Experts and Doctors on immunohistochemistry in Houston, Texas, United States

Summary

Locale: Houston, Texas, United States
Topic: immunohistochemistry

Top Publications

  1. Hameed A, Truong L, Price V, Kruhenbuhl O, Tschopp J. Immunohistochemical localization of granzyme B antigen in cytotoxic cells in human tissues. Am J Pathol. 1991;138:1069-75 pubmed
  2. Bhat M, Philp A, Glover D, Bellen H. Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. Cell. 1996;87:1103-14 pubmed
    ..We propose that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase. ..
  3. Fueyo J, Alemany R, Gomez Manzano C, Fuller G, Khan A, Conrad C, et al. Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst. 2003;95:652-60 pubmed
    ..The antitumor activity of Delta-24-RGD suggests that it has the potential to be an effective agent in the treatment of gliomas. ..
  4. Slomovitz B, Broaddus R, Burke T, Sneige N, Soliman P, Wu W, et al. Her-2/neu overexpression and amplification in uterine papillary serous carcinoma. J Clin Oncol. 2004;22:3126-32 pubmed
    ..Overexpression of Her-2/neu was associated with a worse overall prognosis. The use of trastuzumab (Herceptin; Genentech, South San Francisco, CA) in women with UPSC should be further evaluated in a clinical trial setting. ..
  5. Kuo M, Wei Y, Yang X, Tatebe S, Liu J, Troncoso P, et al. Association of fragile site-associated (FSA) gene expression with epithelial differentiation and tumor development. Biochem Biophys Res Commun. 2006;340:887-93 pubmed
    ..Moreover, levels of FSA expression are downregulated in tumors of these tissue origins. These results suggest that FSA also plays important roles in regulating mammalian epithelial growth and differentiation and tumor development. ..
  6. Greenbaum M, Yan W, Wu M, Lin Y, Agno J, Sharma M, et al. TEX14 is essential for intercellular bridges and fertility in male mice. Proc Natl Acad Sci U S A. 2006;103:4982-7 pubmed
    ..Thus, TEX14 is required for intercellular bridges in vertebrate germ cells, and these studies provide evidence that the intercellular bridge is essential for spermatogenesis and fertility. ..
  7. Baruch A, Wang H, Staerkel G, Evans D, Hwang R, Krishnamurthy S. Immunocytochemical study of the expression of mesothelin in fine-needle aspiration biopsy specimens of pancreatic adenocarcinoma. Diagn Cytopathol. 2007;35:143-7 pubmed
    ..The presence of occasional mesothelin expression in benign tissue, its very focal expression in malignant tissue may limit the utility of mesothelin as a marker of pancreatic adenocarcinomas in fine-needle aspiration (FNA) specimens. ..
  8. Kwon K, Ro J, Singhal N, Killen D, Sienko A, Allen T, et al. MUC4 expression in non-small cell lung carcinomas: relationship to tumor histology and patient survival. Arch Pathol Lab Med. 2007;131:593-8 pubmed
    ..11). MUC4 expression is common in pulmonary adenocarcinomas and may indicate a more favorable prognosis in early-stage adenocarcinomas. ..
  9. Dhillon N, Aggarwal B, Newman R, Wolff R, Kunnumakkara A, Abbruzzese J, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res. 2008;14:4491-9 pubmed publisher
    ..Oral curcumin is well tolerated and, despite its limited absorption, has biological activity in some patients with pancreatic cancer. ..

