Genomes and Genes
Experts and Doctors on mice in Houston, Texas, United States
Locale: Houston, Texas, United States
Publications1186 found, 100 shown here
- Wu T, Wilhelmus K, Mitchell B. Experimental keratomycosis in a mouse model. Invest Ophthalmol Vis Sci. 2003;44:210-6 pubmed..To establish a murine model of corneal candidiasis that permits molecular evaluation of fungal adherence and invasion...
- Kishida K, Pao M, Holland S, Klann E. NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1. J Neurochem. 2005;94:299-306 pubmed..Taken together, our results suggest that ROS production, especially superoxide production via NADPH oxidase, is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1. ..
- Shishodia S, Aggarwal B. Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene. 2006;25:1463-73 pubmed
- Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo P, Kitada S, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006;10:375-88 pubmed..These data suggest that ABT-737 could be a highly effective antileukemia agent when the mechanisms of resistance identified here are considered. ..
- Mohamedali K, Poblenz A, Sikes C, Navone N, Thorpe P, Darnay B, et al. Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel. Cancer Res. 2006;66:10919-28 pubmed..This is a novel and unique mechanism of action for this class of agents and suggests a potentially new approach for treatment or prevention of tumor growth in bone. ..
- Kim E, Ridgway L, Zou S, Chiu Y, Dryer S. Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels. Neuroscience. 2007;146:1652-61 pubmed
- Agoulnik A. Relaxin and related peptides in male reproduction. Adv Exp Med Biol. 2007;612:49-64 pubmed..Thus, in this chapter we review the data related to the expression and function of relaxin and related peptides in male reproduction. ..
- Zhang Y, Zhang J, Lin Y, Lan Y, Lin C, Xuan J, et al. Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis. Development. 2008;135:775-84 pubmed publisher..Thus, the prostate-specific Frs2alpha(cn) mice provide a useful animal model for scrutinizing the molecular mechanisms underlying prostatic development and tumorigenesis. ..
- LaMarca H, Rosen J. Minireview: hormones and mammary cell fate--what will I become when I grow up?. Endocrinology. 2008;149:4317-21 pubmed publisher..Here we review recent studies on the involvement of hormone receptors and several transcription factors in mammary stem/progenitor cell differentiation and lineage commitment. ..
- Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass A, et al. Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression. J Biol Chem. 2008;283:24497-505 pubmed publisher..Our finding is the first report that substitution of key serine/threonine residues with acidic residues mimics the phosphorylated state of TAK1 and renders TAK1 active during its induced activation. ..
- Appel S. CD4+ T cells mediate cytotoxicity in neurodegenerative diseases. J Clin Invest. 2009;119:13-5 pubmed publisher..The results implicate the adaptive immune system in the pathogenesis of Parkinson neurodegeneration and provide a meaningful rationale for immune-based therapies for PD. ..
- Singh S, Yang D, Ravoori M, Han L, Kundra V. In vivo functional and anatomic imaging for assessment of in vivo gene transfer. Radiology. 2009;252:763-71 pubmed publisher..05). A combination of in vivo functional and anatomic imaging methods can help quantify gene expression after in vivo gene transfer. ..
- Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, et al. Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci. 2009;29:10788-801 pubmed publisher..We postulate that transsynaptic APP interaction modulates its synaptic function and that perturbed APP synaptic adhesion activity may contribute to synaptic dysfunction and AD pathogenesis. ..
- Chen S, Chen H, Yuan W, Wess J, Pan H. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. J Biol Chem. 2010;285:40427-37 pubmed publisher..M(5) is the predominant receptor subtype that potentiates glutamatergic synaptic transmission in the spinal cord. ..
- Bhat K, Salazar K, Balasubramaniyan V, Wani K, Heathcock L, Hollingsworth F, et al. The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev. 2011;25:2594-609 pubmed publisher..Our studies uncover a direct role for TAZ and TEAD in driving the MES differentiation of malignant glioma. ..
- Barria M, Gonzalez Romero D, Soto C. Cyclic amplification of prion protein misfolding. Methods Mol Biol. 2012;849:199-212 pubmed publisher..In this chapter, we describe a detailed protocol of the PMCA technique, highlighting some of the important technical aspects to obtain a successful and reproducible application of the technology. ..
- Tuvim M, Clement C, Huang E, Cote G, Evans S, Lei X, et al. Deletion of the gene encoding calcitonin and calcitonin gene-related peptide α does not affect the outcome of severe infection in mice. Am J Respir Cell Mol Biol. 2013;49:151-5 pubmed publisher..Nonetheless, our studies demonstrate that nonendocrine PCT expression is not necessary for adverse outcomes from sepsis. ..
