Experts and Doctors on ultraviolet rays in Dallas, Texas, United States


Locale: Dallas, Texas, United States
Topic: ultraviolet rays

Top Publications

  1. Lu W, Chapo J, Roig I, Abrams J. Meiotic recombination provokes functional activation of the p53 regulatory network. Science. 2010;328:1278-81 pubmed publisher
    ..Our findings establish a physiological role for p53 in meiosis and suggest that tumor-suppressive functions may have been co-opted from primordial activities linked to recombination. ..
  2. Bonkobara M, Yagihara H, Yudate T, Chung J, Washizu T, Ariizumi K, et al. Ultraviolet-B radiation upregulates expression of dectin-2 on epidermal Langerhans cells by activating the gene promoter. Photochem Photobiol. 2005;81:944-8 pubmed
    ..Such amplification suggests that UV-B-induced immunosuppression may be due (at least in part) to augmented dectin-2 expression in LC. ..
  3. Singh S, Yang K, Karthikeyan S, Huynh T, Zhang X, Phillips M, et al. The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. J Biol Chem. 2004;279:13166-73 pubmed
  4. Kaufman B, Newman S, Perlman P, Butow R. Crosslinking of proteins to mtDNA. Methods Mol Biol. 2002;197:377-89 pubmed
  5. Reis A, Cheo D, Meira L, Greenblatt M, Bond J, Nahari D, et al. Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin cancers in Xpc and Xpc Trp53 mutant mice. Cancer Res. 2000;60:1571-9 pubmed
    ..In Xpc-/- mice, the majority of mutations were located at C residues in CpG sites, in which the C is presumably methylated. A similar bias can be deduced from studies in human XP individuals. ..
  6. Gillette T, Huang W, Russell S, Reed S, Johnston S, Friedberg E. The 19S complex of the proteasome regulates nucleotide excision repair in yeast. Genes Dev. 2001;15:1528-39 pubmed
    ..The 19S regulatory complex of the yeast proteasome functions in nucleotide excision repair independent of proteolysis. ..
  7. Cheo D, Meira L, Hammer R, Burns D, Doughty A, Friedberg E. Synergistic interactions between XPC and p53 mutations in double-mutant mice: neural tube abnormalities and accelerated UV radiation-induced skin cancer. Curr Biol. 1996;6:1691-4 pubmed
    ..Additionally, we show that, following exposure to UV-B radiation, XPC p53 mutant mice have more severe solar keratosis and suffer accelerated skin cancer compared with XPC mutant mice that are wild-type with respect to p53. ..
  8. Nahari D, McDaniel L, Task L, Daniel R, Velasco Miguel S, Friedberg E. Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process. DNA Repair (Amst). 2004;3:379-86 pubmed
  9. Cheo D, Meira L, Burns D, Reis A, Issac T, Friedberg E. Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors. Cancer Res. 2000;60:1580-4 pubmed
    ..The Trp53 and Apex heterozygous conditions altered the skin tumor spectrum to more poorly differentiated forms in all Xpc genotypes. ..

