Experts and Doctors on tetradecanoylphorbol acetate in Houston, Texas, United States


Locale: Houston, Texas, United States
Topic: tetradecanoylphorbol acetate

Top Publications

  1. Sriraman V, Richards J. Cathepsin L gene expression and promoter activation in rodent granulosa cells. Endocrinology. 2004;145:582-91 pubmed
  2. Russell D, Ochsner S, Hsieh M, Mulders S, Richards J. Hormone-regulated expression and localization of versican in the rodent ovary. Endocrinology. 2003;144:1020-31 pubmed
    ..These observations suggest that versican (V0, V1, and V3) is a matrix component of the granulosa layer throughout folliculogenesis and is enriched in remodeling matrices during ovulation and neovascularization of the corpora lutea. ..
  3. Rodriguez Villanueva J, Greenhalgh D, Wang X, Bundman D, Cho S, Delehedde M, et al. Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation. Oncogene. 1998;16:853-63 pubmed
    ..bcl-2 mice compared to control littermates following initiation with DMBA and promotion with TPA. Together these results support a role for bcl-2 in the pathogenesis of NMSC. ..
  4. Yakubu M, Nsaif R, Oyekan A. Regulation of cerebrovascular endothelial peroxisome proliferator activator receptor alpha expression and nitric oxide production by clofibrate. Bratisl Lek Listy. 2010;111:258-64 pubmed
  5. Honeycutt K, Waikel R, Koster M, Wang X, Roop D. The effect of c-myc on stem cell fate influences skin tumor phenotype. Mol Carcinog. 2010;49:315-9 pubmed publisher
    ..Our data demonstrate that genetic alterations that alter the fate of multipotent stem cells during embryonic development can markedly influence the phenotype of NMSC that develop following exposure to carcinogens...
  6. Manna S, Aggarwal B. Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis. J Immunol. 2000;164:5156-66 pubmed
    ..Overall, our results demonstrate that p56lck plays a critical role in the activation of NF-kappa B, AP-1, JNK, and apoptosis by HIV-tat protein but has minimal or no role in activation of these responses by TNF. ..
  7. Lee Y, Choi Y, Chua S, Park Y, Moore D. Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem. 2006;281:7850-5 pubmed
    ..This pathway may contribute to recently described proliferative functions of LRH-1. ..
  8. Go C, He W, Zhong L, Li P, Huang J, Brinkley B, et al. Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII. Oncogene. 2000;19:3623-31 pubmed
    ..These data indicate that inactivation of TGFbetaRII accelerates skin tumorigenesis at early stages by the acceleration of loss of cell cycle control, but not by increased chromosome instability. ..
  9. Al Bagdadi F, Singh B, Arlinghaus R. Evidence for involvement of the protein kinase C pathway in the activation of p37v-mos protein kinase. Oncogene. 1990;5:1251-7 pubmed
    ..These findings indicate that the protein kinase C pathway but not the protein kinase A pathway modulates v-mos protein kinase activity. ..