- Wu S, Cheng C, Lanz R, Wang T, Respress J, Ather S, et al. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013;25:417-26 pubmed publisher..Collectively, our results reveal that COUP-TFII confers atrial identity through direct binding and by modulating expression of a broad spectrum of genes that have an impact on atrial development and function. ..
- Surveyor G, Gendler S, Pemberton L, Das S, Chakraborty I, Julian J, et al. Expression and steroid hormonal control of Muc-1 in the mouse uterus. Endocrinology. 1995;136:3639-47 pubmed..Collectively, these data indicate that Muc-1 expression in mouse uterine epithelium is strongly influenced by ovarian steroids. It is suggested that the loss of Muc-1 contributes to generation of a receptive uterine state. ..
- Molkentin J, Black B, Martin J, Olson E. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell. 1995;83:1125-36 pubmed
- Naya F, Huang H, Qiu Y, Mutoh H, DeMayo F, Leiter A, et al. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 1997;11:2323-34 pubmed..The nervous system appeared to develop normally, despite abundant expression of BETA2 in differentiating neurons. Thus, BETA2 is critical for the normal development of several specialized cell types arising from the gut endoderm. ..
- Hazarika P, Dham N, Patel P, Cho M, Weidner D, Goldsmith L, et al. Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. J Cell Biochem. 1999;75:147-59 pubmed..Thus, the function of flotillin 2 may resemble that of the goldfish optic nerve neuronal regeneration proteins, Reggie 1 and 2. ..
- Apostolakis E, Garai J, Lohmann J, Clark J, O Malley B. Epidermal growth factor activates reproductive behavior independent of ovarian steroids in female rodents. Mol Endocrinol. 2000;14:1086-98 pubmed
- Liao L, Kuang S, Yuan Y, Gonzalez S, O Malley B, Xu J. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. J Steroid Biochem Mol Biol. 2002;83:3-14 pubmed
- Yan W, Ma L, Burns K, Matzuk M. Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. Proc Natl Acad Sci U S A. 2004;101:7793-8 pubmed
- Takamoto N, Kurihara I, Lee K, DeMayo F, Tsai M, Tsai S. Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction. Mol Endocrinol. 2005;19:2299-308 pubmed
- Matin A, Nadeau J. Search for testicular cancer gene hits dead-end. Cell Cycle. 2005;4:1136-8 pubmed..The identity of Ter as Dead end and its function in PGCs will help clarify the role of editing in PGC biology and elucidate the causes of TGCTs in mice and humans. ..
- Kuo M, Wei Y, Yang X, Tatebe S, Liu J, Troncoso P, et al. Association of fragile site-associated (FSA) gene expression with epithelial differentiation and tumor development. Biochem Biophys Res Commun. 2006;340:887-93 pubmed..Moreover, levels of FSA expression are downregulated in tumors of these tissue origins. These results suggest that FSA also plays important roles in regulating mammalian epithelial growth and differentiation and tumor development. ..
- Mukherjee A, Amato P, Allred D, Fernandez Valdivia R, Nguyen J, O Malley B, et al. Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human. J Steroid Biochem Mol Biol. 2006;102:22-31 pubmed
- Chung A, Zhou S, Liao L, Tien J, Greenberg N, Xu J. Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice. Cancer Res. 2007;67:5965-75 pubmed..Inhibition of AIB1 expression or function in the prostate epithelium may be a potential strategy to suppress prostate cancer initiation and progression. ..
- Mohsenin A, Mi T, Xia Y, Kellems R, Chen J, Blackburn M. Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2007;293:L753-61 pubmed..There were no compensatory changes in the other adenosine receptors in the lungs of ADA/A(2A)R double knockout mice. These findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation. ..
- Balasenthil S, Gururaj A, Talukder A, Bagheri Yarmand R, Arrington T, Haas B, et al. Identification of Pax5 as a target of MTA1 in B-cell lymphomas. Cancer Res. 2007;67:7132-8 pubmed..Significance of these murine studies was established by evidence showing a widespread up-regulation of both MTA1 and Pax5 in DLBCL from humans. These observations provide in vivo genetic evidence for a role of MTA1 in lymphomagenesis. ..
