Experts and Doctors on morphogenesis in Salt Lake City, Utah, United States


Locale: Salt Lake City, Utah, United States
Topic: morphogenesis

Top Publications

  1. Gu Y, Rosenblatt J. New emerging roles for epithelial cell extrusion. Curr Opin Cell Biol. 2012;24:865-70 pubmed publisher
    ..Here, we review recent advances in new processes that require cell extrusion and the signaling pathways controlling it. ..
  2. Lopez Sanchez C, Garcia Martinez V, Schoenwolf G. Localization of cells of the prospective neural plate, heart and somites within the primitive streak and epiblast of avian embryos at intermediate primitive-streak stages. Cells Tissues Organs. 2001;169:334-46 pubmed
  3. Aman A, Piotrowski T. Cell-cell signaling interactions coordinate multiple cell behaviors that drive morphogenesis of the lateral line. Cell Adh Migr. 2011;5:499-508 pubmed publisher
    ..In this review, we summarize the signaling network that patterns the migrating lateral line primordium and describe how this patterning coordinates crucial morphogenic cell behaviors. ..
  4. Park E, Watanabe Y, Smyth G, Miyagawa Tomita S, Meyers E, Klingensmith J, et al. An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development. 2008;135:3599-610 pubmed publisher
    ..These findings provide new insight into how FGF signaling regulates context-dependent cellular responses during development. ..
  5. Jimenez L, Wang J, Morrison M, Whatcott C, Soh K, Warner S, et al. Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis. Dis Model Mech. 2016;9:389-400 pubmed publisher
    ..These studies identify TP-0903 as a new therapeutic for activating RAin vivoand raise the possibility that RA-dependent inhibition of EMT contributes to its prior success in eliminating disseminated cancer cells. ..
  6. Kwan K, Otsuna H, Kidokoro H, Carney K, Saijoh Y, Chien C. A complex choreography of cell movements shapes the vertebrate eye. Development. 2012;139:359-72 pubmed publisher
    ..Finally, we find that similar movements also occur during chick eye morphogenesis, suggesting that the underlying choreography is conserved among vertebrates. ..
  7. Troadec M, Ward D, Kaplan J. A Tf-independent iron transport system required for organogenesis. Dev Cell. 2009;16:3-4 pubmed publisher this issue of Developmental Cell show that ferritin, through its binding to the cell surface Scara5 receptor, can also deliver iron to cells, permitting kidney organogenesis. ..
  8. Cetera M, Leybova L, Woo F, Deans M, Devenport D. Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns. Dev Biol. 2017;428:188-203 pubmed publisher
  9. Manley N, Capecchi M. Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol. 1997;192:274-88 pubmed
    ..This suggests that the identity of the specific Hox genes that are functional in a given region may not be as critical as the total number of Hox genes operating in that region. ..

