Genomes and Genes
Experts and Doctors on repressor proteins in Houston, Texas, United States
Locale: Houston, Texas, United States
Topic: repressor proteins
Publications311 found, 100 shown here
- Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, et al. SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene. 2017;36:4767-4777 pubmed publisher..We propose SPOPMT-induced stabilization of c-MYC protein as a novel mechanism that can increase total c-MYC levels in PC cells, in addition to amplification of c-MYC locus. ..
- Pflughoeft K, Sumby P, Koehler T. Bacillus anthracis sin locus and regulation of secreted proteases. J Bacteriol. 2011;193:631-9 pubmed publisher..Our data are consistent with a model in which InhA1 protease levels are controlled at the transcriptional level by SinR and at the posttranslational level by camelysin...
- Beckstead R, Ortiz J, Sanchez C, Prokopenko S, Chambon P, Losson R, et al. Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription. Mol Cell. 2001;7:753-65 pubmed..Bon binds via an LxxLL motif to the AF-2 activation domain present in the ligand binding domain of betaFTZ-F1 and behaves as a transcriptional inhibitor in vivo. ..
- Zheng J, Zhou Y, Maity T, Liao W, Saunders G. Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1. Nucleic Acids Res. 2001;29:4070-8 pubmed..Data from immunoprecipitation and transient transfection assays demonstrated that SEF and Sp1 interacted in vitro and may act together in vivo to regulate PAX6 expression. ..
- Shalel Levanon S, San K, Bennett G. Effect of oxygen, and ArcA and FNR regulators on the expression of genes related to the electron transfer chain and the TCA cycle in Escherichia coli. Metab Eng. 2005;7:364-74 pubmed
- Huang Z, Li J, Wong J. AR possesses an intrinsic hormone-independent transcriptional activity. Mol Endocrinol. 2002;16:924-37 pubmed..Altogether, our studies reveal that AR has a capacity to activate transcription in a ligand-independent manner. ..
- Medrano E. Repression of TGF-beta signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasis. Oncogene. 2003;22:3123-9 pubmed..Here, I discuss the basis for repression of intracellular TGF-beta signaling by SKI, some additional activities of this protein, and propose that by disrupting multiple tumor suppressor pathways, SKI functions as a melanoma oncogene. ..
- Banko J, Poulin F, Hou L, DeMaria C, Sonenberg N, Klann E. The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci. 2005;25:9581-90 pubmed..These results suggest a crucial role for proper regulation of the eIF4F complex by 4E-BP2 during LTP and learning and memory in the mouse hippocampus. ..
- Adams M, Wang B, Xia Z, Morales J, Lu X, Donehower L, et al. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle. 2005;4:1854-61 pubmed..Lastly, we find that deficiencies in 53BP1 generate a "hyper-rec" phenotype. Collectively, these data provide new insight into 53BP1, an important component in maintaining genomic stability. ..
- Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang F, Fuller G, et al. Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol. 2006;26:1666-78 pubmed..Furthermore, these results suggest that such a mechanism plays a role in the formation of human medulloblastoma. ..
- Schumacher M, Seidel G, Hillen W, Brennan R. Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate. J Mol Biol. 2007;368:1042-50 pubmed
- Erez A, Li J, Geraghty M, Ben Shachar S, Cooper M, Mensing D, et al. Mosaic deletion 11p13 in a child with dopamine beta-hydroxylase deficiency--case report and review of the literature. Am J Med Genet A. 2010;152A:732-6 pubmed publisher..Finally, it demonstrates the possible phenotypic effects of low-level PAX6 haploinsufficiency in a dosage-sensitive manner. ..
- Townson S, Dobrzycka K, Lee A, Air M, Deng W, Kang K, et al. SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. J Biol Chem. 2003;278:20059-68 pubmed..Our findings suggest that evolutionary duplication of the SAFB gene has allowed it to retain crucial functions, but also to gain novel functions in the cytoplasm and/or nucleus. ..
