Experts and Doctors on signal transduction in Salt Lake City, Utah, United States


Locale: Salt Lake City, Utah, United States
Topic: signal transduction

Top Publications

  1. Modur V, Li Y, Zimmerman G, Prescott S, McIntyre T. Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha. J Clin Invest. 1997;100:2752-6 pubmed
    ..Retrograde signaling from PMN activated in the extravascular compartment to surrounding endothelial cells will recruit more and a wider variety of leukocytes. The limiting signal is a soluble receptor, not a cytokine. ..
  2. Prescott S, Yost H. The COXes of Danio: from mechanistic model to experimental therapeutics. Proc Natl Acad Sci U S A. 2002;99:9084-6 pubmed
  3. Mellem J, Brockie P, Zheng Y, Madsen D, Maricq A. Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans. Neuron. 2002;36:933-44 pubmed
    ..Furthermore, analysis of the EGL-3 proprotein convertase provides additional evidence that polymodal signaling in C. elegans occurs via the differential activation of postsynaptic glutamate receptor subtypes. ..
  4. Van Norman J, Sieburth L. Dissecting the biosynthetic pathway for the bypass1 root-derived signal. Plant J. 2007;49:619-28 pubmed
    ..Together, our results suggest that bps1 roots produce a novel mobile carotenoid-derived signaling compound...
  5. Wang G, Scott S. Onset of ETS expression is not accelerated by premature exposure to signals from limb mesenchyme. Dev Dyn. 2007;236:2109-17 pubmed
  6. Chow K, Factor R, Ullman K. The nuclear envelope environment and its cancer connections. Nat Rev Cancer. 2012;12:196-209 pubmed publisher
    ..In this Review, we summarize the progress that has been made in our understanding of the nuclear envelope and the implications of changes in this environment for cancer biology...
  7. Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson M, et al. The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet. 2017;49:1211-1218 pubmed publisher
    ..This genomic landscape provides a logical framework for the development of faithful genetic models and new therapeutic approaches. ..
  8. Chen L, Zhu J, Schumacher J, Wei C, Ramdas L, Prieto V, et al. SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions. PLoS ONE. 2017;12:e0184154 pubmed publisher
    ..New strategies (e.g. enhancing the KIT-ET3-NO pathway) to harness the benefit of endogenous eNOS and nNOS activation and precise NO generation for correcting pathophysiology and restoring functions warrant investigation. ..
  9. Chen C. Recoverin and rhodopsin kinase. Adv Exp Med Biol. 2002;514:101-7 pubmed
    ..This interaction imparts a negative feedback loop at the receptor level and may play an important role in light adaptation and in recovery. ..

More Information

Publications265 found, 100 shown here

  1. Swiatek W, Kang H, Garcia B, Shabanowitz J, Coombs G, Hunt D, et al. Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. J Biol Chem. 2006;281:12233-41 pubmed
    ..Generation of active CKIepsilon may induce a negative feedback loop by phosphorylation of sites on LRP5/6 that modulate axin binding and hence beta-catenin degradation. ..
  2. Zhang T, Daynes R. Macrophages from 11beta-hydroxysteroid dehydrogenase type 1-deficient mice exhibit an increased sensitivity to lipopolysaccharide stimulation due to TGF-beta-mediated up-regulation of SHIP1 expression. J Immunol. 2007;179:6325-35 pubmed
    ..Our results suggest that modest elevations in plasma GC levels can modify the LPS responsiveness of Mphi by augmenting SHIP1 expression through a TGF-beta-dependent mechanism. ..
  3. Slattery M, Lundgreen A, Wolff R, Herrick J, Caan B. Genetic variation in the transforming growth factor-?-signaling pathway, lifestyle factors, and risk of colon or rectal cancer. Dis Colon Rectum. 2012;55:532-40 pubmed publisher
    ..Although the integrity of the pathway can be diminished by a number of high-risk genotypes, this risk can be offset, in part, by maintaining a healthy lifestyle. ..
