Genomes and Genes
Experts and Doctors on cell line in Dallas, Texas, United States
Locale: Dallas, Texas, United States
Topic: cell line
Publications233 found, 100 shown here
- Naffin Olivos J, Auchus R. Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17. Biochemistry. 2006;45:755-62 pubmed..These data suggest that a specific allosteric binding site on b5, which includes residues E48, E49, and possibly R52, mediates the stimulation of 17,20-lyase activity. ..
- Tang J, Maximov A, Shin O, Dai H, Rizo J, Sudhof T. A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell. 2006;126:1175-87 pubmed
- Lee J, Song B, DeBose Boyd R, Ye J. Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. J Biol Chem. 2006;281:39308-15 pubmed
- Saito T, Hirai R, Loo Y, Owen D, Johnson C, Sinha S, et al. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A. 2007;104:582-7 pubmed..Modulation of RIG-I/LGP2 interaction dynamics may have therapeutic implications for immune regulation. ..
- Zhu H, Tannous P, Johnstone J, Kong Y, Shelton J, Richardson J, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007;117:1782-93 pubmed..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention. ..
- Melton A, Jackson J, Wang J, Lynch K. Combinatorial control of signal-induced exon repression by hnRNP L and PSF. Mol Cell Biol. 2007;27:6972-84 pubmed..Such a combinatorial effect on splicing allows for precise regulation of signal-induced alternative splicing. ..
- Xie D, Gore C, Liu J, Pong R, Mason R, Hao G, et al. Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A. 2010;107:2485-90 pubmed publisher..These results show the mechanism of DAB2IP in EMT and suggest that assessment of DAB2IP may provide a prognostic biomarker and potential therapeutic target for PCa metastasis. ..
- Krachler A, Ham H, Orth K. Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent. Virulence. 2012;3:68-71 pubmed publisher..Herein, we describe the use of bead-coupled MAM7 as an inhibitor of infection with the clinically relevant pathogen Pseudomonas aeruginosa. ..
- Stubbs S, Hunter O, Hoover A, Conrad N. Viral factors reveal a role for REF/Aly in nuclear RNA stability. Mol Cell Biol. 2012;32:1260-70 pubmed publisher..These studies show that REF/Aly can stabilize nuclear RNAs independently of their export and support a broader conservation of RNA quality control mechanisms from yeast to humans. ..
- Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna K, et al. Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst). 2012;11:441-8 pubmed publisher..Our results identify Exo1 as a key mediator of DNA end resection and DSB repair and damage signaling decisions in human cells. ..
- Ward S, Kim H, Komurov K, Mendiratta S, Tsai P, Schmolke M, et al. Host modulators of H1N1 cytopathogenicity. PLoS ONE. 2012;7:e39284 pubmed publisher..The observations reported here thus contribute to an expanding body of studies directed at decoding vulnerabilities in the command and control networks specified by influenza virulence factors...
- Zhang Q, Yu C, Peng S, Xu H, Wright E, Zhang X, et al. Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway. Gastroenterology. 2014;146:461-72.e6 pubmed publisher..Strategies to reduce autocrine VEGF signaling (eg, with sunitinib) might be used to prevent or treat cancer in patients with Barrett's esophagus. ..
- Li D, Wang Z, Ding G, Tan W, Luo X, Criollo A, et al. Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification. Circulation. 2016;133:1668-87 pubmed publisher..Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. Reducing autophagy initiation protects against doxorubicin cardiotoxicity. ..
- Teiber J, Billecke S, La Du B, Draganov D. Estrogen esters as substrates for human paraoxonases. Arch Biochem Biophys. 2007;461:24-9 pubmed
- Hsueh R, Natarajan M, Fraser I, Pond B, Liu J, Mumby S, et al. Deciphering signaling outcomes from a system of complex networks. Sci Signal. 2009;2:ra22 pubmed publisher..This suggests that most potential interactions are not realized and that unique cellular responses are limited to discrete subsets of ligands and pathways that enhance specific cellular functions. ..
- Heise C, Xu B, Deaton S, Cha S, Cheng C, Earnest S, et al. Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. J Biol Chem. 2010;285:25161-7 pubmed publisher..Further evidence for the importance of WNK1 in this process comes from the ability of Nedd4-2 to bind to WNK1 and the finding that endogenous SGK1 has reduced activity if WNK1 is knocked down by small interfering RNA. ..