- Gajewski K, Kim Y, Lee Y, Olson E, Schulz R. D-mef2 is a target for Tinman activation during Drosophila heart development. EMBO J. 1997;16:515-22 pubmed..These results define the only known in vivo target for transcriptional activation by Tinman and demonstrate that D-mef2 lies directly downstream of tinman in the genetic cascade controlling heart formation in Drosophila. ..
- Edwards M, Liegeois N, Horecka J, DePinho R, Sprague G, Tyers M, et al. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Genetics. 1997;147:1063-76 pubmed..Moreover, several of the yeast OPY genes have overlapping functions with the human CPR genes, indicating a possible conservation of roles. ..
- Schulz R, Gajewski K. Ventral neuroblasts and the heartless FGF receptor are required for muscle founder cell specification in Drosophila. Oncogene. 1999;18:6818-23 pubmed..These results suggest the use of a neuroectoderm-to-mesoderm signaling pathway in the specification of ventral muscle precursors. ..
- Heilstedt H, Shahbazian M, Lee B. Infantile hypotonia as a presentation of Rett syndrome. Am J Med Genet. 2002;111:238-42 pubmed..Furthermore, it supports the hypothesis of an underlying secondary defect in energy metabolism contributing to the pathogenesis of RTT. ..
- Boonyaratanakornkit V. Scaffolding proteins mediating membrane-initiated extra-nuclear actions of estrogen receptor. Steroids. 2011;76:877-84 pubmed publisher..Future studies defining physiological roles of ER extra-nuclear actions and crosstalk with its nuclear counterparts will be important to our overall understanding of estrogen and ER biological functions. ..
- Timchenko N, Welm A, Lu X, Timchenko L. CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms. Nucleic Acids Res. 1999;27:4517-25 pubmed..Our data demonstrate that CUGBP1 protein is an important component for the regulation of initiation from different AUG codons of C/EBPbeta mRNA. ..
- Oh J, Kaplan S. Redox signaling: globalization of gene expression. EMBO J. 2000;19:4237-47 pubmed..Together, these interacting regulatory circuits are depicted in a model that permits us to understand the regulation by oxygen and light of photosynthesis gene expression in R.SPHAEROIDES: ..
- Zeng J, Kirk B, Gou Y, Wang Q, Ma J. Genome-wide polycomb target gene prediction in Drosophila melanogaster. Nucleic Acids Res. 2012;40:5848-63 pubmed publisher..From a computational standpoint, our strategy of modelling transcription factor interaction with a non-linear kernel is original, effective and transferable to many other applications. ..
- Lin S, Elledge S. Multiple tumor suppressor pathways negatively regulate telomerase. Cell. 2003;113:881-9 pubmed..These studies suggest that multiple tumor suppressor/oncogene pathways coordinately repress hTERT expression and imply that telomerase is reactivated in human tumors through oncogenic mutations. ..
- Zhu J, Shalel Levanon S, Bennett G, San K. Effect of the global redox sensing/regulation networks on Escherichia coli and metabolic flux distribution based on C-13 labeling experiments. Metab Eng. 2006;8:619-27 pubmed..7, 364-374]). The significantly higher lactate production in the arcAfnr double mutant strain was shown to be an indirect effect caused by the reduced pyruvate formate-lyase (PFL) and PDH fluxes as well as the intracellular redox state. ..
- Visvanathan J, Lee S, Lee B, Lee J, Lee S. The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev. 2007;21:744-9 pubmed..Our results suggest that, during CNS development, timely down-regulation of SCP1 is critical for inducing neurogenesis, and miR-124 contributes to this process at least in part by down-regulating SCP1 expression. ..
- Lindsay E, Harvey E, Scambler P, Baldini A. ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene. Hum Mol Genet. 1998;7:629-35 pubmed..This finding suggests that different genes in the deleted region may be functionally related and might explain the occurrence of the characteristic phenotype in patients with non-overlapping genetic lesions. ..
