Genomes and Genes
Experts and Doctors on homeostasis in Dallas, Texas, United States
Locale: Dallas, Texas, United States
Publications131 found, 100 shown here
- Chen Z, Medina F, Liu M, THOMAS C, Sprang S, Sternweis P. Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J Biol Chem. 2010;285:21070-81 pubmed publisher..PH bound to both forms of RhoA can be isolated by size-exclusion chromatography. This novel interaction between activated RhoA and PH could play a key role in regulation of RhoGEF activity in vivo. ..
- Stallings N, Puttaparthi K, Dowling K, Luther C, Burns D, Davis K, et al. TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis. PLoS ONE. 2013;8:e71793 pubmed publisher..These results indicate that levels of TDP-43 regulate body fat composition and glucose homeostasis in vivo. ..
- Zhou X, Luan X, Chen Z, Francis M, Gopinathan G, Li W, et al. MicroRNA-138 Inhibits Periodontal Progenitor Differentiation under Inflammatory Conditions. J Dent Res. 2016;95:230-7 pubmed publisher..Our data establish miR-138 inhibitor as a potential therapeutic agent for the prevention of the bone loss associated with advanced periodontal disease. ..
- Helms A, Abney A, Ben Arie N, Zoghbi H, Johnson J. Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development. 2000;127:1185-96 pubmed..In addition, we demonstrate a role for autoregulation in controlling the activity of the Math1 enhancer, through an essential E-box consensus binding site. ..
- Muthukumar A, Wozniakowski A, Gauduin M, Paiardini M, McClure H, Johnson R, et al. Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression. Blood. 2004;103:973-9 pubmed..The utility of IL-7 as a potential immunotherapeutic agent to improve HIV/SIV-related T-cell depletion may therefore depend on controlling the pathogenic effects of viral replication prior to the administration of IL-7. ..
- Repa J, Buhman K, Farese R, Dietschy J, Turley S. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Hepatology. 2004;40:1088-97 pubmed..Loss of ACAT2 activity may result in unesterified cholesterol being absorbed via an ABCA1-mediated basolateral efflux pathway...
- Padrick S, Cheng H, Ismail A, Panchal S, Doolittle L, Kim S, et al. Hierarchical regulation of WASP/WAVE proteins. Mol Cell. 2008;32:426-38 pubmed publisher..Allostery and dimerization act in hierarchical fashion, enabling WASP/WAVE proteins to integrate different classes of inputs to produce a wide range of cellular actin responses...
- Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan D, Mostoslavsky R, et al. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 2010;12:78-87 pubmed publisher..In summary, our results provide direct genetic evidence that SIRT1 in POMC neurons is required for normal autonomic adaptations against diet-induced obesity. ..
- Turley S, Valasek M, Repa J, Dietschy J. Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. Am J Physiol Gastrointest Liver Physiol. 2010;299:G1012-22 pubmed publisher..This resulted from a combination of compensatory mechanisms including diminished NPC1L1-mediated cholesterol uptake, increased cholesterol efflux via ABCG5/8, and possibly rapid cell turnover...
- He C, Bassik M, Moresi V, Sun K, Wei Y, Zou Z, et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012;481:511-5 pubmed publisher..Thus, exercise induces autophagy, BCL2 is a crucial regulator of exercise- (and starvation)-induced autophagy in vivo, and autophagy induction may contribute to the beneficial metabolic effects of exercise. ..
- Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, et al. Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2016;531:323-8 pubmed publisher..Our approach demonstrates a novel treatment strategy for cataracts and provides a new paradigm for tissue regeneration using endogenous stem cells. ..
- Amanzadeh J, Reilly R. Hypophosphatemia: an evidence-based approach to its clinical consequences and management. Nat Clin Pract Nephrol. 2006;2:136-48 pubmed..By contrast, patients with severe hypophosphatemia should be treated. Intravenous repletion may be considered, especially for patients who have clinical sequelae of hypophosphatemia...
- Carrer M, Liu N, Grueter C, Williams A, Frisard M, Hulver M, et al. Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A. 2012;109:15330-5 pubmed..Thus, these miRNAs provide potential targets for pharmacologic intervention in obesity and metabolic syndrome. ..
- Vaishnava S, Yamamoto M, Severson K, Ruhn K, Yu X, Koren O, et al. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science. 2011;334:255-8 pubmed publisher..Together, our findings reveal that RegIII? is a fundamental immune mechanism that promotes host-bacterial mutualism by regulating the spatial relationships between microbiota and host. ..
