Genomes and Genes
Experts and Doctors on bacterial proteins in Houston, Texas, United States
Locale: Houston, Texas, United States
Topic: bacterial proteins
Publications272 found, 100 shown here
- Davlieva M, Zhang W, Arias C, Shamoo Y. Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci. Antimicrob Agents Chemother. 2013;57:289-96 pubmed publisher..As mutations to Cls are part of a larger genomic adaptation process, increased Cls activity is likely to be highly epistatic with other changes to facilitate DAP resistance. ..
- Lee C, Kohara Y, Akiyama K, Smith C, Craigen W, Caskey C. Rapid and precise mapping of the Escherichia coli release factor genes by two physical approaches. J Bacteriol. 1988;170:4537-41 pubmed..The RF2 gene is located at 62.3 min on the chromosome, while the RF1 gene is located at 26.7 min. This approach to mapping cloned genes promises to be a rapid and simple means for determining the gene order of the genome. ..
- Lee L, Hook M, Haviland D, Wetsel R, Yonter E, Syribeys P, et al. Inhibition of complement activation by a secreted Staphylococcus aureus protein. J Infect Dis. 2004;190:571-9 pubmed..These data suggest that Efb is a virulence factor involved in facilitating persistent S. aureus infections by interfering with complement activity in vivo. ..
- Zhang W, Olson J, Phillips G. Biophysical and kinetic characterization of HemAT, an aerotaxis receptor from Bacillus subtilis. Biophys J. 2005;88:2801-14 pubmed..The unusual ligand-binding properties of HemAT suggest that asymmetry and apparent negative cooperativity play an important role in the signal transduction pathway. ..
- Martin S, Mu X, Klein W. Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2. Differentiation. 2005;73:18-27 pubmed..The results demonstrate that Brn3b regulates gene expression through the action of a strong transcriptional activation domain within its N-terminal sequence. ..
- Li X, Chow D, Tu S. Thermodynamic analysis of the binding of oxidized and reduced FMN cofactor to Vibrio harveyi NADPH-FMN oxidoreductase FRP apoenzyme. Biochemistry. 2006;45:14781-7 pubmed publisher..These findings are also discussed in relation to the function of FRP as a reduced flavin donor in the FRP-luciferase couple...
- Arias C, Torres H, Singh K, Panesso D, Moore J, Wanger A, et al. Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster. Clin Infect Dis. 2007;45:1343-6 pubmed..The infecting organism exhibited in vivo emergence of a vancomycin-susceptible subpopulation lacking vanA. Treatment with a combination of high-dose daptomycin, gentamicin, and high-dose ampicillin cleared the infection. ..
- Li M, Chen W, Poungvarin N, Imamura M, Chan L. Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3. Mol Endocrinol. 2008;22:1658-72 pubmed publisher..We conclude that individual subdomains in the GSM (MCR I through V) play diverse but crucial roles in cooperation with essential trans-acting cofactors such as 14-3-3 proteins to mediate the glucose response of ChREBP. ..
- Chu C, Stewart P, Bestor A, Hansen B, Lin T, Gao L, et al. Function of the Borrelia burgdorferi FtsH Homolog Is Essential for Viability both In Vitro and In Vivo and Independent of HflK/C. MBio. 2016;7:e00404-16 pubmed publisher..burgdorferi physiology. Our results provide the groundwork for the identification of FtsH substrates that are critical for the bacterium's viability. ..
- Duan X, Hall J, Nikaido H, Quiocho F. Crystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding. J Mol Biol. 2001;306:1115-26 pubmed..This versatility reflects the flexibility of the protein, from very large motions of interdomain rotation to more localized side-chain conformational changes, and adaptation by the oligosaccharides as well...
- Sineshchekov O, Spudich E, Trivedi V, Spudich J. Role of the cytoplasmic domain in Anabaena sensory rhodopsin photocycling: vectoriality of Schiff base deprotonation. Biophys J. 2006;91:4519-27 pubmed
- Igoshin O, Alves R, Savageau M. Hysteretic and graded responses in bacterial two-component signal transduction. Mol Microbiol. 2008;68:1196-215 pubmed publisher..The implications of this potential bistability in the design of the EnvZ/OmpR network and other TCS are discussed. ..
