Genomes and Genes
Experts and Doctors on mice in Dallas, Texas, United States
Locale: Dallas, Texas, United States
Publications838 found, 100 shown here
- Hojayev B, Rothermel B, Gillette T, Hill J. FHL2 binds calcineurin and represses pathological cardiac growth. Mol Cell Biol. 2012;32:4025-34 pubmed publisher..FHL2 is an endogenous, agonist-dependent suppressor of calcineurin. ..
- Kavalali E, Monteggia L. Synaptic mechanisms underlying rapid antidepressant action of ketamine. Am J Psychiatry. 2012;169:1150-6 pubmed
- Patel V, Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, et al. miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. Proc Natl Acad Sci U S A. 2013;110:10765-70 pubmed publisher..Our results also provide a unique hypothesis for disease progression in PKD involving miRNAs and regulation of PKD gene dosage. ..
- Xin M, Kim Y, Sutherland L, Murakami M, Qi X, McAnally J, et al. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A. 2013;110:13839-44 pubmed publisher..These findings identify Yap as an important regulator of cardiac regeneration and provide an experimental entry point to enhance this process. ..
- Black B, Lu J, Olson E. The MEF2A 3' untranslated region functions as a cis-acting translational repressor. Mol Cell Biol. 1997;17:2756-63 pubmed
- Hasegawa T, Zhao L, Caron K, Majdic G, Suzuki T, Shizawa S, et al. Developmental roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice. Mol Endocrinol. 2000;14:1462-71 pubmed..These studies provide the first systematic evaluation of the developmental consequences of StAR deficiency in the various steroidogenic organs. ..
- Edwards S, Simmons D, Galindo D, Doherty J, Scott A, Hughes P, et al. Antagonistic effects of dopaminergic signaling and ethanol on protein kinase A-mediated phosphorylation of DARPP-32 and the NR1 subunit of the NMDA receptor. Alcohol Clin Exp Res. 2002;26:173-80 pubmed..These data demonstrate antagonistic effects of acute ethanol exposure on D1 signaling in vivo and the potential of acute in vivo challenge protocols to help fill gaps in the understanding of ethanol's effects on protein phosphorylation. ..
- Meredith D, Masui T, Swift G, Macdonald R, Johnson J. Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex. J Neurosci. 2009;29:11139-48 pubmed publisher..Together, these results identify multiple transcriptional mechanisms that control Ptf1a levels, one modulating levels by autoregulation through the PTF1-J complex, and the other a Ptf1a-independent mechanism for initial activation. ..
- Moreira C, Herrera C, Needham B, Parker C, Libby S, Fang F, et al. Virulence and stress-related periplasmic protein (VisP) in bacterial/host associations. Proc Natl Acad Sci U S A. 2013;110:1470-5 pubmed publisher..VisP converges bacterial cell wall homeostasis, stress responses, and pathogenicity. ..
- Parsons W, Richardson J, Graves K, Williams R, Moreadith R. Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart. Proc Natl Acad Sci U S A. 1993;90:1726-30 pubmed
- Li X, Grundy S, Patel S. Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100. J Lipid Res. 1997;38:1277-88 pubmed..Total apoB secreted, however, was not increased. Our data further suggest that the predominant cause of the dyslipidemia under these conditions is a defect in removal of VLDL from the circulation. ..
- Garg V, Kathiriya I, Barnes R, Schluterman M, King I, Butler C, et al. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature. 2003;424:443-7 pubmed..These results implicate GATA4 as a genetic cause of human cardiac septal defects, perhaps through its interaction with TBX5. ..
- Kasus Jacobi A, Ou J, Birch D, Locke K, Shelton J, Richardson J, et al. Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo. J Biol Chem. 2005;280:20413-20 pubmed..We propose that mRDH11 disruption affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptation through modulation of calcium homeostasis. ..
- Kim K, Jo Y, Zhao L, Stallings N, Chua S, Parker K. Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Mol Endocrinol. 2008;22:1950-61 pubmed publisher..These studies suggest that SF-1 directly regulates the expression of CB1R, which has been implicated in the regulation of energy homeostasis and anxiety-like behavior. ..
- Danesh S, Villasenor A, Chong D, Soukup C, Cleaver O. BMP and BMP receptor expression during murine organogenesis. Gene Expr Patterns. 2009;9:255-65 pubmed publisher..Our studies will aid in the future design and/or interpretation of targeted deletion of individual Bmp or Bmpr genes, since this study identifies organs and tissues where redundant BMP signaling pathways are likely to occur. ..