- Samaco R, Mandel Brehm C, Chao H, Ward C, Fyffe Maricich S, Ren J, et al. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Proc Natl Acad Sci U S A. 2009;106:21966-71 pubmed publisher..These data support a cell-autonomous, MeCP2-dependent mechanism for the regulation of aminergic neurotransmitter synthesis contributing to unique behavioral phenotypes. ..
- McKeller M, Herrera Rodriguez S, Ma W, Ortiz Quintero B, Rangel R, Cande C, et al. Vital function of PRELI and essential requirement of its LEA motif. Cell Death Dis. 2010;1:e21 pubmed publisher..These findings may help to understand how bioenergetics is mechanistically connected with cell survival cues. ..
- Cowin R, Roscic A, Bui N, Graham D, Paganetti P, Jankowsky J, et al. Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington's disease transgenic mouse. Behav Brain Res. 2012;229:308-19 pubmed publisher..We believe that these data suggest a role for aggregation and inclusion localization in HD pathogenesis and propose a mechanism for the age of onset delay observed in R6/2 mice. ..
- Xu Monette Z, Young K. The TP53 tumor suppressor and autophagy in malignant lymphoma. Autophagy. 2012;8:842-5 pubmed publisher..Here we discuss the biological mechanisms of TP53 functional switches from apoptosis to autophagy, and provide a brief summary of how TP53 regulates autophagy through its transcriptional activity on 14 genes of the TP53 pathway. ..
- Deniger D, Switzer K, Mi T, Maiti S, Hurton L, Singh H, et al. Bispecific T-cells expressing polyclonal repertoire of endogenous ?? T-cell receptors and introduced CD19-specific chimeric antigen receptor. Mol Ther. 2013;21:638-47 pubmed publisher..Since CAR, SB, and aAPC have been adapted for human application, clinical trials can now focus on the therapeutic potential of polyclonal ?? T cells. ..
- Kamerkar S, LeBleu V, Sugimoto H, Yang S, Ruivo C, Melo S, et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. 2017;546:498-503 pubmed publisher..Our results demonstrate an approach for direct and specific targeting of oncogenic KRAS in tumours using iExosomes. ..
- Azizan N, Suter M, Liu Y, Logsdon C. RAGE maintains high levels of NF?B and oncogenic Kras activity in pancreatic cancer. Biochem Biophys Res Commun. 2017;493:592-597 pubmed publisher..These observations support the development of approaches to inhibit the carcinogenic actions of Kras indirectly by blocking the mechanisms which maintain its activity. ..
- Langley R, Fan D, Tsan R, Rebhun R, He J, Kim S, et al. Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells. Cancer Res. 2004;64:3727-30 pubmed..The therapeutic combination of STI571 and Taxol may be a powerful tool for targeting tumor-associated endothelial cells in the skeletal compartment. ..
- Tsuda H, Jafar Nejad H, Patel A, Sun Y, Chen H, Rose M, et al. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005;122:633-44 pubmed..Interestingly, loss of Gfi-1 mimics SCA1 phenotypes in Purkinje cells. These results indicate that the Atx-1/Gfi-1 interaction contributes to the selective Purkinje cell degeneration in SCA1. ..
- Chahrour M, Jung S, Shaw C, Zhou X, Wong S, Qin J, et al. MeCP2, a key contributor to neurological disease, activates and represses transcription. Science. 2008;320:1224-9 pubmed publisher..These studies suggest that MeCP2 regulates the expression of a wide range of genes in the hypothalamus and that it can function as both an activator and a repressor of transcription. ..
- Baradia H, Nikahd N, Glasser A. Mouse lens stiffness measurements. Exp Eye Res. 2010;91:300-7 pubmed publisher..This was determined by comparing the average change in lens diameter at various force values used. The two methods provide a good indication of the stiffness properties of mouse lenses. ..
- Ben Ami R, Garcia Effron G, Lewis R, Gamarra S, Leventakos K, Perlin D, et al. Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance. J Infect Dis. 2011;204:626-35 pubmed publisher..albicans in competitive mixed infection models. We conclude that fks1 mutations that confer echinocandin resistance come at fitness and virulence costs, which may limit their epidemiological and clinical impact...
- Poole E, Kubzansky L, Sood A, Okereke O, Tworoger S. A prospective study of phobic anxiety, risk of ovarian cancer, and survival among patients. Cancer Causes Control. 2016;27:661-8 pubmed publisher..Future research should explore the role of phobic anxiety and other forms of psychological distress and ovarian cancer risk and survival. ..