More Information


  1. Li D, Brooke B, Davis E, Mecham R, Sorensen L, Boak B, et al. Elastin is an essential determinant of arterial morphogenesis. Nature. 1998;393:276-80 pubmed
    ..Thus, elastin has an unanticipated regulatory function during arterial development, controlling proliferation of smooth muscle and stabilizing arterial structure. ..
  2. Morita E, Sandrin V, Alam S, Eckert D, Gygi S, Sundquist W. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Cell Host Microbe. 2007;2:41-53 pubmed
    ..Taken together, these studies define the composition of human ESCRT-I complexes and indicate that the MVB12 subunits play a unique role in regulating ESCRT-mediated virus budding. ..
  3. Gates J, Thummel C. An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis. Genetics. 2000;156:1765-76 pubmed
    ..Both bancal and vulcan are inducible by ecdysone, thus linking the hormone signal with leg morphogenesis. This screen provides new directions for understanding the hormonal regulation of leg development during Drosophila metamorphosis. ..
  4. Kopinke D, Sasine J, Swift J, Stephens W, Piotrowski T. Retinoic acid is required for endodermal pouch morphogenesis and not for pharyngeal endoderm specification. Dev Dyn. 2006;235:2695-709 pubmed
    ..These results demonstrate that the developmental processes underlying pharyngeal arch defects differ depending on when RA signaling is disturbed during development...
  5. Clark K, Bland J, Beckerle M. The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci. 2007;120:2066-77 pubmed
  6. Chisaka O, Capecchi M. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature. 1991;350:473-9 pubmed
    ..In addition, they often feature defects of the heart and arteries as well as craniofacial abnormalities. These deficiencies are remarkably similar to the pathology of the human congenital disorder DiGeorge's syndrome. ..
  7. Hatch E, Noyes C, Wang X, Wright T, Mansour S. Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007;134:3615-25 pubmed
    ..Finally, we show that Fgf3 prevents ventral expansion of r5-6 neurectodermal Wnt3a, serving to focus inductive WNT signals on the dorsal otic vesicle and highlighting a new example of cross-talk between the two signaling systems. ..
  8. Jones T, Metzstein M. A novel function for the PAR complex in subcellular morphogenesis of tracheal terminal cells in Drosophila melanogaster. Genetics. 2011;189:153-64 pubmed publisher
    ..Our results demonstrate that proteins from the PAR complex can be deployed independently within a single cell to control two different morphogenetic processes. ..
  9. Jia S, Zhou J, Wee Y, Mikkola M, Schneider P, D Souza R. Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9-/- Mice. J Dent Res. 2017;96:1282-1289 pubmed publisher
  10. Jia S, Zhou J, Fanelli C, Wee Y, Bonds J, Schneider P, et al. Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero. Development. 2017;144:3819-3828 pubmed publisher
  11. Karow M, Georgopoulos C. Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB. J Bacteriol. 1992;174:702-10 pubmed
    ..These results suggest that MsbB and HtrB play an important role in outer membrane structure and/or function...
  12. Manley N, Capecchi M. The role of Hoxa-3 in mouse thymus and thyroid development. Development. 1995;121:1989-2003 pubmed
    ..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3. ..
  13. Urness L, Sorensen L, Li D. Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet. 2000;26:328-31 pubmed
    ..The early loss of anatomical, molecular and functional distinctions between arteries and veins indicates that Acvrl1 is required for developing distinct arterial and venous vascular beds. ..
  14. Chen F, Capecchi M. Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev Biol. 1997;181:186-96 pubmed
    ..In particular, the sternum defects are greatly exacerbated. Interestingly, the defects in hoxb-9 and hoxa-9/ hoxb-9 mutant mice are concentrated along the axial column at points of transition between vertebral types. ..
  15. D Avino P, Thummel C. crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis. Development. 1998;125:1733-45 pubmed
    ..The genetic criteria described here provide a new direction for identifying regulators of adult tissue development during insect metamorphosis. ..
  16. Dickinson W, Thatcher J. Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures. Cell Motil Cytoskeleton. 1997;38:9-21 pubmed
    ..We suggest that interactions between these and other actin-associated proteins are important in generating the diverse shapes of the cuticular specializations seen in both larvae and adults. ..
  17. Ohta S, Mansour S, Schoenwolf G. BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst. Dev Biol. 2010;347:369-81 pubmed publisher
  18. Cimbora D, Sakonju S. Drosophila midgut morphogenesis requires the function of the segmentation gene odd-paired. Dev Biol. 1995;169:580-95 pubmed
    ..abstract truncated at 400 words) ..
  19. Carpenter E, Goddard J, Chisaka O, Manley N, Capecchi M. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development. 1993;118:1063-75 pubmed
  20. Rabiger D, Drews G. MYB64 and MYB119 are required for cellularization and differentiation during female gametogenesis in Arabidopsis thaliana. PLoS Genet. 2013;9:e1003783 pubmed publisher
    ..Our data establish a molecular pathway regulating the FG5 transition and implicates CKI1-dependent TCS in the promotion of cellularization, differentiation, and gamete specification during female gametogenesis. ..