- Signer R, Magee J, Salic A, Morrison S. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014;509:49-54 pubmed publisher..Pten deficiency thus depletes HSCs and promotes leukaemia partly by increasing protein synthesis. Either increased or decreased protein synthesis impairs HSC function. ..
- Choi E, Zhang X, Xing C, Yu H. Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis. Cell. 2016;166:567-581 pubmed publisher..Our findings establish a major IR regulatory mechanism and link guardians of chromosome stability to nutrient metabolism. ..
- Yan L, Christians E, Liu L, Xiao X, Sohal R, Benjamin I. Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J. 2002;21:5164-72 pubmed
- Robertson D, Petroll W, Jester J, Cavanagh H. The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and pseudomonas binding to corneal cells: an overview. Eye Contact Lens. 2007;33:394-8; discussion 399-400 pubmed..Significantly, hyper-oxygen-transmissible lenses in any wearing mode with non-preserved care solutions appear to offer the safest potential clinical choice for contact lens wear. ..
- Wang X, Wang S, Lu Y, Gibson M, Liu Y, Yuan B, et al. FAM20C plays an essential role in the formation of murine teeth. J Biol Chem. 2012;287:35934-42 pubmed publisher..Collectively, these data indicate that FAM20C is essential to the differentiation and mineralization of dental tissues through the regulation of molecules critical to the differentiation of tooth-formative cells. ..
- ..Thus, the bone-kidney endocrine axis mediated by FGF23 and Klotho has emerged as a novel target of therapeutic interventions in CKD. ..
- Mosialou I, Shikhel S, Liu J, Maurizi A, Luo N, He Z, et al. MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature. 2017;543:385-390 pubmed publisher..These results identify LCN2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R-dependent manner, and show that the control of appetite is an endocrine function of bone. ..
- Vaishnava S, Behrendt C, Ismail A, Eckmann L, Hooper L. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A. 2008;105:20858-63 pubmed publisher..Our findings establish that gut epithelia actively sense enteric bacteria and play an essential role in maintaining host-microbial homeostasis at the mucosal interface...
- Broberg C, Zhang L, Gonzalez H, Laskowski Arce M, Orth K. A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity. Science. 2010;329:1660-2 pubmed publisher..Thus, bacterial pathogens can disrupt adaptor protein-binding sites required for proper membrane and cytoskeleton dynamics by altering the homeostasis of membrane-bound inositol-signaling molecules...
- Xu Y, Berglund E, Sohn J, Holland W, Chuang J, Fukuda M, et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010;13:1457-9 pubmed publisher..Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver. ..
- Park M, Li Q, Shcheynikov N, Zeng W, Muallem S. NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell. 2004;16:331-41 pubmed..These findings may reveal a previously unrecognized role for NaBC1 in borate homeostasis and open the way to better understanding of the many presumed physiological roles of borate in animals. ..
- Franken P, Dudley C, Estill S, Barakat M, Thomason R, O Hara B, et al. NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions. Proc Natl Acad Sci U S A. 2006;103:7118-23 pubmed..In contrast, the rebound in NREMS time after SD was compromised only in npas2-/- males. We conclude that NPAS2 plays a role in sleep homeostasis, most likely at the level of the thalamus and cortex, where NPAS2 is abundantly expressed. ..
- Vaishnava S, Hooper L. Alkaline phosphatase: keeping the peace at the gut epithelial surface. Cell Host Microbe. 2007;2:365-7 pubmed
- Yang C. An enzyme-centric approach for modelling non-linear biological complexity. BMC Syst Biol. 2008;2:70 pubmed publisher..The simulations presented in this paper reveal how a living system maintains homeostasis and its robustness to continue functioning while facing environmental stresses or genetic mutations. ..
- Zhao Y, Abreu E, Kim J, Stadler G, Eskiocak U, Terns M, et al. Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Mol Cell. 2011;42:297-307 pubmed publisher..Overexpressed telomerase is also less processive than the endogenously expressed telomerase. These findings reveal two major distinct extension modes adopted by telomerase in vivo. ..