- Bourgogne A, Garsin D, Qin X, Singh K, Sillanpaa J, Yerrapragada S, et al. Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF. Genome Biol. 2008;9:R110 pubmed publisher..Additionally, OG1RF's effects in experimental models suggest that mediators of virulence may be diverse between different E. faecalis strains and that virulence is not dependent on the presence of mobile genetic elements. ..
- Eraso J, Kaplan S. Regulation of gene expression by PrrA in Rhodobacter sphaeroides 2.4.1: role of polyamines and DNA topology. J Bacteriol. 2009;191:4341-52 pubmed publisher..We propose that polyamines and DNA supercoiling act synergistically to regulate expression of the RSP3361 gene, partly by affecting the affinity of PrrA binding to the PrrA site 2 within the RSP3361 gene...
- Singh K, Lewis R, Murray B. Importance of the epa locus of Enterococcus faecalis OG1RF in a mouse model of ascending urinary tract infection. J Infect Dis. 2009;200:417-20 pubmed publisher..001) and bladder (P < .001). In conclusion, the epa locus of E. faecalis OG1RF contributes to murine urinary tract infection and is the first such enterococcal polysaccharide locus shown to be important in this site...
- Jiang Z, Ke S, DuPont H. Rifaximin-induced alteration of virulence of diarrhoea-producing Escherichia coli and Shigella sonnei. Int J Antimicrob Agents. 2010;35:278-81 pubmed publisher..At subinhibitory concentrations, rifaximin alters the virulence of ETEC, EAEC and S. sonnei isolates. These findings help explain the efficacy of rifaximin despite minimal alteration of colonic flora. ..
- Brown N, Palzkill T. Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display. Protein Eng Des Sel. 2010;23:469-78 pubmed publisher..The phage system, as well as enzyme inhibition assays with purified proteins, revealed that BLIP-II is a more potent inhibitor than BLIP for several class A beta-lactamases with K(i) values in the low picomolar range. ..
- Nguyen P, Silberg J. A selection that reports on protein-protein interactions within a thermophilic bacterium. Protein Eng Des Sel. 2010;23:529-36 pubmed publisher..This selection increases the maximum temperature where a PCA can be used to engineer thermostable protein complexes and to map protein-protein interactions...
- Stagg L, Christiansen A, Wittung Stafshede P. Macromolecular crowding tunes folding landscape of parallel ?/? protein, apoflavodoxin. J Am Chem Soc. 2011;133:646-8 pubmed publisher..We propose that conditions more closely mimicking the cellular environment make the ensemble of unfolded conformations less expanded, resulting in a folding funnel that is smoother and narrower...
- Liu J, Hu B, Morado D, Jani S, Manson M, Margolin W. Molecular architecture of chemoreceptor arrays revealed by cryoelectron tomography of Escherichia coli minicells. Proc Natl Acad Sci U S A. 2012;109:E1481-8 pubmed publisher..This architecture provides a structural basis for array formation and could explain the high sensitivity and cooperativity of chemotaxis signaling in E. coli. ..
- Zheng Z, Chang E. A bimolecular fluorescent complementation screen reveals complex roles of endosomes in Ras-mediated signaling. Methods Enzymol. 2014;535:25-38 pubmed publisher..Here, we describe how BiFC can be used to detect and screen for Ras effectors and for readily revealing where in the cell the binding occurs. ..
- Jousselin A, Manzano C, Biette A, Reed P, Pinho M, Rosato A, et al. The Staphylococcus aureus Chaperone PrsA Is a New Auxiliary Factor of Oxacillin Resistance Affecting Penicillin-Binding Protein 2A. Antimicrob Agents Chemother. 2015;60:1656-66 pubmed publisher..This additional level of control in the expression of the mecA-dependent MRSA phenotype constitutes an opportunity to expand the strategies to design anti-infective agents. ..
