Experts and Doctors on histone acetyltransferases in Houston, Texas, United States

Summary

Locale: Houston, Texas, United States
Topic: histone acetyltransferases

Top Publications

  1. Narayanan R, Edwards D, Weigel N. Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. Mol Cell Biol. 2005;25:2885-98 pubmed
  2. Qin L, Liu Z, Chen H, Xu J. The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res. 2009;69:3819-27 pubmed publisher
    ..Therefore, SRC-1 promotes breast cancer invasiveness and metastasis by coactivating PEA3-mediated Twist expression. Intervention of SRC-1 function may provide new strategies to inhibit breast cancer metastasis. ..
  3. Bhattacharya S, Lou X, Hwang P, Rajashankar K, Wang X, Gustafsson J, et al. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc Natl Acad Sci U S A. 2014;111:9103-8 pubmed publisher
    ..Our findings could point toward novel roles for the TAF1-TAF7 complex in regulation of PIC assembly via reading epigenetic histone marks. ..
  4. Apostolakis E, Ramamurphy M, Zhou D, Onate S, O Malley B. Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice. Mol Endocrinol. 2002;16:1511-23 pubmed
    ..In the genetic, but not acute, absence of SRC-1, up-regulation of SRC-2 serves as a critical adaptive mechanism during female development. ..
  5. Liao L, Kuang S, Yuan Y, Gonzalez S, O Malley B, Xu J. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. J Steroid Biochem Mol Biol. 2002;83:3-14 pubmed
  6. Yi P, Wu R, Sandquist J, Wong J, Tsai S, Tsai M, et al. Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). Mol Cell Biol. 2005;25:9687-99 pubmed
  7. Liu Z, Liao L, Zhou S, Xu J. Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout. Int J Biol Sci. 2008;4:202-7 pubmed
    ..These results demonstrate that the floxed SRC-3 mouse lines have been successfully established. These mice will be useful for investigating the cell type- and developmental stage-specific functions of SRC-3. ..
  8. Prabhakaran M, Kelley R. A new strategy for isolating genes controlling dosage compensation in Drosophila using a simple epigenetic mosaic eye phenotype. BMC Biol. 2010;8:80 pubmed publisher
    ..This strategy is a promising alternative route for identifying previously unknown components of the dosage compensation pathway and novel alleles of known MSL proteins. ..
  9. Lin W, Srajer G, Evrard Y, Phan H, Furuta Y, Dent S. Developmental potential of Gcn5(-/-) embryonic stem cells in vivo and in vitro. Dev Dyn. 2007;236:1547-57 pubmed
    ..Collectively, these data indicate that Gcn5 may be required to maintain pluripotent states and that loss of Gcn5 invokes a cell-autonomous pathway of cell death in vivo. ..

More Information

Publications102 found, 100 shown here

  1. Le Gallo M, Rudd M, Urick M, Hansen N, Zhang S, Lozy F, et al. Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing. Cancer. 2017;123:3261-3268 pubmed publisher
    ..Our findings demonstrate molecular similarities between CCEC and SEC and EEC and implicate TAF1 as a novel candidate CCEC driver gene. Cancer 2017;123:3261-8. © 2017 American Cancer Society. ..
  2. Spencer T, Jenster G, Burcin M, Allis C, Zhou J, Mizzen C, et al. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature. 1997;389:194-8 pubmed
  3. Roth S, Denu J, Allis C. Histone acetyltransferases. Annu Rev Biochem. 2001;70:81-120 pubmed
    ..Although the functions of HATs and the mechanisms by which they are regulated are only beginning to be understood, these fundamental processes are likely to have far-reaching implications for human biology and disease. ..
  4. Feng Q, Yi P, Wong J, O Malley B. Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol. 2006;26:7846-57 pubmed
    ..We propose that CARM1 is a dual-function coactivator, as it not only activates transcription by modifying core histone tails but also terminates hormone signaling by disassembly of the coactivator complex. ..
