Experts and Doctors on pyruvates in College Station, Texas, United States
Locale: College Station, Texas, United States
Chao Y, Patnaik R, Roof W, Young R, Liao J. Control of gluconeogenic growth by pps and pck in Escherichia coli. J Bacteriol. 1993;175:6939-44 pubmed
..Further increases in either Pck or Pps above the optimal levels become growth inhibitory, and the growth yield for oxygen is reduced, indicating less efficient growth. ..
Patnaik R, Roof W, Young R, Liao J. Stimulation of glucose catabolism in Escherichia coli by a potential futile cycle. J Bacteriol. 1992;174:7527-32 pubmed
..A model for the stimulation of glucose uptake is presented; it involves an increased PEP/pyruvate ratio caused by the overexpressed Pps activity, leading to a stimulation of the PEP:sugar phosphotransferase system. ..
Sharma V, Sharma S, Hoener zu Bentrup K, McKinney J, Russell D, Jacobs W, et al
. Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000;7:663-8 pubmed publisher
..The structure of a C191S mutant of the enzyme with the inhibitor 3-nitropropionate provides further insight into the reaction mechanism...
Dey S, Burton R, Grant G, Sacchettini J. Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase. Biochemistry. 2008;47:8271-82 pubmed publisher
..Furthermore, comparison to the structure of a truncated form of human d-3-phosphoglycerate dehydrogenase with cofactor and a substrate analog, provides insight into the conformational changes that occur during catalysis. ..