More Information

Publications347 found, 100 shown here

  1. Feng W, Brown R, Trung C, Li W, Wang L, Khoury T, et al. Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappaB pathways in human gastric adenocarcinoma. Ann Clin Lab Sci. 2008;38:195-209 pubmed
  2. Gilcrease M, Woodward W, Nicolas M, Corley L, Fuller G, Esteva F, et al. Even low-level HER2 expression may be associated with worse outcome in node-positive breast cancer. Am J Surg Pathol. 2009;33:759-67 pubmed publisher
  3. Yin C, Lin K, Ketterling R, Knudson R, Medeiros L, Barron L, et al. Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes. Am J Clin Pathol. 2009;131:663-70 pubmed publisher
    ..We conclude that CLL/SLL with t(2;14) (p16;q32) and BCL11A/IgH rearrangement is characterized by atypical morphologic features and unmutated IgV(H) genes. ..
  4. Dash P, Orsi S, Zhang M, Grill R, Pati S, Zhao J, et al. Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats. PLoS ONE. 2010;5:e11383 pubmed publisher
    ..As clinically proven interventions that can be used to minimize the damage following TBI are not currently available, the findings from this report support the further testing of valproate as an acute therapeutic strategy. ..
  5. Stewart K, Zhou Z, Zweidler Mckay P, Kleinerman E. Delta-like ligand 4-Notch signaling regulates bone marrow-derived pericyte/vascular smooth muscle cell formation. Blood. 2011;117:719-26 pubmed publisher
    ..Tumor growth was also inhibited. These data demonstrate a specific role for DLL4 in the formation of BM-derived pericytes/vSMCs and indicate that DLL4 may be a novel therapeutic target for the inhibition of vasculogenesis. ..
  6. Boyette Davis J, Dougherty P. Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by minocycline. Exp Neurol. 2011;229:353-7 pubmed publisher
    ..This is the first study to show changes in IENF density in oxaliplatin treated animals, and confirm not only a relationship between IENF loss and hypersensitivity but also prevention of both with minocycline treatment. ..
  7. Katz T, Goldberg L, Marquez D, Kimyai Asadi A, Polder K, Landau J, et al. Nonablative fractional photothermolysis for facial actinic keratoses: 6-month follow-up with histologic evaluation. J Am Acad Dermatol. 2011;65:349-356 pubmed publisher
    ..FP decreases the number of clinical AKs; however, posttreatment biopsy specimens indicate the histologic persistence of AKs (epidermal tumors). FP is not an adequate single-treatment modality for AKs. ..
  8. King K, Baldridge M, Weksberg D, Chambers S, Lukov G, Wu S, et al. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood. 2011;118:1525-33 pubmed publisher
    ..The deleterious effects of excessive IFN signaling may explain how hematologic abnormalities arise in patients with inflammatory conditions. ..
  9. Weissferdt A, Moran C. Pax8 expression in thymic epithelial neoplasms: an immunohistochemical analysis. Am J Surg Pathol. 2011;35:1305-10 pubmed publisher
    ..As Pax8 expression has been demonstrated to be limited to organs the development of which depends on this transcription factor, the possibility that the organogenesis of the thymic gland also depends on this factor should be explored. ..
  10. Lee S, Ghosh S, Han H, Stone R, Bottsford Miller J, Shen D, et al. Metronomic activity of CD44-targeted hyaluronic acid-paclitaxel in ovarian carcinoma. Clin Cancer Res. 2012;18:4114-21 pubmed publisher
    ..This study showed that MET HA-TXL regimens have substantial antitumor activity in ovarian carcinoma, likely via a predominant antiangiogenic mechanism. ..
  11. Ordonez N. Immunohistochemical endothelial markers: a review. Adv Anat Pathol. 2012;19:281-95 pubmed publisher
    ..A selection of markers that have potential diagnostic utility or are of current interest among pathologists are reviewed and compared with some of the more traditional markers that have been employed in diagnostic pathology...
  12. Choi E, Lewis A, Takei H, Ro J. Leptomeningeal carcinomatosis as initial presentation in adenocarcinoma of lung with signet ring cell features: an autopsy case report. Int J Clin Exp Pathol. 2012;5:972-6 pubmed
    ..g., ALK immunostaining and/or ALK gene rearrangement). ..