- Kumar B, Kim Y, Demartino G. The C terminus of Rpt3, an ATPase subunit of PA700 (19 S) regulatory complex, is essential for 26 S proteasome assembly but not for activation. J Biol Chem. 2010;285:39523-35 pubmed publisher..These results provide new insights to the non-equivalent roles of Rpt subunits in 26 S proteasome function and identify specific roles for Rpt3. ..
- Motta Mena L, Smith S, Mallory M, Jackson J, Wang J, Lynch K. A disease-associated polymorphism alters splicing of the human CD45 phosphatase gene by disrupting combinatorial repression by heterogeneous nuclear ribonucleoproteins (hnRNPs). J Biol Chem. 2011;286:20043-53 pubmed publisher..Therefore, these studies provide an important example of the functional relevance of combinatorial function in splicing regulation and suggest that additional polymorphisms may similarly disrupt function of the ESS1 silencer. ..
- Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, et al. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem. 2012;287:3123-37 pubmed publisher..The nuclear fraction of lipin-1b is increased when CTDNEP1 and NEP1-R1 are co-expressed. Therefore, NEP1-R1 is functionally conserved from yeast to humans and functions in the lipin activation pathway. ..
- Huo X, Zhang X, Yu C, Zhang Q, Cheng E, Wang D, et al. In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-?B and activator protein-1. Gut. 2014;63:1042-52 pubmed publisher..These previously unrecognised PPI effects might contribute to the healing of reflux oesophagitis. ..
- Ahlgren R, Yanase T, Simpson E, Winter J, Waterman M. Compound heterozygous mutations (Arg 239----stop, Pro 342----Thr) in the CYP17 (P45017 alpha) gene lead to ambiguous external genitalia in a male patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency. J Clin Endocrinol Metab. 1992;74:667-72 pubmed..The presence of ambiguous external genitalia in this 46 XY individual indicates that greater than 20% of the total normal 17,20-lyase activity is required for complete virilization in the male. ..
- Tilley W, Marcelli M, McPhaul M. Expression of the human androgen receptor gene utilizes a common promoter in diverse human tissues and cell lines. J Biol Chem. 1990;265:13776-81 pubmed..S1 nuclease protection analyses indicate that the same promoter is employed both in human tissues (prostate, testes), in genital skin fibroblasts, in T47D and MCF-7 breast cancer cells, and in LNCaP prostate cancer cells. ..
- Hsu H, Wadman I, Baer R. Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc Natl Acad Sci U S A. 1994;91:3181-5 pubmed..Thus, the malignant properties of TAL1 may be due to obligate interaction with the E2A polypeptides. ..
- Black B, Ligon K, Zhang Y, Olson E. Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem. 1996;271:26659-63 pubmed..These results suggest that members of the MEF2 family perform similar roles in synergistic activation of transcription in myogenic and neurogenic lineages by serving as cofactors for cell type-specific bHLH proteins. ..
- Black B, Molkentin J, Olson E. Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Mol Cell Biol. 1998;18:69-77 pubmed
- Khokhlatchev A, Canagarajah B, Wilsbacher J, Robinson M, Atkinson M, Goldsmith E, et al. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell. 1998;93:605-15 pubmed..Other MAP kinase family members also form dimers. The generality of this behavior suggests that dimerization is part of the mechanism of action of the MAP kinase family. ..
- Xu B, Stippec S, Lenertz L, Lee B, Zhang W, Lee Y, et al. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem. 2004;279:7826-31 pubmed..Finally, ERK5 activation by epidermal growth factor was attenuated by suppression of WNK1 expression using small interfering RNA. Taken together, these results place WNK1 in the ERK5 MAP kinase pathway upstream of MEKK2/3. ..
- Trosky J, Mukherjee S, Burdette D, Roberts M, McCarter L, Siegel R, et al. Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus. J Biol Chem. 2004;279:51953-7 pubmed
- Takayama Y, May P, Anderson R, Herz J. Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta). J Biol Chem. 2005;280:18504-10 pubmed..Thus, LRP1 modulates PDGF signaling by controlling ubiquitination and endocytosis of the PDGFRbeta. ..