More Information


  1. Bhattacharya A, Lakka S, Mohanam S, Boyd D, Rao J. Regulation of the urokinase-type plasminogen activator receptor gene in different grades of human glioma cell lines. Clin Cancer Res. 2001;7:267-76 pubmed
    ..We conclude from our findings that increased transcription is the more likely mechanism underlying the increase in uPAR production in high-grade gliomas. ..
  2. Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan T, et al. Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. Oncogene. 2001;20:1703-14 pubmed
    ..Therefore, our data suggest that the hematopoietic specific proteins Grap2 and HPK1 form a signaling complex to mediate the c-Jun NH(2)-terminal kinase (JNK) signaling pathway in T cells. ..
  3. Elberg G, Hipkin R, Schonbrunn A. Homologous and heterologous regulation of somatostatin receptor 2. Mol Endocrinol. 2002;16:2502-14 pubmed
    ..In addition, the heterologous hormones also modulate sst2 receptor internalization by a novel mechanism that is independent of receptor phosphorylation. ..
  4. Goicoechea S, Garcia Mata R, Staub J, Valdivia A, Sharek L, McCulloch C, et al. Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. Oncogene. 2014;33:1265-73 pubmed publisher
    ..Together, these results identify a novel molecular signaling pathway that may provide new molecular targets for the inhibition of pancreatic cancer metastasis. ..
  5. Liu Q, Bee M, Schonbrunn A. Site specificity of agonist and second messenger-activated kinases for somatostatin receptor subtype 2A (Sst2A) phosphorylation. Mol Pharmacol. 2009;76:68-80 pubmed publisher
  6. Gao X, Wu L, O Neil R. Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J Biol Chem. 2003;278:27129-37 pubmed
    ..The convergence of multiple signals and transduction pathways on the same channel indicate that the channel functions as a molecular integrator of microenvironmental chemical and physical signals...
  7. Guan B, Yue P, Lotan R, Sun S. Evidence that the human death receptor 4 is regulated by activator protein 1. Oncogene. 2002;21:3121-9 pubmed
    ..Therefore, our findings may increase the understanding of the mechanisms underlying AP-1-mediated apoptosis as well as drug-induced apoptosis. ..
  8. Natraj U, Richards J. Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory follicles. Endocrinology. 1993;133:761-9 pubmed
  9. Saunders M, Sansores Garcia L, Gilroy D, Wu K. Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. J Biol Chem. 2001;276:18897-904 pubmed
    ..These findings have a major impact on the conceptual understanding of the mechanism of action of salicylates and on new drug discovery and design. ..
  10. Sharma S, Richards J. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. J Biol Chem. 2000;275:33718-28 pubmed
  11. Wang X, Greenhalgh D, Donehower L, Roop D. Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis. Mol Carcinog. 2000;29:67-75 pubmed
    ..Because neither spontaneous nor TPA-elicited papillomas in p53(-/-) mice progressed to malignancy, additional genetic insults appear to be required for malignant progression. ..
  12. Shin M, Yan C, Boyd D. An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression. Biochim Biophys Acta. 2002;1589:311-6 pubmed
    ..These findings indicate the efficacy of SP600125 in inhibiting c-Jun activation, DNA-binding and the PMA-dependent induction of MMP-9 expression. ..
  13. Bhave G, Hu H, Glauner K, Zhu W, Wang H, Brasier D, et al. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A. 2003;100:12480-5 pubmed
    ..Furthermore, modulation of the TRPV1 function by PKC appears to involve distinct phosphorylation sites depending on the mechanism of channel activation. ..
  14. Russell D, Doyle K, Gonzales Robayna I, Pipaon C, Richards J. Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1, and. Mol Endocrinol. 2003;17:520-33 pubmed
    ..These observations indicate that the Egr-1 gene is a target of both FSH and LH action that may mediate molecular programs of proliferation and/or differentiation during follicle growth, ovulation, and luteinization. ..
  15. Mandyam C, Thakker D, Christensen J, Standifer K. Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther. 2002;302:502-9 pubmed
    ..Our results demonstrate for the first time the involvement of conventional PKC isozymes in OFQ/N-induced mu-ORL1 cross-talk, and represent a possible mechanism for OFQ/N-induced anti-opioid actions. ..
  16. Yan C, Wang H, Boyd D. KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Balpha -induced block of p65/p50 nuclear translocation. J Biol Chem. 2001;276:1164-72 pubmed
    ..Thus, KiSS-1 diminishes MMP-9 expression by effecting reduced NF-kappaB binding to the promoter. ..
  17. Liou J, Deng W, Gilroy D, Shyue S, Wu K. Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts. J Biol Chem. 2001;276:34975-82 pubmed
    ..Because caveolae are rich in signaling molecules, this COX-2 compartment may play an important role in diverse pathophysiological processes. ..