  4. Han X, Parkinson J. An unorthodox sensory adaptation site in the Escherichia coli serine chemoreceptor. J Bacteriol. 2014;196:641-9 pubmed publisher
    ..These findings are consistent with control of input-output signaling in Tsr through dynamic interplay of the structural stabilities of the HAMP and methylation bundles. ..
  5. Kozlova T, Thummel C. Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science. 2003;301:1911-4 pubmed
    ..It also provides an intriguing parallel with the role of mammalian extraembryonic tissues as a critical source of steroid hormones during embryonic development. ..
  6. Zimmerman G, McIntyre T. PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. Trends Mol Med. 2004;10:245-8 pubmed
  7. King Jones K, Thummel C. Developmental biology. Less steroids make bigger flies. Science. 2005;310:630-1 pubmed
  8. Smith R, Young J, Weis J, Weis J. Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes. Genes Immun. 2006;7:113-21 pubmed
    ..The mouse functional equivalent to human Leu-13 may not be single gene product, but instead may require the contribution of multiple fragilis proteins. ..
  9. Park E, Ogden L, Talbot A, Evans S, Cai C, Black B, et al. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development. 2006;133:2419-33 pubmed
    ..These findings provide a novel insight into how the formation and remodeling of primary and anterior heart field-derived structures rely on Fgf8 signals from discrete temporospatial domains. ..
  10. Bisgrove B, Yost H. The roles of cilia in developmental disorders and disease. Development. 2006;133:4131-43 pubmed
    ..Here, we summarize an emerging view that in order to understand some complex developmental pathways and disease etiologies, one must consider the molecular functions performed by cilia. ..
  11. Gallego M, Virshup D. Post-translational modifications regulate the ticking of the circadian clock. Nat Rev Mol Cell Biol. 2007;8:139-48 pubmed
    ..Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them. ..
  12. Campanelli J, Sandrock R, Wheatley W, Xue H, Zheng J, Liang F, et al. Expression profiling of human glial precursors. BMC Dev Biol. 2008;8:102 pubmed publisher
    ..Such information may be utilized to further purify glial precursor populations, optimize media formulation, or study the effects of glial differentiation. ..
  13. Thyagarajan B, Blaszczak A, Chandler K, Watts J, Johnson W, Graves B. ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. PLoS Genet. 2010;6:e1001125 pubmed publisher
    ..In conclusion, ETS-4 is a new transcriptional regulator of aging, which shares transcriptional targets with GATA and FOXO factors, suggesting that overlapping pathways direct common sets of lifespan-related genes. ..
  14. Yoo Y, Christensen J, Gu J, Huang L. HIF-1? mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression. Sci Signal. 2011;4:pt4 pubmed publisher
    ..Hence, these results reveal a mechanism by which HIF-1? promotes a perpetual mesenchymal phenotype, thereby advancing tumor progression. ..
  15. Chandra P, Bao L, Song K, Aboulnasr F, Baker D, Shores N, et al. HCV infection selectively impairs type I but not type III IFN signaling. Am J Pathol. 2014;184:214-29 pubmed publisher
    ..The results also indicate that inhibition of ER stress and of the autophagy response overcomes IFN-?+RBV resistance mechanisms associated with HCV infection. ..
  16. Singh V, Jaini R, Torricelli A, Santhiago M, Singh N, Ambati B, et al. TGF? and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells in vivo. Exp Eye Res. 2014;121:35-40 pubmed publisher
    ..TGF? and PDGF regulate corneal myofibroblast development from bone marrow-derived precursor cells and keratocyte/corneal fibroblast-derived precursor cells. ..
  17. Mauch T, Yang G, Wright M, Smith D, Schoenwolf G. Signals from trunk paraxial mesoderm induce pronephros formation in chick intermediate mesoderm. Dev Biol. 2000;220:62-75 pubmed
    ..Studies to identify the molecular nature of the induction are in progress...
