Experts and Doctors on dna binding proteins in Dallas, Texas, United States


Locale: Dallas, Texas, United States
Topic: dna binding proteins

Top Publications

  1. Brown L, Espinosa R, Le Beau M, Siciliano M, Baer R. HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Proc Natl Acad Sci U S A. 1992;89:8492-6 pubmed
    ..These data imply that the bHLH protein subgroup encoded by HEN1 and HEN2 may serve important regulatory functions in the developing nervous system. ..
  2. Zelenaya Troitskaya O, Perlman P, Butow R. An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. EMBO J. 1995;14:3268-76 pubmed
    ..We suggest that ILV5 encodes a bifunctional protein required for branched-chain amino acid biosynthesis and for the maintenance of rho+ mtDNA. ..
  3. Melcher K, Johnston S. GAL4 interacts with TATA-binding protein and coactivators. Mol Cell Biol. 1995;15:2839-48 pubmed
    ..This suggests that these two prototypic activators make similar contacts with TBP. ..
  4. Shin E, Perryman L, Meek K. A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. J Immunol. 1997;158:3565-9 pubmed
  5. Ou J, Tu H, Shan B, Luk A, DeBose Boyd R, Bashmakov Y, et al. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci U S A. 2001;98:6027-32 pubmed
    ..These data offer a potential mechanism that partially explains the long-known ability of dietary unsaturated fatty acids to decrease the synthesis and secretion of fatty acids and triglycerides in livers of humans and other animals. ..
  6. Janowski B. The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP. Proc Natl Acad Sci U S A. 2002;99:12675-80 pubmed
    ..Taken together, these data suggest that INSIG-1 plays a critical role in regulating cholesterol concentrations in the cell. ..
  7. Chai W, Ford L, Lenertz L, Wright W, Shay J. Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem. 2002;277:47242-7 pubmed
    ..The results presented here are the first to report that Ku associates with hTERT, and this interaction may function to regulate the access of telomerase to telomeric DNA ends. ..
  8. Bruick R. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. Genes Dev. 2003;17:2614-23 pubmed
  9. Yang G, Ge H, Boucher A, Yu X, Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol. 2004;18:1354-62 pubmed
    ..Because plasma SLR levels are independently regulated by many different physiological and pathophysiological conditions, SLR may modulate the actions of leptin in tissues in which direct action of leptin has been demonstrated. ..

More Information

Publications137 found, 100 shown here

  1. Zhang Q, Zhang L, Wang B, Ou C, Chien C, Jiang J. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell. 2006;10:719-29 pubmed
    ..We provide evidence that HIB prevents aberrant Hh signaling posterior to the morphogenic furrow, which is essential for normal eye development. ..
  2. Creemers E, Sutherland L, McAnally J, Richardson J, Olson E. Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development. Development. 2006;133:4245-56 pubmed
  3. Ouyang Z, Kumar M, Kariu T, Haq S, Goldberg M, Pal U, et al. BosR (BB0647) governs virulence expression in Borrelia burgdorferi. Mol Microbiol. 2009;74:1331-43 pubmed publisher
    ..This study thus not only has elucidated another key virulence gene of Bb, but also provides new insights into a previously unknown layer of gene regulation governing RpoS in Bb. ..
  4. Dempsey W, Fee B. Integration host factor affects expression of two genes at the conjugal transfer origin of plasmid R100. Mol Microbiol. 1990;4:1019-28 pubmed
    ..Transcript analyses by Northern blots showed a reduction in size of the principal gene X and traJ transcripts in the absence of IHF. ..
  5. Seeler J, Muchardt C, Suessle A, Gaynor R. Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. J Virol. 1994;68:1002-9 pubmed
    ..These results are consistent with a role for PRDII-BF1 in activating HIV-1 gene expression. ..
  6. Cheng J, Hsu H, Hwang L, Baer R. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. Oncogene. 1993;8:677-83 pubmed
    ..Therefore, TAL1 activation may promote leukemogenesis in a far greater proportion of T-ALL patients than the 30% that bear gross TAL1 gene rearrangements. ..
