Experts and Doctors on amino acid sequence in Houston, Texas, United States


Locale: Houston, Texas, United States
Topic: amino acid sequence

Top Publications

  1. Lo J, Smith L, Chan L. Lipoprotein lipase: role of intramolecular disulfide bonds in enzyme catalysis. Biochem Biophys Res Commun. 1995;206:266-71 pubmed
    ..The conservation of catalytic function despite the disruption of the only disulfide bridge in the C-terminal domain of LPL indicates that the two domains can function independently of each other in enzyme catalysis. ..
  2. Yang C, Gu Z, Blanco Vaca F, Gaskell S, Yang M, Massey J, et al. Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. Biochemistry. 1994;33:12451-5 pubmed
    ..We conclude that apoD binds to lipoprotein surfaces through structures other than alpha-helices, such as disulfide links...
  3. Wilkemeyer M, Crane A, Ledley F. Primary structure and activity of mouse methylmalonyl-CoA mutase. Biochem J. 1990;271:449-55 pubmed
    ..These results establish that mouse MCM is homologous to human MCM in structure and function and provides a basis for using the mouse as a model for studying this enzyme and its deficiency state. ..
  4. Zhou L, Rosevear P. Mutation of the carboxy terminal zinc finger of E. coli isoleucyl-tRNA synthetase alters zinc binding and aminoacylation activity. Biochem Biophys Res Commun. 1995;216:648-54 pubmed
    ..These results suggest that both the C-terminal enzyme-bound zinc and the C-terminal peptide play important roles in aminoacylation of tRNA(Ile). ..
  5. Warren A, Patel K, McConkey D, Palacios R. CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells. Blood. 1996;87:3676-87 pubmed
    ..We suggest that CD98 is a cell membrane receptor involved in the control of cell survival/death of hematopoietic cells. ..
  6. Roa B, Warner L, Garcia C, Russo D, Lovelace R, Chance P, et al. Myelin protein zero (MPZ) gene mutations in nonduplication type 1 Charcot-Marie-Tooth disease. Hum Mutat. 1996;7:36-45 pubmed
    ..These observations provide further confirmation of the role of MPZ in CMT1B and suggest that MPZ coding region mutations may account for a limited percentage of disease-causing mutations in nonduplication CMT1 patients. ..
  7. Zhuchenko O, Bailey J, Bonnen P, Ashizawa T, Stockton D, Amos C, et al. Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel. Nat Genet. 1997;15:62-9 pubmed
    ..We conclude that a small polyglutamine expansion in the human alpha 1A calcium channel is most likely the cause of a newly classified autosomal dominant spinocerebellar ataxia, SCA6. ..
  8. Segura M, Lodeiro S, Meyer M, Patel A, Matsuda S. Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis. Org Lett. 2002;4:4459-62 pubmed
    ..The His477Gln mutant produces 73% parkeol, 22% lanosterol, and 5% Delta(7)-lanosterol. These are the most accurate lanosterol synthase and parkeol synthase that have been generated by mutagenesis. ..
  9. Bhat K, Itahana K, Jin A, Zhang Y. Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. EMBO J. 2004;23:2402-12 pubmed
    ..Growth inhibition, presumably through suppression of rRNA production in the nucleolus, facilitates translocation of L11 to the nucleoplasm, thus activating p53 through inhibiting HDM2. ..

More Information

Publications465 found, 100 shown here

  1. Vatta M, Ackerman M, Ye B, Makielski J, Ughanze E, Taylor E, et al. Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome. Circulation. 2006;114:2104-12 pubmed
    ..The present study reports the first CAV3 mutations in subjects with LQTS, and we provide functional data demonstrating a gain-of-function increase in late sodium current. ..