  18. Lee J, Ray R, Chien C. Cloning and expression of three zebrafish roundabout homologs suggest roles in axon guidance and cell migration. Dev Dyn. 2001;221:216-30 pubmed
    ..They are also expressed in several nonneuronal tissues, including somites and fin buds. The timing and patterns of expression suggest roles for zebrafish robos in axon guidance and cell migration. Wiley-Liss, Inc. ..
  19. Zimmerman G, Weyrich A. Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function. Arterioscler Thromb Vasc Biol. 2008;28:s17-24 pubmed publisher
    ..Signal-dependent translation and consequent protein synthesis are examples of a diverse group of posttranscriptural mechanisms in activated platelets that are now being revealed. ..
  20. Zhou Q, Ames P, Parkinson J. Mutational analyses of HAMP helices suggest a dynamic bundle model of input-output signalling in chemoreceptors. Mol Microbiol. 2009;73:801-14 pubmed publisher
    ..This study shows how transmembrane signalling and HAMP input-output control could occur without the helix rotations central to the gearbox model. ..
  21. Coon V, Laukert T, Pedone C, Laterra J, Kim K, Fults D. Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma. Mol Cancer Ther. 2010;9:2627-36 pubmed publisher
  22. Choudhry P, Joshi D, Funke B, Trede N. Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev Biol. 2011;349:483-93 pubmed publisher
    ..1 during chondrogenesis. Collectively our results support a model by which Alcama on the endoderm interacts with Nadl1.1 on NC to mediate Edn1 signaling and NC differentiation during chondrogenesis. ..
  23. Aman A, Piotrowski T. Cell-cell signaling interactions coordinate multiple cell behaviors that drive morphogenesis of the lateral line. Cell Adh Migr. 2011;5:499-508 pubmed publisher
    ..In this review, we summarize the signaling network that patterns the migrating lateral line primordium and describe how this patterning coordinates crucial morphogenic cell behaviors. ..
  24. Mendez J, Mindlin G, Goller F. Interaction between telencephalic signals and respiratory dynamics in songbirds. J Neurophysiol. 2012;107:2971-83 pubmed publisher
  25. Ruiz O, Nikolova L, Metzstein M. Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation. PLoS ONE. 2012;7:e45649 pubmed publisher
    ..Finally, we show that down-regulation of Smn, a protein known to interact with Zpr1 in mammalian cells, shows defects similar to Zpr1 mutants. ..
  26. Wooderchak Donahue W, McDonald J, O Fallon B, Upton P, Li W, Roman B, et al. BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia. Am J Hum Genet. 2013;93:530-7 pubmed publisher
    ..These data confirm a genetic cause of a vascular-anomaly syndrome that has phenotypic overlap with HHT...
  27. Xie Y, Dorsky R. Development of the hypothalamus: conservation, modification and innovation. Development. 2017;144:1588-1599 pubmed publisher
  28. Jia S, Zhou J, Wee Y, Mikkola M, Schneider P, D Souza R. Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9-/- Mice. J Dent Res. 2017;96:1282-1289 pubmed publisher
  29. Parkinson J, Kofoid E. Communication modules in bacterial signaling proteins. Annu Rev Genet. 1992;26:71-112 pubmed
  30. Scuderi A, Simin K, Kazuko S, Metherall J, Letsou A. scylla and charybde, homologues of the human apoptotic gene RTP801, are required for head involution in Drosophila. Dev Biol. 2006;291:110-22 pubmed
  31. Michel W, Derbidge D. Evidence of distinct amino acid and bile salt receptors in the olfactory system of the zebrafish, Danio rerio. Brain Res. 1997;764:179-87 pubmed
    ..Presumably, the differences in the extent of partial adaptation are due to differences in the transduction cascades activated or the distribution of odorant receptors on individual olfactory receptor neurons. ..
  32. Lindemann S, Tolley N, Dixon D, McIntyre T, Prescott S, Zimmerman G, et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol. 2001;154:485-90 pubmed
  33. Marathe G, Johnson C, Billings S, Southall M, Pei Y, Spandau D, et al. Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage. J Biol Chem. 2005;280:35448-57 pubmed
    ..PAF signaling may participate in the cutaneous inflammation that occurs during photo-aggravated dermatoses. ..
