Experts and Doctors on protein transport in Houston, Texas, United States

Summary

Locale: Houston, Texas, United States
Topic: protein transport

Top Publications

  1. ECHENDU C, Ling P. Regulation of Sp100A subnuclear localization and transcriptional function by EBNA-LP and interferon. J Interferon Cytokine Res. 2008;28:667-78 pubmed publisher
    ..We also show that IFN-beta does not inhibit EBNA-LP coactivation function. The results suggest that EBNA-LP might play a role in EBV-evasion of IFN-mediated antiviral responses. ..
  2. GONZALEZ Y, Saito A, Sazer S. Fission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear lamina. Nucleus. 2012;3:60-76 pubmed publisher
    ..These data indicate that the core functions of the nuclear lamina are conserved between fungi and animal cells and can be performed in fission yeast, without lamins or other intermediate filament proteins. ..
  3. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, et al. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem. 2007;282:11221-9 pubmed
    ..Phosphorylation of beta-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that AKT-dependent regulation of beta-catenin plays a critical role in tumor invasion and development. ..
  4. Rajagopalan L, Organ Darling L, Liu H, Davidson A, Raphael R, Brownell W, et al. Glycosylation regulates prestin cellular activity. J Assoc Res Otolaryngol. 2010;11:39-51 pubmed publisher
    ..We speculate that the cholesterol regulation of prestin occurs through localization to and internalization from membrane microdomains by clathrin- and caveolin-dependent mechanisms. ..
  5. Cheng J, Wang Y, Ma Y, Chan B, Yang M, Liang A, et al. The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts. Circ Res. 2010;107:1265-74 pubmed publisher
    ..However, it is unknown what intracellular growth signal leads to proliferation of venous SMCs...
  6. Sharp T, Guix S, Katayama K, Crawford S, Estes M. Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. PLoS ONE. 2010;5:e13130 pubmed publisher
    ..This unique and well-conserved human norovirus motif is therefore an appealing target for antiviral drug development. ..
  7. Hung M, Link W. Protein localization in disease and therapy. J Cell Sci. 2011;124:3381-92 pubmed publisher
    ..We discuss the concepts involved in the therapeutic restoration of disrupted physiological protein localization and therapeutic mislocalization as a strategy to inactivate disease-causing proteins. ..
  8. Woodfield S, Graves H, Hernandez J, Bergmann A. De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis. PLoS ONE. 2013;8:e56021 pubmed publisher
    ..This is the first rigorous study of tissues predominantly mutant for endocytic nTSGs and provides clear evidence for cooperation among de-regulated signaling pathways leading to tumorigenesis. ..
  9. Bhatty M, Laverde Gomez J, Christie P. The expanding bacterial type IV secretion lexicon. Res Microbiol. 2013;164:620-39 pubmed publisher
    ..Finally, we introduce the concept of the 'minimized' T4SSs; these are systems composed of a conserved set of 5-6 subunits that are distributed among many Gram-positive and some Gram-negative species. ..

More Information

Publications186 found, 100 shown here

  1. Biswas A, Mitchell D, Johnson D. E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Res. 2014;74:3369-77 pubmed publisher
    ..Moreover, E2f1(S29A/) (S29A) mice display increased sensitivity to UV-induced skin carcinogenesis. This knock-in mouse model thus links the ability of E2F1 to directly promote DNA repair with the suppression of tumor development. ..
  2. Opal P, Garcia J, Propst F, Matilla A, Orr H, Zoghbi H. Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis. J Biol Chem. 2003;278:34691-9 pubmed
    ..LANP thus could play a key role in neuronal development and/or neurodegeneration by its interactions with microtubule associated proteins. ..
  3. Zhou L, Wu H, Lee P, Wang Z. Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells. J Mol Endocrinol. 2006;37:283-300 pubmed
  4. Sha Y, Pandit L, Zeng S, Eissa N. A critical role for CHIP in the aggresome pathway. Mol Cell Biol. 2009;29:116-28 pubmed publisher
    ..This study reveals a critical role for CHIP in the aggresome pathway. ..