- Le L, Shipman T, Burns D, Parada L. Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell Stem Cell. 2009;4:453-63 pubmed publisher..We also provide evidence that additional signals from nonneoplastic cells in the tumor microenvironment play essential roles in neurofibromagenesis...
- Duan B, Davis R, Sadat E, Collins J, Sternweis P, Yuan D, et al. Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. J Immunol. 2010;185:335-44 pubmed publisher..These results are the first to ascribe specific functions to an AC isoform in the immune system and emphasize the importance of cAMP synthesis by this isoform in shaping the immune responses. ..
- Best A, Chang J, Dull A, Beutler J, Martinez E. Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay. J Biomed Biotechnol. 2011;2011:868095 pubmed publisher..These compounds block the viability of lung cancer and melanoma cells, prevent cell cycle progression, and/or inhibit histone deacetylase activity, altering levels of cellular histone acetylation. ..
- Umetani M, Shaul P. 27-Hydroxycholesterol: the first identified endogenous SERM. Trends Endocrinol Metab. 2011;22:130-5 pubmed publisher..Therefore, 27OHC is the first identified endogenous selective estrogen receptor modulator (SERM) and could have an important impact upon the cardiovascular system, bone biology, and cancer. ..
- Zhu M, Zhang Q, Wang L, Li H, Liu Z. FoxO4 inhibits atherosclerosis through its function in bone marrow derived cells. Atherosclerosis. 2011;219:492-8 pubmed publisher..FoxO4 inhibits atherosclerosis through bone marrow derived cells, possibly by inhibition of ROS and inflammatory cytokines that promote monocyte recruitment and/or retention. ..
- Frost R, Olson E. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A. 2011;108:21075-80 pubmed publisher..Furthermore, our Cre-inducible Let-7-transgenic mice provide a unique model for studying tissue-specific aspects of body growth and type 2 diabetes. ..
- Bottiglieri T, Arning E, Wasek B, Nunbhakdi Craig V, Sontag J, Sontag E. Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain. J Neurosci. 2012;32:9173-81 pubmed publisher..These findings reveal a novel mechanism involving methylation-dependent pathways in L-dopa induces PP2A hypomethylation and increases Tau phosphorylation, which may be potentially detrimental to neuronal cells. ..
- Menon J, Gulaka P, McKay M, Geethanath S, Liu L, Kodibagkar V. Dual-modality, dual-functional nanoprobes for cellular and molecular imaging. Theranostics. 2012;2:1199-207 pubmed publisher..As proof of principle, these nanoprobes were successfully used for fluorescence imaging and for measuring pO(2) changes in cells by magnetic resonance imaging, in vitro, thus showing potential for in vivo applications...
- Raft S, Andrade L, Shao D, Akiyama H, Henkemeyer M, Wu D. Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 2014;390:51-67 pubmed publisher..We propose that developmental dysplasias described here are a gene dose-sensitive cause of the vestibular dysfunction observed in EphB-Efnb2 signaling-deficient mice. ..
- Yun E, Zhou J, Lin C, Hernandez E, Fazli L, Gleave M, et al. Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer. Clin Cancer Res. 2016;22:670-9 pubmed publisher..This new combination therapy strategy targeting CSC could significantly enhance therapeutic efficacy of current chemotherapy regimen only targeting non-CSC cells. ..
- Lee A, De Jesus Cortes H, Kabir Z, Knobbe W, Orr M, Burgdorf C, et al. The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons. Eneuro. 2016;3: pubmed publisher..The role of Cav1.2 in young hippocampal neurons survival may provide new approaches for understanding and treating neuropsychiatric disease associated with aberrations in CACNA1C. Visual Abstract. ..
- Hua X, Wu J, Goldstein J, Brown M, Hobbs H. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics. 1995;25:667-73 pubmed..The SREBF1 gene mapped to the proximal short arm of chromosome 17 (17p11.2), and the SREBF2 gene was localized to the long arm of chromosome 22 (22q13). ..
- Wang C, Lambracht D, Wonigeit K, Howard J, Lindahl K. Rat RT1 orthologs of mouse H2-M class Ib genes. Immunogenetics. 1995;42:63-7 pubmed
- Liebl D, Tessarollo L, Palko M, Parada L. Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci. 1997;17:9113-21 pubmed..We suggest that neurotrophins may function in creating early heterogeneity that would enable ganglia to compensate for diverse modality requirements before the period of naturally occurring death. ..