  5. Yin S, Jiang X, Jiang H, Gao Q, Wang F, Fan S, et al. Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels. Development. 2017;144:2165-2174 pubmed publisher
    ..Taken together, our findings demonstrate that KAT8 is essential for female fertility by regulating antioxidant gene expression and identify KAT8 as the first histone acetyltransferase with an essential function in oogenesis. ..
  6. Smith C, DeVera D, Lamb D, Nawaz Z, Jiang Y, Beaudet A, et al. Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction. Mol Cell Biol. 2002;22:525-35 pubmed
  7. Tanaka T, Nishimura D, Wu R, Amano M, Iso T, Kedes L, et al. Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. J Biol Chem. 2006;281:15320-9 pubmed
    ..These observations suggest that nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity. ..
  8. Ning G, Jurecic V, Baldini A, Xu J. Structure and chromosomal locations of mouse steroid receptor coactivator gene family. In Vitro Cell Dev Biol Anim. 1999;35:481-6 pubmed
    ..This information is important for developing valuable animal models harboring multiple disruptions of the SRC gene family to study their biological functions. ..
  9. Liu Y, Nguyen C, Peleg S. Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor. Mol Endocrinol. 2000;14:1776-87 pubmed
    ..The mechanisms by which the two ligands expose these functional interfaces differ with respect to participation of the AF-2 domain. ..
  10. Huang Z, Li J, Wong J. AR possesses an intrinsic hormone-independent transcriptional activity. Mol Endocrinol. 2002;16:924-37 pubmed
    ..Altogether, our studies reveal that AR has a capacity to activate transcription in a ligand-independent manner. ..
  11. Edmondson D, Davie J, Zhou J, Mirnikjoo B, Tatchell K, Dent S. Site-specific loss of acetylation upon phosphorylation of histone H3. J Biol Chem. 2002;277:29496-502 pubmed
  12. Jaber B, Mukopadhyay R, Smith C. Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment. J Mol Endocrinol. 2004;32:307-23 pubmed
  13. Wong L, Dai P, Lu J, Lou M, Clarke R, Nazarov V. AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines. BMC Cancer. 2006;6:111 pubmed
    ..The instability and the sequence characteristics, however, do not appear to be associated with the level of the gene amplification. ..
  14. Gururaj A, Peng S, Vadlamudi R, Kumar R. Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1). Mol Endocrinol. 2007;21:1847-60 pubmed
    ..In brief, these results highlight a mechanism whereby ERalpha activation triggers a positive feedback loop leading to signal amplification in the cell. ..
  15. Lin W, Zhang Z, Chen C, Behringer R, Dent S. Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. Dev Growth Differ. 2008;50:321-30 pubmed publisher
    ..These data provide the first evidence that Gcn5 contributes to Hox gene regulation and is required for normal anteroposterior patterning of the mouse skeleton. ..
  16. Ayala G, Yan J, Li R, Ding Y, Thompson T, Mims M, et al. Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt. Clin Cancer Res. 2008;14:7511-8 pubmed publisher
    ..These data suggest that combined therapies targeting the proteasome and the Akt pathway may have increased efficacy. ..
  17. Campeau P, Kim J, Lu J, Schwartzentruber J, Abdul Rahman O, Schlaubitz S, et al. Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome. Am J Hum Genet. 2012;90:282-9 pubmed publisher
    ..Together, the data support an epigenetic dysregulation of the limb, brain, and genital developmental programs. ..
  18. Shi J, Wang Y, Zeng L, Wu Y, Deng J, Zhang Q, et al. Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. Cancer Cell. 2014;25:210-25 pubmed publisher
    ..Our study indicates that the interaction with BRD4 is critical for the oncogenic function of Twist in BLBC. ..
  19. Stenoien D, Cummings C, Adams H, Mancini M, Patel K, DeMartino G, et al. Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone. Hum Mol Genet. 1999;8:731-41 pubmed
    ..These results suggest that ARQ48 accumulates due to protein misfolding and a breakdown in proteolytic processing. Furthermore, the homeostatic disturbances associated with aggregate formation may affect normal cell function. ..
