Experts and Doctors on lymphocyte activation in Dallas, Texas, United States

Summary

Locale: Dallas, Texas, United States
Topic: lymphocyte activation

Top Publications

  1. Motta Mena L, Smith S, Mallory M, Jackson J, Wang J, Lynch K. A disease-associated polymorphism alters splicing of the human CD45 phosphatase gene by disrupting combinatorial repression by heterogeneous nuclear ribonucleoproteins (hnRNPs). J Biol Chem. 2011;286:20043-53 pubmed publisher
    ..Therefore, these studies provide an important example of the functional relevance of combinatorial function in splicing regulation and suggest that additional polymorphisms may similarly disrupt function of the ESS1 silencer. ..
  2. Akiyoshi H, Chung J, Tomihari M, Cruz P, Ariizumi K. Depleting syndecan-4+ T lymphocytes using toxin-bearing dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand: a new opportunity for treating activated T cell-driven disease. J Immunol. 2010;184:3554-61 pubmed publisher
    ..Our results provide a strong rationale for exploring use of toxin-conjugated DC-HIL to treat activated T cell-driven disease in humans. ..
  3. Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore A, et al. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity. 2017;46:818-834.e4 pubmed publisher
    ..On the basis of these and previous observations, we propose that the E-Id protein axis specifies innate and adaptive lymphoid cell fate. ..
  4. Chiang E, Stroynowski I. Protective immunity against disparate tumors is mediated by a nonpolymorphic MHC class I molecule. J Immunol. 2005;174:5367-74 pubmed
  5. Tennakoon D, Mehta R, Ortega S, Bhoj V, Racke M, Karandikar N. Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis. J Immunol. 2006;176:7119-29 pubmed
    ..These studies not only explain several prior observations relating to the mechanism of this drug but also provide important insights into the natural immune interplay underlying this human immune-mediated disease. ..
  6. Ren H, Schmalstieg A, Yuan D, Gaynor R. I-kappa B kinase beta is critical for B cell proliferation and antibody response. J Immunol. 2002;168:577-87 pubmed
    ..These results suggest that IKKbeta is critical for the proliferation of B cells and the control of some aspects of the humoral response. ..
  7. Nguyen K, Miller B. CD28 costimulation induces delta opioid receptor expression during anti-CD3 activation of T cells. J Immunol. 2002;168:4440-5 pubmed
    ..It also appears that costimulatory receptors other than CD28 can provide the signaling required for delta OR expression because delta OR mRNA was induced by Con A stimulation of splenocytes from CD28-deficient mice. ..
  8. Yin W, Gorvel L, Zurawski S, Li D, Ni L, Duluc D, et al. Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells. EBioMedicine. 2016;5:46-58 pubmed publisher
    ..This study provides fundamental information for the rational design of vaccines against cancers and viral infections. ..
  9. Yang W, Chen P, Li H, Alizadeh H, Niederkorn J. PD-L1: PD-1 interaction contributes to the functional suppression of T-cell responses to human uveal melanoma cells in vitro. Invest Ophthalmol Vis Sci. 2008;49:2518-25 pubmed publisher
    ..The selective blockade of PD-L1 is a potential strategy in T-cell-based immunotherapy for uveal melanoma. ..

More Information

Publications80

  1. Pastor S, Vaccaro C, Minguela A, Ober R, Ward E. Analyses of TCR clustering at the T cell-antigen-presenting cell interface and its impact on the activation of naive CD4+ T cells. Int Immunol. 2006;18:1615-25 pubmed
    ..Efficient activation can also be achieved in the absence of micrometer-scale TCR clustering, indicating that this is not a prerequisite for the effective stimulation of naive T cells. ..
  2. Pillai V, Ortega S, Wang C, Karandikar N. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol. 2007;123:18-29 pubmed
  3. Matsushima H, Tanaka H, Mizumoto N, Takashima A. Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells. Blood. 2009;114:64-73 pubmed publisher
  4. Harp C, Lovett Racke A, Racke M, Frohman E, Monson N. Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis. Clin Immunol. 2008;128:382-91 pubmed publisher
    ..CNS-antigen specific CD8(+) T cell proliferation was also blocked by HLA-DR, suggesting that CD8(+) proliferation is in part dependent on CD4(+) help. ..