  7. Yang Q, Bassel Duby R, Williams R. Transient expression of a winged-helix protein, MNF-beta, during myogenesis. Mol Cell Biol. 1997;17:5236-43 pubmed
  8. Lu J, Webb R, Richardson J, Olson E. MyoR: a muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD. Proc Natl Acad Sci U S A. 1999;96:552-7 pubmed
    ..These results suggest a role for MyoR as a lineage-restricted transcriptional repressor of the muscle differentiation program. ..
  9. Repa J, Lund E, Horton J, Leitersdorf E, Russell D, Dietschy J, et al. Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J Biol Chem. 2000;275:39685-92 pubmed
    ..These studies confirm the importance of CYP27 in bile acid synthesis and they reveal an unexpected function of the enzyme in triacylglycerol metabolism. ..
  10. Zhang C, McKinsey T, Lu J, Olson E. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001;276:35-9 pubmed
    ..These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. ..
  11. Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci U S A. 2001;98:13710-5 pubmed
    ..These results thus reveal mechanisms for regulation of ChREBP and the L-PK transcription by excess carbohydrate and cAMP. ..
  12. Chung G, Edwards A, Schimmenti L, Manligas G, Zhang Y, Ritter R. Renal-coloboma syndrome: report of a novel PAX2 gene mutation. Am J Ophthalmol. 2001;132:910-4 pubmed
    ..Awareness of the systemic associations with optic nerve abnormalities and the ocular findings in syndromic renal diseases will facilitate the management of these highly variable disorders. ..
  13. Rawson R. The SREBP pathway--insights from Insigs and insects. Nat Rev Mol Cell Biol. 2003;4:631-40 pubmed
  14. Gocke C, Yu H, Kang J. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem. 2005;280:5004-12 pubmed
    ..Therefore, sumoylation appears to regulate the functions of its substrates through multiple, context-dependent mechanisms. ..
  15. Gazdar A. DNA repair and survival in lung cancer--the two faces of Janus. N Engl J Med. 2007;356:771-3 pubmed
  16. Bhatia P, Verhage R, Brouwer J, Friedberg E. Molecular cloning and characterization of Saccharomyces cerevisiae RAD28, the yeast homolog of the human Cockayne syndrome A (CSA) gene. J Bacteriol. 1996;178:5977-88 pubmed
    ..Both rad28 and rad26 null mutants are hypermutable following exposure to UV light. ..
  17. Carrington E, Jones R. The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution. Development. 1996;122:4073-83 pubmed
    ..Finally, we describe the effect a trithorax mutation has on E(Z) chromosome binding. ..
  18. Jia Y, Rothermel B, Thornton J, Butow R. A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol. 1997;17:1110-7 pubmed
    ..The basic region of Rtg3p conforms well to the basic region of most bHLH proteins, whereas the basic region of Rtg1p does not. These findings suggest that the Rtg1p-Rtg3p complex interacts in a novel way with its DNA target sites. ..
  19. Black B, Lu J, Olson E. The MEF2A 3' untranslated region functions as a cis-acting translational repressor. Mol Cell Biol. 1997;17:2756-63 pubmed
  20. Srivastava D, Thomas T, Lin Q, Kirby M, Brown D, Olson E. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet. 1997;16:154-60 pubmed
  21. Cao G, Garcia C, Wyne K, Schultz R, Parker K, Hobbs H. Structure and localization of the human gene encoding SR-BI/CLA-1. Evidence for transcriptional control by steroidogenic factor 1. J Biol Chem. 1997;272:33068-76 pubmed
  22. Thomas T, Yamagishi H, Overbeek P, Olson E, Srivastava D. The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev Biol. 1998;196:228-36 pubmed
  23. Liu L, Kwak Y, Bex F, García Martínez L, Li X, Meek K, et al. DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties. Mol Cell Biol. 1998;18:4221-34 pubmed
    ..These results suggest that DNA-PK phosphorylation of IkappaB alpha increases its interaction with NF-kappaB to reduce NF-kappaB DNA binding properties. ..
