Experts and Doctors on multigene family in Dallas, Texas, United States


Locale: Dallas, Texas, United States
Topic: multigene family

Top Publications

  1. Kroon E, MacDonald R, Hammer R. The transcriptional regulatory strategy of the rat tissue kallikrein gene family. Genes Funct. 1997;1:309-19 pubmed
  2. Chen W, Goldstein J, Brown M. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J Biol Chem. 1990;265:3116-23 pubmed
    ..This occurrence is much more frequent than would be expected by chance alone. The possibility of a conditional role for the NPXY sequence in ligand-independent internalization of these proteins is discussed...
  3. Wines D, Brady J, Pritchett D, Roberts J, MacDonald R. Organization and expression of the rat kallikrein gene family. J Biol Chem. 1989;264:7653-62 pubmed
    ..The high sequence conservation within the upstream flanking regions of these genes suggests that a small number of nucleotide differences determines the disparate transcriptional specificity of individual family members. ..
  4. Kumanovics A, Madan A, Qin S, Rowen L, Hood L, Fischer Lindahl K. QUOD ERAT FACIENDUM: sequence analysis of the H2-D and H2-Q regions of 129/SvJ mice. Immunogenetics. 2002;54:479-89 pubmed
  5. Attia A, Sedillo J, Hoopman T, Liu W, Liu L, Brautigam C, et al. Identification of a bacteriocin and its cognate immunity factor expressed by Moraxella catarrhalis. BMC Microbiol. 2009;9:207 pubmed publisher
    ..catarrhalis. The killing activity of the McbC protein raises the possibility that it might serve to lyse other M. catarrhalis strains that lack the mcbABCI locus, thereby making their DNA available for lateral gene transfer...
  6. Trommsdorff M, Borg J, Margolis B, Herz J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem. 1998;273:33556-60 pubmed
  7. MacDonald R, Southard Smith E, Kroon E. Disparate tissue-specific expression of members of the tissue kallikrein multigene family of the rat. J Biol Chem. 1996;271:13684-90 pubmed
    ..A gradient of diversity of expression corresponds to the order of the genes within the kallikrein family locus. ..
  8. Pei J, Mitchell D, Dixon J, Grishin N. Expansion of type II CAAX proteases reveals evolutionary origin of ?-secretase subunit APH-1. J Mol Biol. 2011;410:18-26 pubmed publisher
    ..Remote similarity between APH-1 and membrane proteases sheds light on APH-1's evolutionary origin and raises the possibility that APH-1 may possess proteolytic activity in the current or ancestral form of ?-secretase. ..
  9. Willnow T, Goldstein J, Orth K, Brown M, Herz J. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J Biol Chem. 1992;267:26172-80 pubmed
    ..LRP and gp330 share a multiplicity of binding sites, and both may function as endocytosis-mediating receptors for a large number of ligands in different organs. ..

