Experts and Doctors on intracellular signaling peptides and proteins in Dallas, Texas, United States


Locale: Dallas, Texas, United States
Topic: intracellular signaling peptides and proteins

Top Publications

  1. Chelstowska A, Liu Z, Jia Y, Amberg D, Butow R. Signalling between mitochondria and the nucleus regulates the expression of a new D-lactate dehydrogenase activity in yeast. Yeast. 1999;15:1377-91 pubmed
    ..Our data thus provide gene assignments for two previously unrecognized D-lactate dehydrogenase activities in yeast. ..
  2. Cousin S, Hugl S, Myers M, White M, Reifel Miller A, Rhodes C. Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediate. Biochem J. 1999;344 Pt 3:649-58 pubmed
    ..The additive effect of rGH and IGF-1 on glucose-dependent beta-cell proliferation is therefore reflective of rGH and IGF-1 activating distinctly different mitogenic signalling pathways in beta-cells with minimal crosstalk between them. ..
  3. Sekito T, Thornton J, Butow R. Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol Biol Cell. 2000;11:2103-15 pubmed
    ..Our data show that Rtg1p acts as both a positive and negative regulator of the retrograde response and that Rtg2p acts to transduce mitochondrial signals affecting the phosphorylation state and subcellular localization of Rtg3p. ..
  4. Guaragnella N, Butow R. ATO3 encoding a putative outward ammonium transporter is an RTG-independent retrograde responsive gene regulated by GCN4 and the Ssy1-Ptr3-Ssy5 amino acid sensor system. J Biol Chem. 2003;278:45882-7 pubmed publisher
    ..We propose that ATO3 is induced in rhoo cells to eliminate the excess ammonia that arises because of a potential defect in ammonia assimilation in those cells...
  5. Abe M, Ho C, Kamm K, Grinnell F. Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction. J Biol Chem. 2003;278:47707-12 pubmed
    ..LPA-dependent, Rho kinase-independent force generation also was detected during fibroblast spreading on collagen-coated coverslips. ..
  6. Liu Z, Sekito T, Spirek M, Thornton J, Butow R. Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol Cell. 2003;12:401-11 pubmed
    ..Point mutations in the Rtg2p ATP binding domain simultaneously block RS and Mks1p-Rtg2p interaction. We propose that activation of RS via mitochondrial dysfunction and TOR inhibition intersect at the Rtg2p-Mks1p switch. ..
  7. Chen W, Yazicioglu M, Cobb M. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. J Biol Chem. 2004;279:11129-36 pubmed
    ..Replacement of threonine 84 with glutamate reduced the activation of PAK1 by an active form of the small G protein Cdc42, suggesting that phosphorylation by OSR1 modulates the G protein sensitivity of PAK isoforms. ..
  8. Luikart B, Nef S, Virmani T, Lush M, Liu Y, Kavalali E, et al. TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J Neurosci. 2005;25:3774-86 pubmed
    ..We conclude that TrkB signaling has a cell-autonomous role required for normal development of both presynaptic and postsynaptic components of the Schaffer collateral synapse. ..
  9. Korpanty G, Grayburn P, Shohet R, Brekken R. Targeting vascular endothelium with avidin microbubbles. Ultrasound Med Biol. 2005;31:1279-83 pubmed
    ..We conclude that Av-PESDA-MBs represent a novel and attractive tool to conjugate MBs with biotinylated mAbs for the purposes of vascular targeting and molecular imaging. ..

More Information

Publications117 found, 100 shown here

  1. Lazrak A, Liu Z, Huang C. Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A. 2006;103:1615-20 pubmed
    ..Thus, KS-WNK1 is a physiological antagonist of long WNK1. Hyperkalemia in PHA II patients with PHA II mutations may be caused, at least partially, by increased expression of long WNK1 with or without decreased expression of KS-WNK1. ..
  2. Gong Y, Lee J, Brown M, Goldstein J, Ye J. Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Natl Acad Sci U S A. 2006;103:6154-9 pubmed
    ..These studies identify a single amino acid residue that is crucial for the function of Insig proteins in regulating cholesterol homeostasis in mammalian cells. ..