More Information


  1. Bhatia P, Verhage R, Brouwer J, Friedberg E. Molecular cloning and characterization of Saccharomyces cerevisiae RAD28, the yeast homolog of the human Cockayne syndrome A (CSA) gene. J Bacteriol. 1996;178:5977-88 pubmed
    ..Both rad28 and rad26 null mutants are hypermutable following exposure to UV light. ..
  2. Raman M, Earnest S, Zhang K, Zhao Y, Cobb M. TAO kinases mediate activation of p38 in response to DNA damage. EMBO J. 2007;26:2005-14 pubmed
    ..These findings indicate that TAO kinases are regulators of p38-mediated responses to DNA damage and are intermediates in the activation of p38 by ATM. ..
  3. Cheo D, Ruven H, Meira L, Hammer R, Burns D, Tappe N, et al. Characterization of defective nucleotide excision repair in XPC mutant mice. Mutat Res. 1997;374:1-9 pubmed
    ..Mice defective in the XPC gene appear to be an excellent model for studying the role of NER and its interaction with other proteins in the molecular pathogenesis of cancer in mammals following exposure to environmental carcinogens. ..
  4. Feaver W, Huang W, Friedberg E. The TFB4 subunit of yeast TFIIH is required for both nucleotide excision repair and RNA polymerase II transcription. J Biol Chem. 1999;274:29564-7 pubmed
    ..These results indicate that like other subunits of TFIIH, Tfb4 is required for both RNA polymerase II transcription and DNA repair. ..
  5. Reed S, Akiyama M, Stillman B, Friedberg E. Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair. Genes Dev. 1999;13:3052-8 pubmed
    ..These studies define a novel and unexpected role for ABF1 protein during NER in yeast. ..
  6. Feaver W, Huang W, Gileadi O, Myers L, Gustafsson C, Kornberg R, et al. Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair. J Biol Chem. 2000;275:5941-6 pubmed
    ..These interactions have facilitated a more complete model of the structure of TFIIH and the nucleotide excision repairosome. ..
  7. Wang Z, Wei S, Reed S, Wu X, Svejstrup J, Feaver W, et al. The RAD7, RAD16, and RAD23 genes of Saccharomyces cerevisiae: requirement for transcription-independent nucleotide excision repair in vitro and interactions between the gene products. Mol Cell Biol. 1997;17:635-43 pubmed
    ..This process may involve a unique protein complex which is distinct from the repairosome and which contains at least the Rad4, Rad7, and Rad16 proteins. ..
  8. Gillette T, Yu S, Zhou Z, Waters R, Johnston S, Reed S. Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair. EMBO J. 2006;25:2529-38 pubmed
    ..These studies reveal that, following UV radiation, NER is mediated by nonproteolytic activities of the UPP, via the ubiquitin-like domain of Rad23 and UV radiation-induced ubiquitination of Rad4. ..
  9. Gavino A, Chung J, Sato K, Ariizumi K, Cruz P. Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. Exp Dermatol. 2005;14:281-8 pubmed
    ..Our findings may form the basis for understanding the function of human DECTIN-2 in innate immunity. ..
  10. Guo C, Tang T, Bienko M, Parker J, Bielen A, Sonoda E, et al. Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol. 2006;26:8892-900 pubmed
    ..In cells exposed to UV radiation, the association of REV1 with replication foci is dependent on functional UBMs. The UBMs of REV1 are shown to contribute to DNA damage tolerance and damage-induced mutagenesis in vivo. ..
  11. Yajima H, Lee K, Zhang S, Kobayashi J, Chen B. DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases. J Mol Biol. 2009;385:800-10 pubmed publisher
    ..These results suggest that the late increase of ATM activity is needed to complement the decreasing ATR activity for maintaining a vigilant checkpoint regulation upon replication stress. ..
  12. Tomihari M, Hwang S, Chung J, Cruz P, Ariizumi K. Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion. Exp Dermatol. 2009;18:586-95 pubmed publisher
    ..PAM212 keratinocytes adhered to immobilized Gpnmb in a RGD-dependent manner. These results indicate that Gpnmb is a melanosome-associated glycoprotein that contributes to the adhesion of melanocytes with keratinocytes. ..
  13. Russell S, Reed S, Huang W, Friedberg E, Johnston S. The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair. Mol Cell. 1999;3:687-95 pubmed
    ..Surprisingly, blockage of protein degradation by the proteasome has no effect on the efficiency of NER. This establishes that the regulatory complex of the proteasome has a function independent of protein degradation. ..
  14. Huang W, Feaver W, Tomkinson A, Friedberg E. The N-degron protein degradation strategy for investigating the function of essential genes: requirement for replication protein A and proliferating cell nuclear antigen proteins for nucleotide excision repair in yeast extracts. Mutat Res. 1998;408:183-94 pubmed
