Experts and Doctors on phytosterols in Dallas, Texas, United States
Locale: Dallas, Texas, United States
Patel S, Salen G, Hidaka H, Kwiterovich P, Stalenhoef A, Miettinen T, et al
. Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21. J Clin Invest. 1998;102:1041-4 pubmed
..By studying 10 well-characterized families with this disorder, we have localized the genetic defect to chromosome 2p21, between microsatellite markers D2S1788 and D2S1352 (maximum lodscore 4.49, theta = 0.0). ..
Yu L, Hammer R, Li Hawkins J, von Bergmann K, Lutjohann D, Cohen J, et al
. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A. 2002;99:16237-42 pubmed
Yang C, Yu L, Li W, Xu F, Cohen J, Hobbs H. Disruption of cholesterol homeostasis by plant sterols. J Clin Invest. 2004;114:813-22 pubmed
..Stigmasterol also activated the liver X receptor in a cell-based reporter assay. These data indicate that selected dietary plant sterols disrupt cholesterol homeostasis by affecting two critical regulatory pathways of lipid metabolism...
Yu L, von Bergmann K, Lutjohann D, Hobbs H, Cohen J. Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. J Lipid Res. 2005;46:1739-44 pubmed
..Together, these results indicate that pharmacological blockade of sterol absorption can ameliorate the deleterious metabolic effects of plant sterols even in the absence of G5 and G8...
Lee J, Kinch L, Borek D, Wang J, Wang J, Urbatsch I, et al
. Crystal structure of the human sterol transporter ABCG5/ABCG8. Nature. 2016;533:561-4 pubmed publisher
..The G5G8 structure provides a mechanistic framework for understanding sterol transport and the disruptive effects of mutations causing sitosterolaemia. ..