  3. Chen W, Chen Y, Xu B, Juang Y, Stippec S, Zhao Y, et al. Regulation of a third conserved phosphorylation site in SGK1. J Biol Chem. 2009;284:3453-60 pubmed publisher
    ..SGK1 activation was further augmented by coexpression with the protein kinase WNK1 (with no lysine kinase 1). These findings reveal further complexity underlying the regulation of SGK1 activity. ..
  4. Singh D, Ku C, Wichaidit C, Steininger R, Wu L, Altschuler S. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010;6:369 pubmed publisher
    ..Our results suggest that patterns of signaling heterogeneity, characterized as ensembles of a small number of distinct phenotypic states, can reveal functional differences among cellular populations. ..
  5. Rivera L, Brekken R. SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-?1 activity. J Cell Biol. 2011;193:1305-19 pubmed publisher
    ..These results demonstrate that SPARC promotes pericyte migration by diminishing TGF-? activity and identify a novel function for endoglin in controlling pericyte behavior. ..
  6. Skaug B, Chen J, Du F, He J, Ma A, Chen Z. Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell. 2011;44:559-71 pubmed publisher
    ..Our results suggest a noncatalytic mechanism of IKK inhibition by A20 and a means by which polyubiquitin chains can specify a signaling outcome. ..
  7. Cui H, Sohn J, Gautron L, Funahashi H, Williams K, Elmquist J, et al. Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area. J Comp Neurol. 2012;520:4168-83 pubmed publisher
    ..Our findings provide new insights into MC4R signaling in the LHA and its potential implications in homeostatic regulation of body energy balance. ..
  8. Faulkner R, Nguyen A, Jo Y, DeBose Boyd R. Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells. J Lipid Res. 2013;54:1011-22 pubmed publisher
    ..Together, these results establish Drosophila S2 cells as a model system to elucidate mechanisms through which lipid constituents of cell membranes (i.e., sterols and fatty acids) modulate the ERAD of Insig-1 and reductase. ..
  9. Lee J, Gong Y, Zhang X, Ye J. Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines. Proc Natl Acad Sci U S A. 2006;103:4958-63 pubmed
    ..The current studies indicate that the degradation of ubiquitinated Insigs is controlled by serine residues flanking the sites of ubiquitination. ..
  10. Zhang Y, Lee K, Kinch L, Clark L, Grishin N, Rosenbaum D, et al. Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS. J Biol Chem. 2016;291:12888-96 pubmed publisher
    ..Point mutations that disrupt the Loop1-Loop7 interaction prevented secretion of the Loop1-Loop7 fusion protein. These data provide direct documentation of intramolecular Loop1-Loop7 binding, a central event in cholesterol homeostasis. ..
  11. Rhee S, Grinnell F. P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. J Cell Biol. 2006;172:423-32 pubmed
    ..These findings establish a unified framework for understanding the cell signaling pathways involved in fibroblast contraction of floating collagen matrices. ..
  12. Lutter M, Krishnan V, Russo S, Jung S, McClung C, Nestler E. Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci. 2008;28:3071-5 pubmed publisher
    ..Together, these data indicate that orexin plays an essential role in mediating reduced depression-like symptoms induced by calorie restriction. ..
  13. Yabe D, Xia Z, Adams C, Rawson R. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols. Proc Natl Acad Sci U S A. 2002;99:16672-7 pubmed publisher
    ..Thus, three different point mutations, each within the sterol-sensing domain of SCAP, prevent sterol-induced binding of SCAP to insig proteins and abolish feedback regulation of SREBP processing by sterols...
  14. Vega R, Rothermel B, Weinheimer C, Kovacs A, Naseem R, Bassel Duby R, et al. Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci U S A. 2003;100:669-74 pubmed
    ..These opposing roles of MCIP have important implications for therapeutic strategies to regulate cardiac hypertrophy through modulation of calcineurin-MCIP activity. ..
  15. Perlingeiro R. Endoglin is required for hemangioblast and early hematopoietic development. Development. 2007;134:3041-8 pubmed
    ..Taken together, these findings point to a role for endoglin in both hemangioblast specification and hematopoietic commitment. ..
  16. Espenshade P, Cheng D, Goldstein J, Brown M. Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. J Biol Chem. 1999;274:22795-804 pubmed
    ..Espenshade, P. J., Slaughter, C. A., Jaen, J. C., Brown, M. S., and Goldstein, J. L. (1999), J. Biol. Chem., 274, 22805-22812), we develop an in vitro assay to characterize the activity of purified recombinant S1P. ..