  20. Nishihara E, Yoshida Komiya H, Chan C, Liao L, Davis R, O Malley B, et al. SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells. J Neurosci. 2003;23:213-22 pubmed
    ..Disruption of SRC-1 specifically delays the PC development and maturation in early stages and results in moderate motor dysfunction in adulthood. ..
  21. Deng W, Wu K. Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J Immunol. 2003;171:6581-8 pubmed
    ..We conclude that p300 is essential for iNOS transcription. Our results suggest that p300 HAT acetylates the p50 subunit of NF-kappaB, thereby increasing NF-kappaB binding and NF-kappaB mediated transactivation. ..
  22. Smith C, Nawaz Z, O Malley B. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol. 1997;11:657-66 pubmed
  23. Onate S, Boonyaratanakornkit V, Spencer T, Tsai S, Tsai M, Edwards D, et al. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. J Biol Chem. 1998;273:12101-8 pubmed
  24. Ran Q, Pereira Smith O. Identification of an alternatively spliced form of the Tat interactive protein (Tip60), Tip60(beta). Gene. 2000;258:141-6 pubmed
    ..The results suggest that Tip60beta may have functions additional to those of Tip60alpha in cells and tissues. ..
  25. Ma Z, Liu Z, Ngan E, Tsai S. Cdc25B functions as a novel coactivator for the steroid receptors. Mol Cell Biol. 2001;21:8056-67 pubmed
    ..This dual function might likely contribute to its oncogenic action in breast cancer. ..
  26. Chen Q, Dowhan D, Liang D, Moore D, Overbeek P. CREB-binding protein/p300 co-activation of crystallin gene expression. J Biol Chem. 2002;277:24081-9 pubmed
    ..In a promoter-specific fashion, co-activation can be modulated by Prox-1 and/or Sox-1. This modulation may help to specify the endogenous levels of crystallin gene expression. ..
  27. Pardo P, Leung J, Lucchesi J, Pereira Smith O. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. J Biol Chem. 2002;277:50860-6 pubmed
    ..The various mechanisms by which MRG15 could activate gene transcription are discussed. ..
  28. Wu R, Qin J, Yi P, Wong J, Tsai S, Tsai M, et al. Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell. 2004;15:937-49 pubmed
    ..Our results uncovered an additional level of transcriptional regulation whereby specific modulations of SRC-3 phosphorylation allow this coactivator to function as a regulatable integrator for diverse signaling pathways in cells. ..
  29. Ye X, Han S, Tsai S, DeMayo F, Xu J, Tsai M, et al. Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. Proc Natl Acad Sci U S A. 2005;102:9487-92 pubmed
    ..Our results provide unique in vivo insights to the multidimensional cell-type-specific interactions between AR and coregulators. ..
  30. Yu C, York B, Wang S, Feng Q, Xu J, O Malley B. An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response. Mol Cell. 2007;25:765-78 pubmed
    ..Collectively, our studies reveal an essential function of SRC-3 as a coordinator of inflammatory mRNA translation and as a physiologic protective factor against the lethal endotoxic shock triggered by an acute inflammatory response. ..
  31. Liao L, Chen X, Wang S, Parlow A, Xu J. Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression. Mol Cell Biol. 2008;28:2460-9 pubmed publisher
    ..In agreement with the role of SRC-3 in VDR function, the expression of several VDR target genes was also reduced in SRC-3(-/-) mice. Therefore, SRC-3 maintains IGF-I in the circulation through enhancing VDR-regulated IGFBP-3 expression. ..
  32. Zheng F, Wu R, Smith C, O Malley B. Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol Cell Biol. 2005;25:8273-84 pubmed
    ..Our results provide evidence for an early nongenomic action of ER on SRC-3 that supports the well-established downstream genomic roles of estrogen and coactivators. ..