- Tsui H, Mandavilli B, Winkler M. Nonconserved segment of the MutL protein from Escherichia coli K-12 and Salmonella typhimurium. Nucleic Acids Res. 1992;20:2379 pubmed
- Frazier Bowers S, Scott M, Cavender A, Mensah J, D Souza R. Mutational analysis of families affected with molar oligodontia. Connect Tissue Res. 2002;43:296-300 pubmed..Pedigree analysis revealed that the oligodontia trait is inherited in an autosomal dominant fashion. Mutational analysis of PAX9 thus far excludes the presence of the previously identified frameshift mutation. ..
- Atmakuri K, Ding Z, Christie P. VirE2, a type IV secretion substrate, interacts with the VirD4 transfer protein at cell poles of Agrobacterium tumefaciens. Mol Microbiol. 2003;49:1699-713 pubmed..Together, our findings establish for the first time that a protein substrate of a type IV secretion system is recruited to a member of the coupling protein superfamily...
- Couch R, O Connor S, Seidle H, Walsh C, Parry R. Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine. J Bacteriol. 2004;186:35-42 pubmed..The availability of catalytically active CmaA should facilitate elucidation of the details of the subsequent steps in the formation of this novel cyclopropyl amino acid...
- Lu H, Hsu P, Graham D, Yamaoka Y. Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology. 2005;128:833-48 pubmed..Its association with DU-promoting and -protective effects against atrophy/cancer was evident in both Asian and Western countries. ..
- Singh C, Moulton R, Armitige L, Bidani A, Snuggs M, Dhandayuthapani S, et al. Processing and presentation of a mycobacterial antigen 85B epitope by murine macrophages is dependent on the phagosomal acquisition of vacuolar proton ATPase and in situ activation of cathepsin D. J Immunol. 2006;177:3250-9 pubmed..Because Ag85B is immunodominant, this state may lead to a decreased ability of the wild-type as well as the BCG vaccine to induce protective immunity. ..
- Wong M, Wu S, Causey T, Bennett G, San K. Reduction of acetate accumulation in Escherichia coli cultures for increased recombinant protein production. Metab Eng. 2008;10:97-108 pubmed publisher..In summary, the ptsHI mutant of GJT001 resulted in reduced acetate accumulation, which led to significant improvements in recombinant protein production in batch bioreactors. ..
- Garg R, Parry R. Regulation of valanimycin biosynthesis in Streptomyces viridifaciens: characterization of VlmI as a Streptomyces antibiotic regulatory protein (SARP). Microbiology. 2010;156:472-83 pubmed publisher..Introduction of the same vlmI expression plasmid into an S. viridifaciens vlmI mutant restored valanimycin production to wild-type levels. ..
- Tabassam F, Graham D, Yamaoka Y. Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling. Am J Physiol Gastrointest Liver Physiol. 2011;301:G601-11 pubmed publisher..pylori-induced EGFR, FAK/Src, and PI3K/Akt signaling to regulate cytoskeletal reorganization and IL-8 production in part, thus contributing to the H. pylori-induced diseases. ..
- Eswaramoorthy P, Dravis A, Devi S, Vishnoi M, Dao H, Fujita M. Expression level of a chimeric kinase governs entry into sporulation in Bacillus subtilis. J Bacteriol. 2011;193:6113-22 pubmed publisher..Taken together with our previous observations, we propose that the primary role of the N-terminal domain of KinA is to form a functional tetramer, but not for sensing an unknown signal. ..
- Meng S, Bennett G. Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH. J Bacteriol. 1992;174:2659-69 pubmed
- Scotcher M, Bennett G. SpoIIE regulates sporulation but does not directly affect solventogenesis in Clostridium acetobutylicum ATCC 824. J Bacteriol. 2005;187:1930-6 pubmed publisher..These results suggest that SpoIIE has no direct effect on the control of solventogenesis and that the changes in solvent production in spoIIE-downregulated cells are mediated by effects on the cell during sporulation...