  5. Rezvani K, Teng Y, De Biasi M. The ubiquitin-proteasome system regulates the stability of neuronal nicotinic acetylcholine receptors. J Mol Neurosci. 2010;40:177-84 pubmed publisher
    ..The present data, together with previous results showing that the alpha7 nAChR subunit is a target of the UPS, point to a prominent role of the proteasome in nAChR trafficking. ..
  6. Rasband M. Clustered K+ channel complexes in axons. Neurosci Lett. 2010;486:101-6 pubmed publisher
    ..These interacting proteins play important roles in recruiting K+ channels to distinct axonal domains. Here, I review the composition, functions, and mechanism of localization of these K+ channel complexes in axons. ..
  7. Yosef N, Ubogu E. ?(M)?(2)-integrin-intercellular adhesion molecule-1 interactions drive the flow-dependent trafficking of Guillain-Barré syndrome patient derived mononuclear leukocytes at the blood-nerve barrier in vitro. J Cell Physiol. 2012;227:3857-75 pubmed publisher
  8. Koshkina N, Yang G, Kleinerman E. Inhibition of Cdc42-interacting protein 4 (CIP4) impairs osteosarcoma tumor progression. Curr Cancer Drug Targets. 2013;13:48-56 pubmed
    ..Although the lack of CIP4 in tumor cells did not prevent formation of metastasis, it did substantially delay their formation in the animals' lungs. ..
  9. Rahman G, Shanker S, Lewin N, Kedei N, Hill C, Prasad B, et al. Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase C? (PKC?). Biochem J. 2013;451:33-44 pubmed publisher
    ..These results provide insights into the PKC? activator-binding domain, which will aid in future design of PKC?-selective molecules. ..
  10. Chen W, Shieh C, Swanger S, Tankovic A, Au M, McGuire M, et al. GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function. J Hum Genet. 2017;62:589-597 pubmed publisher
  11. Huang S, Chang I, Lin W, Ye W, Luo R, Lu Z, et al. ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins. Biosci Rep. 2009;30:159-68 pubmed publisher
    ..Thus ARHI-induced disruption of importin-binding to cargo proteins, including STAT3, could serve as an important regulatory mechanism that contributes to the tumour-suppressor function of ARHI. ..
  12. Boonyaratanakornkit V. Scaffolding proteins mediating membrane-initiated extra-nuclear actions of estrogen receptor. Steroids. 2011;76:877-84 pubmed publisher
    ..Future studies defining physiological roles of ER extra-nuclear actions and crosstalk with its nuclear counterparts will be important to our overall understanding of estrogen and ER biological functions. ..
  13. Lei J, Mazumdar T, Martinez Moczygemba M. Three lysine residues in the common ? chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling. J Biol Chem. 2011;286:40091-103 pubmed publisher
    ..These findings establish that JAK kinase binding to ?c requires the presence of three critical ?c lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling. ..
  14. Zhang M, Sukhumalchandra P, Enyenihi A, St John L, Hunsucker S, Mittendorf E, et al. A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia. Clin Cancer Res. 2013;19:247-57 pubmed publisher
    ..CG is aberrantly expressed and processed in AML and is a novel immunotherapeutic target that warrants further development. ..
  15. Mamenko M, Zaika O, Boukelmoune N, Berrout J, O Neil R, Pochynyuk O. Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C. J Biol Chem. 2013;288:20306-14 pubmed publisher
    ..Although the PKA-dependent cascade promotes TRPV4 trafficking and translocation to the apical membrane, the PKC-dependent pathway increases the activity of the channel on the plasma membrane. ..
  16. Chen Z, Pittman E, Romaguera J, Fayad L, Wang M, Neelapu S, et al. Nuclear translocation of B-cell-specific transcription factor, BACH2, modulates ROS mediated cytotoxic responses in mantle cell lymphoma. PLoS ONE. 2013;8:e69126 pubmed publisher
    ..Therapies that inhibit BACH2 phosphorylation could be the key for increasing bortezomib cytotoxic response in patients. ..