  33. Yasumoto H, Meng L, Lin T, Zhu Q, Tsai R. GNL3L inhibits activity of estrogen-related receptor gamma by competing for coactivator binding. J Cell Sci. 2007;120:2532-43 pubmed
    ..This work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma by GNL3L through coactivator competition. ..
  34. Duong M, Akli S, Macalou S, Biernacka A, Debeb B, Yi M, et al. Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells. Cancer Res. 2013;73:5556-68 pubmed publisher
    ..Collectively, our results suggest that the heightened oncogenecity of LMW-E relates to its ability to promote CSC properties, supporting the design of therapeutic strategies to target this unique function. ..
  35. Xu J, Liao L, Ning G, Yoshida Komiya H, Deng C, O Malley B. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A. 2000;97:6379-84 pubmed
    ..These results suggest that the physiological role of SRC-3 is different from that of SRC-1 and prove the diversity among coactivator family members. ..
  36. Zhou G, Hashimoto Y, Kwak I, Tsai S, Tsai M. Role of the steroid receptor coactivator SRC-3 in cell growth. Mol Cell Biol. 2003;23:7742-55 pubmed
    ..Similarly, in SRC-3 null mutant mice, AKT signaling is down-regulated in normally SRC-3-expressing tissues. Taken together, these results suggest that SRC-3 is an important modulator for mammalian cell growth. ..
  37. Han S, DeMayo F, Xu J, Tsai S, Tsai M, O Malley B. Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol. 2006;20:45-55 pubmed
    ..SRC-3 is the primary coactivator for PR in breast and SRC-1 is the primary coactivator for PR in uterus. ..
  38. Mussi P, Yu C, O Malley B, Xu J. Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3. Mol Endocrinol. 2006;20:3105-19 pubmed
  39. Yan J, Yu C, Ozen M, Ittmann M, Tsai S, Tsai M. Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway. Cancer Res. 2006;66:11039-46 pubmed
    ..Taken together, our results clearly show that SRC-3 and AP-1 can coordinately regulate the transcription of multiple components in the IGF/AKT pathway to ensure ligand-independent cell proliferation and survival of cancer cells. ..
  40. Xu J, Wu R, O Malley B. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer. 2009;9:615-30 pubmed publisher
    ..These studies have identified new challenges for cancer research and therapy. ..
  41. Wang J, Chen J. SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem. 2010;285:11458-64 pubmed publisher
    ..Taken together, our data reveal TIP60 autoacetylation as a key step in the control of its histone acetyltransferase activity and function in response to DNA damage. ..
  42. Wilson M, Koutelou E, Hirsch C, Akdemir K, Schibler A, Barton M, et al. Ubp8 and SAGA regulate Snf1 AMP kinase activity. Mol Cell Biol. 2011;31:3126-35 pubmed publisher
    ..Overall, our data indicate that SAGA modulates the posttranslational modifications of Snf1 in order to fine-tune gene expression levels. ..
  43. Campeau P, Lu J, Dawson B, Fokkema I, Robertson S, Gibbs R, et al. The KAT6B-related disorders genitopatellar syndrome and Ohdo/SBBYS syndrome have distinct clinical features reflecting distinct molecular mechanisms. Hum Mutat. 2012;33:1520-5 pubmed publisher
    ..LOVD.nl/KAT6B) might help tease out answers to these questions and understand the developmental programs dysregulated by the different truncations. ..
  44. Onate S, Tsai S, Tsai M, O Malley B. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science. 1995;270:1354-7 pubmed
    ..Together, these results indicate that SRC-1 encodes a coactivator that is required for full transcriptional activity of the steroid receptor superfamily. ..
  45. Xu J, Li Q. Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol Endocrinol. 2003;17:1681-92 pubmed
    ..Furthermore, this article also reviews our current understanding of the role of SRC-3 in breast cancer and discusses possible mechanisms for functional specificity and redundancy among SRC family members. ..
  46. Louet J, Coste A, Amazit L, Tannour Louet M, Wu R, Tsai S, et al. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci U S A. 2006;103:17868-73 pubmed
    ..Collectively, these data suggest a crucial role for SRC-3 as an integrator of the complex transcriptional network controlling adipogenesis. ..
