthroughs in leprosy control...
- Eom D, Bain E, Patterson L, Grout M, Parichy D. Long-distance communication by specialized cellular projections during pigment pattern development and evolution. elife. 2015;4: pubmed publisher..Our study reveals a novel mechanism of cellular communication, roles for differentiation state heterogeneity in pigment cell interactions, and an unanticipated morphogenetic behavior contributing to a striking difference in adult form. ..
- Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, et al. Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circ Res. 2017;121:1182-1191 pubmed publisher..Increased γ2-AMPK activity is required to protect against ischemia/reperfusion injury. Our study reveals an isoform-specific function of γ2-AMPK in modulating ribosome biosynthesis, cell survival, and cardioprotection. ..
- Numann R, Catterall W, Scheuer T. Functional modulation of brain sodium channels by protein kinase C phosphorylation. Science. 1991;254:115-8 pubmed..Modulation of brain sodium channels by PKC is likely to have important effects on signal transduction and synaptic transmission in the central nervous system. ..
- Lindner V, Giachelli C, Schwartz S, Reidy M. A subpopulation of smooth muscle cells in injured rat arteries expresses platelet-derived growth factor-B chain mRNA. Circ Res. 1995;76:951-7 pubmed
- Maves L, Schubiger G. Wingless induces transdetermination in developing Drosophila imaginal discs. Development. 1995;121:1263-72 pubmed..This wingless-induced transdetermination event is remarkably similar to the leg-to-wing switch that occurs after leg disc culture. Thus we have identified a new approach to a molecular dissection of transdetermination. ..
- Disteche C. Escape from X inactivation in human and mouse. Trends Genet. 1995;11:17-22 pubmed..Questions about the mechanisms of 'escape' are relevant to the understanding of gene regulation by X inactivation. ..
- Madisen L, Groudine M. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev. 1994;8:2212-26 pubmed..These results suggest that HS1234 may function as a locus control region (LCR), deregulating c-myc expression in t(15;12) plasmacytomas, as well as potentially contributing to aspects of normal IgH chain expression. ..
- Hell J, Appleyard S, Yokoyama C, Warner C, Catterall W. Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini. J Biol Chem. 1994;269:7390-6 pubmed..Specific phosphorylation of the long form of the class B alpha 1 subunit by CaM kinase II may differentially regulate the function of N-type calcium channels containing different size forms of their alpha 1 subunits in vivo. ..
- Liska D, Hawkins R, Wikstrom K, Bornstein P. Modulation of thrombospondin expression during differentiation of embryonal carcinoma cells. J Cell Physiol. 1994;158:495-505 pubmed..The response of TSP1 and TSP2 to differentiation of P19EC cells indicates that this cell system will serve as a valuable model for the study of TSP expression and function during neurogenesis. ..
- Moon R, Campbell R, Christian J, McGrew L, Shih J, Fraser S. Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development. 1993;119:97-111 pubmed..The data are consistent with Xwnt-5A having the potential activity of modifying the morphogenetic movements of tissues. ..
- Verchere C, D Alessio D, Palmiter R, Weir G, Bonner Weir S, Baskin D, et al. Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci U S A. 1996;93:3492-6 pubmed..The frequent concordance of islet amyloid with hyperglycemia in these mice suggests an interdependence of these two conditions and supports the hypothesis that islet amyloid may play a role in the development of hyperglycemia. ..
- van Dijk G, Thiele T, Donahey J, Campfield L, Smith F, Burn P, et al. Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am J Physiol. 1996;271:R1096-100 pubmed
- Chamberlin H, Palmer R, Newman A, Sternberg P, Baillie D, Thomas J. The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans. Development. 1997;124:3919-28 pubmed..elegans development and also provides the opportunity to investigate the in vivo functions of this class of PAX proteins with single cell resolution. ..