- Baum M, Twombley K, Gattineni J, Joseph C, Wang L, Zhang Q, et al. Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice. Am J Physiol Renal Physiol. 2012;303:F1495-502 pubmed publisher..In conclusion, NHE3 is the predominant Na(+)/H(+) exchanger in adult mice. NHE8 may play a compensatory role in renal acidification and blood pressure regulation in NHE3(-/-) mice. ..
- Zhang Y, Lee K, Kinch L, Clark L, Grishin N, Rosenbaum D, et al. Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS. J Biol Chem. 2016;291:12888-96 pubmed publisher..Point mutations that disrupt the Loop1-Loop7 interaction prevented secretion of the Loop1-Loop7 fusion protein. These data provide direct documentation of intramolecular Loop1-Loop7 binding, a central event in cholesterol homeostasis. ..
- Muthukumar A, Zhou D, Paiardini M, Barry A, Cole K, McClure H, et al. Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys. Blood. 2005;106:3839-45 pubmed
- Grueter C, van Rooij E, Johnson B, DeLeon S, Sutherland L, Qi X, et al. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell. 2012;149:671-83 pubmed publisher..These findings reveal a role of the heart in systemic metabolic control and point to MED13 and miR-208a as potential therapeutic targets for metabolic disorders. ..
- Janowski B. The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP. Proc Natl Acad Sci U S A. 2002;99:12675-80 pubmed..Taken together, these data suggest that INSIG-1 plays a critical role in regulating cholesterol concentrations in the cell. ..
- Park M, Li Q, Shcheynikov N, Muallem S, Zeng W. Borate transport and cell growth and proliferation. Not only in plants. Cell Cycle. 2005;4:24-6 pubmed
- Gong Y, Lee J, Brown M, Goldstein J, Ye J. Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Natl Acad Sci U S A. 2006;103:6154-9 pubmed..These studies identify a single amino acid residue that is crucial for the function of Insig proteins in regulating cholesterol homeostasis in mammalian cells. ..
- Dann C, Wakeman C, Sieling C, Baker S, Irnov I, Winkler W. Structure and mechanism of a metal-sensing regulatory RNA. Cell. 2007;130:878-92 pubmed..Given the distribution of this RNA element, it may constitute a common mode for bacterial metal ion regulation, and its discovery suggests the possibility of additional RNA-based metal sensors in modern and primordial organisms. ..
- Motamed M, Zhang Y, Wang M, Seemann J, Kwon H, Goldstein J, et al. Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis. J Biol Chem. 2011;286:18002-12 pubmed publisher..These results indicate that luminal Loop 1 of Scap controls the conformation of cytosolic Loop 6, thereby determining whether cells produce cholesterol. ..
- Deka R, Brautigam C, Liu W, Tomchick D, Norgard M. The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis. J Biol Chem. 2013;288:11106-21 pubmed publisher..TP0796 is the first structurally and biochemically characterized FAD pyrophosphate enzyme in bacteria. This new paradigm for a bacterial flavin utilization pathway may prove to be useful for future inhibitor design. ..
- Tuckerman J, Gonzalez G, Sousa E, Wan X, Saito J, Alam M, et al. An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control. Biochemistry. 2009;48:9764-74 pubmed publisher..Finally, we find that DosP and DosC associate into a functional complex. We conclude that the dosCP operon encodes two oxygen sensors that cooperate in the controlled production and removal of c-di-GMP. ..
- Unger R, Clark G, Scherer P, Orci L. Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim Biophys Acta. 2010;1801:209-14 pubmed publisher..Fatty acid derivatives can interfere with the function of the cell and ultimately lead to its demise through lipoapoptosis, the consequences of which are gradual organ failure. ..
- Donato J, FrazÃ£o R, Elias C. The PI3K signaling pathway mediates the biological effects of leptin. Arq Bras Endocrinol Metabol. 2010;54:591-602 pubmed..In particular, we focus on the importance of the PI3K signaling pathway as a mediator of the effects of leptin on hypothalamic neurons. ..
- Rossi J, Balthasar N, Olson D, Scott M, Berglund E, Lee C, et al. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab. 2011;13:195-204 pubmed publisher..Our results also provide further evidence of the dissociation in pathways mediating the effects of melanocortins on energy balance and glucose homeostasis. ..
- Cheng C, Kuro O M, Razzaque M. Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system. Adv Chronic Kidney Dis. 2011;18:91-7 pubmed publisher..This article will briefly summarize how delicate interactions of the FGF23-klotho system can regulate systemic phosphate homeostasis. ..