  47. Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, et al. The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol. 2008;28:5937-50 pubmed publisher
    ..These findings suggest a new alternative strategy for controlling the deleterious roles of these MMPs in breast cancer by inhibiting their upstream coregulator AIB1. ..
  48. Agoulnik I, Weigel N. Coactivator selective regulation of androgen receptor activity. Steroids. 2009;74:669-74 pubmed publisher
    ..These data indicate that different groups of AR target genes have distinct requirements for coactivators and response to AR ligands. ..
  49. Geng J, Yu S, Zhao H, Sun X, Li X, Wang P, et al. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol. 2017;18:800-812 pubmed publisher
    ..Our results demonstrate a pivotal role for TAZ in regulating the differentiation of Treg cells and TH17 cells. ..
  50. McKenna N, Nawaz Z, Tsai S, Tsai M, O Malley B. Distinct steady-state nuclear receptor coregulator complexes exist in vivo. Proc Natl Acad Sci U S A. 1998;95:11697-702 pubmed
    ..Our results suggest that the assembly of large, modular transcriptional complexes by recruitment of distinct subclasses of preformed coregulator subcomplexes may be involved in transcriptional regulation by activated nuclear receptors. ..
  51. Lanz R, McKenna N, Onate S, Albrecht U, Wong J, Tsai S, et al. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999;97:17-27 pubmed
    ..We suggest that SRA may act to confer functional specificity upon multiprotein complexes recruited by liganded receptors during transcriptional activation. ..
  52. Urizar N, Liverman A, Dodds D, Silva F, Ordentlich P, Yan Y, et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002;296:1703-6 pubmed
    ..Other natural products with specific biologic effects may modulate the activity of FXR or other relatively promiscuous nuclear hormone receptors. ..
  53. Mark M, Yoshida Komiya H, Gehin M, Liao L, Tsai M, O Malley B, et al. Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction. Proc Natl Acad Sci U S A. 2004;101:4453-8 pubmed
  54. Sung B, Pandey M, Ahn K, Yi T, Chaturvedi M, Liu M, et al. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of . Blood. 2008;111:4880-91 pubmed publisher
    ..Overall, our results demonstrate a novel role for anacardic acid in potentially preventing or treating cancer through modulation of NF-kappaB signaling pathway. ..
  55. Zhu Y, Saunders M, Yeh H, Deng W, Wu K. Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins. J Biol Chem. 2002;277:6923-8 pubmed
    ..These findings provide new insight into the regulation of cyclooxygenase-2 promoter by an interplay between two opposite beta isoforms and p300 co-activator. ..
  56. Chen Q, Ash J, Branton P, Fromm L, Overbeek P. Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene. 2002;21:1028-37 pubmed
  57. Phan D, Cheng C, Galfione M, Vakar Lopez F, Tunstead J, Thompson N, et al. Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. Cancer Res. 2004;64:3072-8 pubmed
    ..Our studies show that transcriptional repression by Sp2 represents one mechanism by which CEACAM1 tumor suppressor gene is down-regulated in prostate cancer. ..
  58. Amazit L, Pasini L, Szafran A, Berno V, Wu R, Mielke M, et al. Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation. Mol Cell Biol. 2007;27:6913-32 pubmed
    ..Technically and conceptually, these findings have a new and broad impact upon evaluating mechanisms of action of gene regulators at a cellular system level. ..
  59. Xu W, Edmondson D, Evrard Y, Wakamiya M, Behringer R, Roth S. Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet. 2000;26:229-32 pubmed
    ..Our studies are the first to demonstrate that specific acetyltransferases are required for cell survival and mesoderm formation during mammalian development. ..
  60. Narayanan R, Adigun A, Edwards D, Weigel N. Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator. Mol Cell Biol. 2005;25:264-77 pubmed
  61. Wang S, Yuan Y, Liao L, Kuang S, Tien J, O Malley B, et al. Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci U S A. 2009;106:151-6 pubmed publisher
    ..Therefore, functional interventions for coactivators like SRC-1 may provide unique approaches to control breast cancer progression and metastasis. ..