- Bonnefoy V, DeMoss J. Identification of functional cis-acting sequences involved in regulation of narK gene expression in Escherichia coli. Mol Microbiol. 1992;6:3595-602 pubmed..In the absence of the NarL2 box, the NarL1 box did not promote stimulation by nitrate. The Fnr2 box was not required for anaerobic induction of expression but its modification appeared to reduce the level of stimulation by nitrate. ..
- Parry R, Li W. Purification and characterization of isobutylamine N-hydroxylase from the valanimycin producer Streptomyces viridifaciens MG456-hF10. Arch Biochem Biophys. 1997;339:47-54 pubmed..The pI of the protein was found to be ca. 5.1 and the enzyme exhibited a sensitivity to thiol-directed reagents. ..
- Oh J, Ko I, Kaplan S. Digging deeper: uncovering genetic loci which modulate photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1. Microbiology. 2003;149:949-60 pubmed
- Schumacher M, Seidel G, Hillen W, Brennan R. Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. J Biol Chem. 2006;281:6793-800 pubmed..This latter finding demonstrates that this contact region is necessary and sufficient to throw the allosteric switch to activate cre binding by CcpA. ..
- Magner D, Blankschien M, Lee J, Pennington J, Lupski J, Rosenberg S. RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins. Mol Cell. 2007;26:273-86 pubmed..The data imply that RecQ promotes the net accumulation of BRIs in vivo, indicating a second paradigm for the in vivo effect of RecQ-like proteins. The E. coli RecQ paradigm may provide a useful model for some human RecQ homologs. ..
- Septimus E, Kuper K. Clinical challenges in addressing resistance to antimicrobial drugs in the twenty-first century. Clin Pharmacol Ther. 2009;86:336-9 pubmed publisher..The situation is even more alarming with respect to gram-negative pathogens, especially because there are currently no late clinical trials involving new anti-infective drugs that are active against these pathogens. ..
- Xia Y, Yamaoka Y, Zhu Q, Matha I, Gao X. A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori. PLoS ONE. 2009;4:e7736 pubmed publisher..Our results shed light on the relationships between the types of CagAs, the country of origin of each sequence type, and the frequency of gastric disease. ..
- Brooks B, Piro K, Brennan R. Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions. J Am Chem Soc. 2007;129:8389-95 pubmed..Chemical redundancy is likely a hallmark of all multidrug-binding pockets, yet it is utilized by only a subset of drugs, which, for QacR, so far appears to be limited to chemically rigid, bivalent compounds. ..
- Ma X, Ehrhardt D, Margolin W. Colocalization of cell division proteins FtsZ and FtsA to cytoskeletal structures in living Escherichia coli cells by using green fluorescent protein. Proc Natl Acad Sci U S A. 1996;93:12998-3003 pubmed..coli FtsZ, suggesting a degree of interspecies functional conservation. Analysis of several deletions of FtsA-GFP suggests that multiple segments of FtsA are important for its localization to the FtsZ ring. ..
- Shiomi D. [Mechanism underlying subcellular localization of proteins in Escherichia coli]. Seikagaku. 2008;80:36-40 pubmed
- Sugimoto M, Yamaoka Y. The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations. Clin Microbiol Infect. 2009;15:835-42 pubmed publisher..Further studies will be required to evaluate the effects of vacA genotypes in African populations because of the small sample number currently available. ..
- Arias C, Murray B. The rise of the Enterococcus: beyond vancomycin resistance. Nat Rev Microbiol. 2012;10:266-78 pubmed publisher..Finally, we review the most important mechanisms of resistance to the antibiotics that are used to treat vancomycin-resistant enterococci...
- Klysik J. Both an altered DNA structure and cellular proteins are involved in protecting a triplex forming an oligopurine-rich sequence from Dam methylation in E. coli. Biochem Genet. 1996;34:165-78 pubmed..Therefore it is likely that the combination of altered DNA conformation and a cellular protein leads to Dam-site protection. We also found that the site-specific undermethylation is detectable in certain E. coli strains only. ..
