Experts and Doctors on membrane proteins in Houston, Texas, United States


Locale: Houston, Texas, United States
Topic: membrane proteins

Top Publications

  1. Takashima H, Boerkoel C, De Jonghe P, Ceuterick C, Martin J, Voit T, et al. Periaxin mutations cause a broad spectrum of demyelinating neuropathies. Ann Neurol. 2002;51:709-15 pubmed
    ..Our study indicates a prominent sensory neuropathy resulting from periaxin gene mutations and suggests a role for the carboxyl terminal domain of the periaxin protein. ..
  2. Youssef E, Chen X, Higuchi E, Kondo Y, Garcia Manero G, Lotan R, et al. Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. Cancer Res. 2004;64:2411-7 pubmed
    ..These findings indicate that silencing of TIG1 promoter by hypermethylation is common in human cancers and may contribute to the loss of retinoic acid responsiveness in some neoplastic cells. ..
  3. Hu X, Kim J, Castillo A, Huang M, Liu J, Wang B. NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes. J Biol Chem. 2011;286:11734-45 pubmed publisher
    ..Together, these studies reveal critical interactions required for the formation and function of BRCC36-containing DUB complexes. ..
  4. Reiter L, Murakami T, Koeuth T, Gibbs R, Lupski J. The human COX10 gene is disrupted during homologous recombination between the 24 kb proximal and distal CMT1A-REPs. Hum Mol Genet. 1997;6:1595-603 pubmed
    ..We propose that the distal CMT1A-REP represents the progenitor copy of COX10 exon VI which was duplicated with surrounding intronic sequences during mammalian genome evolution and that the HNPP deletion results in a COX10 null allele. ..
  5. Li D, Burch P, Gonzalez O, Kashork C, Shaffer L, Bachinski L, et al. Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. Biochem Biophys Res Commun. 2000;274:117-23 pubmed
    ..All of them have been defined as WD-repeat proteins. Therefore, WDR6 is a novel protein and probably belongs to a highly conserved subfamily of WD-repeat proteins in which T7B11.12 and YPL183c are its distantly related members. ..
  6. Tangjitgamol S, Ramirez P, Sun C, See H, Jhingran A, Kavanagh J, et al. Expression of HER-2/neu, epidermal growth factor receptor, vascular endothelial growth factor, cyclooxygenase-2, estrogen receptor, and progesterone receptor in small cell and large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathol. Int J Gynecol Cancer. 2005;15:646-56 pubmed
    ..03). There was a trend toward worse survival in patients with EGFR expression, but this finding was not significant. The combination of negative HER-2/neu expression and positive EGFR expression had the worst impact on survival. ..
  7. Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, et al. EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell. 2012;48:771-84 pubmed publisher
    ..These findings highlight the distinct regulation of NF-κB by EGF, in contrast to TNF-α, and the importance of the metabolic cooperation between the EGFR and NF-κB pathways in PKM2 upregulation and tumorigenesis. ..
  8. Rothnagel J, Longley M, Bundman D, Naylor S, Lalley P, Jenkins N, et al. Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3. Genomics. 1994;23:450-6 pubmed
    ..These mouse mutants exhibit a number of changes in their integument, suggesting that abnormalities in these genes may contribute to the mutant phenotype. ..
  9. Sampson M, Lovell R, Craigen W. The murine voltage-dependent anion channel gene family. Conserved structure and function. J Biol Chem. 1997;272:18966-73 pubmed
    ..VDAC3, however, is only able to partially complement the mutant phenotype, suggesting an alternative physiologic function for the VDAC3 protein. ..

More Information

Publications366 found, 100 shown here

  1. Cho K, Chern J, Izaddoost S, Choi K. Novel signaling from the peripodial membrane is essential for eye disc patterning in Drosophila. Cell. 2000;103:331-42 pubmed
    ..Furthermore, PM cells extend cellular processes to the DP. Therefore, peripodial signaling is critical for eye pattern formation and may be mediated by peripodial processes. ..