- Ning G, Jurecic V, Baldini A, Xu J. Structure and chromosomal locations of mouse steroid receptor coactivator gene family. In Vitro Cell Dev Biol Anim. 1999;35:481-6 pubmed..This information is important for developing valuable animal models harboring multiple disruptions of the SRC gene family to study their biological functions. ..
- Weeber E, Atkins C, Selcher J, Varga A, Mirnikjoo B, Paylor R, et al. A role for the beta isoform of protein kinase C in fear conditioning. J Neurosci. 2000;20:5906-14 pubmed
- Alexianu M, Kozovska M, Appel S. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology. 2001;57:1282-9 pubmed
- Dumble M, Gatza C, Tyner S, Venkatachalam S, Donehower L. Insights into aging obtained from p53 mutant mouse models. Ann N Y Acad Sci. 2004;1019:171-7 pubmed..One challenge for the future will be to find ways to manipulate p53 function to provide increased cancer resistance, yet still enhance overall organismal longevity. ..
- Takada Y, Aggarwal B. Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling. Blood. 2004;104:4113-21 pubmed..Overall our results show that RANKL signaling is modulated by the TNF receptors and thus provide evidence of cross-talk between the receptors of 2 cytokines. ..
- Koster M, Kim S, Huang J, Williams T, Roop D. TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis. Dev Biol. 2006;289:253-61 pubmed..Our data identify AP-2gamma as the first in vivo target gene of TAp63alpha, and provide novel insights into the molecular mechanisms associated with early events in epidermal morphogenesis. ..
- Wang X, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, et al. MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades. J Immunol. 2011;186:5791-800 pubmed publisher..Finally, we found that MEKK3 activation by TCR stimulation requires Rac1/2. Taken together, our study reveals a specific role of MEKK3 in mediating the TCR signals for IFN-? production. ..
- Lu Y, Hong S, Li H, Park J, Hong B, Wang L, et al. Th9 cells promote antitumor immune responses in vivo. J Clin Invest. 2012;122:4160-71 pubmed publisher..Our data suggest a distinct role for tumor-specific Th9 cells in provoking CD8+ CTL-mediated antitumor immunity and indicate that Th9 cell-based cancer immunotherapy may be a promising therapeutic approach. ..
- Tokonzaba E, Chen J, Cheng X, Den Z, Ganeshan R, Muller E, et al. Plakoglobin as a regulator of desmocollin gene expression. J Invest Dermatol. 2013;133:2732-2740 pubmed publisher..It is tempting to speculate that this shift is required for the invasive growth of placode keratinocytes into the dermis, a crucial step in skin appendage formation. ..
- Glasgow S, Laug D, Brawley V, Zhang Z, Corder A, Yin Z, et al. The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS. J Neurosci. 2013;33:13560-8 pubmed publisher..These studies represent the first characterization of miR-223/NFIA axis function in glioma and demonstrate that it is a conserved proliferative mechanism across CNS development and tumorigenesis...
- Wei Q, Sha Y, Bhattacharya A, Abdel Fattah E, Bonilla D, Jyothula S, et al. Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. Am J Respir Crit Care Med. 2014;189:16-29 pubmed publisher..Our study identified a previously uncharacterized role for STUB1 in regulating IL-4R signaling, which might provide a new strategy for attenuating airway inflammation. ..
- Mack S, Witt H, Piro R, Gu L, Zuyderduyn S, Stütz A, et al. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature. 2014;506:445-50 pubmed publisher..We conclude that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland. ..
- Shum E, Jones S, Shao A, Dumdie J, Krause M, Chan W, et al. The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay. Cell. 2016;165:382-95 pubmed publisher..Mice conditionally lacking UPF3A exhibit "hyper" NMD and display defects in embryogenesis and gametogenesis. Our results support a model in which UPF3A serves as a molecular rheostat that directs developmental events. ..
- Burgess D, Noebels J. Single gene defects in mice: the role of voltage-dependent calcium channels in absence models. Epilepsy Res. 1999;36:111-22 pubmed..A comparative analysis of channel function and neural excitability patterns in tottering, lethargic, and stargazer brain should be useful in identifying the common elements of calcium channel involvement in these absence models. ..
- Burns K, Yan C, Kumar T, Matzuk M. Analysis of ovarian gene expression in follicle-stimulating hormone beta knockout mice. Endocrinology. 2001;142:2742-51 pubmed..Underscoring the usefulness of the FSH-deficient mouse model, this study clarifies aspects of gonadotropin-dependent folliculogenesis, thecal layer development, cycle control in granulosa cells, and luteinization. ..