  17. Christie P, Whitaker N, González Rivera C. Mechanism and structure of the bacterial type IV secretion systems. Biochim Biophys Acta. 2014;1843:1578-91 pubmed publisher
    ..tumefaciens VirB/VirD4 T4SS and related conjugation systems. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey. ..
  18. He L, Perkins G, Poblenz A, Harris J, Hung M, Ellisman M, et al. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A. 2003;100:1022-7 pubmed
    ..These results have relevance for therapies in a wide variety of progressive retinal and neuronal degenerations where Ca(2+) overload, lead exposure, andor mitochondrial dysfunction occur. ..
  19. Qiu J, Wong J, Tweardy D, Dong S. Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor beta. Oncogene. 2006;25:3982-93 pubmed
    ..Therefore, AML1 fusion proteins may interfere with normal AML1 function due to aberrant nuclear dynamics, which leads to spatial and temporal sequestration of CBFbeta and perhaps other coregulators critical for myeloid differentiation. ..
  20. Konde V, Eichberg J. Myelin protein zero: mutations in the cytoplasmic domain interfere with its cellular trafficking. J Neurosci Res. 2006;83:957-64 pubmed
  21. Chung S, Frese K, Weiss R, Prasad B, Javier R. A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles. J Virol. 2007;81:4787-97 pubmed
  22. Belaguli N, Zhang M, Brunicardi F, Berger D. Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation. PLoS ONE. 2012;7:e48019 pubmed publisher
    ..Sumoylation increased the transcriptional activity of FOXA2 on Pdx-1 area I enhancer. Together, our results show that sumoylation regulates FOXA2 protein expression and activity. ..
  23. Cho K, Park J, Piggott A, Salim A, Gorfe A, Parton R, et al. Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins. J Biol Chem. 2012;287:43573-84 pubmed publisher
  24. Yang W, Lu Z. Regulation and function of pyruvate kinase M2 in cancer. Cancer Lett. 2013;339:153-8 pubmed publisher
  25. Hossain M, Shifat R, Li J, Luo X, Hess K, Rivera Molina Y, et al. TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation. Mol Cell Biol. 2017;37: pubmed publisher
  26. Xu J, Liu D, Gill G, Songyang Z. Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J Cell Biol. 2001;154:699-705 pubmed
    ..Therefore, CISK and Akt have evolved to utilize different lipid binding domains to accomplish a similar mechanism of activation in response to PI-3 kinase signaling. ..
  27. Sudo Y, Spudich J. Three strategically placed hydrogen-bonding residues convert a proton pump into a sensory receptor. Proc Natl Acad Sci U S A. 2006;103:16129-34 pubmed
    ..The results demonstrate that evolution accomplished an elegant but simple conversion: The essential differences between transport and signaling proteins in the rhodopsin family are far less than previously imagined...
  28. Gajewski K, Schulz R. CF2 represses Actin 88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila. PLoS ONE. 2010;5:e10713 pubmed publisher
  29. Rosenfeld J, Moore R, Zimmer K, Alpizar Foster E, Dai W, Zarka M, et al. Lysosome proteins are redistributed during expression of a GTP-hydrolysis-defective rab5a. J Cell Sci. 2001;114:4499-508 pubmed
    ..These results suggest that expression of a GTPase-defective rab5a affects lysosome biogenesis by alteration of traffic between lysosomes and endosomes. ..
  30. Frese K, Latorre I, Chung S, Caruana G, Bernstein A, Jones S, et al. Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor. EMBO J. 2006;25:1406-17 pubmed
    ..These findings establish the first known function for Dlg1 in virus-mediated cellular transformation and also surprisingly expose a previously unrecognized oncogenic activity encoded by this suspected cellular tumor suppressor gene. ..
  31. Sturm A, Rajagopalan L, Yoo D, Brownell W, Pereira F. Functional expression and microdomain localization of prestin in cultured cells. Otolaryngol Head Neck Surg. 2007;136:434-9 pubmed
    ..Depleting membrane cholesterol content altered prestin localization and NLC. Prestin activity in HEK 293 cells results from expression in the plasma membrane and altering membrane lipid content affects prestin localization and activity. ..