  13. Hartmann E, Rudelius M, Burger J, Rosenwald A. CCL3 chemokine expression by chronic lymphocytic leukemia cells orchestrates the composition of the microenvironment in lymph node infiltrates. Leuk Lymphoma. 2016;57:563-71 pubmed publisher
    ..In conclusion, we demonstrate an association of CCL3 expression by CLL cells with increased numbers of CD3+ T cells and CD57+ cells in the lymph node microenvironment, which may promote CLL cell survival and proliferation. ..
  14. Karpen H, Bukowski J, Hughes T, Gratton J, Sessa W, Gailani M. The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J Biol Chem. 2001;276:19503-11 pubmed
    ..These data suggest that caveolin-1 may be integral for sequestering the Hh receptor complex in these caveolin-enriched microdomains, which act as a scaffold for the interactions with the Hh protein. ..
  15. Chen C, Behringer R. Cloning, structure, and expression of the mouse Ovca1 gene. Biochem Biophys Res Commun. 2001;286:1019-26 pubmed
    ..Based on gene homology, structure, and expression patterns, these findings indicate that mouse Ovca1 is the orthologue of human OVCA1/DPH2L1. This study will facilitate experiments to elucidate the in vivo role of Ovca1 in cancer. ..
  16. Deavers M, Malpica A, Ordonez N, Silva E. Ovarian steroid cell tumors: an immunohistochemical study including a comparison of calretinin with inhibin. Int J Gynecol Pathol. 2003;22:162-7 pubmed
    ..MART-1 (Ab3) immunostaining may be useful for cases in which melanoma is considered in the differential diagnosis. ..
  17. Resetkova E, Sahin A, Ayala A, Sneige N. Breast carcinoma with choriocarcinomatous features. Ann Diagn Pathol. 2004;8:74-9 pubmed
    ..Immunostaining for the beta subunit of human chorionic gonadotropin was localized mostly, but not entirely, to multinucleated syncytiotrophoblast-like giant cells within both tumors. ..
  18. Ribalta T, McCutcheon I, Aldape K, Bruner J, Fuller G. The mitosis-specific antibody anti-phosphohistone-H3 (PHH3) facilitates rapid reliable grading of meningiomas according to WHO 2000 criteria. Am J Surg Pathol. 2004;28:1532-6 pubmed
    ..PHH3 immunostaining facilitates the rapid reliable grading of meningiomas by focusing attention on the most mitotically active areas and by allowing easy and objective differentiation of MFs from apoptotic nuclei. ..
  19. Ramakrishnan V, Shoher A, Ehrlich M, Powell S, Lucci A. Atypical dermatofibrosarcoma protuberans in the breast. Breast J. 2005;11:217-8 pubmed
  20. Boerboom D, Paquet M, Hsieh M, Liu J, Jamin S, Behringer R, et al. Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Cancer Res. 2005;65:9206-15 pubmed
    ..5 months of age. Together, these studies show a causal link between misregulated Wnt/beta-catenin signaling and GCT development and provide a novel model system for the study of GCT biology...
  21. Vorburger S, Hetrakul N, Xia W, Wilson Heiner M, Mirza N, Pollock R, et al. Gene therapy with E2F-1 up-regulates the protein kinase PKR and inhibits growth of leiomyosarcoma in vivo. Mol Cancer Ther. 2005;4:1710-6 pubmed
    ..Taken together, these data suggest that E2F-1 gene therapy and PKR modulation might be a promising treatment strategy for these tumors that are highly resistant to conventional therapies. ..
  22. Nash J, Barrett T, Kies M, Ross M, Sneige N, Diwan A, et al. Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. J Cutan Pathol. 2007;34:49-54 pubmed
    ..In analogy to breast carcinoma, these findings suggest the applicability of trastuzumab for patients with metastatic adnexal carcinomas demonstrating Her-2/neu amplification...