- Chinen J, Badran Y, Geha R, Chou J, Fried A. Advances in basic and clinical immunology in 2016. J Allergy Clin Immunol. 2017;140:959-973 pubmed publisher..Development of vaccines for HIV infection continues to provide insight into the immune response against a virus with an extraordinary mutation rate. ..
- Jafar Nejad H, Acar M, Nolo R, Lacin H, Pan H, Parkhurst S, et al. Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 2003;17:2966-78 pubmed..In the presumptive SOPs that express high levels of Sens, it acts as a transcriptional activator and synergizes with proneural proteins. We therefore propose that Sens acts as a binary switch that is fundamental to SOP selection...
- Zhang D, Yoon H, Wong J. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). Mol Cell Biol. 2005;25:6404-14 pubmed..Our data indicate that JMJD2A makes use of the N-CoR complex to repress transcription and suggest that JMJD2A together with N-CoR could play a role in repressing ASCL2 expression in various tissues. ..
- Fu J, Qin L, He T, Qin J, Hong J, Wong J, et al. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res. 2011;21:275-89 pubmed publisher..These findings not only provide novel mechanistic and functional links between TWIST and the Mi2/NuRD complex but also establish new essential roles for the components of Mi2/NuRD complex in cancer metastasis. ..
- Zage P, Nolo R, Fang W, Stewart J, Garcia Manero G, Zweidler McKay P. Notch pathway activation induces neuroblastoma tumor cell growth arrest. Pediatr Blood Cancer. 2012;58:682-9 pubmed publisher..HES gene expression appears to be regulated epigenetically and could be induced with decitabine. These findings support a tumor suppressor role for Notch signaling in neuroblastoma. ..
- Nguyen T, Cho K, Stratton S, Barton M. Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene. Mol Cell Biol. 2005;25:2147-57 pubmed..p53-null mice exhibit developmentally delayed AFP repression, concomitant with acetylation of H3K9, methylation of H3K4, and loss of DiMetH3K9, mSin3A/HDAC1, and HP1 interactions. ..
- Wilson C, Zhan H, Swint Kruse L, Matthews K. The lactose repressor system: paradigms for regulation, allosteric behavior and protein folding. Cell Mol Life Sci. 2007;64:3-16 pubmed..Thus, the lac system continues to advance our molecular understanding of genetic control and the relationship between sequence, structure and function. ..
- Brooks B, Piro K, Brennan R. Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions. J Am Chem Soc. 2007;129:8389-95 pubmed..Chemical redundancy is likely a hallmark of all multidrug-binding pockets, yet it is utilized by only a subset of drugs, which, for QacR, so far appears to be limited to chemically rigid, bivalent compounds. ..
- Horstmann N, Sahasrabhojane P, Suber B, Kumaraswami M, Olsen R, FLORES A, et al. Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. PLoS Pathog. 2011;7:e1002311 pubmed publisher..Taken together, these data provide structural and functional insights into the critical and distinct effects of variation in the CovR protein on GAS pathogenesis. ..
- Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, et al. Genome Organization Drives Chromosome Fragility. Cell. 2017;170:507-521.e18 pubmed publisher..Thus, loop anchors serve as fragile sites that generate DSBs and chromosomal rearrangements. VIDEO ABSTRACT. ..
- Morrison A, Sardet C, Herrera R. Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome. Mol Cell Biol. 2002;22:856-65 pubmed..Thus, the repressive role of pRb in cyclin E transcription and therefore cell cycle progression can be mapped to its control of the acetylation status and conformation of a single nucleosome. ..
- Zuo X, Morris J, Broaddus R, Shureiqi I. 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells. Oncogene. 2009;28:1496-505 pubmed publisher..Thus, our results show that NuRD contributes to 15-LOX-1 transcription suppression in colon cancer cells and that HDACIs can inhibit NuRD recruitment to a promoter to activate gene transcription, as in the case of 15-LOX-1. ..