- Kir S, Kliewer S, Mangelsdorf D. Roles of FGF19 in liver metabolism. Cold Spring Harb Symp Quant Biol. 2011;76:139-44 pubmed publisher..The beneficial effects of FGF19 on liver metabolism raise the question of whether FGF19 and its variants can be used as therapeutic agents in the treatment of diabetes. ..
- Zechner J, Mirshahi U, Satapati S, Berglund E, Rossi J, Scott M, et al. Weight-independent effects of roux-en-Y gastric bypass on glucose homeostasis via melanocortin-4 receptors in mice and humans. Gastroenterology. 2013;144:580-590.e7 pubmed publisher..MC4Rs in autonomic neurons mediate beneficial effects of RYGB, including weight-independent improved glucose homeostasis, in mice and humans. ..
- Liu J, Zhu Y, Hill C, Armstrong K, Tarumi T, Hodics T, et al. Cerebral autoregulation of blood velocity and volumetric flow during steady-state changes in arterial pressure. Hypertension. 2013;62:973-9 pubmed publisher..However, it is likely to be underestimated when compared with the measurements of CBF and CVR in ICA. The inverse relationship between changes in ICA diameter and MAP suggests that large cerebral arteries are involved in CA. ..
- Beuckmann C, Yanagisawa M. Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J Mol Med (Berl). 2002;80:329-42 pubmed..A connection between sleep/wake regulation and energy homeostasis is hypothesized with orexin neuropeptides as a molecular link. ..
- Cui Y, Huang L, Elefteriou F, Yang G, Shelton J, Giles J, et al. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol. 2004;24:258-69 pubmed..These data thus suggest that loss of STAT3 in the hypothalamus caused by RIP-Cre action likely interferes with normal body weight homeostasis and glucose metabolism. ..
- Yang C, Yu L, Li W, Xu F, Cohen J, Hobbs H. Disruption of cholesterol homeostasis by plant sterols. J Clin Invest. 2004;114:813-22 pubmed..Stigmasterol also activated the liver X receptor in a cell-based reporter assay. These data indicate that selected dietary plant sterols disrupt cholesterol homeostasis by affecting two critical regulatory pathways of lipid metabolism...
- Hill J, Xu Y, Preitner F, Fukuda M, Cho Y, Luo J, et al. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009;150:4874-82 pubmed publisher..These studies show that activity of the PI3K pathway in POMC neurons is involved in not only normal energy regulation but also glucose homeostasis. ..
- Zhang Y, Breevoort S, Angdisen J, Fu M, Schmidt D, Holmstrom S, et al. Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest. 2012;122:1688-99 pubmed publisher..In sum, these observations suggest that therapeutic strategies that bypass the liver or limit the activation of hepatic LXRs should still be beneficial for the treatment of cardiovascular disease. ..
- Rangiani A, Cao Z, Liu Y, Voisey Rodgers A, Jiang Y, Qin C, et al. Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation. Int J Oral Sci. 2012;4:189-95 pubmed publisher..Based on the above findings, we conclude that DMP1 has a protective role for odontoblasts and ameloblasts in a pro-apoptotic environment (a high Pi level). ..
- Robertson D, Ladage P, Yamamoto N, Jester J, Petroll W, Cavanagh H. Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice. Eye Contact Lens. 2006;32:3-7 pubmed..Additional experiments to delineate the role of Bcl-2 and Bax during development and in the adult cornea are necessary. ..
- Luo X, Kraus W. On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes Dev. 2012;26:417-32 pubmed publisher..The development of PARP inhibitors is being pursued as a therapeutic approach to these conditions. In this review, we highlight the newest findings about PARP-1's role in stress responses in the context of the historical data. ..
- ..This chapter overviews function of Klotho family proteins as obligate coreceptors for endocrine FGFs and discusses potential link between Klothos and age-related diseases. ..
- Zhang J. Suppression of phosphoenolpyruvate carboxykinase gene expression by reduced endogenous glutathione level. Biochim Biophys Acta. 2007;1772:1175-81 pubmed
- Schmidt D, Mangelsdorf D. Nuclear receptors of the enteric tract: guarding the frontier. Nutr Rev. 2008;66:S88-97 pubmed publisher..The major homeostatic functions of the enteric nuclear receptor network are the topic of this review. ..