  23. Takei H, Bhattacharjee M, Rivera A, Dancer Y, Powell S. New immunohistochemical markers in the evaluation of central nervous system tumors: a review of 7 selected adult and pediatric brain tumors. Arch Pathol Lab Med. 2007;131:234-41 pubmed
    ..The judicious use of a panel of selected immunostains is unquestionably helpful in diagnostically challenging cases. In addition, IHC is also of great help in predicting the prognosis for certain brain tumors. ..
  24. Cao M, Eshoa C, Schultz C, Black J, Zu Y, Chang C. Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature. Arch Pathol Lab Med. 2007;131:301-5 pubmed
    ..A thorough discussion of the differential diagnosis of histiocytic sarcoma and a review of primary central nervous system histiocytic sarcoma are also presented...
  25. Hara F, Samuel S, Liu J, Rosen D, Langley R, Naora H. A homeobox gene related to Drosophila distal-less promotes ovarian tumorigenicity by inducing expression of vascular endothelial growth factor and fibroblast growth factor-2. Am J Pathol. 2007;170:1594-606 pubmed
    ..This study reveals a novel role for a homeobox gene in ovarian tumorigenicity by its induction of a proangiogenic, growth-stimulatory molecular program. ..
  26. Wong K, Lu K, Malpica A, Bodurka D, Shvartsman H, Schmandt R, et al. Significantly greater expression of ER, PR, and ECAD in advanced-stage low-grade ovarian serous carcinoma as revealed by immunohistochemical analysis. Int J Gynecol Pathol. 2007;26:404-9 pubmed
    ..These differences may lead to the development of different therapeutic strategies for women with either the low-grade or the high-grade form of OSC...
  27. Li J, Wang H, May S, Song X, Fueyo J, Fuller G, et al. Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas. J Neurooncol. 2008;88:11-7 pubmed publisher
    ..The ability to inhibit JNK activation might confer increased sensitivity to therapeutic modalities targeting this pathway. ..
  28. Middleton L, Price K, Puig P, Heydon L, Tarco E, Sneige N, et al. Implementation of American Society of Clinical Oncology/College of American Pathologists HER2 Guideline Recommendations in a tertiary care facility increases HER2 immunohistochemistry and fluorescence in situ hybridization concordance and decreases t. Arch Pathol Lab Med. 2009;133:775-80 pubmed publisher
  29. Yoon S, Roh D, Seo H, Kang S, Moon J, Song S, et al. An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: involvement of the sigma-1 receptor. Neuropharmacology. 2010;59:460-7 pubmed publisher
    ..Moreover, this effect of DHEAS on NMDA receptor activity is mediated by the activation of spinal sigma-1 receptors and not through the inhibition of GABA(A) receptors. ..
  30. Lam F, Burns A, Smith C, Rumbaut R. Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1. Am J Physiol Heart Circ Physiol. 2011;300:H468-75 pubmed publisher
    ..These data support the notion that platelets enhance neutrophil transmigration across the inflamed endothelium both in vivo and in vitro, via a PSGL-1-dependent mechanism. ..
  31. Monzon F, Alvarez K, Peterson L, Truong L, Amato R, Hernandez McClain J, et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod Pathol. 2011;24:1470-9 pubmed publisher
    ..Further exploration of 8q gain, 14q loss, MYC, HIF1A and EPAS1 (HIF2?) as molecular markers of tumor behavior and prognosis could aid in personalizing medicine for patients with clear-cell renal cell carcinoma. ..
  32. Neal C, Xu J, Li P, Mori S, Yang J, Neal N, et al. Overexpression of 14-3-3? in cancer cells activates PI3K via binding the p85 regulatory subunit. Oncogene. 2012;31:897-906 pubmed publisher
    ..These findings revealed a novel mechanism by which 14-3-3? overexpression activates PI3K, a key node in the mitogenic signaling network known to promote malignancies in many cell types. ..