  2. Liu W, Ahmad S, Jung Y, Reinmuth N, Fan F, Bucana C, et al. Coexpression of ephrin-Bs and their receptors in colon carcinoma. Cancer. 2002;94:934-9 pubmed
    ..Further studies are necessary to determine the functional role of ephrin-Bs in colon carcinoma angiogenesis and growth. ..
  3. Choi H, Batsakis J, Zhan F, Sturgis E, Luna M, El Naggar A. Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis. Hum Pathol. 2002;33:158-64 pubmed
  4. Kirchhoff S, Gupta S, Knowlton A. Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation. 2002;105:2899-904 pubmed
    ..These results support a key antiapoptotic role for cytosolic HSP60. To our knowledge, this is the first report suggesting that interactions of HSP60 with bax and/or bak regulate apoptosis. ..
  5. Cunningham S, Rodriguez J, Arrate M, Tran T, Brock T. JAM2 interacts with alpha4beta1. Facilitation by JAM3. J Biol Chem. 2002;277:27589-92 pubmed
  6. Chu K, Tsai M. Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes. 2005;54:1064-73 pubmed
    ..These results suggest for the first time an important role for NNAT in insulin secretion and for proper beta-cell function. ..
  7. Lin Lee Y, Pham L, Tamayo A, Fu L, Zhou H, Yoshimura L, et al. Nuclear localization in the biology of the CD40 receptor in normal and neoplastic human B lymphocytes. J Biol Chem. 2006;281:18878-87 pubmed
  8. Shiomi D, Margolin W. The C-terminal domain of MinC inhibits assembly of the Z ring in Escherichia coli. J Bacteriol. 2007;189:236-43 pubmed
    ..These results suggest that the C-terminal half of MinC has an additional function in the regulation of Z-ring assembly. ..
  9. Scott K, Chin L. Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis. Clin Cancer Res. 2010;16:2229-34 pubmed publisher
    ..Understanding how these processes may be deregulated and contribute to cancer pathogenesis and drug response will uncover new avenues for therapeutic intervention. ..
  10. Pedram A, Razandi M, Lewis M, HAMMES S, Levin E. Membrane-localized estrogen receptor ? is required for normal organ development and function. Dev Cell. 2014;29:482-90 pubmed publisher
    ..We conclude that many organs require membrane ER? and resulting signal transduction to collaborate with nuclear ER? for normal development and function. ..
  11. Vinish M, Cui W, Stafford E, Bae L, Hawkins H, Cox R, et al. Dendritic cells modulate burn wound healing by enhancing early proliferation. Wound Repair Regen. 2016;24:6-13 pubmed publisher
    ..Therefore, pharmacological enhancement of DCs may provide a therapeutic intervention to facilitate healing of burn wounds. ..
  12. O Neal W, Hasty P, McCray P, Casey B, Rivera Perez J, Welsh M, et al. A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus. Hum Mol Genet. 1993;2:1561-9 pubmed
    ..Thus, an additional mouse model for CF has been generated that should prove useful for the understanding of the pathogenesis and the development of treatments for CF. ..
  13. Yu X, Weihe E, Margolin W. Role of the C terminus of FtsK in Escherichia coli chromosome segregation. J Bacteriol. 1998;180:6424-8 pubmed
    ..When the truncated ftsK was combined with a minCDE deletion, chains of minicells were generated, many of which contained DNA. These results suggest that the C terminus of FtsK has an important role in chromosome partitioning. ..
  14. Hassan B, Bermingham N, He Y, Sun Y, Jan Y, Zoghbi H, et al. atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron. 2000;25:549-61 pubmed
    ..In contrast to its function in the PNS, ato does not act as a proneural gene in the embryonic brain. Instead, ato performs a novel function, regulating arborization during larval and pupal development by interacting with Notch. ..