  32. Guo W, Wu S, Wang L, Wang R, Wei X, Liu J, et al. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol Cancer Ther. 2009;8:441-8 pubmed publisher
    ..Together, our results suggest that oncrasin-1 suppresses the function of RNA processing machinery and that PKCiota might be involved in the biological function of RNA processing complexes. ..
  33. Hicks K, O Neil R, Dubinsky W, Brown R. TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress. Am J Physiol Cell Physiol. 2010;298:C1583-93 pubmed publisher
    ..These data suggest that hypoxic stress triggers alterations to cytoskeletal structure that contribute to BBB disruption and that calcium influx through TRPC channels contributes to these events. ..
  34. Gong Z, Chen J. E3 ligase RFWD3 participates in replication checkpoint control. J Biol Chem. 2011;286:22308-13 pubmed publisher
    ..Taken together, our results suggest that RFWD3 and RPA2 functionally interact and participate in replication checkpoint control. ..
  35. Crawford S, Hyser J, Utama B, Estes M. Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-? signaling is required for rotavirus replication. Proc Natl Acad Sci U S A. 2012;109:E3405-13 pubmed publisher
    ..These studies identify a unique mechanism of virus-mediated, calcium-activated signaling that initiates autophagy and hijacks this membrane trafficking pathway to transport viral proteins to sites of viral assembly. ..
  36. Sirisaengtaksin N, Gireud M, Yan Q, Kubota Y, Meza D, Waymire J, et al. UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation. J Biol Chem. 2014;289:3026-39 pubmed publisher
    ..We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 enable the endosomal sorting and lysosomal degradation of the EGFR. ..
  37. Suga Y, Jarnik M, Attar P, Longley M, Bundman D, Steven A, et al. Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma. J Cell Biol. 2000;151:401-12 pubmed
    ..Thus, deposition of the mutant protein in the nucleus appears to interfere with late stages of epidermal differentiation, resulting in a VS-like phenotype. ..
  38. Angers A, Fioravante D, Chin J, Cleary L, Bean A, Byrne J. Serotonin stimulates phosphorylation of Aplysia synapsin and alters its subcellular distribution in sensory neurons. J Neurosci. 2002;22:5412-22 pubmed
    ..These experiments indicate that synapsin and its regulation by 5-HT may play an important role in the modulation of SV trafficking in short-term synaptic plasticity...
  39. Deng W, Wu K. Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J Immunol. 2003;171:6581-8 pubmed
    ..We conclude that p300 is essential for iNOS transcription. Our results suggest that p300 HAT acetylates the p50 subunit of NF-kappaB, thereby increasing NF-kappaB binding and NF-kappaB mediated transactivation. ..
  40. Wu X, Frost J. Multiple Rho proteins regulate the subcellular targeting of PAK5. Biochem Biophys Res Commun. 2006;351:328-35 pubmed
    ..These data indicate that PAK5 is directed to distinct subcellular locations by different Rho family small G proteins as well as by intrinsic targeting sequences. ..
  41. Acconcia F, Barnes C, Singh R, Talukder A, Kumar R. Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. Proc Natl Acad Sci U S A. 2007;104:6782-7 pubmed
    ..Together, these results suggest that ILK is a PAK1 substrate, undergoes phosphorylation-dependent shuttling between the cell nucleus and cytoplasm, and interacts with gene-regulatory chromatin. ..
  42. Efendiev R, Das Panja K, Cinelli A, Bertorello A, Pedemonte C. Localization of intracellular compartments that exchange Na,K-ATPase molecules with the plasma membrane in a hormone-dependent manner. Br J Pharmacol. 2007;151:1006-13 pubmed
    ..The intracellular compartments containing Na,K-ATPase molecules are located just underneath the plasma membrane. ..