- Ma Y, Patel J, Parry R. A novel valanimycin-resistance determinant (vlmF) from Streptomyces viridifaciens MG456-hF10. Microbiology. 2000;146 ( Pt 2):345-52 pubmed
- Honsa E, Maresso A. Mechanisms of iron import in anthrax. Biometals. 2011;24:533-45 pubmed publisher..anthracis iron acquisition and applies these findings to a general understanding of how pathogenic Gram-positive bacteria transport this critical nutrient during infection. ..
- Heidrich N, Bauriedl S, Barquist L, Li L, Schoen C, Vogel J. The primary transcriptome of Neisseria meningitidis and its interaction with the RNA chaperone Hfq. Nucleic Acids Res. 2017;45:6147-6167 pubmed publisher..Our genome-wide RNA compendium will allow for a better understanding of meningococcal transcriptome organization and riboregulation with implications for colonization of the human nasopharynx. ..
- Singh K, Nallapareddy S, Sillanpaa J, Murray B. Importance of the collagen adhesin ace in pathogenesis and protection against Enterococcus faecalis experimental endocarditis. PLoS Pathog. 2010;6:e1000716 pubmed publisher..0001) and showed fewer CFU in vegetations (P = 0.0146). In conclusion, we have shown for the first time that Ace is involved in pathogenesis of, and is useful for protection against, E. faecalis experimental endocarditis. ..
- Koehler T. Bacillus anthracis physiology and genetics. Mol Aspects Med. 2009;30:386-96 pubmed publisher..cereus group. The developmental nature of B. anthracis and its pathogenic (mammalian host) and environmental (soil) lifestyles of make it an interesting model for study of niche-specific bacterial gene expression and physiology. ..
- Vieyra D, Goodell M. Pluripotentiality and conditional transgene regulation in human embryonic stem cells expressing insulated tetracycline-ON transactivator. Stem Cells. 2007;25:2559-66 pubmed..Disclosure of potential conflicts of interest is found at the end of this article. ..
- Sillanpaa J, Prakash V, Nallapareddy S, Murray B. Distribution of genes encoding MSCRAMMs and Pili in clinical and natural populations of Enterococcus faecium. J Clin Microbiol. 2009;47:896-901 pubmed publisher..The strong association of these genes with clinical isolates raises the possibility that their preservation/acquisition has favored the adaptation of E. faecium to nosocomial environments and/or patients. ..
- Corbin B, Yu X, Margolin W. Exploring intracellular space: function of the Min system in round-shaped Escherichia coli. EMBO J. 2002;21:1998-2008 pubmed publisher..A new model for the spatial control of division planes by the Min system in round cells is proposed...
- Sun Q, Margolin W. Effects of perturbing nucleoid structure on nucleoid occlusion-mediated toporegulation of FtsZ ring assembly. J Bacteriol. 2004;186:3951-9 pubmed..Although indirect effects are certainly possible with these experiments, the above data suggest that optimum NO activity may require specific organization and structure of the nucleoid. ..
- Yao N, Trakhanov S, Quiocho F. Refined 1.89-A structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins. Biochemistry. 1994;33:4769-79 pubmed..These structures provide understanding of molecular recognition of a variety of ligands at the atomic level and functional roles of the binding proteins. ..
- Hu B, Lara Tejero M, Kong Q, Galan J, Liu J. In Situ Molecular Architecture of the Salmonella Type III Secretion Machine. Cell. 2017;168:1065-1074.e10 pubmed publisher..These studies provide major insight into the structure and assembly of a broadly distributed protein secretion machine. ..
- Xu H, Moraitis M, Reedstrom R, Matthews K. Kinetic and thermodynamic studies of purine repressor binding to corepressor and operator DNA. J Biol Chem. 1998;273:8958-64 pubmed..The distinct metabolic roles of the enzymes under regulation by these two repressor proteins provide a rationale for the observed functional differences. ..