- Li Z, Burzawa J, Troung A, Feng S, Agoulnik I, Tong X, et al. Relaxin signaling in uterine fibroids. Ann N Y Acad Sci. 2009;1160:374-8 pubmed publisher..Relaxin or insulin-like peptide 3 treatment suppressed transforming growth factor beta-induced phosphorylation of SMAD2 in rat leiomyoma ELT-3 cells in vitro, suggesting a possible involvement of relaxins in the etiology of leiomyoma. ..
- Hong J, Park J, Lee M, Mu oz W, Miller R, Ji H, et al. Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway. J Cell Sci. 2012;125:561-9 pubmed publisher..Conceivably, this work might also prove relevant to understanding the contribution of Dyrk1A dosage imbalance in Down's syndrome...
- Taylor P, Fangusaro J, Rajaram V, Goldman S, Helenowski I, Macdonald T, et al. REST is a novel prognostic factor and therapeutic target for medulloblastoma. Mol Cancer Ther. 2012;11:1713-1723 pubmed publisher..A REST-dependent decrease in cell growth was also observed following SAHA treatment. Thus, our studies suggest that HDACIs may have therapeutic potential for patients with REST-positive tumors. This warrants further investigation. ..
- Babcock B, Anderson B, Papayannopoulos I, Castilleja A, Murray J, Stifani S, et al. Ovarian and breast cytotoxic T lymphocytes can recognize peptides from the amino enhancer of split protein of the Notch complex. Mol Immunol. 1998;35:1121-33 pubmed
- Gajewski K, Zhang Q, Choi C, Fossett N, Dang A, Kim Y, et al. Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis. Dev Biol. 2001;233:425-36 pubmed..Together, these results provide important insights into the genetic mechanisms controlling heart formation in the Drosophila model system. ..
- Mo W, Liu Q, Lin C, Dai H, Peng Y, Liang Y, et al. mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer. Clin Cancer Res. 2016;22:1699-712 pubmed publisher..Collectively, these findings strongly suggest that combining mTOR inhibitors and PARP inhibitors would be an effective therapeutic approach to treat BRCA-proficient TNBC patients. ..
- Zhou Y, Zheng J, Gu X, Li W, Saunders G. A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?. Gene. 2000;245:319-28 pubmed
- Rogg L, Lasswell J, Bartel B. A gain-of-function mutation in IAA28 suppresses lateral root development. Plant Cell. 2001;13:465-80 pubmed..Studies of the gain-of-function iaa28-1 mutant suggest that IAA28 normally represses transcription, perhaps of genes that promote lateral root initiation in response to auxin signals. ..
- Gupta A, Kone B. USF-1 and USF-2 trans-repress IL-1beta-induced iNOS transcription in mesangial cells. Am J Physiol Cell Physiol. 2002;283:C1065-72 pubmed..These results demonstrated that USF binding to the E-box at -893/-888 serves to trans-repress basal expression and IL-1beta induction of the iNOS promoter. ..
- Lin X, Liang Y, Sun B, Liang M, Shi Y, Brunicardi F, et al. Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol. 2003;23:9081-93 pubmed..We conclude that the nuclear functions and physical interaction of Smad6 and CtBP provide a novel mechanism for the transcriptional regulation by inhibitory Smads. ..
- Boerboom D, White L, Dalle S, Courty J, Richards J. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Cancer Res. 2006;66:1964-73 pubmed..Together, these results suggest that misregulated Wnt/beta-catenin signaling alters the fate of granulosa cells and that the GCT that arise in Catnb(flox(ex3)/+);Amhr2(cre/+) mice result from the clonal expansion of metaplastic cells. ..
