Experts and Doctors on pupa in Salt Lake City, Utah, United States

Summary

Locale: Salt Lake City, Utah, United States
Topic: pupa

Top Publications

  1. Lam G, Jiang C, Thummel C. Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis. Development. 1997;124:1757-69 pubmed
  2. D Avino P, Thummel C. crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis. Development. 1998;125:1733-45 pubmed
    ..The genetic criteria described here provide a new direction for identifying regulators of adult tissue development during insect metamorphosis. ..
  3. Rohrbough J, Pinto S, Mihalek R, Tully T, Broadie K. latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron. 1999;23:55-70 pubmed
    ..Our results suggest that LAT is a novel presynaptic protein with a role in the Ca2(+)-dependent synaptic modulation mechanisms necessary for behavioral plasticity. ..
  4. Ward R, Reid P, Bashirullah A, D Avino P, Thummel C. GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Dev Biol. 2003;256:389-402 pubmed
    ..This approach provides a new tool for characterizing the dynamic morphological changes that occur during metamorphosis in both wild-type and mutant animals. ..
  5. Gates J, Lam G, Ortiz J, Losson R, Thummel C. rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development. 2004;131:25-36 pubmed
    ..Furthermore, the dynamic intracellular redistribution of Rig protein suggests that it may act to refine spatial and temporal responses to ecdysone during development. ..
  6. Kozlova T, Lam G, Thummel C. Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion. Dev Dyn. 2009;238:701-7 pubmed publisher
    ..In contrast, cuticle gene expression is significantly reduced in DHR38(Y214) mutant pupae. These studies define the essential functions of DHR38 and provide a genetic context for further characterization of its roles during development. ..
  7. Woodard C, Baehrecke E, Thummel C. A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone. Cell. 1994;79:607-15 pubmed
    ..These findings indicate that beta FTZ-F1 plays a central role in the prepupal genetic response to ecdysone and provide a molecular mechanism for stage-specific responses to steroid hormones. ..
  8. King Jones K, Charles J, Lam G, Thummel C. The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila. Cell. 2005;121:773-84 pubmed
    ..We propose that DHR4 coordinates growth and maturation in Drosophila by mediating endocrine responses to the attainment of critical weight during larval development. ..
  9. Clark K, Bland J, Beckerle M. The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci. 2007;120:2066-77 pubmed
  10. Andres A, Thummel C. Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone. Trends Genet. 1992;8:132-8 pubmed
    ..Molecular characterization of some of these genes has provided valuable clues to regulatory mechanisms by which the ecdysone signal is transduced and amplified. ..

Detail Information

Publications15

  1. Lam G, Jiang C, Thummel C. Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis. Development. 1997;124:1757-69 pubmed
  2. D Avino P, Thummel C. crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis. Development. 1998;125:1733-45 pubmed
    ..The genetic criteria described here provide a new direction for identifying regulators of adult tissue development during insect metamorphosis. ..
  3. Rohrbough J, Pinto S, Mihalek R, Tully T, Broadie K. latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron. 1999;23:55-70 pubmed
    ..Our results suggest that LAT is a novel presynaptic protein with a role in the Ca2(+)-dependent synaptic modulation mechanisms necessary for behavioral plasticity. ..
  4. Ward R, Reid P, Bashirullah A, D Avino P, Thummel C. GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Dev Biol. 2003;256:389-402 pubmed
    ..This approach provides a new tool for characterizing the dynamic morphological changes that occur during metamorphosis in both wild-type and mutant animals. ..
  5. Gates J, Lam G, Ortiz J, Losson R, Thummel C. rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development. 2004;131:25-36 pubmed
    ..Furthermore, the dynamic intracellular redistribution of Rig protein suggests that it may act to refine spatial and temporal responses to ecdysone during development. ..
  6. Kozlova T, Lam G, Thummel C. Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion. Dev Dyn. 2009;238:701-7 pubmed publisher
    ..In contrast, cuticle gene expression is significantly reduced in DHR38(Y214) mutant pupae. These studies define the essential functions of DHR38 and provide a genetic context for further characterization of its roles during development. ..
  7. Woodard C, Baehrecke E, Thummel C. A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone. Cell. 1994;79:607-15 pubmed
    ..These findings indicate that beta FTZ-F1 plays a central role in the prepupal genetic response to ecdysone and provide a molecular mechanism for stage-specific responses to steroid hormones. ..
  8. King Jones K, Charles J, Lam G, Thummel C. The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila. Cell. 2005;121:773-84 pubmed
    ..We propose that DHR4 coordinates growth and maturation in Drosophila by mediating endocrine responses to the attainment of critical weight during larval development. ..
  9. Clark K, Bland J, Beckerle M. The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci. 2007;120:2066-77 pubmed
  10. Andres A, Thummel C. Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone. Trends Genet. 1992;8:132-8 pubmed
    ..Molecular characterization of some of these genes has provided valuable clues to regulatory mechanisms by which the ecdysone signal is transduced and amplified. ..
  11. Karim F, Guild G, Thummel C. The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis. Development. 1993;118:977-88 pubmed
    ..These studies define the BR-C as a key regulator of gene activity at the onset of metamorphosis in Drosophila. ..
  12. Broadus J, McCabe J, Endrizzi B, Thummel C, Woodard C. The Drosophila beta FTZ-F1 orphan nuclear receptor provides competence for stage-specific responses to the steroid hormone ecdysone. Mol Cell. 1999;3:143-9 pubmed
    ..This study define beta FTZ-F1 as an essential competence factor for stage-specific responses to a steroid signal and implicates interplay among nuclear receptors as a mechanism for achieving hormonal competence. ..
  13. Beckstead R, Lam G, Thummel C. The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biol. 2005;6:R99 pubmed
  14. Thummel C. Dueling orphans--interacting nuclear receptors coordinate Drosophila metamorphosis. Bioessays. 1997;19:669-72 pubmed
    ..This study provides a biological function for orphan receptor interactions during development. ..
  15. Beckstead R, Lam G, Thummel C. Specific transcriptional responses to juvenile hormone and ecdysone in Drosophila. Insect Biochem Mol Biol. 2007;37:570-8 pubmed
    ..These studies demonstrate that larval organ culture can be used to identify Drosophila genes that are regulated by hormones other than 20E, and provide a basis for studying crosstalk between multiple hormone signaling pathways. ..