- Engelking L, McFarlane M, Li C, Liang G. Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes. J Lipid Res. 2012;53:1359-68 pubmed publisher..These studies reveal a hitherto undescribed homeostatic network in enterocytes triggered by blockade of cholesterol absorption...
- Mammen P, Kanatous S, Yuhanna I, Shaul P, Garry M, Balaban R, et al. Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice. Am J Physiol Heart Circ Physiol. 2003;285:H2132-41 pubmed..These new data establish that myoglobin is an important cytoplasmic cardiac hemoprotein that functions in regulating NO homeostasis within cardiomyocytes. ..
- Bingham N, Anderson K, Reuter A, Stallings N, Parker K. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology. 2008;149:2138-48 pubmed publisher..These data define nonredundant roles of the Lepr in VMH neurons in energy homeostasis and provide a model system for studying other actions of leptin in the VMH. ..
- Lee Y, Schmidt D, Cummins C, Choi M, Peng L, Zhang Y, et al. Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Mol Endocrinol. 2008;22:1345-56 pubmed publisher..Taken together, these data reveal a broad role for LRH-1 in regulating bile acid homeostasis but demonstrate that LRH-1 is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors. ..
- Lund E, Guileyardo J, Russell D. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A. 1999;96:7238-43 pubmed..We conclude that the cloned cDNAs encode cholesterol 24-hydroxylases that synthesize oxysterols in neurons of the brain and that secretion of 24S-hydroxycholesterol from this tissue in the mouse is developmentally regulated. ..
- Repa J, Turley S, Lobaccaro J, Medina J, Li L, Lustig K, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 2000;289:1524-9 pubmed..Thus, these RXR heterodimers serve as key regulators of cholesterol homeostasis by governing reverse cholesterol transport from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption in intestine...
- Sahin B, Kansy J, Nairn A, Spychala J, Ealick S, Fienberg A, et al. Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation. Eur J Biochem. 2004;271:3547-55 pubmed..Further analysis revealed, however, that this PKC-dependent phosphorylation occurred at one or more serine residues associated with the N-terminal affinity tag used for protein purification. ..
- Drewes P, Yanagisawa H, Starcher B, Hornstra I, Csiszar K, Marinis S, et al. Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina. Am J Pathol. 2007;170:578-89 pubmed
- Carlson D, Maass D, White J, Sikes P, Horton J. Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury. J Appl Physiol (1985). 2007;103:323-30 pubmed..The present data suggest that signaling through myocardial caspases plays a pivotal role in burn-related myocyte sodium dyshomeostasis and myocyte inflammation, perhaps contributing to burn-related contractile dysfunction. ..
- Ramadori G, Gautron L, Fujikawa T, Vianna C, Elmquist J, Coppari R. Central administration of resveratrol improves diet-induced diabetes. Endocrinology. 2009;150:5326-33 pubmed publisher..Collectively, our results unveiled a previously unrecognized key role for the CNS in mediating the antidiabetic actions of resveratrol. ..
- Liu S, Premont R, Rockey D. G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis. J Biol Chem. 2012;287:12309-20 pubmed publisher..Re-expression of GIT1 after liver injury rescued the endothelial phenotype. These data emphasize the role of GPCR signaling partners in eNOS function and have fundamental implications for vascular disorders involving dysregulated eNOS. ..
- Yang T, Espenshade P, Wright M, Yabe D, Gong Y, Aebersold R, et al. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell. 2002;110:489-500 pubmed..Mutant SCAP(Y298C) fails to bind INSIG-1 and is resistant to sterol-mediated inhibition of ER exit. By facilitating sterol-dependent ER retention of SCAP, INSIG-1 plays a central role in cholesterol homeostasis. ..
- Wilson T, Zhang R, Levine B, Crandall C. Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin. Am J Physiol Heart Circ Physiol. 2005;289:H385-91 pubmed..Conversely, these data suggest that nonglabrous skin has diminished dynamic autoregulatory capabilities. ..
- Shang J, Gao N, Kaufman R, Ron D, Harding H, Lehrman M. Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux. J Cell Biol. 2007;176:605-16 pubmed..Thus, by sensing ER stress from defective glycosylation, PERK can restore ER homeostasis by balancing polypeptide synthesis with flux through the LLO pathway. ..