- Graham D, Yamaoka Y. H. pylori and cagA: relationships with gastric cancer, duodenal ulcer, and reflux esophagitis and its complications. Helicobacter. 1998;3:145-51 pubmed
- Teng F, Wang L, Singh K, Murray B, Weinstock G. Involvement of PhoP-PhoS homologs in Enterococcus faecalis virulence. Infect Immun. 2002;70:1991-6 pubmed..In conclusion, many potential two-component systems are identified for E. faecalis, one of which, EtaRS, was shown to be involved in stress response and virulence...
- Quiocho F, Spurlino J, Rodseth L. Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor. Structure. 1997;5:997-1015 pubmed
- Belouski E, Watson D, Bennett G. Cloning, sequence, and expression of the phosphofructokinase gene of Clostridium acetobutylicum ATCC 824 in Escherichia coli. Curr Microbiol. 1998;37:17-22 pubmed..Such an arrangement for the genes encoding key regulators of glycolytic flux had not yet been described in a strict anaerobe. This gene arrangement has been found in other Gram-positive organisms, but not in Gram-negative organisms...
- Zhao J, Leung H, Winkler M. The miaA mutator phenotype of Escherichia coli K-12 requires recombination functions. J Bacteriol. 2001;183:1796-800 pubmed..We show that the miaA mutator phenotype is dependent on recombination functions similar to, but not exactly the same as, those required for translation stress-induced mutagenesis. ..
- Laverde Gomez J, Bhatty M, Christie P. PrgK, a multidomain peptidoglycan hydrolase, is essential for conjugative transfer of the pheromone-responsive plasmid pCF10. J Bacteriol. 2014;196:527-39 pubmed publisher..PrgK is indispensable for plasmid transfer in liquid matings, suggestive of a role in formation or stabilization of mating junctions. ..
- Shi X, Waasdorp B, Bennett G. Modulation of acid-induced amino acid decarboxylase gene expression by hns in Escherichia coli. J Bacteriol. 1993;175:1182-6 pubmed..These results suggest a role for the DNA-binding protein H-NS in affecting the activation of these acid-induced genes. ..
- Shelburne S, Olsen R, Makthal N, Brown N, Sahasrabhojane P, Watkins E, et al. An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes. Mol Microbiol. 2011;82:1481-95 pubmed publisher..Taken together, these data delineate a previously unknown small peptide-mediated regulatory system that controls GAS virulence factor production. ..
- Walker M, DeMoss J. Phosphorylation and dephosphorylation catalyzed in vitro by purified components of the nitrate sensing system, NarX and NarL. J Biol Chem. 1993;268:8391-3 pubmed
- Lin H, Bennett G, San K. Genetic reconstruction of the aerobic central metabolism in Escherichia coli for the absolute aerobic production of succinate. Biotechnol Bioeng. 2005;89:148-56 pubmed..Nevertheless, this aerobic succinate production system provides the first platform for enhancing succinate production aerobically in E. coli based on the creation of a new aerobic central metabolic network. ..
- Jiang Z, DuPont H, La Rocco M, Garey K. In vitro susceptibility of Clostridium difficile to rifaximin and rifampin in 359 consecutive isolates at a university hospital in Houston, Texas. J Clin Pathol. 2010;63:355-8 pubmed publisher..The study demonstrates that rifaximin has high-level activity against C difficile in vitro. Determination of resistance to rifampin by E strip did not predict rifaximin resistance. ..
- Kudo T, Lu H, Wu J, Graham D, Casola A, Yamaoka Y. Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori. Infect Immun. 2005;73:7602-12 pubmed..The mucosal inflammatory response to H. pylori infection involves different signaling pathways for activation of the RANTES promoter, with both OipA and the cag PAI being required for full activation of the RANTES promoter. ..
- Newberry K, Fuangthong M, Panmanee W, Mongkolsuk S, Brennan R. Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR. Mol Cell. 2007;28:652-64 pubmed..These changes result in the 28 degrees rigid body rotations of each winged helix-turn-helix motif and DNA dissociation. Similar effector-induced rigid body rotations are expected for most MarR family members. ..
- Britton R, Powell B, DasGupta S, Sun Q, Margolin W, Lupski J, et al. Cell cycle arrest in Era GTPase mutants: a potential growth rate-regulated checkpoint in Escherichia coli. Mol Microbiol. 1998;27:739-50 pubmed..Possible functions for Era in cell cycle progression and the initiation of cell division are discussed. ..