  24. Reed S, You Z, Friedberg E. The yeast RAD7 and RAD16 genes are required for postincision events during nucleotide excision repair. In vitro and in vivo studies with rad7 and rad16 mutants and purification of a Rad7/Rad16-containing protein complex. J Biol Chem. 1998;273:29481-8 pubmed
    ..We conclude that the products of the RAD7 and RAD16 genes are involved in a postincision event(s) during NER in yeast. ..
  25. Chelstowska A, Liu Z, Jia Y, Amberg D, Butow R. Signalling between mitochondria and the nucleus regulates the expression of a new D-lactate dehydrogenase activity in yeast. Yeast. 1999;15:1377-91 pubmed
    ..Our data thus provide gene assignments for two previously unrecognized D-lactate dehydrogenase activities in yeast. ..
  26. Wang G, Amanai K, Wang B, Jiang J. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev. 2000;14:2893-905 pubmed
    ..Finally, we show that Cos2 is required for transducing high levels of Hh signaling activity, and it does so by alleviating the blockage of Ci activity imposed by Su(fu). ..
  27. Russell S, Johnston S. Evidence that proteolysis of Gal4 cannot explain the transcriptional effects of proteasome ATPase mutations. J Biol Chem. 2001;276:9825-31 pubmed
    ..These findings suggest that the 19S regulatory complex may play a more direct role in transcription. ..
  28. Jeong C, Yang S, Xie Y, Zhang L, Johnston S, Kodadek T. Evidence that Gal11 protein is a target of the Gal4 activation domain in the mediator. Biochemistry. 2001;40:9421-7 pubmed
  29. Zhao L, Bakke M, Parker K. Pituitary-specific knockout of steroidogenic factor 1. Mol Cell Endocrinol. 2001;185:27-32 pubmed
    ..The pituitary-specific SF-1 knockout mice are a novel genetic model of hypogonadotropic hypogonadism and establish essential roles of SF-1 in gonadotropin expression. ..
  30. Cheng P, Yang Y, Gardner K, Liu Y. PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses of Neurospora. Mol Cell Biol. 2002;22:517-24 pubmed
    ..Such interactions are essential for maintaining the steady-state level of WC-1 and the proper function of WC-1 and WC-2 in circadian clock and light responses...
  31. Seegmiller A, Dobrosotskaya I, Goldstein J, Ho Y, Brown M, Rawson R. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell. 2002;2:229-38 pubmed
    ..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis. ..
  32. Yabe D, Xia Z, Adams C, Rawson R. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols. Proc Natl Acad Sci U S A. 2002;99:16672-7 pubmed publisher
    ..Thus, three different point mutations, each within the sterol-sensing domain of SCAP, prevent sterol-induced binding of SCAP to insig proteins and abolish feedback regulation of SREBP processing by sterols...
  33. Ramirez R, Herbert B, Vaughan M, Zou Y, Gandia K, Morales C, et al. Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells. Oncogene. 2003;22:433-44 pubmed
    ..These results suggest that the differentiation pathways in Cdk4-overexpressing cells remain intact. ..
  34. Li J, Takaishi K, Cook W, McCorkle S, Unger R. Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes. Proc Natl Acad Sci U S A. 2003;100:9476-81 pubmed
    ..The results suggest that insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes. ..
  35. Lee J, Ye J. Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. J Biol Chem. 2004;279:45257-65 pubmed
    ..The current study demonstrates that animal cells, in response to either hypotonic shock or ER stress, can bypass the cholesterol inhibition of SREBP processing, an effect that is attributable to the rapid turnover of Insig-1. ..
  36. Foster D. The role of the carnitine system in human metabolism. Ann N Y Acad Sci. 2004;1033:1-16 pubmed
    ..Activation of fatty acid oxidation has considerable clinical promise for the treatment of obesity, type 2 diabetes, steatohepatitis, and lipotoxic damage to the heart. ..
  37. Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, et al. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell. 2005;9:819-30 pubmed
    ..We propose that phosphorylation of Ci by CKI creates multiple Slimb/beta-TRCP binding sites that act cooperatively to recruit SCF(Slimb/beta-TRCP). ..