  17. Rawson R, DeBose Boyd R, Goldstein J, Brown M. Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein. J Biol Chem. 1999;274:28549-56 pubmed
    ..These results provide formal proof that SCAP is essential for the cleavage of SREBPs at site 1...
  18. Ren F, Wang B, Yue T, Yun E, Ip Y, Jiang J. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A. 2010;107:21064-9 pubmed publisher
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS. ..
  19. Ye J, Rawson R, Komuro R, Chen X, Dav U, Prywes R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000;6:1355-64 pubmed
    ..ATF6 processing did not require SCAP, which is essential for SREBP processing. We conclude that S1P and S2P are required for the ER stress response as well as for lipid synthesis...
  20. Frey N, Barrientos T, Shelton J, Frank D, Rütten H, Gehring D, et al. Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nat Med. 2004;10:1336-43 pubmed
    ..These findings show important roles for calsarcins as modulators of calcineurin signaling and the transmission of a specific subset of stress signals leading to cardiac remodeling in vivo. ..
  21. Liu X, Li P, Widlak P, Zou H, Luo X, Garrard W, et al. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A. 1998;95:8461-6 pubmed
    ..DFF40 also triggered chromatin condensation when incubated with nuclei. These data suggest that DFF40 is sufficient to trigger both DNA fragmentation and chromatin condensation during apoptosis. ..
  22. Liu L, Eby M, Rathore N, Sinha S, Kumar A, Chaudhary P. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem. 2002;277:13745-51 pubmed
    ..Our results suggest that HHV8 vFLIP might contribute to the persistent NF-kappaB activation observed in PEL cells by associating with and stimulating the activity of the cellular IKK complex. ..
  23. Moon Y, Liang G, Xie X, Frank Kamenetsky M, Fitzgerald K, Koteliansky V, et al. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab. 2012;15:240-6 pubmed publisher
    ..Inhibition of SREBP activation has therapeutic potential for treatment of hypertriglyceridemia and fatty liver disease. ..
  24. Asaithamby A, Uematsu N, Chatterjee A, Story M, Burma S, Chen D. Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts. Radiat Res. 2008;169:437-46 pubmed publisher
    ..Collectively, these data demonstrate that the inability of cells to rejoin DSBs within clustered DNA lesions likely contributes to the greater biological effectiveness of HZE particles. ..
  25. Feramisco J, Radhakrishnan A, Ikeda Y, Reitz J, Brown M, Goldstein J. Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change. Proc Natl Acad Sci U S A. 2005;102:3242-7 pubmed publisher
    ..These data identify an important functional residue in SCAP, and they provide genetic evidence that the conformation of SCAP dictates the rate of cholesterol synthesis in animal cells...
  26. Xia D, Stull J, Kamm K. Myosin phosphatase targeting subunit 1 affects cell migration by regulating myosin phosphorylation and actin assembly. Exp Cell Res. 2005;304:506-17 pubmed
    ..Proper expression of MYPT1 or variant 2 is critical for RLC phosphorylation and actin assembly, thus maintaining normal cellular functions by simultaneously controlling cytoskeletal architecture and actomyosin activation. ..
  27. Kuriyama H, Liang G, Engelking L, Horton J, Goldstein J, Brown M. Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Cell Metab. 2005;1:41-51 pubmed
    ..Plasma VLDL triglycerides are dramatically reduced in L-Scap- mice, underscoring the benefits of synthesizing FAs in fat rather than liver. ..
  28. Shimomura I, Matsuda M, Hammer R, Bashmakov Y, Brown M, Goldstein J. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell. 2000;6:77-86 pubmed
    ..The combination of insulin resistance (inappropriate gluconeogenesis) and insulin sensitivity (elevated lipogenesis) establishes a vicious cycle that aggravates hyperinsulinemia and insulin resistance in lipodystrophic and ob/ob mice. ..
  29. Probst B, Liu L, Ramesh V, Li L, Sun H, Minna J, et al. Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-?-dependent manner. Cell Death Differ. 2010;17:1645-54 pubmed publisher
    ..Collectively, we provide mechanistic and applicable data to support translational studies in the use of a Smac mimetic/chemotherapy antineoplasm modality. ..
  30. Liao X, Butow R. RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell. 1993;72:61-71 pubmed
    ..Thus, RTG1 and RTG2 are pivotal genes in controlling interorganelle communication between mitochondria, peroxisomes, and the nucleus. ..
