Experts and Doctors on coup transcription factor i in Houston, Texas, United States


Locale: Houston, Texas, United States
Topic: coup transcription factor i

Top Publications

  1. Bosch D, Boonstra F, Gonzaga Jauregui C, Xu M, de Ligt J, Jhangiani S, et al. NR2F1 mutations cause optic atrophy with intellectual disability. Am J Hum Genet. 2014;94:303-9 pubmed publisher
    ..These findings indicate that NR2F1 plays an important role in the neurodevelopment of the visual system and that its disruption can lead to optic atrophy with intellectual disability. ..
  2. Qin J, Suh J, Kim B, Yu C, Tanaka T, Kodama T, et al. The expression pattern of nuclear receptors during cerebellar development. Dev Dyn. 2007;236:810-20 pubmed
    ..Taken together, our results suggest that members of the nuclear receptor superfamily might play importantly physiological roles in the cerebellum. ..
  3. Tang L, Alger H, Lin F, Pereira F. Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear. Gene Expr Patterns. 2005;5:587-92 pubmed
  4. Yamaguchi H, Zhou C, Lin S, Durand B, Tsai S, Tsai M. The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes. Dev Biol. 2004;266:238-51 pubmed
    ..Taken together, these results suggest that COUP-TFI is an important regulator of oligodendrocyte differentiation. ..
  5. Salas R, Petit F, Pipaon C, Tsai M, Tsai S. Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites. Eur J Biochem. 2002;269:317-25 pubmed
    ..In addition, COUP-TFI is coexpressed with some ETS factors in the mouse embryo. These results indicate that members of the ETS family can activate COUP-TFI gene expression. ..
  6. Wang L, Ing N, Tsai S, O Malley B, Tsai M. The COUP-TFs compose a family of functionally related transcription factors. Gene Expr. 1991;1:207-16 pubmed
    ..quot; The COUP-TF2 sequence has very strong homology with COUP-TF1. The N-termini of COUP-TF1 and COUP-TF2 are least similar, but both contain glutamine-rich and proline-rich motifs, putative activation domains. ..
  7. Qiu Y, Cooney A, Kuratani S, DeMayo F, Tsai S, Tsai M. Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Proc Natl Acad Sci U S A. 1994;91:4451-5 pubmed
    ..Our results suggest that murine COUP-TFs may play important roles in the development and differentiation of the CNS, including the specification of diencephalic neuromeres. ..
  8. Pereira F, Qiu Y, Tsai M, Tsai S. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis. J Steroid Biochem Mol Biol. 1995;53:503-8 pubmed
    ..Some of these expression domains colocalize with those of TR, RAR, and RXR. The simultaneous expression of these genes raise the possibility that COUP-TFs can act as negative regulatory factors during development and differentiation. ..
  9. Tsai S, Tsai M. Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr Rev. 1997;18:229-40 pubmed

More Information


  1. Zhou C, Tsai S, Tsai M. COUP-TFI: an intrinsic factor for early regionalization of the neocortex. Genes Dev. 2001;15:2054-9 pubmed
    ..Our results substantiate that COUP-TFI, an intrinsic factor, may work in concert with Pax6 and Emx2 to specify neocortical identity. ..
  2. Qiu Y, Krishnan V, Zeng Z, Gilbert D, Copeland N, Gibson L, et al. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. Genomics. 1995;29:240-6 pubmed
    ..Furthermore, we mapped human COUP-TF I to 5q14 of chromosome 5 and COUP-TF II to 15q26 of chromosome 15. The results demonstrate that COUP-TF genes are located in chromosomal regions that are syntenic between mouse and human. ..
  3. Wang L, Tsai S, Cook R, Beattie W, Tsai M, O Malley B. COUP transcription factor is a member of the steroid receptor superfamily. Nature. 1989;340:163-6 pubmed
    ..We conclude that this superfamily of gene regulators contains proteins which bind and activate distal promoter elements of eukaryotic genes. ..
  4. Zhou C, Qiu Y, Pereira F, Crair M, Tsai S, Tsai M. The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons. Neuron. 1999;24:847-59 pubmed
    ..These results also substantiate COUP-TFI as an important regulator of neuronal development and differentiation. ..
  5. Suh J, Yu C, Tang K, Tanaka T, Kodama T, Tsai M, et al. The expression profiles of nuclear receptors in the developing and adult kidney. Mol Endocrinol. 2006;20:3412-20 pubmed
    ..Our results suggest that these nuclear receptors are likely to play important physiological roles in the kidney development. ..
  6. Qiu Y, Pereira F, DeMayo F, Lydon J, Tsai S, Tsai M. Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev. 1997;11:1925-37 pubmed
    ..Furthermore, mCOUP-TFI possesses vital physiological functions that are distinct from mCOUP-TFII despite of their high degree of homology and extensive overlapping expression patterns. ..
  7. Tang L, Alger H, Pereira F. COUP-TFI controls Notch regulation of hair cell and support cell differentiation. Development. 2006;133:3683-93 pubmed
  8. Montemayor C, Montemayor O, Ridgeway A, Lin F, Wheeler D, Pletcher S, et al. Genome-wide analysis of binding sites and direct target genes of the orphan nuclear receptor NR2F1/COUP-TFI. PLoS ONE. 2010;5:e8910 pubmed publisher
    ..This bioinformatics tool can be modified to scan for response elements of transcription factors, cis-regulatory modules, or any flexible DNA pattern. ..
  9. Wu S, Lee D, DeMayo F, Tsai S, Tsai M. Generation of ES cells for conditional expression of nuclear receptors and coregulators in vivo. Mol Endocrinol. 2010;24:1297-304 pubmed publisher
    ..Upon completion, it will be a very valuable resource for the scientific community. Several ES cells are currently available for distribution. ..
  10. Chan S, Xu N, Niemeyer C, Bone J, Flytzanis C. SpCOUP-TF: a sea urchin member of the steroid/thyroid hormone receptor family. Proc Natl Acad Sci U S A. 1992;89:10568-72 pubmed
    ..Transcripts derived from the S. purpuratus COUP-TF homologous gene were detected in ovarian and embryonic RNAs from various stages...