  38. Cummins C, Volle D, Zhang Y, McDonald J, Sion B, Lefrançois Martinez A, et al. Liver X receptors regulate adrenal cholesterol balance. J Clin Invest. 2006;116:1902-12 pubmed
    ..These results imply LXRalpha provides a safety valve to limit free cholesterol levels as a basal protective mechanism in the adrenal gland, where cholesterol is under constant flux...
  39. Boland C, Koi M, Chang D, Carethers J. The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside. Fam Cancer. 2008;7:41-52 pubmed
  40. Kinkel T, McIver K. CcpA-mediated repression of streptolysin S expression and virulence in the group A streptococcus. Infect Immun. 2008;76:3451-63 pubmed publisher
    ..Thus, CcpA acts to repress SLS activity and virulence during systemic infection in mice, revealing an important link between carbon metabolism and GAS pathogenesis. ..
  41. Guo Y, Yang M, Weissler J, Yang Y. Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. Biochem Biophys Res Commun. 2008;374:570-5 pubmed publisher
    ..Taken together, our data suggests that Ubc9 can function as a co-factor of PLAGL2, uncoupling from its enzymatic activity, to mediate PLAGL2 interactive SP-C promoter activity. ..
  42. Shimomura I, Shimano H, Horton J, Goldstein J, Brown M. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest. 1997;99:838-45 pubmed
    ..2-fold), and the 1c transcript remained virtually undetectable. We conclude that the SREBP-1a and 1c transcripts are controlled independently by regulatory regions that respond differentially to organ-specific and metabolic factors...
  43. McKinsey T, Zhang C, Olson E. Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. Proc Natl Acad Sci U S A. 2000;97:14400-5 pubmed
    ..Our studies suggest that 14-3-3 binding to HDAC5 is required for CaMK-dependent disruption of MEF2-HDAC complexes and nuclear export of HDAC5, and implicate 14-3-3 as a signal-dependent regulator of muscle cell differentiation. ..
  44. Yang J, Goldstein J, Hammer R, Moon Y, Brown M, Horton J. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci U S A. 2001;98:13607-12 pubmed
    ..These data raise the possibility that S1P inhibitors may be effective lipid-lowering agents, but they suggest that nearly complete inhibition will be required. ..
  45. Cui Y, Huang L, Elefteriou F, Yang G, Shelton J, Giles J, et al. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol. 2004;24:258-69 pubmed
    ..These data thus suggest that loss of STAT3 in the hypothalamus caused by RIP-Cre action likely interferes with normal body weight homeostasis and glucose metabolism. ..
  46. Lu J, Bassel Duby R, Hawkins A, Chang P, Valdez R, Wu H, et al. Control of facial muscle development by MyoR and capsulin. Science. 2002;298:2378-81 pubmed
    ..These findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles. ..
  47. Bu D, Tomlinson G, Lewis C, Zhang C, Kildebeck E, Euhus D. An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer. Breast Cancer Res Treat. 2006;99:257-65 pubmed
    ..XRCC1 IVS10+141G>A is an intronic polymorphism that is associated with XRCC1 expression, apoptosis and familial breast cancer. It may occur within an intronic regulatory sequence. ..
  48. Epstein C, Waddle J, Hale W, Dave V, Thornton J, Macatee T, et al. Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell. 2001;12:297-308 pubmed
    ..Transcript profiling of cells harboring null alleles of RTG1, RTG2, or RTG3, genes known to control signaling from mitochondria to the nucleus, suggests that there are multiple pathways of cross-talk between these organelles in yeast. ..
  49. Lei L, Ma L, Nef S, Thai T, Parada L. mKlf7, a potential transcriptional regulator of TrkA nerve growth factor receptor expression in sensory and sympathetic neurons. Development. 2001;128:1147-58 pubmed
    ..These data are consistent with the idea that mKlf7 may directly regulate TrkA gene expression in the peripheral nervous system. ..
  50. Gillette T, Huang W, Russell S, Reed S, Johnston S, Friedberg E. The 19S complex of the proteasome regulates nucleotide excision repair in yeast. Genes Dev. 2001;15:1528-39 pubmed
    ..The 19S regulatory complex of the yeast proteasome functions in nucleotide excision repair independent of proteolysis. ..