  5. Niederkorn J, Chen P, Mellon J, Stevens C, Mayhew E. Allergic conjunctivitis exacerbates corneal allograft rejection by activating Th1 and th2 alloimmune responses. J Immunol. 2010;184:6076-83 pubmed publisher
    ..Thus, exacerbation of corneal allograft rejection in mice with AC is associated with a mixed Th1 and Th2 alloimmune response, and the contribution of Th1 cells is through their production of IFN-gamma...
  6. Persky M, Murphy K, Farrar J. IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene. J Immunol. 2005;174:294-301 pubmed
  7. Evans J, Cravens P, Gatlin J, Kelly P, Lipsky P, Garcia J. Pre-clinical evaluation of an in vitro selection protocol for the enrichment of transduced CD34+ cell-derived human dendritic cells. Gene Ther. 2001;8:1427-35 pubmed
    ..Thus, MLV-based vectors and in vitro selection of transduced human DC show great promise for immunotherapy protocols. ..
  8. Yu C, Becker C, Wang Y, Marches F, Helft J, Leboeuf M, et al. Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-?. Immunity. 2013;38:818-30 pubmed publisher
    ..Thus, CD1c(+) and CD141(+) DCs generate CD8(+) T cells with different properties, and CD1c(+) DCs specialize in the regulation of mucosal CD8(+) T cells. ..
  9. Lovett Racke A, Hussain R, Northrop S, Choy J, Rocchini A, Matthes L, et al. Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease. J Immunol. 2004;172:5790-8 pubmed
    ..These results suggest that PPAR alpha agonists such as gemfibrozil and fenofibrate, may be attractive candidates for use in human inflammatory conditions such as multiple sclerosis. ..
  10. Halcomb K, Musuka S, Gutierrez T, Wright H, Satterthwaite A. Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells. Mol Immunol. 2008;46:233-41 pubmed publisher
    ..Thus, Btk is required for the initial loss of tolerance to DNA and the subsequent production of pathogenic autoantibodies once tolerance is breached. ..
  11. Topp J, Jackson J, Melton A, Lynch K. A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4. RNA. 2008;14:2038-49 pubmed publisher
    ..Together, these data establish that hnRNP LL plays a critical and unique role in the signal-induced regulation of CD45 and demonstrate the utility of cell-based screens for the identification of novel splicing regulatory factors. ..
  12. Singleton K, Roybal K, Sun Y, Fu G, Gascoigne N, van Oers N, et al. Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009;2:ra15 pubmed publisher
    ..In support of this, the effective clustering of a group of ligand-engaged receptors and signaling intermediates in a joint pattern consistently correlated with efficient T cell activation at the level of the whole cell. ..
  13. Benson A, Murray S, Divakar P, Burnaevskiy N, Pifer R, Forman J, et al. Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism. J Immunol. 2012;188:800-10 pubmed publisher
    ..These results demonstrate that the transient reduction in Treg cells induced by pathogens via IL-2 deprivation is essential for optimal T cell responses and host resistance to microbial and viral pathogens. ..
  14. Tong A, Nguyen J, Lynch K. Differential expression of CD45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons. J Biol Chem. 2005;280:38297-304 pubmed
    ..Together these studies reveal common themes in the regulation of the CD45 variable exons and provide a mechanistic explanation for the observed physiological expression of CD45 isoforms. ..
  15. Xu C, Fillmore C, Koyama S, Wu H, Zhao Y, Chen Z, et al. Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell. 2014;25:590-604 pubmed publisher
    ..TPCs in the LP model and NGFR(+) cells in human SCCs highly expressed Pd-ligand-1 (PD-L1), suggesting a mechanism of immune escape for TPCs. ..
  16. Morris M, Liu J, Arora V, George T, Klem J, Schatzle J, et al. B6 strain Ly49I inhibitory gene expression on T cells in FVB.Ly49IB6 transgenic mice fails to prevent normal T cell functions. J Immunol. 2002;169:3661-6 pubmed
    ..These data are in contrast with findings in Ly49A, and Ly49G2 receptor transgenic models. Perhaps Ly49I-H2(b) interactions are weaker or of lower avidity than Ly49A-H-2D(d) interactions, especially in T cells. ..