  15. Vorburger S, Pataer A, Yoshida K, Liu Y, Lu X, Swisher S, et al. The mitochondrial apoptosis-inducing factor plays a role in E2F-1-induced apoptosis in human colon cancer cells. Ann Surg Oncol. 2003;10:314-22 pubmed
  16. Koh T, Verstreken P, Bellen H. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron. 2004;43:193-205 pubmed
    ..Our data suggest that Dap160, like dynamin, is involved in synaptic vesicle retrieval at active and periactive zones. ..
  17. Singh B, Berry J, Shoher A, Ramakrishnan V, Lucci A. COX-2 overexpression increases motility and invasion of breast cancer cells. Int J Oncol. 2005;26:1393-9 pubmed
    ..In this study, we conclude that COX-2 overexpression in human breast cancer cells enhances cell motility and invasiveness thus suggesting a mechanism of COX-2 mediated metastasis. ..
  18. Wang Johanning F, Liu J, Rycaj K, Huang M, Tsai K, Rosen D, et al. Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer. Int J Cancer. 2007;120:81-90 pubmed
    ..HERV env proteins, and especially those expressed on the cell surface, may serve as novel tumor targets for detection, diagnosis and immunotherapy of ovarian cancer. ..
  19. Moore D. Physiology. Sister act. Science. 2007;316:1436-8 pubmed
  20. Flanagan J, Sheehan V, Linder H, Howard T, Wang Y, HOPPE C, et al. Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia. Blood. 2013;121:3237-45 pubmed publisher
    ..These mutations were discovered and validated by an unbiased whole-genome approach, and future studies will focus on how these functional mutations may lead to protection from stroke in the context of SCA. ..
  21. Giagtzoglou N, Li T, Yamamoto S, Bellen H. Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. J Cell Sci. 2013;126:3686-96 pubmed publisher
    ..In conclusion, dEHBP1 provides developmental versatility of intercellular signaling by regulating the trafficking of distinct Notch signaling components. ..
  22. McNew J, Sondermann H, Lee T, Stern M, Brandizzi F. GTP-dependent membrane fusion. Annu Rev Cell Dev Biol. 2013;29:529-50 pubmed publisher
    ..Here, we review recent advances in our functional and molecular understanding of fusion DRPs, exemplified by atlastin, an ER-resident DRP that controls ER structure, function, and signaling. ..
  23. Day F, Thompson D, Helgason H, Chasman D, Finucane H, Sulem P, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet. 2017;49:834-841 pubmed publisher
    ..In aggregate, our findings highlight the complexity of the genetic regulation of puberty timing and support causal links with cancer susceptibility. ..
  24. Mills A, Zheng B, Wang X, Vogel H, Roop D, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999;398:708-13 pubmed
    ..Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis...
  25. Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh A, Bucana C, et al. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am J Pathol. 2003;163:1001-11 pubmed
    ..02). Our results suggest that autocrine activation of the IGF-IR system significantly affects VEGF expression and angiogenesis in human pancreatic cancer. Thus, IGF-IR may be a valid target in the treatment of pancreatic cancer. ..
  26. Gee J, Montoya R, Khaled H, Sabichi A, Grossman H. Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. Urol Oncol. 2003;21:266-70 pubmed
    ..CK20, AN43 and PGDH decreased but COX-2 expression increased in higher stage tumors. The histologic phenotype of these cancers is reflected in their expression of these proteins and is modified further as tumors progress in stage. ..
  27. Chung A, Xu X, Niederreither K, Cooney A. Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer. Dev Biol. 2006;293:13-24 pubmed
    ..Increased cell death may contribute to the loss of midbrain structure in GCNF-/- embryos. These results indicate that GCNF is required for establishment of the isthmic organizer, thereby regulating the midbrain development. ..
  28. Ravandi F, Jilani I, Estey E, Kantarjian H, Dey A, Aguilar C, et al. Soluble phosphorylated fms-like tyrosine kinase III. FLT3 protein in patients with acute myeloid leukemia (AML). Leuk Res. 2007;31:791-7 pubmed
    ..04). Other mechanisms may be responsible for abnormal phosphorylation of FLT3 and inhibitors of FLT3 should also be investigated in patients without mutations. ..