- Zhu Y, Romero M, Ghosh P, Ye Z, Charnay P, Rushing E, et al. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001;15:859-76 pubmed..These results indicate that NF1-deficient neurons are capable of inducing reactive astrogliosis via a non-cell autonomous mechanism. ..
- Kong Y, Shelton J, Rothermel B, Li X, Richardson J, Bassel Duby R, et al. Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. Circulation. 2001;103:2731-8 pubmed..01). FHL2 is an early marker of cardiogenic cells and a cardiac-specific LIM protein in the adult. FHL2 is not required for normal cardiac development but modifies the hypertrophic response to beta-adrenergic stimulation. ..
- Li S, Garrard W. The kinetics of V-J joining throughout 3.5 megabases of the mouse Ig kappa locus fit a constrained diffusion model of nuclear organization. FEBS Lett. 2003;536:125-9 pubmed..These results fit a model of nuclear organization in which the entire V kappa J kappa region resides within a single nuclear subcompartment and is capable of exhibiting multiple reversible contacts through diffusion and Brownian motion. ..
- Willis M, Carlson D, Dimaio J, White M, White D, Adams G, et al. Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury. Am J Physiol Heart Circ Physiol. 2005;288:H795-804 pubmed..This study is the first to demonstrate that MIF mediates late, prolonged cardiac dysfunction after burn injury and suggests that MIF blockade should be considered a therapeutic target for the treatment of burn injury. ..
- Fondon J, Garner H. Molecular origins of rapid and continuous morphological evolution. Proc Natl Acad Sci U S A. 2004;101:18058-63 pubmed..The high frequency and incremental effects of repeat length mutations provide molecular explanations for swift, yet topologically conservative morphological evolution. ..
- Yu X, Burgess S, Ge H, Wong K, Nassem R, Garry D, et al. Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart. Proc Natl Acad Sci U S A. 2005;102:1767-72 pubmed..This mouse model will be useful to elucidate the role of reduced fatty acid supply in the pathogenesis of heart failure and related disorders. ..
- Romero M, Lin L, Lush M, Lei L, Parada L, Zhu Y. Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. J Neurosci. 2007;27:2124-34 pubmed..This phenomenon appears to be mediated both by a cell-autonomous capacity of spared Nf1-/- DRG neurons for increased axonal sprouting, and by non-cell-autonomous contribution from Nf1-/- neurons in the denervated spinal cord. ..
- Yang W, Li H, Mayhew E, Mellon J, Chen P, Niederkorn J. NKT cell exacerbation of liver metastases arising from melanomas transplanted into either the eyes or spleens of mice. Invest Ophthalmol Vis Sci. 2011;52:3094-102 pubmed publisher..These results suggest that hepatic NKT cell activity can have an important effect in the immune surveillance of liver metastases. ..
- Zhang Y, Blackwell E, McKnight M, Knutsen G, Vu W, Ruest L. Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2. Dev Dyn. 2012;241:924-40 pubmed publisher..To determine the role of Twist1 during mandibular development, we used the Hand2-Cre transgene to conditionally inactivate the gene in the neural crest cells populating the mandibular pharyngeal arch...
- Zhang C, Dai H, de Crombrugghe B. Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx. Biochem Biophys Res Commun. 2012;420:782-6 pubmed publisher..Taken together, these findings support our hypothesis that Dkk1 is a direct target of Osx. ..
- Shin H, Franco L, Nair V, Collins A, Shiloh M. A baculovirus-conjugated mimotope vaccine targeting Mycobacterium tuberculosis lipoarabinomannan. PLoS ONE. 2017;12:e0185945 pubmed publisher..Thus, we report a proof of principle M. tuberculosis vaccination strategy combining an anti-LAM mimotope with a baculovirus delivery system...
- Chubb C. Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. J Androl. 1992;13:312-7 pubmed..The results provide the first evidence that the oligotriche gene mutation induces male mouse sterility by effecting the complete absence of a sperm tail. This phenotypic action is different from that of the quaking gene mutation...
- Chin E, Olson E, Richardson J, Yang Q, Humphries C, Shelton J, et al. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev. 1998;12:2499-509 pubmed..These results identify a molecular mechanism by which different patterns of motor nerve activity promote selective changes in gene expression to establish the specialized characteristics of slow and fast myofibers. ..