- ..Potential contribution of these multiple activities of Klotho protein to aging processes is discussed. ..
- Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of presenilins in neuronal calcium homeostasis. J Neurosci. 2010;30:8566-80 pubmed publisher..These results indicate that disruption of ER Ca(2+) leak function of presenilins may play an important role in AD pathogenesis. ..
- Sohn J, Williams K. Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways. Mol Neurobiol. 2012;45:225-33 pubmed publisher..This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis. ..
- O Doherty R, Jensen P, Anderson P, Jones J, Berman H, Kearney D, et al. Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. J Clin Invest. 2000;105:479-88 pubmed..Because of its ability to enhance glucose storage without affecting other metabolic indicators, the glycogen-targeting subunit may prove valuable in controlling blood glucose levels in diabetes. ..
- Holder J, Zhang L, Kublaoui B, DiLeone R, Oz O, Bair C, et al. Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am J Physiol Endocrinol Metab. 2004;287:E105-13 pubmed..Our results indicate that Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat and likely plays a physiological role in the regulation of energy balance. ..
- Kasus Jacobi A, Ou J, Birch D, Locke K, Shelton J, Richardson J, et al. Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo. J Biol Chem. 2005;280:20413-20 pubmed..We propose that mRDH11 disruption affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptation through modulation of calcium homeostasis. ..
- Cummins C, Volle D, Zhang Y, McDonald J, Sion B, Lefrançois Martinez A, et al. Liver X receptors regulate adrenal cholesterol balance. J Clin Invest. 2006;116:1902-12 pubmed..These results imply LXRalpha provides a safety valve to limit free cholesterol levels as a basal protective mechanism in the adrenal gland, where cholesterol is under constant flux...
- Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee S, Hao Y, et al. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell. 2006;126:981-93 pubmed..The ER Ca(2+) leak function of presenilins is independent of their gamma-secretase activity. Our data suggest a Ca(2+) signaling function for presenilins and provide support for the "Ca(2+) hypothesis of AD." ..
- Iwasaki K, Levine B, Zhang R, Zuckerman J, Pawelczyk J, Diedrich A, et al. Human cerebral autoregulation before, during and after spaceflight. J Physiol. 2007;579:799-810 pubmed..We conclude that human cerebral autoregulation is preserved, and possibly even improved, by short-duration spaceflight. ..
- Xu Y, Jones J, Kohno D, Williams K, Lee C, Choi M, et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008;60:582-9 pubmed publisher..The findings also highlight the physiological relevance of the 5-HT2CR-melanocortin circuitry in the long-term regulation of energy balance. ..
- Wu X, Tu B. Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation. Mol Biol Cell. 2011;22:4124-33 pubmed publisher..Collectively, our findings have revealed the existence of additional mechanisms that regulate autophagy under previously unrecognized conditions, in response to relatively more subtle changes in metabolic and nutritional state. ..
- Frost R, Olson E. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A. 2011;108:21075-80 pubmed publisher..Furthermore, our Cre-inducible Let-7-transgenic mice provide a unique model for studying tissue-specific aspects of body growth and type 2 diabetes. ..
- Berglund E, Vianna C, Donato J, Kim M, Chuang J, Lee C, et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest. 2012;122:1000-9 pubmed publisher..Collectively, these results demonstrate that direct leptin action on POMC neurons does not reduce food intake, but is sufficient to normalize glucose and glucagon levels in mice otherwise lacking LEPR. ..
- Dravis C, Wu T, Chumley M, Yokoyama N, Wei S, Wu D, et al. EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph. Hear Res. 2007;223:93-104 pubmed
- Rogoff D, Ryder J, Black K, Yan Z, Burgess S, McMillan D, et al. Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase. Endocrinology. 2007;148:5072-80 pubmed..Comparison with other animal models of adrenal insufficiency suggests that many of the observed abnormalities can be explained by blunted intracellular corticosterone actions, despite elevated circulating levels of this hormone. ..
- Galler K, Yasue A, Cavender A, Bialek P, Karsenty G, D Souza R. A novel role for Twist-1 in pulp homeostasis. J Dent Res. 2007;86:951-5 pubmed..These findings suggest that Twist-1 plays a key role in restraining odontoblast differentiation, thus maintaining homeostasis in dental pulp. Furthermore, Twist-1 functions in dental pulp are dependent on its interaction with Runx2. ..