- Mohamed J, Teng F, Nallapareddy S, Murray B. Pleiotrophic effects of 2 Enterococcus faecalis sagA-like genes, salA and salB, which encode proteins that are antigenic during human infection, on biofilm formation and binding to collagen type i and fibronectin. J Infect Dis. 2006;193:231-40 pubmed publisher
- Guo B, Brown E, Dorward D, Rosenberg L, Hook M. Decorin-binding adhesins from Borrelia burgdorferi. Mol Microbiol. 1998;30:711-23 pubmed..Taken together, these data suggest that Dbps are adhesins of the MSCRAMM (microbial surface component-recognizing adhesive matrix molecule) family, which mediate B. burgdorferi attachment to the extracellular matrix of the host. ..
- Seidle H, Couch R, Parry R. Characterization of a nonspecific phosphopantetheinyl transferase from Pseudomonas syringae pv. syringae FF5. Arch Biochem Biophys. 2006;446:167-74 pubmed publisher..In contrast, the most efficient substrates for PcpS are CPs from primary metabolism. These results indicate phosphopantetheinyl transferases from different Pseudomonas sp. may vary significantly in their enzymatic properties...
- Balzer G, Thakker C, Bennett G, San K. Metabolic engineering of Escherichia coli to minimize byproduct formate and improving succinate productivity through increasing NADH availability by heterologous expression of NAD(+)-dependent formate dehydrogenase. Metab Eng. 2013;20:1-8 pubmed publisher..Reduced levels of byproduct formate in succinate fermentation broth would provide an opportunity for reducing the cost associated with downstream processing, purification, and waste disposal. ..
- Prithivirajsingh S, Mishra S, Mahadevan A. Detection and analysis of chromosomal arsenic resistance in Pseudomonas fluorescens strain MSP3. Biochem Biophys Res Commun. 2001;280:1393-401 pubmed..Southern hybridization and mating experiments confirmed the functioning of the ars genes in the operon, thereby conferring increased resistance to sodium arsenate and sodium arsenite. ..
- Davidson A. Structural biology. Not just another ABC transporter. Science. 2002;296:1038-40 pubmed
- Tan X, Rose K, Margolin W, Chen Y. DNA enzyme generated by a novel single-stranded DNA expression vector inhibits expression of the essential bacterial cell division gene ftsZ. Biochemistry. 2004;43:1111-7 pubmed
- Sack J, Trakhanov S, Tsigannik I, Quiocho F. Structure of the L-leucine-binding protein refined at 2.4 A resolution and comparison with the Leu/Ile/Val-binding protein structure. J Mol Biol. 1989;206:193-207 pubmed..These substitutions, by themselves, fail to clearly explain the differences in the specificities for branched aliphatic amino acids. ..
- Wang D, Botkin D, Norris S. Characterization of the vls antigenic variation loci of the Lyme disease spirochaetes Borrelia garinii Ip90 and Borrelia afzelii ACAI. Mol Microbiol. 2003;47:1407-17 pubmed..This study indicates that the vls loci present in B. garinii Ip90 and B. afzelii ACAI have characteristics similar to those found in B. burgdorferi B31. ..
- Kwon D, Dore M, Kim J, Kato M, Lee M, Wu J, et al. High-level beta-lactam resistance associated with acquired multidrug resistance in Helicobacter pylori. Antimicrob Agents Chemother. 2003;47:2169-78 pubmed..pylori is mediated by combination strategies including alterations of PBP 1A and decreased membrane permeability...
- Doyle C, Davis B, Cook R, Rich R, Rodgers J. Hyperconservation of the N-formyl peptide binding site of M3: evidence that M3 is an old eutherian molecule with conserved recognition of a pathogen-associated molecular pattern. J Immunol. 2003;171:836-44 pubmed..Such MHC PRR molecules could have been preadaptations for the evolution of acquired immunity during the early vertebrate radiation. ..