- Zhu Y, Richardson J, Parada L, Graff J. Smad3 mutant mice develop metastatic colorectal cancer. Cell. 1998;94:703-14 pubmed..These results directly implicate TGFbeta signaling in the pathogenesis of colorectal cancer and provide a compelling animal model for the study of human colorectal cancer. ..
- Watson M, Zinn A, Inoue N, Hess K, Cobb J, Handel M, et al. Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Proc Natl Acad Sci U S A. 1998;95:14361-6 pubmed..Identification of the gene inactivated by the transgene insertion may define a novel biochemical pathway involved in mammalian germ cell development and meiosis. ..
- Srivastava D. HAND proteins: molecular mediators of cardiac development and congenital heart disease. Trends Cardiovasc Med. 1999;9:11-8 pubmed..Congenital heart disease is considered as a defect in segmental development of the heart and the role of dHAND and eHAND in regulating such developmental pathways in normal and abnormal cardiogenesis is examined. ..
- Posner B, Gilman A, Harris B. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. J Biol Chem. 1999;274:31087-93 pubmed..RGS/beta5 complexes may contribute to the selectivity of signal transduction initiated by receptors coupled to G(i) and G(o) by binding to phospholipase C and stimulating the GTPase activity of Galpha(o). ..
- Janz R, Sudhof T, Hammer R, Unni V, Siegelbaum S, Bolshakov V. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron. 1999;24:687-700 pubmed..Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself. ..
- Yamagishi H, Yamagishi C, Nakagawa O, Harvey R, Olson E, Srivastava D. The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol. 2001;239:190-203 pubmed..5 and dHAND. These studies provide the first demonstration of gene mutations that result in ablation of the entire ventricular segment of the mammalian heart, and reveal essential transcriptional pathways for ventricular formation. ..
- Vakevainen M, Greenberg S, Hansen E. Inhibition of phagocytosis by Haemophilus ducreyi requires expression of the LspA1 and LspA2 proteins. Infect Immun. 2003;71:5994-6003 pubmed..ducreyi are involved, directly or indirectly, in the antiphagocytic activity of this pathogen, and they provide a possible explanation for the greatly reduced virulence of the lspA1 lspA2 mutant...
- McDaniel L, Chester N, Watson M, Borowsky A, Leder P, Schultz R. Chromosome instability and tumor predisposition inversely correlate with BLM protein levels. DNA Repair (Amst). 2003;2:1387-404 pubmed
- Hao Z, Duncan G, Chang C, Elia A, Fang M, Wakeham A, et al. Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell. 2005;121:579-591 pubmed publisher..These studies indicate the existence of a Cyt c- and apoptosome-independent but Apaf-1-dependent mechanism(s) for caspase activation. ..
- Pieper A, Wu X, Han T, Estill S, Dang Q, Wu L, et al. The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice. Proc Natl Acad Sci U S A. 2005;102:14052-7 pubmed..We propose that a deficiency in adult neurogenesis may cause the behavioral and neuroanatomical abnormalities seen in Npas3-/- mice, and we speculate that impaired neurogenesis may be involved in the pathophysiology of schizophrenia. ..
- Gemelli T, Berton O, Nelson E, Perrotti L, Jaenisch R, Monteggia L. Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice. Biol Psychiatry. 2006;59:468-76 pubmed..These data highlight the important role of MeCP2 in the forebrain and suggest that even partial loss of MeCP2 expression in these brain regions is sufficient to recapitulate features of RTT. ..
- Castillero Trejo Y, Eliazer S, Xiang L, Richardson J, Ilaria R. Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors. Cancer Res. 2005;65:8698-705 pubmed..This Ewing sarcoma animal model will be a useful tool for dissecting the molecular pathogenesis of Ewing sarcoma and provides rationale for the broader use of organ-specific progenitor cell populations for the study of human sarcoma. ..
- Niederkorn J, Stevens C, Mellon J, Mayhew E. Differential roles of CD8+ and CD8- T lymphocytes in corneal allograft rejection in 'high-risk' hosts. Am J Transplant. 2006;6:705-13 pubmed..Either CD8+ or CD8 T cells can produce corneal allograft rejection, however functional FasL is necessary for optimal rejection, even in a high-risk setting. ..