  29. Wensel T. Signal transducing membrane complexes of photoreceptor outer segments. Vision Res. 2008;48:2052-61 pubmed publisher
  30. Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, et al. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem. 2010;285:30598-605 pubmed publisher
    ..Our results establish an essential function of the conserved APP intracellular domain in developmental regulation, and this activity can be genetically uncoupled from APP processing and A? pathogenesis. ..
  31. Srinivasan S, Deng W, Li R. L-selectin transmembrane and cytoplasmic domains are monomeric in membranes. Biochim Biophys Acta. 2011;1808:1709-15 pubmed publisher
    ..This study will provide constraints for future investigations on the interaction of L-selectin and its associating proteins. ..
  32. Lee J, Jiffar T, Kupferman M. A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma. PLoS ONE. 2012;7:e30246 pubmed publisher
    ..These results suggest BDNF/TrkB system plays critical roles in CDDP-resistance development by utilizing Akt-dependent signaling pathways. ..
  33. Kwong L, Davies M. Targeted therapy for melanoma: rational combinatorial approaches. Oncogene. 2014;33:1-9 pubmed publisher
    ..In this review, we will discuss the preclinical and clinical studies that are testing leading hypotheses and emerging combinatorial strategies for the future. ..
  34. DiSepio D, Jones A, Longley M, Bundman D, Rothnagel J, Roop D. The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression. J Biol Chem. 1995;270:10792-9 pubmed
    ..5-kilobase genomic fragment, and those elements required to restrict expression to differentiated keratinocytes lie outside this region. ..
  35. Yvon E, Vigouroux S, Rousseau R, Biagi E, Amrolia P, Dotti G, et al. Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood. 2003;102:3815-21 pubmed
    ..Notch activation in the presence of alloantigen-presenting cells may therefore be a means of inducing specific regulatory T cells while preserving other T-cell functionality. ..
  36. Verstreken P, Ly C, Venken K, Koh T, Zhou Y, Bellen H. Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron. 2005;47:365-78 pubmed
    ..Our data suggest a specific role for mitochondria in regulating synaptic strength. ..
  37. Morris A, Tawil A, Berkova Z, Wible L, Smith C, Cunningham S. Junctional Adhesion Molecules (JAMs) are differentially expressed in fibroblasts and co-localize with ZO-1 to adherens-like junctions. Cell Commun Adhes. 2006;13:233-47 pubmed
    ..We conclude that endogenous JAM-C is an integral component of the dermal fibroblast adherens-like junction, and our data extend the expression and potential function of JAMs into mesenchymal tissues. ..
  38. Abu Elheiga L, Brinkley W, Zhong L, Chirala S, Woldegiorgis G, Wakil S. The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci U S A. 2000;97:1444-9 pubmed
  39. Sharma S, Davidson A. Vanadate-induced trapping of nucleotides by purified maltose transport complex requires ATP hydrolysis. J Bacteriol. 2000;182:6570-6 pubmed
    ..ATP hydrolysis is therefore necessary, but not sufficient, for vanadate-induced nucleotide trapping...
  40. Takada Y, Aggarwal B. Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. J Immunol. 2003;171:3278-86 pubmed
    ..This may provide a molecular basis for the ability of BA to mediate apoptosis, suppress inflammation, and modulate the immune response. ..
  41. Chen M, Huang L, Wang J. Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. Blood. 2007;109:4360-7 pubmed
    ..Our data suggest that Bim is important for regulating spontaneous cell death in DCs, and Bim-deficient DCs may contribute to the development of autoimmune diseases in Bim(-/-) mice. ..
  42. Wong L. Pathogenic mitochondrial DNA mutations in protein-coding genes. Muscle Nerve. 2007;36:279-93 pubmed
  43. Yamaguchi H, Chen C, Chou C, Pal A, Bornmann W, Hortobagyi G, et al. Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation. Oncogene. 2010;29:5619-29 pubmed publisher
    ..Together, our results provide not only a novel insight into the mechanisms underlying anti-tumor activity of E1A, but also a rationale for the combined HDACi and E1A gene therapy in future clinical trials. ..