  43. Huichalaf C, Schoser B, Schneider Gold C, Jin B, Sarkar P, Timchenko L. Reduction of the rate of protein translation in patients with myotonic dystrophy 2. J Neurosci. 2009;29:9042-9 pubmed publisher
  44. Kingeter L, Paul S, Maynard S, Cartwright N, Schaefer B. Cutting edge: TCR ligation triggers digital activation of NF-kappaB. J Immunol. 2010;185:4520-4 pubmed publisher
    ..Thus, similar to the TCR-to-MAPK signaling cascade, analog Ag inputs are converted to digital activation outputs to NF-?B at an early step downstream of TCR ligation. ..
  45. Grindel B, Rohe B, Safford S, Bennett J, Farach Carson M. Tumor necrosis factor-α treatment of HepG2 cells mobilizes a cytoplasmic pool of ERp57/1,25D₃-MARRS to the nucleus. J Cell Biochem. 2011;112:2606-15 pubmed publisher
    ..Immunostaining for both ERp57-GFP and p65 after TNF-α treatment indicated that nuclear translocation of these two proteins occurs independently in HepG2 cells. ..
  46. Bharadwaj U, Marin Muller C, Li M, Chen C, Yao Q. Mesothelin confers pancreatic cancer cell resistance to TNF-?-induced apoptosis through Akt/PI3K/NF-?B activation and IL-6/Mcl-1 overexpression. Mol Cancer. 2011;10:106 pubmed publisher
    ..Further, for the success of TNFerade + gemcitabine to be successful, we feel the simultaneous inhibition of components of this axis is also essential. ..
  47. Li L, Ren C, Yang G, Fattah E, Goltsov A, Kim S, et al. GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction. Cancer Res. 2011;71:7694-704 pubmed publisher
    ..Furthermore, they reveal parallel mechanisms of c-myc downregulation by GLIPR1 that when ablated in the prostate are sufficient to drive c-Myc expression and malignant development. ..
  48. Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, et al. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012;26:1959-71 pubmed publisher
    ..Collectively, these data suggest that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1. ..
  49. Burkhart S, Lingard M, Bartel B. Genetic dissection of peroxisome-associated matrix protein degradation in Arabidopsis thaliana. Genetics. 2013;193:125-41 pubmed publisher
    ..The isolation of pex6-2 as a pfl mutant supports the hypothesis that matrix proteins can exit the peroxisome for cytosolic degradation...
  50. Eraso J, Markillie L, Mitchell H, Taylor R, Orr G, Margolin W. The highly conserved MraZ protein is a transcriptional regulator in Escherichia coli. J Bacteriol. 2014;196:2053-66 pubmed publisher
    ..In support of this, purified MraZ could directly bind to a putative operator site upstream of mioC, one of the repressed genes identified by RNA-seq...
  51. Anvari S, Grimbergen A, Davis C, Makedonas G. Protein transport inhibitors downregulate the expression of LAG-3 on regulatory T cells. J Immunol Methods. 2017;447:47-51 pubmed publisher
    ..Therefore, the simultaneous assessment of Treg phenotype and function is complicated by the use of protein transport inhibitors. ..
  52. Lorenzetti F, Baxter D, Byrne J. Molecular mechanisms underlying a cellular analog of operant reward learning. Neuron. 2008;59:815-28 pubmed publisher
    ..Our results demonstrate how these molecules can interact to mediate operant conditioning in an individual neuron important for the expression of the conditioned behavior. ..
  53. Zhang W, Xia X, Reisenauer M, Rieg T, Lang F, Kuhl D, et al. Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha. J Clin Invest. 2007;117:773-83 pubmed
    ..Thus, Af9 is a physiologic target of Sgk1, and Sgk1 negatively regulates the Dot1a-Af9 repressor complex that controls transcription of ENaCalpha and likely other aldosterone-induced genes. ..
  54. Sandur S, Pandey M, Sung B, Aggarwal B. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Mol Cancer Res. 2010;8:107-18 pubmed publisher
    ..Overall, these results suggest that the plumbagin inhibits STAT3 activation pathway through the induction of SHP-1 and this may mediate the sensitization of STAT3 overexpressing cancers to chemotherapeutic agents. ..