- Sun Y, Prasad M, Gao T, Wang X, Zhu Q, D SOUZA R, et al. Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. J Biol Chem. 2010;285:31713-22 pubmed publisher..These results indicate that the full-length form of DMP1 is an inactive precursor and its proteolytic processing is an activation step essential to the biological functions of this protein in osteogenesis. ..
- Patrick D, Montgomery R, Qi X, Obad S, Kauppinen S, Hill J, et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest. 2010;120:3912-6 pubmed publisher..We therefore conclude that miR-21 is not essential for pathological cardiac remodeling. ..
- Bhoj E, Ramos P, Baker L, Garg V, Cost N, Nordenskjold A, et al. Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development. Eur J Hum Genet. 2011;19:540-6 pubmed publisher..The association of BNC2 disruption with distal urethral defects and the gene's expression pattern indicate that it functions in urethral development. ..
- Zhang Y, Knutsen G, Brown M, Ruest L. Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2. Mol Endocrinol. 2013;27:892-908 pubmed publisher..Together these results indicate that progesterone regulates Ednra expression by synergizing with Gata2 activity, a previously unknown mechanism. This mechanism may have an impact on pathologies involving the endothelin signaling. ..
- Stallings N, Puttaparthi K, Dowling K, Luther C, Burns D, Davis K, et al. TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis. PLoS ONE. 2013;8:e71793 pubmed publisher..These results indicate that levels of TDP-43 regulate body fat composition and glucose homeostasis in vivo. ..
- Abid S, Xie S, Bose M, Shaul P, Terada L, Brody S, et al. 17?-Estradiol Dysregulates Innate Immune Responses to Pseudomonas aeruginosa Respiratory Infection and Is Modulated by Estrogen Receptor Antagonism. Infect Immun. 2017;85: pubmed publisher..aeruginosa ER-mediated processes may explain the sex-based mortality gap in CF and other inflammatory lung illnesses, and the ER blockade represents a rational therapeutic strategy. ..
- Baynash A, Hosoda K, Giaid A, Richardson J, Emoto N, Hammer R, et al. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell. 1994;79:1277-85 pubmed..These findings indicate that interaction of EDN3 with the endothelin-B receptor is essential in the development of neural crest-derived cell lineages. We postulate that defects in the human EDN3 gene may cause Hirschsprung's disease. ..
- Kedzierski W, Lloyd M, Birch D, Bok D, Travis G. Generation and analysis of transgenic mice expressing P216L-substituted rds/peripherin in rod photoreceptors. Invest Ophthalmol Vis Sci. 1997;38:498-509 pubmed..These mice may thus be considered an animal model for this disease. ..
- Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci U S A. 2001;98:13710-5 pubmed..These results thus reveal mechanisms for regulation of ChREBP and the L-PK transcription by excess carbohydrate and cAMP. ..
- Zhao G, Chen Y, Liu X, Xu Z, Qi X. Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis. Dev Biol. 2001;240:212-22 pubmed..These indicate that, similar to Bmp8a, Bmp7 plays a role in both the maintenance of spermatogenesis and epididymal function and it further suggests that BMP8 and BMP7 signal through the same or similar receptors in these two systems. ..
- German D, Liang C, Song T, Yazdani U, Xie C, Dietschy J. Neurodegeneration in the Niemann-Pick C mouse: glial involvement. Neuroscience. 2002;109:437-50 pubmed..The activation of astrocytes in regions that undergo neurodegeneration is also consistent with a role for these glial cells in the neurodegenerative process. ..
- Chen G, Liang G, Ou J, Goldstein J, Brown M. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A. 2004;101:11245-50 pubmed..Nuclear SREBPs and nuclear factor Y play permissive roles. ..
- Wang Y, Soyombo A, Shcheynikov N, Zeng W, Dorwart M, Marino C, et al. Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J. 2006;25:5049-57 pubmed..These findings reveal the intricate regulation of CFTR activity by slc26a6 in both the resting and stimulated states and the essential role of slc26a6 in pancreatic HCO(3)(-) secretion in vivo...
- Nishibu A, Ward B, Boes M, Takashima A. Roles for IL-1 and TNFalpha in dynamic behavioral responses of Langerhans cells to topical hapten application. J Dermatol Sci. 2007;45:23-30 pubmed..Motile activities of epidermal LCs are reprogrammed by selected cytokines known to be produced by keratinocytes under pathological conditions. ..