  34. Zhang T, Daynes R. Glucocorticoid conditioning of myeloid progenitors enhances TLR4 signaling via negative regulation of the phosphatidylinositol 3-kinase-Akt pathway. J Immunol. 2007;178:2517-26 pubmed
    ..Our results suggest that minor fluctuations in physiological levels of endogenous GCs can program endotoxin-responsive hemopoietic cells during their differentiation by regulating their sensitivity to stimulation. ..
  35. Paxton C, Bleyl S, Chapman S, Schoenwolf G. Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns. 2010;10:31-43 pubmed publisher
    ..In conclusion, we identified a number of novel candidate genes for otic placode induction. ..
  36. Dhakal B, Mulvey M. The UPEC pore-forming toxin ?-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways. Cell Host Microbe. 2012;11:58-69 pubmed publisher
    ..HlyA-induced proteolysis of host proteins likely allows UPEC to not only modulate epithelial cell functions, but also disable macrophages and suppress inflammatory responses...
  37. Crotty T, Nakano T, Stafforini D, Topham M. Diacylglycerol kinase ? modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2). J Biol Chem. 2013;288:1439-47 pubmed publisher
    ..Our collective data indicate that DGK? is a pertinent cancer target, and our studies could lay the groundwork for development of novel cancer therapeutics. ..
  38. Neugebauer J, Cadwallader A, Amack J, Bisgrove B, Yost H. Differential roles for 3-OSTs in the regulation of cilia length and motility. Development. 2013;140:3892-902 pubmed publisher
    ..We propose that individual 3-OST isozymes create distinct modified domains or 'glycocodes' on cell surface proteoglycans, which in turn regulate the response to diverse cell signaling pathways. ..
  39. Zhang Y, Liu C, Barbier O, Smalling R, Tsuchiya H, Lee S, et al. Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function. Sci Rep. 2016;6:20559 pubmed publisher
    ..We demonstrated for the first time a detrimental effect of Bcl2 and H19 associated with cholestatic liver fibrosis and an indispensable role of Shp to maintain normal liver function. ..
  40. Jiang H, Weyrich A, Zimmerman G, McIntyre T. Endothelial cell confluence regulates cyclooxygenase-2 and prostaglandin E2 production that modulate motility. J Biol Chem. 2004;279:55905-13 pubmed
  41. Gu Y, Forostyan T, Sabbadini R, Rosenblatt J. Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. J Cell Biol. 2011;193:667-76 pubmed publisher
    ..Because live cells can also be extruded, we predict that this S1P pathway may also be important for driving delamination of stem cells during differentiation or invasion of cancer cells...
  42. Norman K, Fazzio R, Mellem J, Espelt M, Strange K, Beckerle M, et al. The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell. 2005;123:119-32 pubmed
  43. Vickers N. Inheritance of olfactory preferences III. Processing of pheromonal signals in the antennal lobe of Heliothis subflexa x Heliothis virescens hybrid male moths. Brain Behav Evol. 2006;68:90-108 pubmed
    ..subflexa males, signifying a dominant effect of H. subflexa genes. These results indicate that the behavioral phenotype of hybrid males can be linked to underlying central olfactory characteristics. ..
  44. Zimmerman E, Sherman M, Blackett J, Neidleman J, Kreis C, Mundt P, et al. Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo. J Virol. 2006;80:10407-18 pubmed
    ..We report that infected cells in vivo display an aberrant cell cycle profile whereby a majority of cells have a 4N DNA content, consistent with the onset of G2 arrest. ..
  45. Shi L, Wang S, Zangari M, Xu H, Cao T, Xu C, et al. Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance. Oncotarget. 2010;1:22-33 pubmed
    ..Thus, our findings provide a rationale for targeting STAT3 and MEK/ERK/BCL2 signaling in aggressive CKS1B-overexpressing MM. ..