  55. Muhammad A, Lokhandwala M, Banday A. Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1 receptor dysfunction in obese rats. Am J Physiol Renal Physiol. 2011;300:F98-104 pubmed publisher
    ..Furthermore, this study supports previous observations that restoring D1R function contributes to blood pressure reduction in this model. ..
  56. Lai S, Wenaas A, Sandulache V, Hartman C, Chiao E, Kramer J, et al. Prognostic Significance of p16 Cellular Localization in Oropharyngeal Squamous Cell Carcinoma. Ann Clin Lab Sci. 2016;46:132-9 pubmed
    ..P16 localization may provide additional insight into OPSCC carcinogenesis, particularly in patients with heavy tobacco exposure. ..
  57. Jafar Nejad H, Andrews H, Acar M, Bayat V, Wirtz Peitz F, Mehta S, et al. Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 2005;9:351-63 pubmed
    ..Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila...
  58. Ly C, Altuntop M, Wang Y. Single-molecule study of viomycin's inhibition mechanism on ribosome translocation. Biochemistry. 2010;49:9732-8 pubmed publisher
    ..Our results imply that ribosome translocation is possibly a synergistic process of multiple decoupled local dynamics. ..
  59. Ohshiro K, Rayala S, Kondo S, Gaur A, Vadlamudi R, El Naggar A, et al. Identifying the estrogen receptor coactivator PELP1 in autophagosomes. Cancer Res. 2007;67:8164-71 pubmed
  60. Kunjilwar K, Qian Y, Pfaffinger P. Functional stoichiometry underlying KChIP regulation of Kv4.2 functional expression. J Neurochem. 2013;126:462-72 pubmed publisher
    ..Our results support the hypothesis that KChIPs enhances Kv4.2 functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression. ..
  61. Banday A, Fazili F, Lokhandwala M. Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving phosphatidylinositol 3-kinase and protein kinase C. Am J Physiol Renal Physiol. 2007;293:F877-84 pubmed
  62. Zhou B, Liao Y, Xia W, Spohn B, Lee M, Hung M. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol. 2001;3:245-52 pubmed
    ..Our results indicate that HER-2/neu induces cytoplasmic localization of p21Cip1/WAF1 through activation of Akt to promote cell growth, which may have implications for the oncogenic activity of HER-2/neu and Akt. ..
  63. Nishino M, Kurasawa Y, Evans R, Lin S, Brinkley B, Yu Lee L. NudC is required for Plk1 targeting to the kinetochore and chromosome congression. Curr Biol. 2006;16:1414-21 pubmed
    ..Thus, NudC functions as both a substrate and a spatial regulator of Plk1 at the kinetochore to promote chromosome congression. ..
  64. Carr H, Zuo Y, Oh W, Frost J. Regulation of focal adhesion kinase activation, breast cancer cell motility, and amoeboid invasion by the RhoA guanine nucleotide exchange factor Net1. Mol Cell Biol. 2013;33:2773-86 pubmed publisher
    ..These results demonstrate a previously unrecognized role for the Net1A isoform in controlling FAK activation during planar cell movement and amoeboid motility during extracellular matrix (ECM) invasion. ..
  65. Sun Q, Margolin W. Effects of perturbing nucleoid structure on nucleoid occlusion-mediated toporegulation of FtsZ ring assembly. J Bacteriol. 2004;186:3951-9 pubmed
    ..Although indirect effects are certainly possible with these experiments, the above data suggest that optimum NO activity may require specific organization and structure of the nucleoid. ..
  66. Tanji K, Tanaka T, Mori F, Kito K, Takahashi H, Wakabayashi K, et al. NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1. Am J Pathol. 2006;169:553-65 pubmed
  67. Manshouri T, Quintas Cardama A, Nussenzveig R, Gaikwad A, Estrov Z, Prchal J, et al. The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation. Cancer Sci. 2008;99:1265-73 pubmed publisher
    ..Flow cytometric analysis of expanded PV progenitor cells treated with CP-690,550 suggests a possible transition towards a pattern of erythroid differentiation resembling expanded cells from normal healthy controls. ..