- Rivera C, Lloyd R. Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors. Virology. 2008;375:59-72 pubmed publisher..The results further elucidate complex mechanisms where multiple inherent PABP conformations and protein and RNA interactions both serve to differentially regulate PABP cleavage by 3CD, 3C(pro) and 2A(pro)...
- Vachon G, Cohen B, Pfeifle C, McGuffin M, Botas J, Cohen S. Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell. 1992;71:437-50 pubmed..Repression of limb development in the abdomen appears to be controlled at the DII enhancer. Thus DII may serve as a downstream target gene through which the homeotic genes control abdominal segment identity in the Drosophila embryo. ..
- Hoffmaster A, Koehler T. Autogenous regulation of the Bacillus anthracis pag operon. J Bacteriol. 1999;181:4485-92 pubmed..The steady-state level of atxA mRNA was also increased in the pagR mutant. The mutant phenotype was complemented by addition of pagR in trans on a multicopy plasmid...
- Frankfort B, Nolo R, Zhang Z, Bellen H, Mardon G. senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye. Neuron. 2001;32:403-14 pubmed..A genetic model of R8 differentiation is presented. ..
- Shahbazian M, Antalffy B, Armstrong D, Zoghbi H. Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum Mol Genet. 2002;11:115-24 pubmed..Our data suggest that MeCP2 may become abundant only once a neuron has reached a certain degree of maturity, and that this may explain some aspects of the RTT phenotype. ..
- Cook J, Davis B, Cai S, Barrett J, Conti C, Walker C. Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance. Proc Natl Acad Sci U S A. 2005;102:8644-9 pubmed
- Lee B, Follen M, Rodriquez G, Shen D, Malpica A, Shearer W, et al. Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions. Cancer. 2006;107:999-1007 pubmed
- Wei Y, Chen Y, Li L, Lang J, Yeh S, Shi B, et al. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol. 2011;13:87-94 pubmed publisher..These findings define a signalling link between CDK1 and EZH2 that may have an important role in diverse biological processes, including cancer-cell invasion and osteogenic differentiation of mesenchymal stem cells. ..
- Rivera Pérez J, Mallo M, Gendron Maguire M, Gridley T, Behringer R. Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development. Development. 1995;121:3005-12 pubmed..These results demonstrate that gsc is not essential for organizer activity in the mouse but is required later during embryogenesis for craniofacial and rib cage development. ..
- Sun H, Rodin A, Zhou Y, Dickinson D, Harper D, Hewett Emmett D, et al. Evolution of paired domains: isolation and sequencing of jellyfish and hydra Pax genes related to Pax-5 and Pax-6. Proc Natl Acad Sci U S A. 1997;94:5156-61 pubmed..From this analysis and the gene structure, we propose that modern Pax-4/6 and Pax-2/5/8 genes evolved from an ancestral gene similar to cnidarian Pax-B, having both the homeodomain and the octapeptide. ..
- Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, et al. GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. J Biol Chem. 2000;275:20942-8 pubmed..High level expression of GCIP in terminally differentiated tissues and the inhibition of E2F1 transcription activation suggest that GCIP could play an important role in controlling cell differentiation and proliferation. ..
- Swint Kruse L, Elam C, Lin J, Wycuff D, Shive Matthews K. Plasticity of quaternary structure: twenty-two ways to form a LacI dimer. Protein Sci. 2001;10:262-76 pubmed..Thus, the 360-amino acid scaffold of LacI allows plasticity of its quaternary structure. The periplasmic binding proteins may require only minimal changes to facilitate oligomerization similar to the repressor proteins. ..
- Schrader L, Anderson A, Mayne A, Pfaffinger P, Sweatt J. PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. J Neurosci. 2002;22:10123-33 pubmed..2-encoded A channels by PKA. Overall, our studies indicate that PKA must of necessity act on a supramolecular complex of pore-forming alpha-subunits plus ancillary subunits to alter channel properties. ..