  31. Contreras C, Akbay E, Gallardo T, Haynie J, Sharma S, Tagao O, et al. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech. 2010;3:181-93 pubmed publisher
    ..These studies demonstrate that Lkb1 is a uniquely potent endometrial tumor suppressor, but also suggest that the clinical responses of some types of invasive cancers to mTOR inhibitors may be linked to Lkb1 status. ..
  32. An S, Cha S, Yoon J, Chang S, Ross E, Huang C. WNK1 promotes PIP? synthesis to coordinate growth factor and GPCR-Gq signaling. Curr Biol. 2011;21:1979-87 pubmed publisher
    ..These findings describe a new signaling pathway for Akt-activating growth factors, a mechanism for G protein-growth factor crosstalk, and a means to independently control PLC signaling and PIP(2) availability. ..
  33. Yue T, Tian A, Jiang J. The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell. 2012;22:255-67 pubmed publisher
    ..Overexpression of Sav or dimerized Ed cytoplasmic domain suppressed loss-of-Ed phenotypes. We propose that Ed may link cell-cell contact to Hpo signaling through binding and stabilizing Sav, thus modulating the Hpo kinase activity. ..
  34. Liu Z, Sekito T, Epstein C, Butow R. RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J. 2001;20:7209-19 pubmed
    ..These data, together with genome-wide transcription profiling, reveal pathways regulated by glutamate, and provide insight into the regulation of cellular responses to mitochondrial dysfunction. ..
  35. Wang L, Du F, Wang X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell. 2008;133:693-703 pubmed publisher
    ..These findings revealed that TNF-alpha is able to induce apoptosis via two distinct caspase-8 activation pathways that are differentially regulated by cIAP1/2 and c-FLIP. ..
  36. Xu B, Stippec S, Lenertz L, Lee B, Zhang W, Lee Y, et al. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem. 2004;279:7826-31 pubmed
    ..Finally, ERK5 activation by epidermal growth factor was attenuated by suppression of WNK1 expression using small interfering RNA. Taken together, these results place WNK1 in the ERK5 MAP kinase pathway upstream of MEKK2/3. ..
  37. Lee B, Min X, Heise C, Xu B, Chen S, Shu H, et al. WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Mol Cell. 2004;15:741-51 pubmed
    ..These findings provide a biochemical mechanism that could lead to the retention or insertion of proteins in the plasma membrane. Interruption of this regulatory pathway may disturb membrane events that regulate ion balance. ..
  38. Petersen S, Wang L, Yalcin Chin A, Li L, Peyton M, Minna J, et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell. 2007;12:445-56 pubmed
    ..In response to autocrine TNFalpha signaling, the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis. ..
  39. Sinton C. Orexin/hypocretin plays a role in the response to physiological disequilibrium. Sleep Med Rev. 2011;15:197-207 pubmed publisher
    ..Furthermore, the limit placed on the onset of sleep by orexin suggests that these adaptive processes then continue during sleep to become integrated into the development of a coping strategy for the longer term. ..
  40. Siede W, Friedberg A, Dianova I, Friedberg E. Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents. Genetics. 1994;138:271-81 pubmed
    ..We suggest that an intermediate of nucleotide excision repair, such as DNA strand breaks or single-stranded DNA tracts, is required to activate RAD9-dependent G1 and G1/S checkpoint controls. ..
  41. DeBose Boyd R, Brown M, Li W, Nohturfft A, Goldstein J, Espenshade P. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell. 1999;99:703-12 pubmed
    ..Transport-dependent proteolysis may be a common mechanism to regulate the processing of membrane proteins. ..
  42. Arguello A, Fischer S, Schonborn J, Markus R, Brekken R, Eisch A. Effect of chronic morphine on the dentate gyrus neurogenic microenvironment. Neuroscience. 2009;159:1003-10 pubmed publisher
    ..These data suggest that following chronic morphine exposure, factors within the neurogenic microenvironment are maintained or upregulated to compensate for decreased SGZ proliferation. ..
  43. Lee J, Ye J. Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. J Biol Chem. 2004;279:45257-65 pubmed
    ..The current study demonstrates that animal cells, in response to either hypotonic shock or ER stress, can bypass the cholesterol inhibition of SREBP processing, an effect that is attributable to the rapid turnover of Insig-1. ..