  33. Burns A, Phillips S, Sokoya E. Pannexin protein expression in the rat middle cerebral artery. J Vasc Res. 2012;49:101-10 pubmed publisher
    ..Pannexins are a recently discovered family of proteins that could potentially be involved in cell-to-cell communication. Herein, we sought to determine whether pannexins are expressed in rat middle cerebral artery (MCA)...
  34. Alexandrescu S, Brown R, Tandon N, Bhattacharjee M. Neuron precursor features of spindle cell oncocytoma of adenohypophysis. Ann Clin Lab Sci. 2012;42:123-9 pubmed
    ..p-Akt and p-mTOR were expressed suggesting mTORC2. Gli2 showed nuclear expression in the tumoral cells. These findings suggest that SCO has neuron-like precursor cells. Sonic hedgehog and mTOR pathways are activated. ..
  35. Hu J, Ho A, Yuan L, Hu B, Hua S, Hwang S, et al. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A. 2013;110:14520-7 pubmed publisher
  36. Mackay B, Ordonez N, Salter J, Pollock R. Myofibroblastoma of the axilla. Ultrastruct Pathol. 1995;19:265-8 pubmed
    ..A diagnosis of myofibroblastoma was favored, although the possibility of a low-grade sarcoma could not be excluded. There has not been any indication of recurrence over a 4-month period of follow-up...
  37. Vivian J, Gan L, Olson E, Klein W. A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation. Dev Biol. 1999;208:44-55 pubmed
  38. Witte D, Thomas A, Ali N, Carlson N, Younes M. Expression of the vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligand VEGF-C in human colorectal adenocarcinoma. Anticancer Res. 2002;22:1463-6 pubmed
    ..05), but not with lymph node metastasis or depth of tumor invasion. Our results suggest that VEGFs promote cancer growth not only by stimulating angiogenesis, but also by acting on receptors present on the cancer cells themselves. ..
  39. Izzo J, Papadimitrakopoulou V, Liu D, den Hollander P, Babenko I, Keck J, et al. Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer. J Natl Cancer Inst. 2003;95:198-205 pubmed
  40. Wang L, Hoque A, Luo R, Yuan J, Lu Z, Nishimoto A, et al. Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. Clin Cancer Res. 2003;9:3660-6 pubmed
    ..Our results indicate that ARHI expression is markedly down-regulated in DCIS, and a further decrease in ARHI expression is associated with progression of breast cancer. ..
  41. Rassidakis G, Georgakis G, Oyarzo M, Younes A, Medeiros L. Lack of c-kit (CD117) expression in CD30+ lymphomas and lymphomatoid papulosis. Mod Pathol. 2004;17:946-53 pubmed
  42. Vakar Lopez F, Cheng C, Kim J, Shi G, Troncoso P, Tu S, et al. Up-regulation of MDA-BF-1, a secreted isoform of ErbB3, in metastatic prostate cancer cells and activated osteoblasts in bone marrow. J Pathol. 2004;203:688-95 pubmed
    ..These observations indicate that MDA-BF-1 is up-regulated in metastatic PCa and raise the interesting possibility that MDA-BF-1 may play a role in the metastasis and progression of PCa, particularly in bone. ..
  43. Murali D, Yoshikawa S, Corrigan R, Plas D, Crair M, Oliver G, et al. Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development. 2005;132:913-23 pubmed
  44. Akiyama H, Kim J, Nakashima K, Balmes G, Iwai N, Deng J, et al. Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A. 2005;102:14665-70 pubmed
    ..Thus, our results strongly suggest that all osteo-chondroprogenitor cells, as well as progenitors in a variety of tissues, are derived from Sox9-expressing precursors during mouse embryogenesis. ..
  45. Colman H, Giannini C, Huang L, Gonzalez J, Hess K, Bruner J, et al. Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas. Am J Surg Pathol. 2006;30:657-64 pubmed
    ..These results also suggest that pHH3 staining may be a useful method in other neoplasms in which accurate determination of proliferation potential is relevant to tumor grading or clinical treatment decision-making. ..