- Hormi Carver K, Feagins L, Spechler S, Souza R. All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells. Am J Physiol Gastrointest Liver Physiol. 2007;292:G18-27 pubmed..This study elucidates molecular pathways whereby retinoid treatment might prevent carcinogenesis in Barrett's metaplasia and suggests a potential role for the use of safer retinoids for chemoprevention in Barrett's esophagus. ..
- Zhao M, Li X, Chen Z. CC2D1A, a DM14 and C2 domain protein, activates NF-kappaB through the canonical pathway. J Biol Chem. 2010;285:24372-80 pubmed publisher..In addition, the deubiquitination enzyme Cylindromatosis (CYLD) negatively regulates the activity of CC2D1A. These results suggest that CC2D1A activates NF-kappaB through the canonical IKK pathway. ..
- Shang L, Chen S, Du F, Li S, Zhao L, Wang X. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A. 2011;108:4788-93 pubmed publisher..This study therefore revealed previously unnoticed acute autophagy response to environmental changes. ..
- Schulz S, Chrisman T, Garbers D. Cloning and expression of guanylin. Its existence in various mammalian tissues. J Biol Chem. 1992;267:16019-21 pubmed..Therefore, the ligand and apparent receptor (guanylyl cyclase C) both originate from mammalian genes, and are expressed in various mammalian tissues. ..
- Cali J, Hsieh C, Francke U, Russell D. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J Biol Chem. 1991;266:7779-83 pubmed..These findings underscore the essential role played by sterols in the central nervous system and suggest that mutations in other sterol metabolizing enzymes may contribute to diseases with neurological manifestations. ..
- Li C, Ullrich B, Zhang J, Anderson R, Brose N, Sudhof T. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Nature. 1995;375:594-9 pubmed..The same C2 domains also bind syntaxin as a function of Ca2+ but the Ca(2+)-concentration dependence of Syt I, II and V (> 200 microM) differs from that of Syt III and VII (< 10 microM).(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Mohamadzadeh M, Ariizumi K, Sugamura K, Bergstresser P, Takashima A. Expression of the common cytokine receptor gamma chain by murine dendritic cells including epidermal Langerhans cells. Eur J Immunol. 1996;26:156-60 pubmed..e. gamma c receptors) are expressed on XS52 cell surfaces. We thus conclude that DC express functional gamma c receptors, which then mediate cytokine-dependent regulation of DC functions. ..
- Stepp S, Dufourcq Lagelouse R, Le Deist F, Bhawan S, Certain S, Mathew P, et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science. 1999;286:1957-9 pubmed..Thus, defects in perforin are responsible for 10q21-22-linked FHL. Perforin-based effector systems are, therefore, involved not only in the lysis of abnormal cells but also in the down-regulation of cellular immune activation. ..
- Prueitt R, Ross J, Zinn A. Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. Cytogenet Cell Genet. 2000;89:44-50 pubmed..Although the physiologic substrates for the enzyme are not known, XPNPEP2 is a candidate gene for POF. Our breakpoint mapping data will help to identify additional candidate POF genes and to delineate the Xq POF critical region(s). ..
- Nakagawa O, McFadden D, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, et al. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A. 2000;97:13655-60 pubmed..These findings identify HRT genes as downstream targets for Notch signaling and reveal a negative autoregulatory loop whereby HRT proteins repress their own expression through interference with Notch signaling. ..
- Cowan C, Henkemeyer M. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature. 2001;413:174-9 pubmed..These data provide a biochemical pathway whereby cytoskeletal regulators are recruited to Eph-ephrin bidirectional signalling complexes. ..
- Matsue H, Matsue K, Kusuhara M, Kumamoto T, Okumura K, Yagita H, et al. Immunosuppressive properties of CD95L-transduced "killer" hybrids created by fusing donor- and recipient-derived dendritic cells. Blood. 2001;98:3465-72 pubmed
- Lee S, Shah S, Yu C, Wigley W, Li H, Lim M, et al. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex. J Biol Chem. 2004;279:4144-52 pubmed..These findings suggest that APH-1 plays a GXXXG-dependent scaffolding role in both the initial assembly and subsequent maturation and maintenance of the active gamma-secretase complex. ..