- Battiste J, Helms A, Kim E, Savage T, Lagace D, Mandyam C, et al. Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development. 2007;134:285-93 pubmed..Furthermore, Ascl1-null cells in the spinal cord have a diminished capacity to undergo neuronal differentiation, with a subset of these cells retaining characteristics of immature glial cells. ..
- Peng T, Huang B, Sun Y, Lu Y, Bonewald L, Chen S, et al. Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells Tissues Organs. 2009;189:192-7 pubmed publisher..Data from transfection analysis indicated that this substitution completely prevented formation of the GAG-containing form, confirming that DMP1-PG contains a single GAG chain attached to Ser(89) in mouse DMP1. ..
- Maximov A, Tang J, Yang X, Pang Z, Sudhof T. Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science. 2009;323:516-21 pubmed publisher..Thus, complexin probably activates and clamps the force transfer from assembled trans-SNARE complexes onto fusing membranes. ..
- Cortés V, Curtis D, Sukumaran S, Shao X, Parameswara V, Rashid S, et al. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 2009;9:165-76 pubmed publisher..These observations suggest that both dietary fat and hepatic triglyceride biosynthesis via a monoacylglycerol pathway may contribute to hepatic steatosis in Agpat2(-/-) mice. ..
- Hutcheson J, Perlman H. BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. Oncogene. 2008;27 Suppl 1:S168-75 pubmed publisher..We also suggest a role for BH3-mimetic drugs as potential therapeutics in the treatment of RA. ..
- Gao Z, Ure K, Ables J, Lagace D, Nave K, Goebbels S, et al. Neurod1 is essential for the survival and maturation of adult-born neurons. Nat Neurosci. 2009;12:1090-2 pubmed publisher..Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons. ..
- Mayer P, Huang N, Dewey C, Dries D, Zhang H, Yu G. Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem. 2010;285:40387-96 pubmed publisher..These studies show that Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway. ..
- Liu N, Bezprozvannaya S, Shelton J, Frisard M, Hulver M, McMillan R, et al. Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy. J Clin Invest. 2011;121:3258-68 pubmed publisher..Our findings reveal an essential role for miR-133a in the maintenance of adult skeletal muscle structure, function, bioenergetics, and myofiber identity; they also identify a potential modulator of centronuclear myopathies. ..
- Du Y, An S, Liu L, Li L, Zhou X, Mason R, et al. Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imaging. PLoS ONE. 2012;7:e43941 pubmed publisher..The LI-COR IRDye® 800CW RGD optical probe (RGD probe) is a NIR fluorophore, that can target integrin alpha v beta 3 (?(v)?(3)) in tissues...
- Zhang C, Tang W, Li Y. Matrix metalloproteinase 13 (MMP13) is a direct target of osteoblast-specific transcription factor osterix (Osx) in osteoblasts. PLoS ONE. 2012;7:e50525 pubmed publisher..Taken together, these data strongly support a direct regulatory role for Osx in MMP13 gene expression in osteoblasts. They further provide new insight into potential mechanisms and pathways that Osx controls bone formation. ..
- Patel A, Hays S, Bureau I, Huber K, Gibson J. A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons. J Neurosci. 2013;33:2593-604 pubmed publisher..These changes may contribute to the cognitive dysfunction and circuit hyperexcitability associated with Fragile X syndrome, including patients with complete deletion of FMRP and those with mosaic expression of FMRP. ..
- Zang T, Maksimova M, Cowan C, Bassel Duby R, Olson E, Huber K. Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Mol Cell Neurosci. 2013;56:39-49 pubmed publisher..Our findings suggest that FMRP and MEF2 function together to fine tune synapse formation and elimination rates in response to neuronal activity levels over the course of postnatal development. ..
- Gao D, Wu J, Wu Y, Du F, Aroh C, Yan N, et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science. 2013;341:903-6 pubmed publisher..These results indicate that cGAS is an innate immune sensor of HIV and other retroviruses. ..
- Fernando W, Martins A, Zhao P, Wu Y, Kiefer G, Platas Iglesias C, et al. Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents. Inorg Chem. 2016;55:3007-14 pubmed publisher..The advantages of such systems are demonstrated experimentally both in vitro and in vivo and DFT calculations were performed to help understand the physical-chemical reasons for this interesting behavior. ..
- Lin Q, Schwarz J, Bucana C, Olson E. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997;276:1404-7 pubmed..Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development. ..