  44. Zou S, Pita Almenar J, Eskin A. Regulation of glutamate transporter GLT-1 by MAGI-1. J Neurochem. 2011;117:833-40 pubmed publisher
    ..These data suggest that MAGI-1 regulates surface expression of GLT-1 and the level of glutamate in the hippocampus. ..
  45. Bogdanov M, Dowhan W, Vitrac H. Lipids and topological rules governing membrane protein assembly. Biochim Biophys Acta. 2014;1843:1475-88 pubmed publisher
    ..This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey. ..
  46. Endsley M, Somasunderam A, Li G, Oezguen N, Thiviyanathan V, Murray J, et al. Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain. Virology. 2014;454-455:60-6 pubmed publisher
    ..Thus, these studies suggest ADAM10 as a novel therapeutic target for inhibiting HIV-1 prior to nuclear entry. ..
  47. Castellano A, Wei X, Birnbaumer L, Perez Reyes E. Cloning and expression of a neuronal calcium channel beta subunit. J Biol Chem. 1993;268:12359-66 pubmed
  48. McDonnell T, Beham A, Sarkiss M, Andersen M, Lo P. Importance of the Bcl-2 family in cell death regulation. Experientia. 1996;52:1008-17 pubmed
    ..The mechanism(s) by which bcl-2 family members regulate cell death remain in large part unknown, although recent evidence suggests that bcl-2 may interfere with cellular signalling events involved in apoptosis induction. ..
  49. Kontoyiannis D. Efflux-mediated resistance to fluconazole could be modulated by sterol homeostasis in Saccharomyces cerevisiae. J Antimicrob Chemother. 2000;46:199-203 pubmed
    ..These results reinforce the emerging evidence in both S. cerevisiae and Candida albicans that sterols could serve as substrates for Pdr5p for transport across membranes...
  50. Yang Q, Bermingham N, Finegold M, Zoghbi H. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science. 2001;294:2155-8 pubmed
    ..The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment...
  51. Xia X, Wang P, Sun X, Soriano S, Shum W, Yamaguchi H, et al. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A. 2002;99:8760-5 pubmed
    ..Further, by measuring the levels of endogenous Abeta(X-40) and Abeta(X-42) in primary neuronal cultures, we confirmed the concept that PS1 is indispensable for the production of secreted Abeta. ..
  52. Zhang Y, Lin Y, Bowles C, Wang F. Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2. J Biol Chem. 2004;279:55348-54 pubmed
  53. Lee J, Madrid R, Sperle K, Ritterson C, Hobson G, Garbern J, et al. Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect. Ann Neurol. 2006;59:398-403 pubmed
    ..Our observations suggest that genomic rearrangements that do not include PLP1 coding sequences should be considered as yet another potential mutational mechanism underlying PLP1-related dysmyelinating disorders. ..
  54. Sasaki J, Phillips B, Chen X, Van Eps N, Tsai A, Hubbell W, et al. Different dark conformations function in color-sensitive photosignaling by the sensory rhodopsin I-HtrI complex. Biophys J. 2007;92:4045-53 pubmed publisher
  55. Yu X, Lu N, Zhou Z. Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells. PLoS Biol. 2008;6:e61 pubmed publisher
  56. Zhang J, Liu J, Huang Y, Chang J, Liu L, McKeehan W, et al. FRS2?-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circ Res. 2012;110:e29-39 pubmed publisher
    ..The findings provide the first evidence that autophagy plays a role in heart progenitor differentiation. ..
  57. Reynolds J, Chiang D, Wang W, Beavers D, Dixit S, Skapura D, et al. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013;100:44-53 pubmed publisher
    ..In particular, JPH2 may be critical in anchoring the invaginating sarcolemma to the sarcoplasmic reticulum, thereby enabling the maturation of the TT network. ..