  18. Grindel B, Rohe B, Safford S, Bennett J, Farach Carson M. Tumor necrosis factor-α treatment of HepG2 cells mobilizes a cytoplasmic pool of ERp57/1,25D₃-MARRS to the nucleus. J Cell Biochem. 2011;112:2606-15 pubmed publisher
    ..Immunostaining for both ERp57-GFP and p65 after TNF-α treatment indicated that nuclear translocation of these two proteins occurs independently in HepG2 cells. ..
  19. Du M, Sansores Garcia L, Zu Z, Wu K. Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family. J Biol Chem. 1998;273:24289-92 pubmed
    ..Hs-CUL-3 widely expressed in human tissues and its expression in cultured COLO205 colon cancer cells was increased when compared with that in normal colon cells. It is likely that Hs-CUL-3 is involved in cell proliferation control. ..
  20. Wang X, Liefer K, Tsai S, O Malley B, Roop D. Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis. Proc Natl Acad Sci U S A. 1999;96:8483-8 pubmed
    ..Given that the TGFbeta1 transgene can affect both the epidermis and dermis, this transgenic model will provide a useful tool for studying roles of TGFbeta1 in wound-healing and skin carcinogenesis in the future. ..
  21. Wang X, Liefer K, Greenhalgh D, Roop D. 12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation. Mol Carcinog. 1999;26:305-11 pubmed
    ..However, in this transgenic model conversion always required additional genetic events, e.g., activation of the endogenous c-Ha-ras gene. ..
  22. Tahara E, Kadara H, Lacroix L, Lotan D, Lotan R. Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction. Cancer Biol Ther. 2009;8:801-7 pubmed
    ..Our results demonstrate the induction of the tumor suppressor KLF6 following PKC activation and its importance for PMA-mediated cancer cell growth arrest. ..
  23. Ward P, Mendoza Meneses M, Park P, Conneely O. Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice. Am J Pathol. 2008;172:1019-29 pubmed publisher
    ..Taken together, these results indicate that although LF deficiency alone is not a primary cause of the defects associated with SGD, this protein does play an immunomodulatory role in the oxidative burst response of neutrophils. ..
  24. Long D, Waikel R, Wang X, Perlaky L, Roop D, Jaiswal A. NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis. Cancer Res. 2000;60:5913-5 pubmed
    ..Histological analysis of the NQO1-/- tumors showed proliferative activity. These results demonstrate that NQO1 acts as an endogenous factor in protection against benzo(a)pyrene carcinogenicity. ..
  25. DeNardo D, Kim H, Hilsenbeck S, Cuba V, Tsimelzon A, Brown P. Global gene expression analysis of estrogen receptor transcription factor cross talk in breast cancer: identification of estrogen-induced/activator protein-1-dependent genes. Mol Endocrinol. 2005;19:362-78 pubmed
    ..These studies demonstrate that microarrays can be used in a reverse genetics approach to predict the functional promoter structure of large numbers of genes that are regulated by multiple transcription factors. ..
  26. Wu H, Rodgers J, Perrard X, Perrard J, Prince J, Abe Y, et al. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004;173:297-306 pubmed
  27. Foskett S, Ghose R, Tang D, Lewis D, Rice A. Antiapoptotic function of Cdk9 (TAK/P-TEFb) in U937 promonocytic cells. J Virol. 2001;75:1220-8 pubmed
    ..Because Cdk9 function is induced in PMA-treated U937 cells, Cdk9 may play an antiapoptotic role during monocyte differentiation. ..
  28. Honeycutt K, Chen Z, Koster M, Miers M, Nuchtern J, Hicks J, et al. Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Oncogene. 2006;25:4027-32 pubmed
    ..MCM7 mice. Whereas previous studies have shown that MCM7 is useful as a proliferation marker, our data suggest that deregulated MCM7 expression actively contributes to tumor formation, progression and malignant conversion. ..
  29. Sriraman V, Rudd M, Lohmann S, Mulders S, Richards J. Cyclic guanosine 5'-monophosphate-dependent protein kinase II is induced by luteinizing hormone and progesterone receptor-dependent mechanisms in granulosa cells and cumulus oocyte complexes of ovulating follicles. Mol Endocrinol. 2006;20:348-61 pubmed
  30. Iskander K, Gaikwad A, Paquet M, Long D, Brayton C, Barrios R, et al. Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. 2005;65:2054-8 pubmed
  31. Deng W, Zhu Y, Wu K. Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood. 2004;103:2135-42 pubmed
    ..We conclude that p300 is the predominant coactivator that is essential for COX-2 transcriptional activation by proinflammatory mediators. ..
  32. Adachi R, Krilis S, Nigrovic P, Hamilton M, Chung K, Thakurdas S, et al. Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. J Biol Chem. 2012;287:20047-55 pubmed publisher
    ..The latter findings raise the possibility that the pharmacologic inactivation of this intracellular signaling protein might be an effective treatment for arthritis or inflammatory bowel disease. ..