  21. Stachel S, Grunwald D, Myers P. Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish. Development. 1993;117:1261-74 pubmed
    ..Our results demonstrate that the zebrafish dorsal axis is signaled by a pathway initiated in the cleavage-stage embryo. Furthermore, they provide novel insights into anterior morphogenesis. ..
  22. Rogers S, Gahring L. Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy. PLoS ONE. 2012;7:e36467 pubmed publisher
    ..These results demonstrate distinct and varied spatiotemporal expression of alpha7 during tooth development, and they suggest that dysfunction of this receptor would have diverse impacts upon the adult organ. ..
  23. Karlstrom R, Wilder L, Bastiani M. Lachesin: an immunoglobulin superfamily protein whose expression correlates with neurogenesis in grasshopper embryos. Development. 1993;118:509-22 pubmed
    ..Lachesin is also similar to several other vertebrate immunoglobulin superfamily proteins (TAG-1, F11, L1 and NgCAM) known to function in neurite outgrowth and other cell surface recognition events. ..
  24. Aman A, Nguyen M, Piotrowski T. Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis. Dev Biol. 2011;349:470-82 pubmed publisher
  25. Kozlova T, Thummel C. Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science. 2003;301:1911-4 pubmed
    ..It also provides an intriguing parallel with the role of mammalian extraembryonic tissues as a critical source of steroid hormones during embryonic development. ..
  26. Aman A, Piotrowski T. Cell migration during morphogenesis. Dev Biol. 2010;341:20-33 pubmed publisher
    ..More importantly, we will highlight, compare and integrate recent advances in our understanding of how cell migration is regulated in these varied model systems with special emphasis on individual and collective cell movements. ..
  27. Arrington C, Yost H. Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo. Development. 2009;136:3143-52 pubmed publisher
  28. Hoshijima K, Metherall J, Grunwald D. A protein disulfide isomerase expressed in the embryonic midline is required for left/right asymmetries. Genes Dev. 2002;16:2518-29 pubmed
  29. Gaufo G, Thomas K, Capecchi M. Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons. Development. 2003;130:5191-201 pubmed
  30. Hutson L, Jurynec M, Yeo S, Okamoto H, Chien C. Two divergent slit1 genes in zebrafish. Dev Dyn. 2003;228:358-69 pubmed
    ..Their expression patterns, particularly that of slit1a, suggest that Slit proteins may have roles in tissue morphogenesis in addition to their established roles in axon guidance and cell migration. ..
  31. Willardsen M, Suli A, Pan Y, Marsh Armstrong N, Chien C, El Hodiri H, et al. Temporal regulation of Ath5 gene expression during eye development. Dev Biol. 2009;326:471-81 pubmed publisher
    ..This temporal regulation of Xath5 gene expression is comparable to proneural gene regulation in Drosophila, whereby separate enhancers regulate different temporal phases of expression. ..
  32. D Avino P, Thummel C. The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis. Dev Biol. 2000;220:211-24 pubmed
    ..We also propose that ecdysone modulation of integrin expression might be widely used to control multiple aspects of adult development. ..
  33. Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, et al. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest. 2008;118:2908-16 pubmed publisher
    ..Collectively, our results identify what we believe to be a novel complex involved in photoreceptor disk morphogenesis and indicate a possible role for PROM1 and PCDH21 in macular degeneration. ..
  34. Karnik S, Brooke B, Bayes Genis A, Sorensen L, Wythe J, Schwartz R, et al. A critical role for elastin signaling in vascular morphogenesis and disease. Development. 2003;130:411-23 pubmed
    ..Together, this work demonstrates that signaling pathways crucial for arterial morphogenesis can play an important role in the pathogenesis and treatment of vascular disease. ..
  35. Jones T, Nikolova L, Schjelderup A, Metzstein M. Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells. Dev Biol. 2014;390:41-50 pubmed publisher
    ..Together, our results suggest a model where exocyst mediated vesicle trafficking facilitates branch outgrowth, while de novo branching requires cooperation between the PAR and exocyst complexes. ..
  36. Park E, Ogden L, Talbot A, Evans S, Cai C, Black B, et al. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development. 2006;133:2419-33 pubmed
    ..These findings provide a novel insight into how the formation and remodeling of primary and anterior heart field-derived structures rely on Fgf8 signals from discrete temporospatial domains. ..
  37. Hill J, Demarest B, Gorsi B, Smith M, Yost H. Heart morphogenesis gene regulatory networks revealed by temporal expression analysis. Development. 2017;144:3487-3498 pubmed publisher
    ..This dataset provides an essential resource for future studies on the genetic/epigenetic pathways implicated in congenital heart defects and the mechanisms of cardiac transcriptional regulation. ..
  38. Ward R, Evans J, Thummel C. Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. Genetics. 2003;165:1397-415 pubmed
  39. Nishitani A, Ohta S, Yung A, Del Rio T, Gordon M, Abraira V, et al. Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis. Development. 2017;144:3349-3360 pubmed publisher
    ..These findings highlight the importance of apoptosis for tissue morphogenesis and suggest that Ntn1 may play divergent cellular roles despite its conserved expression during canal morphogenesis in chicken and mouse. ..