  62. Xu J, Qiu Y, DeMayo F, Tsai S, Tsai M, O Malley B. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science. 1998;279:1922-5 pubmed
    ..The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone. ..
  63. Zhang W, Bone J, Edmondson D, Turner B, Roth S. Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase. EMBO J. 1998;17:3155-67 pubmed
  64. Xu W, Edmondson D, Roth S. Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol. 1998;18:5659-69 pubmed
    ..Thus, the unique amino-terminal domains of mammalian P/CAF and GCN5 may provide additional functions important to recognition of chromatin substrates and the regulation of gene expression. ..
  65. Dutertre M, Smith C. Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains. Mol Endocrinol. 2003;17:1296-314 pubmed
  66. Li X, Lonard D, Jung S, Malovannaya A, Feng Q, Qin J, et al. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell. 2006;124:381-92 pubmed
    ..It also highlights the fact that an alternative mode of proteasome-mediated protein degradation, independent of the 19S proteasome regulatory cap, targets the SRC-3 protein for degradation. ..
  67. Bu P, Evrard Y, Lozano G, Dent S. Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol. 2007;27:3405-16 pubmed
    ..Together, our results indicate that Gcn5 has important, HAT-independent functions in early development and that Gcn5 acetyltransferase activity is required for cranial neural tube closure in the mouse. ..
  68. Chung A, Zhou S, Liao L, Tien J, Greenberg N, Xu J. Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice. Cancer Res. 2007;67:5965-75 pubmed
    ..Inhibition of AIB1 expression or function in the prostate epithelium may be a potential strategy to suppress prostate cancer initiation and progression. ..
  69. Yi P, Feng Q, Amazit L, Lonard D, Tsai S, Tsai M, et al. Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell. 2008;29:465-76 pubmed publisher
    ..Our results demonstrate a potent signaling mechanism for regulating SRC-3 levels in cells by coordinate enzymatic inhibition of both ubiquitin-dependent and ubiquitin-independent proteolytic pathways. ..
  70. Liu Z, Wong J, Tsai S, Tsai M, O Malley B. Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. Proc Natl Acad Sci U S A. 1999;96:9485-90 pubmed
  71. Rowan B, Weigel N, O Malley B. Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway. J Biol Chem. 2000;275:4475-83 pubmed
    ..These results identify phosphorylation as a regulatory modification of SRC-1 and provide a basis upon which to identify signaling pathways that regulate SRC-1 function and, consequently, modify steroid/nuclear receptor action. ..
  72. Book McAlexander M, Yu Lee L. Prolactin activation of IRF-1 transcription involves changes in histone acetylation. FEBS Lett. 2001;488:91-4 pubmed
    ..These results demonstrate a correlation between histone H4 hyperacetylation at the IRF-1 promoter and biphasic transcription of IRF-1 in response to PRL signaling in vivo. ..
  73. Liu Z, Wong J, Tsai S, Tsai M, O Malley B. Sequential recruitment of steroid receptor coactivator-1 (SRC-1) and p300 enhances progesterone receptor-dependent initiation and reinitiation of transcription from chromatin. Proc Natl Acad Sci U S A. 2001;98:12426-31 pubmed
    ..Efficient recruitment of p300 required the presence of SRC-1. In addition, functional analysis of SRC-2 and SRC-3 coactivators indicated that the SRC family modulated PR transactivation from chromatin by a similar mechanism. ..
  74. Cavarretta I, Mukopadhyay R, Lonard D, Cowsert L, Bennett C, O Malley B, et al. Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. Mol Endocrinol. 2002;16:253-70 pubmed
  75. Wu R, Qin J, Hashimoto Y, Wong J, Xu J, Tsai S, et al. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol. 2002;22:3549-61 pubmed
    ..Taken together, our results not only reveal the IKK-mediated phosphorylation of SRC-3 to be a regulated event that plays an important role but also substantiate the role of SRC-3 in multiple signaling pathways. ..