  17. Mooney J, Klem J, Wulfing C, Mijares L, Schwartzberg P, Bennett M, et al. The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression. J Immunol. 2004;173:3953-61 pubmed
    ..This predominant inhibitory function of murine 2B4 correlates with increased 2B4 long isoform level expression over 2B4 short. ..
  18. Tao L, Reese T. Making Mouse Models That Reflect Human Immune Responses. Trends Immunol. 2017;38:181-193 pubmed publisher
    ..Consideration of these environmental exposures of both humans and mice can potentially improve mouse models of human disease. ..
  19. Wandstrat A, Nguyen C, Limaye N, Chan A, Subramanian S, Tian X, et al. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity. 2004;21:769-80 pubmed
    ..While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes...
  20. Chujo D, Foucat E, Nguyen T, Chaussabel D, Banchereau J, Ueno H. ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adults. PLoS ONE. 2013;8:e55595 pubmed publisher
    ..This strategy is applicable to determine the differences in the quality of antigen-specific T cells between health and disease. ..
  21. Cao T, Ueno H, Glaser C, Fay J, Palucka A, Banchereau J. Both Langerhans cells and interstitial DC cross-present melanoma antigens and efficiently activate antigen-specific CTL. Eur J Immunol. 2007;37:2657-67 pubmed
    ..Thus, this study provides the rationale to use CD34-DC loaded with necrotic/apoptotic allogeneic melanoma cells in a clinical trial. ..
  22. Subramanian S, Yim Y, Liu K, Tus K, Zhou X, Wakeland E. Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb. J Immunol. 2005;175:1062-72 pubmed
    ..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene. ..
  23. Brown G, Lane G, Whittington B. Disparate role of LIGHT in organ-specific donor T cells activation and effector molecules in MHC class II disparate GVHD. J Clin Immunol. 2010;30:178-84 pubmed publisher
    ..LIGHT inhibition differentially affects cytokines and effector molecules in SpC, small intestines, and large intestines, implicating different organ-specific pathways. ..
  24. Lee J, Sinkovits R, Mock D, Rab E, Cai J, Yang P, et al. Components of the antigen processing and presentation pathway revealed by gene expression microarray analysis following B cell antigen receptor (BCR) stimulation. BMC Bioinformatics. 2006;7:237 pubmed
  25. Grammer A, McFarland R, Heaney J, Darnell B, Lipsky P. Expression, regulation, and function of B cell-expressed CD154 in germinal centers. J Immunol. 1999;163:4150-9 pubmed
    ..These results indicate that CD154 is expressed by human B cells in vivo and plays an important role in mediating B cell responses. ..
  26. Reimold A, Kim J, Finberg R, Glimcher L. Decreased immediate inflammatory gene induction in activating transcription factor-2 mutant mice. Int Immunol. 2001;13:241-8 pubmed
    ..ATF-2 is essential for maximal immediate induction of adhesion molecules and cytokine genes, but at later time points may even protect against overactive immune responses. ..
  27. Mandraju R, Murray S, Forman J, Pasare C. Differential ability of surface and endosomal TLRs to induce CD8 T cell responses in vivo. J Immunol. 2014;192:4303-15 pubmed publisher
    ..Our results have important implications for combined bacterial and viral infections and suggest that bacterial infections could constrain the ability of the host to mount effective antiviral CD8 T cell immunity. ..
  28. Singleton K, Gosh M, Dandekar R, Au Yeung B, Ksionda O, Tybulewicz V, et al. Itk controls the spatiotemporal organization of T cell activation. Sci Signal. 2011;4:ra66 pubmed publisher
    ..Together, these data illustrate how control of the spatiotemporal organization of T cell signaling controls critical aspects of T cell function. ..
  29. Ganesan S, Luu T, Chambers B, Meinke S, Brodin P, Vivier E, et al. The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education. Scand J Immunol. 2017;86:135-142 pubmed publisher
    ..We conclude that signalling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse. ..
  30. Diab A, Deng C, Smith J, Hussain R, Phanavanh B, Lovett Racke A, et al. Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2002;168:2508-15 pubmed
    ..These results suggest that PPAR-gamma ligands may be a novel therapeutic agent for diseases such as multiple sclerosis. ..