- Geng W, Wang Z, Zhang J, Reed B, Pak C, Moe O. Cloning and characterization of the human soluble adenylyl cyclase. Am J Physiol Cell Physiol. 2005;288:C1305-16 pubmed..In summary, hsAC is a divalent cation and HCO(3)(-) sensor, and its HCO(3)(-) sensitivity is modulated by divalent cations. ..
- Arai S, Shelton J, Chen M, Bradley M, Castrillo A, Bookout A, et al. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab. 2005;1:201-13 pubmed..We conclude that AIM production facilitates macrophage survival within atherosclerotic lesions and that loss of AIM decreases early lesion development by increasing macrophage apoptosis. ..
- Pearson M, Laurence C, Guinn S, Hansen E. Biofilm formation by Moraxella catarrhalis in vitro: roles of the UspA1 adhesin and the Hag hemagglutinin. Infect Immun. 2006;74:1588-96 pubmed..The Hag protein was shown to have an inhibitory or negative effect on biofilm formation by these M. catarrhalis strains in the crystal violet-based assay. ..
- Tyler D, Persky M, Matthews L, Chan S, Farrar J. Pre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain. Mol Immunol. 2007;44:1864-72 pubmed..Thus, the human IFNAR2 cytoplasmic domain serves to link STAT4 to the IFNAR as a pre-assembled complex that facilitates cytokine-driven STAT4 activation. ..
- Nunbhakdi Craig V, Schuechner S, Sontag J, Montgomery L, Pallas D, Juno C, et al. Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules. J Neurochem. 2007;101:959-71 pubmed..They support the hypothesis that reduced amounts of neuronal B alpha-containing PP2A heterotrimers contribute to MT destabilization in Alzheimer's disease. ..
- Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt K, Goetz R, et al. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A. 2007;104:7432-7 pubmed..Importantly, administration of FGF21 into mice induces MAP kinase phosphorylation in white adipose tissue and not in tissues without betaKlotho expression. Thus, betaKlotho functions as a cofactor essential for FGF21 activity. ..
- Trosky J, Li Y, Mukherjee S, Keitany G, Ball H, Orth K. VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases. J Biol Chem. 2007;282:34299-305 pubmed..Identifying the target of VopA reveals a way that the reversible post-translational modification of lysine acetylation can be used to regulate the activity of an enzyme. ..
- Tomihari M, Hwang S, Chung J, Cruz P, Ariizumi K. Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion. Exp Dermatol. 2009;18:586-95 pubmed publisher..PAM212 keratinocytes adhered to immobilized Gpnmb in a RGD-dependent manner. These results indicate that Gpnmb is a melanosome-associated glycoprotein that contributes to the adhesion of melanocytes with keratinocytes. ..
- Barylko B, Wang L, Binns D, Ross J, Tassin T, Collins K, et al. The proline/arginine-rich domain is a major determinant of dynamin self-activation. Biochemistry. 2010;49:10592-4 pubmed publisher..Dynamin proline/arginine-rich domains also mediate interactions with SH3 domain-containing proteins and thus regulate both self-association and heteroassociation of dynamins. ..
- Hou F, Sun L, Zheng H, Skaug B, Jiang Q, Chen Z. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell. 2011;146:448-61 pubmed publisher..These results suggest that a prion-like conformational switch of MAVS activates and propagates the antiviral signaling cascade. ..
- Jin Z, Wei W, Dechow P, Wan Y. HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered ?-catenin switch. Mol Endocrinol. 2013;27:325-35 pubmed publisher..003) owing to 102% elevated bone resorption (P = 0.01). These findings are clinically significant in light of the remarkable therapeutic potentials of HDAC inhibitors for several diseases such as cancer, diabetes, and neurodegeneration. ..
- Barth C, Humphries E. Expression of v-rel induces mature B-cell lines that reflect the diversity of avian immunoglobulin heavy- and light-chain rearrangements. Mol Cell Biol. 1988;8:5358-68 pubmed..The development of these and similar cell lines will make it possible to identify specific stages of avian lymphoid ontogeny and to study the mechanism of rearrangement and diversification in the avian B lymphocyte. ..