  46. Izzo J, Wu T, Wu X, Ensor J, Luthra R, Pan J, et al. Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma. J Clin Oncol. 2007;25:698-707 pubmed
    ..CD1 genotyping with other biomarkers may help create a biomarker-based prognostic model for EAC and CD1 may also serve as a therapeutic target. ..
  47. Sharma P, Shen Y, Wen S, Yamada S, Jungbluth A, Gnjatic S, et al. CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma. Proc Natl Acad Sci U S A. 2007;104:3967-72 pubmed
    ..001) and overall survival (P = 0.018) than did patients with similar-staged UC and fewer intratumoral CD8 TILs. We conclude that the extent of intratumoral CD8 TILs is an important prognostic indicator in advanced UC. ..
  48. Tao Q, Fujimoto J, Men T, Ye X, Deng J, Lacroix L, et al. Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene. J Natl Cancer Inst. 2007;99:1668-82 pubmed
    ..001). Gprc5a functions as a tumor suppressor in mouse lung, and human GPRC5A may share this property. The Gprc5a-deficient mouse is a novel model to study lung carcinogenesis and chemoprevention. ..
  49. Cho Vega J, Medeiros L, Prieto V, Vega F. Leukemia cutis. Am J Clin Pathol. 2008;129:130-42 pubmed
    ..We review the literature and recent advances pertaining to LC, with special emphasis on the immunohistochemical assessment and possible mechanisms involved in skin tropism by leukemic cells...
  50. Ofek G, Revell C, Hu J, Allison D, Grande Allen K, Athanasiou K. Matrix development in self-assembly of articular cartilage. PLoS ONE. 2008;3:e2795 pubmed publisher
    ..In terms of tissue engineering, it is suggested that exogenous stimulation may be necessary after 4 wks to further augment the functionality of developing constructs. ..
  51. Doherty S, Barrett T, Joseph A. Brooke-Spiegler syndrome: report of a case of multiple cylindromas and trichoepitheliomas. Dermatol Online J. 2008;14:8 pubmed
    ..Treatment of these patients can involve surgical excision, laser therapy, or topical applications of aspirin derivatives. ..
  52. Villares G, Zigler M, Wang H, Melnikova V, Wu H, Friedman R, et al. Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA. Cancer Res. 2008;68:9078-86 pubmed publisher
    ..We propose that siRNA incorporated into DOPC nanoparticles could be delivered systemically and used as a new modality for melanoma treatment. ..
  53. Vaid R, Cohen B. Primary cutaneous CD30 positive anaplastic large cell lymphoma in an adolescent. Pediatr Dermatol. 2009;26:721-4 pubmed publisher
    ..Very few cases of primary cutaneous CD30-positive anaplastic large cell lymphoma in the pediatric population have been reported, and our case represents one of the first pediatric patients with local lymph node involvement. ..
  54. Tseng H, Grande Allen K. Elastic fibers in the aortic valve spongiosa: a fresh perspective on its structure and role in overall tissue function. Acta Biomater. 2011;7:2101-8 pubmed publisher
    ..In conclusion, elastic fibers in the spongiosa connect the two outer layers and vary regionally in structure, while possibly playing a role in responding to regionally specific loading patterns. ..
  55. Barone I, Brusco L, Gu G, Selever J, Beyer A, Covington K, et al. Loss of Rho GDI? and resistance to tamoxifen via effects on estrogen receptor ?. J Natl Cancer Inst. 2011;103:538-52 pubmed publisher
    ..Loss of Rho GDI? enhances metastasis and resistance to tamoxifen via effects on both ER? and MTA2 in models of ER?-positive breast cancer and in tumors of tamoxifen-treated patients. ..