  51. Liu B, Han Y, Ferdous A, Corey D, Kodadek T. Transcription activation by a PNA-peptide chimera in a mammalian cell extract. Chem Biol. 2003;10:909-16 pubmed
  52. Maciver I, Hansen E. Lack of expression of the global regulator OxyR in Haemophilus influenzae has a profound effect on growth phenotype. Infect Immun. 1996;64:4618-29 pubmed
    ..These results indicate that expression of a wild-type OxyR protein by H. influenzae is essential to allow this organism to protect itself against oxidative stresses in vitro...
  53. Frost J, Steen H, Shapiro P, Lewis T, Ahn N, Shaw P, et al. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 1997;16:6426-38 pubmed
    ..This demonstrates interaction among MAP kinase pathway elements not previously recognized and suggests an explanation for the cooperative effect of Raf-1 and Rho family proteins on cellular transformation. ..
  54. Archer C, Delahodde A, Gonzalez F, Johnston S, Kodadek T. Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo. J Biol Chem. 2008;283:12614-23 pubmed publisher
    ..This study validates the physiological importance of Gal4 monoubiquitylation and clarifies its major role as that of protecting the activator from being destabilized by the proteasomal ATPases. ..
  55. Shimomura I, Hammer R, Ikemoto S, Brown M, Goldstein J. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature. 1999;401:73-6 pubmed
    ..Our results support the idea that leptin modulates insulin sensitivity and glucose disposal independently of its effect on food intake, and that leptin deficiency accounts for the insulin resistance found in CGL. ..
  56. Stallings N, Hanley N, Majdic G, Zhao L, Bakke M, Parker K. Development of a transgenic green fluorescent protein lineage marker for steroidogenic factor 1. Mol Endocrinol. 2002;16:2360-70 pubmed
  57. Cheo D, Meira L, Hammer R, Burns D, Doughty A, Friedberg E. Synergistic interactions between XPC and p53 mutations in double-mutant mice: neural tube abnormalities and accelerated UV radiation-induced skin cancer. Curr Biol. 1996;6:1691-4 pubmed
    ..Additionally, we show that, following exposure to UV-B radiation, XPC p53 mutant mice have more severe solar keratosis and suffer accelerated skin cancer compared with XPC mutant mice that are wild-type with respect to p53. ..
  58. Wang L, Brown J, Cao R, Zhang Y, Kassis J, Jones R. Hierarchical recruitment of polycomb group silencing complexes. Mol Cell. 2004;14:637-46 pubmed
  59. Sato R, Yang J, Wang X, Evans M, Ho Y, Goldstein J, et al. Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J Biol Chem. 1994;269:17267-73 pubmed
    ..This study provides a picture of the domain structure of SREBP-1 and further elucidates the mechanism by which it adjusts gene transcription to maintain cholesterol homeostasis in animal cells...
  60. Zelenaya Troitskaya O, Newman S, Okamoto K, Perlman P, Butow R. Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae. Genetics. 1998;148:1763-76 pubmed
    ..These findings are discussed in the context of a model relating mtDNA copy number control and stability to mtDNA recombination. ..
  61. Hoang M, Murakata L, Katabi N, Henson D, Albores Saavedra J. Invasive papillary carcinomas of the extrahepatic bile ducts: a clinicopathologic and immunohistochemical study of 13 cases. Mod Pathol. 2002;15:1251-8 pubmed
    ..Our findings suggest that there is no correlation between p53, Ki-67, and Dpc4 expression in these tumors and survival of the patients...
  62. Hardy D, Janowski B, Corey D, Mendelson C. Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression. Mol Endocrinol. 2006;20:2724-33 pubmed
    ..Based on these findings, we propose that PR may inhibit NF-kappaB activation of COX-2 gene expression and uterine contractility via ligand-dependent and ligand-independent mechanisms. ..
  63. Shang J, Lehrman M. Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts. Biochem Biophys Res Commun. 2004;317:390-6 pubmed
  64. Yan L, Rajasekaran N, Sathyanarayanan S, Benjamin I. Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney. Antioxid Redox Signal. 2005;7:465-71 pubmed
    ..The source of mitochondrial superoxide generation is discussed. ..