  58. Moayedi Y, Basch M, Pacheco N, Gao S, Wang R, Harrison W, et al. The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs. PLoS Genet. 2014;10:e1004055 pubmed publisher
    ..Our work is one of the first studies to suggest that a putative splicing factor has specific effects on Notch signaling pathway members and inner ear development. ..
  59. Mohamed J, Huang W, Nallapareddy S, Teng F, Murray B. Influence of origin of isolates, especially endocarditis isolates, and various genes on biofilm formation by Enterococcus faecalis. Infect Immun. 2004;72:3658-63 pubmed publisher
    ..faecalis regulator) [corrected] resulted in fewer attached bacteria, as determined using phase-contrast microscopy, and less biofilm (P < 0.0001)...
  60. Jiang Y, Li X, Yang W, Hawke D, Zheng Y, Xia Y, et al. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell. 2014;53:75-87 pubmed publisher
    ..These findings highlight the role of PKM2 as a protein kinase controlling the fidelity of chromosome segregation, cell-cycle progression, and tumorigenesis. ..
  61. Sherry D, Wang M, Frishman L. Differential distribution of vesicle associated membrane protein isoforms in the mouse retina. Mol Vis. 2003;9:673-88 pubmed
    ..VAMP-1 is a specific marker for a set of large ganglion cells and displaced ganglion cells that ramify in the mid-IPL and are likely to have ON-OFF physiology...
  62. Arun B, Kilic G, Yen C, Foster B, Yardley D, Gaynor R, et al. Loss of FHIT expression in breast cancer is correlated with poor prognostic markers. Cancer Epidemiol Biomarkers Prev. 2005;14:1681-5 pubmed
    ..Furthermore, loss of FHIT expression is also seen in metastatic axillary lymph node. The prognostic and predictive value of these findings needs to be further evaluated in larger trials with longer follow-up. ..
  63. Babcock D, Shi S, Jo J, Shaw M, Gutstein H, Galko M. Hedgehog signaling regulates nociceptive sensitization. Curr Biol. 2011;21:1525-33 pubmed publisher
    ..We demonstrate a novel physiological role for Hh signaling, which has not previously been implicated in nociception. Our results also identify new potential therapeutic targets for pain treatment. ..
  64. Bradfute S, Graubert T, Goodell M. Roles of Sca-1 in hematopoietic stem/progenitor cell function. Exp Hematol. 2005;33:836-43 pubmed
    ..In addition, mouse Sca-1 overexpression affects human as well as mouse stem/progenitor cell activity, suggesting the possibility of a functional human Sca-1 homologue. ..
  65. Vasudevan S, Shang X, Shang X, Chang S, Ge N, Diaz Miron J, et al. Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma. Mol Cancer Ther. 2009;8:2478-89 pubmed publisher
    ..Furthermore, NDSP serves as a growth factor for neuroblastoma tumor cells through activation of the ERK-mediated proliferation pathway. ..
  66. Nguyen P, Silberg J. A selection that reports on protein-protein interactions within a thermophilic bacterium. Protein Eng Des Sel. 2010;23:529-36 pubmed publisher
    ..This selection increases the maximum temperature where a PCA can be used to engineer thermostable protein complexes and to map protein-protein interactions...
  67. Braverman N, Raymond G, Rizzo W, Moser A, Wilkinson M, Stone E, et al. Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines. Mol Genet Metab. 2016;117:313-21 pubmed publisher
  68. Ding Z, Babensee J, Simon S, Lu H, Perrard J, Bullard D, et al. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol. 1999;163:5029-38 pubmed
    ..Neutrophil extravasation in response to TNF-alpha in LFA-1-deficient mice dramatically decreased, whereas neutrophil extravasation in Mac-1-deficient mice markedly increased. ..