More Information


  1. Pei J, Grishin N. COG3926 and COG5526: a tale of two new lysozyme-like protein families. Protein Sci. 2005;14:2574-81 pubmed
    ..The predicted enzymatic activity is consistent with an experimental study on the zliS gene product from Zymomonas mobilis, suggesting that bacterial COG3926/DUF847 members might be activators of macromolecular secretion...
  2. Wandstrat A, Nguyen C, Limaye N, Chan A, Subramanian S, Tian X, et al. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity. 2004;21:769-80 pubmed
    ..While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes...
  3. May P, Herz J. LDL receptor-related proteins in neurodevelopment. Traffic. 2003;4:291-301 pubmed
    ..Here, we will summarize recent advances in our understanding of the molecular basis on which these receptors function during development. ..
  4. Missler M, Sudhof T. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. J Neurosci. 1998;18:3630-8 pubmed
    ..The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins. ..
  5. Cope L, Yogev R, Muller Eberhard U, Hansen E. A gene cluster involved in the utilization of both free heme and heme:hemopexin by Haemophilus influenzae type b. J Bacteriol. 1995;177:2644-53 pubmed
    ..These studies indicate that at least two and possible three gene products are required for utilization of heme bound to hemopexin by Hib strain DL42...
  6. Craft C, Whitmore D, Wiechmann A. Cone arrestin identified by targeting expression of a functional family. J Biol Chem. 1994;269:4613-9 pubmed
    ..The localization of C-arrestin to cone photoreceptors suggests that it, like others in the arrestin family, may bind to phosphorylated receptors and participate in deactivation of the phototransduction cascade. ..
  7. Porrello E, Johnson B, Aurora A, Simpson E, Nam Y, Matkovich S, et al. MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res. 2011;109:670-9 pubmed publisher
    ..These findings suggest that upregulation of the miR-15 family during the neonatal period may be an important regulatory mechanism governing cardiomyocyte cell cycle withdrawal and binucleation. ..
  8. Rothermel B, Vega R, Yang J, Wu H, Bassel Duby R, Williams R. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem. 2000;275:8719-25 pubmed
    ..The interaction between MCIP proteins and calcineurin may modulate calcineurin-dependent pathways that control hypertrophic growth and selective programs of gene expression in striated muscles. ..
  9. Lee J, Monson N, Lipsky P. The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing. J Immunol. 2000;165:6322-33 pubmed
    ..These events imply that the expressed fetal repertoire is shaped by exposure to self Ags. ..
  10. Henke R, Butow R, Perlman P. Maturase and endonuclease functions depend on separate conserved domains of the bifunctional protein encoded by the group I intron aI4 alpha of yeast mitochondrial DNA. EMBO J. 1995;14:5094-9 pubmed
    ..This study indicates that the two functions depend on separate domains of the intron-encoded protein. ..
  11. Brautigam C, Deka R, Ouyang Z, Machius M, Knutsen G, Tomchick D, et al. Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis. J Bacteriol. 2012;194:6771-81 pubmed publisher
    ..The findings presented herein, coupled with bioinformatic analyses of related proteins, point to Tp34's likely role in metal ion homeostasis in T. pallidum...
  12. Min S, Chang W, Sudhof T. E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Proc Natl Acad Sci U S A. 2007;104:3823-8 pubmed
  13. Porcella S, Popova T, Hagman K, Penn C, Radolf J, Norgard M. A mgl-like operon in Treponema pallidum, the syphilis spirochete. Gene. 1996;177:115-21 pubmed
    ..The existence of a mgl operon in T. pallidum thus may have important implications with respect to T. pallidum survival, tissue dissemination, and sensory transduction during virulence expression. ..
  14. Gerlach V, Aravind L, Gotway G, Schultz R, Koonin E, Friedberg E. Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. Proc Natl Acad Sci U S A. 1999;96:11922-7 pubmed
    ..In a phylogenetic tree, the mouse and human DinB1 proteins specifically group with E. coli DinB, suggesting a mitochondrial origin for these genes. The human DINB1 gene is localized to chromosome 5q13 and is widely expressed. ..
  15. Zhou Q, Gallagher R, Ufret Vincenty R, Li X, Olson E, Wang S. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci U S A. 2011;108:8287-92 pubmed publisher
    ..Manipulating miR-23/27 levels may have important therapeutic implications in neovascular age-related macular degeneration and other vascular disorders. ..
  16. Osborne Lawrence S, Welcsh P, Spillman M, Chandrasekharappa S, Gallardo T, Lovett M, et al. Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21. Genomics. 1995;25:248-55 pubmed
  17. Williams K, Renthal N, Gerard R, Mendelson C. The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor. Mol Endocrinol. 2012;26:1857-67 pubmed publisher