- Dessauer C, Gilman A. Purification and characterization of a soluble form of mammalian adenylyl cyclase. J Biol Chem. 1996;271:16967-74 pubmed..After adenovirus-mediated expression in adenylyl cyclase-deficient HC-1 cells, the enzyme can be stimulated synergistically by Gs-coupled receptors and forskolin. ..
- Ye J, Rawson R, Komuro R, Chen X, Dav U, Prywes R, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000;6:1355-64 pubmed..ATF6 processing did not require SCAP, which is essential for SREBP processing. We conclude that S1P and S2P are required for the ER stress response as well as for lipid synthesis...
- Yamamoto M, Hilgemann D, Feng S, Bito H, Ishihara H, Shibasaki Y, et al. Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells. J Cell Biol. 2001;152:867-76 pubmed
- Chen Z, Cobb M. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. J Biol Chem. 2001;276:16070-5 pubmed..Activation of endogenous TAO2 during differentiation of C2C12 myoblasts paralleled activation of p38 but not JNK/SAPK, consistent with the idea that TAO2 is a physiological regulator of p38 under certain circumstances. ..
- Wang C, Deng L, Hong M, Akkaraju G, Inoue J, Chen Z. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. 2001;412:346-51 pubmed..We also provide evidence that TRAF6 is conjugated by the K63 polyubiquitin chains. These results indicate that ubiquitination has an important regulatory role in stress response pathways, including those of IKK and JNK. ..
- Berman K, McKay J, Avery L, Cobb M. Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Mol Cell Biol Res Commun. 2001;4:337-44 pubmed..PMK-1 and PMK-2 phosphorylated activating transcription factor-2 (ATF-2), indicating an activity similar to mammalian p38. When transfected into mammalian cells, these kinases, like p38, are stimulated by osmotic stresses. ..
- Radyuk S, Sohal R, Orr W. Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells. Biochem J. 2003;371:743-52 pubmed..Manipulations in the levels of TPxs demonstrated that, under different stress conditions, these enzymes might have both beneficial and detrimental effects on Drosophila cell viability. ..
- Shin O, Han W, Wang Y, Sudhof T. Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. J Biol Chem. 2005;280:1641-51 pubmed
- Kuwahara K, Barrientos T, Pipes G, Li S, Olson E. Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol Cell Biol. 2005;25:3173-81 pubmed
- Pipes G, Sinha S, Qi X, Zhu C, Gallardo T, Shelton J, et al. Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression. Dev Biol. 2005;288:502-13 pubmed
- Soyombo A, Tjon Kon Sang S, Rbaibi Y, Bashllari E, Bisceglia J, Muallem S, et al. TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem. 2006;281:7294-301 pubmed..Furthermore, dissipation of the acidic lysosomal pH of TRP-ML1(-/-) cells by nigericin or chloroquine reversed the lysosomal storage disease phenotype. These findings provide a new mechanism to account for the pathogenesis of MLIV. ..
- Min S, Chang W, Sudhof T. E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Proc Natl Acad Sci U S A. 2007;104:3823-8 pubmed
- Kuwahara K, Teg Pipes G, McAnally J, Richardson J, Hill J, Bassel Duby R, et al. Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity. J Clin Invest. 2007;117:1324-34 pubmed..These findings suggest that STARS modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between MEF2 and SRF. ..
- Radyuk S, Michalak K, Klichko V, Benes J, Rebrin I, Sohal R, et al. Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila. Biochem J. 2009;419:437-45 pubmed publisher..Results from the present study suggest that the antioxidant and anti-apoptotic activities of dPrx5 play a critical role in development and aging of the fly. ..
- Hu J, Dodd D, Hudson R, Corey D. Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine. Bioorg Med Chem Lett. 2009;19:6181-4 pubmed publisher..We observe elevated melting temperatures, localization to cellular compartments, and allele-selective inhibition of mutant huntingtin protein expression. ..
- Kim H, Yamaguchi S, Li Q, So I, Muallem S. Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation. J Biol Chem. 2010;285:16513-20 pubmed publisher..These findings describe a novel mode of a transient receptor potential channel behavior and suggest that pore expansion by the A419P mutation may contribute to the varitint-waddler phenotype. ..