- Mishra S, Yang Z, Mazumdar A, Talukder A, Larose L, Kumar R. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004;23:4422-9 pubmed
- Wang J, Tao Y, Reim I, Gajewski K, Frasch M, Schulz R. Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster. Mol Cell Biol. 2005;25:4200-10 pubmed..Such findings implicate Toll as a critical cell adhesion molecule in the alignment and migration of cardioblasts during dorsal vessel morphogenesis...
- Singh R, Barnes C, Talukder A, Fuqua S, Kumar R. Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein. Cancer Res. 2005;65:10594-601 pubmed
- Zhu J, Shalel Levanon S, Bennett G, San K. The YfiD protein contributes to the pyruvate formate-lyase flux in an Escherichia coli arcA mutant strain. Biotechnol Bioeng. 2007;97:138-43 pubmed..Relatively higher lactate production was seen in the yfiDarcA mutant than the other strains, which was due to the lower total flux through PFL and PDH toward AcCoA in this strain. ..
- Kim S, Levenson J, Korsmeyer S, Sweatt J, Schumacher A. Developmental regulation of Eed complex composition governs a switch in global histone modification in brain. J Biol Chem. 2007;282:9962-72 pubmed..Thus, this study suggests dynamic regulation of chromatin complex composition as a molecular mechanism to co-opt constituents of developmental pathways into the regulation of neuronal memory formation in adult brain. ..
- Fu J, Yoon H, Qin J, Wong J. Regulation of P-TEFb elongation complex activity by CDK9 acetylation. Mol Cell Biol. 2007;27:4641-51 pubmed..These results suggest that acetylation of CDK9 is an important posttranslational modification that is involved in regulating P-TEFb transcriptional elongation function. ..
- He B, Feng Q, Mukherjee A, Lonard D, DeMayo F, Katzenellenbogen B, et al. A repressive role for prohibitin in estrogen signaling. Mol Endocrinol. 2008;22:344-60 pubmed..Our results indicate that PHB functions as a transcriptional corepressor for ERalpha in vitro and in vivo, and that its heteromerization with REA acts as a novel mechanism to limit its corepressor activity. ..
- Yang Y, Chang B, Samson S, Li M, Chan L. The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res. 2009;37:2529-38 pubmed publisher..This study uncovers a role of Glis3 for regulation of insulin gene expression and expands our understanding of its role in the beta cell. ..
- Chen L, Ma Y, Kim E, Yu W, Schwartz R, Qian L, et al. Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival. PLoS ONE. 2012;7:e31005 pubmed publisher..The regulation of Hey2 expression by Ezh2 may be independent of Notch signaling activity. Our work defines an indispensible role of the chromatin remodeling factor Ezh2 in normal cardiovascular development. ..
- Wu S, Cheng C, Lanz R, Wang T, Respress J, Ather S, et al. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013;25:417-26 pubmed publisher..Collectively, our results reveal that COUP-TFII confers atrial identity through direct binding and by modulating expression of a broad spectrum of genes that have an impact on atrial development and function. ..
- Blattner M, Liu D, Robinson B, Huang D, Poliakov A, Gao D, et al. SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer Cell. 2017;31:436-451 pubmed publisher..Using these models and human prostate cancer samples, we show that SPOP mutation activates both PI3K/mTOR and androgen receptor signaling, effectively uncoupling the normal negative feedback between these two pathways. ..
- Davis R, Shen W, Sandler Y, Heanue T, Mardon G. Characterization of mouse Dach2, a homologue of Drosophila dachshund. Mech Dev. 2001;102:169-79 pubmed..The identification of human DACH2 sequences at Xq21 suggests a possible role for this gene in Allan-Herndon syndrome, Miles-Carpenter syndrome, X-linked cleft palate and/or Megalocornea. ..
