Experts and Doctors on high mobility group proteins in Dallas, Texas, United States
Locale: Dallas, Texas, United States
Topic: high mobility group proteins
Lo M, Gay F, Odom R, Shi Y, Lin R. Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans. Cell. 2004;117:95-106 pubmed
..Our results suggest a model whereby Wnt/MAPK signaling downregulates POP-1 levels in responsive cells, in part by increasing nuclear LIT-1 levels, thereby increasing POP-1 phosphorylation and PAR-5-mediated nuclear export. ..
Shetty P, Lo M, Robertson S, Lin R. C. elegans TCF protein, POP-1, converts from repressor to activator as a result of Wnt-induced lowering of nuclear levels. Dev Biol. 2005;285:584-92 pubmed
..We propose that the balance between TCF/LEF and coactivator(s), achieved by elevating coactivator levels (the canonical pathway) and/or reducing TCF/LEF levels (worm endoderm), determines Wnt signal strength. ..
Huang S, Shetty P, Robertson S, Lin R. Binary cell fate specification during C. elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator beta-catenin SYS-1. Development. 2007;134:2685-95 pubmed
..We propose that two genetic pathways, one increasing SYS-1 and the other decreasing POP-1 levels, robustly elevate the SYS-1-to-POP-1 ratio in the posterior cell, thereby driving A-P differential cell fates. ..
Yang X, Huang S, Lo M, Mizumoto K, Sawa H, Xu W, et al
. Distinct and mutually inhibitory binding by two divergent ?-catenins coordinates TCF levels and activity in C. elegans. Development. 2011;138:4255-65 pubmed publisher
..These studies could provide novel insights into cancers arising from aberrant Wnt activation. ..
Liu X, Zhang Y, Ni M, Cao H, Signer R, Li D, et al
. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nat Cell Biol. 2017;19:626-638 pubmed publisher
..Our studies support a mechanism for post-transcriptional control of erythroid mitochondria and may have direct relevance to haematologic defects associated with mitochondrial diseases and ageing. ..
Liu X, Dang Y, Matsu ura T, He Y, He Q, Hong C, et al
. DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Mol Cell. 2017;67:203-213.e4 pubmed publisher
..Together, these results establish circadian clock and cell cycle as interdependent coupled oscillators and identify DNA replication as a critical process in the circadian mechanism. ..
McIntosh L, Marion M, Sudman M, Comeau M, Becker M, Bohnsack J, et al
. Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. Arthritis Rheumatol. 2017;69:2222-2232 pubmed publisher
..Thus, they likely represent regions that contribute to the pathology of oligoarticular JIA and RF-negative polyarticular JIA. ..
Zelenaya Troitskaya O, Newman S, Okamoto K, Perlman P, Butow R. Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae. Genetics. 1998;148:1763-76 pubmed
..These findings are discussed in the context of a model relating mtDNA copy number control and stability to mtDNA recombination. ..
Spencer J, Baron M, Olson E. Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. J Biol Chem. 1999;274:15686-93 pubmed
..These results reveal an important role for SSRP1 as a coregulator of SRF-dependent transcription in mammalian cells. ..