  31. Becker A, Blevins J, Tomson F, Eitson J, Medeiros J, Yarovinsky F, et al. Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs. J Immunol. 2010;184:6822-32 pubmed publisher
    ..burgdorferi. These findings indicate that a full complement of functional CD3 zeta ITAMs is required for effective iNKT cell development. ..
  32. Sato K, Shikano S, Xia G, Takao J, Chung J, Cruz P, et al. Selective expression of vacuolar H+-ATPase subunit d2 by particular subsets of dendritic cells among leukocytes. Mol Immunol. 2006;43:1443-53 pubmed
    ..These results indicated that d2 is a new marker for DC and it may, co-operatively with subunit a isoforms, regulate V-ATPase activity. ..
  33. Hao Z, Duncan G, Chang C, Elia A, Fang M, Wakeham A, et al. Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell. 2005;121:579-591 pubmed publisher
    ..These studies indicate the existence of a Cyt c- and apoptosome-independent but Apaf-1-dependent mechanism(s) for caspase activation. ..
  34. Deford Watts L, Dougall D, Belkaya S, Johnson B, Eitson J, Roybal K, et al. The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011;186:6839-47 pubmed publisher
    ..Such findings demonstrate a novel functional role for CD3 ? BRS-phosphoinositide interactions in supporting T cell activation. ..
  35. D Orazio T, Mayhew E, Niederkorn J. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1. J Immunol. 2001;166:26-32 pubmed
  36. Tskvitaria Fuller I, Seth A, Mistry N, Gu H, Rosen M, Wulfing C. Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization. J Immunol. 2006;177:1708-20 pubmed
    ..This result suggests that Cdc42 activity in specific locations at specific times is most critical for its function in T cell activation. ..
  37. Liu K, Li Q, Yu Y, Liang C, Subramanian S, Zeng Z, et al. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes Immun. 2007;8:634-45 pubmed
    ..Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity...
  38. Chung J, Dougherty I, Cruz P, Ariizumi K. Syndecan-4 mediates the coinhibitory function of DC-HIL on T cell activation. J Immunol. 2007;179:5778-84 pubmed
    ..We conclude that SD-4 is the T cell ligand through which DC-HIL mediates its negative coregulatory function. ..
  39. Mahaffey C, Mummert M. Hyaluronan synthesis is required for IL-2-mediated T cell proliferation. J Immunol. 2007;179:8191-9 pubmed
    ..Our results strongly suggest that HA synthesized by T cells themselves is critical for their IL-2-mediated proliferation and have revealed a previously unrecognized role for endogenous HA in T cell biology. ..
  40. Kusuhara M, Matsue K, Edelbaum D, Loftus J, Takashima A, Matsue H. Killing of naive T cells by CD95L-transfected dendritic cells (DC): in vivo study using killer DC-DC hybrids and CD4(+) T cells from DO11.10 mice. Eur J Immunol. 2002;32:1035-43 pubmed
    ..Our data also uncover two major limitations (relatively low homing efficiency and incomplete elimination of Ag-reactive T cells) that remain to be overcome for clinical application of CD95L-transduced DC strategy. ..
  41. Ashour H, Niederkorn J. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol. 2006;176:5950-7 pubmed
    ..These results suggest that peripheral tolerance induced through the eye requires Ag-presenting B cells that simultaneously present Ags on both MHC class I and II molecules...
  42. Fairhurst A, Hwang S, Wang A, Tian X, Boudreaux C, Zhou X, et al. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol. 2008;38:1971-8 pubmed publisher
    ..However, the resolution of TLR7 up-regulation did not eliminate the enhanced humoral autoimmunity observed in B6.SleYaa, suggesting that additional elements in the translocation may contribute to the disease phenotype. ..
  43. Tomihari M, Chung J, Akiyoshi H, Cruz P, Ariizumi K. DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells. Cancer Res. 2010;70:5778-87 pubmed publisher
    ..As such, the DC-HIL/SD-4 pathway is a potentially useful target for antimelanoma immunotherapy...
  44. Roybal K, Buck T, Ruan X, Cho B, Clark D, Ambler R, et al. Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016;9:rs3 pubmed publisher
    ..Thus, we have developed and validated an approach to quantify protein distributions in time and space for the analysis of complex regulatory systems. ..