  2. Mu J, Wang Y, Luo H, Leng M, Zhang J, Yang T, et al. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem. 2007;282:17330-4 pubmed
  3. Chung S, Weiss R, Frese K, Prasad B, Javier R. Functionally distinct monomers and trimers produced by a viral oncoprotein. Oncogene. 2008;27:1412-20 pubmed
    ..This work exposes a novel strategy wherein the oligomerization state of a protein not only determines the capacity to bind separate related targets but also couples the interactions to different functional consequences. ..
  4. Shchelochkov O, Li F, Geraghty M, Gallagher R, Van Hove J, Lichter Konecki U, et al. High-frequency detection of deletions and variable rearrangements at the ornithine transcarbamylase (OTC) locus by oligonucleotide array CGH. Mol Genet Metab. 2009;96:97-105 pubmed publisher
    ..Thus, the test should be considered in OTC sequencing-negative patients with classic symptoms of the disease. ..
  5. Chen H, Xia Y, Fang D, Hawke D, Lu Z. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol. 2009;29:3657-64 pubmed publisher
    ..The downregulation of Hsp90 beta mediated by caspase-8-dependent caspase-10 activation promoted UVB-induced cell apoptosis. ..
  6. Xia Y, Yamaoka Y, Zhu Q, Matha I, Gao X. A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori. PLoS ONE. 2009;4:e7736 pubmed publisher
    ..Our results shed light on the relationships between the types of CagAs, the country of origin of each sequence type, and the frequency of gastric disease. ..
  7. Munoz W, Kloc M, Cho K, Lee M, Hofmann I, Sater A, et al. Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues. PLoS ONE. 2012;7:e34342 pubmed publisher
    ..The use of two distinct morpholinos, as well as rescue approaches, indicated the specificity of these effects. Our results point to the requirement of Pkp3 in amphibian embryogenesis, with functional roles in a number of tissue types...
  8. Denzel M, Storm N, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, et al. Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell. 2014;156:1167-1178 pubmed publisher
    ..Evidently, hexosamine pathway activation or N-acetylglucosamine supplementation induces distinct protein quality control mechanisms, which may allow therapeutic intervention against age-related and proteotoxic diseases...
  9. Vitrac H, Dowhan W, Bogdanov M. Effects of mixed proximal and distal topogenic signals on the topological sensitivity of a membrane protein to the lipid environment. Biochim Biophys Acta Biomembr. 2017;1859:1291-1300 pubmed publisher
  10. Mars W, Van Tuinen P, Drabkin H, White J, Saunders G. A myeloid-related sequence that localizes to human chromosome 8q21.1-22. Blood. 1988;71:1713-9 pubmed
  11. Zhao G, Zhou X, Eberspaecher H, Solursh M, de Crombrugghe B. Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes. Proc Natl Acad Sci U S A. 1993;90:8633-7 pubmed
    ..No hybridization was observed in brain, spinal cord, heart, spleen, gastrointestinal tract, liver, and muscle. We speculate that Cart-1 has a role in chondrocyte differentiation. ..
  12. Guo D, Bowden M, Pershad R, Kaplan H. The Myxococcus xanthus rfbABC operon encodes an ATP-binding cassette transporter homolog required for O-antigen biosynthesis and multicellular development. J Bacteriol. 1996;178:1631-9 pubmed
    ..These data indicate that the sasA locus is required for the biosynthesis of O-antigen and, when mutated, results in A-signal-independent expression of 4521. ..
  13. Stafford L, Xia C, Ma W, Cai Y, Liu M. Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002;62:5399-404 pubmed
    ..Furthermore, activation of the KiSS1 receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. ..
  14. Wang H, Yang L, Jamaluddin M, Boyd D. The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells. J Biol Chem. 2004;279:22674-83 pubmed
    ..In conclusion, we have identified KLF4 as a novel regulator of u-PAR expression that drives the synthesis of u-PAR in the luminal surface epithelial cells of the colon. ..
  15. Fu Y, Pizzuti A, Fenwick R, King J, Rajnarayan S, Dunne P, et al. An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science. 1992;255:1256-8 pubmed
    ..The triplet repeat sequence is within a gene (to be referred to as myotonin-protein kinase), which has a sequence similar to protein kinases. ..