  69. Van Dyke M, Nelson L, Weilbaecher R, Mehta D. Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae. J Biol Chem. 2004;279:24323-33 pubmed
    ..We discuss the implications of our findings in relation to prior genetic, genomic, and proteomic studies that have identified STM1 and/or Stm1p as well as the possible biological role of Stm1p. ..
  70. Hammond D, Becker J, Elliott T, Holubee K, Baker T, Love J. Antigenic protein in microgravity-grown human mixed Mullerian ovarian tumor (LN1) cells preserved in RNA stabilizing agent. Gravit Space Biol Bull. 2005;18:99-100 pubmed
  71. Qi H, Li D, Shine H, Chen Z, Yoon K, Jones D, et al. Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Exp Eye Res. 2008;86:34-40 pubmed
    ..The spatial expression of NGF and TrkA by small clusters of basal cells interspersed between negative cell patches suggests that they are potential markers for human corneal epithelial progenitor cells...
  72. Anto R, Mukhopadhyay A, Shishodia S, Gairola C, Aggarwal B. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002;23:1511-8 pubmed
    ..Overall, our results indicate that through phosphorylation and degradation of IkappaB(alpha), CSC can activate NF-kappaB in a wide a variety of cells, and this may play a role in CS-induced carcinogenesis. ..
  73. Herz H, Woodfield S, Chen Z, Bolduc C, Bergmann A. Common and distinct genetic properties of ESCRT-II components in Drosophila. PLoS ONE. 2009;4:e4165 pubmed publisher
    ..Our data redefine the role of Notch for hyperplastic and neoplastic overgrowth in these mutants. While Notch is required for hyperplastic growth, it appears to be dispensable for neoplastic transformation. ..
  74. Henary H, Hong D, Falchook G, Tsimberidou A, George G, Wen S, et al. Melanoma patients in a phase I clinic: molecular aberrations, targeted therapy and outcomes. Ann Oncol. 2013;24:2158-65 pubmed publisher
    ..For melanoma patients, especially those with BRAF mutations, administering molecularly matched agents can be associated with better outcomes, including longer PFS compared with their first-line systemic therapy. ..
  75. Zhou Y, Maxwell K, Sezgin E, Lu M, Liang H, Hancock J, et al. Bile acids modulate signaling by functional perturbation of plasma membrane domains. J Biol Chem. 2013;288:35660-70 pubmed publisher
    ..These observations suggest general, membrane-mediated mechanisms by which biological amphiphiles can produce their cellular effects. ..
  76. Lin Y, Deng H, Ruan K. Topology of catalytic portion of prostaglandin I(2) synthase: identification by molecular modeling-guided site-specific antibodies. Arch Biochem Biophys. 2000;379:188-97 pubmed
  77. Vasudevan S, Russell H, Okcu M, Burlingame S, Liu Z, Yang J, et al. Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma. J Pediatr Surg. 2007;42:148-52 pubmed
    ..From these data, we conclude that NDSP mRNA levels in neuroblastoma tumor tissue correlate with risk group assignment and may serve as a marker for metastasis in bone marrow. ..
  78. Meng J, Fang B, Liao Y, Chresta C, Smith P, Roth J. Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim. PLoS ONE. 2010;5:e13026 pubmed publisher
    ..These results have implications in the development of strategies to overcome resistance to MEK inhibitors. ..
  79. Ruiz M, Egal H, Sarthy V, Qian X, Sarkar H. Cloning, expression, and localization of a mouse retinal gamma-aminobutyric acid transporter. Invest Ophthalmol Vis Sci. 1994;35:4039-48 pubmed
    ..The mouse retinal GAT-1 cDNA encodes a Na(+)-dependent, high-affinity GABA transporter that is mainly expressed in a subset of mouse retinal inter neurons. ..
  80. Creighton C, Li X, Landis M, Dixon J, Neumeister V, Sjolund A, et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A. 2009;106:13820-5 pubmed publisher
    ..Targeting proteins involved in EMT may provide a therapeutic strategy for eliminating surviving cells to prevent recurrence and improve long-term survival in breast cancer patients...
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