  76. Kuang S, Liao L, Zhang H, Lee A, O Malley B, Xu J. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 2004;64:1875-85 pubmed
    ..These results suggest that a more effective strategy to control breast cancer is to target AIB1-mediated and ovarian hormone-initiated pathways. ..
  77. Han S, Jeong J, DeMayo F, Xu J, Tsai S, Tsai M, et al. Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice. Mol Cell Biol. 2005;25:8150-65 pubmed
  78. Agoulnik I, Vaid A, Bingman W, Erdeme H, Frolov A, Smith C, et al. Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression. Cancer Res. 2005;65:7959-67 pubmed
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    ..This study demonstrates that the molecular targets of SRC-2 regulation in the murine liver stimulate fatty acid degradation and glycolytic pathway, whereas fatty acid, cholesterol, and steroid biosynthetic pathways are down-regulated. ..
  80. Yuan Y, Xu J. Loss-of-function deletion of the steroid receptor coactivator-1 gene in mice reduces estrogen effect on the vascular injury response. Arterioscler Thromb Vasc Biol. 2007;27:1521-7 pubmed
    ..SRC-1 is expressed in ECs, VSMCs, and neointima cells. SRC-1 expression in these cells facilitates estrogen/ER-mediated vasoprotection through the inhibition of neointima formation after a vascular injury. ..
  81. Lonard D, O Malley B. SRC-3 transcription-coupled activation, degradation, and the ubiquitin clock: is there enough coactivator to go around in cells?. Sci Signal. 2008;1:pe16 pubmed publisher
    ..Precise control of the cellular concentration of SRC-3 may thus serve as a mechanism for defining growth responses to estrogen receptors and other growth-promoting transcription factors. ..
  82. Tien J, Zhou S, Xu J. The role of SRC-1 in murine prostate cancinogenesis is nonessential due to a possible compensation of SRC-3/AIB1 overexpression. Int J Biol Sci. 2009;5:256-64 pubmed
    ..Therefore, the loss of SRC-1 function may be compensated by SRC-3 overexpression during prostate tumorigenesis in SRC-1(-/-) mice. ..
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    ..Since Mig-6 is regulated by both PR and SRC-1, this identifies a PR, SRC-1, Mig-6 regulatory pathway that is critical in the suppression of endometrial cancer. ..
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    ..These functions are essential for normal embryo development in flies and mice, and mutations or altered expression of SAGA subunits correlate with neurological disease and aggressive cancers in humans. ..
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    ..Although many inactivating mutations have been identified in androgen insensitivity syndrome patients, to our knowledge, this is the first characterization of an inactivating mutation identified in human prostate cancer. ..
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    ..Our study supports the idea that SRF embryonic cardiac gene expression is dependent upon the SRF 3'-UTR enhancer, Tbx2, Tbx5, and TIP60 histone acetyltransferase activity. ..
  88. Phan H, Xu A, Coco C, Srajer G, Wyszomierski S, Evrard Y, et al. GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005;233:1337-47 pubmed
    ..Our data indicate that p300 cooperates specifically with GCN5 to provide essential functions during early embryogenesis. ..
  89. Hossain A, Kuo M, Saunders G. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol. 2006;26:8191-201 pubmed
    ..Mir-17-5p also completely abrogated the insulin-like growth factor 1-mediated, anchorage-independent growth of breast cancer cells. Our results reveal that Mir-17-5p has a role as a tumor suppressor in breast cancer cells. ..
  90. Jeong J, Lee K, Han S, Aronow B, Lydon J, O Malley B, et al. The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression. Endocrinology. 2007;148:4238-50 pubmed
    ..This analysis indicates that SRC-2 regulates uterine function by modulating the regulation of developmentally important signaling molecules and the ability of P4 to repress specific genes. ..
  91. Wu R, Feng Q, Lonard D, O Malley B. SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell. 2007;129:1125-40 pubmed
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