  68. Stenoien D, Sen S, Mancini M, Brinkley B. Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Cell Motil Cytoskeleton. 2003;55:134-46 pubmed
    ..Collectively, these studies contrast the relative cellular dynamics of Aurora-A with other cytoskeletal proteins that share its micro-domains, and identify essential regions required for targeting and dynamics. ..
  69. Yamasaki F, Zhang D, Bartholomeusz C, Sudo T, Hortobagyi G, Kurisu K, et al. Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity. Mol Cancer Ther. 2007;6:2168-77 pubmed
  70. Herz H, Bergmann A. Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101. Biochem Soc Trans. 2009;37:204-7 pubmed publisher
    ..In the present paper, we review these studies and discuss a mechanism which may explain how loss of the human Tsg101 (tumour susceptibility gene 101), a vps23 orthologue, causes tumours. ..
  71. Hyser J, Utama B, Crawford S, Estes M. Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies. J Virol. 2012;86:4921-34 pubmed publisher
    ..These data suggest that elevated cytosolic calcium is a common critical process for all rotavirus strains. ..
  72. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012;14:1295-304 pubmed publisher
    ..In addition, levels of PKM2 Ser 37 phosphorylation correlate with EGFR and ERK1/2 activity in human glioblastoma specimens. Our findings highlight the importance of nuclear functions of PKM2 in the Warburg effect and tumorigenesis. ..
  73. Fehrenbacher N, Tojal da Silva I, Ramírez C, Zhou Y, Cho K, Kuchay S, et al. The G protein-coupled receptor GPR31 promotes membrane association of KRAS. J Cell Biol. 2017;216:2329-2338 pubmed publisher
    ..Silencing of GPR31 expression partially mislocalized KRAS4B, slowed the growth of KRAS-dependent tumor cells, and blocked KRAS-stimulated macropinocytosis. Our data suggest that GPR31 acts as a secretory pathway chaperone for KRAS4B. ..
  74. Trivedi M, Marwaha A, Lokhandwala M. Rosiglitazone restores G-protein coupling, recruitment, and function of renal dopamine D1A receptor in obese Zucker rats. Hypertension. 2004;43:376-82 pubmed
  75. Haridas V, Xu Z, Kitchen D, Jiang A, Michels P, Gutterman J. The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism. PLoS ONE. 2011;6:e28037 pubmed publisher
  76. Tapia H, Morano K. Hsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast. Mol Biol Cell. 2010;21:63-72 pubmed publisher
    ..Pharmacological inhibition of Hsp90 with macbecin in sporulating diploid cells also blocked spore formation, underscoring the importance of this chaperone in this developmental program. ..
  77. Pan S, Wang S, Utama B, Huang L, Blok N, Estes M, et al. Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system. Mol Biol Cell. 2011;22:2810-22 pubmed publisher
    ..Taken together, these data provide a potential mechanistic explanation for the spatial separation by which glycoprotein quality control components operate in mammalian cells. ..
  78. Kim E, Alvarez Baron C, Dryer S. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. Mol Pharmacol. 2009;75:466-77 pubmed publisher
    ..TRPC6 channels also play a role in the regulation of surface expression of a subset of podocyte BK(Ca) channels. ..
  79. Zhou J, Qin L, Tien J, Gao L, Chen X, Wang F, et al. Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner. J Biol Chem. 2012;287:17248-56 pubmed publisher
    ..1 is reduced drastically in the prostatic fluid and urine of mice with PCa. These results indicate that Nkx3.1 can function as a PTF to suppress PCa and the urinary Nkx3.1 may be a potential biomarker for PCa diagnosis. ..
  80. Berkova Z, Crawford S, Trugnan G, Yoshimori T, Morris A, Estes M. Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms. J Virol. 2006;80:6061-71 pubmed
    ..In rotavirus-infected cells, NSP4 colocalized with LC3 in cap-like structures associated with viroplasms, the site of nascent viral RNA replication, suggesting a possible new mechanism for the involvement of NSP4 in virus replication. ..