  16. Schwoebel E, Prasad S, Timmons T, Cook R, Kimura H, Niu E, et al. Isolation and characterization of a full-length cDNA encoding the 55-kDa rabbit zona pellucida protein. J Biol Chem. 1991;266:7214-9 pubmed
  17. Aitken J, van Heusden G, Temkin M, Dowhan W. The gene encoding the phosphatidylinositol transfer protein is essential for cell growth. J Biol Chem. 1990;265:4711-7 pubmed
    ..Nonviable spores could be rescued by transformation of the above diploid prior to sporulation, with a plasmid-borne copy of the wild type gene. ..
  18. Conneely O, Kettelberger D, Tsai M, Schrader W, O Malley B. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event. J Biol Chem. 1989;264:14062-4 pubmed
    ..Both proteins are transcriptionally active in terms of their ability to activate a progesterone-responsive target gene. These results suggest a functional significance for evolutionary conservation of two forms of this steroid receptor. ..
  19. Martha A, Ferrell R, Mintz Hittner H, Lyons L, Saunders G. Paired box mutations in familial and sporadic aniridia predicts truncated aniridia proteins. Am J Hum Genet. 1994;54:801-11 pubmed
    ..All five mutations predict truncated PAX6 proteins. Our study indicates that early premature translational termination mutations in the PAX6 gene result in haploinsufficiency and generate the aniridia phenotype...
  20. Ishimura Oka K, Nakamuta M, Chu M, Sullivan M, Chan L, Oka K. Partial structure of the mouse glucokinase gene. Genomics. 1995;29:751-4 pubmed
    ..Several transcription factor-binding consensus sequences are identified in the 5' flanking region of the mouse GK gene. ..
  21. Loflin P, Laud P, Watkins D, Lawlor D. Identification of new TAP2 alleles in gorilla: evolution of the locus within hominoids. Immunogenetics. 1996;44:161-9 pubmed
    ..The absence of ancestral polymorphisms suggests that gorilla and human TAP2 genes have not evolved in a trans-species fashion but rather have diversified since the divergence of the lineages...
  22. Bérubé N, Swanson X, Bertram M, Kittle J, Didenko V, Baskin D, et al. Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function. Brain Res Mol Brain Res. 1999;63:233-40 pubmed
    ..The mouse CRF homolog is highly similar to the human gene at both the nucleotide and protein level, suggesting an important conserved role for this protein. ..
  23. Arin M, Longley M, Kuster W, Huber M, Hohl D, Rothnagel J, et al. An asparagine to threonine substitution in the 1A domain of keratin 1: a novel mutation that causes epidermolytic hyperkeratosis. Exp Dermatol. 1999;8:124-7 pubmed
    ..This is the region involved in molecular overlaps between neighboring keratin heterodimers. These findings suggest that even conservative amino acid substitutions in overlap regions can cause tonofilament clumping. ..
  24. Burgess D, Davis C, Gefrides L, Noebels J. Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. 1999;9:1204-13 pubmed
    ..These results demonstrate the value of genome evolution models for the identification of distantly related members of gene families. ..
  25. Srivenugopal K, Mullapudi S, Shou J, Hazra T, Ali Osman F. Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells. Cancer Res. 2000;60:282-7 pubmed
    ..These data provide the first and conclusive evidence of AGT phosphorylation and suggest that reversible phosphorylation may control the activity of this therapeutically important DNA repair protein in human normal and cancer cells. ..
  26. Koch P, de Viragh P, Scharer E, Bundman D, Longley M, Bickenbach J, et al. Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol. 2000;151:389-400 pubmed
  27. Xia C, Ma W, Stafford L, Marcus S, Xiong W, Liu M. Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1. Proc Natl Acad Sci U S A. 2001;98:6174-9 pubmed
    ..Cotransfection of hPIP1 in mammalian cells inhibits PAK-mediated c-Jun N-terminal kinase and nuclear factor kappa B signaling pathways. Our results demonstrate that hPIP1 is a negative regulator of PAK and PAK signaling pathways. ..