  46. Lin Y, Jones B, Liu A, Tucker J, Rapp K, Luo L, et al. Retinoid receptors trigger neuritogenesis in retinal degenerations. FASEB J. 2012;26:81-92 pubmed publisher
    ..Thus, RXRs are in the final common path and may be therapeutic targets to attenuate retinal remodeling and facilitate global intervention methods in blinding diseases and other neurodegenerative disorders. ..
  47. Lee S, Day N, Miles R, Perkins S, Lim M, Ayello J, et al. Comparative genomic expression signatures of signal transduction pathways and targets in paediatric Burkitt lymphoma: a Children's Oncology Group report. Br J Haematol. 2017;177:601-611 pubmed publisher
    ..These pre-clinical results suggest that specific signal transduction pathways are overly expressed in PEBL and several pathways could serve as potential future therapeutic targets. ..
  48. Regier D, Higbee J, Lund K, Sakane F, Prescott S, Topham M. Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proc Natl Acad Sci U S A. 2005;102:7595-600 pubmed
    ..Thus, type IV DGKs regulate RasGRPs, but the downstream effects differ depending on the DGK. ..
  49. Van Tassell B, Rondina M, Huggins F, Gilbert E, Munger M. Carvedilol increases blood pressure response to phenylephrine infusion in heart failure subjects with systolic dysfunction: evidence of improved vascular alpha1-adrenoreceptor signal transduction. Am Heart J. 2008;156:315-21 pubmed publisher
    ..This effect is evident despite no detectable tolerance to preinfusion BP reductions. The varying affinities of alpha(1)-AR subtypes for carvedilol and PE may have contributed to this finding. ..
  50. WARREN J, Oka S, Zablocki D, Sadoshima J. Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigenetics. Am J Physiol Heart Circ Physiol. 2017;313:H584-H596 pubmed publisher
    ..In addition, we discuss how metabolomics can contribute to a better understanding of the role of PPARα in the progression of cardiac hypertrophy and failure. ..
  51. Letsou A, Arora K, Wrana J, Simin K, Twombly V, Jamal J, et al. Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Cell. 1995;80:899-908 pubmed
    ..We suggest that punt functions as a type II receptors for dpp and propose that BMP signaling in vertebrates may also involve sharing of type II receptors by diverse ligands. ..
  52. Zhang F, White R, Neufeld K. Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Mol Cell Biol. 2001;21:8143-56 pubmed
    ..Our data provide evidence that physiological signals such as cell density regulate APC's nuclear distribution, with phosphorylation sites near NLS2(APC) being critical for this regulation. ..
  53. Zhang Y, Nelson R, Carlson N, Kamerath C, Kohan D, Kishore B. Potential role of purinergic signaling in lithium-induced nephrogenic diabetes insipidus. Am J Physiol Renal Physiol. 2009;296:F1194-201 pubmed publisher
    ..Our study also reveals the potential beneficial effects of P(2y) receptor antagonists in the treatment and/or prevention of Li-induced NDI. ..
  54. Symons J, McMillin S, Riehle C, Tanner J, Palionyte M, Hillas E, et al. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res. 2009;104:1085-94 pubmed publisher
  55. Taha S. Preference or fat? Revisiting opioid effects on food intake. Physiol Behav. 2010;100:429-37 pubmed publisher
    ..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. ..
  56. Ohta S, Mansour S, Schoenwolf G. BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst. Dev Biol. 2010;347:369-81 pubmed publisher
  57. Adams A, Keefe K. Examination of the involvement of protein kinase A in D2 dopamine receptor antagonist-induced immediate early gene expression. J Neurochem. 2001;77:326-35 pubmed
    ..These data suggest that PKA activation may not be necessary for induction of IEGs by D2 dopamine receptor antagonists and that other intracellular signaling pathways may be involved. ..
  58. Hills T, Brockie P, Maricq A. Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J Neurosci. 2004;24:1217-25 pubmed
    ..We propose a mechanism for ARS in C. elegans in which dopamine, released in response to food, modulates glutamatergic signaling in the locomotory control circuit, thus resulting in an increased turn frequency. ..