  56. Chen M, Felix K, Wang J. Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol. 2011;187:5684-92 pubmed publisher
    ..Bax- and Bak-dependent cell death mechanisms help to maintain DC homeostasis and contribute to the regulation of T cell activation and the suppression of autoimmunity. ..
  57. Yosef N, Ubogu E. GDNF restores human blood-nerve barrier function via RET tyrosine kinase-mediated cytoskeletal reorganization. Microvasc Res. 2012;83:298-310 pubmed publisher
    ..These observations provide insights into the regulation of human BNB function during recovery from peripheral nerve injury. ..
  58. Conrad C, Gregorio J, Wang Y, Ito T, Meller S, Hanabuchi S, et al. Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells. Cancer Res. 2012;72:5240-9 pubmed publisher
    ..These findings suggest an essential role for pDCs and ICOS-L in immunosuppression mediated by ICOS(+) Foxp3(+) Treg cells, leading to tumor progression in ovarian cancer. ..
  59. Ordonez N. Value of PAX2 immunostaining in tumor diagnosis: a review and update. Adv Anat Pathol. 2012;19:401-9 pubmed publisher
    ..Because of its restricted expression, PAX2 has proved to be a useful immunohistochemical marker with a wide range of diagnostic applications in surgical pathology, some of which will be briefly reviewed. ..
  60. Burra S, Wang Y, Brock A, Galko M. Using Drosophila larvae to study epidermal wound closure and inflammation. Methods Mol Biol. 2013;1037:449-61 pubmed publisher
    ..Finally, useful transgenic lines for live genetic screening of genes required for wound closure or inflammation are described. ..
  61. Sellheyer K, Bickenbach J, Rothnagel J, Bundman D, Longley M, Krieg T, et al. Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice. Proc Natl Acad Sci U S A. 1993;90:5237-41 pubmed
  62. Engelhardt J, Le W, Siklos L, Obal I, Boda K, Appel S. Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain. Arch Neurol. 2000;57:681-6 pubmed
    ..Data document that IgG from patients with AD can target a stereotaxically induced immune/inflammatory injury to cholinergic neurons in the rat basal forebrain in vivo. ..
  63. Soria J, Moon C, Wang L, Hittelman W, Jang S, Sun S, et al. Effects of N-(4-hydroxyphenyl)retinamide on hTERT expression in the bronchial epithelium of cigarette smokers. J Natl Cancer Inst. 2001;93:1257-63 pubmed
    ..hTERT expression is a promising potential biomarker for risk assessment and for the evaluation of the efficacy of chemopreventive agents in lung carcinogenesis. ..
  64. Li W, Trexler E, Massey S. Glutamate receptors at rod bipolar ribbon synapses in the rabbit retina. J Comp Neurol. 2002;448:230-48 pubmed
    ..Finally, the differential expression of glutamate receptors by S1 and S2 may partly explain the need for two wide-field GABA amacrine cells with the same feedback connections to rod bipolar terminals. ..
  65. Lee O, Frese K, James J, Chadda D, Chen Z, Javier R, et al. Discs-Large and Strabismus are functionally linked to plasma membrane formation. Nat Cell Biol. 2003;5:987-93 pubmed
    ..This effect was dependent on the interaction between Stbm and SAP97. These findings suggest that the Dlg-Stbm complex recruits membrane-associated proteins and lipids from internal membranes to sites of new plasma membrane formation. ..
  66. Han Z, Saam J, Adams H, Mango S, Schumacher J. The C. elegans Tousled-like kinase (TLK-1) has an essential role in transcription. Curr Biol. 2003;13:1921-9 pubmed
    ..In addition, our results confirm that the link between RNAPII phosphorylation and histone H3 methylation previously observed in budding yeast is functionally conserved in metazoans. ..