  28. Sato K, Dang N. CD26: a novel treatment target for T-cell lymphoid malignancies? (Review). Int J Oncol. 2003;22:481-97 pubmed
    ..Finally, we will present recent work from our laboratory that indicates a potential role for CD26 as a molecular target for novel treatment modalities for T-cell lymphoid malignancies. ..
  29. Price M, Davis C, Deng F, Burgess D. The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptor trafficking regulator "stargazin" is related to the claudin family of proteins by Its ability to mediate cell-cell adhesion. J Biol Chem. 2005;280:19711-20 pubmed
    ..We speculate these complexes may have co-opted the established presence of stargazin at sites of close cell-cell contact to facilitate their own evolving intercellular signaling functions. ..
  30. Graham B, Craigen W. Mitochondrial voltage-dependent anion channel gene family in Drosophila melanogaster: complex patterns of evolution, genomic organization, and developmental expression. Mol Genet Metab. 2005;85:308-17 pubmed
  31. Dejournett R, Kobayashi R, Pan S, Wu C, Etkin L, Clark R, et al. Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteins. Biochem J. 2007;401:521-31 pubmed
    ..These findings establish that Xp95/Alix is phosphorylated within the PRD during M-phase induction, and indicate that the phosphorylation may both positively and negatively modulate their interaction with partner proteins. ..
  32. Blankschien M, Potrykus K, Grace E, Choudhary A, Vinella D, Cashel M, et al. TraR, a homolog of a RNAP secondary channel interactor, modulates transcription. PLoS Genet. 2009;5:e1000345 pubmed publisher
    ..Implications for DksA/ppGpp mechanism and roles of TraR in horizontal gene transfer and virulence are discussed. ..
  33. Mull B, Cox J, Bui T, Keyomarsi K. Post-translational modification and stability of low molecular weight cyclin E. Oncogene. 2009;28:3167-76 pubmed publisher
    ..The stability of low molecular weight cyclin E may have implications for both tumorigenesis and treatment of tumors expressing them. ..
  34. Liu W, da Silva G, Wu G, Palmer G, Tsai A, Kulmacz R. Functional and structural roles of residues in the third extramembrane segment of adrenal cytochrome b561. Biochemistry. 2011;50:3149-60 pubmed publisher
    ..These results also support our topological model of the adrenal cytochrome, which positions b(H) near the cytoplasmic side of the membrane. ..
  35. Wang J, Morton M, Elliott C, Karoonuthaisiri N, Segatori L, Biswal S. Rapid detection of pathogenic bacteria and screening of phage-derived peptides using microcantilevers. Anal Chem. 2014;86:1671-8 pubmed publisher
  36. Sharff A, Rodseth L, Spurlino J, Quiocho F. Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis. Biochemistry. 1992;31:10657-63 pubmed
  37. Roa B, Garcia C, Pentao L, Killian J, Trask B, Suter U, et al. Evidence for a recessive PMP22 point mutation in Charcot-Marie-Tooth disease type 1A. Nat Genet. 1993;5:189-94 pubmed
  38. Pati D, Keller C, Groudine M, Plon S. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Mol Cell Biol. 1997;17:3037-46 pubmed
    ..Analysis of CHES1 activity is most consistent with activation of an alternative MEC1-independent checkpoint pathway in budding yeast. ..
  39. Kamitani T, Kito K, Nguyen H, Yeh E. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J Biol Chem. 1997;272:28557-62 pubmed
    ..Taken together, NEDD8 provides another substrate for covalent protein modification and may play a unique role during development. ..