  59. Luo B, Regier D, Prescott S, Topham M. Diacylglycerol kinases. Cell Signal. 2004;16:983-9 pubmed
    ..By modulating the activity of these proteins, DGKs potentially affect a number of biological events including-but likely not limited to-cell growth, neuronal transmission, and cytoskeleton remodeling. ..
  60. Sturrock A, Huecksteadt T, Norman K, Sanders K, Murphy T, Chitano P, et al. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1543-55 pubmed
  61. Karim F, Thummel C. Ecdysone coordinates the timing and amounts of E74A and E74B transcription in Drosophila. Genes Dev. 1991;5:1067-79 pubmed
  62. Kadrmas J, Smith M, Clark K, Pronovost S, Muster N, Yates J, et al. The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol. 2004;167:1019-24 pubmed
    ..Genetic interaction analyses reveal that both PINCH and RSU-1 antagonize JNK signaling during DC. Our results suggest that PINCH and RSU-1 contribute to the integration of JNK and integrin functions during Drosophila development. ..
  63. Miller J, Ma Y, Bian J, Sheehan K, Zachary J, Weis J, et al. A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice. J Immunol. 2008;181:8492-503 pubmed
    ..burgdorferi uses a previously unidentified receptor and a pathway traditionally associated with viruses and intracellular bacteria to initiate transcription of type I IFN and IFN-responsive genes and to initiate arthritis development. ..
  64. Li D, Sorensen L, Brooke B, Urness L, Davis E, Taylor D, et al. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534-7 pubmed
    ..Loss of endoglin caused poor vascular smooth muscle development and arrested endothelial remodeling. These results demonstrate that endoglin is essential for angiogenesis and suggest a pathogenic mechanism for HHT1. ..
  65. Kishore B, Isaac J, Fausther M, Tripp S, Shi H, Gill P, et al. Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling. Am J Physiol Renal Physiol. 2005;288:F1032-43 pubmed
    ..NTPDases may modulate regulatory effects of ATP and degradation products within the vasculature and other sites and thereby potentially influence physiological as well as multiple pathological events in the kidney. ..
  66. Teng D, Perry W, Hogan J, Baumgard M, Bell R, Berry S, et al. Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res. 1997;57:4177-82 pubmed
    ..Thus, the incidence of coding mutations of MKK4 in the set of cell lines is 6 of 213 (approximately 3%). These findings suggest that MKK4 may function as a suppressor of tumorigenesis or metastasis in certain types of cells. ..
  67. Sturrock A, Cahill B, Norman K, Huecksteadt T, Hill K, Sanders K, et al. Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006;290:L661-L673 pubmed
    ..These findings suggest that Nox4 is the relevant Nox homolog in HPASMC. This is the first observation that TGF-beta1 regulates Nox4, with important implications for mechanisms of pulmonary vascular remodeling. ..
  68. Gu F, Zhang H, Hyland P, Berndt S, Gapstur S, Wheeler W, et al. Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia. Int J Cancer. 2017;141:1794-1802 pubmed publisher
    ..These findings support a potential role for circadian rhythm and melatonin pathways in prostate carcinogenesis. Further functional studies are needed to better understand the underlying biologic mechanisms. ..
  69. Schell J, Wisidagama D, Bensard C, Zhao H, Wei P, Tanner J, et al. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nat Cell Biol. 2017;19:1027-1036 pubmed publisher
    ..These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells. ..
  70. Poynter M, Daynes R. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem. 1998;273:32833-41 pubmed
    ..Our results suggest that PPARalpha and the genes under its control play a role in the evolution of oxidative stress excesses observed in aging. ..
  71. Wang G, Scott S. An early broad competence of motoneurons to express ER81 is later sculpted by the periphery. J Neurosci. 2004;24:9789-98 pubmed
  72. Scaife C, SHEA J, Emerson L, Boucher K, Firpo M, Beckerle M, et al. Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma. HPB (Oxford). 2010;12:352-8 pubmed publisher
    ..Additionally, the importance of the differential expression of PINCH in the human tumour and stroma warrants further evaluation. ..