  81. Lingard M, Bartel B. Arabidopsis LON2 is necessary for peroxisomal function and sustained matrix protein import. Plant Physiol. 2009;151:1354-65 pubmed publisher
  82. Wang Z, Zhang F, He J, Wu P, Tay L, Cai M, et al. Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells. Dev Cell. 2017;43:186-197.e7 pubmed publisher
    ..Taken together, these results identify a role of PLD2-generated PA in the regulation of kinesin-1 motor functions and breast cancer metastasis and suggest PLD2 as a potential therapeutic target for metastatic breast cancer. ..
  83. Pullan L, Mullapudi S, Huang Z, Baldwin P, Chin C, Sun W, et al. The endosome-associated protein Hrs is hexameric and controls cargo sorting as a "master molecule". Structure. 2006;14:661-71 pubmed
    ..Based on our model, the Hrs hexamer interacts with the membrane and acts as a "master molecule" that presents multiple sites for protein binding. ..
  84. Tzeng H, Fan J, Vallejo J, Dong J, Chen X, Houser S, et al. Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. Am J Physiol Heart Circ Physiol. 2008;294:H1490-6 pubmed publisher
  85. Ling P, Tan J, Peng R. Nuclear-cytoplasmic shuttling is not required for the Epstein-Barr virus EBNA-LP transcriptional coactivation function. J Virol. 2009;83:7109-16 pubmed publisher
  86. Hu B, Lara Tejero M, Kong Q, Galan J, Liu J. In Situ Molecular Architecture of the Salmonella Type III Secretion Machine. Cell. 2017;168:1065-1074.e10 pubmed publisher
    ..These studies provide major insight into the structure and assembly of a broadly distributed protein secretion machine. ..
  87. Karpen H, Bukowski J, Hughes T, Gratton J, Sessa W, Gailani M. The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J Biol Chem. 2001;276:19503-11 pubmed
    ..These data suggest that caveolin-1 may be integral for sequestering the Hh receptor complex in these caveolin-enriched microdomains, which act as a scaffold for the interactions with the Hh protein. ..
  88. Pandit L, Kolodziejska K, Zeng S, Eissa N. The physiologic aggresome mediates cellular inactivation of iNOS. Proc Natl Acad Sci U S A. 2009;106:1211-5 pubmed publisher
    ..These results suggest that bronchial epithelial cells used the physiologic aggresome mechanism for iNOS inactivation. Our studies reveal a novel cellular strategy to terminate NO production via formation of the iNOS aggresome. ..
  89. Bonnen P, Yarham J, Besse A, Wu P, Faqeih E, Al Asmari A, et al. Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance. Am J Hum Genet. 2013;93:471-81 pubmed publisher
    ..Together our data demonstrate that mutations in FBXL4 are disease causing and establish FBXL4 as a mitochondrial protein with a possible role in maintaining mtDNA integrity and stability. ..
  90. Atmakuri K, Ding Z, Christie P. VirE2, a type IV secretion substrate, interacts with the VirD4 transfer protein at cell poles of Agrobacterium tumefaciens. Mol Microbiol. 2003;49:1699-713 pubmed
    ..Together, our findings establish for the first time that a protein substrate of a type IV secretion system is recruited to a member of the coupling protein superfamily...
  91. Fong K, Leung J, Li Y, Wang W, Feng L, Ma W, et al. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci. 2013;126:825-37 pubmed publisher
    ..Together, these data suggest that MTR120 is a novel MT-associated protein that directly stabilizes MTs and hence ensures the fidelity of cell division. ..
  92. Zhu Q, Xia L, Mills G, Lowell C, Touw I, Corey S. G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood. 2006;107:1847-56 pubmed
    ..These data suggest that the G-CSF-induced Lyn-PI3K-Akt pathway drives ROS production. One beneficial effect of therapeutic targeting of Lyn-PI3K-kinase-Akt cascade is abrogating ROS production. ..