  40. Chen M, Lin S, Chung L, Sikes R. Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. J Biol Chem. 1998;273:17618-25 pubmed
  41. Hoke D, Regisford E, Julian J, Amin A, Bègue Kirn C, Carson D. Murine HIP/L29 is a heparin-binding protein with a restricted pattern of expression in adult tissues. J Biol Chem. 1998;273:25148-57 pubmed
    ..Collectively, these data indicate that murine HIP/L29, like its human ortholog, is a Hp-binding protein expressed in a restricted manner in adult tissues. ..
  42. Rana B, Hewett Emmett D, Jin L, Chang B, Sambuughin N, Lin M, et al. High polymorphism at the human melanocortin 1 receptor locus. Genetics. 1999;151:1547-57 pubmed
    ..In addition, the nucleotide diversity at the MC1R locus is shown to be several times higher than the average nucleotide diversity in human populations, possibly due to diversifying selection. ..
  43. Chen A, Zhou G, Juan T, Colicos S, Cannon J, Cabriera Hansen M, et al. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. J Biol Chem. 2002;277:36592-601 pubmed
    ..Taken together, these studies identify a positive regulator for the JNK pathway and suggest a novel role for DSP in mitogen-activated protein kinase regulation. ..
  44. Voo K, Fu T, Wang H, Tellam J, Heslop H, Brenner M, et al. Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes. J Exp Med. 2004;199:459-70 pubmed
  45. Shigaki T, Rees I, Nakhleh L, Hirschi K. Identification of three distinct phylogenetic groups of CAX cation/proton antiporters. J Mol Evol. 2006;63:815-25 pubmed
    ..For the first time, these results clearly define the CAX exchanger family and its subtypes in phylogenetic terms. The surprising diversity of CAXs demonstrates their potential range of biochemical properties and physiologic relevance. ..
  46. Bover L, Cardo Vila M, Kuniyasu A, Sun J, Rangel R, Takeya M, et al. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol. 2007;178:8183-94 pubmed
    ..Together, these data are consistent with the hypothesis that CD163 either acts as a TWEAK scavenger in pathological conditions or serves as an alternate receptor for TWEAK in cells lacking Fn14/TweakR. ..
  47. Sasaki J, Nara T, Spudich E, Spudich J. Constitutive activity in chimeras and deletions localize sensory rhodopsin II/HtrII signal relay to the membrane-inserted domain. Mol Microbiol. 2007;66:1321-30 pubmed
  48. Gregorio J, Meller S, Conrad C, Di Nardo A, Homey B, Lauerma A, et al. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med. 2010;207:2921-30 pubmed publisher
    ..These data uncover a new role of pDCs in sensing tissue damage and promoting wound repair at skin surfaces. ..
  49. Ganesh V, Barbu E, Deivanayagam C, Le B, Anderson A, Matsuka Y, et al. Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactions. J Biol Chem. 2011;286:25963-72 pubmed publisher
    ..A common motif GSSGXG found in both ligands is part of the ClfB-binding site. This motif is found in many human proteins thus raising the possibility that ClfB recognizes additional ligands. ..
  50. Honsa E, Owens C, Goulding C, Maresso A. The near-iron transporter (NEAT) domains of the anthrax hemophore IsdX2 require a critical glutamine to extract heme from methemoglobin. J Biol Chem. 2013;288:8479-90 pubmed publisher
  51. Lee J, DeHoff B, Donohue T, Gumport R, Kaplan S. Transcriptional analysis of puf operon expression in Rhodobacter sphaeroides 2.4.1 and an intercistronic transcription terminator mutant. J Biol Chem. 1989;264:19354-65 pubmed
    ..9-fold) of the 120-nucleotide RNA, suggesting that its synthesis is under the control of the puf operon despite the fact that its sequence appears to overlap the next downstream operon. ..
  52. Edwards R, Herrera Sosa H, Otto J, Bryan J. Cloning and expression of a murine fascin homolog from mouse brain. J Biol Chem. 1995;270:10764-70 pubmed
    ..Electron cryomicroscopy images show that the reconstituted bundles are highly ordered. However, their fine structure differs from that of echinoid fascin-actin bundles. This structural difference can be attributed to fascin. ..