  65. Iyer N, Reagan M, Wu K, Canagarajah B, Friedberg E. Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. Biochemistry. 1996;35:2157-67 pubmed
    ..Our analyses demonstrate that the XPB, XPD, p44, and p62 proteins interact with each other. XPG protein interacts with multiple subunits of TFIIH and with CSB protein. ..
  66. Guo Y, Yang M, Weissler J, Yang Y. PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia. Biochem Biophys Res Commun. 2007;360:659-65 pubmed
    ..These results further suggest that PLAGL2 is an oxidative stress responding regulator in lung cells. ..
  67. Edwards D, Towb P, Wasserman S. An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators. Development. 1997;124:3855-64 pubmed
    ..We also identify Drosophila Filamin as a potential adaptor linking the interaction network, via Tube, to the transmembrane receptor Toll. ..
  68. Holt S, Aisner D, Baur J, Tesmer V, Dy M, Ouellette M, et al. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 1999;13:817-26 pubmed
    ..To our knowledge, p23 and Hsp90 are the first telomerase-associated proteins demonstrated to contribute to telomerase activity. ..
  69. Naya F, Wu C, Richardson J, Overbeek P, Olson E. Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene. Development. 1999;126:2045-52 pubmed
    ..The discordance between MEF2 mRNA expression and MEF2 transcriptional activity in nonmuscle cell types of embryos and adults also supports the notion that post-transcriptional mechanisms regulate the expression of MEF2 proteins. ..
  70. Leon A, McKearin D. Identification of TER94, an AAA ATPase protein, as a Bam-dependent component of the Drosophila fusome. Mol Biol Cell. 1999;10:3825-34 pubmed
    ..We also show that fusome association of TER94 is Bam-dependent, suggesting that cystoblast differentiation may be linked to fusome reticulum biogenesis. ..
  71. Naya F, Black B, Wu H, Bassel Duby R, Richardson J, Hill J, et al. Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med. 2002;8:1303-9 pubmed
    ..These findings reveal specific roles for MEF2A in maintaining appropriate mitochondrial content and cyto-architectural integrity in the post-natal heart and show that other MEF2 isoforms cannot support these activities. ..
  72. Chen Z, Singer W, Wells C, Sprang S, Sternweis P. Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF. J Biol Chem. 2003;278:9912-9 pubmed
    ..This suggests that the rgRGS domain may serve a structural or allosteric role in the regulation of the nucleotide exchange activity of p115RhoGEF on Rho by Galpha(13). ..
  73. Dobrosotskaya I, Goldstein J, Brown M, Rawson R. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. J Biol Chem. 2003;278:35837-43 pubmed
    ..They indicate that insect cells can respond to sterols when proper regulatory proteins are expressed. ..
  74. Srivastava D, Gottlieb P, Olson E. Molecular mechanisms of ventricular hypoplasia. Cold Spring Harb Symp Quant Biol. 2002;67:121-5 pubmed
  75. Kuwahara K, Barrientos T, Pipes G, Li S, Olson E. Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol Cell Biol. 2005;25:3173-81 pubmed
  76. Sun L, Li L, Goldstein J, Brown M. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem. 2005;280:26483-90 pubmed publisher
    ..This hexapeptide acts as a sterol-regulated ER sorting signal. These studies define the biochemical parameters responsible for regulated sorting of an ER membrane protein into COPII-coated vesicles...
  77. Yang Y, Yang M, Guo Y, Williams O, Weissler J. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. Am J Physiol Lung Cell Mol Physiol. 2009;297:L455-66 pubmed publisher
    ..In summary, our data from both animal and human studies support a novel pathogenic role of PLAGL2 in pulmonary emphysema, a critical aspect of severe COPD. ..
  78. Ferreira P, Nakayama T, Pak W, Travis G. Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. Nature. 1996;383:637-40 pubmed
    ..The RBD4-cyclophilin supradomain of RanBP2, therefore, is a form of vertebrate chaperone of defined substrate specificity, which may be involved in the processing and/or transport of long-wavelength opsin in cone photoreceptor cells. ..