  73. Thorburn J, Xu S, Thorburn A. MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells. EMBO J. 1997;16:1888-900 pubmed
    ..Positive and negative signals mediated by parallel MAP kinase cascades interact with Rho-dependent pathways to regulate hypertrophic gene expression while other signals induce muscle fiber morphology in cardiac muscle cells. ..
  74. Scuderi A, Letsou A. Amnioserosa is required for dorsal closure in Drosophila. Dev Dyn. 2005;232:791-800 pubmed
  75. Mowery P, Ostler J, Parkinson J. Different signaling roles of two conserved residues in the cytoplasmic hairpin tip of Tsr, the Escherichia coli serine chemoreceptor. J Bacteriol. 2008;190:8065-74 pubmed publisher
    ..These findings demonstrate that the receptor determinants for CheA and CheW binding probably lie outside the hairpin tip of the receptor signaling domain. ..
  76. Trang S, Joyner D, Damron T, Aboulafia A, Randall R. Potential for functional redundancy in EGF and TGFalpha signaling in desmoid cells: a cDNA microarray analysis. Growth Factors. 2010;28:10-23 pubmed
    ..Approximately 150 genes costimulated by rhEGF and rhTGFalpha were identified. This study suggests that EGF and TGFalpha retain some level of functional redundancy, possibly resulting from their divergence from a common ancestral gene. ..
  77. London N, Zhu W, Bozza F, Smith M, Greif D, Sorensen L, et al. Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med. 2010;2:23ra19 pubmed publisher
    ..Thus, enhancing the resilience of the host vascular system to the host's innate immune response may provide a therapeutic strategy for treating multiple infectious agents. ..
  78. Eisinger A, Prescott S, Jones D, Stafforini D. The role of cyclooxygenase-2 and prostaglandins in colon cancer. Prostaglandins Other Lipid Mediat. 2007;82:147-54 pubmed
    ..This review will focus on the regulation of COX-2 by APC and the interplay between COX-2 and the Wnt signaling pathway. ..
  79. Liu J, Stevens J, Rote C, Yost H, Hu Y, Neufeld K, et al. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell. 2001;7:927-36 pubmed
    ..These results indicate that APC and Siah-1 mediate a novel beta-catenin degradation pathway linking p53 activation to cell cycle control. ..
  80. Luo B, Prescott S, Topham M. Association of diacylglycerol kinase zeta with protein kinase C alpha: spatial regulation of diacylglycerol signaling. J Cell Biol. 2003;160:929-37 pubmed
    ..Together, our results suggest that DGKzeta spatially regulates PKCalpha activity by attenuating local accumulation of signaling DAG. This regulation is impaired by PKCalpha-mediated DGKzeta phosphorylation. ..
  81. Garrison S, Hojgaard A, Margraf R, Weis J, Weis J. Surface translocation of pactolus is induced by cell activation and death, but is not required for neutrophil migration and function. J Immunol. 2003;171:6795-806 pubmed
    ..These data suggest that Pactolus does not function as a neutrophil phagocytic or adhesion receptor, but may instead serve as a sugar-bearing ligand for lectin recognition by other cells. ..
  82. Zhang Y, Kohan D, Nelson R, Carlson N, Kishore B. Potential involvement of P2Y2 receptor in diuresis of postobstructive uropathy in rats. Am J Physiol Renal Physiol. 2010;298:F634-42 pubmed publisher
    ..Increased mRNA expression of EP1 and EP3 receptors in POU may also help accentuate PGE2-induced signaling in the mCD. ..
  83. Gounder S, Kannan S, Devadoss D, Miller C, Whitehead K, Whitehead K, et al. Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS ONE. 2012;7:e45697 pubmed publisher
    ..These observations suggest that enhancing Nrf2 function and endogenous cytoprotective mechanisms by MET, may combat age-induced ROS/RNS and protect the myocardium from oxidative stress diseases. ..
  84. Topham M, Prescott S. Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions. J Biol Chem. 1999;274:11447-50 pubmed
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