  44. Lee B, Chen W, Stippec S, Cobb M. Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway. J Biol Chem. 2007;282:17985-96 pubmed
    ..In addition, TGFbeta-induced target gene transcripts were increased in WNK1 small interfering RNA cells. These findings suggest WNK1 as a dual modulator of TGFbeta-Smad signaling pathways. ..
  45. Tu S, Bugde A, Luby Phelps K, Cobb M. WNK1 is required for mitosis and abscission. Proc Natl Acad Sci U S A. 2011;108:1385-90 pubmed publisher
    ..We conclude that decreased cell survival associated with loss of WNK1 is attributable to defects in chromosome segregation and abscission and is independent of the effector kinase OSR1. ..
  46. Hwang S, Nguyen A, Jo Y, Engelking L, Brugarolas J, DeBose Boyd R. Hypoxia-inducible factor 1? activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver. J Biol Chem. 2017;292:9382-9393 pubmed publisher
    ..These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia. ..
  47. Hua X, Nohturfft A, Goldstein J, Brown M. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell. 1996;87:415-26 pubmed
    ..SCAP appears to be a central regulator of cholesterol metabolism in animal cells...
  48. Schuppin G, Pons S, Hugl S, Aiello L, King G, White M, et al. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 1998;47:1074-85 pubmed
    ..It is conceivable that IRS-2 expression in beta-cells contributes to maintaining the islet beta-cell population, complementary to observations in the IRS-2 knockout mouse in which beta-cell mass is markedly reduced. ..
  49. Ferreira Junior J, Spirek M, Liu Z, Butow R. Interaction between Rtg2p and Mks1p in the regulation of the RTG pathway of Saccharomyces cerevisiae. Gene. 2005;354:2-8 pubmed
    ..Together, our data suggest that dynamic association between Mks1p and Rtg2p in high molecular weight complexes provides a means to regulate the RTG pathway. ..
  50. Jaumouillé V, Farkash Y, Jaqaman K, Das R, Lowell C, Grinstein S. Actin cytoskeleton reorganization by Syk regulates Fc? receptor responsiveness by increasing its lateral mobility and clustering. Dev Cell. 2014;29:534-546 pubmed publisher
  51. Yang T, Goldstein J, Brown M. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum. J Biol Chem. 2000;275:29881-6 pubmed
    ..These studies provide a potential mechanistic explanation for the ability of sterols to block SCAP.SREBP movement from the ER and thereby to control lipid synthesis in animal cells. ..
  52. Matsuda M, Korn B, Hammer R, Moon Y, Komuro R, Horton J, et al. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 2001;15:1206-16 pubmed
    ..These data provide in vivo evidence that SCAP and the SREBPs are required for hepatic lipid synthesis under basal and adaptive conditions. ..
  53. Espenshade P, Li W, Yabe D. Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER. Proc Natl Acad Sci U S A. 2002;99:11694-9 pubmed publisher
    ..These studies demonstrate feedback control of a biosynthetic pathway by the regulated binding of COPII proteins to an endoplasmic reticulum-to-Golgi transport protein...
  54. DiLeone R, Georgescu D, Nestler E. Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci. 2003;73:759-68 pubmed
    ..Regulation of LH intracellular signaling pathways in response to drugs of abuse supports a role for the LH neuropeptides in addiction. ..
  55. Dobrosotskaya I, Goldstein J, Brown M, Rawson R. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. J Biol Chem. 2003;278:35837-43 pubmed
    ..They indicate that insect cells can respond to sterols when proper regulatory proteins are expressed. ..
  56. Wu S, Huang J, Dong J, Pan D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell. 2003;114:445-56 pubmed
    ..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals. ..
  57. Sozio M, Mathis M, Young J, Walchli S, Pitcher L, Wrage P, et al. PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit. J Biol Chem. 2004;279:7760-9 pubmed
    ..This is the first reported demonstration that PTPH1 is a candidate PTPase capable of interacting with and dephosphorylating TCR zeta. ..
  58. Wang H, Liu Z, Huang C. Domains of WNK1 kinase in the regulation of ROMK1. Am J Physiol Renal Physiol. 2008;295:F438-45 pubmed publisher
    ..Thus, multiple intra- and/or intermolecular interactions of WNK1 domains are at play for regulation of ROMK1 by WNK1. ..