  79. Zelenski N, Rawson R, Brown M, Goldstein J. Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins. J Biol Chem. 1999;274:21973-80 pubmed
    ..The hydrophobicity of these sequences suggests that the active site of S2P is located within the membrane in an ideal position to cleave its target, a Leu-Cys bond in the first transmembrane helix of SREBPs. ..
  80. Molkentin J, Tymitz K, Richardson J, Olson E. Abnormalities of the genitourinary tract in female mice lacking GATA5. Mol Cell Biol. 2000;20:5256-60 pubmed
    ..These results reveal a specific role of GATA5 in development of the female genitourinary system and suggest that other GATA factors may have functions overlapping those of GATA5 in other tissues. ..
  81. Liang G, Yang J, Horton J, Hammer R, Goldstein J, Brown M. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem. 2002;277:9520-8 pubmed
    ..Moreover, these mRNAs, as well as multiple other lipogenic mRNAs, showed a markedly blunted response to the LXR agonist T090137, indicating an essential role of SREBP-1c in the LXR response. ..
  82. Makishima M, Lu T, Xie W, Whitfield G, Domoto H, Evans R, et al. Vitamin D receptor as an intestinal bile acid sensor. Science. 2002;296:1313-6 pubmed
    ..These studies offer a mechanism that may explain the proposed protective effects of vitamin D and its receptor against colon cancer. ..
  83. Wang D, Passier R, Liu Z, Shin C, Wang Z, Li S, et al. Regulation of cardiac growth and development by SRF and its cofactors. Cold Spring Harb Symp Quant Biol. 2002;67:97-105 pubmed
  84. Gao X, Gordon D, Zhang D, Browne R, Helms C, Gillum J, et al. CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis. Am J Hum Genet. 2007;80:957-65 pubmed
    ..Our results identify the first gene associated with IS susceptibility and suggest etiological overlap between the rare, early-onset CHARGE syndrome and common, later-onset IS. ..
  85. Tomimatsu N, Mukherjee B, Burma S. Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep. 2009;10:629-35 pubmed publisher
  86. Zhao M, Li X, Chen Z. CC2D1A, a DM14 and C2 domain protein, activates NF-kappaB through the canonical pathway. J Biol Chem. 2010;285:24372-80 pubmed publisher
    ..In addition, the deubiquitination enzyme Cylindromatosis (CYLD) negatively regulates the activity of CC2D1A. These results suggest that CC2D1A activates NF-kappaB through the canonical IKK pathway. ..
  87. Xia Y, Brown L, Yang C, Tsan J, Siciliano M, Espinosa R, et al. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci U S A. 1991;88:11416-20 pubmed
    ..Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL. ..
  88. Shimomura I, Bashmakov Y, Horton J. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem. 1999;274:30028-32 pubmed
    ..These studies suggest that increased levels of nuclear SREBP-1c contribute to the elevated rates of hepatic fatty acid synthesis that leads to steatosis in diabetic mice. ..
  89. Zhao L, Bakke M, Krimkevich Y, Cushman L, Parlow A, Camper S, et al. Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development. 2001;128:147-54 pubmed
    ..The pituitary-specific SF1 knockout mice are a novel genetic model of hypogonadotropic hypogonadism that establishes essential role(s) of SF1 in pituitary gonadotropes. ..
  90. Rutter J, Reick M, Wu L, McKnight S. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science. 2001;293:510-4 pubmed
    ..These observations raise the possibility that food, neuronal activity, or both may entrain the circadian clock by direct modulation of cellular redox state. ..
  91. Lien C, McAnally J, Richardson J, Olson E. Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev Biol. 2002;244:257-66 pubmed
  92. Phan D, Rasmussen T, Nakagawa O, McAnally J, Gottlieb P, Tucker P, et al. BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development. 2005;132:2669-78 pubmed
    ..These findings identify Bop as an essential downstream effector gene of MEF2C in the developing heart, and reveal a transcriptional cascade involved in development of the anterior heart field and its derivatives. ..