    ..We also demonstrate a physical interaction between RPA1 protein and subunits of the RNA polymerase II basal transcription factor IIH (TFIIH). ..
  15. Guo C, Tang T, Bienko M, Dikic I, Friedberg E. Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance. J Biol Chem. 2008;283:4658-64 pubmed
    ..However, the ubiquitin-binding motifs do not affect Polkappa half-life. Finally, we have examined levels of Polkappa expression following the exposure of mouse cells to benzo[a]pyrene-dihydrodiol epoxide or UVB radiation. ..
  16. Meira L, Cheo D, Reis A, Claij N, Burns D, te Riele H, et al. Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer. DNA Repair (Amst). 2002;1:929-34 pubmed
  17. Tong A, Nguyen J, Lynch K. Differential expression of CD45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons. J Biol Chem. 2005;280:38297-304 pubmed
    ..Together these studies reveal common themes in the regulation of the CD45 variable exons and provide a mechanistic explanation for the observed physiological expression of CD45 isoforms. ..
  18. Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, et al. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev. 2003;17:1475-86 pubmed
    ..The disappearance of Mcl-1 is also required for other mitochondrial apoptotic events including Bax translocation, cytochrome c release, and caspase activation. ..
  19. Harrod R, Nacsa J, Van Lint C, Hansen J, Karpova T, McNally J, et al. Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription. J Biol Chem. 2003;278:12310-8 pubmed
    ..Our results allude to a mechanism whereby the human immunodeficiency virus type-1 trans-activator might impair tumor suppressor functions in immune/neuronal-derived cells, thus favoring the establishment of neoplasia during AIDS. ..
  20. Hormi Carver K, Feagins L, Spechler S, Souza R. All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells. Am J Physiol Gastrointest Liver Physiol. 2007;292:G18-27 pubmed
    ..This study elucidates molecular pathways whereby retinoid treatment might prevent carcinogenesis in Barrett's metaplasia and suggests a potential role for the use of safer retinoids for chemoprevention in Barrett's esophagus. ..
  21. Sung H, Yeamans G, Ross C, Yasbin R. Roles of YqjH and YqjW, homologs of the Escherichia coli UmuC/DinB or Y superfamily of DNA polymerases, in stationary-phase mutagenesis and UV-induced mutagenesis of Bacillus subtilis. J Bacteriol. 2003;185:2153-60 pubmed
    ..subtilis to generate revertants at the hisC952 allele via this system. These data suggest a role for YqjH in the generation of at least some types of stationary-phase-induced mutagenesis. ..
  22. Glazer C, Martyny J, Lee B, Sanchez T, Sells T, Newman L, et al. Nontuberculous mycobacteria in aerosol droplets and bulk water samples from therapy pools and hot tubs. J Occup Environ Hyg. 2007;4:831-40 pubmed
    ..02-0.03). These findings suggest that NTM are frequently detectable in the air and water of spas and therapy pools and that particular maintenance and disinfection approaches affect NTM bioaerosol concentrations in these settings. ..
  23. Frederick G, Amirkhan R, Schultz R, Friedberg E. Structural and mutational analysis of the xeroderma pigmentosum group D (XPD) gene. Hum Mol Genet. 1994;3:1783-8 pubmed
    ..These results confirm the role of ERCC2 in XP-D and illustrate the power of utilizing cellular phenotypes to evaluate the significance of single nucleotide substitutions. ..
  24. Zhang H, Zhang X, Chen X, Thomas D, Hormi Carver K, Elder F, et al. Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus. Am J Physiol Gastrointest Liver Physiol. 2008;295:G470-8 pubmed publisher
    ..We speculate that these differences might underlie the development of Barrett's metaplasia. ..
  25. Meira L, Graham J, Greenberg C, Busch D, Doughty A, Ziffer D, et al. Manitoba aboriginal kindred with original cerebro-oculo- facio-skeletal syndrome has a mutation in the Cockayne syndrome group B (CSB) gene. Am J Hum Genet. 2000;66:1221-8 pubmed
    ..This mutation was also detected in three other patients with COFS syndrome from the Manitoba Aboriginal population group. These results suggest that CS and COFS syndrome share a common pathogenesis. ..
  26. Wang Z, Buratowski S, Svejstrup J, Feaver W, Wu X, Kornberg R, et al. The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair and RNA polymerase II transcription. Mol Cell Biol. 1995;15:2288-93 pubmed
    ..Our results also suggest that the repair and transcription functions of Tfb1 and Ssl1 are separable. ..