- Drouin S, Corry D, Kildsgaard J, Wetsel R. Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. J Immunol. 2001;167:4141-5 pubmed..Collectively, these results demonstrate that C3-deficient mice have significantly altered allergic lung responses and indicate a role for the complement system in promoting Th2 effector functions in asthma. ..
- Levasseur R, Barrios R, Elefteriou F, Glass D, Lieberman M, Karsenty G. Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice. Endocrinology. 2003;144:2761-4 pubmed..These results establish the importance of cysteine metabolism for the regulation of bone remodeling and longitudinal growth. ..
- Mok H, Mendoza M, Prchal J, Balogh P, Schumacher A. Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice. Development. 2004;131:4871-81 pubmed..Thus, aberrant Fpn1 regulation and iron homeostasis interferes with development of the spleen stroma during embryogenesis, resulting in a novel defect in spleen architecture postnatally. ..
- Hsieh M, Boerboom D, Shimada M, Lo Y, Parlow A, Luhmann U, et al. Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function. Biol Reprod. 2005;73:1135-46 pubmed..Thus, Fzd4 appears to impact the formation of the corpus luteum by mechanisms that more closely phenocopy Prlr null mice. ..
- Li H, Dutuor A, Tao L, Fu X, Zhang X. Virotherapy with a type 2 herpes simplex virus-derived oncolytic virus induces potent antitumor immunity against neuroblastoma. Clin Cancer Res. 2007;13:316-22 pubmed..We conclude that the ability of FusOn-H2 to induce tumor-specific cellular immunity expands the oncolytic repertoire of this virus and increases the likelihood that its use in patients would produce significant therapeutic benefits. ..
- Lin Y, Liu G, Zhang Y, Hu Y, Yu K, Lin C, et al. Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development. 2007;134:723-34 pubmed
- Wadhwa L, Hurwitz M, Chevez Barrios P, Hurwitz R. Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus. Cancer Res. 2007;67:10653-6 pubmed..036). There were no observed adverse events due to the virus in any of the treated animals. SVV-001 may be effective as a treatment of locally invasive and metastatic retinoblastoma. ..
- Namiranian K, Lloyd E, Crossland R, Marrelli S, Taffet G, Reddy A, et al. Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Am J Physiol Regul Integr Comp Physiol. 2010;299:R461-9 pubmed publisher..There was no sign of TREK-1-like currents in CVSMCs from WT mice, and there were no major differences in currents between the genotypes. We conclude that regulation of arterial diameter is not altered in mice lacking TREK-1. ..
- Rai R, Zheng H, He H, Luo Y, Multani A, Carpenter P, et al. The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J. 2010;29:2598-610 pubmed publisher..Our results reveal that telomeres engage distinct DNA repair pathways depending on how they are rendered dysfunctional, and that A-NHEJ is a major pathway to process dysfunctional telomeres. ..
- Brod S, Bauer V. Ingested (oral) neuropeptide Y inhibits EAE. J Neuroimmunol. 2012;250:44-9 pubmed publisher..Ingested (orally administered) NPY can inhibit clinical disease, inhibit CNS inflammation by decreasing Th17 and Th1-like cytokines and increasing Th2-like cytokines in the CNS. ..
- Chen S, Tao J, Bae Y, Jiang M, Bertin T, Chen Y, et al. Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9. J Bone Miner Res. 2013;28:649-59 pubmed publisher..Hence, Notch negatively regulates chondrocyte differentiation in the axial skeleton by suppressing Sox9 transcription, and Rbpj-independent Notch signaling mechanisms may also contribute to axial skeletogenesis. ..
- Chen M, Wang Y, Wang Y, Huang L, Sandoval H, Liu Y, et al. Dendritic cell apoptosis in the maintenance of immune tolerance. Science. 2006;311:1160-4 pubmed..The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central role for these cells in maintaining immune self-tolerance. ..
- Li H, Choudhary S, Milner D, Munir M, Kuisk I, Capetanaki Y. Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin. J Cell Biol. 1994;124:827-41 pubmed..These data suggested that myogenesis is modulated by at least more than one pathway and desmin, which so far was believed to be merely an architectural protein, seems to play a key role in this process. ..
- Gan L, Xiang M, Zhou L, Wagner D, Klein W, Nathans J. POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci U S A. 1996;93:3920-5 pubmed..In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types. ..
