Experts and Doctors on th1 cells in Dallas, Texas, United States


Locale: Dallas, Texas, United States
Topic: th1 cells

Top Publications

  1. Klechevsky E, Kato H, Sponaas A. Dendritic cells star in Vancouver. J Exp Med. 2005;202:5-10 pubmed
    ..New insights into the molecular mechanisms of DC function and their influence on immune regulation, their role in infectious and autoimmune disease, and new clinical applications are highlighted. ..
  2. Cravens P, Kieseier B, Hussain R, Herndon E, Arellano B, Ben L, et al. The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis. J Neuroinflammation. 2013;10:67 pubmed publisher
    ..In contrast, IL-17 transcripts could not be detected in adult or neonate CNS in this EAE model, and neither adult nor neonate donor CD4+ T cells expressed IL-17 at the time of adoptive transfer. ..
  3. Matsue H, Edelbaum D, Shalhevet D, Mizumoto N, Yang C, Mummert M, et al. Generation and function of reactive oxygen species in dendritic cells during antigen presentation. J Immunol. 2003;171:3010-8 pubmed
  4. Persky M, Murphy K, Farrar J. IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene. J Immunol. 2005;174:294-301 pubmed
  5. Gocke A, Cravens P, Ben L, Hussain R, Northrop S, Racke M, et al. T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J Immunol. 2007;178:1341-8 pubmed
    ..We now show for the first time that suppression of T-bet ameliorates EAE by limiting the differentiation of autoreactive Th1 cells, as well as inhibiting pathogenic Th17 cells via regulation of IL-23R. ..
  6. Davis A, RAMOS H, Davis L, Farrar J. Cutting edge: a T-bet-independent role for IFN-alpha/beta in regulating IL-2 secretion in human CD4+ central memory T cells. J Immunol. 2008;181:8204-8 pubmed
    ..Thus, our results highlight a unique role for IFN-alpha in regulating the development of IL-2-secreting human T(CM) cells. ..
  7. Niederkorn J, Chen P, Mellon J, Stevens C, Mayhew E. Allergic conjunctivitis exacerbates corneal allograft rejection by activating Th1 and th2 alloimmune responses. J Immunol. 2010;184:6076-83 pubmed publisher
    ..Thus, exacerbation of corneal allograft rejection in mice with AC is associated with a mixed Th1 and Th2 alloimmune response, and the contribution of Th1 cells is through their production of IFN-gamma...
  8. Lambracht Washington D, Qu B, Fu M, Anderson L, Stuve O, Eagar T, et al. DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation. Cell Mol Neurobiol. 2011;31:867-74 pubmed publisher
    ..Therefore, A?42 DNA trimer immunization has a high probability to be effective and safe to treat patients with early AD. ..
  9. Morita R, Schmitt N, Bentebibel S, Ranganathan R, Bourdery L, Zurawski G, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011;34:108-21 pubmed publisher
    ..Importantly, the skewing of subsets correlated with disease activity and frequency of blood plasmablasts. Collectively, our study suggests that an altered balance of Tfh cell subsets contributes to human autoimmunity. ..

More Information


  1. Chujo D, Foucat E, Nguyen T, Chaussabel D, Banchereau J, Ueno H. ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adults. PLoS ONE. 2013;8:e55595 pubmed publisher
    ..This strategy is applicable to determine the differences in the quality of antigen-specific T cells between health and disease. ..
  2. Trueba A, Ritz T. Stress, asthma, and respiratory infections: pathways involving airway immunology and microbial endocrinology. Brain Behav Immun. 2013;29:11-27 pubmed publisher
    ..In addition, we review findings suggesting that psychological stress not only modulates immune processes, but also the pathogenic qualities of bacteria, with implications for the pathogenesis and exacerbation asthma. ..
  3. Benson A, Murray S, Divakar P, Burnaevskiy N, Pifer R, Forman J, et al. Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism. J Immunol. 2012;188:800-10 pubmed publisher
    ..These results demonstrate that the transient reduction in Treg cells induced by pathogens via IL-2 deprivation is essential for optimal T cell responses and host resistance to microbial and viral pathogens. ..
  4. Milush J, Mir K, Sundaravaradan V, Gordon S, Engram J, Cano C, et al. Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells. J Clin Invest. 2011;121:1102-10 pubmed publisher
  5. Lambracht Washington D, Qu B, Fu M, Eagar T, Stuve O, Rosenberg R. DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model. JAMA. 2009;302:1796-802 pubmed publisher
    ..03). In this preliminary study in a wild-type mouse model, DNA Abeta42 trimer immunization protocol produced a T(H)2 immune response and appeared to have low potential to cause an inflammatory T-cell response. ..
  6. Pifer R, Benson A, Sturge C, Yarovinsky F. UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J Biol Chem. 2011;286:3307-14 pubmed publisher
    ..gondii profilin and for host protection against this parasite. ..
  7. Raetz M, Hwang S, Wilhelm C, Kirkland D, Benson A, Sturge C, et al. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells. Nat Immunol. 2013;14:136-42 pubmed publisher
    ..gondii infection identified the T cell-intrinsic TLR pathway as a major regulator of IFN-? production in CD4(+) T cells responsible for Paneth cell death, dysbiosis and intestinal immunopathology...
  8. RAMOS H, Davis A, George T, Farrar J. IFN-alpha is not sufficient to drive Th1 development due to lack of stable T-bet expression. J Immunol. 2007;179:3792-803 pubmed
    ..These results indicate that IL-12 remains unique in its ability to drive Th1 development in human CD4+ T cells and that IFN-alpha lacks this activity due to its inability to promote sustained T-bet expression. ..
  9. Liu H, Li B, Jia X, Ma Y, Gu Y, Zhang P, et al. Radiation-induced decrease of CD8+ dendritic cells contributes to Th1/Th2 shift. Int Immunopharmacol. 2017;46:178-185 pubmed publisher
    ..In conclusion, our data showed that IR induced a decrease of CD8+DC and Th1/Th2 shift, which was reversed by Flt3 ligand treatment, suggesting a novel mechanism for radiation-induced immunosuppression. ..