  53. Lefebvre V, Huang W, Harley V, Goodfellow P, de Crombrugghe B. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol. 1997;17:2336-46 pubmed
    ..We speculate that in campomelic dysplasia a decrease in SOX9 activity would inhibit production of collagen II, and eventually other cartilage matrix proteins, leading to major skeletal anomalies. ..
  54. Charng M, Zhang D, Kinnunen P, Schneider M. A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor. J Biol Chem. 1998;273:9365-8 pubmed
    ..Thus, TRAP-1 can distinguish activated forms of the receptor from wild-type receptor in the absence of TGFbeta and may potentially have a functional role in TGFbeta signaling. ..
  55. Qin X, Singh K, Weinstock G, Murray B. Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence. Infect Immun. 2000;68:2579-86 pubmed
    ..These results suggest that sprE and agr-like genes contribute to the virulence of E. faecalis OG1RF in this model...
  56. Abidari J, Gonzales E, Inoue K, Lupski J, Karsenty G, Katsanis N. Identification of novel genes expressed during metanephric induction through single-cell library screening. Kidney Int. 2000;57:2221-8 pubmed
    ..0 and E11.5 metanephric mesenchyme single-cell cDNA libraries, we have identified novel genes that are candidates for involvement in nephrogenesis through their up-regulation during the inductive process. ..
  57. Ladd A, Charlet N, Cooper T. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol Cell Biol. 2001;21:1285-96 pubmed
    ..We propose that ETR-3 is a major regulator of cTNT alternative splicing and that the CELF family plays an important regulatory role in cell-specific alternative splicing during normal development and disease. ..
  58. El Hodiri H, Bhatia Dey N, Kenyon K, Ault K, Dirksen M, Jamrich M. Fox (forkhead) genes are involved in the dorso-ventral patterning of the Xenopus mesoderm. Int J Dev Biol. 2001;45:265-71 pubmed
    ..Expression pattern and functional experiments indicate that these three forkhead genes are involved in the dorso-ventral patterning of the mesoderm. ..
  59. Guo X, Stafford L, Bryan B, Xia C, Ma W, Wu X, et al. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. J Biol Chem. 2003;278:13207-15 pubmed
    ..Together, our data suggest that GEFT is a Rac/Cdc42-specific GEF protein that regulates cell morphology, cell proliferation, and transformation. ..
  60. Tan M, Lan K, Yao J, Lu C, Sun M, Neal C, et al. Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptide. Cancer Res. 2006;66:3764-72 pubmed
    ..This novel peptide delivery system provided a sound basis for the future development of safe and effective new-generation therapeutics to cancer-specific molecular targets. ..
  61. Malovannaya A, Lanz R, Jung S, Bulynko Y, Le N, Chan D, et al. Analysis of the human endogenous coregulator complexome. Cell. 2011;145:787-99 pubmed publisher
    ..This resource will effectively fill a void in linking correlative genomic studies with an understanding of transcriptional regulatory protein functions within the proteome for formulation and testing of future hypotheses. ..
  62. Huai L, Chiocca S, Gilbreth M, Ainsworth J, Bishop L, Murphy E. Moloney murine sarcoma virus MuSVts110 DNA: cloning, nucleotide sequence, and gene expression. J Virol. 1992;66:5329-37 pubmed
  63. Metsaranta M, Toman D, de Crombrugghe B, Vuorio E. Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. Biochim Biophys Acta. 1991;1089:241-3 pubmed
    ..The clone for mouse alpha 1(IX) collagen covers coding sequences but is sufficiently divergent from other collagen transcripts to allow specific detection of the corresponding mRNA. ..
  64. Lee C, Craigen W, Muzny D, Harlow E, Caskey C. Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases. Proc Natl Acad Sci U S A. 1990;87:3508-12 pubmed
  65. Chen H, Sun Y, Stark T, Beattie W, Moses R. Nucleotide sequence and deletion analysis of the polB gene of Escherichia coli. DNA Cell Biol. 1990;9:631-5 pubmed
    ..We have also demonstrated that the polB sequence is lacking in some strains. We conclude that DNA polymerase II is not a required protein in the cell. Sequence comparisons show that DNA polymerase II is an alpha-like DNA polymerase. ..