  45. Chung J, Sato K, Dougherty I, Cruz P, Ariizumi K. DC-HIL is a negative regulator of T lymphocyte activation. Blood. 2007;109:4320-7 pubmed
    ..We conclude that endogenous DC-HIL is a negative regulator of T lymphocyte activation, and that this native inhibitory function can be blocked by exogenous DC-HIL, leading to enhanced immune responses. ..
  46. Liang H, Reich C, Pisetsky D, Lipsky P. The role of surface ig binding in the activation of human B cells by phosphorothioate oligodeoxynucleotides. Scand J Immunol. 2001;54:551-63 pubmed
    ..Together, these results indicate that sODNs engage surface Ig by charge-charge interactions that lead to activation of human B cells. ..
  47. Ren H, Schmalstieg A, van Oers N, Gaynor R. I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function. J Immunol. 2002;168:3721-31 pubmed
    ..These results suggest that IKKalpha and IKKbeta have distinct roles in regulating thymocyte function. ..
  48. Yuan D, Dang T, Hawley J, Jenuwein T, Grosschedl R. Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation. Int Immunol. 1995;7:1163-72 pubmed
    ..These results indicate that different mechanisms may be involved in the activation of resting versus in vivo stimulated B lymphocytes. The findings are discussed in relation to the phenotype described for Oct-2-deficient mice. ..
  49. Jego G, Palucka A, Blanck J, Chalouni C, Pascual V, Banchereau J. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity. 2003;19:225-34 pubmed
    ..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses. ..
  50. Wilder J, Yuan D. Regulation of IFN-gamma mRNA production in murine natural killer cells. Int Immunol. 1995;7:575-82 pubmed
    ..Our results also suggest that induction of the factor which stabilizes the mRNA, although as yet unknown, requires new RNA synthesis. ..
  51. Seaman M, Wang C, Forman J. MHC class Ib-restricted CTL provide protection against primary and secondary Listeria monocytogenes infection. J Immunol. 2000;165:5192-201 pubmed
    ..Together, these data demonstrate that class Ib-restricted CTL play an important role in clearing a primary LM infection and generate a memory population capable of providing significant protection against subsequent infection. ..
  52. Duluc D, Gannevat J, Anguiano E, Zurawski S, Carley M, Boreham M, et al. Functional diversity of human vaginal APC subsets in directing T-cell responses. Mucosal Immunol. 2013;6:626-38 pubmed publisher
    ..To evoke desired types of adaptive immune responses in the human vagina, antigens may need to be targeted to proper APC subsets with right adjuvants. ..
  53. Klem J, Verrett P, Kumar V, Schatzle J. 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function. J Immunol. 2002;169:55-62 pubmed
    ..However, we have also shown that LAT association alone is not sufficient for maximal 2B4 activation. ..
  54. Chung J, Bonkobara M, Tomihari M, Cruz P, Ariizumi K. The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses. Eur J Immunol. 2009;39:965-74 pubmed publisher
    ..Our findings indicate that the DC-HIL/SD-4 pathway can be manipulated to treat T-cell-driven disorders in humans. ..
  55. Chung J, Cruz P, Ariizumi K. Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity. Eur J Immunol. 2011;41:1794-9 pubmed publisher
    ..These findings indicate that SD-4 is unique among known T-cell coinhibitors, in employing CD148 to inhibit T-cell activation at a site distal from the synapse. ..
  56. Harp C, Ireland S, Davis L, Remington G, Cassidy B, Cravens P, et al. Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-? production in response to myelin basic protein and myelin oligodendrocyte glycoprotein. Eur J Immunol. 2010;40:2942-56 pubmed publisher
    ..Our results demonstrate for the first time that the memory B-cell pool in RRMS harbors neuro-Ag specific B cells that can activate T cells...
  57. Catalina M, Carroll M, Arizpe H, Takashima A, Estess P, Siegelman M. The route of antigen entry determines the requirement for L-selectin during immune responses. J Exp Med. 1996;184:2341-51 pubmed
  58. Aguila M, Rodriguez A, Aguila Mansilla H, Lee W. Somatostatin antisense oligodeoxynucleotide-mediated stimulation of lymphocyte proliferation in culture. Endocrinology. 1996;137:1585-90 pubmed
  59. Gao N, Jennings P, Yuan D. Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes. Int Immunol. 2008;20:645-57 pubmed publisher
    ..This in vitro analysis provides a mechanistic basis for understanding the documented NK cell effects on T-independent B cell responses in vivo. ..