    ..Together, these findings identify miR-199a-3p/miR-214 as important regulators of myometrial contractility and provide new insight into strategies to prevent preterm birth. ..
  18. Xie C, Patel R, Wu T, Zhu J, Henry T, Bhaskarabhatla M, et al. PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr. Int Immunol. 2007;19:509-22 pubmed
    ..Hence, hypersignaling via the PI3K/AKT/mTOR axis appears to be an important mechanism underlying autoimmune lymphoproliferative disease, presenting itself as a potential target for therapeutic intervention. ..
  19. Duncan L, Nishii I, Harryman A, Buckley S, Howard A, Friedman N, et al. The VARL gene family and the evolutionary origins of the master cell-type regulatory gene, regA, in Volvox carteri. J Mol Evol. 2007;65:1-11 pubmed
    ..reinhardtii. Most importantly, our phylogenetic analysis suggests that a proto-regA gene was present in a common unicellular ancestor of V. carteri and C. reinhardtii and that this gene was lost in the latter lineage...
  20. Thangavel C, Boopathi E, Ertel A, Lim M, Addya S, Fortina P, et al. Regulation of miR106b cluster through the RB pathway: mechanism and functional targets. Cell Cycle. 2013;12:98-111 pubmed publisher
    ..These data provide a mechanistic basis for cross-talk between the RB pathway and p21 and PTEN through the regulation of the MCM7/miR106b locus. ..
  21. Nika J, Latimer J, Ward C, Blick R, Wagner N, Cope L, et al. Haemophilus ducreyi requires the flp gene cluster for microcolony formation in vitro. Infect Immun. 2002;70:2965-75 pubmed
    ..These results indicate that the flp gene cluster is essential for microcolony formation by H. ducreyi, whereas this phenotypic trait is not linked to the virulence potential of the pathogen, at least in this animal model of infection...
  22. McKay R, Peters J, Graff J. The casein kinase I family in Wnt signaling. Dev Biol. 2001;235:388-96 pubmed
    ..These studies advance our understanding of the mechanism of Wnt action and suggest that more than one CKI isoform is capable of transducing Wnt signals in vivo. ..
  23. Cope L, Lumbley S, Latimer J, Klesney Tait J, Stevens M, Johnson L, et al. A diffusible cytotoxin of Haemophilus ducreyi. Proc Natl Acad Sci U S A. 1997;94:4056-61 pubmed
    ..ducreyi was shown to bind to the H. ducreyi cdtC gene product. This soluble H. ducreyi cytotoxin may play a role in the development or persistence of the ulcerative lesions characteristic of chancroid...
  24. Baer R. TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. Semin Cancer Biol. 1993;4:341-7 pubmed
    ..Thus, TAL1, TAL2 and LYL1 constitute a unique family of bHLH proteins, each of which is a potential mediator of T cell leukaemogenesis. ..
  25. Amarneh B, De Leon Rangel J, Vik S. Construction of a deletion strain and expression vector for the Escherichia coli NADH:ubiquinone oxidoreductase (Complex I). Biochim Biophys Acta. 2006;1757:1557-60 pubmed
    ..A chromosomal deletion of all nuo genes has been achieved by homologous recombination. A vector that encodes all of the nuo genes has been constructed, and it expresses a functional enzyme. ..
  26. Cheek S, Ginalski K, Zhang H, Grishin N. A comprehensive update of the sequence and structure classification of kinases. BMC Struct Biol. 2005;5:6 pubmed
    ..Potential uses for this classification include deduction of protein function, structural fold, or enzymatic mechanism of poorly studied or newly discovered kinases based on proteins in the same family. ..
  27. Fernandez Chacon R, Sudhof T. Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions. J Neurosci. 2000;20:7941-50 pubmed
  28. Chan C, Scoggin S, Wang D, Cherry S, Dembo T, Greenberg B, et al. Systematic discovery of Rab GTPases with synaptic functions in Drosophila. Curr Biol. 2011;21:1704-15 pubmed publisher
    ..The tools presented here allow systematic functional studies of these Rabs and provide a method that is applicable to any large gene family in Drosophila. ..
  29. Sudhof T, Slaughter C, Leznicki I, Barjon P, Reynolds G. Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins. Proc Natl Acad Sci U S A. 1988;85:664-8 pubmed
    ..These data place the calelectrins and the lipocortins into the same gene family and suggest that these proteins have similar functions and have evolved from a common ancestor. ..
  30. Wines D, Brady J, Southard E, MacDonald R. Evolution of the rat kallikrein gene family: gene conversion leads to functional diversity. J Mol Evol. 1991;32:476-92 pubmed
    ..These analyses indicate an important role for gene conversion in the evolution of the functional diversity of these duplicated genes. ..
  31. McPhaul M, Marcelli M, Zoppi S, Wilson C, Griffin J, Wilson J. Mutations in the ligand-binding domain of the androgen receptor gene cluster in two regions of the gene. J Clin Invest. 1992;90:2097-101 pubmed
    ..These regions of the androgen receptor may be of particular importance for the formation and function of the hormone-receptor complex. ..