  66. Denner L, Schrader W, O Malley B, Weigel N. Hormonal regulation and identification of chicken progesterone receptor phosphorylation sites. J Biol Chem. 1990;265:16548-55 pubmed
    ..Both the in vivo and in vitro alterations were reversed by alkaline phosphatase. Finally, we showed that cAMP-dependent protein kinase phosphorylated Ser-528. ..
  67. Yang C, Gu Z, Yang H, Rohde M, Gotto A, Pownall H. Structure of bovine milk lipoprotein lipase. J Biol Chem. 1989;264:16822-7 pubmed
    ..The chymotrypsin nick of bLPL was determined to be between residues 390 and 391. A model of the enzyme is proposed on the basis of our data and available chemical data. ..
  68. Birnbaumer M, Hinrichs Rosello M, Cook R, Schrader W, O Malley B. Chemical and antigenic properties of pure 108,000 molecular weight chick progesterone receptor. Mol Endocrinol. 1987;1:249-59 pubmed
    ..It was absent in receptor-negative tissues such as liver and lung. The receptor was cleaved with cyanogen bromide and trypsin to obtain fragments that were partially sequenced. ..
  69. Wimmer E, Jackle H, Pfeifle C, Cohen S. A Drosophila homologue of human Sp1 is a head-specific segmentation gene. Nature. 1993;366:690-4 pubmed
    ..A ubiquitous transcription factor from humans can therefore replace an essential component of the genetic circuitry required to specify the development of a particular head segment in the fly. ..
  70. Chong S, Kristjansson K, Zoghbi H, Hughes M. Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. Genomics. 1993;18:355-9 pubmed
    ..Polypeptide hydropathy analysis predicts several membrane-spanning domains. This cDNA maps the location of the gene encoding NPT1 to human chromosome 6q21.3-p23. ..
  71. Lau A, Nishimori K, Matzuk M. Structural analysis of the mouse activin beta C gene. Biochim Biophys Acta. 1996;1307:145-8 pubmed
    ..1 kb. The liver-specific expression of activin beta C suggests an important role of dimeric activin beta C in normal liver function. These studies allow us to address the function of activin beta C in mammalian development. ..
  72. Wang W, Shakes D. Molecular evolution of the 14-3-3 protein family. J Mol Evol. 1996;43:384-98 pubmed
    ..A possible ancestral 14-3-3 sequence is proposed. ..
  73. Darnay B, Haridas V, Ni J, Moore P, Aggarwal B. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 1998;273:20551-5 pubmed
  74. Dineley K, Patrick J. Amino acid determinants of alpha 7 nicotinic acetylcholine receptor surface expression. J Biol Chem. 2000;275:13974-85 pubmed
    ..How these surface expression determinants in the alpha7 nicotinic acetylcholine receptor might influence synaptic efficacy is discussed. ..
  75. Britton R, Chen S, Wallis D, Koeuth T, Powell B, Shaffer L, et al. Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era. Genomics. 2000;67:78-82 pubmed
    ..ERAL1 may be an attractive candidate for a tumor suppressor gene since ERAL1 is located in a chromosomal region where loss of heterozygosity is often associated with various types of cancer. ..
  76. Suga Y, Jarnik M, Attar P, Longley M, Bundman D, Steven A, et al. Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma. J Cell Biol. 2000;151:401-12 pubmed
    ..Thus, deposition of the mutant protein in the nucleus appears to interfere with late stages of epidermal differentiation, resulting in a VS-like phenotype. ..
  77. Knuefermann P, Chen P, Misra A, Shi S, Abdellatif M, Sivasubramanian N. Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. J Biol Chem. 2002;277:23888-97 pubmed
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