  59. Henke R, Meredith D, Borromeo M, Savage T, Johnson J. Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube. Dev Biol. 2009;328:529-40 pubmed publisher
    ..Thus, a complex interplay of E-box binding proteins spatially and temporally regulate Dll3 levels during neural tube development. ..
  60. Takahashi M, Koi M, Balaguer F, Boland C, Goel A. MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin, and a poly(ADP-ribose) polymerase inhibitor. J Biol Chem. 2011;286:12157-65 pubmed publisher
    ..These data lay the foundation for the development of effective prediction and treatments for cancers with MSH3 deficiency. ..
  61. Gao W, Shen Z, Shang L, Wang X. Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death. Cell Death Differ. 2011;18:1598-607 pubmed publisher
    ..These findings suggest that ULK1 and ULK2 may mediate part of tumor suppression activity in mammalian cells and contribute to the efficacy of genotoxic chemotherapeutic drugs. ..
  62. Radhakrishnan A, Sun L, Kwon H, Brown M, Goldstein J. Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Mol Cell. 2004;15:259-68 pubmed
    ..The current studies show that cells control their cholesterol content through receptor-ligand interactions and not through changes in the physical properties of the membrane. ..
  63. Kanayama A, Seth R, Sun L, Ea C, Hong M, Shaito A, et al. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004;15:535-48 pubmed
    ..These results indicate that polyubiquitin binding domains represent a new class of signaling domains that regulate protein kinase activity through a nonproteolytic mechanism. ..
  64. Xu B, Stippec S, Chu P, Lazrak A, Li X, Lee B, et al. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A. 2005;102:10315-20 pubmed
    ..This finding provides compelling evidence that this molecular mechanism contributes to the pathogenesis of hypertension in pseudohypoaldosteronism type II caused by WNK1 and, possibly, in other forms of hypertension...
  65. Gong Y, Lee J, Lee P, Goldstein J, Brown M, Ye J. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metab. 2006;3:15-24 pubmed
    ..When the new Insig-1 and cholesterol converge on Scap, Scap/SREBP binds to Insig-1, preventing ubiquitination. The Insig-1/Scap/SREBP complex accumulates in the ER, ready for liberation when the cell is again sterol deprived. ..
  66. Lee J, Song B, DeBose Boyd R, Ye J. Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. J Biol Chem. 2006;281:39308-15 pubmed
  67. Kim H, Jiang X, Du F, Wang X. PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Mol Cell. 2008;30:239-47 pubmed publisher
    ..These studies indicated that PHAPI, CAS, and Hsp70 play an important regulatory role during apoptosis. ..
  68. McMahon K, Zajicek H, Li W, Peyton M, Minna J, Hernandez V, et al. SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. EMBO J. 2009;28:1001-15 pubmed publisher
    ..We conclude that SRBC (sdr-related gene product that binds to c-kinase) and two other family members [PTRF (Pol I and transcription release factor) and SDPR] function as caveolin adapter molecules that regulate caveolae function. ..
  69. Dumka D, Puri P, Carayol N, Lumby C, Balachandran H, Schuster K, et al. Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma. 2009;50:2017-29 pubmed publisher
  70. Huang Y, He S, Li J, Seo Y, Osborne T, Cohen J, et al. A feed-forward loop amplifies nutritional regulation of PNPLA3. Proc Natl Acad Sci U S A. 2010;107:7892-7 pubmed publisher
  71. Kramer H. Neuralized: regulating notch by putting away delta. Dev Cell. 2001;1:725-6 pubmed
    ..Neuralized acts in a subset of Notch-dependent cell fate decisions including lateral inhibition in Drosophila neurogenesis. Three recent papers reveal that Neuralized acts as a ubiquitin ligase and triggers endocytosis of the ligand Delta. ..
  72. Willie J, Chemelli R, Sinton C, Tokita S, Williams S, Kisanuki Y, et al. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron. 2003;38:715-30 pubmed
  73. He G, Wang H, Huang S, Huang C. Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest. 2007;117:1078-87 pubmed
    ..Disease-causing WNK4 mutations enhanced interactions of WNK4 with ITSN and ROMK1, leading to increased endocytosis of ROMK1. These results provide a molecular mechanism for stimulation of endocytosis of ROMK1 by WNK kinases. ..
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