- Selyunin A, Sutton S, Weigele B, Reddick L, Orchard R, Bresson S, et al. The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold. Nature. 2011;469:107-11 pubmed publisher..Unexpectedly, ARF and PAKs are organized on adjacent surfaces of EspG, indicating its role as a 'catalytic scaffold' that effectively reprograms cellular events through the functional assembly of GTPase-kinase signalling complex. ..
- Chen C, Hardy D, Mendelson C. Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/DUSP1). J Biol Chem. 2011;286:43091-102 pubmed publisher..Collectively, these findings suggest that MKP-1 is a critical mediator of anti-proliferative and anti-inflammatory actions of PR in the breast. ..
- Mundy D, Li W, Luby Phelps K, Anderson R. Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content. Mol Biol Cell. 2012;23:864-80 pubmed publisher..We conclude that caveolin-1 normally traffics to and from the cytoplasmic surface of lysosomes during intracellular cholesterol trafficking. ..
- Frederick G, Amirkhan R, Schultz R, Friedberg E. Structural and mutational analysis of the xeroderma pigmentosum group D (XPD) gene. Hum Mol Genet. 1994;3:1783-8 pubmed..These results confirm the role of ERCC2 in XP-D and illustrate the power of utilizing cellular phenotypes to evaluate the significance of single nucleotide substitutions. ..
- Hinshelwood M, Corbin C, Tsang P, Simpson E. Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450. Endocrinology. 1993;133:1971-7 pubmed
- Kasus Jacobi A, Ou J, Bashmakov Y, Shelton J, Richardson J, Goldstein J, et al. Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem. 2003;278:32380-9 pubmed
- Sato M, Girard L, Sekine I, Sunaga N, Ramirez R, Kamibayashi C, et al. Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer. Oncogene. 2003;22:7243-6 pubmed..Our results suggest that alterations of FEN1 are not likely to contribute to development of lung cancer. ..
- Ea C, Deng L, Xia Z, Pineda G, Chen Z. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell. 2006;22:245-57 pubmed..These results reveal the biochemical mechanism underlying the essential signaling function of NEMO and provide direct evidence that signal-induced site-specific ubiquitination of RIP1 is required for IKK activation. ..
- Fuster D, Bobulescu I, Zhang J, Wade J, Moe O. Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin. Am J Physiol Renal Physiol. 2007;292:F577-85 pubmed..In summary, insulin stimulates NHE3 acutely via yet undefined pathways and mechanisms. The chronic effect of insulin is mediated by the classic PI3K-SGK1 route. ..
- Chakraborty P, Seemann J, Mishra R, Wei J, Weil L, Nussenzveig D, et al. Vesicular stomatitis virus inhibits mitotic progression and triggers cell death. EMBO Rep. 2009;10:1154-60 pubmed publisher..VSV is an oncolytic (anti-tumour) agent as it preferentially replicates and kills tumour cells. As tumour cells have a high mitotic index, VSV-mediated mitotic cell death probably contributes to its oncolytic activity. ..
- Boulton T, Gregory J, Jong S, Wang L, Ellis L, Cobb M. Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid. J Biol Chem. 1990;265:2713-9 pubmed..L. (1988) Nature 334, 715-718). We find that the IRros receptor stimulates the MAP2 protein kinase from 3- to 6-fold in insulin-treated cells, conferring more than a 30-fold increase in the insulin sensitivity of MAP2 kinase activation. ..
- Fernandez Vina M, Lazaro A, Sun Y, Miller S, Forero L, Stastny P. Population diversity of B-locus alleles observed by high-resolution DNA typing. Tissue Antigens. 1995;45:153-68 pubmed..It should also be valuable for population studies and for the investigation of HLA associations with diseases. ..
- Makishima M, Okamoto A, Repa J, Tu H, Learned R, Luk A, et al. Identification of a nuclear receptor for bile acids. Science. 1999;284:1362-5 pubmed..These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport. ..
- Gale M, Blakely C, Darveau A, Romano P, Korth M, Katze M. P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress. Biochemistry. 2002;41:11878-87 pubmed