Experts and Doctors on cyclophilins in Houston, Texas, United States
Locale: Houston, Texas, United States
Kainer D, Doris P. Cyclophilin B expression in renal proximal tubules of hypertensive rats. Hypertension. 2000;35:958-64 pubmed
..In view of evidence linking CypB to the regulation of elongation initiation factor-2, the upregulation of CypB may result from metabolic stress. ..
Schneider M. Cyclophilin D: knocking on death's door. Sci STKE. 2005;2005:pe26 pubmed
..These data raise questions about the relationship between apoptotic and necrotic cell death, and they also highlight cyclophilin D as a potential therapeutic target in myocardial infarction. ..
Baldridge D, Schwarze U, Morello R, Lennington J, Bertin T, Pace J, et al
. CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta. Hum Mutat. 2008;29:1435-42 pubmed publisher
Homan E, Lietman C, Grafe I, Lennington J, Morello R, Napierala D, et al
. Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues. PLoS Genet. 2014;10:e1004121 pubmed publisher
..Our observations suggest differential tissue consequences due to selective inactivation of P3H1 hydroxylase activity versus complete ablation of the prolyl 3-hydroxylation complex. ..
Terajima M, Taga Y, Chen Y, Cabral W, Hou Fu G, Srisawasdi S, et al
. Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen. J Biol Chem. 2016;291:9501-12 pubmed publisher
..This study underscores the critical importance of collagen post-translational modifications in connective tissue formation. ..