- Henkel J, Du H, Yang P, Qyang Y, Kansra S, Ko M, et al. Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe. Differentiation. 2001;67:98-106 pubmed..Our results lead us to propose that Bob1-related proteins may play diverse roles in eukaryotic organisms...
- Kim S, Fang X, Ji H, Paulson A, Daniel J, Ciesiolka M, et al. Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120(ctn) in Xenopus laevis. J Biol Chem. 2002;277:8202-8 pubmed..The significance of the XKaiso-p120(ctn) interaction has yet to be determined, but it may include transducing information from cadherin-mediated cell-cell contacts to transcriptional processes within the nucleus. ..
- Barnes C, Vadlamudi R, Mishra S, Jacobson R, Li F, Kumar R. Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat Struct Biol. 2003;10:622-8 pubmed..Pak1 regulation of CtBP represents a new model of corepressor regulation whereby cellular signaling cascades may influence gene expression in mammalian cells. ..
- Lan Z, Gu P, Xu X, Jackson K, DeMayo F, O Malley B, et al. GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility. EMBO J. 2003;22:4070-81 pubmed..Our results show that GCNF directly regulates paracrine communication between the oocyte and somatic cells by regulating the expression of BMP-15 and GDF-9, to affect female fertility. ..
- Su X, Kameoka S, Lentz S, Majumder S. Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation. Mol Cell Biol. 2004;24:8018-25 pubmed
- Peterson T, Karmakar S, Pace M, Gao T, Smith C. The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity. Mol Cell Biol. 2007;27:5933-48 pubmed..Taken together, these data indicate that SMRT, in conjunction with gene-specific and cell-dependent factors, is required for positively regulating agonist-dependent ERalpha transcriptional activity. ..
- Wang W, Wikramanayake A, Gonzalez Rimbau M, Vlahou A, Flytzanis C, Klein W. Very early and transient vegetal-plate expression of SpKrox1, a Krüppel/Krox gene from Stronglyocentrotus purpuratus. Mech Dev. 1996;60:185-95 pubmed..As the vegetal-plate cells invaginated into the blastopore, SpKrox1 expression was lost, suggesting that its role was not in endoderm differentiation per se but rather in the initial establishment of the vegetal plate...
- Tang H, Chao L, Saunders G. Functional analysis of paired box missense mutations in the PAX6 gene. Hum Mol Genet. 1997;6:381-6 pubmed..Our data support the haploid-insufficiency hypothesis of aniridia, and the hypothesis that R26G is a hypomorphic allele. ..
- Smith C, Nawaz Z, O Malley B. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol. 1997;11:657-66 pubmed
- Au K, Rodriguez J, Finch J, Volcik K, Roach E, Delgado M, et al. Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients. Am J Hum Genet. 1998;62:286-94 pubmed
- Gajewski K, Kim Y, Choi C, Schulz R. Combinatorial control of Drosophila mef2 gene expression in cardiac and somatic muscle cell lineages. Dev Genes Evol. 1998;208:382-92 pubmed..The analysis of D-mef2-lacZ fusion genes in mutant embryos revealed that the specification of the muscle precursor cells involved the wingless gene and the activation of a receptor tyrosine kinase signaling pathway. ..
- Xu Z, Saunders G. PAX6 intronic sequence targets expression to the spinal cord. Dev Genet. 1998;23:259-63 pubmed..These studies also suggested that PAX6 was not only conserved at the functional level, but at the transcriptional level as well. ..
- Singh S, Stellrecht C, Tang H, Saunders G. Modulation of PAX6 homeodomain function by the paired domain. J Biol Chem. 2000;275:17306-13 pubmed..This study demonstrates that the two subdomains of the paired domain influence the function of the homeodomain differentially and also provides an explanation for the difference in phenotypes associated with these mutations. ..
- Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen J. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. Cell Growth Differ. 2000;11:343-54 pubmed..These results suggest that p190-B may be required for virgin mammary gland development, and its aberrant expression may occur in breast cancer. ..
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