- Ghebranious N, Donehower L. Mouse models in tumor suppression. Oncogene. 1998;17:3385-400 pubmed..In this review, we discuss some of the mechanistic insights provided by tumor suppressor-deficient mice and their utility as models for human cancer syndromes. ..
- Songyang Z, Yamanashi Y, Liu D, Baltimore D. Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling. J Biol Chem. 2001;276:2459-65 pubmed..Our results suggest that Dok oligomerization through its multiple domains plays a critical role in Dok signaling in response to tyrosine kinase activation. ..
- Couroucli X, Welty S, Geske R, Moorthy B. Regulation of pulmonary and hepatic cytochrome P4501A expression in the rat by hyperoxia: implications for hyperoxic lung injury. Mol Pharmacol. 2002;61:507-15 pubmed..In conclusion, our results suggest that induction of CYP1A1 by hyperoxia is mediated by AHR-dependent mechanisms and that modulation of CYP1A enzymes by hyperoxia may have implications for hyperoxic lung injury. ..
- Hentges K, Yarlagadda S, Justice M. Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Genomics. 2002;80:204-12 pubmed..The characterization of these genes in tumor samples will allow a function to be assigned to many novel loci identified by the genome sequencing projects. ..
- Mazumdar A, Kumar R. Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells. FEBS Lett. 2003;535:6-10 pubmed..Together, these results identify a novel signaling pathway linking estrogen action to Pak1 signaling, and Pak1 to FKHR, suggesting that Pak1 is an important mediator of estrogen's cell survival functions. ..
- Guidry T, Olsen M, Kil K, Hunter R, Geng Y, Actor J. Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6'-dimycolate. J Interferon Cytokine Res. 2004;24:362-71 pubmed..These experiments provide evidence for a role for CD1d in mediation of pathology during hypersensitive responses to the mycobacterial glycolipid TDM. ..
- Banko J, Hou L, Klann E. NMDA receptor activation results in PKA- and ERK-dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1. J Neurochem. 2004;91:462-70 pubmed
- Straathof K, Pule M, Yotnda P, Dotti G, Vanin E, Brenner M, et al. An inducible caspase 9 safety switch for T-cell therapy. Blood. 2005;105:4247-54 pubmed..Third, inducible caspase 9 maintains function in T cells overexpressing antiapoptotic molecules. These characteristics favor incorporation of inducible caspase 9 as a safety feature in human T-cell therapies. ..
- Hentges K, Nakamura H, Furuta Y, Yu Y, Thompson D, O BRIEN W, et al. Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr Patterns. 2006;6:653-65 pubmed
- Brunetti Pierri N, Stapleton G, Palmer D, Zuo Y, Mane V, Finegold M, et al. Pseudo-hydrodynamic delivery of helper-dependent adenoviral vectors into non-human primates for liver-directed gene therapy. Mol Ther. 2007;15:732-40 pubmed..Using a low, clinically relevant vector dose, this minimally invasive method results in high-efficiency hepatic transduction with minimal toxicity and stable long-term transgene expression for at least 413 days...
- Chen J, Jaeger K, Den Z, Koch P, Sundberg J, Roop D. Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita. J Invest Dermatol. 2008;128:270-9 pubmed
- Guo X, Deng Y, Lin Y, Cosme Blanco W, Chan S, He H, et al. Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J. 2007;26:4709-19 pubmed..In addition, our results suggest that loss of ATM can cooperate with dysfunctional telomeres to promote cellular transformation and tumor formation in vivo. ..
- Huebener P, Abou Khamis T, Zymek P, Bujak M, Ying X, Chatila K, et al. CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response. J Immunol. 2008;180:2625-33 pubmed..Our findings suggest that CD44-mediated interactions are critically involved in infarct healing. CD44 signaling is important for resolution of the postinfarction inflammatory reaction and regulates fibroblast function. ..
- Hoyos V, Savoldo B, Quintarelli C, Mahendravada A, Zhang M, Vera J, et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety. Leukemia. 2010;24:1160-70 pubmed publisher..In summary, this strategy safely increases the anti-lymphoma/leukemia effects of CAR.19-redirected T lymphocytes and may be a useful approach for treatment of patients with B-cell malignancies. ..
- Fujimoto J, Kadara H, Men T, Van Pelt C, Lotan D, Lotan R. Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice. PLoS ONE. 2010;5:e11847 pubmed publisher..Further experimentation to prove the reliability of the Gprc5a knockout mouse model for the study of tobacco-induced lung carcinogenesis is warranted. ..