  60. Fairhurst A, Mathian A, Connolly J, Wang A, Gray H, George T, et al. Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice. Eur J Immunol. 2008;38:1948-60 pubmed publisher
    ..In summary, the predominant impact of systemic IFN-alpha in this murine model is an exacerbation of mechanisms mediating end organ damage. ..
  61. Seaman M, Perarnau B, Lindahl K, Lemonnier F, Forman J. Response to Listeria monocytogenes in mice lacking MHC class Ia molecules. J Immunol. 1999;162:5429-36 pubmed
    ..Thus, class Ia-deficient animals have a CD8+ T cell repertoire capable of recognizing both class Ia and class Ib molecules and can generate protective immunity to LM. ..
  62. Stepp S, Dufourcq Lagelouse R, Le Deist F, Bhawan S, Certain S, Mathew P, et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science. 1999;286:1957-9 pubmed
    ..Thus, defects in perforin are responsible for 10q21-22-linked FHL. Perforin-based effector systems are, therefore, involved not only in the lysis of abnormal cells but also in the down-regulation of cellular immune activation. ..
  63. Seabra M, Brown M, Goldstein J. Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. Science. 1993;259:377-81 pubmed
    ..The data imply the existence of multiple component A proteins, one of which is missing in choroideremia...
  64. Wulfing C, Tskvitaria Fuller I, Burroughs N, Sjaastad M, Klem J, Schatzle J. Interface accumulation of receptor/ligand couples in lymphocyte activation: methods, mechanisms, and significance. Immunol Rev. 2002;189:64-83 pubmed
    ..In the investigation of NK cell/target cell interactions, we characterize the often tentative NK cell/target cell couple maintenance, as it creates a major obstacle in studying receptor/ligand accumulation. ..
  65. Raetz M, Hwang S, Wilhelm C, Kirkland D, Benson A, Sturge C, et al. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells. Nat Immunol. 2013;14:136-42 pubmed publisher
    ..gondii infection identified the T cell-intrinsic TLR pathway as a major regulator of IFN-? production in CD4(+) T cells responsible for Paneth cell death, dysbiosis and intestinal immunopathology...
  66. Deng C, Radu C, Diab A, Tsen M, Hussain R, Cowdery J, et al. IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity. J Immunol. 2003;170:2833-42 pubmed
    ..These findings may also help explain the association between antecedent infection and the development or exacerbations of some autoimmune diseases. ..
  67. Chung J, Shiue L, Duvic M, Pandya A, Cruz P, Ariizumi K. Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface. Blood. 2011;117:3382-90 pubmed publisher
    ..Finally, we showed toxin-conjugated DC-HIL to abrogate the ability of SS cells to proliferate in vitro. These findings indicate that SD-4 bearing distinct HS moieties plays a pathogenic role in SS and may be targeted for treatment...
  68. Chiang E, Stroynowski I. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol. 2004;173:4394-401 pubmed
    ..Collectively, these studies demonstrate that a MHC class Ib molecule can serve as a restriction element for antitumor CTL and mediate protective immune responses in a syngeneic setting...
  69. Singleton K, Parvaze N, Dama K, Chen K, Jennings P, Purtic B, et al. A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse. J Immunol. 2006;177:4402-13 pubmed
    ..Based on this characterization, we speculate that the T cell invagination, aided by CD2 enrichment, internalizes parts of the TCR signaling machinery to reset T cell signaling upon agonist-mediated, stable APC contact. ..
  70. Di Pucchio T, Chatterjee B, Smed Sorensen A, Clayton S, Palazzo A, Montes M, et al. Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol. 2008;9:551-7 pubmed publisher
    ..Our data demonstrate that pDCs use 'ready-made' stores of MHC class I to rapidly present exogenous antigen to CD8+ T cells. ..
  71. Yang W, Li H, Chen P, Alizadeh H, He Y, Hogan R, et al. PD-L1 expression on human ocular cells and its possible role in regulating immune-mediated ocular inflammation. Invest Ophthalmol Vis Sci. 2009;50:273-80 pubmed publisher
    ..To assess the expression of PD-L1 and PD-L2 on human ocular cells and their potential to regulate ocular inflammation...