  67. Ismail P, DeMayo F, Amato P, Lydon J. Progesterone induction of calcitonin expression in the murine mammary gland. J Endocrinol. 2004;180:287-95 pubmed
  68. Zhang H, Kuang S, Liao L, Zhou S, Xu J. Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mamm. Cancer Res. 2004;64:7169-77 pubmed
    ..These results suggest that AIB3 may be a tumor suppressor that is required for the inhibition of cell proliferation by PPARgamma and RXR. ..
  69. Bahrami A, Ro J, Ayala A. An overview of testicular germ cell tumors. Arch Pathol Lab Med. 2007;131:1267-80 pubmed
    ..Teratomas in children regardless of maturity and dermoid cysts in adults are benign; in contrast, teratomas in adults have a malignant behavior. With appropriate therapy, the majority of testicular GCTs are curable. ..
  70. Seo H, Liu D, Bekele B, Kim M, Pisters K, Lippman S, et al. Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer. Cancer Res. 2008;68:6065-73 pubmed publisher
    ..These are the first reported results illustrating the potential of CREB as a molecular target for the prevention and treatment of NSCLC, especially in never smokers. ..
  71. Cabioglu N, Sahin A, Morandi P, Meric Bernstam F, Islam R, Lin H, et al. Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications. Ann Oncol. 2009;20:1013-9 pubmed publisher
    ..This finding might have important clinical implications since patients with metastatic bone disease may achieve the highest benefit from a CXCR4-targeted therapy. ..
  72. Feng S, Agoulnik I, Truong A, Li Z, Creighton C, Kaftanovskaya E, et al. Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis. Endocr Relat Cancer. 2010;17:1021-33 pubmed publisher
    ..Thus, the suppression of RLN/RXFP1 may have potential therapeutic benefits in prostate cancer. ..
  73. Zhang H, Nei H, Dougherty P. A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-alpha. J Neurosci. 2010;30:12844-55 pubmed publisher
    ..These results suggest a novel TNF?-TNFR1-p38 pathway in spinal GABAergic neurons that may contribute to the development of neuropathic and inflammatory pain by TNF?. ..
  74. Hoshi H, Tian L, Massey S, Mills S. Two distinct types of ON directionally selective ganglion cells in the rabbit retina. J Comp Neurol. 2011;519:2509-21 pubmed publisher
    ..2002). If there is an ON DS ganglion cell that does not stratify in the starburst band, this suggests that its GABA-dependent directional signals may be generated by a mechanism independent of starburst amacrine cells. ..
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    ..During embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells. These results suggest that Ten-m and Filamin in epidermal cells might together influence growth cone progression. ..
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    ..In conclusion, this paper describes the establishment of an animal model that shows sex differences in hyperoxic lung injury in a temporal manner and thus has important implications for lung diseases mediated by hyperoxia in humans. ..
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    ..These findings demonstrate that in neuroblastoma, the MYCN oncogene directly activates genes required for DNA replication, and this may contribute to neoplastic transformation of these MYCN-amplified tumors. ..
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    ..This article shows that macrophages are central to this and bolsters the likelihood of L. casei being the cause of KD. ..
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    ..7% (P = 0.0039), respectively. No association of Ki-67 SI with OS was observed. Higher Ki-67 SI was significantly associated with a greater risk of DM and DSS in locally advanced prostate cancer after definitive EBRT or AD + EBRT. ..
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    ..Transcriptional regulation by anti-HER2 antibody through PI3K-AKT pathway may potentiate the growth inhibitory activity of docetaxel by affecting cell cycle progression. ..
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    ..We conclude that the prolymphocytoid features of T-PLL cells can be difficult to detect in routinely stained sections of extramedullary biopsy specimens. TCL-1 expression can aid in diagnosis at extramedullary sites...
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    ..Therefore, additional studies in a larger series with adequate follow-up are necessary to elucidate the biologic significance of cystatin M expression in breast cancer metastasis. ..
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    ..Collectively, our data provide first clinical and casual evidence and potential mechanism that the alteration of KLF4 expression plays a critical role in gastric cancer development and progression. ..
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